Traditional Chinese medicine composition with nerve soothing effect as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition with a nerve soothing effect and a preparation method and application thereof. The traditional Chinese medicine composition with the nerve soothing effect comprises the following raw materials in parts by weight: 25-35 parts of gastrodia elata, 15-25 parts of codonopsis pilosula, 15-25 parts of spina date seeds, 10-20 parts of poria cocos, 25-35 parts of rhizoma alismatis, 5-15 parts of lotus seeds, 10-20 parts of polygala tenuifolia and 5-10 parts of liquorice. The formula is found to have a good effect on soothing the nerves, stabilizing the mind and treating anxiety and insomnia through a proper ratio.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition with sedative effects, a preparation method thereof, and an application thereof. Background Art

[0002] Insomnia disorder (commonly known as "insomnia") is a disease centered around sleep difficulties. The clinical symptoms of insomnia mainly include difficulty falling asleep, frequent waking up at night, waking up early and being unable to fall asleep again, and feeling tired and inattentive after waking up. There are many causes that can trigger or contribute to insomnia, such as psychological stress, physical condition, drug effects, mental and physical illnesses, etc. Long-term insomnia may also lead to complications such as memory loss, mood swings, and decreased immunity.

[0003] Currently, the treatment of insomnia often adopts comprehensive methods, including psychotherapy (cognitive behavioral therapy), drug therapy (such as short-term use of sleeping pills, but it needs to follow doctor's advice), physical therapy (such as light therapy, music therapy), and traditional Chinese medicine conditioning, etc. Benzodiazepines and non-benzodiazepine sleeping pills are more commonly used in Western medicine clinics for insomnia patients. Although they have good hypnotic effects, their toxic and side effects cannot be underestimated. The most common ones are that these sleeping pills have addiction, drug resistance, daytime residual effects, motor and memory impairment, and liver and kidney toxicity, etc. In severe cases, it may lead to mental dysfunction. The main treatment methods of traditional Chinese medicine for insomnia are classical prescriptions or contemporary prescriptions and their modifications, self-prescribed prescriptions, proprietary Chinese medicines and traditional Chinese medicine preparations, syndrome differentiation prescriptions, and other traditional Chinese medicine characteristics (acupuncture, massage, acupoint application, etc.) treatments. Modern medical experts' treatment of insomnia mostly focuses on the theory of yin and yang, starting from the zang-fu organs, attaching importance to the relationship between insomnia and the zang-fu organs, and conducting syndrome differentiation and treatment.

[0004] For example, Chinese Patent CN108617824 provides a preparation method of ginseng cranberry sleep-aid health tea, which specifically includes the following steps: (1) weighing raw materials by weight parts, including Codonopsis pilosula, Semen Ziziphi Spinosae, Poria cocos, Panax ginseng, Lotus seed, Chinese yam, Semen Ziziphi Jujubae, Arillus Longan, Pericarpium Citri Reticulatae, fresh cranberry, and rock sugar; (2) obtaining material A; (3) obtaining material B; (4) obtaining a decoction; (5) obtaining ginseng cranberry sleep-aid health tea; (6) packaging in vacuum bags, 6 g per bag, sterilizing, labeling, and obtaining the finished product; it can not only effectively avoid problems such as denaturation, loss, and reduction of pharmacological activity of the effective components of traditional Chinese medicine, effectively promote falling asleep, prolong the deep sleep time, significantly improve the sleep quality, have no toxic and side effects on the human body, the human body will not develop dependence, effectively invigorate the spleen and replenish qi, nourish blood and soothe the nerves, relieve palpitations and neurasthenia, effectively enhance the human memory, effectively resist aging, and enhance the human immune ability, and promote the skin to be tender, smooth and elastic.

[0005] As disclosed in Chinese Patent CN117546926A, a dehumidifying and sleep-aiding tea and its preparation method are provided, which are made from the following raw materials in the following proportions: 10 - 20 parts of Ophiopogon japonicus, lotus seeds or lilies, 3 - 12 parts of lotus plumules, gardenia or bamboo leaves, 9 - 17 parts of wild jujube seeds, 6 - 15 parts of Prunella vulgaris, chrysanthemums or oysters, 12 - 20 parts of longans, 12 - 23 parts of dried tangerine peels, 8 - 15 parts of Pinellia ternata or Pogostemon cablin, 9 - 20 parts of Caulis Polygoni Multiflori or longans, 12 - 19 parts of Poria cocos, 10 - 18 parts of Poria cum Radix Pini or wild jujube seeds, 3 - 11 parts of dried ginger, 4 - 12 parts of Semen Platycladi, mulberries or donkey-hide gelatin, 2 - 10 grams of Angelica sinensis, black sesame seeds or Polygonatum sibiricum, 4 - 11 parts of Gastrodia elata, Angelica dahurica or Ligusticum chuanxiong, 5 - 15 parts of Codonopsis pilosula, Amomum villosum or Dioscorea opposita. The invention also discloses the preparation method of the dehumidifying and sleep-aiding tea. The dehumidifying and sleep-aiding tea prepared by the invention has a unique fragrance and is mellow and smooth, and has the effects of calming the nerves, removing dampness, relieving poor appetite, sticky mouth and tastelessness, and anxiety.

[0006] The above-mentioned inventions all have good curative effects on sleep, but their compositions are complex, and the curative effects on insomnia caused by depression and anxiety remain to be studied. Therefore, there is an urgent need to study a traditional Chinese medicine composition with simple ingredients and significant curative effects on insomnia caused by depression and anxiety. Summary of the Invention

[0007] Based on the deficiencies of the existing technology, the present invention aims to provide a traditional Chinese medicine composition with the function of calming the nerves, its preparation method and application.

[0008] The formula explanation of the present invention is as follows: Gastrodia elata: sweet in taste, neutral in nature; belonging to the liver meridian. It has the effects of calming endogenous wind and stopping convulsions, suppressing the hyperactive liver-yang, and dispelling wind and dredging collaterals.

[0009] Codonopsis pilosula: sweet in taste, neutral in nature; belonging to the spleen and lung meridians. It has the effects of invigorating the middle energizer and replenishing qi, relieving thirst, strengthening the spleen and nourishing the lung, and nourishing blood and promoting the production of body fluid. It is used for qi deficiency of the spleen and lung, anorexia and fatigue, cough with deficiency asthma, insufficient qi and blood, sallow complexion, palpitation and shortness of breath, thirst due to fluid deficiency, and internal heat and polydipsia.

[0010] Wild jujube seeds: sweet in taste, neutral in nature; belonging to the heart, spleen, liver and gallbladder meridians. It can nourish the liver, calm the mind, soothe the nerves and arrest sweating. It is used to treat insomnia due to deficiency and restlessness, palpitation and anxiety, polydipsia, and night sweats.

[0011] Poria cocos: sweet and light in taste, neutral in nature. Belonging to the heart, lung, spleen and kidney meridians. It is used for oliguria with edema, dizziness and palpitation due to retention of phlegm-fluid, anorexia due to spleen deficiency, loose stools and diarrhea, restlessness of the mind, palpitation and insomnia.

[0012] Alisma orientale: sweet and light in taste, cold in nature. Belonging to the kidney and bladder meridians. It can promote diuresis and remove dampness, purge heat, and reduce turbidity and lipid. It is used for dysuria, edema and fullness, diarrhea with oliguria, dizziness and palpitation due to retention of phlegm-fluid, acute urinary tract infection with pain, and hyperlipidemia.

[0013] Lotus seeds: sweet and astringent in taste, neutral in nature. Belonging to the spleen, kidney and heart meridians. It can tonify the spleen and stop diarrhea, arrest leucorrhea, astringe the kidney and reduce spermatorrhea, and nourish the heart and soothe the nerves.

[0014] Polygala tenuifolia: Bitter, pungent, warm. It acts on the heart, kidney, and lung meridians. Soothes the nerves, improves intelligence, and relieves depression. Treats palpitation, amnesia, spermatorrhea, insomnia, excessive phlegm in cough, carbuncles and sores.

[0015] Licorice: Sweet in taste, neutral in nature, acting on the heart, lung, spleen, and stomach meridians. As the main drug, it can replenish qi and benefit the middle energizer, relieve spasm and pain, moisten the lungs and arrest cough, purge fire and detoxify; as a harmonizing agent, it can harmonize various drugs, alleviate the potency and toxicity of other medicinal materials, and reduce the bitterness and pungency of the medicinal preparation. It is mainly used to treat lassitude, poor appetite, palpitation, shortness of breath, abdominal pain, loose stools, pain in the limbs, cough and asthma, sore throat, drug and food poisoning, etc.

[0016] To achieve the above object, the present invention adopts the following technical solutions: On the one hand, the present invention provides a traditional Chinese medicine composition with the function of soothing the nerves, which comprises the following raw materials in parts by weight: 25 - 35 parts of Gastrodia elata, 15 - 25 parts of Codonopsis pilosula, 15 - 25 parts of Ziziphus jujuba var. spinosa, 10 - 20 parts of Poria cocos, 25 - 35 parts of Alisma orientale, 5 - 15 parts of Nelumbo nucifera, 10 - 20 parts of Polygala tenuifolia, and 5 - 10 parts of Licorice.

[0017] Preferably, the traditional Chinese medicine composition with the function of soothing the nerves comprises the following raw materials in parts by weight: 30 parts of Gastrodia elata, 20 parts of Codonopsis pilosula, 20 parts of Ziziphus jujuba var. spinosa, 15 parts of Poria cocos, 30 parts of Alisma orientale, 10 parts of Nelumbo nucifera, 15 parts of Polygala tenuifolia, and 8 parts of Licorice.

[0018] Preferably, the mass ratio of Gastrodia elata to Codonopsis pilosula is 1 - 2:1, preferably 1.5:1.

[0019] Preferably, the mass ratio of Alisma orientale to Nelumbo nucifera is 5 - 6:1 - 2, preferably 3:1.

[0020] Preferably, the mass ratio of Ziziphus jujuba var. spinosa to Poria cocos is 3 - 4:2 - 3, preferably 4:3.

[0021] On the other hand, the present invention also provides a preparation method of the above traditional Chinese medicine composition with the function of soothing the nerves, which comprises the following steps: (1) Take the formula amounts of Gastrodia elata and Codonopsis pilosula, mix them, pulverize, and sieve to obtain mixed powder 1; (2) Add ethanol to the mixed powder 1 obtained in step (1), reflux and extract, filter to obtain filtrate A and residue A; (3) Take the formula amounts of Ziziphus jujuba var. spinosa, Poria cocos, Alisma orientale, Nelumbo nucifera, Polygala tenuifolia, and Licorice, mix them, pulverize, and sieve to obtain mixed powder 2; (4) Add ethanol to the mixed powder 2 obtained in step (3), reflux and extract, filter to obtain filtrate B and residue B; (5) Mix filtrate A and B obtained in step (2) and step (4), concentrate, and dry to obtain the traditional Chinese medicine composition.

[0022] Preferably, the mesh number of sieving in step (1) is 60 - 100 meshes, preferably 80 meshes.

[0023] Preferably, the volume fraction of ethanol in step (2) is 85% - 95%, the volume of ethanol is 4 - 6 times the total weight of gastrodia elata and codonopsis pilosula, and the reflux extraction time is 1 - 2 h.

[0024] More preferably, the volume fraction of ethanol in step (2) is 90%, the volume of ethanol is 5 times the total weight of gastrodia elata and codonopsis pilosula, and the reflux extraction time is 2 h.

[0025] Preferably, the mesh number of sieving in step (3) is 100 - 200 meshes, preferably 150 meshes.

[0026] Preferably, the volume fraction of ethanol in step (3) is 85% - 95%, the volume of ethanol is 4 - 6 times the total weight of semen ziziphi spinosae, poria cocos, alisma orientale, lotus seeds, polygala tenuifolia and licorice, and the reflux extraction time is 1 - 2 h.

[0027] More preferably, the volume fraction of ethanol in step (3) is 90%, the volume of ethanol is 5 times the total weight of semen ziziphi spinosae, poria cocos, alisma orientale, lotus seeds, polygala tenuifolia and licorice, and the reflux extraction time is 2 h.

[0028] Preferably, the concentration in step (5) is carried out by reduced pressure concentration, the temperature of the reduced pressure concentration is 50 - 65 °C, and the reduced pressure concentration is carried out until the solid content is 60 - 80%; More preferably, the temperature of the reduced pressure concentration in step (5) is 60 °C, and the reduced pressure concentration is carried out until the solid content is 70%.

[0029] Preferably, the drying in step (5) is vacuum drying, the drying time is 4 - 6 h, preferably 5 h.

[0030] Finally, the present invention also provides the application of the above traditional Chinese medicine composition in the preparation of drugs for calming the mind and relieving uneasiness.

[0031] Preferably, the dosage form of the drug is decoction, pill, powder, plaster or capsule.

[0032] Preferably, the drug also includes pharmaceutically acceptable excipients.

[0033] Compared with the prior art, the present invention has the following beneficial effects: In the present invention, gastrodia elata and codonopsis pilosula are used as monarch drugs, semen ziziphi spinosae, poria cocos, alisma orientale, lotus seeds and polygala tenuifolia are used as ministerial drugs, and licorice is used as adjuvant and guiding drug. It is unexpectedly found through appropriate proportioning that the formula has good effects on calming the mind and relieving uneasiness, and treating anxiety and insomnia. Detailed implementation manners

[0034] The technical solutions of the present invention will be clearly and completely described below in specific embodiments. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts belong to the scope of protection of the present invention. The materials, reagents, etc. used, unless otherwise specified, are reagents and materials that can be obtained from commercial channels.

[0035] Example 1 A traditional Chinese medicine composition with a calming effect The difference from Example 1 lies in: Gastrodia elata 30 parts, Codonopsis pilosula 20 parts, Ziziphus jujuba var. spinosa 20 parts, Poria cocos 15 parts, Alisma orientale 30 parts, Nelumbo nucifera 10 parts, Polygala tenuifolia 15 parts, and Glycyrrhiza uralensis 8 parts.

[0036] Example 2 A traditional Chinese medicine composition with a calming effect The difference from Example 1 lies in: Gastrodia elata 25 parts, Codonopsis pilosula 15 parts, Ziziphus jujuba var. spinosa 15 parts, Poria cocos 10 parts, Alisma orientale 25 parts, Nelumbo nucifera 5 parts, Polygala tenuifolia 10 parts, and Glycyrrhiza uralensis 5 parts.

[0037] Example 3 A traditional Chinese medicine composition with a calming effect The difference from Example 1 lies in: Gastrodia elata 35 parts, Codonopsis pilosula 25 parts, Ziziphus jujuba var. spinosa 25 parts, Poria cocos 20 parts, Alisma orientale 35 parts, Nelumbo nucifera 15 parts, Polygala tenuifolia 20 parts, and Glycyrrhiza uralensis 10 parts.

[0038] Comparative Example 1 The difference from Example 1 lies in: changing the mass ratio of Gastrodia elata and Codonopsis pilosula to 1:3, that is: Gastrodia elata 10 parts, Codonopsis pilosula 30 parts, Ziziphus jujuba var. spinosa 20 parts, Poria cocos 15 parts, Alisma orientale 30 parts, Nelumbo nucifera 10 parts, Polygala tenuifolia 15 parts, and Glycyrrhiza uralensis 8 parts.

[0039] Comparative Example 2 The difference from Example 1 lies in: changing the mass ratio of Alisma orientale and Nelumbo nucifera to 1:3, that is: Gastrodia elata 30 parts, Codonopsis pilosula 20 parts, Ziziphus jujuba var. spinosa 20 parts, Poria cocos 15 parts, Alisma orientale 10 parts, Nelumbo nucifera 30 parts, Polygala tenuifolia 15 parts, and Glycyrrhiza uralensis 8 parts.

[0040] Comparative Example 3 The difference from Example 1 lies in: changing the mass ratio of Ziziphus jujuba var. spinosa and Poria cocos to 1:4, that is: Gastrodia elata 30 parts, Codonopsis pilosula 20 parts, Ziziphus jujuba var. spinosa 10 parts, Poria cocos 40 parts, Alisma orientale 30 parts, Nelumbo nucifera 10 parts, Polygala tenuifolia 15 parts, and Glycyrrhiza uralensis 8 parts.

[0041] The above Examples 1-3 and Comparative Examples 1-3 were prepared according to the following method: (1) Take the formulated amounts of Gastrodia elata and Codonopsis pilosula, mix them, pulverize them, and sieve them through 80 meshes to obtain mixed powder 1; (2) Add the mixed powder 1 obtained in step (1) to ethanol with a volume fraction of 90%. The volume of ethanol added is 5 times the total weight of gastrodia elata and codonopsis pilosula. Reflux and extract for 2 h, then filter to obtain filtrate A and residue A; (3) Take the formula amount of ziziphus jujuba seeds, poria cocos, alisma orientale, lotus seeds, polygala tenuifolia, and licorice, mix them, pulverize, and sieve through 150 meshes to obtain mixed powder 2; (4) Add the mixed powder 2 obtained in step (3) to ethanol with a volume fraction of 90%. The volume of ethanol added is 5 times the total weight of ziziphus jujuba seeds, poria cocos, alisma orientale, lotus seeds, polygala tenuifolia, and licorice. Reflux and extract for 2 h, then filter to obtain filtrate B and residue B; (5) Mix filtrates A and B obtained in steps (2) and (4), and concentrate under reduced pressure at 60 °C until the solid content is 70%, then dry under reduced pressure for 5 h to obtain the described traditional Chinese medicine composition.

[0042] Comparative Example 4 The difference from Example 1 is as follows: The preparation method is different, specifically as follows: (1) Take the formula amount of gastrodia elata, codonopsis pilosula, ziziphus jujuba seeds, poria cocos, alisma orientale, lotus seeds, polygala tenuifolia, and licorice, mix them, pulverize, and sieve through 150 meshes to obtain mixed powder 1; (2) Add the mixed powder 1 obtained in step (1) to ethanol with a volume fraction of 90%. The volume of ethanol added is 5 times the total weight of gastrodia elata, codonopsis pilosula, ziziphus jujuba seeds, poria cocos, alisma orientale, lotus seeds, polygala tenuifolia, and licorice. Reflux and extract for 2 h, then filter to obtain filtrate C and residue C; (3) Concentrate filtrate C obtained in step (2) under reduced pressure at 60 °C until the solid content is 70%, then dry under reduced pressure for 5 h to obtain the described traditional Chinese medicine composition.

[0043] Comparative Example 5 The difference from Example 1 is as follows: Replace gastrodia elata with pheretima aspergillum, and the rest is the same as in Example 1. The preparation method is as follows: (1) Take the formula amount of pheretima aspergillum and codonopsis pilosula, mix them, pulverize, and sieve through 80 meshes to obtain mixed powder 1; (2) Add the mixed powder 1 obtained in step (1) to ethanol with a volume fraction of 90%. The volume of ethanol added is 5 times the total weight of gastrodia elata and codonopsis pilosula. Reflux and extract for 2 h, then filter to obtain filtrate A and residue A; (3) Take the formula amount of ziziphus jujuba seeds, poria cocos, alisma orientale, lotus seeds, polygala tenuifolia, and licorice, mix them, pulverize, and sieve through 150 meshes to obtain mixed powder 2; (4) Add the mixed powder 2 obtained in step (3) to ethanol with a volume fraction of 90%. The volume of ethanol added is 5 times the total weight of ziziphus jujuba seeds, poria cocos, alisma orientale, lotus seeds, polygala tenuifolia, and licorice. Reflux and extract for 2 h, then filter to obtain filtrate B and residue B; (5) Mix the filtrates A and B obtained in steps (2) and (4), concentrate under reduced pressure at 60 °C until the solid content is 70%, and dry under reduced pressure for 5 h to obtain the described traditional Chinese medicine composition.

[0044] Efficacy experiment 1. Effects of the composition on the sleep time of insomnia mice and the content of monoamine neurotransmitters in the brain tissue (1) Experimental grouping and preparation of animal models After Kunming mice adapted to the environment for 1 week, they were randomly divided into 10 groups according to body weight, namely the normal control group, the model group, and the traditional Chinese medicine compositions prepared in Examples 1-3 and Comparative Examples 1-4 of the present invention, with 10 mice in each group. Except for the normal control group, mice in the other groups were intraperitoneally injected with p-chlorophenylalanine suspension at 450 mg / kg every day for 2 consecutive days, and mice in the normal control group were intraperitoneally injected with an equal volume of normal saline. 28-30 h after the first intraperitoneal injection of p-chlorophenylalanine, mice in the normal control group slept well, were in good spirits, and showed no obvious changes; mice in the model group showed a certain degree of excitability, the circadian rhythm disappeared, their activities increased during the day, and their aggressiveness increased, showing significant differences from the normal control group. After the second intraperitoneal injection of p-chlorophenylalanine, the normal control group and the model group were intragastrically administered normal saline (at 2 ml / 100 g body weight), and the other groups were intragastrically administered the traditional Chinese medicine compositions prepared in Examples 1-3 and Comparative Examples 1-4 (the traditional Chinese medicine composition was made into a gavage liquid at 100 mg / ml by adding distilled water) respectively (at 2 ml / 100 g body weight). Gavage was performed once a day according to the above administration method for 7 consecutive days. (2) Experimental method Determination of sleep time by the righting reflex experiment: 60 min after gavage on the 6th day, mice in each group were intraperitoneally injected with pentobarbital sodium at 45 mg / kg, the sleep status of each group of mice was observed, and the sleep duration of the mice from the disappearance to the recovery of the righting reflex was calculated. Keep the environment quiet and ventilated during the experiment. Determination of monoamine neurotransmitters in the brain tissue: 24 h after the last administration, mice in each group were sacrificed by taking blood from the eye socket, the brain was quickly taken, rinsed with normal saline to remove blood stains, blotted dry with filter paper, weighed, placed in a -20 °C refrigerator for 15 min and then taken out, the hippocampal tissue of the mice was quickly dissected on an ice bath, weighed and wrapped with tin foil paper, and quickly placed in an -80 °C refrigerator for storage, to be measured. Accurately weigh the hippocampus of the brains of mice in each group, add 3 times the amount of 0.1 mol / L perchloric acid solution (containing 0.3 mmol disodium ethylenediaminetetraacetate and 0.5 mmol sodium sulfite), homogenize in an ice bath and immediately centrifuge at 4 °C and 14400×g for 15 min, and take the supernatant and place it in an HPLC auto-injection vial to obtain. Accurately weigh appropriate amounts of dopamine (DA) and 5-hydroxytryptamine (5-HT) reference standards, dissolve them in 0.1 mol / L perchloric acid solution, and prepare a reference standard stock solution with a concentration of 100 μg / ml. After serially diluting the above reference standard stock solution, inject them into a high-performance liquid chromatography (mobile phase: methanol and buffer solution in a ratio of 4:96 (containing 50 mmol of citric acid-sodium acetate, 1 mmol of B8 ion-pair reagent, 1.8 mmol of di-n-butylamine, 0.3 mmol of disodium ethylenediaminetetraacetate, pH 3.4), flow rate 1 mL / min, isocratic elution) - electrochemical detector (HPLC-ECD) system for detection.

[0045] (3)Experimental results The effects of the traditional Chinese medicine composition of the present invention on the sleep time of p-chlorophenylalanine-induced insomnia model mice are shown in Table 1; the effects on the content of monoamine neurotransmitters in the hippocampal tissue of insomnia model mice are shown in Table 2.

[0046] Table 1

[0047] Note: Compared with the model group, *p < 0.05, **p < 0.01; compared with the normal control group # p < 0.05, ## p < 0.01.

[0048] Table 2

[0049] Note: Compared with the model group, *p < 0.05, **p < 0.01; compared with the normal control group # p < 0.05, ## p < 0.01.

[0050] From the above data, it can be seen that the compositions prepared in Examples 1-3 can significantly prolong the sleep time of mice, improve the increase of DA and the decrease of 5-HT in the hippocampal tissue of mice. It is speculated that the mechanism of the traditional Chinese medicine composition provided by the present invention for treating insomnia may be related to inhibiting the content of DA in the brain of insomnia model mice and increasing the content of 5-HT, and may play a role in promoting sleep by regulating the level of neurotransmitters in the brain.

[0051] The above detailed description is a specific description of one feasible embodiment of the present invention. This embodiment is not intended to limit the patent scope of the present invention. Any equivalent implementation or modification without departing from the present invention should be included within the scope of the technical solution of the present invention.

Claims

1. A traditional Chinese medicine composition with the function of soothing the nerves, characterized in that, By weight parts, it comprises the following raw materials: 25 - 35 parts of Gastrodia elata, 15 - 25 parts of Codonopsis pilosula, 15 - 25 parts of Ziziphus jujuba var. spinosa, 10 - 20 parts of Poria cocos, 25 - 35 parts of Alisma orientale, 5 - 15 parts of Nelumbo nucifera Gaertn., 10 - 20 parts of Polygala tenuifolia Willd. and 5 - 10 parts of Glycyrrhiza uralensis Fisch.

2. The traditional Chinese medicine composition according to claim 1, wherein The mass ratio of the Gastrodia elata and Codonopsis pilosula is 1 - 2:

1.

3. The traditional Chinese medicine composition according to claim 1, characterized in that, The mass ratio of the Alisma orientale and Nelumbo nucifera Gaertn. is 5 - 6:1 - 2.

4. The traditional Chinese medicine composition according to claim 1, wherein The mass ratio of the Ziziphus jujuba var. spinosa and Poria cocos is 3 - 4:2 - 3.

5. The traditional Chinese medicine composition according to claim 1, characterized in that By weight parts, it comprises the following raw materials: 30 parts of Gastrodia elata, 20 parts of Codonopsis pilosula, 20 parts of Ziziphus jujuba var. spinosa, 15 parts of Poria cocos, 30 parts of Alisma orientale, 10 parts of Nelumbo nucifera Gaertn., 15 parts of Polygala tenuifolia Willd. and 8 parts of Glycyrrhiza uralensis Fisch.

6. The preparation method of the traditional Chinese medicine composition according to any one of claims 1 - 5, comprising the following steps: (1) Take the formula amount of Gastrodia elata and Codonopsis pilosula, mix, pulverize, and sieve to obtain mixed powder 1; (2) Add ethanol to the mixed powder 1 obtained in step (1), reflux and extract, filter to obtain filtrate A and residue A; (3) Take the formula amount of Ziziphus jujuba var. spinosa, Poria cocos, Alisma orientale, Nelumbo nucifera Gaertn., Polygala tenuifolia Willd. and Glycyrrhiza uralensis Fisch., mix, pulverize, and sieve to obtain mixed powder 2; (4) Add ethanol to the mixed powder 2 obtained in step (3), reflux and extract, filter to obtain filtrate B and residue B; (5) Mix the filtrates A and B obtained in steps (2) and (4), concentrate, and dry to obtain the traditional Chinese medicine composition.

7. The preparation method according to claim 6, characterized in that The mesh number of the sieving in step (1) is 60 - 100 meshes; the mesh number of the sieving in step (3) is 100 - 200 meshes.

8. The preparation method according to claim 6, characterized in that, The volume fraction of the ethanol in step (2) is 85% - 95%, the volume of the ethanol is 4 - 6 times the total weight of Gastrodia elata and Codonopsis pilosula, and the reflux extraction time is 1 - 2 h.

9. The preparation method according to claim 6, characterized in that, The volume fraction of the ethanol in step (3) is 85% - 95%, the volume of the ethanol is 4 - 6 times the total weight of Ziziphus jujuba var. spinosa, Poria cocos, Alisma orientale, Nelumbo nucifera Gaertn., Polygala tenuifolia Willd. and Glycyrrhiza uralensis Fisch., and the reflux extraction time is 1 - 2 h.

10. The application of the traditional Chinese medicine composition according to any one of claims 1 - 5 or the traditional Chinese medicine composition prepared by the preparation method according to any one of claims 6 - 9 in the preparation of drugs for calming the mind and tranquilizing the spirit.

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