Amphiphilic poly (amino acid) linear block copolymers and nanoparticles thereof for drug delivery applications
By developing a linear copolymer containing polysarcosine and poly(amino acid) blocks, the side effects and low API water solubility in drug delivery applications in the prior art were solved, and a significant improvement in API water solubility and economic synthesis of copolymers were achieved.
CN119677795APending Publication Date: 2025-03-21NANOCERA BIOSCIENCES INC
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Patent Information
- Application Number
- CN202380050995.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Priority Date
- 2022-05-23
- Filing Date
- 2023-05-23
- Publication Date
- 2025-03-21
AI Technical Summary
Technical Problem
Existing polymer excipients have side effects in drug delivery applications and are difficult to effectively improve the water solubility of hydrophobic APIs.
Method used
A linear copolymer is developed, a polysarcosine block pSar of 15 to 99 sarcosine constituent units and a poly(amino acid) block pAA of 8 to 120 amino acid constituent units, through which nanoparticles are formed to improve the water solubility of the API.
Benefits of technology
The formation of nanoparticles by self-assembly is significantly improved, and the water solubility of the hydrophobic API is preferably greater than 100 times, and the copolymer is easy to synthesize, has a low cost, and is suitable for industrial scale expansion.
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Abstract
The present invention relates to the field of polymer chemistry, and more particularly to poly (amino acid) copolymers and their use in drug delivery applications. In particular, the present invention relates to a linear copolymer comprising a poly sarcosine block pSar comprising 15 to 99 sarcosine constituent units and a poly (amino acid) block pAA comprising 8 to 120 amino acid constituent units.
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