Core-shell microsphere device and microsphere manufacturing method

Abstract

The invention discloses a core-shell microsphere device and a microsphere manufacturing method, and relates to the technical field of biological medicines.The core-shell microsphere device comprises a propelling assembly, a mixing assembly and a light curing assembly.The propelling assembly comprises a first propeller, a second propeller and a third propeller which are used for extruding a core material, a core-shell material and a protective material respectively; a power device of the propelling assembly pushes an injector in a screw transmission mode to continuously extrude materials, so that the efficiency and the control precision are improved; the first propeller, the second propeller and the third propeller inject different materials into the mixing device, so that the three materials are sequentially coated, and the core-shell material and the protective material are sequentially coated outside the core material to form a finished product; the light curing assembly comprises a containing plate and a light source, a spirally-arranged curing channel is formed in the containing plate, the main pipe communicates with the curing channel, the light source can irradiate finished products located in the curing channel to achieve the curing function, and the control module is electrically connected with the propelling assembly and the mixing assembly.

Description

Technical Field

[0001] The present invention relates to the field of biomedical technologies, and particularly to a core-shell microsphere device and a method for manufacturing microspheres. Background Art

[0002] GelMa (gelatin-methacrylate) is a biomaterial obtained by chemically modifying gelatin, which combines the good biocompatibility and degradability of gelatin and the photocuring ability of the methacrylate component. GelMa is widely used in the biomedical field due to its unique properties, especially in tissue engineering and drug delivery systems. Existing core-shell microsphere devices extrude core-shell microspheres through injection and control the size of the extruded core-shell microspheres by the size of the needle. However, during the manufacturing process, the size of the extruded microspheres cannot be adjusted, the precision of the microspheres is insufficient, the microsphere size range cannot reach below 200 um, and during the extrusion process of the material, the injection is intermittent extrusion, resulting in insufficient extrusion efficiency. Summary of the Invention

[0003] The present invention aims to solve at least one of the technical problems existing in the prior art. For this purpose, the present invention provides a core-shell microsphere device and a method for manufacturing microspheres, which can flexibly adjust the size of the microspheres and improve the manufacturing efficiency.

[0004] A core-shell microsphere device according to an embodiment of the first aspect of the present invention includes: A propulsion assembly, including a first thruster, a second thruster, and a third thruster. The first thruster is used to extrude the core material, the second thruster is used to extrude the core-shell material, and the third thruster is used to extrude the protective material. The first thruster, the second thruster, and the third thruster are all provided with a power device and a syringe, and the power device drives the syringe through a screw transmission method to achieve the extrusion of different materials; A mixing assembly, including a main pipe, a first branch pipe, and a second branch pipe. The first branch pipe and the second branch pipe are both connected to the side wall of the main pipe. The injection part of the first thruster is connected to the main pipe, the injection part of the second thruster is connected to the first branch pipe, and the injection part of the third thruster is connected to the second branch pipe. Along the moving direction of the material in the main pipe, the first branch pipe is located upstream of the second branch pipe. The first thruster, the second thruster, and the third thruster inject different materials into the main pipe to sequentially coat the core material with the core-shell material and the protective material to form a finished product; A photocuring assembly, arranged on one side of the mixing assembly, including a placement plate and a light source. The light source is arranged at the bottom of the placement plate. The placement plate is internally provided with a curing channel arranged in a spiral shape. The main pipe is connected to the curing channel, and the light source can irradiate the finished product located in the curing channel to achieve the curing function; A control module, electrically connected to the propulsion assembly and the mixing assembly, and the control module can control the discharging speed of the first thruster, the second thruster, and the third thruster.

[0005] A core-shell microsphere device according to an embodiment of the first aspect of the present invention has at least the following beneficial effects: This embodiment is provided with a propulsion component, a mixing component, a photo-curing component, and a control module. The propulsion component includes a first thruster, a second thruster, and a third thruster, which are respectively used for extruding the core material, the core-shell material, and the protective material. The first thruster, the second thruster, and the third thruster are all provided with a power device and a syringe. The power device drives the syringe through a screw drive to realize the extrusion of different materials, which can continuously and accurately control the amount of the extruded material, is beneficial to improving the efficiency, and can effectively improve the control accuracy of the extruded material, so as to adjust the size of the extruded microspheres. The mixing component includes a main pipe, a first branch pipe, and a second branch pipe. The first branch pipe and the second branch pipe are both connected to the side wall of the main pipe. The injection part of the first thruster is connected to the main pipe, the injection part of the second thruster is connected to the first branch pipe, and the injection part of the third thruster is connected to the second branch pipe. Along the moving direction of the material in the main pipe, the first branch pipe is at the upstream of the second branch pipe. The first thruster, the second thruster, and the third thruster inject different materials into the main pipe, so that the three materials are coated in sequence, and the core material is coated with the core-shell material and the protective material in sequence to form a finished product, which can realize the continuous production of microspheres. The photo-curing component is arranged on one side of the mixing component and includes a receiving plate and a light source. The light source is arranged at the bottom of the receiving plate. The receiving plate is provided with a curing channel arranged in a spiral shape. The main pipe is connected to the curing channel. The light source can irradiate the finished product located in the curing channel to realize the curing function. The control module is electrically connected to the propulsion component and the mixing component. The control module can control the discharging speed of the first thruster, the second thruster, and the third thruster, and can improve the material extrusion accuracy, so as to control the size of the microspheres.

[0006] According to an embodiment of the first aspect of the present invention, the main pipe has a main channel, the first branch pipe has a first channel communicating with the main channel, the second branch pipe has a second channel communicating with the main channel, and the included angle between the first channel and the main channel is a first included angle, and the included angle between the second channel and the main channel is a second included angle.

[0007] According to an embodiment of the first aspect of the present invention, both the first included angle and the second included angle are not greater than 90°.

[0008] According to an embodiment of the first aspect of the present invention, the inner diameters of both the first channel and the second channel are not less than the inner diameter of the main channel, and the inner diameter of the second channel is not less than the inner diameter of the first channel.

[0009] According to an embodiment of the first aspect of the present invention, the main pipe has a needle tube inserted into the curing channel. The downstream of the curing channel has a discharging channel for discharging the finished product, and the bottom wall of the discharging channel is higher than the bottom wall of the curing channel.

[0010] According to an embodiment of the first aspect of the present invention, the power device is provided with a lead screw and a moving block. The lead screw is threadedly connected to the moving block, and the moving block is connected to the piston rod in the syringe. When the lead screw rotates, it can drive the moving block to move, thereby pushing the piston rod to eject the material.

[0011] According to an embodiment of the first aspect of the present invention, it further includes a machine table, and the propulsion assembly, the mixing assembly, and the light-curing assembly are all installed on the machine table.

[0012] According to an embodiment of the first aspect of the present invention, a cooling assembly and a storage are further provided on the machine table. The cooling assembly is communicated with the discharge channel, and the cooling assembly can cool the finished product.

[0013] According to an embodiment of the first aspect of the present invention, an observation assembly is provided on the machine table. The observation assembly includes an optical device and a lifting device. The lifting device is fixed on the machine table. The optical device is used to observe the state of the finished product in the syringe, and the lifting device can adjust the distance between the optical device and the syringe.

[0014] According to an embodiment of the second aspect of the present invention, a method for manufacturing microspheres is provided, including the aforementioned core-shell microsphere device, which includes a first propeller, a second propeller, and a third propeller, respectively used for extruding the core material, the core-shell material, and the protective material. It further includes a mixing assembly, a light-curing assembly, a cooling assembly, and a storage. The mixing assembly includes a main pipe, a first branch pipe, and a second branch pipe. The light-curing assembly includes a receiving plate provided with a curing channel. Among them, the following steps are included: Step 1: Sequentially turn on the third propeller, the second propeller, and the first propeller, and inject the protective material, the core-shell material, and the core material into the mixing assembly in sequence; Step 2: The core-shell material enters the main pipe from the first branch pipe, so that the core-shell material coats the outer periphery of the core material to form a semi-finished product. The semi-finished product moves downstream along the main pipe, and the protective material enters the main pipe from the second branch pipe and coats the outer periphery of the semi-finished product, thereby forming a finished product; Step 3: The finished product flows from the main pipe into the receiving plate of the light-curing assembly. The finished product moves along the curing channel, and the light source irradiates the finished product to realize the curing process of the finished product; Step 4: The finished product after the curing process moves from the light-curing assembly to the cooling assembly and enters the storage through the cooling assembly.

[0015] A method for manufacturing microspheres according to an embodiment of the second aspect of the present invention has at least the following beneficial effects: In this embodiment, by sequentially turning on the third thruster, the second thruster, and the first thruster, the protective material, the core-shell material, and the inner core material are sequentially injected into the mixing assembly, so that before the inner core material is injected into the mixing assembly, the core-shell material and the protective material have been respectively injected into the first branch pipe and the second branch pipe. Thus, after the inner core material is injected into the interior of the mixing assembly, it is wrapped by the core-shell material to form a semi-finished product. After the semi-finished product moves downstream of the main pipe, it is wrapped by the protective material, realizing the layer-by-layer wrapping of the three materials, and thus forming a finished product. Moreover, through the light-curing assembly and the cooling assembly, the finished product is further formed and placed in the storage. During this process, the materials can be automatically and continuously advanced to manufacture the finished product, which can significantly improve the production efficiency and ensure that the finished product has good quality.

[0016] Additional aspects and advantages of the present invention will be given in part in the following description, become apparent in part from the following description, or be learned through the practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] The following further describes the present invention in conjunction with the drawings and embodiments, where: Figure 1 An isometric view of a core-shell microsphere device in an embodiment of the first aspect of the present invention; Figure 2 is Figure 1 an enlarged view of A in Figure 3 A top view of the machine table in an embodiment of the first aspect of the present invention; Figure 4 is Figure 3 an enlarged view of B in Figure 5 A cross-sectional view of the mixing assembly in an embodiment of the first aspect of the present invention; Figure 6 An isometric view of the accommodation plate in an embodiment of the first aspect of the present invention; Figure 7 A cross-sectional view of the accommodation plate in an embodiment of the first aspect of the present invention; Figure 8 A cross-sectional view of a core-shell microsphere device in an embodiment of the first aspect of the present invention; Figure 9 is Figure 8 an enlarged view of C in

[0018] Reference numerals: Machine table 100; Hot air device 101; Cooling assembly 102; Storage 103; The first thruster 110; the second thruster 111; the third thruster 112; the power device 113; the lead screw 1131; the moving block 1132; the base 1133; the syringe 114; the piston rod 1141; The mixing assembly 120; the main pipe 121; the main channel 1211; the syringe needle 1212; the first axis 1213; the first branch pipe 122; the first channel 1221; the first included angle 1222; the second axis 1223; the second branch pipe 123; the second channel 1231; the second included angle 1232; the third axis 1233; The light curing assembly 130; the accommodating plate 131; the curing channel 132; the light source 133; the discharging channel 134; the light filtering plate 135; the blocking portion 136; The observation assembly 140; the lifting device 141; the optical device 142; the screw rod 143. Detailed implementation manners

[0019] The embodiments of the present invention will be described in detail below. Examples of the embodiments are shown in the drawings, where the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the drawings are exemplary and are only used to explain the present invention and should not be construed as a limitation of the present invention.

[0020] In the description of the present invention, it should be understood that for the orientation description, such as up, down, front, back, left, right, etc., the orientation or position relationship indicated is based on the orientation or position relationship shown in the drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as a limitation of the present invention.

[0021] In the description of the present invention, the meaning of several is one or more, the meaning of multiple is more than two, greater than, less than, exceeding, etc. are understood as not including the present number, and above, below, within, etc. are understood as including the present number. If the first and second are described only for the purpose of distinguishing technical features, they should not be construed as indicating or implying relative importance or implicitly indicating the quantity of the indicated technical features or implicitly indicating the sequence relationship of the indicated technical features.

[0022] In the description of the present invention, unless otherwise clearly defined, words such as setting, installing, connecting, etc. should be understood in a broad sense, and those skilled in the art can reasonably determine the specific meanings of the above words in the present invention in combination with the specific content of the technical solution.

[0023] Refer to Figure 1, in a core-shell microsphere device according to an embodiment of the present invention, it includes a machine platform 100, on which a propulsion component, a mixing component, a photo-curing component 130 and a control module are installed. The propulsion component includes a first propeller 110, a second propeller 111 and a third propeller 112, which are respectively used for extruding core materials, core-shell materials and protective materials. The first propeller 110, the second propeller 111 and the third propeller 112 are all provided with a power device 113 and a syringe 114. The power device 113 drives the syringe 114 through a screw 143 transmission method to realize the extrusion of different materials, which can continuously and accurately control the amount of extruded materials, is beneficial to improving efficiency, and can effectively improve the control accuracy of the extruded materials, so as to adjust the size of the extruded microspheres.

[0024] Specifically, referring to Figure 2 , the power device 113 includes a base 1133, a lead screw 1131 and a moving block 1132. The syringe 114 is installed on the base 1133. The moving block 1132 is slidably connected to the base 1133, and the lead screw 1131 is rotatably connected to the base 1133. The lead screw 1131 is threadedly connected to the moving block 1132. When the lead screw 1131 rotates, it can drive the moving block 1132 to move linearly. The moving block 1132 is connected to the piston rod 1141 in the syringe 114. When the lead screw 1131 rotates, it can drive the moving block 1132 to move, so as to push the piston rod 1141 to eject the material, so as to realize the continuous extrusion of the material and improve the control accuracy.

[0025] Referring to Figure 3 and Figure 4 , the mixing component includes a main pipe 121, a first branch pipe 122 and a second branch pipe 123. The first branch pipe 122 and the second branch pipe 123 are both communicated with the side wall of the main pipe 121. The injection part of the first propeller 110 is communicated with the main pipe 121. The injection part of the second propeller 111 is communicated with the first branch pipe 122. The injection part of the third propeller 112 is communicated with the second branch pipe 123 (the connected pipes are not shown in the figure). Along the moving direction of the material in the main pipe 121, the first branch pipe 122 is located upstream of the second branch pipe 123. The first propeller 110, the second propeller 111 and the third propeller 112 inject different materials into the main pipe 121, so that the three materials are coated in sequence, and the core material is sequentially coated with the core-shell material and the protective material to form a finished product, and the continuous production of microspheres can be realized. It can be understood that the finished product is layer-by-layer wrapped with core materials, core-shell materials and protective materials. In this embodiment, at normal temperature and pressure, the core material is a liquid GelMa material, the core-shell material is a hydrogel material, and the protective material is a liquid vegetable oil.

[0026] It can be understood that, referring to Figure 5, there is a main channel 1211 inside the main pipe 121. The main channel 1211 runs through both ends of the main pipe 121. The first branch pipe 122 has a first channel 1221 communicating with the main channel 1211, and the second branch pipe 123 has a second channel 1231 communicating with the main channel 1211. It can be understood that during the production process of the finished product, under the push of the first thruster 110, the core material enters the main channel 1211 from one end of the main pipe 121. At this time, under the push of the second thruster 111 and the third thruster 112, the core-shell material enters the first channel 1221 from the first branch pipe 122 and enters the main channel 1211 from the first channel 1221, and the protective material enters the second channel 1231 from the second branch pipe 123 and enters the main channel 1211; when the core material moves to the intersection of the main channel 1211 and the first channel 1221, the core material can be embedded in the core-shell material, so that the core-shell material wraps around the outer periphery of the core material to form a semi-finished product. Further, when the semi-finished product continues to move downstream in the main channel 1211, when the semi-finished product moves to the intersection of the main channel 1211 and the second channel 1231, the semi-finished product can be embedded in the protective material, so that the protective material wraps around the outer periphery of the semi-finished product to form a finished product.

[0027] Refer to Figure 5 , it can be understood that the main channel 1211 extends in a straight line. A first axis 1213 is defined along the extension direction of the main channel 1211, a second axis 1223 is defined along the extension direction of the first channel 1221, and a third axis 1233 is defined along the extension direction of the second channel 1231. The included angle between the first channel 1221 and the main channel 1211 is the first included angle 1222, and the included angle between the second channel 1231 and the main channel 1211 is the second included angle 1232, that is, there is a first included angle 1222 between the first axis 1213 and the second axis 1223, and there is a second included angle 1232 between the first axis 1213 and the third axis 1233. It can be understood that along the moving direction of the core material, the openings of the first included angle 1222 and the second included angle 1232 face the downstream direction, and both the first included angle 1222 and the second included angle 1232 are not greater than 90°, that is, the first included angle 1222 and the second included angle 1232 can be set as right angles or acute angles. It can be understood that when the first included angle 1222 and the second included angle 1232 are not greater than 90°, it helps the core material to be embedded in the core-shell material and is beneficial for the semi-finished product to be embedded in the protective material, and can ensure the integrity of the wrapping of the core-shell material around the core material and the protective material around the semi-finished product, thus helping to improve the product quality.

[0028] It can be understood that the inner diameters of the first channel 1221 and the second channel 1231 are not less than the inner diameter of the main channel 1211, and the inner diameter of the second channel 1231 is not less than the inner diameter of the first channel 1221. Since the core material entering the main channel 1211 from the first thruster 110 has a certain size, the inner diameter of the first channel 1221 is not less than the inner diameter of the main channel 1211 to ensure that the core-shell material can completely cover the outer periphery of the core material. At the same time, the inner diameter of the second channel 1231 is not less than the inner diameter of the first channel 1221 to ensure that the protective material can completely cover the outer periphery of the semi-finished product, which helps to ensure the quality stability of the finished product.

[0029] It can be understood that the light-curing component 130 is arranged on one side of the mixing component and includes a placement plate 131 and a light source 133. The placement plate 131 is used to place the finished product. The light source 133 is arranged at the bottom of the placement plate 131. A curing channel 132 is arranged in the placement plate 131. Along the thickness direction of the placement plate 131, the curing channel 132 penetrates both sides of the placement plate 131. The main pipe 121 communicates with the curing channel 132. Specifically, the main pipe 121 has a syringe needle 1212 inserted into the curing channel 132, which can enable the finished product to enter the curing channel 132 along the syringe needle 1212. Refer to Figure 9 , a filter plate 135 is arranged between the light source 133 and the placement plate 131. The ultraviolet light emitted by the light source 133 is irradiated onto the curing channel 132 of the placement plate 131 through the filter plate 135, so that the light source 133 can irradiate the finished product located in the curing channel 132 to achieve the curing function.

[0030] Refer to Figure 6 , the curing channel 132 is spirally arranged on the placement plate 131. In this embodiment, along the radial direction of the placement plate 131, the number of turns of the spiral arrangement of the curing channel 132 is at least three, which helps to ensure that the curing channel 132 has sufficient length to ensure that the ultraviolet light fully contacts the finished product, thereby ensuring a good curing effect. Further, the curing channel 132 spirally extends from a position close to the outer side of the placement plate 131 towards the inside of the placement plate 131 to make full use of the surface area of the placement plate 131. Further, a discharge channel 134 for discharging the finished product is provided at the downstream of the curing channel 132. Refer to Figure 7, the discharge channel 134 runs through a plurality of curing channels 132 and extends outward from the receiving plate 131. The bottom wall of the discharge channel 134 is higher than the bottom wall of the curing channel 132. Moreover, blocking parts 136 are provided on both sides of the discharge channel 134 to prevent the finished products from directly entering from one side of the discharge channel 134 through the curing channel 132, thereby ensuring sufficient light curing time for the finished products and guaranteeing product quality. It can be understood that during the processing, as the number of finished products increases continuously, the finished products located in the receiving plate 131 accumulate continuously. Under the push of the propulsion assembly, the finished products located in the curing channel 132 can enter the discharge channel 134, thus completing the blanking step.

[0031] It can be understood that it further includes a control module. The control module is electrically connected to the propulsion assembly and the mixing assembly. The control module can control the discharge speeds of the first thruster 110, the second thruster 111, and the third thruster 112, and can improve the material extrusion accuracy, thereby realizing the control of the size of the microspheres.

[0032] It can be understood that a hot air device 101 is provided on the machine table 100. The hot air device 101 is provided with an air outlet that can blow out hot air. In this embodiment, the hot air device 101 is installed on the side wall of the machine table 100, and the air outlet is located between the propulsion assembly and the mixing assembly. During the processing, various materials are kept warm, thereby improving the fluidity of various materials, contributing to improving the processing efficiency and the quality of the finished products.

[0033] Furthermore, a cooling assembly 102 and a storage 103 are also provided on the machine table 100. The cooling assembly 102 is connected to the discharge channel 134 (the channel connecting the two is not shown in the drawings). The finished products that have completed the light curing process move from the discharge channel 134 to the cooling assembly 102. The cooling assembly 102 can cool the finished products, thereby further shaping the finished products. The storage 103 is connected to the cooling assembly 102 (the channel connecting the two is not shown in the drawings). The cooled finished products move to the storage 103 for storage, realizing the blanking process.

[0034] Refer to Figure 8 , an observation assembly 140 is provided on the machine table 100. The observation assembly 140 includes an optical device 142 and a lifting device 141. The lifting device 141 is fixed on the machine table 100. The optical device 142 is used to observe the state of the finished products in the syringe 1212. It can be understood that the syringe 1212 can be made of a transparent material. Moreover, the lifting device 141 is provided with a screw rod 143 that is threadedly connected to the optical device 142. The lifting device 141 rotates the screw rod 143 to adjust the height of the optical device 142, thereby realizing the adjustment of the distance between the optical device 142 and the syringe 1212 to adjust the focal length during observation.

[0035] In an embodiment of the second aspect of the present invention, a method for manufacturing microspheres is provided, including the aforementioned core-shell microsphere device, which includes the following steps: First, step 1: Sequentially turn on the third propeller 112, the second propeller 111, and the first propeller 110 in order, and inject a protective material, a core-shell material, and a core material into the mixing component in sequence. It can be understood that the discharge port of the first propeller 110 communicates with the main channel 1211, the discharge port of the second propeller 111 communicates with the first channel 1221, and the discharge port of the third propeller 112 communicates with the second channel 1231. Since the core material needs to be wrapped by the core-shell material and the protective material in sequence, before the core material enters the main channel 1211 from the first propeller 110 and reaches the intersection of the main channel 1211 and the first channel 1221, the intersection of the main channel 1211 and the first channel 1221 needs to have the core-shell material, so that the core material can be embedded in the core-shell material to form a semi-finished product after passing through the intersection of the main channel 1211 and the first channel 1221; similarly, before the semi-finished product reaches the intersection of the main channel 1211 and the second channel 1231, the intersection of the main channel 1211 and the second channel 1231 needs to have the protective material, so that the semi-finished product can be embedded in the protective material after passing through the intersection of the main channel 1211 and the second channel 1231, and then a finished product is formed. In some other embodiments, the third propeller 112 and the second propeller 111 can be turned on simultaneously, and then the first propeller 110 is turned on, which can also ensure that the core material is wrapped by the core-shell material and the protective material in sequence.

[0036] Secondly, after step 1 is completed, step 2 can be achieved: The core-shell material enters the main pipe 121 from the first branch pipe 122, so that the core-shell material covers the outer periphery of the core material to form a semi-finished product. The semi-finished product moves downstream along the main pipe 121, and the protective material enters the main pipe 121 from the second branch pipe 123 and covers the outer periphery of the semi-finished product, thereby forming a finished product.

[0037] Thirdly, step 3: The finished product flows from the main pipe 121 into the accommodation plate 131 of the light-curing component 130. The finished product moves along the curing channel 132, and the light source 133 irradiates the finished product to realize the curing process of the finished product, so that the finished product is cured and shaped to ensure the integrity of the product.

[0038] Finally, step 4: The finished product after the curing process moves from the light-curing component 130 to the cooling component 102 and enters the storage 103 through the cooling component 102. This process can manufacture the finished product by automatically and continuously advancing the materials, which can significantly improve the production efficiency and ensure that the finished product has good quality.

[0039] The embodiments of the present invention have been described in detail above with reference to the accompanying drawings. However, the present invention is not limited to the above embodiments, and various changes can be made without departing from the spirit of the present invention within the scope of knowledge possessed by those of ordinary skill in the relevant art.

Claims

1. A core-shell microsphere device, characterized in that, Comprising: A propulsion assembly, including a first thruster, a second thruster and a third thruster. The first thruster is used for extruding core materials, the second thruster is used for extruding core-shell materials, and the third thruster is used for extruding protective materials. The first thruster, the second thruster and the third thruster are all provided with power devices and syringes. The power devices push the syringes through screw drive to achieve the extrusion of different materials; A mixing assembly, including a main pipe, a first branch pipe and a second branch pipe. The first branch pipe and the second branch pipe are both connected to the side wall of the main pipe. The injection part of the first thruster is connected to the main pipe, the injection part of the second thruster is connected to the first branch pipe, and the injection part of the third thruster is connected to the second branch pipe. Along the moving direction of the materials in the main pipe, the first branch pipe is at the upstream of the second branch pipe. The first thruster, the second thruster and the third thruster inject different materials into the main pipe to sequentially coat the core materials with the core-shell materials and the protective materials to form finished products; A light-curing assembly, arranged on one side of the mixing assembly, including a receiving plate and a light source. The light source is arranged at the bottom of the receiving plate. A curing channel arranged in a spiral shape is provided in the receiving plate. The main pipe is connected to the curing channel. The light source can irradiate the finished products located in the curing channel to achieve the curing function; A control module, electrically connected to the propulsion assembly and the mixing assembly. The control module can control the discharging speeds of the first thruster, the second thruster and the third thruster.

2. The core-shell microsphere device according to claim 1, wherein, A main channel is provided in the main pipe. The first branch pipe has a first channel communicating with the main channel, and the second branch pipe has a second channel communicating with the main channel. The angle between the first channel and the main channel is a first angle, and the angle between the second channel and the main channel is a second angle.

3. The core-shell microsphere device according to claim 2, characterized in that, Both the first angle and the second angle are not greater than 90°.

4. A core-shell microsphere device according to claim 2, characterized in that, The inner diameters of the first channel and the second channel are not less than the inner diameter of the main channel, and the inner diameter of the second channel is not less than the inner diameter of the first channel.

5. A core-shell microsphere device according to claim 1, characterized in that, The main pipe has a needle tube inserted into the curing channel. A discharging channel for discharging the finished products is provided at the downstream of the curing channel. The bottom wall of the discharging channel is higher than the bottom wall of the curing channel.

6. The core-shell microsphere device according to claim 1, wherein, The power device is provided with a lead screw and a moving block. The lead screw is threadedly connected to the moving block. The moving block is connected to the piston rod in the syringe. When the lead screw rotates, it can drive the moving block to move, thereby pushing the piston rod to eject the materials.

7. A core-shell microsphere device according to claim 5, characterized in that, It further includes a machine table. The propulsion assembly, the mixing assembly and the light-curing assembly are all installed on the machine table.

8. A core-shell microsphere device according to claim 7, characterized in that, A cooling assembly and a storage are further provided on the machine table. The cooling assembly is connected to the discharging channel. The cooling assembly can cool the finished products.

9. The core-shell microsphere device according to claim 7, wherein, An observation assembly is provided on the machine table. The observation assembly includes an optical device and a lifting device. The lifting device is fixed to the machine table. The optical device is used to observe the state of the finished product in the syringe. The lifting device can adjust the distance between the optical device and the syringe.

10. A method for manufacturing microspheres, characterized in that, Applied to a core-shell microsphere device according to any one of claims 1 to 9, which includes a first propeller, a second propeller, and a third propeller, respectively used for extruding core material, core-shell material, and protective material, and further includes a mixing assembly, a photo-curing assembly, a cooling assembly, and a reservoir. The mixing assembly includes a main pipe, a first branch pipe, and a second branch pipe. The photo-curing assembly includes a receiving plate provided with a curing channel. Wherein, the following steps are included: Step 1: Sequentially turn on the third propeller, the second propeller, and the first propeller in sequence, and inject the protective material, the core-shell material, and the core material into the mixing assembly in sequence; Step 2: The core-shell material enters the main pipe from the first branch pipe, so that the core-shell material coats the outer periphery of the core material to form a semi-finished product. The semi-finished product moves downstream along the main pipe. The protective material enters the main pipe from the second branch pipe and coats the outer periphery of the semi-finished product, thereby forming a finished product; Step 3: The finished product flows from the main pipe into the receiving plate of the photo-curing assembly. The finished product moves along the curing channel, and the light source irradiates the finished product to realize the curing process of the finished product; Step 4: The finished product after the curing process moves from the photo-curing assembly to the cooling assembly and enters the reservoir through the cooling assembly.

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