Composition with effects of controlling oil, removing dandruff and relieving itching as well as preparation method and application of composition

Abstract

The invention discloses a composition with effects of controlling oil, removing dandruff and relieving itching, the composition is prepared from the following components in parts by weight: 10-50 parts of a composite micelle carrier, 0.1-10 parts of dihydroquercetin and 0.1-50 parts of panthenol, and meanwhile, the invention also provides a preparation method and application of the composition. The solubility and bioavailability of the composition are improved through a process technology, the biological activity of the composition can be effectively protected, and the composition has good oil-controlling, dandruff-removing and itching-relieving effects and has a wide market prospect.

Description

Technical Field

[0001] The invention discloses a composition, a preparation method and an application thereof, and specifically, a composition with oil-controlling, anti-dandruff and antipruritic effects, a preparation method and an application thereof, belonging to the technical field of cosmetics. Background Art

[0002] In the development of personal care products, consumers are increasingly demanding comprehensive solutions for oil control, dandruff removal, and itching relief. Traditional products rely heavily on chemical ingredients such as zinc pyrithione and salicylic acid. Long-term use of zinc pyrithione can disrupt the scalp's oil-water balance, leading to dryness and even contact dermatitis, while also having little effect on relieving scalp itching. Salicylic acid, while dissolving cuticles to control oil, severely damages the scalp barrier, causing dry hair. It also fails to effectively address scalp itching, and its anti-dandruff effectiveness is gradually failing to meet demand. Silicone oils, commonly used in hair care, can temporarily improve hair smoothness, but they form a thick deposit on the hair surface, obstructing the breathing of hair follicles. This not only fails to relieve itching but can also worsen dandruff by affecting the scalp's microenvironment.

[0003] Although the application of plant extracts is gradually increasing, the synergistic effect between the various ingredients is not ideal. Taking tea tree essential oil extract as an example, its antibacterial and anti-dandruff capabilities are limited, and its efficacy in oil control and itching is single, which cannot fully meet consumers' expectations for multi-functional products. In addition, the delivery and stability of active ingredients are poor. Some antioxidants are easily inactivated during storage due to their unstable structure, which greatly reduces the actual improvement effect of the product on itching and dandruff caused by scalp inflammation. Dihydroquercetin, as a natural flavonoid compound, has strong antioxidant and anti-inflammatory biological activities. However, in the field of oil control, itching, and anti-dandruff efficacy compositions, its in-depth research and application are extremely scarce.

[0004] Therefore, it is very necessary to develop a composition that rationally combines copper chlorophyllin with plant oils and fats, improves their solubility and bioavailability through specific process technologies, effectively protects their biological activity, and has good oil-control, anti-dandruff and antipruritic effects. Summary of the Invention

[0005] In view of the above-mentioned shortcomings, the purpose of the present invention is to provide a composition that rationally combines copper chlorophyllin with plant oils and fats, and improves their solubility and bioavailability through specific process technologies, thereby effectively protecting their biological activity and having good oil-control, anti-dandruff and antipruritic effects. A preparation method and application of the composition are also provided.

[0006] To this end, the first technical solution provided by the present invention is as follows:

[0007] A composition with oil-controlling, anti-dandruff and antipruritic effects consists of the following components in parts by weight: 10-50 parts of a composite micelle carrier, 0.1-10 parts of dihydroquercetin and 0.1-50 parts of panthenol.

[0008] Furthermore, the composite micelle carrier consists of active substances, glycerol (ethylhexanoate), silk fibroin, glycerol and water.

[0009] Furthermore, the active ingredient consists of copper chlorophyllin and sunflower seed oil.

[0010] Furthermore, the mass ratio of copper chlorophyllin to sunflower seed oil in the active ingredient is 3:17.

[0011] Furthermore, the mass ratio of the active substance, glycerol (ethylhexanoate), silk fibroin, glycerol and water in the composite micelle carrier is 1:2:2:(20-80):(20-80).

[0012] Furthermore, the mass ratio of dihydroquercetin to panthenol is 1:(1-5).

[0013] The second technical solution provided by the invention is: a method for preparing a composition with oil-controlling, anti-dandruff and anti-itching effects, comprising the following steps:

[0014] A. Stir copper chlorophyllin, sunflower seed oil, and glyceryl (ethylhexanoate) at 45-50° C. using a stirrer at 500-800 rpm for 2-5 min until completely dissolved and clear, to obtain an oil phase;

[0015] B. Stir water, glycerol, and fibroin at 55-60° C. with a stirrer at 500-800 rpm for 5-10 minutes until completely dissolved to obtain an aqueous phase;

[0016] C. Cool the aqueous phase obtained in step B to 45-50° C., slowly add the oil phase obtained in step A to the oil phase obtained in step B while stirring, switch to homogenization and shearing at a speed of 8000-15000 rpm, and then perform high-pressure homogenization in an ultra-high pressure microfluidizer at a homogenization pressure of 20000-28000 PSI, circulate homogenization 2-5 times, and control the discharge temperature at 5-15° C. to obtain a composite micellar carrier;

[0017] D. In step C, the speed of adding the oil phase to the water phase is 5-10 mL / min, and the stirring speed is 500-800 rpm;

[0018] E. The obtained composite micelle carrier is stirred at room temperature at a speed of 500-800 rpm for 2-5 minutes, and is mixed evenly with dihydroquercetin and panthenol to obtain a composition with oil-controlling, anti-dandruff and anti-itching effects.

[0019] The third technical solution provided by the invention is: an application of the above composition, wherein the composition is used in the preparation of cosmetics.

[0020] Furthermore, the cosmetic is a skin external preparation prepared by using the composition with anti-photodamage efficacy as an active component and adding conventional pharmaceutical or cosmetic excipients or auxiliary ingredients.

[0021] Furthermore, the composition is added in an amount of 0.01-20% in cosmetics.

[0022] Furthermore, the composition is added to cosmetics in an amount of 0.1-15%.

[0023] Furthermore, it is characterized in that the cosmetics are one or more of lotion, essence, cream, mask, and gel.

[0024] Compared with the prior art, the present invention has the following beneficial effects:

[0025] 1. This invention utilizes ultrahigh-pressure microfluidization technology to create a composite micellar carrier by combining copper chlorophyllin, sunflower seed oil, glyceryl ethylhexanoate, silk fibroin, glycerol, and water. This technology addresses the difficulty in mixing oil-soluble copper chlorophyllin with water, dihydroquercetin, and panthenol. It not only stabilizes the ingredients but also facilitates their efficient combination, achieving the excellent performance of the composite.

[0026] 2. This invention combines a composite micellar carrier with dihydroquercetin and panthenol in a specific ratio to create a synergistic effect, achieving a 1+1>2 effect. Copper chlorophyllin provides anti-inflammatory and oil-control benefits, while working synergistically with dihydroquercetin and panthenol to enhance skin hydration and relieve inflammation. The addition of silk fibroin and other ingredients creates a mild formula with excellent biocompatibility, effectively moisturizing, soothing, and minimizing adverse reactions.

[0027] 3. This invention precisely controls the discharge temperature of the composite micelle carrier and ultrahigh-pressure microfluidizer technology to below 15°C, effectively avoiding the damage to the activity of copper chlorophyllin caused by high temperatures. Furthermore, this encapsulation process significantly enhances the stability of copper chlorophyllin, vegetable oils, and silk fibroin, ensuring their long-lasting activity during mixing and guaranteeing product quality and efficacy.

[0028] 4. The present invention abandons organic reagents such as ethanol and chloroform that are commonly used in traditional encapsulation technologies, which not only avoids harm to the human body and pollution to the environment, but also conforms to the concept of sustainable development. In addition, because the process is suitable for continuous scale-up production, it can significantly improve the production efficiency of traditional nanocarriers, while being environmentally friendly, helping the company achieve the goal of reducing costs and increasing efficiency. DETAILED DESCRIPTION

[0029] The following further describes the claims of the present invention in detail in conjunction with specific implementation methods, but does not constitute any limitation to the present invention. Any limited modifications made by anyone within the scope of protection of the claims of the present invention are still within the scope of protection of the claims of the present invention.

[0030] Example 1

[0031] The invention discloses a dihydroquercetin-containing composition with oil-controlling, anti-dandruff and antipruritic effects, which is prepared from the following raw materials in percentage by weight: 0.3g copper chlorophyllin, 1.7g sunflower seed oil, 4g glyceryl (ethylhexanoate), 4g silk fibroin, 4g dihydroquercetin, 50g glycerol, 31g water and 5g panthenol.

[0032] The composition of this embodiment is prepared by the following preparation method:

[0033] Step 1: stirring copper chlorophyllin, sunflower seed oil, and glyceryl (ethylhexanoate) at 45° C. and 800 rpm for 5 minutes until completely dissolved and clear, to obtain an oil phase;

[0034] Step 2: Stir glycerol, dihydroquercetin, and fibroin at 55° C. and 800 rpm for 10 min until completely dissolved to obtain an alcohol phase;

[0035] Step 3: Cool the alcohol phase obtained in step 2 to 45°C, slowly add the oil phase in step 1 to the alcohol phase obtained in step 2 while stirring, the speed of adding the oil phase to the alcohol phase is 10 mL / min, the stirring speed is 800 rpm, switch to homogenization shearing at a speed of 15000 rpm, and then perform high-pressure homogenization through an ultra-high pressure microfluidizer with a homogenization pressure of 25000 PSI. The mixture is circulated and homogenized 5 times, and the discharge temperature is controlled at 10°C to obtain a composite micelle carrier.

[0036] Step 4: Stir the obtained composite micelle carrier at 800 rpm for 5 minutes at room temperature, and mix it evenly with water and panthenol to obtain a dihydroquercetin-containing composition with oil-controlling, anti-dandruff and anti-itching effects.

[0037] Example 2

[0038] A dihydroquercetin-containing composition with oil-control, anti-dandruff and antipruritic properties is prepared from the following raw materials in percentage by weight: 0.2g copper chlorophyllin, 1.13g sunflower seed oil, 2.66g glyceryl (ethylhexanoate), 2.66g silk fibroin, 2.66g dihydroquercetin, 20g glycerol, 65.69g water, and 5g panthenol.

[0039] The composition of this embodiment is prepared by the following preparation method:

[0040] Step 1: stirring copper chlorophyllin, sunflower seed oil, and glyceryl (ethylhexanoate) at 45° C. and 800 rpm for 5 minutes until completely dissolved and clear, to obtain an oil phase;

[0041] Step 2: Stir glycerol, dihydroquercetin, and fibroin at 60° C. and 500 rpm for 8 minutes until completely dissolved to obtain an alcohol phase;

[0042] Step 3: Cool the alcohol phase obtained in step 2 to 50°C, slowly add the oil phase in step 1 to the alcohol phase obtained in step 2 while stirring, add the oil phase to the alcohol phase at a speed of 8 mL / min, stir at a speed of 500 rpm, switch to homogenization shearing at a speed of 8000 rpm, and then perform high-pressure homogenization by an ultra-high pressure microfluidizer at a homogenization pressure of 28000 PSI, cycle homogenization twice, and control the discharge temperature at 15°C to obtain a composite micelle carrier.

[0043] Step 4: Stir the obtained composite micelle carrier at 500 rpm for 3 minutes at room temperature, and mix it evenly with water and panthenol to obtain a dihydroquercetin-containing composition with oil-controlling, anti-dandruff and antipruritic effects.

[0044] Example 3

[0045] A dihydroquercetin-containing composition with oil-control, anti-dandruff and antipruritic effects is prepared from the following raw materials in percentage by weight: 0.1g copper chlorophyllin, 0.565g sunflower seed oil, 1.33g glyceryl (ethylhexanoate), 1.33g silk fibroin, 1.33g dihydroquercetin, 62.675g glycerol, 29.67g water, and 3g panthenol.

[0046] The composition of this embodiment is prepared by the following preparation method:

[0047] Step 1: stirring copper chlorophyllin, sunflower seed oil, and glyceryl (ethylhexanoate) at 48° C. and 700 rpm for 2 min until completely dissolved and clear, to obtain an oil phase;

[0048] Step 2: Stir glycerol, dihydroquercetin, and fibroin at 58° C. and 700 rpm for 5 minutes until completely dissolved to obtain an alcohol phase;

[0049] Step 3: Cool the alcohol phase obtained in step 2 to 48°C, slowly add the oil phase in step 1 to the alcohol phase obtained in step 2 while stirring, add the oil phase to the alcohol phase at a speed of 5 mL / min, stir at a speed of 700 rpm, switch to homogenization shearing at a speed of 12000 rpm, and then perform high-pressure homogenization by an ultra-high pressure microfluidizer at a homogenization pressure of 20000 PSI, cycle homogenization 4 times, and control the discharge temperature at 5°C to obtain a composite micelle carrier.

[0050] Step 4: Stir the obtained composite micelle carrier at 700 rpm for 2 minutes at room temperature, and mix it evenly with water and panthenol to obtain a dihydroquercetin-containing composition with oil-controlling, anti-dandruff and antipruritic effects.

[0051] Comparative Example 1

[0052] In this comparative example, the ultrahigh pressure microfluidizer treatment in Example 1 was replaced with homogenous stirring using conventional technology, while other aspects remained unchanged.

[0053] Comparative Example 2

[0054] In this comparative example, the copper chlorophyllin in Example 2 was removed and the remaining amount was supplemented with water, while other conditions remained unchanged.

[0055] Comparative Example 3

[0056] In this comparative example, the dihydroquercetin in Example 2 was removed and the remaining amount was supplemented with water, while other contents remained unchanged.

[0057] Comparative Example 4

[0058] In this comparative example, the discharge temperature of the material treated by the ultrahigh pressure microfluidizer in Example 1 was not controlled, and other parameters were kept unchanged.

[0059] Comparative Example 5

[0060] In this comparative example, the silk fibroin in Example 2 was replaced with polysorbate 80, a relatively common emulsifier in cosmetics, while other ingredients remained unchanged.

[0061] Table 1. Composition of Examples and Comparative Examples

[0062]

[0063]

[0064] In order to better illustrate the advantages of the present invention, the verification scheme provided by the present invention is given below:

[0065] Test Example 1: Accelerated stability performance test

[0066] This test is a one-month accelerated stability performance test of the compositions obtained in Examples 1-3 and Comparative Examples 1-5.

[0067] The composition prepared above was subjected to stability testing under normal temperature (room temperature), illumination (natural light), low temperature (-15°C), high temperature (45°C), high-low temperature cycling (45°C / -15°C for 24 hours each), and refrigeration (5°C). The data are recorded in Table 2.

[0068] Table 2. One-month accelerated stability performance test results of the composition

[0069] serial number normal temperature illumination Low temperature high temperature High and low temperature cycle refrigeration Example 1 No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities Example 2 No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities Example 3 No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities Comparative Example 1 Separation and stratification Faded layering Separation and stratification Faded layering Faded layering Separation and stratification Comparative Example 2 No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities Comparative Example 3 No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities Comparative Example 4 Separation and stratification Faded layering Separation and stratification Faded layering Faded layering Separation and stratification Comparative Example 5 Separation and stratification Faded layering Separation and stratification Faded layering Faded layering Separation and stratification

[0070] As shown in Table 2, the composite micelle carrier obtained by ultra-high pressure microfluidization technology, using silk fibroin as the membrane material and controlling the discharge temperature can better solve the stability problem of the compounding of oil-soluble copper chlorophyllin with dihydroquercetin, panthenol and water, and can better delay the fading problem of copper chlorophyllin. It also shows that the combination of silk fibroin and copper chlorophyllin with specific ultra-high pressure microfluidization technology can better solve the stability problem of the compounding between copper chlorophyllin and dihydroquercetin.

[0071] Test Example 2: Human skin patch test

[0072] This test involved the compositions obtained in Examples 1-3 and Comparative Examples 1-5, prepared as 10% aqueous solutions. Following the human skin patch test specified in the 2022 Cosmetic Safety Technical Specifications, skin reactions were observed at 30 minutes (after the indentation disappeared), 24 hours, and 48 hours, and the results were recorded. The data are summarized in Table 3.

[0073] Table 3. Human skin patch test results of the composition

[0074] serial number 30min 24h 48h Example 1 Level 0, 30 people Level 0, 30 people Level 0, 30 people Example 2 Level 0, 30 people Level 0, 30 people Level 0, 30 people Example 3 Level 0, 30 people Level 0, 30 people Level 0, 30 people Comparative Example 1 Level 0, 30 people Level 0, 30 people Level 0, 30 people Comparative Example 2 Level 0, 30 people Level 0, 30 people Level 0, 30 people Comparative Example 3 Level 0, 30 people Level 0, 30 people Level 0, 30 people Comparative Example 4 Level 0, 30 people Level 0, 30 people Level 0, 30 people Comparative Example 5 Level 0, 30 people Level 0, 30 people Level 0, 30 people

[0075] As shown in Table 3, the composition is non-irritating when added in an amount of up to 10%, and can be used safely within this range.

[0076] Test Example 3: 5α-reductase inhibition test (oil control)

[0077] This test is conducted on the compositions obtained in Examples 1-3 and Comparative Examples 1-5, which were prepared into 2% concentration samples.

[0078] The experimental method of this test is as follows: add 1mL PBS solution to the blank control group, add 1mL sample working solution to the sample group, add 1mL finasteride working solution to the positive control group, and add 1mL 5% ethanol to the enzyme tube. Add 1mL enzyme solution, 1mL NADPH solution and 1mL testosterone solution to the test tube, set up 3 parallel tubes, shake gently, take 200μL with a pipette and add it to a 96-well enzyme-labeled plate, place it in an enzyme-labeled instrument for detection, and measure the absorbance at 340nm as the first measurement value A0. After incubation at 37℃ for 30min, place it in an enzyme-labeled instrument for detection, and measure the absorbance at 340nm as the second measurement value A 30 , and the 5α-reductase inhibition rate was detected. The test results are shown in Table 4.

[0079] Wherein, 5α-reductase inhibition rate (%) = (1-(A 样品0 -A 样品30 ) / (A 酶0 -A 酶30 ))×100%, where A 样品0 The absorbance value of the first sample group (0min) is measured, A 样品30 The absorbance value of the second sample group (30min) is measured, A 酶0 A is the average absorbance of the first (0 min) enzyme tube measurement, 酶30 It is the average value of absorbance measured in the enzyme tube for the second time (30 min).

[0080] Table 4. Test results of 5α-reductase inhibition rate test

[0081]

[0082]

[0083] Note: If P>0.05, it means there is no significant difference, which is recorded as "ns"; if P<0.05, it means there is a significant difference, and 0.01<P≤0.05, it is recorded as "*"; 0.001<P≤0.01, it is recorded as "**"; 0.0001<P≤0.001, it is recorded as "***"; P≤0.0001, it is recorded as "****".

[0084] As shown in Table 4, the 5α-reductase inhibition rates of the compositions of Examples 1-3 were all above 25%, while those of the compositions of Comparative Examples 1-5 were all below 20%. These results demonstrate that the composite micelle carrier prepared through ultrahigh-pressure microfluidization, the use of silk fibroin as the membrane material, and strict control of the discharge temperature are sufficient to fully unleash the oil-control efficacy of the combination of copper chlorophyllin, dihydroquercetin, and panthenol. This further confirms that only when silk fibroin and copper chlorophyllin are processed in specific ratios and with specific technical processes can they achieve a synergistic oil-control effect with panthenol.

[0085] Test Example 4: Antibacterial Effect Test

[0086] The plate punching method was used to puncture the sample with a concentration of 5×10 4 CFU / ml of Malassezia furfur was evenly spread on the surface of the nutrient agar plate culture medium and placed at room temperature to dry for 10 minutes. Then, a sterile circular punch with a diameter of 6 mm was used to punch holes, and 2 ml of the composition samples prepared in Examples 1-3 and Comparative Examples 1-5 were diluted 100 times with normal saline and added to the holes until full without overflowing. Three sets of parallel experiments were performed. Subsequently, the culture dish was placed in a constant temperature incubator at (37 ± 1) ° C and cultured for 24 hours. The dish was taken out for observation and the diameter of the inhibition zone (cm) was measured with a vernier caliper, with the outer edge of the inhibition zone with no colony growth as the boundary. The results were determined according to the standards of the National Committee for Clinical Trials Standards (NCCLS): the inhibition zone diameter <8 mm was insensitive, 8 to 13 mm was low sensitive, 13 to 19 mm was moderately sensitive, and >19 mm was highly sensitive. The results are shown in Table 5.

[0087] Table 5. Antibacterial effect test results of the composition

[0088] serial number Inhibition zone diameter / cm Example 1 23.87 Example 2 22.63 Example 3 21.56 Comparative Example 1 12.88 Comparative Example 2 9.13 Comparative Example 3 10.86 Comparative Example 4 11.58 Comparative Example 5 12.16

[0089] As shown in Table 5, the diameters of the inhibition zones of the composition samples of Examples 1-3 are all above 20 cm, indicating that they are highly sensitive to Malassezia furfur and have good antibacterial and antidandruff effects, while the diameters of the inhibition zones of the composition samples of Comparative Examples 1-5 are all below 13 cm, indicating that they are lowly sensitive to Malassezia furfur and have no good antibacterial and antidandruff effects. The results show that by means of ultra-high pressure microfluidization homogenization technology, with silk fibroin as the membrane material, and precise control of the discharge temperature, the composite micelle carrier prepared can efficiently stimulate the antibacterial and antidandruff effects of copper chlorophyllin, dihydroquercetin and panthenol after compounding. It also shows that only when silk fibroin and copper chlorophyllin are in a specific ratio and are processed by a specific technical process can the ideal antibacterial and antidandruff synergistic effect be exerted.

[0090] Test Example 5: Human efficacy test on anti-dandruff and anti-itching

[0091] This test is conducted on the compositions obtained from Examples 1-3 and Comparative Examples 1-5, and the compositions were added in an amount of 5% to a basic shampoo formula product for testing.

[0092] Test subjects: 30 volunteers (29 women, aged 18-40 years old; 1 man, aged 31-40 years old) with itchy scalps, excessive dandruff, and high sebum secretion served as trial subjects. Before the test, there was no statistical difference in the individual conditions of each group of subjects.

[0093] How to use: Wet your hair with clean water first, then rub the shampoo on your hair to make foam, and then rinse with clean water. The amount used each time is 5g to 10g.

[0094] Scoring Criteria: Based on the three indicators of dandruff removal, itching relief, and oil control, volunteers rated their shampoos on a six-point scale: 0 = no improvement, 1 = slight improvement, 2 = slightly improved, 3 = marked improvement, 4 = significantly improved, and 5 = completely improved. The average scores of the eight shampoo groups were calculated after three consecutive uses. The results are shown in Table 6.

[0095] Table 6. Test results of the anti-dandruff and antipruritic efficacy of the composition on human body

[0096] serial number Anti-dandruff effect Antipruritic effect Oil control effect Example 1 4.9 5 4.6 Example 2 4.5 4.8 4.3 Example 3 4.3 4.2 4 Comparative Example 1 2.6 2.2 2.3 Comparative Example 2 1.6 1.5 1.5 Comparative Example 3 1.8 1.7 1.6 Comparative Example 4 2.1 1.8 1.9 Comparative Example 5 2.3 2.6 2.5

[0097] As can be seen from Table 6, volunteers used shampoos with the addition of the compositions of Examples 1-3, which significantly improved their anti-dandruff, anti-itching and oil control effects, while those using shampoos with the addition of the compositions of Comparative Examples 1-5 did not significantly improve their anti-dandruff, anti-itching and oil control effects. The results show that the composite micelle carrier prepared by ultra-high pressure microfluidization homogenization technology, using silk fibroin as the membrane material and precisely controlling the discharge temperature, can efficiently stimulate the anti-dandruff and anti-itching effects of copper chlorophyllin, dihydroquercetin and panthenol after compounding. Only when silk fibroin and copper chlorophyllin are treated in a specific ratio through a specific technical process can they exert an ideal antibacterial and anti-dandruff synergistic effect, thereby effectively improving the performance of shampoo in anti-dandruff, anti-itching and oil control.

[0098] The above embodiments are preferred implementation modes of the present invention, but the implementation modes of the present invention are not limited to the above embodiments. Any other changes, modifications, substitutions, combinations, and simplifications that do not deviate from the spirit and principles of the present invention should be considered as equivalent replacement methods and are included in the scope of protection of the present invention.

Claims

1. A composition with oil-controlling, anti-dandruff and antipruritic effects, characterized in that: The invention is composed of the following components in parts by weight: 10 to 50 parts of composite micelle carrier, 20 to 80 parts of water and 0.1 to 50 parts of panthenol.

2. The composition according to claim 1, characterized in that The composite micelle carrier consists of active substances, glycerol (ethylhexanoate), silk fibroin, glycerol and dihydroquercetin.

3. The composition according to claim 1, characterized in that The actives consist of copper chlorophyllin and sunflower seed oil.

4. The composition according to claim 1, characterized in that The mass ratio of copper chlorophyllin to sunflower seed oil in the active ingredient is 3:

17.

5. The composition according to claim 1, characterized in that The mass ratio of the active substance, glycerol (ethylhexanoate), silk fibroin, glycerol and water in the composite micelle carrier is 1:2:2:(20-80):(20-80).

6. The composition according to claim 1, characterized in that The mass ratio of the dihydroquercetin to panthenol is 1:(1-5).

7. A method for preparing a composition having oil-controlling, anti-dandruff and antipruritic effects according to any one of claims 1 to 6, characterized in that: It consists of the following steps: A. Stir copper chlorophyllin, sunflower seed oil, and glyceryl (ethylhexanoate) at 45-50° C. using a stirrer at 500-800 rpm for 2-5 min until completely dissolved and clear, to obtain an oil phase; B. Stir water, glycerol, and fibroin at 55-60° C. with a stirrer at 500-800 rpm for 5-10 minutes until completely dissolved to obtain an aqueous phase; C. Cool the aqueous phase obtained in step B to 45-50° C., slowly add the oil phase obtained in step A to the oil phase obtained in step B while stirring, switch to homogenization and shearing at a speed of 8000-15000 rpm, and then perform high-pressure homogenization in an ultra-high pressure microfluidizer at a homogenization pressure of 20000-28000 PSI, circulate homogenization 2-5 times, and control the discharge temperature at 5-15° C. to obtain a composite micellar carrier; D. In step C, the speed of adding the oil phase to the water phase is 5-10 mL / min, and the stirring speed is 500-800 rpm; E. The obtained composite micelle carrier is stirred at room temperature at a speed of 500-800 rpm for 2-5 minutes, and is mixed evenly with dihydroquercetin and panthenol to obtain a composition with oil-controlling, anti-dandruff and anti-itching effects.

8. Use of a composition having oil-controlling, anti-dandruff and antipruritic effects according to any one of claims 1 to 6 in the preparation of cosmetics, characterized in that: The cosmetic is a skin external preparation prepared by using the composition with oil-controlling, anti-dandruff and itching-relieving effects as an active component and adding conventional pharmaceutical or cosmetic excipients or auxiliary ingredients.

9. The use according to claim 8, characterized in that The composition is added in an amount of 0.01-20% in cosmetics.

10. The use according to claim 8, characterized in that The cosmetics are one or more of lotion, essence, cream, mask, and gel.

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