Group A rotavirus G8P[8] strain CZ-23 and application thereof
By providing G8P[8] type A group rotavirus CZ-23, the problems of declining circulating strains and virus reassortment faced by existing rotavirus vaccines were solved, and a new virus strain was provided for vaccine development, which enhanced the protective effect of the vaccine.
CN120210133BActive Publication Date: 2026-06-12STATION OF VIRUS PREVENTION & CONTROL CHINA DISEASES PREVENTION & CONTROL CENT
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Patent Information
- Application Number
- CN202510704296.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2025-05-29
- Publication Date
- 2026-06-12
- Estimated Expiration
- 2045-05-29
AI Technical Summary
Technical Problem
Existing rotavirus vaccines face challenges in protective efficacy due to declining prevalent strains and viral reassortment, and lack diverse viral strains for vaccine development.
Method used
A strain of G8P[8] group A rotavirus CZ-23 with good genetic stability, encoding six structural and non-structural proteins, was provided for evaluation of the immunogenicity of existing vaccines and development of new vaccines.
Benefits of technology
This provides a new source of virus for rotavirus vaccines, enhances vaccine diversity and protective efficacy, and meets the needs of vaccine development.
✦ Generated by Eureka AI based on patent content.
Abstract
The present application relates to the technical field of rotavirus, and particularly relates to a G8P[8] type group A rotavirus CZ-23 and application thereof.A G8P[8] type group A rotavirus CZ-23 has been preserved in the China General Microbiological Culture Collection Center CGMCC on April 11, 2023, the address of the preservation center is No. 1, Xibaheyanli 3, Chaoyang District, Beijing, and the preservation number is CGMCC NO. 45559.The present application provides a new human rotavirus wild type strain, which is first reported to be isolated in China, the virus replication capacity of the strain is strong, the genetic stability is good, the strain can be applied to develop a vaccine strain of human rotavirus vaccine, and is suitable for a live attenuated rotavirus oral vaccine.
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