Montmorillonite suspension and preparation method thereof

Abstract

The invention provides a montmorillonite suspension and a preparation method thereof, and relates to the field of pharmaceutical preparations. The suspending agent is prepared from the following raw materials in parts by weight: 1 to 2 parts of montmorillonite powder, 15 to 20 parts of suspending aid, 0.5 to 1 part of gelatin, 0.001 to 0.002 part of saccharin sodium salt, 0.01 to 0.02 part of glucose and 20 to 30 parts of water. According to the montmorillonite suspension provided by the invention, the gelatin is used as a shell to coat the montmorillonite powder so as to reduce the soil feeling and gravel feeling of oral administration of the montmorillonite suspension, and the coated montmorillonite powder, the gelatin on the surface and the suspending aid have a synergistic effect, so that the stability of the montmorillonite suspension is improved, and the sedimentation ratio of the montmorillonite suspension is close to 1.

Description

Technical Field

[0001] The present invention relates to the field of pharmaceutical preparations, and more particularly, to a montmorillonite suspension and a method for preparing the same. Background Art

[0002] Montmorillonite suspension is a commonly used drug for treating acute and chronic diarrhea, and its main component is montmorillonite powder. It is a physical antidiarrheal drug that exerts its antidiarrheal effect by adsorbing pathogens, toxins, and gases in the intestine and protecting the intestinal mucosa. It has high safety, and is hardly absorbed by the human body after oral administration (>99% is excreted with feces), so systemic side effects are extremely rare. It has a wide range of applicable populations and is an antidiarrheal drug suitable for pregnant women, lactating women, infants and young children (over 1 year old, those under 1 year old need to follow doctor's advice), and the elderly. Due to its selective adsorption property, it does not affect the normal intestinal flora, and montmorillonite has a weak adsorption effect on normal beneficial flora in the intestine (such as Bifidobacterium, Lactobacillus, etc.), and can better protect the intestinal microecological balance.

[0003] However, as an oral preparation, montmorillonite suspension (especially after the powder is brewed) has a taste similar to mud or powder, with a slight gritty feeling. Although the suspension is more acceptable than the powder, many patients (especially children) still find the taste bad and it is difficult to administer the medicine. Moreover, due to the swelling and water absorption of montmorillonite in water, the formed suspension is unstable and has poor dispersibility. Patent CN109718201A discloses a montmorillonite suspension for treating acute diarrhea and a method for preparing the same. Each milliliter of the montmorillonite suspension contains 100 mg of montmorillonite, 0.8 - 1.2 mg of sodium carboxymethylcellulose, and 1.6 - 2.4 mg of bacteriostatic agent; the particle size of the montmorillonite in the montmorillonite suspension is d(0.9)≤30μm, d(0.5)≤12μm; the viscosity of the sodium carboxymethylcellulose is 600 - 1200 mPa·s. It uses the concentration of sodium carboxymethylcellulose to reach an equilibrium state with the calcium cations exchangeable on the surface of montmorillonite, and has an anti-flocculation effect under this equilibrium state. The formed montmorillonite suspension has a qualified sedimentation volume ratio, is stable, and is easy to redisperse. However, in this patent, there is still a problem that the taste of the montmorillonite suspension is poor. Summary of the Invention

[0004] The purpose of the present invention is to provide a method for preparing a montmorillonite suspension. First, the montmorillonite powder is refined and treated by plasma to improve the hydrophilicity of the montmorillonite powder, and then coated with gelatin to reduce the earthy and gritty feeling of the montmorillonite suspension and improve the stability of the montmorillonite suspension.

[0005] Another purpose of the present invention is to provide a montmorillonite suspension. The montmorillonite suspension prepared by the method of the present invention has good stability and a comfortable taste.

[0006] The present invention solves its technical problems by adopting the following technical solutions.

[0007] On the one hand, an embodiment of the present invention provides a montmorillonite suspension, which includes the following raw materials by weight: 1-2 parts of montmorillonite powder, 15-20 parts of suspending agent, 0.5-1 part of gelatin, 0.001-0.002 parts of saccharin sodium, 0.01-0.02 parts of glucose, and 20-30 parts of water.

[0008] In some embodiments of the present invention, the suspending agent is a mixture of xanthan gum, sodium carboxymethyl cellulose, and sodium alginate, and the mass ratio of the three is 1:(0.5-0.8):(0.05-0.1).

[0009] In some embodiments of the present invention, the mass ratio of xanthan gum, sodium carboxymethyl cellulose, and sodium alginate is 1:0.5:0.05.

[0010] On the other hand, an embodiment of the present invention provides a preparation method of a montmorillonite suspension, which includes the following steps: S1, adding a dispersant to the montmorillonite powder, first performing high-speed shear dispersion treatment, then adding water and performing ultrasonic treatment, standing, taking the middle layer after stratification, drying, and pulverizing to obtain fine montmorillonite powder; S2, using oxygen as the working gas to perform plasma treatment on the fine montmorillonite powder obtained in step S1; S3, mixing the fine montmorillonite powder treated in step S2 with water, ultrasonically dispersing uniformly, heating to 40-50°C, adjusting the pH value to 8.5, then dropping an aqueous gelatin solution with a pH of 4.0, stirring evenly, cooling to 30-35°C, refrigerating, and then performing spray drying to obtain composite particles; S4, mixing the composite particles, suspending agent, saccharin sodium, glucose, and water in proportion, and ultrasonically dispersing uniformly to obtain the montmorillonite suspension.

[0011] In some embodiments of the present invention, in step S3, the mass fraction of the aqueous gelatin solution is 2-3%.

[0012] In some embodiments of the present invention, in step S2, the power density of the plasma treatment is 50-100 W / L; the treatment time is 5-10 min.

[0013] In some embodiments of the present invention, in step S4, the power density of the ultrasonic dispersion is 0.3-0.5 W / mL, the treatment time is 10-20 s, wherein, the ultrasonic treatment is 3-5 s, paused for 3-5 s, and repeated 3-5 times.

[0014] Compared with the prior art, the embodiments of the present invention have at least the following advantages or beneficial effects: The montmorillonite suspension provided by the present invention uses gelatin as the shell to coat the montmorillonite powder, so as to reduce the earthy and gritty feeling of the orally administered montmorillonite suspension. Moreover, for the coated montmorillonite powder, the gelatin on the surface and the suspending agent act synergistically to improve the stability of the montmorillonite suspension, and the sedimentation ratio of the montmorillonite suspension approaches 1.

[0015] The preparation method of the montmorillonite suspension provided by the present invention first performs wet grinding and dispersion on the montmorillonite powder to reduce the particle size of the montmorillonite powder, and then performs plasma treatment on the fine montmorillonite powder to graft hydrophilic groups on the surface of the montmorillonite powder to increase the reaction sites. Through coating treatment with gelatin as the shell and montmorillonite powder as the core, montmorillonite particles with a core-shell structure are obtained. Using the montmorillonite particles with a core-shell structure as the raw material, dispersion treatment is carried out with a suspending agent. After the suspending agent is dissolved in water, its long molecular chains stretch and occupy space through hydration, and entangle with each other to form a three-dimensional network structure. The gelatin molecules on the outer layer of the core-shell structure will absorb water and swell, and water molecules and the molecular chains of the suspending agent can enter the gelatin molecules to form a complex network structure, improving the stability of the suspension. Moreover, under the action of ultrasonic waves, the montmorillonite particles with a core-shell structure can be uniformly dispersed in the network structure of the suspending agent while maintaining the structure unchanged, improving the homogeneity and stability of the suspension. Detailed implementation manners

[0016] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. Those not specified in the embodiments are carried out according to conventional conditions or conditions recommended by the manufacturer. Those reagents or instruments not specified by the manufacturer can all be obtained as conventional products through commercial purchase.

[0017] It should be noted that, without conflict, the embodiments in the present invention and the features in the embodiments can be combined with each other. The present invention will be described in detail below with reference to specific embodiments.

[0018] On the one hand, an embodiment of the present invention provides a montmorillonite suspension, which includes the following raw materials by weight: 1-2 parts of montmorillonite powder, 15-20 parts of suspending agent, 0.5-1 part of gelatin, 0.001-0.002 part of sodium saccharin, 0.01-0.02 part of glucose, and 20-30 parts of water.

[0019] The suspending agent is a mixture of xanthan gum, sodium carboxymethyl cellulose, and sodium alginate, and the mass ratio of the three is 1:(0.5-0.8):(0.05-0.1). Preferably, the mass ratio of xanthan gum, sodium carboxymethyl cellulose, and sodium alginate is 1:0.5:0.05.

[0020] The preparation method of this montmorillonite suspension includes the following steps: S1. Add a dispersant to the montmorillonite powder, first perform high-speed shear dispersion treatment, then add water and perform ultrasonic treatment, let it stand, take the middle layer after stratification, dry it, and pulverize it to obtain fine montmorillonite powder; S2. Use the fine montmorillonite powder obtained in step S1, with oxygen as the working gas, to perform plasma treatment; the power density of the plasma treatment is 50 - 100 W / L; the treatment time is 5 - 10 min.

[0021] S3. Mix the fine montmorillonite powder treated in step S2 with water, ultrasonically disperse it evenly, heat it up to 40 - 50 °C, adjust the pH value to 8.5, then dropwise add a gelatin aqueous solution with a pH of 4.0, stir evenly, cool it down to 30 - 35 °C, refrigerate it, and then perform spray drying to obtain composite particles; among them, the mass fraction of the gelatin aqueous solution is 2 - 3%; S4. Mix the composite particles, suspending agent, saccharin sodium, glucose and water in proportion, ultrasonically disperse it evenly to obtain the montmorillonite suspension. Among them, the power density of the ultrasonic dispersion is 0.3 - 0.5 W / mL, the treatment time is 10 - 20 s, and among them, the ultrasonic treatment is 3 - 5 s, pause for 3 - 5 s, and repeat 3 - 5 times.

[0022] The features and properties of the present invention will be further described in detail below in conjunction with embodiments.

[0023] Example 1

[0024] Prepare each raw material according to the following ratio: 1 part of montmorillonite powder, 15 parts of suspending agent, 0.5 part of gelatin, 0.001 part of saccharin sodium, 0.01 part of glucose, 20 parts of water.

[0025] Prepare the montmorillonite suspension of this example according to the following method: S1. Add a dispersant (sodium hexametaphosphate solution, where the amount of sodium hexametaphosphate is 1% of the mass of the montmorillonite powder) to the montmorillonite powder, first perform high-speed shear dispersion treatment for 30 min, then add water and perform ultrasonic treatment for 10 min, let it stand, take the liquid of the middle layer after stratification, dry it, and grind and pulverize it to obtain fine montmorillonite powder; S2. Use the fine montmorillonite powder obtained in step S1, with oxygen as the working gas, a power density of 50 W / L, to perform plasma treatment for 10 min; S3. Mix the montmorillonite fine powder processed in step S2 with water. After ultrasonic dispersion until uniform, heat it to 50 °C, adjust the pH value to 8.5, then add dropwise a gelatin aqueous solution with a pH of 4.0 (mass fraction of 2%, temperature of 50 °C). After stirring evenly, cool it to 35 °C at a rate of 2 °C / min, refrigerate at -4 °C for 12 h, and then perform low-temperature spray drying (inlet air temperature 150 °C, outlet air temperature 60 °C, solid content of gelatin and montmorillonite powder is 8%) to obtain composite particles; S4. Mix the composite particles, suspending agent, saccharin sodium, glucose and water in proportion and disperse them evenly by ultrasonic treatment to obtain the montmorillonite suspension. Among them, the power density of ultrasonic dispersion is 0.3 W / mL and the treatment time is 20 s, where ultrasonic treatment is carried out for 5 s, paused for 5 s, and repeated 4 times.

[0026] Example 2

[0027] Prepare each raw material according to the following ratio: 2 parts of montmorillonite powder, 20 parts of suspending agent, 1 part of gelatin, 0.002 part of saccharin sodium, 0.02 part of glucose, 30 parts of water.

[0028] Prepare the montmorillonite suspension of this example according to the following method: S1. Add a dispersant (sodium hexametaphosphate solution, where the amount of sodium hexametaphosphate is 1% of the mass of montmorillonite powder) to the montmorillonite powder. First, perform high-speed shear dispersion treatment for 30 min, then add water and perform ultrasonic treatment for 10 min. Let it stand, take the liquid in the middle layer after stratification, dry it, grind and pulverize it to obtain montmorillonite fine powder; S2. Use oxygen as the working gas and a power density of 50 W / L to perform plasma treatment on the montmorillonite fine powder obtained in step S1 for 10 min; S3. Mix the montmorillonite fine powder processed in step S2 with water. After ultrasonic dispersion until uniform, heat it to 40 - 50 °C, adjust the pH value to 8.5, then add dropwise a gelatin aqueous solution with a pH of 4.0 (mass fraction of 2 - 3%, temperature of 50 °C). After stirring evenly, cool it to 35 °C at a rate of 2 °C / min, refrigerate at -4 °C for 10 h, and then perform low-temperature spray drying (inlet air temperature 150 °C, outlet air temperature 60 °C, solid content of gelatin and montmorillonite powder is 8%) to obtain composite particles; S4. Mix the composite particles, suspending agent, saccharin sodium, glucose and water in proportion and disperse them evenly by ultrasonic treatment to obtain the montmorillonite suspension. Among them, the power density of ultrasonic dispersion is 0.5 W / mL and the treatment time is 12 s, where ultrasonic treatment is carried out for 3 s, paused for 3 s, and repeated 4 times.

[0029] Example 3

[0030] Prepare each raw material according to the following ratio: Montmorillonite powder 1.5 parts, suspending agent 18 parts, gelatin 0.8 parts, sodium saccharin 0.0015 parts, glucose 0.015 parts, water 25 parts.

[0031] Prepare the montmorillonite suspension of this example according to the following method: S1. Add a dispersant (sodium hexametaphosphate solution, where the amount of sodium hexametaphosphate is 1% of the mass of the montmorillonite powder) to the montmorillonite powder. First, perform high-speed shear dispersion treatment for 30 min, then add water and perform ultrasonic treatment for 20 min. Let it stand, take the liquid in the middle layer after stratification, dry it, grind and pulverize it to obtain fine montmorillonite powder; S2. Use oxygen as the working gas and a power density of 100 W / L to perform plasma treatment on the fine montmorillonite powder obtained in step S1 for 5 min; S3. Mix the fine montmorillonite powder treated in step S2 with water, disperse it evenly by ultrasonic wave, heat it to 40 °C, adjust the pH value to 8.5, then dropwise add an aqueous gelatin solution with a pH of 4.0 (mass fraction 2 - 3%, temperature 50 °C), stir evenly, cool it to 30 °C at a rate of 2 °C / min, refrigerate it at -4 °C for 12 h, and then perform low-temperature spray drying (inlet air temperature 150 °C, outlet air temperature 60 °C, solid content of gelatin and montmorillonite powder 8%) to obtain composite particles; S4. Mix the composite particles, suspending agent, sodium saccharin, glucose and water in proportion, disperse them evenly by ultrasonic wave, and then the montmorillonite suspension is obtained. Among them, the power density of ultrasonic dispersion is 0.5 W / mL, and the treatment time is 20 s, where ultrasonic treatment is carried out for 5 s and paused for 5 s, repeating 4 times.

[0032] Example 4

[0033] Prepare each raw material according to the following ratio: Montmorillonite powder 1 part, suspending agent 15 parts, gelatin 0.5 parts, sodium saccharin 0.001 parts, glucose 0.01 parts, water 20 parts.

[0034] Prepare the montmorillonite suspension of this example according to the following method: S1. Add a dispersant (sodium hexametaphosphate solution, where the amount of sodium hexametaphosphate is 1% of the mass of the montmorillonite powder) to the montmorillonite powder. First, perform high-speed shear dispersion treatment for 30 min, then add water and perform ultrasonic treatment for 10 min. Let it stand, take the liquid in the middle layer after stratification, dry it, grind and pulverize it to obtain fine montmorillonite powder; S2. Use oxygen as the working gas and a power density of 100 W / L to perform plasma treatment on the fine montmorillonite powder obtained in step S1 for 10 min; S3. Mix the montmorillonite fine powder processed in step S2 with water. After ultrasonic dispersion until uniform, heat it up to 50 °C, adjust the pH value to 8.5, then add dropwise an aqueous gelatin solution with a pH of 4.0 (mass fraction of 3% and temperature of 50 °C). After stirring evenly, cool it down to 35 °C at a rate of 1 - 2 °C / min, refrigerate at -4 °C for 10 h, and then perform low-temperature spray drying (inlet air temperature 150 °C, outlet air temperature 60 °C, solid content of gelatin and montmorillonite powder is 8%) to obtain composite particles; S4. Mix the composite particles, suspending agent, saccharin sodium, glucose and water in proportion and disperse them evenly by ultrasonic wave to obtain the montmorillonite suspension. Among them, the power density of ultrasonic dispersion is 0.5 W / mL and the treatment time is 20 s, where ultrasonic treatment is carried out for 5 s and then paused for 5 s, repeating 4 times.

[0035] Example 5

[0036] Prepare each raw material according to the following ratio: 2 parts of montmorillonite powder, 20 parts of suspending agent, 1 part of gelatin, 0.002 part of saccharin sodium, 0.02 part of glucose, 30 parts of water.

[0037] Prepare the montmorillonite suspension of this example according to the following method: S1. Add a dispersant (sodium hexametaphosphate solution, where the amount of sodium hexametaphosphate is 1% of the mass of the montmorillonite powder) to the montmorillonite powder, first perform high-speed shear dispersion treatment for 30 min, then add water and perform ultrasonic treatment for 10 min, let it stand, take the liquid in the middle layer after stratification, dry it, grind and pulverize it to obtain montmorillonite fine powder; S2. Use oxygen as the working gas and a power density of 800 W / L to perform plasma treatment on the montmorillonite fine powder obtained in step S1 for 10 min; S3. Mix the montmorillonite fine powder processed in step S2 with water. After ultrasonic dispersion until uniform, heat it up to 40 - 50 °C, adjust the pH value to 8.5, then add dropwise an aqueous gelatin solution with a pH of 4.0 (mass fraction of 2 - 3% and temperature of 50 °C). After stirring evenly, cool it down to 35 °C at a rate of 2 °C / min, refrigerate at -4 °C for 10 h, and then perform low-temperature spray drying (inlet air temperature 150 °C, outlet air temperature 60 °C, solid content of gelatin and montmorillonite powder is 8%) to obtain composite particles; S4. Mix the composite particles, suspending agent, saccharin sodium, glucose and water in proportion and disperse them evenly by ultrasonic wave to obtain the montmorillonite suspension. Among them, the power density of ultrasonic dispersion is 0.5 W / mL and the treatment time is 12 s, where ultrasonic treatment is carried out for 3 s and then paused for 3 s, repeating 4 times.

[0038] Comparative Example 1 The difference from Example 1 is that 1 part of montmorillonite powder, 15 parts of suspending agent, 0.5 part of gelatin, 0.001 part of sodium saccharin, 0.01 part of glucose and 20 parts of water are directly mixed and ultrasonically dispersed evenly. Among them, the power density of ultrasonic dispersion is 0.3 W / mL and the treatment time is 20 s. Among them, ultrasonic treatment is carried out for 5 s, paused for 5 s, and repeated 4 times. That is, the montmorillonite suspension is obtained.

[0039] Comparative Example 2 The difference from Example 1 is that steps S1 and S2 are not carried out, and montmorillonite powder is directly used for step S3, and the remaining steps and raw material ratios are the same as those in Example 1.

[0040] Comparative Example 3 The difference from Example 1 is that step S3 is not carried out, and the montmorillonite fine powder after plasma treatment in step S2 is directly mixed with the suspending agent, sodium saccharin, glucose, gelatin and water in proportion, and step S4 is carried out, and the ratio of each raw material is the same as that in Example 1.

[0041] Experimental Example Taking the montmorillonite suspensions of Examples 1-5 and Comparative Examples 1-3 as the detection objects, the sedimentation ratio, viscosity and adsorption force of each sample were tested respectively according to the following methods, and the results are shown in Table 1.

[0042] 1. Sedimentation ratio Sample preparation: Take 50 ml of each test sample, shake vigorously for 1 min to mix evenly, and immediately transfer it to a 50 ml dry stoppered graduated cylinder, and the liquid level just reaches the 50 ml scale line.

[0043] Shaking and standing: Tighten the stopper of the graduated cylinder, shake vigorously for 1 min, and stand vertically for 3 h.

[0044] Reading and calculation: Record the initial liquid level height H0 and the height H1 of the sedimented suspension (accurate to 0.2 ml).

[0045] The sedimentation volume ratio is calculated according to the formula: sedimentation volume ratio = H1 / H0.

[0046] Each group of samples was tested 3 times, and the average value was taken as the final sedimentation ratio.

[0047] 2. Viscosity test The viscosity of each sample was tested using the rotational viscometer method (Brookfield type).

[0048] Pretreatment: Keep the suspension at a constant temperature of 25 ± 0.5 °C and stand to defoam.

[0049] Instrument setting: Select a suitable rotor and rotation speed (50 rpm), and preheat the viscometer.

[0050] Measurement: Inject the sample into the test cup and submerge the rotor to the marked line.

[0051] Start the instrument and record the viscosity value (unit: mPa·s) after the reading stabilizes.

[0052] Repeat each group of specimens 3 times and take the average value.

[0053] 3. Adsorption force test Calculate its adsorption capacity by the amount of strychnine sulfate adsorbed by montmorillonite.

[0054] Solution preparation: Gastric acid simulating solution (pH = 1.2), phosphate buffer solution (pH = 6.8). Strychnine sulfate solution: Accurately weigh about 2 g of strychnine sulfate, dissolve it in water and make up the volume to 100 ml.

[0055] Adsorption operation: Accurately weigh 0.5 g of montmorillonite suspension, place it in a stoppered conical flask, add 10 ml of phosphate buffer solution and 5 ml of gastric acid simulating solution, shake well; accurately add 10 ml of strychnine sulfate solution. Shake in a water bath at 37°C for 1 h, filter (discard the initial filtrate), and take the subsequent filtrate for standby.

[0056] Absorbance determination: Gradually dilute the subsequent filtrate with buffer solution to an appropriate concentration. Use the strychnine sulfate solution (20 μg / ml) diluted with buffer solution as the control. Measure the absorbance at a wavelength of 254 nm and calculate the adsorption force.

[0057] Table 1

[0058] It can be seen from Table 1 that for the montmorillonite suspensions prepared in Examples 1-5, their viscosity, adsorption force and sedimentation ratio are all relatively excellent, and their sedimentation ratio is close to 1, indicating that the montmorillonite suspensions in Examples 1-5 have good stability and the montmorillonite is evenly dispersed in the solvent. In Comparative Example 1, the montmorillonite powder was not refined, and the sedimentation ratio of the prepared montmorillonite suspension changed little, and the changes in viscosity and adsorption force were also small. In Comparative Example 3, the fine montmorillonite powder was not coated, and the binding ability of montmorillonite with the suspending agent was relatively poor, and the stability of the suspending agent was poor. Therefore, the montmorillonite suspension in Comparative Example 3 has poor stability and a small sedimentation ratio.

[0059] Randomly select 80 patients with acute diarrhea, aged 20-30 years old, without other diseases, and take the montmorillonite suspensions in Examples 1-5 and Comparative Examples 1-3 respectively. Statistically evaluate the patients' evaluations of the earthy feeling and gritty feeling of the montmorillonite suspension, and the results are shown in Table 2.

[0060] Table 2

[0061] It can be concluded from Table 2 that the montmorillonite suspensions of Examples 1-5, which are combined by refining montmorillonite powder and gelatin coating, can significantly reduce the earthy and gritty feeling of the montmorillonite suspensions through the synergistic effect of the two, and patients are more likely to accept them. In Comparative Example 1, no refining and coating treatment was performed. Although flavoring agents such as glucose and sodium saccharin were added to the montmorillonite suspension, most patients still had a sense of earth and grit; in Comparative Example 2, no refining treatment was performed. Although gelatin was used to coat the montmorillonite, a few people still felt a sense of earth and grit, and the mouthfeel was poor compared to the montmorillonite suspensions of Examples 1-5. In Comparative Example 3, only refining treatment was performed, which can reduce the grit feeling to a certain extent, but the shielding effect on the earthy feeling is poor.

[0062] In summary, the montmorillonite suspension provided in the embodiment of the present invention uses gelatin as a shell to coat the montmorillonite powder to reduce the earthy and gritty feeling of the oral montmorillonite suspension, and the gelatin on the surface of the coated montmorillonite powder works synergistically with the suspending agent to improve the stability of the montmorillonite suspension, and the sedimentation ratio of the montmorillonite suspension approaches 1.

[0063] The embodiments described above are part of the embodiments of the present invention, rather than all of the embodiments. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention claimed for protection, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

Claims

1. A montmorillonite suspension, characterized in that, Comprising the following raw materials by weight parts: Montmorillonite powder 1 - 2 parts, suspending agent 15 - 20 parts, gelatin 0.5 - 1 part, sodium saccharin 0.001 - 0.002 parts, glucose 0.01 - 0.02 parts, water 20 - 30 parts.

2. The montmorillonite suspension according to claim 1, characterized in that, The suspending agent is a mixture of xanthan gum, sodium carboxymethyl cellulose, and sodium alginate, and the mass ratio of the three is 1:(0.5 - 0.8):(0.05 - 0.1).

3. The montmorillonite suspension according to claim 2, wherein The mass ratio of xanthan gum, sodium carboxymethyl cellulose, and sodium alginate is 1:0.5:0.

05.

4. A method for preparing a montmorillonite suspension according to any one of claims 1-3, characterized in that, Comprising the following steps: S1, Add a dispersant to the montmorillonite powder, first perform high-speed shear dispersion treatment, then add water and perform ultrasonic treatment, let it stand, take the middle layer after stratification, dry and crush to obtain fine montmorillonite powder; S2, Use oxygen as the working gas to perform plasma treatment on the fine montmorillonite powder obtained in step S1; S3, Mix the fine montmorillonite powder treated in step S2 with water, disperse evenly by ultrasonic wave, heat up to 40 - 50 °C, adjust the pH value to 8.5, then dropwise add an aqueous gelatin solution with a pH of 4.0, stir evenly, cool down to 30 - 35 °C, refrigerate, and then perform spray drying to obtain composite particles; S4, Mix the composite particles, suspending agent, sodium saccharin, glucose, and water in proportion, disperse evenly by ultrasonic wave to obtain the montmorillonite suspension.

5. The preparation method of the montmorillonite suspension according to claim 4, wherein, In step S3, the mass fraction of the aqueous gelatin solution is 2 - 3%.

6. The preparation method of the montmorillonite suspension according to claim 4, characterized in that, In step S2, the power density of the plasma treatment is 50 - 100 W / L; the treatment time is 5 - 10 min.

7. The preparation method of the montmorillonite suspension according to claim 4, characterized in that, In step S4, the power density of the ultrasonic dispersion is 0.3 - 0.5 W / mL, the treatment time is 10 - 20 s, wherein, ultrasonic treatment is performed for 3 - 5 s, paused for 3 - 5 s, and repeated 3 - 5 times.

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