Composite dietary nutrition supplement composition and preparation method thereof

Abstract

The invention relates to the technical field of nutritional supplements, in particular to a composite dietary nutritional supplement composition and a preparation method thereof. The nutritional supplement composition comprises the following components in parts by weight: 20-40 parts of maltitol, 10-25 parts of collagen peptide, 3-8 parts of sodium hyaluronate, 1-5 parts of nicotinamide, 4-8 parts of vitamin B, 2-10 parts of vitamin C, 5-15 parts of compound amino acid powder, 0.5-3 parts of y-aminobutyric acid, 2-8 parts of spina date seeds, 1-5 parts of a grape skin extract, 10-30 parts of maltodextrin and 0.5-2 parts of a food additive. According to the invention, the compound dietary nutrition supplement composition is formed by compounding eleven nutrient substances, the components can mutually cooperate to achieve the effects of reducing blood sugar, resisting aging and improving immunity, and meanwhile, the dietary nutrition supplement composition has the characteristics of high nutritional value, small eating side effect, good use effect and the like; and the nutritional supplement use of people in the current fast-paced life can be met.

Description

Technical Field

[0001] The present invention relates to the technical field of nutritional supplements, and in particular to a composite dietary nutritional supplement composition and a preparation method thereof. Background Art

[0002] Nutritional supplements, also known as nutritional supplements, nutritional agents, and dietary supplements, are supplements used as an adjunct to diet to replenish the amino acids, trace elements, vitamins, and minerals needed by the human body. Nutritional supplements can be composed of amino acids, polyunsaturated fatty acids, minerals, and vitamins, or simply one or more vitamins. They can also be composed of one or more dietary ingredients. In addition to nutrients such as amino acids, vitamins, and minerals, they can also contain herbs or other plant ingredients, or concentrates, extracts, or combinations of these ingredients.

[0003] With the improvement of living standards, people are paying more and more attention to their health. Problems such as high blood sugar, aging and low immunity are plaguing many people. Although there are various products targeting single health problems on the market, such as blood sugar-lowering drugs, anti-aging skin care products and health products that enhance immunity, there are relatively few compound dietary nutritional supplements that have the multiple functions of lowering blood sugar, anti-aging and enhancing immunity. In addition, some existing products have problems such as single ingredients, insignificant effects and large side effects.

[0004] Therefore, it is of great practical significance to develop a safe, effective and complex dietary nutritional supplement composition that can simultaneously improve multiple health problems. Summary of the Invention

[0005] The purpose of the present invention is to solve the problems of the existing dietary nutritional supplement compositions, such as single ingredients, insignificant effects and large side effects, and to propose a composite dietary nutritional supplement composition and a preparation method thereof.

[0006] In order to achieve the above object, the present invention adopts the following technical solutions:

[0007] A composite dietary nutritional supplement composition comprises the following ingredients, measured by weight: 20-40 parts of maltitol, 10-25 parts of collagen peptide, 3-8 parts of sodium hyaluronate, 1-5 parts of niacinamide, 4-8 parts of vitamin B, 2-10 parts of vitamin C, 5-15 parts of composite amino acid powder, 0.5-3 parts of γ-aminobutyric acid, 2-8 parts of sour jujube kernel, 1-5 parts of grape skin extract, 10-30 parts of maltodextrin, and 0.5-2 parts of food additives.

[0008] As a further description of the above technical solution:

[0009] The food additive is magnesium stearate.

[0010] As a further description of the above technical solution:

[0011] The molecular weight of the collagen peptide is ≤2000Da.

[0012] As a further description of the above technical solution:

[0013] The resveratrol content in the grape skin extract is ≥50%.

[0014] A method for preparing a composite dietary nutritional supplement composition comprises the following steps:

[0015] Step 1: Raw material pretreatment: Use an ultrafine grinder to grind the jujube kernel to 200-300 mesh, use a vacuum low-temperature dryer to concentrate the grape skin extract to a solid content of 80-90%, and dry it at a low temperature of 40-50°C;

[0016] Step 2: Mixing: According to the precise formula, weigh maltitol, collagen peptide, sodium hyaluronate, niacinamide, vitamin B, vitamin C, compound amino acid powder, gamma-aminobutyric acid, pre-treated jujube kernel powder, grape skin extract and maltodextrin, and put these ingredients into a three-dimensional mixer for mixing;

[0017] Step 3: Granulation: Evenly spray an appropriate amount of 50-70% ethanol solution into the mixed material to form a soft material. When the soft material is in a state where it can be held in a hand and falls apart when pressed lightly, the soft material can be passed through an 18-22 mesh screen for granulation to obtain wet granules.

[0018] Step 4: Drying: Transfer the wet granules to a vacuum drying oven for drying. When the moisture content of the wet granules drops to 2-4%, proceed to the next step.

[0019] Step 5: Granulation: The dried granules are passed through a 16-20 mesh screen and granulated by a granulator to remove sticky particles and fine powder generated during the drying process.

[0020] Step 6: Tableting: Accurately weigh magnesium stearate according to the formula amount, add it to the granules after granulation, use a mixer to mix, so that the magnesium stearate is evenly coated on the surface of the granules, and then use a rotary tablet press to perform tableting operation, accurately control the tablet weight to 0.3-1.0 g / tablet, and the pressure to 5-8 kN, finally obtaining a tablet with a smooth appearance and appropriate hardness.

[0021] As a further description of the above technical solution:

[0022] In the step 2, the rotation speed of the three-dimensional mixer is set to 150-250 rpm, and the mixing time is set to 25-35 minutes.

[0023] As a further description of the above technical solution:

[0024] In step 4, the drying temperature of the vacuum drying oven is set to 55-65° C., and the vacuum degree is set to -0.08-0.06 MPa.

[0025] As a further description of the above technical solution:

[0026] In step 6, the mixer is set at a rotation speed of 80-120 rpm and a mixing time of 10-15 minutes.

[0027] In summary, due to the adoption of the above technical solution, the beneficial effects of the present invention are:

[0028] 1. In the present invention, maltitol is a low-calorie sweetener whose metabolism does not require the participation of insulin, will not cause a rapid rise in blood sugar, and can promote the growth of beneficial intestinal bacteria, help regulate intestinal microecology, and thus play a positive role in stabilizing blood sugar. At the same time, certain amino acids in the compound amino acid powder can participate in the synthesis and secretion regulation of insulin, which helps maintain normal blood sugar metabolism levels, and gamma-aminobutyric acid can improve insulin resistance by regulating the function of the nervous system, thereby lowering blood sugar levels.

[0029] 2. In the present invention, collagen peptides can replenish collagen lost in the skin, increase skin elasticity, and reduce the formation of wrinkles. Sodium hyaluronate has a strong moisturizing function, which can maintain the moisture of the skin, make the skin hydrated and smooth, and delay skin aging. Niacinamide can inhibit the production of melanin, improve skin color, and at the same time promote the metabolism of skin cells and enhance the barrier function of the skin. The antioxidant substances such as proanthocyanidins rich in grape skin extract can effectively scavenge free radicals in the body, reduce the damage to cells caused by oxidative stress, delay cell aging, and thus achieve an overall anti-aging effect.

[0030] 3. In the present invention, vitamin C has an antioxidant effect, can enhance the activity of immune cells, promote the formation of antibodies, and improve the body's immunity. Composite amino acid powder is the basic unit of protein. Adequate amino acid supply helps maintain the normal growth and function of immune cells and enhance the body's immune defense capabilities. The Chinese jujube seed extract has a calming and tranquilizing effect and can improve sleep quality. Good sleep is an important guarantee for improving immunity. At the same time, the various components work together to act on the body's immune system and enhance the body's resistance to pathogens. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1This is a process flow chart of a method for preparing a composite dietary nutritional supplement composition proposed by the present invention;

[0032] Figure 2 This is the blood sugar test diagram of the zebrafish blood sugar reduction project in the present invention;

[0033] Figure 3 This is the ROS detection diagram of the zebrafish anti-aging project in the present invention;

[0034] Figure 4 This is a diagram of neutrophil detection for the zebrafish immunity enhancement project in the present invention. DETAILED DESCRIPTION

[0035] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts shall fall within the scope of protection of the present invention.

[0036] See also Figure 1 The present invention provides a technical solution: a composite dietary nutritional supplement composition, wherein the ingredients of the nutritional supplement composition are as follows, by weight: 20-40 parts of maltitol, 10-25 parts of collagen peptide (molecular weight ≤ 2000Da), 3-8 parts of sodium hyaluronate, 1-5 parts of niacinamide, 4-8 parts of vitamin B (vitamin B1 and vitamin B2 mixed in a ratio of 1:1), 2-10 parts of vitamin C, 5-15 parts of composite amino acid powder, 0.5-3 parts of γ-aminobutyric acid, 2-8 parts of jujube kernel, 1-5 parts of grape skin extract (resveratrol content ≥ 50%), 10-30 parts of maltodextrin, and 0.5-2 parts of food additive (magnesium stearate).

[0037] For details, please refer to Figure 1 A method for preparing a composite dietary nutritional supplement composition comprises the following steps:

[0038] Step 1: Raw material pretreatment: Use an ultrafine grinder to grind the jujube kernel to 200-300 mesh. This process can greatly increase the specific surface area of the jujube kernel, which is conducive to the dissolution and absorption of the subsequent active ingredients. Use a vacuum low-temperature dryer to concentrate the grape skin extract to a solid content of 80-90%, and dry it at a low temperature of 40-50°C. This can maximize the retention of the bioactive ingredients in the grape skin extract and avoid the damage to their activity caused by high temperature.

[0039] Step 2: Mixing: According to the precise formula, weigh maltitol, collagen peptide, sodium hyaluronate, niacinamide, vitamin B1, vitamin B2, vitamin C, compound amino acid powder, γ-aminobutyric acid, pretreated jujube kernel powder, grape skin extract and maltodextrin, put these ingredients into a three-dimensional mixer for mixing, set the speed of the three-dimensional mixer to 150-250 rpm, and the mixing time to 25-35 minutes. The three-dimensional mixer can achieve full tumbling and mixing of the materials in three-dimensional space to ensure uniform distribution of the ingredients;

[0040] Step 3: Granulation: Evenly spray an appropriate amount of 50-70% ethanol solution into the mixed material to form a soft material. When the soft material is in a state where it can be held in a hand and falls apart when pressed lightly, the soft material can be passed through an 18-22 mesh screen for granulation to obtain wet granules.

[0041] Step 4: Drying: Transfer the wet granules to a vacuum drying oven for drying. Set the drying temperature of the vacuum drying oven to 55-65°C and the vacuum degree to -0.08-0.06MPa. When the moisture content of the wet granules drops to 2-4%, proceed to the next step.

[0042] Step 5: Granulation: The dried granules are passed through a 16-20 mesh screen and granulated by a granulator to remove sticky particles and fine powder generated during the drying process, ensuring the uniformity of the granules and providing good material conditions for the subsequent tableting process.

[0043] Step 6, tableting: accurately weigh magnesium stearate according to the formula amount, add it to the granules after granulation, use a mixer to mix, set the mixer speed to 80-120 rpm, set the mixing time to 10-15 minutes, so that the magnesium stearate is evenly coated on the surface of the granules to play a lubricating role, and then use a rotary tablet press to perform tableting operation, accurately control the tablet weight to 0.3-1.0 g / tablet, and the pressure to 5-8 kN, finally obtaining a tablet with a smooth appearance and appropriate hardness.

[0044] Example 1

[0045] 20 parts of maltitol, 10 parts of collagen, 3 parts of sodium hyaluronate, 1 part of niacinamide, 2 parts of vitamin B12, 2 parts of vitamin B2, 2 parts of vitamin C, 5 parts of compound amino acid powder, 0.5 parts of γ-aminobutyric acid, 2 parts of jujube seeds, 1 part of grape skin extract, 10 parts of maltodextrin and 0.5 parts of magnesium stearate are prepared into tablets according to the above preparation method, and the weight of the prepared tablets is controlled at 0.3 g / tablet.

[0046] Fifty volunteers with high blood sugar levels were selected and randomly divided into two groups, with 25 people in each group. The experimental group took the product prepared in this example three times a day, two capsules each time; the control group took a placebo. After taking it for three consecutive months, the blood sugar levels of the two groups of volunteers were tested. The results showed that both fasting blood sugar and postprandial blood sugar of the volunteers in the experimental group decreased significantly compared with the control group, and the difference was statistically significant (P < 0.05).

[0047] Thirty volunteers with signs of skin aging were randomly divided into two groups, 15 in each. The experimental group took the product prepared in this example three times daily, two capsules each time; the control group took a placebo. After six months of continuous use, the skin conditions of both groups were observed. The results showed that the experimental group showed significantly increased skin elasticity, fewer wrinkles, and improved skin radiance compared to the control group, demonstrating significant differences.

[0048] Forty volunteers with compromised immunity and a high risk of catching colds were randomly divided into two groups, each consisting of 20 participants. The experimental group took the product prepared in this example three times daily, two capsules each time; the control group took a placebo. After four months of continuous use, the number of colds reported by the volunteers in both groups was counted. The results showed that the experimental group experienced significantly fewer colds than the control group, demonstrating that this product effectively enhances immunity.

[0049] Example 2

[0050] 30 parts of maltitol, 20 parts of collagen, 6 parts of sodium hyaluronate, 3 parts of niacinamide, 3 parts of vitamin B1, 3 parts of vitamin B2, 6 parts of vitamin C, 10 parts of compound amino acid powder, 1.5 parts of γ-aminobutyric acid, 5 parts of jujube kernel, 3 parts of grape skin extract, 20 parts of maltodextrin and 1 part of food additive magnesium stearate are prepared into tablets according to the above preparation method, and the weight of the prepared tablets is controlled at 0.6 g / tablet.

[0051] The blood sugar, anti-aging and immunity effects were verified using similar experimental methods as in Example 1. The results also showed that the product prepared in this example had significant blood sugar lowering, anti-aging and immunity-enhancing effects.

[0052] Example 3

[0053] 40 parts of maltitol, 25 parts of collagen peptide, 8 parts of sodium hyaluronate, 5 parts of niacinamide, 4 parts of vitamin B1, 4 parts of vitamin B2, 10 parts of vitamin C, 15 parts of compound amino acid powder, 3 parts of γ-aminobutyric acid, 8 parts of jujube kernel, 5 parts of grape skin extract, 30 parts of maltodextrin and 2 parts of magnesium stearate are prepared into tablets according to the above preparation method, and the weight of the prepared tablets is controlled at 0.9 g / tablet.

[0054] The blood sugar, anti-aging and immunity effects were verified using an experimental method similar to that in Example 1, but the only difference was that the experimental group took the product prepared in this example three times a day, one capsule each time. The results also showed that the product prepared in this example had significant blood sugar lowering, anti-aging and immunity-enhancing effects.

[0055] In addition, in order to further verify whether the prepared composite dietary nutritional supplement composition has the effects of lowering blood sugar, anti-aging and improving immunity, three tablets prepared in Example 1 were selected, and the three tablets were sent for inspection separately. Feifan Standard Technical Services (Suzhou) Co., Ltd. was commissioned to conduct three tests: zebrafish blood sugar lowering project-blood sugar detection, zebrafish anti-aging project-ROS detection, and zebrafish immunity improving project-neutrophil detection.

[0056] Among them, the specific content of the zebrafish blood sugar lowering project - blood sugar testing is as follows:

[0057] Detection principle: Diabetes is a disease determined by genetics and triggered by environmental factors such as infection and obesity. Its basic pathophysiology is a metabolic disorder caused by absolute or relative insulin deficiency. The morphogenesis, basic cell structure, and arrangement of the zebrafish pancreas are similar to those of mammals. The appetite regulation (such as serotonin) and insulin regulation functions of zebrafish are similar to those of humans. The development and function of other organ systems of zebrafish involved in glucose homeostasis (including brain, liver, adipose cell tissue, and skeletal muscle) are also similar to those of mammals. Zebrafish show persistent hyperglycemia under sugar load. High-sugar and high-fat feed can induce hyperglycemia in zebrafish, simulating human type 2 diabetes. Use a blood glucose meter to test the blood glucose of high-sugar and high-fat zebrafish.

[0058] Experimental instruments and reagents: centrifuge (AG22331, Eppendorf Life Sciences), ultrasonic cell disruptor (UP-250, Ningbo Xinzhi Biotechnology Co., Ltd.), Roche Zhihang blood glucose meter (Roche, Germany), glucose (CAS: 50-99-7).

[0059] Detection system and sample size

[0060] Experimental system: Wild AB zebrafish

[0061] Zebrafish age: 1 day after fertilization

[0062] Sample size per group: 30 strips per well, 3 wells per group

[0063] Adult fish breeding and reproduction methods: in accordance with our company's standard breeding and reproduction methods

[0064] Applicability and limitations: Used for testing the hypoglycemic efficacy of health products and their raw materials. The sample must be soluble in water or prepared into a uniformly dispersed suspension in water.

[0065] Data processing method: SPSS26 software was used for analysis and GraphPad Prism8 was used for plotting. The data were expressed as mean ± standard deviation. SPSS software was used to test for normal distribution. If the data were normal, the significance was tested using T parametric test or analysis of variance (ANOVA). If the data were not normal, nonparametric test was used (P value < 0.05 indicated statistically significant difference).

[0066] Judgment basis: On the basis that the test meets the validity, the blood glucose value of the model control group is significantly increased compared with the blank control group (P<0.05), which means that the modeling is successful.

[0067] Compared with the model control group, the blood sugar level in the sample test group was significantly reduced (P<0.05), indicating that the sample has the effect of lowering blood sugar.

[0068] Specific test results such as Figure 2 As shown:

[0069] As can be seen from the above figure, the compound dietary nutritional supplement composition has the effect of lowering blood sugar. The report number is FTS202312844, and the official website of the test report is www.feifan-sz.cn.

[0070] Among them, the specific content of the zebrafish anti-aging project - ROS detection is as follows:

[0071] Principle of Assay: The level of ROS in the body is determined by the balance between the production and elimination of reactive oxygen species. When ROS levels rise, they deplete antioxidants. If antioxidant synthesis is slow and antioxidant enzymes are inadequate in clearing ROS, lipid and protein peroxidation can increase, leading to physiological phenomena associated with peroxidation, such as aging. If the test substance can accelerate antioxidant synthesis and enhance the activity of antioxidant enzymes, it can rapidly eliminate ROS, thereby reducing ROS-induced lipid and protein peroxidation and maintaining a healthy balance between the production and elimination of reactive oxygen species. Therefore, ROS is a more direct indicator of the balance between the production and elimination of reactive oxygen species in the body. Reduction in ROS levels in zebrafish after treatment with the test substance can also directly reflect the anti-aging potential of the test substance.

[0072] Experimental instruments and reagents: Stereo fluorescence microscope (SZX7, Olympus, Japan), ROS detection kit (Nanjing Jiancheng Bioengineering Institute).

[0073] Detection system and sample size

[0074] Experimental system: Wild AB zebrafish

[0075] Zebrafish age: 3 days after fertilization

[0076] Sample size per group: 30 strips per well, 1 well per group

[0077] Adult fish breeding and reproduction methods: in accordance with our company's standard breeding and reproduction methods

[0078] Applicability and limitations: Used for testing the anti-aging efficacy of health products and their raw materials. The sample must be soluble in water or prepared into a uniformly dispersed suspension in water.

[0079] Data processing method: SPSS26 software was used for analysis, and GraphPad Prism8 was used for drawing. The data statistics were expressed as mean ± standard deviation. SPSS software was used to perform normal distribution test. If the data were in accordance with normal distribution, T parametric test or analysis of variance (ANOVA) was used for significance. If the data were not in accordance with normal distribution, nonparametric test was used (P value < 0.05 indicated statistically significant difference).

[0080] Judgment basis: Compared with the blank control group, the fluorescence intensity of the sample test group was significantly reduced (P<0.05), indicating that the sample has anti-aging effect.

[0081] Specific test results such as Figure 3 As shown:

[0082] Figure legend: *: P < 0.05, **: P < 0.01, ***: P < 0.001. The more *, the smaller the P value, the more significant the difference.

[0083] As can be seen from the above figure, the compound dietary nutritional supplement composition has anti-aging effects. The report number is FTS202312845, and the official website of the test report is www.feifan-sz.cn.

[0084] Among them, the specific content of the zebrafish immunity improvement project - neutrophil detection is as follows:

[0085] Assay Principle: Zebrafish, a small tropical freshwater fish native to South Asia, are widely used as a vertebrate laboratory animal worldwide due to their ease of care, strong reproductive capacity, rapid development, and transparent, easily observable fertilized eggs. As a representative of lower vertebrates, zebrafish share 87% genetic homology with humans and are increasingly used in diverse fields, including disease model development, gene function assessment, drug screening, toxicity testing, and environmental health risk assessment. Zebrafish experiments have also contributed significantly to the development of traditional Chinese medicine, natural medicines, health foods, and functional foods. Zebrafish are immunocompromised by the administration of water-soluble chloramphenicol. High doses of chloramphenicol significantly suppress the immune system, leading to a decrease in platelet, red blood cell, and white blood cell counts (neutrophils, macrophages, T cells, etc.) and anemia, ultimately leading to immunosuppression. The cellular composition of the human and zebrafish immune systems is highly similar. Furthermore, zebrafish are the smallest of all animals currently possessing both specific and nonspecific immunity, making them suitable for high-throughput evaluation of immune-modulating effects. Using transgenic neutrophil green fluorescent zebrafish, a reduction in the number of neutrophils in immunocompromised zebrafish can be observed under a fluorescence microscope.

[0086] Detection system and sample size

[0087] Experimental system: Wild AB zebrafish

[0088] Zebrafish age: 3 days after fertilization

[0089] Sample size per group: 30 strips per well, 1 well per group

[0090] Adult fish breeding and reproduction methods: in accordance with our company's standard breeding and reproduction methods

[0091] Testing Procedure: We divided the zebrafish into three groups: a blank control group, a model control group, and a group receiving an immunomodulator. The normal control group received no chloramphenicol, while the model control group and the immunomodulator group received an equal amount of chloramphenicol. After treatment, changes in neutrophil counts were measured in each group.

[0092] Experimental instruments and reagents:

[0093] Fluorescence microscope (SZX7, Olympus, Japan), chloramphenicol (CAS: 56-75-7), and amine hydrochloride (CAS: 6078-17-7).

[0094] Applicability and limitations: Used for testing the efficacy of health products and their raw materials in improving immunity. The sample must be soluble in water or prepared into a uniformly dispersed suspension in water.

[0095] Data processing method: SPSS26 software was used for analysis, and GraphPad Prism8 was used for drawing. The data statistics were expressed as mean ± standard deviation. The experimental results were tested for normal distribution using SPSS software. If the data were in accordance with the normal distribution, the significance was tested using T parametric test or analysis of variance (ANOVA). If the data were not in accordance with the normal distribution, non-parametric test was used (the result P value <0.05 indicated statistically significant difference).

[0096] Judgment Basis: Based on the validity of the test, the neutrophil count in the model control group was significantly reduced compared to the blank control group (P<0.05), indicating successful modeling. The neutrophil count in the sample test group was significantly increased compared to the model control group (P<0.05), indicating that the sample has the effect of improving immunity.

[0097] Specific test results such as Figure 4 As shown:

[0098] Figure legend: *: P < 0.05, **: P < 0.01, ***: P < 0.001. The more *, the smaller the P value, the more significant the difference.

[0099] As can be seen from the above figure, the compound dietary nutritional supplement composition has the effect of improving immunity. The report number is FTS202312846, and the official website of the test report is www.feifan-sz.cn.

[0100] The above description is only a preferred specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any technician familiar with the technical field, within the technical scope disclosed by the present invention, who makes equivalent replacements or changes based on the technical solution and inventive concept of the present invention, should be covered by the scope of protection of the present invention.

Claims

1. A composite dietary nutritional supplement composition, characterized in that: The nutritional supplement composition comprises the following ingredients, calculated by weight: 20-40 parts of maltitol, 10-25 parts of collagen peptide, 3-8 parts of sodium hyaluronate, 1-5 parts of niacinamide, 4-8 parts of vitamin B, 2-10 parts of vitamin C, 5-15 parts of complex amino acid powder, 0.5-3 parts of γ-aminobutyric acid, 2-8 parts of jujube kernel, 1-5 parts of grape skin extract, 10-30 parts of maltodextrin, and 0.5-2 parts of food additives.

2. A composite dietary nutritional supplement composition according to claim 1, characterized in that: The food additive is magnesium stearate.

3. The composite dietary nutritional supplement composition according to claim 1, characterized in that: The molecular weight of the collagen peptide is ≤2000Da.

4. The composite dietary nutritional supplement composition according to claim 1, characterized in that: The resveratrol content in the grape skin extract is ≥50%.

5. The method for preparing a composite dietary nutritional supplement composition according to claim 1, characterized in that: The following steps are involved: Step 1: Raw material pretreatment: Use an ultrafine grinder to grind the jujube kernel to 200-300 mesh, use a vacuum low-temperature dryer to concentrate the grape skin extract to a solid content of 80-90%, and dry it at a low temperature of 40-50°C; Step 2: Mixing: According to the precise formula, weigh maltitol, collagen peptide, sodium hyaluronate, niacinamide, vitamin B, vitamin C, compound amino acid powder, gamma-aminobutyric acid, pre-treated jujube kernel powder, grape skin extract and maltodextrin, and put these ingredients into a three-dimensional mixer for mixing; Step 3: Granulation: Evenly spray an appropriate amount of 50-70% ethanol solution onto the mixed material to form a soft material. When the soft material is in a state where it can be held in a hand and falls apart when pressed lightly, it can be granulated through an 18-22 mesh screen to obtain wet granules. Step 4: Drying: Transfer the wet granules to a vacuum drying oven for drying. When the moisture content of the wet granules drops to 2-4%, proceed to the next step. Step 5: Granulation: The dried granules are passed through a 16-20 mesh screen and granulated by a granulator to remove sticky particles and fine powder generated during the drying process. Step 6: Tableting: Magnesium stearate is accurately weighed according to the formula amount and added to the granules after granulation. The mixture is mixed using a mixer so that the magnesium stearate is evenly coated on the surface of the granules. The tablets are then compressed using a rotary tablet press. The tablet weight is precisely controlled to be 0.3-1.0 g / tablet and the pressure is 5-8 kN. Finally, tablets with a smooth appearance and appropriate hardness are obtained.

6. The method for preparing a composite dietary nutritional supplement composition according to claim 5, characterized in that: In the step 2, the rotation speed of the three-dimensional mixer is set to 150-250 rpm, and the mixing time is set to 25-35 minutes.

7. The method for preparing a composite dietary nutritional supplement composition according to claim 5, characterized in that: In step 4, the drying temperature of the vacuum drying oven is set to 55-65° C., and the vacuum degree is set to -0.08-0.06 MPa.

8. The method for preparing a composite dietary nutritional supplement composition according to claim 5, characterized in that: In step 6, the mixer is set at a rotation speed of 80-120 rpm and a mixing time of 10-15 minutes.

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