Oil-control acne-removal composition and application thereof

Abstract

The invention discloses an oil-controlling and acne-removing composition and an application thereof. The oil-controlling and acne-removing composition comprises the following components in parts by mass; 0.5-1.5 parts of an acne removing agent, 3-7 parts of an oil control agent, 0.5-1.5 parts of a conditioner and 15-25 parts of a humectant; the acne removing agent is prepared from melaleuca alternifolia leaf oil and face-brightening and acne-removing plant extract according to the mass ratio of (0.1 to 0.5) to (0.5 to 1.5); the oil control agent is prepared from nicotinamide, PCA zinc and an oil control agent according to the mass ratio of (2 to 4) to (0.5 to 1) to (0.5 to 1.5). Various raw materials such as the melaleuca alternifolia leaf oil, the face-brightening and acne-cleaning plant extract, the nicotinamide, the PCA zinc and the oil control formula are compounded, skin oil can be effectively reduced, symptoms such as acnes and comedos can be relieved, fragile skin can be effectively improved, meanwhile, several good amino acid surfactants and conditioners are matched, good foamability can be kept, and the skin care effect is good. The lotion has excellent stability at different high and low temperatures, and tests prove that the lotion prepared by the invention is mild and non-irritant, and has remarkable oil control and acne removal effects.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to an oil-controlling and acne-removing composition and application thereof. Background Art

[0002] Acne, also known as blackheads or pimples, is a common inflammatory skin disease. Normally, in healthy skin, sebum produced by sebaceous glands is discharged to the surface of the skin through the pores. When skin cells die and fall off, keratinocytes rise to the surface of the skin and continue to work. However, when a person has acne, hair, sebum and keratinocytes stick together in the pores, which causes keratinocytes to no longer fall off and prevents sebum from reaching the surface of the skin. The mixture of oil and cells allows bacteria that normally live on the skin to grow in the clogged follicles and cause inflammation, swelling, redness, heat and even pain. This is mainly due to the proliferation of Propionibacterium acnes, which triggers adverse reactions. When the clogged follicles rupture, bacteria, skin cells and sebum will overflow into the nearby skin, leaving scars. The scars are red at first, become dark after oxidation, and finally leave acne marks.

[0003] At present, there are many ways to treat acne, such as topical medications (adapalene, bansai), chemical peels (fruit acid peels), photorejuvenation, fractional lasers, Chinese medicine conditioning, etc. These methods often take a lot of time, energy and money, and consumers are more willing to choose some effective acne removal products. However, on the market, the ingredients for acne removal are mainly salicylic acid, pyrrolidone, benzoyl peroxide and other ingredients. Although these ingredients have good acne removal effects, they are highly irritating to the skin. Long-term use may cause side effects such as dry skin, allergies, and redness, and may even aggravate acne symptoms and cause discomfort to patients. In this case, consumers are increasingly inclined to choose those mild and effective oil-control acne removal products. These products can not only regulate sebum secretion and reduce pore blockage, but also have anti-inflammatory, antibacterial and skin barrier repair effects. In recent years, natural plant ingredients such as tea tree oil and aloe vera have been widely used in skin care products due to their natural antibacterial and anti-inflammatory properties, showing good results. In addition, some emerging bioactive ingredients, such as probiotics and hyaluronic acid, have gradually become important ingredients in oil-control and acne-removing products. They can gently regulate the skin's microecology, enhance the skin's barrier function, and reduce the recurrence of acne.

[0004] However, although many oil-control and acne-removing products have appeared on the market, most of them still face the problem of balancing effectiveness and safety. Most existing oil-control and acne-removing compositions have shown some effects in oil control and anti-inflammatory, but still have certain deficiencies in reducing skin irritation and restoring skin barrier function. Therefore, developing an acne-removing composition that can effectively control oil, inhibit bacteria, and reduce inflammation, while reducing skin irritation and having a good repairing effect is still a technical problem that needs to be solved in the current field of acne treatment. Summary of the invention

[0005] In view of the above-mentioned prior art, the object of the present invention is to provide an oil-controlling and acne-removing composition and application thereof.

[0006] To achieve the above object, the present invention adopts the following technical solution:

[0007] The first aspect of the present invention provides an oil-controlling and anti-acne composition, comprising the following components in parts by weight:

[0008] 0.5-1.5 parts of anti-acne agent, 3-7 parts of oil control agent, 0.5-1.5 parts of conditioning agent and 15-25 parts of moisturizer;

[0009] The acne-removing agent is composed of Melaleuca alternifolia leaf oil and brightening and acne-clearing plant extract in a mass ratio of (0.1-0.5): (0.5-1.5);

[0010] The oil control agent is composed of niacinamide, PCA zinc and oil control formula in a mass ratio of (2-4): (0.5-1): (0.5-1.5);

[0011] The brightening and acne-clearing plant extract was purchased from Shandong Mingren Freda Pharmaceutical Co., Ltd.

[0012] The oil control formula was purchased from Shanghai Zhina Biotechnology Co., Ltd.

[0013] Preferably, the conditioning agent is composed of polyquaternium-39, Centella asiatica extract and Portulaca oleracea extract in a mass ratio of (0.01-0.05):(0.1-0.2):(0.5-1).

[0014] Preferably, the humectant is glycerin.

[0015] The second aspect of the present invention provides use of the above-mentioned oil-controlling and anti-acne composition in the preparation of oil-controlling and anti-acne products.

[0016] Preferably, the product is any one of a cream, an emulsion, an aqueous solution, a gel, a facial mask or a lotion.

[0017] The third aspect of the present invention provides an oil-controlling and anti-acne lotion, comprising the above-mentioned oil-controlling and anti-acne composition.

[0018] Preferably, the added amount of the oil-controlling and anti-acne composition is 15-40% of the mass of the oil-controlling and anti-acne lotion.

[0019] Preferably, the oil-controlling and anti-acne lotion further comprises an auxiliary agent and water, wherein the auxiliary agent accounts for 20% to 30% of the mass of the oil-controlling and anti-acne lotion, and the remainder is water; the auxiliary agent is composed of a detergent, a thickener, an emulsifier and a preservative in a mass ratio of (16-23): (1.5-3): (1-2): (0.6-1.5).

[0020] Preferably, the cleaning agent is composed of potassium cocoyl glycinate, sodium cocoyl amphoacetate and disodium lauryl sulfosuccinate in a mass ratio of (15-20):(1-1.5):(0.4-1).

[0021] Preferably, the thickener is composed of acrylic acid (ester) copolymer and sodium chloride in a mass ratio of (0.5-1): (1-2).

[0022] Preferably, the emulsifier is glyceryl stearate SE.

[0023] Preferably, the preservative is H-833.

[0024] Preferably, the oil-controlling and anti-acne lotion is prepared by the following method:

[0025] (1) adding a detergent, a moisturizer, and an emulsifier to water, heating to 80-85° C., and stirring; after the water is completely dissolved, stopping heating, adding a thickener dispersed in advance, stirring, and cooling to obtain a mixed solution;

[0026] (2) After cooling to 40-45°C, add preservatives, acne removers, oil control agents, and conditioning agents to the mixed solution and stir to dissolve. After the material forms a paste, stop stirring and let it stand for 10-14 hours.

[0027] Beneficial effects of the present invention:

[0028] The present invention compounds a variety of raw materials such as Melaleuca alternifolia leaf oil, brightening and acne-clearing plant essence, niacinamide, PCA zinc and an oil-controlling formula, which can effectively reduce skin oiliness, relieve symptoms such as acne and blackheads, and effectively improve fragile skin. At the same time, it is matched with several good amino acid surfactants and conditioners to maintain good foaming properties and have excellent stability at different high and low temperatures. Experiments have confirmed that the lotion prepared by the present invention is mild and non-irritating, and has significant oil-control and acne-removing effects. DETAILED DESCRIPTION

[0029] It should be noted that the following detailed descriptions are illustrative and are intended to provide further explanation of the present application. Unless otherwise specified, all technical and scientific terms used herein have the same meanings as those commonly understood by those skilled in the art to which the present application belongs.

[0030] In order to enable those skilled in the art to more clearly understand the technical solution of the present application, the technical solution of the present application will be described in detail below in conjunction with specific embodiments.

[0031] The test materials used in the examples of the present invention are all conventional test materials in the art and can be purchased through commercial channels.

[0032] Among them, Melaleuca alternifolia leaf oil was purchased from Main Camp Natural Extracts Pty Ltd.

[0033] Mingyan Qingacne Plant Essence: purchased from Shandong Mingren Freda Pharmaceutical Co., Ltd., version number: 20230201-01.

[0034] Niacinamide: purchased from Shandong Kunda Biotechnology Co., Ltd.

[0035] PCA zinc: purchased from Xianting (Guangzhou) Trading Co., Ltd.

[0036] Oil control formula: purchased from Shanghai Zhina Biotechnology Co., Ltd., product number: DH071.

[0037] Polyquaternium-39: purchased from Lubrizol Advanced Materials, Inc.

[0038] Centella asiatica extract: purchased from Guangxi Changzhou Natural Pharmaceutical Co., Ltd.

[0039] Purslane extract: purchased from Shanghai Huiwen Biotechnology Co., Ltd.

[0040] Potassium cocoyl glycinate: purchased from Guangzhou Baifulun Chemical Co., Ltd.

[0041] Sodium cocoamphoacetate: purchased from Shanghai Hongdu Fine Chemical Co., Ltd.

[0042] Disodium lauryl sulfosuccinate: purchased from Zhangjiagang Great Chemical Co., Ltd.

[0043] Glycerol: purchased from Musim Mas Investment (China) Co., Ltd.

[0044] Acrylic acid (ester) copolymer: purchased from Lubrizol Advanced Materials, Inc.

[0045] Sodium chloride: purchased from Sinopharm Chemical Reagent Co., Ltd.

[0046] Glyceryl stearate SE: purchased from NIHON EMULSION CO., LTD.

[0047] H-833: purchased from Guangdong Hainuo Kewei Biopharmaceutical Co., Ltd.

[0048] Example 1: Preparation of an oil-controlling and acne-removing composition:

[0049] (1) Raw material composition (parts by weight):

[0050] 0.2 parts of Melaleuca alternifolia leaf oil, 1 part of brightening and acne-clearing plant essence, 3 parts of niacinamide, 0.5 parts of PCA zinc, 1 part of oil control formula, 0.03 parts of quaternary ammonium salt-39, 0.2 parts of Centella asiatica extract, 1 part of Portulaca oleracea extract, and 20 parts of glycerin;

[0051] The above raw materials are mixed evenly to obtain an oil-controlling and acne-removing composition.

[0052] Example 2: Preparation of oil-controlling acne-removing lotion:

[0053] (1) Raw material composition (mass percentage):

[0054] Melaleuca alternifolia leaf oil 0.2%, brightening and acne-clearing plant essence 1%, niacinamide 3%, PCA zinc 0.5%, oil control formula 1%, quaternary ammonium salt-39 0.03%, Centella asiatica extract 0.2%, Portulaca oleracea extract 1%, potassium cocoyl glycinate 16%, sodium cocoamphoacetate 1.2%, disodium lauryl sulfosuccinate 0.5%, glycerin 20%, acrylic acid (ester) copolymer 0.5%, sodium chloride 1.3%, glyceryl stearate SE 1.5%, H-833 0.8%, water to make up the balance to 100%;

[0055] Among them, Melaleuca alternifolia leaf oil and Mingyanjingqiao plant essence are used as acne-removing agents, niacinamide, PCA zinc and oil-control formula are used as oil-control agents, polyquaternium-39, Centella asiatica extract and Portulaca oleracea extract are used as conditioning agents, potassium cocoyl glycinate, sodium cocoylamphoacetate and disodium lauryl sulfosuccinate are used as cleansing agents, glycerin is used as a moisturizer, acrylic acid (ester) copolymer and sodium chloride are used as thickeners, and glyceryl stearate SE is used as an emulsifier. H-833 as a preservative;

[0056] (2) Preparation method:

[0057] Add potassium cocoyl glycinate, sodium cocoyl amphoacetate, disodium lauryl sulfosuccinate, glycerin, and glyceryl stearate SE to water, heat to 80° C., and stir; after they are completely dissolved, stop heating, add pre-dispersed acrylic acid (ester) copolymer and sodium chloride, stir, and cool to obtain a mixed solution;

[0058] After cooling to 40°C, H-833, Melaleuca alternifolia leaf oil, brightening and acne-clearing plant extract, niacinamide, PCA zinc, oil-control formula, quaternary ammonium salt-39, Centella asiatica extract, and Portulaca oleracea extract are added to the mixed solution and stirred to dissolve. After the material forms a paste, stirring is stopped and the oil-control and acne-clearing lotion is obtained after standing for 12 hours.

[0059] Example 3: Preparation of oil-controlling acne-removing lotion:

[0060] (1) Raw material composition (mass percentage):

[0061] Melaleuca alternifolia leaf oil 0.1%, brightening and acne-clearing plant extract 1.5%, niacinamide 2%, PCA zinc 1%, oil control formula 0.5%, quaternary ammonium salt-39 0.05%; Centella asiatica extract 0.1%; Portulaca oleracea extract 1%, potassium cocoyl glycinate 15%, sodium cocoylamphoacetate 1.5%, disodium lauryl sulfosuccinate 0.4%, glycerin 25%, acrylic acid (ester) copolymer 0.5%, sodium chloride 2%, glyceryl stearate SE 1%, H-833 1%, water to make up the balance to 100%;

[0062] Among them, Melaleuca alternifolia leaf oil and Mingyanjingqiao plant essence are used as acne-removing agents, niacinamide, PCA zinc and oil-control formula are used as oil-control agents, polyquaternium-39, Centella asiatica extract and Portulaca oleracea extract are used as conditioning agents, potassium cocoyl glycinate, sodium cocoylamphoacetate and disodium lauryl sulfosuccinate are used as cleansing agents, glycerin is used as a moisturizer, acrylic acid (ester) copolymer and sodium chloride are used as thickeners, and glyceryl stearate SE is used as an emulsifier. H-833 as a preservative;

[0063] The preparation method is the same as that of Example 2 to prepare an oil-controlling and anti-acne lotion.

[0064] Example 4: Preparation of oil-controlling acne-removing lotion:

[0065] (1) Raw material composition (mass percentage):

[0066] Melaleuca alternifolia leaf oil 0.5%, brightening and acne-clearing plant extract 1%, niacinamide 4%, PCA zinc 0.5%, oil control formula 1.5%, quaternium-39 0.01%, Centella asiatica extract 0.2%, Portulaca oleracea extract 0.5%, potassium cocoyl glycinate 20%, sodium cocoamphoacetate 1%, disodium lauryl sulfosuccinate 1%, glycerin 15%, acrylic acid (ester) copolymer 1%, sodium chloride 1%, glyceryl stearate SE 2%, H-833 0.6%, water to make up the balance to 100%;

[0067] Among them, Melaleuca alternifolia leaf oil and Mingyanjingqiao plant essence are used as acne-removing agents, niacinamide, PCA zinc and oil-control formula are used as oil-control agents, polyquaternium-39, Centella asiatica extract and Portulaca oleracea extract are used as conditioning agents, potassium cocoyl glycinate, sodium cocoylamphoacetate and disodium lauryl sulfosuccinate are used as cleansing agents, glycerin is used as a moisturizer, acrylic acid (ester) copolymer and sodium chloride are used as thickeners, and glyceryl stearate SE is used as an emulsifier. H-833 as a preservative;

[0068] The preparation method is the same as that of Example 2 to prepare an oil-controlling and anti-acne lotion.

[0069] Example 5: Preparation of oil-controlling acne-removing lotion:

[0070] (1) Raw material composition (mass percentage):

[0071] Melaleuca alternifolia leaf oil 0.3%, brightening and acne-clearing plant extract 0.5%, niacinamide 2%, PCA zinc 0.5%, oil control formula 1.5%, quaternium-39 0.01%, Centella asiatica extract 0.2%, Portulaca oleracea extract 0.7%, potassium cocoyl glycinate 18%, sodium cocoamphoacetate 1%, disodium lauryl sulfosuccinate 1%, glycerin 20%, acrylic acid (ester) copolymer 0.7%, sodium chloride 1%, glyceryl stearate SE 1.3%, H-833 0.8%, water to make up the balance to 100%;

[0072] Among them, Melaleuca alternifolia leaf oil and Mingyanjingqiao plant essence are used as acne-removing agents, niacinamide, PCA zinc and oil-control formula are used as oil-control agents, polyquaternium-39, Centella asiatica extract and Portulaca oleracea extract are used as conditioning agents, potassium cocoyl glycinate, sodium cocoylamphoacetate and disodium lauryl sulfosuccinate are used as cleansing agents, glycerin is used as a moisturizer, acrylic acid (ester) copolymer and sodium chloride are used as thickeners, and glyceryl stearate SE is used as an emulsifier. H-833 as a preservative;

[0073] The preparation method is the same as that of Example 2 to prepare an oil-controlling and anti-acne lotion.

[0074] Example 6: Preparation of oil-controlling acne-removing lotion:

[0075] (1) Raw material composition (mass percentage):

[0076] Melaleuca alternifolia leaf oil 0.2%, brightening and acne-clearing plant extract 1%, niacinamide 4%, PCA zinc 1%, oil control formula 0.5%, quaternium-39 0.03%, Centella asiatica extract 0.15%, Portulaca oleracea extract 1%, potassium cocoyl glycinate 16%, sodium cocoamphoacetate 1.5%, disodium lauryl sulfosuccinate 0.5%, glycerin 18%, acrylic acid (ester) copolymer 0.7%, sodium chloride 1.3%, glyceryl stearate SE 1.8%, H-833 0.8%, water to make up the balance to 100%;

[0077] Among them, Melaleuca alternifolia leaf oil and Mingyanjingqiao plant essence are used as acne-removing agents, niacinamide, PCA zinc and oil-control formula are used as oil-control agents, polyquaternium-39, Centella asiatica extract and Portulaca oleracea extract are used as conditioning agents, potassium cocoyl glycinate, sodium cocoylamphoacetate and disodium lauryl sulfosuccinate are used as cleansing agents, glycerin is used as a moisturizer, acrylic acid (ester) copolymer and sodium chloride are used as thickeners, and glyceryl stearate SE is used as an emulsifier. H-833 as a preservative;

[0078] The preparation method is the same as that of Example 2 to prepare an oil-controlling and anti-acne lotion.

[0079] Comparative Example 1:

[0080] (1) Raw material composition (mass percentage):

[0081] Brightening and clearing acne plant essence 1%, niacinamide 3%, PCA zinc 0.5%, oil control formula 1%, quaternium-39 0.03%, Centella asiatica extract 0.2%, Portulaca oleracea extract 1%, potassium cocoyl glycinate 16%, sodium cocoamphoacetate 1.2%, disodium lauryl sulfosuccinate 0.5%, glycerin 20%, acrylic acid (ester) copolymer 0.5%, sodium chloride 1.3%, glyceryl stearate SE 1.5%, H-833 0.8%, water to make up the balance to 100%;

[0082] Among them, Mingyanjingqiao Plant Extract is used as an acne remover, niacinamide, PCA zinc and oil control formula are used as oil control agents, polyquaternium-39, Centella asiatica extract and Portulaca oleracea extract are used as conditioning agents, potassium cocoyl glycinate, sodium cocoylamphoacetate and disodium lauryl sulfosuccinate are used as cleansing agents, glycerin is used as a moisturizer, acrylic acid (ester) copolymer and sodium chloride are used as thickeners, and glyceryl stearate SE is used as an emulsifier. H-833 as a preservative;

[0083] (2) Preparation method:

[0084] Add potassium cocoyl glycinate, sodium cocoyl amphoacetate, disodium lauryl sulfosuccinate, glycerin, and glyceryl stearate SE to water, heat to 80° C., and stir; after they are completely dissolved, stop heating, add pre-dispersed acrylic acid (ester) copolymer and sodium chloride, stir, and cool to obtain a mixed solution;

[0085] After cooling to 40°C, H-833, brightening and acne-clearing plant essence, niacinamide, PCA zinc, oil-control formula, quaternary ammonium salt-39, Centella asiatica extract and Portulaca oleracea extract are added to the mixed solution and stirred to dissolve. After the material forms a paste, stirring is stopped and the oil-control and acne-clearing lotion is obtained after standing for 12 hours.

[0086] The difference between Comparative Example 1 and Example 2 is that only the brightening and acne-clearing plant extract is added to the acne-removing agent.

[0087] Comparative Example 2:

[0088] (1) Raw material composition (mass percentage):

[0089] Melaleuca alternifolia leaf oil 0.2%, niacinamide 3%, PCA zinc 0.5%, oil control formula 1%, quaternary ammonium salt-390.03%, Centella asiatica extract 0.2%, Portulaca oleracea extract 1%, potassium cocoyl glycinate 16%, sodium cocoamphoacetate 1.2%, disodium lauryl sulfosuccinate 0.5%, glycerin 20%, acrylic acid (ester) copolymer 0.5%, sodium chloride 1.3%, glyceryl stearate SE 1.5%, H-833 0.8%, water to make up the balance to 100%;

[0090] Among them, Melaleuca alternifolia leaf oil is used as an acne-removing agent, niacinamide, PCA zinc and oil-control formula are used as oil-control agents, polyquaternium-39, Centella asiatica extract and Portulaca oleracea extract are used as conditioning agents, potassium cocoyl glycinate, sodium cocoyl amphoacetate and disodium lauryl sulfosuccinate are used as cleansing agents, glycerin is used as a moisturizer, acrylic acid (ester) copolymer and sodium chloride are used as thickeners, and glyceryl stearate SE is used as an emulsifier. H-833 as a preservative;

[0091] (2) Preparation method:

[0092] Add potassium cocoyl glycinate, sodium cocoyl amphoacetate, disodium lauryl sulfosuccinate, glycerin, and glyceryl stearate SE to water, heat to 80° C., and stir; after they are completely dissolved, stop heating, add pre-dispersed acrylic acid (ester) copolymer and sodium chloride, stir, and cool to obtain a mixed solution;

[0093] After cooling to 40°C, H-833, Melaleuca alternifolia leaf oil, niacinamide, PCA zinc, oil-control formula, quaternary ammonium salt-39, Centella asiatica extract and Portulaca oleracea extract are added to the mixed solution and stirred to dissolve. After the material forms a paste, stirring is stopped and the oil-control and anti-acne lotion is obtained after standing for 12 hours.

[0094] The difference between Comparative Example 1 and Example 2 is that only Melaleuca alternifolia leaf oil is added to the anti-acne agent.

[0095] Comparative Example 3:

[0096] (1) Raw material composition (mass percentage):

[0097] Niacinamide 3%, PCA zinc 0.5%, oil control formula 1%, quaternium-39 0.03%, Centella asiatica extract 0.2%, Portulaca oleracea extract 1%, potassium cocoyl glycinate 16%, sodium cocoamphoacetate 1.2%, disodium lauryl sulfosuccinate 0.5%, glycerin 20%, acrylic acid (ester) copolymer 0.5%, sodium chloride 1.3%, glyceryl stearate SE 1.5%, H-833 0.8%, water to make up the balance to 100%;

[0098] Among them, niacinamide, PCA zinc and oil control formula are used as oil control agents, polyquaternium-39, Centella asiatica extract and purslane extract are used as conditioners, potassium cocoyl glycinate, sodium cocoyl amphoacetate and disodium lauryl sulfosuccinate are used as cleansing agents, glycerin is used as a moisturizer, acrylic acid (ester) copolymer and sodium chloride are used as thickeners, and glyceryl stearate SE is used as an emulsifier. H-833 as a preservative;

[0099] (2) Preparation method:

[0100] Add potassium cocoyl glycinate, sodium cocoyl amphoacetate, disodium lauryl sulfosuccinate, glycerin, and glyceryl stearate SE to water, heat to 80° C., and stir; after they are completely dissolved, stop heating, add pre-dispersed acrylic acid (ester) copolymer and sodium chloride, stir, and cool to obtain a mixed solution;

[0101] After cooling to 40°C, H-833, niacinamide, PCA zinc, oil-control formula, quaternary ammonium salt-39, Centella asiatica extract and Portulaca oleracea extract are added to the mixed solution and stirred to dissolve. After the material forms a paste, stirring is stopped and the oil-control and anti-acne lotion is obtained after standing for 12 hours.

[0102] The difference between this comparative example 1 and example 2 is that the anti-acne agent is omitted.

[0103] Comparative Example 4:

[0104] (1) Raw material composition (mass percentage):

[0105] Melaleuca alternifolia leaf oil 0.2%, brightening and acne-clearing plant essence 1%, oil control formula 1%, quaternary ammonium salt-39 0.03%, Centella asiatica extract 0.2%, Portulaca oleracea extract 1%, potassium cocoyl glycinate 16%, sodium cocoamphoacetate 1.2%, disodium lauryl sulfosuccinate 0.5%, glycerin 20%, acrylic acid (ester) copolymer 0.5%, sodium chloride 1.3%, glyceryl stearate SE 1.5%, H-833 0.8%, water to make up the balance to 100%;

[0106] Among them, Melaleuca alternifolia leaf oil and Mingyanjingqiao plant essence are used as acne removers, oil control formula is used as oil control agent, polyquaternium-39, Centella asiatica extract and Portulaca oleracea extract are used as conditioning agents, potassium cocoyl glycinate, sodium cocoylamphoacetate and disodium lauryl sulfosuccinate are used as cleansing agents, glycerin is used as a moisturizer, acrylic acid (ester) copolymer and sodium chloride are used as thickeners, and glyceryl stearate SE is used as an emulsifier. H-833 as a preservative;

[0107] (2) Preparation method:

[0108] Add potassium cocoyl glycinate, sodium cocoyl amphoacetate, disodium lauryl sulfosuccinate, glycerin, and glyceryl stearate SE to water, heat to 80° C., and stir; after they are completely dissolved, stop heating, add pre-dispersed acrylic acid (ester) copolymer and sodium chloride, stir, and cool to obtain a mixed solution;

[0109] After cooling to 40°C, H-833, Melaleuca alternifolia leaf oil, brightening and acne-clearing plant essence, oil-control formula, quaternary ammonium salt-39, Centella asiatica extract and Portulaca oleracea extract are added to the mixed solution and stirred to dissolve. After the material forms a paste, stirring is stopped and the oil-control and acne-clearing lotion is obtained after standing for 12 hours.

[0110] The difference between Comparative Example 1 and Example 2 is that only the oil-controlling formula is added to the oil-controlling agent.

[0111] Comparative Example 5:

[0112] (1) Raw material composition (mass percentage):

[0113] Melaleuca alternifolia leaf oil 0.2%, acne-clearing plant extract 1%, PCA zinc 0.5%, quaternium-39 0.03%, Centella asiatica extract 0.2%, Portulaca oleracea extract 1%, potassium cocoyl glycinate 16%, sodium cocoamphoacetate 1.2%, disodium lauryl sulfosuccinate 0.5%, glycerin 20%, acrylic acid (ester) copolymer 0.5%, sodium chloride 1.3%, glyceryl stearate SE 1.5%, H-833 0.8%, water to make up the balance to 100%;

[0114] Among them, Melaleuca alternifolia leaf oil and Mingyanjingqiao plant extract are used as acne-removing agents, PCA zinc is used as an oil-control agent, polyquaternium-39, Centella asiatica extract and Portulaca oleracea extract are used as conditioning agents, potassium cocoyl glycinate, sodium cocoylamphoacetate and disodium lauryl sulfosuccinate are used as cleansing agents, glycerin is used as a moisturizer, acrylic acid (ester) copolymer and sodium chloride are used as thickeners, and glyceryl stearate SE is used as an emulsifier. H-833 as a preservative;

[0115] (2) Preparation method:

[0116] Add potassium cocoyl glycinate, sodium cocoyl amphoacetate, disodium lauryl sulfosuccinate, glycerin, and glyceryl stearate SE to water, heat to 80° C., and stir; after they are completely dissolved, stop heating, add pre-dispersed acrylic acid (ester) copolymer and sodium chloride, stir, and cool to obtain a mixed solution;

[0117] After cooling to 40°C, H-833, Melaleuca alternifolia leaf oil, brightening and acne-clearing plant extract, PCA zinc, quaternary ammonium salt-39, Centella asiatica extract and Portulaca oleracea extract are added to the mixed solution and stirred to dissolve. After the material forms a paste, stirring is stopped and the oil-controlling and anti-acne lotion is obtained after standing for 12 hours.

[0118] The difference between Comparative Example 1 and Example 2 is that only PCA zinc is added to the oil control agent.

[0119] Comparative Example 6:

[0120] (1) Raw material composition (mass percentage):

[0121] Melaleuca alternifolia leaf oil 0.2%, acne-clearing plant extract 1%, niacinamide 3%, quaternium-39 0.03%, Centella asiatica extract 0.2%, Portulaca oleracea extract 1%, potassium cocoyl glycinate 16%, sodium cocoamphoacetate 1.2%, disodium lauryl sulfosuccinate 0.5%, glycerin 20%, acrylic acid (ester) copolymer 0.5%, sodium chloride 1.3%, glyceryl stearate SE 1.5%, H-833 0.8%, water to make up the balance to 100%;

[0122] Among them, Melaleuca alternifolia leaf oil and Mingyanjingqiao plant extract are used as acne removers, niacinamide is used as an oil control agent, polyquaternium-39, Centella asiatica extract and Portulaca oleracea extract are used as conditioning agents, potassium cocoyl glycinate, sodium cocoylamphoacetate and disodium lauryl sulfosuccinate are used as cleansing agents, glycerin is used as a moisturizer, acrylic acid (ester) copolymer and sodium chloride are used as thickeners, and glyceryl stearate SE is used as an emulsifier. H-833 as a preservative;

[0123] (2) Preparation method:

[0124] Add potassium cocoyl glycinate, sodium cocoyl amphoacetate, disodium lauryl sulfosuccinate, glycerin, and glyceryl stearate SE to water, heat to 80° C., and stir; after they are completely dissolved, stop heating, add pre-dispersed acrylic acid (ester) copolymer and sodium chloride, stir, and cool to obtain a mixed solution;

[0125] After cooling to 40°C, H-833, Melaleuca alternifolia leaf oil, brightening and acne-clearing plant essence, niacinamide, quaternary ammonium salt-39, Centella asiatica extract and Portulaca oleracea extract are added to the mixed solution and stirred to dissolve. After the material forms a paste, stirring is stopped and the oil-controlling and anti-acne lotion is obtained after standing for 12 hours.

[0126] The difference between Comparative Example 1 and Example 2 is that only niacinamide is added to the oil control agent.

[0127] Comparative Example 7:

[0128] (1) Raw material composition (mass percentage):

[0129] Melaleuca alternifolia leaf oil 0.2%, acne-clearing plant extract 1%, quaternium-39 0.03%, Centella asiatica extract 0.2%, Portulaca oleracea extract 1%, potassium cocoyl glycinate 16%, sodium cocoamphoacetate 1.2%, disodium lauryl sulfosuccinate 0.5%, glycerin 20%, acrylic acid (ester) copolymer 0.5%, sodium chloride 1.3%, glyceryl stearate SE 1.5%, H-833 0.8%, water to make up the balance to 100%;

[0130] Among them, Melaleuca alternifolia leaf oil and Mingyanjingqiao plant essence are used as acne-removing agents, polyquaternium-39, Centella asiatica extract and Portulaca oleracea extract are used as conditioning agents, potassium cocoyl glycinate, sodium cocoamphoacetate and disodium lauryl sulfosuccinate are used as cleansing agents, glycerin is used as a moisturizer, acrylic acid (ester) copolymer and sodium chloride are used as thickeners, and glyceryl stearate SE is used as an emulsifier. H-833 as a preservative;

[0131] (2) Preparation method:

[0132] Add potassium cocoyl glycinate, sodium cocoyl amphoacetate, disodium lauryl sulfosuccinate, glycerin, and glyceryl stearate SE to water, heat to 80° C., and stir; after they are completely dissolved, stop heating, add pre-dispersed acrylic acid (ester) copolymer and sodium chloride, stir, and cool to obtain a mixed solution;

[0133] After cooling to 40°C, H-833, Melaleuca alternifolia leaf oil, brightening and acne-clearing plant essence, quaternary ammonium salt-39, Centella asiatica extract and Portulaca oleracea extract are added to the mixed solution and stirred to dissolve. After the material forms a paste, stirring is stopped and the oil-controlling and anti-acne lotion is obtained after standing for 12 hours.

[0134] The difference between Comparative Example 1 and Example 2 is that the oil control agent is omitted.

[0135] Test Example 1: Antibacterial effect test of the composition for preventing and treating acne on Propionibacterium acnes:

[0136] 1. Test method:

[0137] The tested bacteria was Propionibacterium acnes.

[0138] The strain of Propionibacterium acnes has a collection number of CCTCC AB2011019 and was purchased from China Center for Type Culture Collection.

[0139] The diameter of the inhibition zone was measured using the agar punch method recommended by the National Committee for Clinical Laboratory Standards (NCCLS2020). 6 The bacterial suspension of 100 μL of CFU / mL was evenly coated on a solid plate, the oil-control and anti-acne composition prepared in Example 1 was mixed with water (final concentration was 10 mg / mL) and added to the agar wells prepared in advance, 80 μL of physiological saline was added as a negative control group, and the plate was covered. 100 μL of 10 μL of CFU / mL was taken with a micropipette 6 CFU / mL of the test strain suspension is applied to the surface of the agar medium, spread evenly with a sterile spreader, cover the plate, and place it in a 37°C constant temperature biochemical incubator for incubation. Observe the results after 48 hours. Repeat 3 times, measure the diameter of the inhibition zone and take the average value.

[0140] The strength of the antibacterial ability can be expressed by the diameter of the antibacterial zone. The antibacterial zone result judgment standard in the "Technical Specifications for Disinfection" is adopted: ≤10mm is low sensitivity; 10-14 is moderate sensitivity; 15-20 is high sensitivity; ≥20mm is extremely sensitive.

[0141] 2. Test results:

[0142] Table 1 Diameter of inhibition zone of oil-controlling and anti-acne composition against Propionibacterium acnes (mm)

[0143] Treatment Group Propionibacterium acnes Example 1 21.3 Comparative Example 1 11.2 Comparative Example 2 13.3 Comparative Example 3 5.5

[0144] As can be seen from Table 1, the oil-controlling and anti-acne composition prepared in Example 1 exhibits an extremely sensitive antibacterial effect on Propionibacterium acnes, and has a good prospect in preventing and treating acne.

[0145] Test Example 2: Human efficacy test evaluation:

[0146] A human efficacy test evaluation method was adopted, and the subjects were selected: 120 male and female subjects aged 18-60 years old were selected, with skin conditions such as easy redness on the face, excessive oil secretion, and acne lesions on the face, who met the voluntary selection criteria for the subjects.

[0147] Test equipment: German CK Cutometer dual MPA580, VISIA 7

[0148] Test environment: Temperature: 21.0℃±1.0℃; Humidity: 50%±10%

[0149] Test process: 120 subjects were divided into 12 groups, each with 10 subjects. The subjects were tested on the same facial area 28 days before and after the trial of the products. The evaluation indicators included domain a * Values, percentage of skin lesion reduction, transepidermal water loss rate, oil and transepidermal water loss rate were compared before and after to obtain the effect evaluation of different products.

[0150] 1.a * value:

[0151] a * Value, a skin color index, represents the redness and greenness of the skin. Positive numbers indicate redness, negative numbers indicate greenness, * The larger the value, the redder the skin color.

[0152] a * The value change rate represents the change in skin color before and after using the product. The greater the change in this value, the better the skin improvement. * Value, by trial before and after a * The difference in values ​​accounts for a before the trial * The percentage of the value is obtained * Value change rate.

[0153] a * Value change rate % = [(after trial a * Value-before-triala * Value) / before trial * value] × 100%.

[0154] 2. Skin lesion reduction percentage (ISGA score):

[0155] The ISGA score is used to assess the severity of skin damage and to score the degree of damage. A score of 0 indicates normal skin with no acne lesions, and a score of 5 indicates that the skin is dominated by a large number of inflammatory lesions, with varying numbers of comedones, papules, pustules, or nodules.

[0156] The percentage of skin lesion reduction represents the changes in skin lesions before and after the product trial. The skin lesions on the subject's face are assessed before and after the product trial. The percentage of skin lesion reduction after the subject's trial of the product is calculated by the ratio of the difference in ISGA scores before and after diagnosis to the ISGA score at the first visit.

[0157] Skin lesion reduction percentage (%) = [(ISGA score at first visit - ISGA score at follow-up visit) / ISGA score at first visit] × 100%.

[0158] 3. Transepidermal water loss (TEWL):

[0159] The transepidermal water loss rate (TEWL) refers to the amount of water that can evaporate through the stratum corneum from the skin surface. It is usually used to evaluate the skin's barrier function and water retention capacity. The smaller the value, the less water is lost through the skin and the better the barrier function of the stratum corneum.

[0160] The transepidermal water loss rate (TEWL) represents the change in transepidermal water loss before and after trying a product. The transepidermal water loss is measured on the same area of ​​the subject's face before and after the product trial. The transepidermal water loss rate of the subject's trial of the product is obtained by dividing the difference in the change in transepidermal water loss before and after the trial by the proportion of the transepidermal water loss before the trial.

[0161] Transepidermal water loss rate (%) = [(transepidermal water loss rate after trial - transepidermal water loss rate before trial) / transepidermal water loss rate before trial] × 100%.

[0162] 4. Grease change rate:

[0163] Oil directly reflects the oil content of the skin. The larger the value, the higher the oil content of the skin.

[0164] The oil change rate represents the changes in skin oil before and after trying a product. Skin oil levels are measured on the same area of ​​the subject's face before and after the product trial. The oil change rate of the subject's trial of the product is determined by the ratio of the difference in skin oil changes before and after the trial to the skin oil before the trial.

[0165] Oil change rate % = [(skin oil after trial - skin oil before trial) / skin oil before trial] × 100%.

[0166] 5. Self-evaluation of subjects: Conduct self-evaluation of the products of Examples 2-6 by subjects after trying the products.

[0167] Table 1 Human efficacy test results

[0168]

[0169]

[0170] From the data in Table 1, it can be seen that the product a prepared using Examples 2-6 *The value change is higher than that of the product prepared by the control group, indicating that the product of the present invention does have a significant skin improvement effect after being used for a period of time, the red area is reduced, and the skin tends to be healthy. Under the scientific ratio of the present invention, a good skin improvement effect is obtained, and the skin improvement effect of Example 1 is more significant than that of other embodiments; in terms of the percentage of skin lesion reduction, the embodiments and the comparative examples have a certain effect on skin damage repair, but the repair effect of Examples 2-6 is more obvious, and the skin lesion change rate is more than 50%. Among them, the mutual synergy between the components in Example 2 makes the effect of skin damage repair the best, and it is gentle and non-irritating. In terms of transepidermal water content change rate, the products prepared by Examples 2-6 have less skin water loss than the comparative example, have a good moisturizing effect, and can significantly increase the water content of the stratum corneum, which fully proves that the facial cleanser of the present invention can keep the skin moisturized while cleaning the skin; in terms of oil change rate, the products prepared by the embodiments and the comparative examples have a certain oil control effect, and the effect of Examples 2-6 is more excellent, all above 50%, which shows that in the system of the present invention, if the components are changed, the corresponding oil control effect becomes worse, so the synergistic effect between the components is indispensable.

[0171] Table 2 Self-assessment form for subjects

[0172]

[0173] Note: 5, 4, 3, 2, and 1 represent very good, good, fair, poor, and very poor respectively.

[0174] As shown in Table 2, the acne-removing and oil-controlling amino acid cleansing milks of Examples 2-6 of the present invention are liked and recognized by the subjects. The subjects all said that the acne-removing and oil-controlling amino acid cleansing milks of the present invention can reduce skin oil secretion, keep the skin lastingly fresh, and have a relatively superior effect of improving acne and acne marks, improving skin redness, gently cleansing, does not increase the burden on the skin barrier, and is friendly to acne skin. Examples 2-6 each have their own advantages, and users can choose a suitable formula for use according to different situations.

[0175] In summary, the oil-controlling and anti-acne cleanser of the present invention can achieve mild acne removal, antibacterial and anti-inflammatory effects under the action of multiple plant extracts, and is compounded with several cost-effective oil-control agents and conditioning agents with scientific proportions, synergistic effects, mildness and non-irritation, and significant oil-controlling and acne-removing effects.

[0176] The above description is only the preferred embodiment of the present application and is not intended to limit the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. An oil-controlling and acne-removing composition, characterized in that: The composition comprises the following components in parts by weight: 0.5-1.5 parts of anti-acne agent, 3-7 parts of oil control agent, 0.5-1.5 parts of conditioning agent and 15-25 parts of moisturizer; The acne-removing agent is composed of Melaleuca alternifolia leaf oil and brightening and acne-clearing plant extract in a mass ratio of (0.1-0.5): (0.5-1.5); The oil control agent is composed of niacinamide, PCA zinc and an oil control formula in a mass ratio of (2-4): (0.5-1): (0.5-1.5).

2. The oil-controlling and anti-acne composition according to claim 1, characterized in that: The conditioning agent is composed of polyquaternium-39, centella asiatica extract and purslane extract in a mass ratio of (0.01-0.05): (0.1-0.2): (0.5-1).

3. Use of the oil-controlling and anti-acne composition according to claim 1 or 2 in the preparation of oil-controlling and anti-acne products.

4. The use according to claim 3, characterized in that: The product is any one of a cream, an emulsion, an aqueous solution, a gel, a facial mask or a lotion.

5. An oil-controlling and anti-acne lotion, characterized in that: The invention comprises the oil-controlling and anti-acne composition according to claim 1 or 2, wherein the addition amount of the oil-controlling and anti-acne composition is 15-40% of the mass of the oil-controlling and anti-acne lotion.

6. The oil-controlling and anti-acne lotion according to claim 5, characterized in that: The oil-controlling and anti-acne lotion also includes an auxiliary agent and water, wherein the auxiliary agent accounts for 20% to 30% of the mass of the oil-controlling and anti-acne lotion, and the remainder is water; the auxiliary agent is composed of a detergent, a thickener, an emulsifier and a preservative in a mass ratio of (16-23): (1.5-3): (1-2): (0.6-1.5).

7. The oil-controlling and anti-acne lotion according to claim 5, characterized in that: The cleaning agent is composed of potassium cocoyl glycinate, sodium cocoyl amphoacetate and disodium lauryl sulfosuccinate in a mass ratio of (15-20): (1-1.5): (0.4-1).

8. The oil-controlling and anti-acne lotion according to claim 5, characterized in that: The thickener is composed of acrylic acid (ester) copolymer and sodium chloride in a mass ratio of (0.5-1): (1-2).

9. The oil-controlling and anti-acne lotion according to claim 5, characterized in that: The emulsifier is glyceryl stearate SE, and the preservative is H-833.

10. The oil-controlling and anti-acne lotion according to claim 5, characterized in that: The oil-controlling acne-removing lotion is prepared by the following method: (1) adding a detergent, a moisturizer, and an emulsifier to water, heating to 80-85° C., and stirring; after the water is completely dissolved, stopping heating, adding a thickener dispersed in advance, stirring, and cooling to obtain a mixed solution; (2) After cooling to 40-45°C, add preservatives, acne removers, oil control agents, and conditioning agents to the mixed solution and stir to dissolve. After the material forms a paste, stop stirring and let it stand for 10-14 hours.

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