Composition containing cycloastragenol and oligopeptide and application of composition in anti-aging skin care product
Through the microbial fermentation method combined with the combined fermentation of Bacillus licheniformis and Aspergillus niger, the production process of astragalus cycloalis and oligopeptides is simplified, the problems of production complexity and high cost are solved, and the application of high permeability and high bioavailability of skin care products is achieved.
Patent Information
- Application Number
- CN202510551703.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-04-29
- Publication Date
- 2025-08-22
AI Technical Summary
In the prior art, the production of cycloalis astragalus is complex and costly, and it is difficult to effectively integrate the production process of oligopeptides and cycloalis astragalus, resulting in limited application in skin care products.
By using microbial fermentation method, the combination of Bacillus licheniformis and Aspergillus niger was prepared by combining the alkaline and acidic environment, the composition containing oligopeptides and cyclic astragalus alcohol was simplified to simplify the production steps and improve the permeability and bioavailability of the product.
It has achieved an efficient combination of oligopeptide and cycloalis, improved skin permeability and cell activity, reduced production costs, and facilitated large-scale production and application in anti-aging skin care products.
Smart Images
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Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of skin care products, and in particular to a composition containing cycloastragenol and oligopeptides and application thereof in anti-aging skin care products. Background Art
[0002] As a classification of peptides, oligopeptides generally have a molecular weight range below 1000 Daltons. They are also called small peptides, oligopeptides, oligopeptides, or small molecule active peptides. They are generally composed of 2-10 amino acids. Due to their excellent antioxidant properties, they can scavenge free radicals, reduce oxidative damage, and have the effect of delaying cell aging. Moreover, due to their small molecular weight and high permeability, they can be directly absorbed and utilized in the human body. They are extremely important functional ingredients added to skin care products.
[0003] At the same time, skin aging is essentially a natural degeneration process caused by the decline in the function of skin tissue cells. Skin cells are constantly metabolizing and dividing, and as the cell telomeres continue to shorten, irreversible aging will eventually occur. Therefore, increasing the activity of skin cells themselves, improving the skin's metabolic capacity, and delaying the shortening of skin cell telomeres are fundamental countermeasures to delay skin aging. Cycloastragenol belongs to the triterpenoid saponin class of compounds. Studies have shown that cycloastragenol is the only telomerase activator discovered so far. By increasing telomerase and thus delaying telomere shortening, cycloastragenol is believed to have anti-aging effects. However, cycloastragenol is almost non-existent in nature. It is mainly obtained by hydrolysis of astragalus extract. The entire production process is relatively complicated, which is not conducive to overall cost control. Summary of the Invention
[0004] The purpose of the present invention is to provide a composition containing cycloastragenol and oligopeptides. By introducing microbial fermentation, the entire production process of oligopeptides and cycloastragenol is directly integrated, thereby reducing production costs. The obtained product has good permeability, can activate cell activity, has excellent bioavailability, and has great prospects for application in anti-aging skin care products.
[0005] To achieve the above-mentioned purpose, the technical solution adopted by the present invention is: a composition containing cycloastragenol and oligopeptides; prepared by the following method:
[0006] A1. Prepare the stock solution: Mix animal collagen powder and deionized water in a mass ratio of 3-8:100 to form a collagen solution. Sterilize and set aside.
[0007] A2. First fermentation: Prepare spores at a concentration of 1-5×10 61-2% collagen solution of total weight was weighed out, and the Bacillus licheniformis suspension was inoculated into the weighed collagen solution at a volume ratio of Bacillus licheniformis suspension: collagen solution = 3-5:100. The fermentation was continued to obtain a primary fermentation broth with a bacterial concentration of 3-6×10 8 pcs / ml;
[0008] The primary fermentation broth is inoculated into the remaining collagen solution, the pH value is adjusted to 9.5 with sodium hydroxide solution, and the fermentation is continued with stirring for 24-36 hours to obtain the collagen fermentation broth; the collagen fermentation broth is sent to a centrifuge and centrifuged at 8000 rpm for 10 minutes. The supernatant after centrifugation is filtered through a 100 μm microporous membrane and then through an ultrafiltration membrane to obtain a collagen fermentation filtrate, wherein the molecular weight cut-off of the ultrafiltration membrane is less than 1000 Da;
[0009] A3. Oligopeptide encapsulation: Hydrogenated lecithin liposomes are added to the collagen fermentation filtrate at a ratio of 80-100 g / L, heated to 80-90°C in an ultrasonic homogenizer for homogenization for 30 minutes, and cooled to room temperature for later use. Hydrogenated lecithin liposomes are prepared by mixing and heating sterol compounds and liquid oils, then adding hydrogenated lecithin, a stabilizer, a pH adjuster, and deionized water, mixing, homogenizing, ultrasonicating, and cooling to obtain hydrogenated lecithin liposomes.
[0010] A4. Secondary fermentation: Adjust the pH to 5.5 with hydrochloric acid to obtain acidic protein fermentation liquid; add astragalus extract to the homogenized collagen fermentation filtrate at a ratio of 200 g / L, and adjust the spore concentration to 1-5×10 5 A suspension of Aspergillus niger spores (1000 spores / ml) is added to an acidic protein fermentation broth at a volume ratio of 5-8:100, and cultured on a constant temperature shaker at 30-35°C and 200-250 rpm for 4-6 days to obtain a mixed fermentation broth for later use; the mass concentration of the oligopeptide in the mixed fermentation broth is greater than 10‰, and the mass concentration of cycloastragenol is greater than 5%.
[0011] A5. Secondary filtration: After sterilizing the mixed fermentation broth, filter it through a 100 μm microporous membrane and then an ultrafiltration membrane with a molecular weight cutoff of less than 1000 Da to obtain the target composition.
[0012] Preferably, in step A1, the animal collagen powder is fish scale protein powder or pig skin protein powder with a purity of more than 90%.
[0013] Preferably, the target composition is used in anti-aging skin care products.
[0014] Preferably, the target composition is vacuum freeze-dried to obtain a lyophilized powder dosage form.
[0015] Preferably, the anti-aging skin care product comprising the target composition comprises the following raw materials in parts by weight:
[0016]
[0017] Preferably, it also includes 0.1 parts of Scutellaria baicalensis extract and 0.1 parts of Stephania tetrandra extract.
[0018] Preferably, the whitening agent comprises one or more of the following components: undecylenoylphenylalanine, raspberry ketone glucoside, 4-butylresorcinol, 5-octanoylsalicylic acid, tetrahydrocurcumin.
[0019] Preferably, the emulsifier includes one or more of the following components: glyceryl stearate, glyceryl polyether-26,
[0020] Preferably, the thickener comprises one or more of the following components: carrageenan, xanthan gum, carbomer, distearate, hydroxypropyl starch phosphate.
[0021] Undecylenoylphenylalanine (whitening agent), raspberry ketone glucoside (whitening and anti-aging), 4-butylresorcinol (melanin inhibition), 5-octanoylsalicylic acid (whitening, anti-aging), tetrahydrocurcumin (whitening, antioxidant)
[0022] The beneficial effects of the present invention are concentrated in:
[0023] 1. The target product is rich in oligopeptides and cycloastragenol, and has the characteristics of both. It has good skin permeability and high human absorption rate. It can effectively activate the activity of skin cells and can be widely promoted and used in anti-aging skin care products.
[0024] 2. The use of microbial fermentation simplifies the overall production process. The initial alkaline fermentation effectively ensures the fermentation conversion efficiency of Bacillus licheniformis in producing oligopeptide products in the substrate, while the secondary acidic fermentation fully maximizes the fermentation conversion efficiency of Aspergillus niger in producing cycloastragenol in the substrate. The combination of the two ensures efficient production of the target fermentation product while integrating the entire production process of oligopeptides and cycloastragenol. This eliminates the need for complex intermediate steps, is easy to control, facilitates large-scale production, and reduces costs.
[0025] 3. After the first fermentation is completed, the oligopeptide molecules are encapsulated and aggregated in micro-liposomes dispersed in hydrogenated lecithin liposomes to prevent the acidic environment during the second fermentation from damaging the oligopeptide molecules and causing denaturation. As the second fermentation proceeds, the hydrogenated lecithin liposomes gradually degrade and release the oligopeptide molecules, effectively ensuring the activity of the oligopeptide molecules. DETAILED DESCRIPTION
[0026] The present invention provides a composition containing both oligopeptides and cycloastragenol. It can be sold directly as a lyophilized powder or added to skin care products as an anti-aging ingredient. It combines the properties of both, with good skin permeability and high human absorption rate, effectively activating skin cell activity, and is widely applicable in anti-aging skin care products.
[0027] The effects of the present invention will be further described below by way of examples, in which the key distinguishing parameters in each example are highlighted by bold and underline.
[0028] Example 1
[0029] A composition containing cycloastragenol and oligopeptides; prepared by the following method:
[0030] A1. Preparation of stock solution: weigh 300g Fish scale collagen powder, 10kg Deionized water; mix the fish scale collagen powder with deionized water to form a collagen solution, sterilize it and set aside;
[0031] A2. First fermentation: Prepare spore concentration not less than 1×10 6 10 / ml of Bacillus licheniformis suspension was weighed, and 3 ml of collagen solution was inoculated into the weighed collagen solution. The fermentation was continued to obtain a primary fermentation liquid. During the fermentation process, samples were taken for testing. When the bacterial concentration in the primary fermentation liquid reached 3-6×10 8 / ml; the primary fermentation liquid was inoculated into the remaining collagen solution, the pH value was adjusted to 9.5 with sodium hydroxide solution, and the fermentation was continued with stirring for 24 hours to obtain collagen fermentation liquid; the collagen fermentation liquid was sent to a centrifuge and centrifuged at a speed of 8000 rpm for 10 minutes. The supernatant after centrifugation was filtered through a 100um microporous membrane and an ultrafiltration membrane in sequence to obtain a collagen fermentation filtrate. The molecular weight cutoff of the ultrafiltration membrane was below 1000Da; the oligopeptide content in the filtrate was detected. 14.43‰ .
[0032] A3. Oligopeptide encapsulation: according to 80g / L Add hydrogenated lecithin liposomes to the collagen fermentation filtrate in a ratio of , heat to 80-90°C in an ultrasonic homogenizer for 30 minutes, and cool to room temperature for later use;
[0033] A4. Secondary fermentation: Adjust the pH to 5.5 with 18% hydrochloric acid to obtain acidic protein fermentation broth; add astragalus extract (the concentration of astragaloside IV in the astragalus extract is not less than 90%) to the homogenized collagen fermentation filtrate at a ratio of 200 g / L, and adjust the spore concentration to ≈5×10 5A suspension of Aspergillus niger spores of 1000 spores / ml was added to the acidic protein fermentation broth at a volume ratio of 5:100, and cultured on a constant temperature shaker at 30-35°C and 200-250 rpm for 4 days to obtain a mixed fermentation broth for later use; the concentrations of oligopeptides and cycloastragenol in the mixed fermentation broth were detected, and the mass concentration of oligopeptides was 12.74‰ The mass concentration of cycloastragenol is 8.62％ ;
[0034] A5. Secondary filtration: After sterilizing the mixed fermentation broth, filter it through a 100 μm microporous membrane and then an ultrafiltration membrane with a molecular weight cutoff of less than 1000 Da to obtain the target composition.
[0035] Example 2
[0036] A composition containing cycloastragenol and oligopeptides; prepared by the following method:
[0037] A1. Preparation of stock solution: weigh 500g Pigskin collagen powder, 10kg Deionized water; mixing the pigskin collagen powder with deionized water to form a collagen solution, which is sterilized and then set aside;
[0038] A2. First fermentation: Prepare spore concentration not less than 1×10 6 10 ml of Bacillus licheniformis suspension was prepared, and a collagen solution with a total weight of 2% was weighed. 10 ml of the Bacillus licheniformis suspension was inoculated into the weighed collagen solution and fermentation was continued to obtain a primary fermentation liquid. During the fermentation process, samples were taken for testing. When the bacterial concentration in the primary fermentation liquid reached 3-6×10 8 / ml; the primary fermentation liquid was inoculated into the remaining collagen solution, the pH value was adjusted to 9.5 with sodium hydroxide solution, and the fermentation was continued with stirring for 36 hours to obtain collagen fermentation liquid; the collagen fermentation liquid was sent to a centrifuge and centrifuged at a speed of 8000 rpm for 10 minutes. The supernatant after centrifugation was filtered through a 100um microporous membrane and an ultrafiltration membrane in sequence to obtain a collagen fermentation filtrate. The molecular weight cutoff of the ultrafiltration membrane was below 1000Da; the oligopeptide content in the filtrate was detected. 25.45‰ .
[0039] A3. Oligopeptide encapsulation: according to 100g / L Add hydrogenated lecithin liposomes to the collagen fermentation filtrate in a ratio of , heat to 80-90°C in an ultrasonic homogenizer for 30 minutes, and cool to room temperature for later use;
[0040] A4. Secondary fermentation: Adjust the pH to 5.5 with 18% hydrochloric acid to obtain acidic protein fermentation broth; add astragalus extract (the concentration of astragaloside IV in the astragalus extract is not less than 90%) to the homogenized collagen fermentation filtrate at a ratio of 200 g / L, and adjust the spore concentration to ≈5×10 5 A suspension of Aspergillus niger spores of 1000 spores / ml was added to the acidic protein fermentation broth at a volume ratio of 5:100, and cultured on a constant temperature shaker at 30-35°C and 200-250 rpm for 6 days to obtain a mixed fermentation broth for later use; the concentrations of oligopeptides and cycloastragenol in the mixed fermentation broth were detected, and the mass concentration of oligopeptides was 20.58‰ The mass concentration of cycloastragenol is 9.54 %;
[0041] A5. Secondary filtration: After sterilizing the mixed fermentation broth, filter it through a 100 μm microporous membrane and then an ultrafiltration membrane with a molecular weight cutoff of less than 1000 Da to obtain the target composition.
[0042] Example 3
[0043] A composition containing cycloastragenol and oligopeptides; prepared by the following method:
[0044] A1. Preparation of stock solution: weigh 800g Pigskin collagen powder, 10kg Deionized water; mixing the pigskin collagen powder with deionized water to form a collagen solution, which is sterilized and then set aside;
[0045] A2. First fermentation: Prepare spore concentration not less than 1×10 6 10 ml of Bacillus licheniformis suspension was prepared, and a collagen solution with a total weight of 2% was weighed. 10 ml of the Bacillus licheniformis suspension was inoculated into the weighed collagen solution and fermentation was continued to obtain a primary fermentation liquid. During the fermentation process, samples were taken for testing. When the bacterial concentration in the primary fermentation liquid reached 3-6×10 8 / ml; the primary fermentation liquid was inoculated into the remaining collagen solution, the pH value was adjusted to 9.5 with sodium hydroxide solution, and the fermentation was continued with stirring for 36 hours to obtain collagen fermentation liquid; the collagen fermentation liquid was sent to a centrifuge and centrifuged at a speed of 8000 rpm for 10 minutes. The supernatant after centrifugation was filtered through a 100um microporous membrane and an ultrafiltration membrane in sequence to obtain a collagen fermentation filtrate. The molecular weight cutoff of the ultrafiltration membrane was below 1000Da; the oligopeptide content in the filtrate was detected. 37.54‰ .
[0046] A3. Oligopeptide encapsulation: according to 100g / LAdd hydrogenated lecithin liposomes to the collagen fermentation filtrate in a ratio of , heat to 80-90°C in an ultrasonic homogenizer for 30 minutes, and cool to room temperature for later use;
[0047] A4. Secondary fermentation: Adjust the pH to 5.5 with 18% hydrochloric acid to obtain acidic protein fermentation broth; add astragalus extract (the concentration of astragaloside IV in the astragalus extract is not less than 90%) to the homogenized collagen fermentation filtrate at a ratio of 200 g / L, and adjust the spore concentration to ≈5×10 5 A suspension of Aspergillus niger spores of 1000 spores / ml was added to the acidic protein fermentation broth at a volume ratio of 5:100, and cultured on a constant temperature shaker at 30-35°C and 200-250 rpm for 4 days to obtain a mixed fermentation broth for later use; the concentrations of oligopeptides and cycloastragenol in the mixed fermentation broth were detected, and the mass concentration of oligopeptides was 32.87‰ The mass concentration of cycloastragenol is 8.48 %;
[0048] A5. Secondary filtration: After sterilizing the mixed fermentation broth, filter it through a 100 μm microporous membrane and then an ultrafiltration membrane with a molecular weight cutoff of less than 1000 Da to obtain the target composition.
[0049] Comparative Example 1
[0050] The same method as in Example 1 was used for preparation, except that during the first fermentation, the pH value was not adjusted by sodium hydroxide;
[0051] The oligopeptide concentration measured after the first fermentation was 8.75‰ After the second fermentation, the oligopeptide concentration was 7.96‰ , the content of cycloastragenol is 8.95％ ;
[0052] The oligopeptide concentration was significantly lower than that in Example 1. It can be seen that in an alkaline environment of pH 9.5, Bacillus licheniformis has very obvious fermentation activity, which can greatly improve the yield of oligopeptides.
[0053] Comparative Example 2
[0054] The same method as in Example 1 was used for preparation, except that the pH value was not adjusted by hydrochloric acid during the secondary fermentation.
[0055] After the first fermentation, the oligopeptide content was 13.98‰ After the second fermentation, the oligopeptide concentration was 12.37‰ , the content of cycloastragenol is 3.35％ ;
[0056] The concentration of cycloastragenol was significantly lower than that in Example 1. It is not difficult to see that under acidic conditions of pH 5.5, Aspergillus niger has very significant fermentation activity, but when the acid-base environment changes, its fermentation activity is significantly reduced, resulting in a large decline in the yield of cycloastragenol.
[0057] Comparative Example 3
[0058] The same method as in Example 3 was used for preparation, but the oligopeptide was not encapsulated in hydrogenated lecithin liposomes.
[0059] After the first fermentation, the oligopeptide concentration was 36.84‰ After the second fermentation, the oligopeptide concentration was 18.68‰ , the concentration of cycloastragenol is 9.04％ ;
[0060] After the second fermentation, the concentration of oligopeptides decreased significantly due to the acidic environment. However, if the acidity is not adjusted, the subsequent yield of cycloastragenol will be greatly reduced. After analysis, the preliminary conclusion is that the change in the properties of oligopeptides in the acidic environment may be affected by the following factors, resulting in a decrease in the overall yield after the second fermentation:
[0061] 1. Amino acid composition: Different amino acids have different side chains, which may be protonated in an acidic environment. For example, amino acids with a carboxyl group (-COOH) (such as aspartic acid and glutamic acid) are more likely to accept protons in an acidic environment, thereby affecting the overall charge distribution and conformation of the oligopeptide.
[0062] 2. Destruction of hydrogen bonds: Acidic environment may destroy hydrogen bonds within or between oligopeptides, resulting in changes in their secondary structures (such as α-helix or β-sheet).
[0063] 3. Hydrophobic interactions: In an acidic environment, hydrophobic interactions may be enhanced or weakened, depending on the specific amino acid sequence of the oligopeptide and its distribution in the solution.
[0064] 4. Solubility changes: Acidic environment may affect the solubility of oligopeptides, causing them to precipitate or aggregate.
[0065] On the basis of the known properties of oligopeptides and cycloastragenol, the concentration of oligopeptides and cycloastragenol in the target composition directly determines the performance of the target composition in anti-aging and enhancing skin cell activity to a certain extent. The target composition is prepared by the method described in the present invention, and the collagen solution is directly used as the overall fermentation substrate. Through secondary fermentation, the first alkaline fermentation can effectively ensure the fermentation conversion efficiency of Bacillus licheniformis in producing oligopeptide products in the substrate, and the secondary acidic fermentation can give full play to the fermentation conversion efficiency of Aspergillus niger in producing cycloastragenol in the substrate. The two are combined with each other, while ensuring the effective output of the fermentation target product, the entire production process of oligopeptides and cycloastragenol is integrated, without the need for complicated intermediate steps, easy to control, convenient for large-scale production, and reducing costs.
[0066] Application Example 1
[0067] The composition prepared by the present invention can be directly sold as a cosmetic product. To ensure its storage activity, a better approach may be to vacuum freeze-dry the target composition to obtain a lyophilized powder dosage form, which is then used in combination with other solvents.
[0068] Application Example 2
[0069] Alternatively, the composition of the present invention can also be used as an additive and added as a raw material to a cosmetic formula to achieve better compounding and enhance the overall performance of the product. Taking the anti-aging skin care essence lotion as an example, it includes the following raw materials in parts by weight: target composition: 1-2 parts, glycerin: 4-10 parts, Bletilla striata extract: 1-2 parts, emulsifier: 10-15 parts, thickener: 2-4 parts, whitening agent 1-2 parts, water: 85-90 parts; it may also include other anti-aging and antioxidant ingredients, such as: 0.1 part of Scutellaria baicalensis extract and 0.1 part of Stephania tetrandra extract.
[0070] The whitening agent may be one or more of the following: undecylenyl phenylalanine, raspberry ketone glucoside, 4-butylresorcinol, 5-octanoylsalicylic acid, and tetrahydrocurcumin. The emulsifier may be one or more of the following: glyceryl stearate and glycereth-26. The thickener may be one or more of the following: carrageenan, xanthan gum, carbomer, distearate, and hydroxypropyl starch phosphate.
[0071] Of course, in addition to the above application examples, the composition of the present invention can also be compounded in various skin care and anti-aging products such as various lotions, creams, essences, facial masks, toners, etc. The above application examples do not limit the scope of application of the present invention.
Claims
1. A composition containing cycloastragenol and oligopeptides; characterized in that, Prepared by the following method: A1. Prepare the stock solution: Mix animal collagen powder and deionized water in a mass ratio of 3-8:100 to form a collagen solution. Sterilize and set aside. A2. First fermentation: Prepare spores at a concentration of 1-5×10 6 1-2% collagen solution of total weight was weighed out, and the Bacillus licheniformis suspension was inoculated into the weighed collagen solution at a volume ratio of Bacillus licheniformis suspension: collagen solution = 3-5:
100. The fermentation was continued to obtain a primary fermentation broth with a bacterial concentration of 3-6×10 8 pcs / ml; The primary fermentation broth is inoculated into the remaining collagen solution, the pH value is adjusted to 9.5 with sodium hydroxide solution, and the fermentation is continued with stirring for 24-36 hours to obtain the collagen fermentation broth; the collagen fermentation broth is sent to a centrifuge and centrifuged at 8000 rpm for 10 minutes. The supernatant after centrifugation is filtered through a 100 μm microporous membrane and then through an ultrafiltration membrane to obtain a collagen fermentation filtrate, wherein the molecular weight cut-off of the ultrafiltration membrane is less than 1000 Da; A3. Oligopeptide encapsulation: Add hydrogenated lecithin liposomes to the collagen fermentation filtrate at a ratio of 80-100 g / L, heat to 80-90°C in an ultrasonic homogenizer and homogenize for 30 minutes, then cool to room temperature for later use; A4. Secondary fermentation: Adjust the pH to 5.5 with hydrochloric acid to obtain acidic protein fermentation liquid; add astragalus extract to the homogenized collagen fermentation filtrate at a ratio of 200 g / L, and adjust the spore concentration to 1-5×10 5 A suspension of Aspergillus niger spores of 1000 spores / ml is added to the acidic protein fermentation broth at a volume ratio of 5-8:100, and cultured on a constant temperature shaker at 30-35°C and 200-250 rpm for 4-6 days to obtain a mixed fermentation broth for later use; A5. Secondary filtration: After sterilizing the mixed fermentation broth, filter it through a 100 μm microporous membrane and then an ultrafiltration membrane with a molecular weight cutoff of less than 1000 Da to obtain the target composition.
2. The composition containing cycloastragenol and oligopeptides according to claim 1, characterized in that: In step A1, the animal collagen powder is fish scale protein powder or pig skin protein powder with a purity of more than 90%.
3. Use of the composition containing cycloastragenol and oligopeptides according to claim 1 or 2 in anti-aging skin care products, characterized in that: The target composition is used directly as a skin care product or as an additive.
4. Use of the composition containing cycloastragenol and oligopeptides according to claim 3 in anti-aging skin care products, characterized in that: The target composition is vacuum freeze-dried to obtain a freeze-dried powder dosage form.
5. Use of the composition containing cycloastragenol and oligopeptides according to claim 3 in anti-aging skin care products, characterized in that: The anti-aging skin care product containing the target composition comprises the following raw materials in parts by weight:
6. Use of the composition containing cycloastragenol and oligopeptides according to claim 5 in anti-aging skin care products, characterized in that: The anti-aging skin care product further comprises 0.1 parts of scutellaria baicalensis extract and 0.1 parts of tetrandra stephania tetrandra extract.
7. Use of the composition containing cycloastragenol and oligopeptides according to claim 5 in anti-aging skin care products, characterized in that: The whitening agent comprises one or more of the following components: undecylenoylphenylalanine, raspberry ketone glucoside, 4-butylresorcinol, 5-octanoylsalicylic acid, and tetrahydrocurcumin.
8. Use of the composition containing cycloastragenol and oligopeptides in anti-aging skin care products according to claim 5, characterized in that: The emulsifier includes one or more of the following components: glyceryl stearate and glyceryl polyether-26.
9. Use of the composition containing cycloastragenol and oligopeptides in anti-aging skin care products according to claim 5, characterized in that: The thickener comprises one or more of the following components: carrageenan, xanthan gum, carbomer, distearate, and hydroxypropyl starch phosphate.