Skin care composition based on compound natural components of convalescent villous tomentosa and preparation method of skin care composition

Abstract

The invention relates to a skincare composition and microemulsion based on compound natural components of convalescent tomentosa and a preparation method of the skincare composition and the microemulsion. The skincare composition comprises the following extracts in parts by weight: 0.01-10 parts of a convalescent tomentosa extract, 1-6 parts of a calendula extract, 0.5-3 parts of a fucus extract and 0.2-2 parts of a myrrh resin extract. According to the scheme, firstly, through component optimization, a convalescent tomentosa extract is used as a main material, a calendula extract, a fucus extract and a myrrh resin extract are used as auxiliary materials, a composite plant synergistic matrix is constructed, and red skin relieving and rapid itching relieving are achieved through multi-target regulation and control; meanwhile, the technical improvement of an extraction method is combined, effective components of all the raw materials can be comprehensively extracted, the synergistic effect is achieved, and then preparation optimization is combined, so that application of the composition is facilitated.

Description

Technical Field

[0001] The present invention relates to the field of cosmetics, in particular to a skin care composition based on a combination of natural ingredients of a healing velvet flower and a preparation method thereof. Background Art

[0002] Many people today suffer from irregular lifestyles, exposure to external stimuli such as sunlight, and improper use of skincare products, which can lead to thinning of the stratum corneum and dilation of capillaries, resulting in skin problems such as redness, itching, and even pain. While there are a wide variety of cosmetics on the market designed to soothe these redness, itching, and pain, most suffer from limited efficacy, lack significant results, or contain irritating ingredients. Some products only temporarily improve the appearance through physical masking, failing to address the root cause of the redness. Furthermore, some products claiming therapeutic effects may contain hormones or other harmful ingredients, further damaging the skin and leading to more serious skin problems.

[0003] The current raw material cosmetic technology for soothing skin redness, itching and pain also has significant defects: (1) The quality of the finished product is unstable. For example, the patent text CN106333909 A "A lotion for reducing facial redness and repairing skin and its preparation method" mainly uses plant extracts such as Atractylodes macrocephala, Coix seed, and Rosemary, but the active ingredients are easily degraded by light and temperature, resulting in poor product stability; (2) The active ingredients are single. For example, the patent text CN106539202 A "Application of acetyl hexapeptide-8 in anti-redness cosmetics" reduces inflammatory response by inhibiting the activity of matrix metalloproteinases (MMPs), but is highly pH sensitive (activity decreases by 50% when pH>6) and does not solve the problem of vascular elasticity.

[0004] Therefore, it is necessary to develop natural, multi-channel compositions that can relieve skin redness, itching and pain, and consumers in the market are more inclined to use such products. Summary of the Invention

[0005] In response to the deficiencies in the above-mentioned prior art, the present invention provides a skin care composition and microemulsion based on a combination of natural ingredients of the healing velvet flower. The composition and microemulsion can be better applied to cosmetics with different dosage forms and different functions, and have good compatibility and stability.

[0006] The specific technical solutions of the present invention are as follows:

[0007] A skin care composition based on a compound of natural ingredients of hyssopus var. amara comprises the following extracts in parts by weight: 0.01-10 parts of hyssopus var. amara extract; 1-6 parts of calendula officinalis extract; 0.5-3 parts of fucus vesiculosus extract; and 0.2-2 parts of myrrh resin extract.

[0008] Anthyllis vulneraria extract is known to soothe skin redness, primarily due to its rich active ingredients and unique mechanism of action (such as verbascosides, luteolin, quercetin, and sterols). Modern pharmacological research has confirmed its ability to precisely target inflammatory transcription factors such as NF-κB, inhibit the expression of pro-inflammatory cytokines such as IL-6, and alleviate vascular inflammation. Furthermore, the potent antioxidant capacity of polyphenols can scavenge free radicals such as superoxide anions, protect vascular endothelial cells, reduce oxidative stress damage to blood vessels, and reduce the occurrence of red blood streaks. Furthermore, its sterol components can help repair damaged stratum corneum, strengthen the skin barrier, and reduce the impact of external stimuli on blood vessels, thus preventing the occurrence of red blood streaks at the root.

[0009] Calendula extract contains active ingredients such as calendula glycoside, which can repair the stratum corneum barrier and promote epidermal cell regeneration.

[0010] Fucoxanthin contained in Fucus vesiculosus extract can resist oxidative stress and inhibit apoptosis of vascular endothelial cells.

[0011] Myrrh resin extract contains bisabolene, which can promote local blood circulation and inhibit the synthesis of inflammatory mediators.

[0012] The composition of the present invention is mainly composed of the extract of the healing velvet flower, and is supplemented by the extract of the calendula flower, the extract of the fucus vesiculosus, and the extract of the myrrh resin. The synergistic effect can be achieved by regulating multiple targets to relieve skin redness.

[0013] Preferably, the extract of the skin care composition further comprises: at least one of kelp digitata extract, licorice extract, and wheat extract, wherein by weight, the amount of kelp digitata extract is 0.01-5 parts; the amount of licorice extract is 0.5-3 parts; and the amount of wheat extract is 0.2-2 parts.

[0014] Laminaria japonica extract contains fucoidan, which moisturizes and locks in moisture, regulates endothelial cell function, and improves microcirculation. Licorice extract, containing glycyrrhizic acid, inhibits skin inflammation, reducing redness and discomfort. Wheat extract, rich in wheat protein, strengthens capillary wall elasticity and reduces vascular fragility. The addition of these extracts further reduces redness.

[0015] Preferably, the extract of the skin care composition is prepared by the following method, which comprises the steps of:

[0016] S1. Prepare the raw materials for each extract: by weight, 0.01-10 parts of hyssop flower powder, 1-6 parts of calendula powder, 0.5-3 parts of fucus powder, and 0.2-2 parts of myrrh resin powder, and mix them evenly;

[0017] S2. Mix the powder of S1 and soak it in 20-30% ethanol solution for 18 hours;

[0018] S3, adding the mixture obtained in S2 into an extraction kettle, and introducing CO2 into the extraction kettle for extraction;

[0019] S4. The CO2 fluid containing the volatile components of the plant flowing out of the extraction kettle is introduced into a separation kettle for decompression separation to obtain an extract. The extract in the separation kettle is poured out and the insoluble matter is filtered to obtain the plant extract.

[0020] Supercritical CO2 extraction captures fat-soluble and moderately polar components, achieving full coverage of the plant's active ingredients and enhancing the extract's efficacy. Extraction can be performed using a mixture of ingredients or individually. Preferably, the ingredients are extracted together to maximize synergistic effects.

[0021] Preferably, the skin care composition further comprises Laminaria japonica extract, Licorice extract and Wheat extract.

[0022] In a preferred embodiment of the present invention, the raw materials of the skin care composition are mixed in a dry weight ratio of 4:6:3:0.2:1:1:0.5 for extraction: Calendula officinalis: Laminaria japonica: Fucus vesiculosus: Licorice: Wheat: Myrrh.

[0023] Preferably, in step S1, the raw materials of the hyssop flower extract, calendula flower extract, liquorice extract, and wheat extract are dried at 40° C. to a moisture content of ≤8% and then crushed to 60 mesh to avoid high temperature destruction of flavonoid components.

[0024] Preferably, in step S1, the raw materials of Laminaria japonica extract and Fucus vesiculosus extract are first washed with fresh water to remove salt, vacuum dried at 50° C., and then crushed to 40 meshes, so as to retain more polysaccharide viscous substances.

[0025] Preferably, in step S1, the raw material of the myrrh extract is prepared by pre-cooling myrrh resin at -20°C for 2 hours, then crushing it, and passing it through an 80-mesh sieve to avoid resin adhesion and fully crushing it.

[0026] Preferably, in step S3, the extraction pressure is 35 MPa, the extraction temperature is 45° C., the flow rate of CO 2 is 25 L / h, and the extraction time is 30-50 min.

[0027] The present invention also provides a microemulsion comprising the above skin care composition.

[0028] Preferably, the microemulsion comprises the following components in weight percentage:

[0029]

[0030] The present invention also provides a method for preparing the microemulsion, comprising the following steps:

[0031] S1. Preparation of aqueous phase system: dissolving the skin care composition and moisturizer in water, stirring at 50°C to obtain an aqueous phase;

[0032] S2, oil phase emulsification: heat the oil and emulsifier to 70°C to dissolve and obtain the oil phase;

[0033] S3. Emulsification process: slowly add the oil phase into the water phase, homogenize for 5 minutes at a speed of 3500 r / min, cool to 40°C, then add the preservative to obtain a microemulsion.

[0034] Preferably, the moisturizing agent of the microemulsion comprises at least one of the following:

[0035] Glycerin, Butylene Glycol, Sodium Hyaluronate, Beta-Glucan, Propylene Glycol, Dipropylene Glycol, Trehalose.

[0036] Preferably, the oil of the microemulsion comprises at least one of the following:

[0037] Squalane, shea butter, coconut oil, 15# white oil, macadamia nut oil.

[0038] Preferably, the emulsifier of the microemulsion includes at least one of the following: cetearyl alcohol, glyceryl stearate, polysorbate 80, hydrogenated lecithin, and soy lecithin.

[0039] Preferably, the preservative of the microemulsion includes at least one of the following: p-hydroxyacetophenone, methylparaben, sodium benzoate, 1,2-hexanediol, and phenoxyethanol.

[0040] The beneficial effects of the present invention are:

[0041] The present invention first constructs a "complex plant synergistic matrix" through ingredient optimization, with the healing velvet flower extract as the main ingredient, and calendula flower extract, fucus vesiculosus extract, and myrrh resin extract as auxiliary ingredients, which work synergistically to relieve skin redness through multi-target regulation.

[0042] Combined with technical improvements in extraction methods, the effective ingredients of each raw material can be fully extracted, exerting a synergistic effect. This, combined with formulation optimization, facilitates the application of the composition. Compared with existing soothing raw materials in facial cosmetics, this invention achieves a breakthrough improvement through ingredient innovation, technical synergy, and formulation optimization. DETAILED DESCRIPTION

[0043] The present invention is further described below with reference to specific examples, which, however, are not intended to limit the present invention in any way. Unless otherwise specified, the reagents, methods, and equipment used in the present invention are conventional reagents, methods, and equipment in the art.

[0044] Unless otherwise specified, the reagents and materials used in the following examples are all commercially available products.

[0045] Example 1

[0046] A skin care composition based on the healing velvet flower compounded with natural ingredients is prepared by the following method:

[0047] Step 1: Raw material pretreatment

[0048] For the pretreatment of the raw materials of velvet flower, marigold, liquorice and wheat: dry them at 40℃ until the moisture content is ≤8%, and grind them into 60 mesh;

[0049] For the pretreatment of Laminaria japonica and Fucus vesiculosus raw materials: rinse with fresh water to remove salt, vacuum dry at 50℃ and crush to 40 mesh;

[0050] Pretreatment of myrrh resin raw materials: pre-cool at -20℃ for 2 hours, then crush and pass through 80 mesh sieve;

[0051] After pretreatment, the raw materials were mixed according to the ratio (see Table 1) and extracted.

[0052] Step 2: Preparation of extract

[0053] S1. Prepare the raw materials of each extract: 4 parts of hyssop flower powder, 6 parts of calendula powder, 3 parts of fucus powder, and 0.2 parts of myrrh resin powder (by weight), and mix them evenly;

[0054] S2. Soak the mixed powder in 20-30% ethanol solution for 18 hours;

[0055] S3, adding the obtained mixture to an extraction kettle, introducing CO2 into the extraction kettle for extraction, the extraction pressure is 35MPa, the extraction temperature is 45°C, the flow rate of CO2 is 25L / h, and the extraction time is 30-50min;

[0056] S4. The carbon dioxide fluid containing the volatile components of the plant flowing out of the extraction kettle is introduced into a separation kettle for decompression separation to obtain an extract; the insoluble matter is poured out and filtered to obtain a skin care composition.

[0057] Example 2

[0058] A skin care composition based on a combination of natural ingredients from the hyacinth flower is prepared in the same manner as in Example 1, except for the different components and proportions. The components of Example 2 are: 0.01 parts of the hyacinth flower powder; 3 parts of calendula flower powder; 2 parts of fucus vesiculosus powder; 1 part of myrrh resin powder; and 0.2 parts of kelp (by weight).

[0059] Example 3

[0060] A skin care composition based on a combination of natural ingredients from the hyacinth flower is prepared in the same manner as in Example 1, except for the different components and proportions. The ingredients in Example 3 are: 10 parts of the hyacinth flower powder; 1 part of the calendula flower powder; 0.5 parts of the fucus vesiculosus powder; 2 parts of the myrrh resin powder; 2.5 parts of the liquorice root; and 0.1 parts of the wheat (by weight).

[0061] Example 4

[0062] A microemulsion of a skin care composition based on a combination of natural ingredients of the healing velvet flower is prepared by preparing the skin care composition of Example 1 into a microemulsion. The specific ingredients are shown in Table 1. The microemulsion is prepared by the following method:

[0063] S1. Preparation of aqueous phase system: dissolving the skin care composition of Example 1 and glycerin in water, stirring at 50° C. to obtain an aqueous phase;

[0064] S2. Oil phase emulsification: heat cetearyl alcohol and squalane to 70°C to dissolve and obtain an oil phase;

[0065] S3, emulsification process: slowly add the oil phase of S2 into the water phase of S1, homogenize (speed 3500r / min) for 5min, cool to 40℃, add p-hydroxyacetophenone, stir evenly to obtain a microemulsion.

[0066] Example 5

[0067] A skin care composition microemulsion based on the healing velvet flower compounded with natural ingredients, the preparation method is the same as that of Example 4, except that the components and proportions are different, see Table 1 for details.

[0068] Example 6

[0069] A skin care composition microemulsion based on the healing velvet flower compounded with natural ingredients, the preparation method is the same as that of Example 4, except that the components and proportions are different, see Table 1 for details.

[0070] Comparative Example 1-2

[0071] Compared with Example 1, Comparative Example 1 uses kelp instead of the healing velvet flower, and Comparative Example 2 uses licorice instead of the healing velvet flower. The specific preparation method is the same as that of Example 1. The raw material ratio of the composition is shown in Table 1.

[0072] Comparative Examples 3-4

[0073] Comparative Examples 3-4 were prepared using the same method as Example 4, differing in the components and proportions. The ingredients in Comparative Example 3 were: 13.2 parts of the skin care composition of Example 1; 10 parts of glycerin; 2 parts of cetearyl alcohol; 3 parts of squalane; and 1 part of parahydroxyacetophenone. The ingredients in Comparative Example 4 were: 13.2 parts of the skin care composition of Example 1; 8 parts of glycerin; 7 parts of cetearyl alcohol; 6 parts of squalane; and 0.8 parts of parahydroxyacetophenone.

[0074] Table 1. Ingredient ratios of Examples and Comparative Examples

[0075]

[0076] Facial soothing test

[0077] Parameters: area ratio of red blood streaks, burning / pain sensation.

[0078] Equipment: VISIA-CR Facial Imaging Booth Brand: canfield

[0079] Skin Tester MPA580 Brand: CK

[0080] Sample preparation: 11 facial creams were prepared. Facial cream A was the basic formula (as shown in Table 2). The remaining facial creams were prepared by adding the compositions or microemulsions of the examples or comparative examples to Facial Cream A. Details are shown in Table 3.

[0081] Table 2. Cream A formula

[0082]

[0083] Table 3. Cream formula details

[0084]

[0085]

[0086] Testing process: 110 women aged 25-55 with facial redness were randomly divided into 11 groups. Each cream was applied twice daily for 28 days, with parameters measured every 7 days. The average value of each parameter was calculated for each group, and the soothing effect was evaluated based on the changes in the parameters.

[0087] Table 4. Facial soothing test data

[0088]

[0089]

[0090] Test results: Table 4 is the facial soothing test data, from which we can see that from 0 days to 28 days, the facial redness area of the volunteers using Cream A did not change significantly, and the burning / pain sensation did not decrease significantly, indicating that Cream A cannot soothe reddened skin and quickly relieve itching. However, the facial redness area of the volunteers using Creams 1-10 all decreased to varying degrees, the average burning / pain sensation decreased significantly, and the volunteer satisfaction increased significantly. Among them, Cream 1 containing 5% of Example 1 had the most significant effect. In terms of overall soothing efficacy, Cream 1 is better than Cream 7 and Cream 8, indicating that the extract of the healing velvet flower has an irreplaceable effect on the overall efficacy. This shows that adding a skin care composition containing the present patent invention has the efficacy of soothing reddened skin and quickly relieving itching and analgesia.

[0091] The technical features of the above-described embodiments can be combined in any combination. To simplify the description, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification. It should be pointed out that for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, and these all fall within the scope of protection of the present invention. Therefore, the scope of protection of the patent of this invention shall be based on the attached claims.

Claims

1. A skin care composition based on the healing velvet flower compounded with natural ingredients, characterized in that: The extract comprises the following parts by weight: 0.01-10 parts of Healing Velvet Flower Extract; 1-6 parts of calendula extract; 0.5-3 parts of Fucus vesiculosus extract; Myrrh resin extract 0.2-2 parts.

2. The skin care composition according to claim 1, characterized in that The extract further comprises: at least one of digitate kelp extract, liquorice extract and wheat extract, wherein the amount of digitate kelp extract is 0.01-5 parts; the amount of liquorice extract is 0.5-3 parts; the amount of wheat extract is 0.2-2 parts.

3. The skin care composition according to claim 1 or 2, characterized in that The extract is prepared by the following method, which comprises the following steps: S1. Prepare the raw materials of each extract: 0.01-10 parts of hyssop flower powder, 1-6 parts of calendula powder, 0.5-3 parts of fucus powder, and 0.2-2 parts of myrrh resin powder, and mix them evenly; S2. Mix the powder of S1 and soak it in 20-30% ethanol solution for 18 hours; S3, adding the mixture obtained in S2 into an extraction kettle, and introducing CO2 into the extraction kettle for extraction; S4. The CO2 fluid containing the volatile components of the plant flowing out of the extraction kettle is introduced into a separation axe for decompression separation to obtain an extract. The extract in the separation kettle is poured out and the insoluble matter is filtered to obtain the plant extract.

4. The skin care composition according to claim 3, characterized in that In step S1, the raw materials of the hyssopus odoratus extract, the calendula officinalis extract, the licorice extract, and the wheat extract are obtained by drying the hyssopus odoratus extract, the calendula officinalis extract, the licorice extract, and the wheat extract at a low temperature of 40° C. to a moisture content of ≤8%, and then grinding the extract into 60 mesh; The raw materials of Laminaria japonica extract and Fucus vesiculosus extract are obtained by washing with fresh water to remove salt, vacuum drying at 50°C and then crushing to 40 mesh; The raw material of the myrrh extract is prepared by precooling myrrh resin at -20°C for 2 hours, then grinding the resin and passing the mixture through an 80-mesh sieve.

5. The skin care composition according to claim 3, characterized in that In step S3, the extraction pressure is 35 MPa, the extraction temperature is 45° C., the flow rate of CO 2 is 25 L / h, and the extraction time is 30-50 min.

6. A microemulsion, characterized in that A skin care composition according to any one of claims 1 to 5, wherein the microemulsion comprises the following components in parts by weight:

7. A method for preparing the microemulsion according to claim 6, characterized in that: The steps include: S1. Preparation of aqueous phase system: dissolving the skin care composition and moisturizer in water, stirring at 50°C to obtain an aqueous phase; S2, oil phase emulsification: heat the oil and emulsifier to 70°C to dissolve and obtain the oil phase; S3. Emulsification process: slowly add the oil phase into the water phase, homogenize for 5 minutes at a speed of 3500 r / min, cool to 40°C, then add the preservative to obtain a microemulsion.

8. The microemulsion according to claim 6, characterized in that The moisturizing agent includes at least one of the following: glycerin, butylene glycol, sodium hyaluronate, β-glucan, propylene glycol, dipropylene glycol, and trehalose.

9. The microemulsion according to claim 6, characterized in that The oil comprises at least one of the following: squalane, shea butter, coconut oil, 15# white oil, and macadamia nut oil.

10. The microemulsion according to claim 6, characterized in that The emulsifier includes at least one of the following: cetearyl alcohol, glyceryl stearate, polysorbate-80, hydrogenated lecithin, and soy lecithin.

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