Polymer composite nanomaterial encapsulation system
The polymer synthesis technology encapsulates quantum dots or superparamagnetic iron oxide nanoparticles and binds antibodies to solve the problems of polymerization, low photochemical stability and insufficient specific binding ability in nanocomposite manufacturing, and achieves efficient and specific nanocomposite manufacturing.
CN119923563APending Publication Date: 2025-05-02CORE QUANTUM TECHNOLOGIES INC
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Patent Information
- Application Number
- CN202380064082.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Priority Date
- 2022-09-13
- Filing Date
- 2023-08-18
- Publication Date
- 2025-05-02
AI Technical Summary
Technical Problem
The prior art has problems such as conjugation, low photochemical stability, inconsistent particle size, insufficient brightness and lack of specificity for cell targets when manufacturing nanocomposites.
Method used
Using polymer synthesis technology, quantum dots (QDs) or superparamagnetic iron oxide nanoparticles (SPION) are encapsulated by polystyrene-b-polyethylene glycolamine (PS-b-PEG-NH2), binding to antibodies or antibody fragments to form nanocomplexes with specific binding capabilities.
Benefits of technology
Large-scale manufacturing of nanocomplexes with consistent particle size and high brightness is achieved, which improves the specific binding ability to cell targets, and simplifies the purification of nanocomplexes and the binding process of cell targets.
✦ Generated by Eureka AI based on patent content.
Abstract
In general, a polymeric nanomaterial encapsulation system can be used to manufacture polymer encapsulated nanoparticles, the polymer encapsulated nanoparticles comprising hydrophobic nanoparticles encapsulated in a hydrophobic region of the polymer, the hydrophobic region comprising a hydrophobic region of the polymer, the hydrophobic region comprising a hydrophobic region of the polymer, and a hydrophobic region of the polymer, the hydrophobic region comprising a hydrophobic region of the polymer. Wherein the outer hydrophilic region of the polymer ensures water solubility and provides functional groups, which can be used to make nanoparticle conjugates. In particular, particular examples include a polymeric nanoparticle structure comprising one or more of quantum dots and / or superparamagnetic iron oxide nanoparticles and / or upconverting nanoparticles encapsulated in polystyrene-b-polyethylene glycol amine, and / or one or more polymeric nanoparticles encapsulated in polystyrene-b-polyethylene glycol amine and / or one or more polymeric nanoparticles encapsulated in polystyrene-b-polyethylene glycol amine and / or one or more polymeric nanoparticles encapsulated in polystyrene-b-polyethylene glycol amine, and / or one or more polymeric nanoparticles encapsulated in polystyrene-b-polyethylene glycol amine. The method is used for manufacturing antibody conjugates which can be used for capturing cell targets.
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