Preparation method and application of natural mild non-irritant soothing composition

Abstract

The invention relates to skin care products, in particular to a preparation method and application of a natural, mild and non-irritant soothing composition. The invention relates to a natural mild non-irritant soothing composition, which is prepared from the following components in parts by weight: 10 to 50 parts of polyhydric alcohol, 0.025 to 2.5 parts of kava pepper root extract, 0.1 to 10 parts of swertia bimaculata extract, 0.1 to 10 parts of licochalcone A, 0.2 to 2 parts of 1, 2-hexanediol and 0.2 to 2 parts of p-hydroxyacetophenone. The invention proves that the soothing composition composed of the kava pepper root extract, the swertia extract and the licochalcone A can quickly and effectively solve the technical problems in the prior art, and the soothing effect of the soothing composition is verified from three common skin sensitivity problems of stabbing pain, pruritus and redness.

Description

Technical Field

[0001] The present invention relates to skin care products, in particular to a preparation method and application of a natural, mild and non-irritating soothing composition. Background Art

[0002] As consumers become increasingly demanding of their skin, simple moisturizing and hydrating skincare products are no longer sufficient. Consumers are increasingly seeking high-performance skincare products, such as vitamin C for intense whitening, retinol for intense anti-aging, and salicylic acid for intense exfoliation and acne treatment. While these high-performance skincare products offer rapid and significant results, they can also be harmful to the skin. Intolerant skin or high concentrations of the active ingredients can lead to skin barrier damage, redness, stinging, itching, swelling, and other skin allergies. Furthermore, factors such as staying up late, stress, and poor diet contribute to poor skin condition in young people, exacerbating the problem of skin allergies caused by high-performance skincare products. Therefore, developing effective, soothing, gentle, and non-irritating skincare products suitable for consumers prone to allergies has become a pressing need. Summary of the Invention

[0003] In view of the deficiencies of the prior art, one of the objects of the present invention is to provide a natural, mild and non-irritating soothing composition, a second object of the present invention is to provide a method for preparing the composition, and a third object of the present invention is to provide the use of the composition in skin care products.

[0004] One of the objectives of the present invention is achieved through the following technical solutions:

[0005] A natural, mild, non-irritating soothing composition comprising the following components in parts by weight:

[0006] 10-50 parts of polyols, 0.025-2.5 parts of Kava kava root extract, 0.1-10 parts of Swertia japonica extract, 0.1-10 parts of licorice chalcone A (1% purity, the same below), 0.2-2 parts of 1,2-hexanediol and 0.2-2 parts of p-hydroxyacetophenone.

[0007] Furthermore, the polyol includes one, two or more of glycerol, butylene glycol, propylene glycol, dipropylene glycol, methyl propylene glycol, ethylhexyl glycerol, 1,2-pentanediol, 1,2-hexanediol and 1,3-propylene glycol.

[0008] The second object of the present invention is achieved through the following technical solutions:

[0009] A method for preparing a natural, mild, and non-irritating soothing composition comprises the following steps:

[0010] Step 1: weighing polyol, Kava kava root extract, Swertia japonica extract, licorice chalcone A, 1,2-hexanediol, p-hydroxyacetophenone and water according to the formula;

[0011] Step 2: Add polyol, 1,2-hexanediol, p-hydroxyacetophenone and water to an emulsifying pot, heat to 75-80°C, stir for 15-20 minutes, and then cool down after the raw materials are dissolved without particles;

[0012] Step 3: When the temperature drops to 40-45°C, add the Kava root extract, Swertia japonica extract, and Licorice Chalcone A, stir for 20-30 minutes, and continue to cool after stirring evenly;

[0013] Step 4: When the temperature drops to 35-38℃, take samples for inspection. If qualified, filter through a 400-mesh double-layer filter before discharging.

[0014] The third object of the present invention is achieved through the following technical solutions:

[0015] A natural, mild and non-irritating soothing composition is used in preparing a soothing essence.

[0016] Furthermore, the soothing essence comprises the following components in parts by mass:

[0017] 0.05 parts of disodium EDTA, 5 parts of glycerol, LECIGEL TM 0.5 parts of thickener, 0.05 parts of xanthan gum, 0.5 parts of M68, 3 parts of isononyl isononanoate, 2 parts of squalane, 2 parts of 6-viscosity silicone oil, 10 parts of soothing composition, 0.01 parts of fragrance, 0.5 parts of 1,2-hexanediol, 0.5 parts of p-hydroxyacetophenone and 3 parts of 1,3-propylene glycol.

[0018] Furthermore, the preparation method of the soothing essence comprises the following steps:

[0019] Step 1: Weigh disodium EDTA, glycerol, and LECIGEL according to the formula. TM Thickener, xanthan gum, M68, isononyl isononanoate, squalane, 6-viscosity silicone oil, soothing composition, fragrance, 1,2-hexanediol, parahydroxyacetophenone, 1,3-propylene glycol and water;

[0020] Among them, disodium EDTA, glycerin, LECIGEL TM Thickener, xanthan gum and water are the raw materials of phase A, M68, isononyl isononanoate, squalane and 6-viscosity silicone oil are the raw materials of phase B, soothing composition is the raw material of phase C, fragrance is the raw material of phase D, 1,2-hexanediol, p-hydroxyacetophenone and 1,3-propylene glycol are the raw materials of phase E;

[0021] Step 2: Add the raw materials of phase A into the emulsifier, heat to 75-80℃, and homogenize for 3-5 minutes until it is uniform and free of particles;

[0022] Step 3: Add the ingredients of phase B to the oil phase pot, heat to 75-80°C, stir evenly until there are no particles, and set aside;

[0023] Step 4: Pump the prepared oil phase pot raw materials into the emulsification pot, homogenize for 3-5 minutes, keep warm and stir for 15-20 minutes, and then start cooling;

[0024] Step 5: Heat the raw materials of phase E to 75-80°C, stir and dissolve until clear and free of particles, and set aside;

[0025] Step 6: When the emulsification pot is cooled to 40-45°C, add the Phase C raw materials, Phase D raw materials, and the prepared Phase E raw materials into the emulsification pot and stir for 15-20 minutes;

[0026] Step seven: After stirring evenly, take samples for inspection, and filter out the material after passing the inspection.

[0027] A natural, mild and non-irritating soothing composition is used in the preparation of soothing toner.

[0028] Furthermore, the soothing toner comprises the following components in parts by mass:

[0029] 0.05 parts of disodium EDTA, 5 parts of glycerin, 0.05 parts of polyacrylate crosspolymer-6, 2 parts of erythritol, 10 parts of soothing composition, 1 part of PEG / PPG-14 / 7 dimethyl ether, 0.01 parts of fragrance, 0.5 parts of 1,2-hexanediol, 0.5 parts of p-hydroxyacetophenone and 3 parts of 1,3-propylene glycol.

[0030] A natural, mild and non-irritating soothing composition is used in preparing a soothing essence lotion.

[0031] Furthermore, the soothing essence lotion comprises the following components in parts by mass:

[0032] 0.05 parts of disodium EDTA, 5 parts of glycerin, 0.15 parts of carbomer, 0.3 parts of parahydroxyacetophenone, 2 parts of 1,3-propylene glycol, 1 part of C62, 0.5 parts of Olivem 10000, 5 parts of caprylic / capric triglyceride, 2 parts of squalane, 1 part of diisostearyl malate, 0.5 parts of cetearyl alcohol, 2 parts of 100 viscosity silicone oil, 0.3 parts of 10% sodium hydroxide solution, 10 parts of soothing composition, 0.05 parts of ethylhexylglycerin, 0.5 parts of phenoxyethanol and 0.01 parts of fragrance.

[0033] The beneficial effects of the present invention are as follows: The present invention proves that the soothing composition composed of Kava kava root extract, Swertia japonica extract, and Licochalcone A can quickly and effectively solve the technical problems existing in the prior art, and verifies its soothing effect on three common skin sensitivity problems: stinging, itching, and redness:

[0034] 1) Kava root extract: When the skin is stimulated (such as capsaicin), TRPV1 receptors are activated, causing an influx of Ca2+ and K+, resulting in a burning and stinging sensation. Kava root extract contains various kavalactones, including capsaicin at a concentration of ≥6000 μg / ml. Kavalactones bind to lipid membranes and non-specifically modulate GABA (gamma-aminobutyric acid) receptors, opening Cl- channels and causing Cl- influx. This leads to neuronal hyperpolarization or depolarization, reducing TRPV1 overexpression, inhibiting cell excitation, and relieving peripheral pain.

[0035] 2) Swertia vulgaris extract: Swertia vulgaris extract mainly contains iridoid glycosides, of which swetiamarin is the most widely distributed and highest in content. Swertiamarin has anti-inflammatory and antibacterial effects, such as significantly alleviating histamine-induced skin itching and edema. The swetiamarin content in the swetiamarin extract is ≥5000 μg / ml;

[0036] 3) Licorice Chalcone A: UV rays induce skin cells to release inflammatory mediators and chemokines, such as kinins, iNOS, COX-2, IL1, IL-6, and TNF-a, leading to inflammation and increased vascular permeability. iNOS is a key mediator of inflammation and, through the production of nitric oxide, contributes to UVB radiation-induced erythema and vasodilation. Licorice Chalcone A can alleviate symptoms such as skin redness and vasodilation by inhibiting the expression of iNOS, COX-2, and IL-6.

[0037] The present invention utilizes a variety of bioactive substances contained in plant-derived complexes (whose pharmacological characteristics are reflected in the multi-pathway synergistic mechanism) to achieve steady-state optimization through a dual pathway of targeted regulation and overall regulatory effects. This systemic mode of action has more significant long-term benefits than single-target intervention. In addition, herbal raw materials with traditional medicinal and edible properties have obvious advantages over synthetic compounds in terms of biocompatibility and can greatly reduce the incidence of adverse reactions. Therefore, natural plant composite ingredients, with their unique advantages of being pure, safe, and effective, provide innovative solutions for sensitive skin management. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] Figure 1 is the skin hemoglobin content; Note: ** indicates a very significant difference compared with before use, P<0.010.

[0039] Figure 2 is the change value of skin hemoglobin content.

[0040] Figure 3 = (measured value after use - measured value before use) ÷ measured value before use × 100%. DETAILED DESCRIPTION

[0041] The following is further explained in conjunction with specific implementation methods:

[0042] Description of each embodiment recipe

[0043] Table 1 Soothing composition formula in each embodiment

[0044]

[0045]

[0046] Table 2 Soothing Essence Formula

[0047]

[0048] Table 3 Soothing Toner Formula

[0049]

[0050]

[0051] Table 4 Soothing Essence Milk Formula

[0052]

[0053]

[0054] Example 1

[0055] Prepare the soothing composition:

[0056] 1. Accurately weigh the various raw materials in the formula (Table 1 Example 1) and place them in clean and sterilized containers;

[0057] 2. Clean, disinfect, and dry the emulsifying pot. Add ingredients No. 1, 5, 6, and 7 in the recipe into the emulsifying pot. Heat to 75°C and stir for 15 minutes. Once the ingredients are dissolved and there are no particles, start cooling.

[0058] 3. When the temperature of the emulsifying pot drops to 40°C, add ingredients No. 2, 3, and 4, stir for 20 minutes, and continue to cool down after stirring evenly.

[0059] 4. When the temperature of the emulsifying pot drops to 35℃, take samples for inspection. After passing the inspection, filter the material with a 400-mesh double-layer filter.

[0060] To prepare the soothing serum:

[0061] 1. Accurately weigh the various raw materials in the formula (Table 2) and place them in clean and sterilized containers;

[0062] 2. Clean, disinfect and dry the emulsifying pot, add the raw materials of phase A into the emulsifying pot, heat it to 75℃, and start homogenization for 3 minutes until it is uniform and free of particles;

[0063] 3. Clean, disinfect and dry the oil phase pot, add the Phase B raw materials into the oil phase pot, heat to 75°C, stir evenly until there are no particles, and set aside;

[0064] 4. Pump the prepared oil phase pot raw materials into the emulsification pot, homogenize for 3 minutes, keep warm and stir for 15 minutes, then start cooling;

[0065] 5. Heat the raw materials of phase E to 75°C, stir and dissolve until clear and free of particles, and set aside;

[0066] 6. When the temperature of the emulsifying pot drops to 40°C, add the raw materials of phase C, phase D, and the prepared raw materials of group E into the emulsifying pot and stir for 15 minutes;

[0067] 7. After stirring evenly, take samples for inspection. After passing the inspection, filter and discharge the material.

[0068] Example 2

[0069] Prepare the soothing composition:

[0070] 1. Accurately weigh the various raw materials in the formula (Table 1 Example 2) and place them in clean and sterilized containers;

[0071] 2. Clean, disinfect, and dry the emulsifying pot. Add ingredients No. 1, 5, 6, and 7 in the recipe into the emulsifying pot. Heat to 77°C and stir for 17 minutes. Once the ingredients are dissolved and there are no particles, start cooling.

[0072] 3. When the temperature of the emulsifying pot drops to 42°C, add ingredients No. 2, 3, and 4, stir for 25 minutes, and continue to cool after stirring evenly.

[0073] 4. When the temperature of the emulsifying pot drops to 36℃, take samples for inspection. After passing the inspection, filter the material with a 400-mesh double-layer filter.

[0074] Prepare the Calming and Soothing Toner:

[0075] The soothing toner was prepared by weighing the raw materials according to the formula (Table 3) using conventional methods.

[0076] Example 3

[0077] Prepare the soothing composition:

[0078] 1. Accurately weigh the various raw materials in the formula and place them in clean and sterilized containers;

[0079] 2. Clean, disinfect, and dry the emulsifying pot. Add ingredients No. 1, 5, 6, and 7 in the recipe into the emulsifying pot. Heat to 80°C and stir for 20 minutes. Once the ingredients are dissolved and there are no particles, start cooling.

[0080] 3. When the temperature of the emulsifying pot drops to 45°C, add ingredients No. 2, 3, and 4, stir for 30 minutes, and continue to cool after stirring evenly.

[0081] 4. When the temperature of the emulsifying pot drops to 38℃, take samples for inspection. After passing the inspection, filter the material with a 400-mesh double-layer filter.

[0082] Prepare the soothing serum:

[0083] The soothing essence lotion was prepared by weighing the raw materials according to the formula (Table 4) using a conventional method.

[0084] Verification experiment

[0085] 1. Redness Reduction Test

[0086] 1. Test sample: Example 1

[0087] 2. Purpose of the test: To evaluate the immediate soothing and redness-reducing effect of the test product by testing the hemoglobin content in a group of subjects using the test product. A smaller measured value indicates a decrease in the hemoglobin content in the skin, and the skin becomes less red.

[0088] 3. Test subjects: 15 sensitive Asian women aged 20-55 years (lactic acid stimulation score > 3);

[0089] 4. Frequency of use: Use once

[0090] 5. Test cycle: before using the sample (T0), 15 minutes after using the sample (T1), 30 minutes after using the sample (T2), 1 hour after using the sample (T3)

[0091] 6. Test site: face

[0092] 7. Testing instrument: Courage+Khazaka skin melanin and hemoglobin measuring instrument MX18

[0093] 8. Judgment criteria:

[0094] If the statistical method significance level p<0.050, it indicates that there is a statistically significant difference between the subjects before and after using the sample; if the statistical method significance level p<0.010, it indicates that there is a statistically very significant difference between the subjects before and after using the sample; if the statistical method significance level p≥0.050, it indicates that there is no statistically significant difference between the subjects before and after using the sample.

[0095] 9. Test method: After cleansing, take an appropriate amount of this product and pat it evenly on the face, avoiding the skin around the eyes, and gently massage until absorbed.

[0096] 10. Test results:

[0097] See Figure 1-3 Compared with before using the sample:

[0098] 15 minutes after applying the sample, the hemoglobin content in the cheek test area was significantly reduced by 21.09%.

[0099] 30 minutes after using the sample, the hemoglobin content in the cheek test area was significantly reduced by 21.53%.

[0100] One hour after applying the sample, the hemoglobin content in the cheek test area was significantly reduced by 24.16%.

[0101] 11 Conclusion:

[0102] Compared with before using the sample, the skin hemoglobin content was significantly reduced 15 minutes after using the sample, 30 minutes after using the sample, and 1 hour after using the sample. The test results show that under this test condition, the test sample has a redness-reducing effect.

[0103] 2. Analgesia Test: Capsaicin Sting Test

[0104] 1. Test principle:

[0105] Capsaicin produces pain by acting on TRPV1 receptors. Activation of TRPV1 receptors by capsaicin triggers a massive influx of Ca2t. TRPV1 is widely distributed in neurons of the dorsal root ganglion, trigeminal ganglion, and vagus ganglion, transmitting nociceptive signals. Most small-diameter neurons are connected to thin, myelinated A8 fibers or unmyelinated C fibers, and are therefore believed to be closely involved in pain transmission. TRPV1 receptors can activate unmyelinated C sensory neurons, directly opening nonselective cation channels that trigger Ca2t influx and cellular depolarization, leading to neuronal excitation and pain transmission.

[0106] In this experiment, the subjects were stimulated with capsaicin and scored the pain caused by capsaicin to evaluate the pain relief effect of the soothing composition on stinging pain.

[0107] 2. Materials and Methods

[0108] Test sample: Example 1

[0109] Negative control: blank control

[0110] Subjects: 15 healthy adults aged 20-55 years

[0111] Frequency of use: Use once

[0112] Application area: inner forearm

[0113] Test process:

[0114] Capsaicin stimulation: Test on the inner arm. Apply 30 μL of 0.01% capsaicin solution to each area (apply to a 0.8 cm diameter mask sheet) and continue stimulating until the capsicum solution on the mask sheet is completely dry. Remove the mask sheet and sit quietly for about 20 minutes. Continue stimulating until a tingling sensation occurs.

[0115] Sample application: The sample application volume is 50 μL, single use, and applied evenly; the other side is left untreated and serves as the control group;

[0116] Data collection after sample use: 10 minutes, 20 minutes, 30 minutes, and 60 minutes after sample use, the stinging sensation at different time points was scored (see Table 5), and the soothing effect of the sample was evaluated based on the score;

[0117] 3. Judgment criteria

[0118] Table 5 Skin stinging reaction scoring standards

[0119] Level score Rating basis 0 none 1 Mild, occasionally felt 2 Moderate, with noticeable stinging, but tolerable 3 Severe, with very obvious stinging pain, unbearable

[0120] 4. Test results

[0121] Table 6 Summary of capsaicin sting test scores

[0122]

[0123] 5. Conclusion

[0124] As shown in Table 6, in the capsaicin stinging test, Example 1 had 2 cases and 1 case of mild stinging of 1 point at 10 minutes and 20 minutes respectively, and all cases were 0 points with no stinging after 30 minutes; while the control group had more cases of mild stinging of 1 point at 10 minutes and 20 minutes respectively, and 1 case of moderate stinging of 2 points. At 30 minutes, there were still 2 cases of mild stinging of 1 point, and it was not until 60 minutes that all cases were 0 points with no stinging. It can be concluded that Example 1 has a significant inhibitory effect on the pain caused by capsaicin, indicating that the product containing the soothing composition has a soothing effect on stinging.

[0125] 3. Anti-itch test: Histamine itch test

[0126] 1. Test principle:

[0127] When the skin is irritated, keratinocytes release inflammatory factors, which are transmitted to Langerhans cells, activating T and B cells. These factors produce 1gE, which binds to mast cells to produce histamine. Histamine is a mediator released by mast cells during allergic reactions. It stimulates the synthesis and secretion of proinflammatory cytokines and chemokines such as IL-1A, IL-1B, IL-6, IL-8, or RANTES in various cells and tissues, causing itching, capillary dilation and increased permeability, smooth muscle spasm, and increased secretory activity. Clinically, this can manifest as urticaria-like symptoms such as redness, itching, and blistering. Histamine also stimulates nerve endings in the skin, directly causing itching and the release of substance P (SP). This triggers mast cell degranulation and releases histamine, further causing itching. Furthermore, scratching caused by itching can lead to the release of inflammatory mediators, exacerbating the itching.

[0128] In this experiment, the sample was used after the itching model was induced by histamine stimulation, and the subjects scored the itching to evaluate the soothing and antipruritic effect of the composition.

[0129] 2. Materials and Methods

[0130] Test sample: Example 1

[0131] Negative control: blank control

[0132] Subjects: 15 healthy adults aged 20-55 years

[0133] Frequency of use: Use once

[0134] Application area: inner forearm

[0135] Test method:

[0136] Draw a frame on the inside of the arm and mark it. If two test areas are arranged on the same arm, the two frames need to be at least 5 cm apart (randomly mark them when the volunteer is testing, such as A, B, C), otherwise it will affect the results;

[0137] Pipette 30 μL of 1.6% histamine solution and spread it evenly with a fingertip or dropper tip. Sit quietly and observe.

[0138] When you feel itchy or blisters appear, start applying the sample, 50 μL per time, evenly. The other side will be left untreated as the control group.

[0139] The itching sensation at 10 min, 20 min, 30 min, and 60 min after the use of the samples was scored (Table 7), and the soothing and antipruritic effects of the samples were evaluated based on the scores.

[0140] 3. Judgment criteria

[0141] Table 7 Grading standards for skin pruritus reactions

[0142]

[0143] 4. Test results

[0144] Table 8 Summary of histamine itch test scoring results

[0145]

[0146] 5. Conclusion

[0147] As shown in Table 8, in the histamine-induced itch test, Example 1 only experienced a score of 1 for essentially no itch and a score of 2 for mild itch in the first 30 minutes of sample application, and after 60 minutes, the score was 1 for essentially no itch. In contrast, the control group experienced not only a score of 2 for mild itch in the first 30 minutes of sample application, but also two cases of moderate itch (3 points) and one case of severe itch (4 points) at 10 minutes. Furthermore, after 60 minutes, one case of mild itch (2 points) still had unrelieved symptoms. This indicates that Example 1 exhibits a significant inhibitory effect on histamine-induced itch, demonstrating that products containing this soothing composition have soothing and antipruritic effects.

[0148] 4. Mild and non-irritating test: Chicken embryo chorioallantoic membrane test

[0149] 1. Test principle

[0150] The chick chorioallantoic membrane test is an early in vitro method for evaluating eye irritation. The chorioallantoic membrane (CAM) is a respiratory membrane that surrounds the chick embryo. This test utilizes the intact, clear, and transparent vascular system of the chorioallantoic membrane in mid-stage incubation. A certain amount of the test substance is directly exposed to the chorioallantoic membrane. After a period of exposure, changes in toxic effect indicators (such as bleeding, coagulation, and vascular melting) are observed. These indicators reflect changes in the morphology, structure, color, and permeability of the blood vessels and vascular network, as well as phenomena such as chorioallantoic membrane protein denaturation and the degree of damage. These indicators are then combined to generate a score used to assess the eye irritation potential of the test substance.

[0151] 2. Instruments, equipment and reagents

[0152] Instruments and equipment:

[0153] M3LY630T stereo microscope; SPF chicken embryos; JM176 fully automatic incubator.

[0154] Reagents and consumables:

[0155] 0.9% normal saline; 0.1 mol / L sodium hydroxide solution.

[0156] Test substance:

[0157] Sample: original material of Example 1; negative control: 0.9% normal saline; positive control group: 0.1 mol / L sodium hydroxide solution.

[0158] 3. Test method:

[0159] Select SPF fertilized chicken embryos. When the chicken embryos are 9 days old, perform egg candling and discard the fertilized and inactive chicken embryos. Select chicken embryos with well-developed blood vessels and mark the position of the air chamber on the eggshell surface.

[0160] Carefully remove the eggshell and eggshell membrane using forceps, ensuring the exposed allantoic membrane is intact and undamaged. Apply the test substance to the CAM. After the exposure period, observe the degree of change in each toxic effect under a stereomicroscope and assign a score (ES).

[0161] 4. Judgment criteria:

[0162] Table 9 Irritation Classification

[0163] End point score Irritation classification ES≤4 Non-irritating 4<ES≤12 Mild irritation 12<ES<16 Moderate irritation ES≥16 Strong irritant / corrosive

[0164] If the reaction results of the negative and positive controls set in the test are within the classification range of non-irritation and strong irritation, respectively, the test results are considered acceptable. The negative control (0.9% saline) has an IS of 0.00, indicating that the sample is non-irritating and meets the criteria of a negative control sample. The positive control (0.1 mol / L sodium hydroxide solution) has an IS of 10-19, indicating that the sample is strongly irritating / corrosive and meets the criteria of a positive control sample. The irritation of the sample is determined based on the sample ES test results.

[0165] 5. Test results

[0166] Table 10 ES values and irritation classification

[0167]

[0168] 6. Conclusion

[0169] According to the laboratory method (XYJC-SOP-CE-015 Chicken Embryo Chorioallantoic Membrane Test Operation Guide), the irritation of the sample of Example 1 was tested. The test results showed that when the negative and positive controls of the test system met the reference standard (negative control IS=0.00, positive control IS=16.65), when the sample of Example 1 was the original, its ES=2.00, indicating that the sample of Example 1 was non-irritating and had a mild non-irritating effect.

[0170] The above embodiments and descriptions are only for explaining the principles and best embodiments of the present invention. Without departing from the spirit and scope of the present invention, the present invention may be subject to various changes and improvements, which shall fall within the scope of the invention to be protected.

Claims

1. A natural, mild and non-irritating soothing composition, characterized in that: The composition includes the following parts by weight: 10-50 parts of polyols, 0.025-2.5 parts of Kava Kava root extract, 0.1-10 parts of Swertia japonica extract, 0.1-10 parts of Licorice Chalcone A, 0.2-2 parts of 1,2-hexanediol and 0.2-2 parts of p-hydroxyacetophenone.

2. The soothing composition according to claim 1, characterized in that: The polyol includes one, two or more of glycerol, butylene glycol, propylene glycol, dipropylene glycol, methyl propylene glycol, ethylhexyl glycerol, 1,2-pentanediol, 1,2-hexanediol and 1,3-propylene glycol.

3. A method for preparing the soothing composition according to claim 1, comprising the following steps: Step 1: weighing polyol, Kava kava root extract, Swertia japonica extract, licorice chalcone A, 1,2-hexanediol, p-hydroxyacetophenone and water according to the formula; Step 2: Add polyol, 1,2-hexanediol, p-hydroxyacetophenone and water to an emulsifying pot, heat to 75-80°C, stir for 15-20 minutes, and then cool down after the raw materials are dissolved without particles; Step 3: When the temperature drops to 40-45°C, add the Kava root extract, Swertia japonica extract, and Licorice Chalcone A, stir for 20-30 minutes, and continue to cool after stirring evenly; Step 4: When the temperature drops to 35-38℃, take samples for inspection. If qualified, filter through a 400-mesh double-layer filter before discharging.

4. Use of the soothing composition according to claim 1 in preparing a soothing essence.

5. The use according to claim 4, characterized in that The soothing essence comprises the following components in parts by weight: 0.05 parts of disodium EDTA, 5 parts of glycerol, LECIGEL TM 0.5 parts of thickener, 0.05 parts of xanthan gum, 0.5 parts of M68, 3 parts of isononyl isononanoate, 2 parts of squalane, 2 parts of 6-viscosity silicone oil, 10 parts of soothing composition, 0.01 parts of fragrance, 0.5 parts of 1,2-hexanediol, 0.5 parts of p-hydroxyacetophenone and 3 parts of 1,3-propylene glycol.

6. The use according to claim 5, characterized in that The preparation method of the soothing essence comprises the following steps: Step 1: Weigh disodium EDTA, glycerol, and LECIGEL according to the formula. TM Thickener, xanthan gum, M68, isononyl isononanoate, squalane, 6-viscosity silicone oil, soothing composition, fragrance, 1,2-hexanediol, parahydroxyacetophenone, 1,3-propylene glycol and water; Among them, disodium EDTA, glycerin, LECIGEL TM Thickener, xanthan gum and water are the raw materials of phase A, M68, isononyl isononanoate, squalane and 6-viscosity silicone oil are the raw materials of phase B, soothing composition is the raw material of phase C, fragrance is the raw material of phase D, 1,2-hexanediol, p-hydroxyacetophenone and 1,3-propylene glycol are the raw materials of phase E; Step 2: Add the raw materials of phase A into the emulsifier, heat to 75-80℃, and homogenize for 3-5 minutes until it is uniform and free of particles; Step 3: Add the ingredients of phase B to the oil phase pot, heat to 75-80°C, stir evenly until there are no particles, and set aside; Step 4: Pump the prepared oil phase pot raw materials into the emulsification pot, homogenize for 3-5 minutes, keep warm and stir for 15-20 minutes, and then start cooling; Step 5: Heat the raw materials of phase E to 75-80°C, stir and dissolve until clear and free of particles, and set aside; Step 6: When the emulsification pot is cooled to 40-45°C, add the Phase C raw materials, Phase D raw materials, and the prepared Phase E raw materials into the emulsification pot and stir for 15-20 minutes; Step seven: After stirring evenly, take samples for inspection, and filter out the material after passing the inspection.

7. Use of the soothing composition according to claim 1 in preparing soothing toner.

8. The use according to claim 7, characterized in that The soothing toner comprises the following components in parts by mass: 0.05 parts of disodium EDTA, 5 parts of glycerin, 0.05 parts of polyacrylate crosspolymer-6, 2 parts of erythritol, 10 parts of soothing composition, 1 part of PEG / PPG-14 / 7 dimethyl ether, 0.01 parts of fragrance, 0.5 parts of 1,2-hexanediol, 0.5 parts of p-hydroxyacetophenone and 3 parts of 1,3-propylene glycol.

9. Use of the soothing composition according to claim 1 in preparing a soothing essence lotion.

10. The use according to claim 9, characterized in that The soothing essence lotion comprises the following components in parts by mass: 0.05 parts of disodium EDTA, 5 parts of glycerin, 0.15 parts of carbomer, 0.3 parts of hydroxyacetophenone, 2 parts of 1,3-propylene glycol, 1 part of C62, 0.5 parts of Olivem 1000, 5 parts of caprylic / capric triglyceride, 2 parts of squalane, 1 part of diisostearyl malate, 0.5 parts of cetearyl alcohol, 2 parts of 100 viscosity silicone oil, 0.3 parts of 10% sodium hydroxide solution, 10 parts of soothing composition, 0.05 parts of ethylhexylglycerin, 0.5 parts of phenoxyethanol and 0.01 parts of fragrance.

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