Mosquito repellent paste capable of quickly relieving itching as well as preparation method and application of mosquito repellent paste

Abstract

The invention discloses a mosquito repellent paste capable of quickly relieving itching, a preparation method and an application. The mosquito repellent paste is prepared from the following components in percentage by mass: 1-100% of camellia seed oil; 1%-50% of a wormwood extract; 1%-50% of a mint extract; 1%-20% of borneol; 1%-20% of mentholum; 1%-20% of sweet almond oil; 1%-20% of jojoba oil; the mosquito-repelling paste does not contain preservatives, artificial pigments and synthetic essence, and the mosquito-repelling, itching-relieving and skin-repairing functions are achieved through the synergistic effect of the vegetable oil matrix and the plant active ingredients. The wormwood extract and the mint extract are compounded to form a natural mosquito repelling barrier, the repelling rate of common mosquitoes (such as aedes and culex) is larger than or equal to 95% (within 4 hours), and the protection time reaches 4-6 hours.

Description

Technical Field

[0001] The invention relates to the technical field of external-use mosquito repellent and antipruritic compositions, and in particular to a mosquito repellent cream for quickly relieving itching, a preparation method and application thereof. Background Art

[0002] Mosquito bites not only cause itching and redness, but can also spread diseases like dengue fever and malaria. Currently, commercially available mosquito repellents and anti-itch products often contain synthetic chemical ingredients (such as DEET and camphor), which can irritate the skin with long-term use, posing a safety risk, especially to infants, pregnant women, and those with sensitive skin.

[0003] 1. Existing natural mosquito repellent products have the following problems:

[0004] 2. Short mosquito repellent effect - plant essential oils are volatile and the protection time is insufficient;

[0005] 3. Slow anti-itching effect - Traditional herbal ointments take a long time to take effect and cannot quickly relieve severe itching;

[0006] 4. The skin feels greasy - the oil matrix is ​​thick, affecting the user experience.

[0007] Therefore, a mosquito repellent cream that quickly relieves itching, a preparation method and applications thereof are in urgent need of disclosure. Summary of the Invention

[0008] To solve the above technical problems, the present invention provides a technical solution: a mosquito repellent cream that quickly relieves itching, a preparation method and application thereof, which is composed of the following ingredients in the following mass percentages:

[0009] Camellia seed oil 1%-100%;

[0010] Mugwort extract 1%-50%;

[0011] Peppermint extract 1%-50%;

[0012] Borneol 1%-20%;

[0013] Mint ice 1%-20%;

[0014] Sweet almond oil 1%-20%;

[0015] Jojoba oil 1%-20%;

[0016] The mosquito repellent cream does not contain preservatives, artificial pigments and synthetic flavors, and achieves mosquito repellent, itching relief and skin repair functions through the synergistic effect of a plant oil matrix and plant active ingredients.

[0017] Furthermore, the mass ratio of the wormwood extract to the mint extract is 1:1, which synergistically exerts anti-inflammatory, mosquito repellent and instant cooling effects.

[0018] Furthermore, the borneol and menthol ice are compounded to form a fast-acting antipruritic system, with a mass ratio of 1:1, which relieves itching through the dual mechanisms of local vasoconstriction and nerve ending sedation.

[0019] Furthermore, the mass ratio of the sweet almond oil to the jojoba oil is 1:1, forming a skin repair matrix, and synergistically promoting the repair of the skin barrier after a bite through vitamin E, fatty acids and sebum-like components.

[0020] Analysis of the pharmacological effects of each component of mosquito repellent cream

[0021] 1. Camellia Seed Oil

[0022] Main active ingredients: tea polyphenols, oleic acid, squalene, vitamin E

[0023] Pharmacological action:

[0024] Anti-inflammatory: Tea polyphenols inhibit the COX-2 and NF-κB pathways, reduce the production of prostaglandins (PGE2), and relieve redness and swelling after bites.

[0025] Antioxidant: Vitamin E scavenges free radicals and prevents oxidative damage to the bite site.

[0026] Promote penetration: Oleic acid acts as a natural penetration enhancer, enhancing the transdermal absorption of other ingredients (such as borneol and mint ice).

[0027] 2. Mugwort Extract

[0028] Main active ingredients: eucalyptol, camphor, β-caryophyllene

[0029] Pharmacological action:

[0030] Mosquito repellent: Eucalyptus interferes with mosquito olfactory receptors and masks the odor of human CO2 and lactic acid (repellent rate ≥ 90%, GB / T17322.10 test).

[0031] Anti-allergic: β-caryophyllene inhibits histamine release through TRPV1 channels and relieves itching.

[0032] Antibacterial: The diameter of the inhibition zone of camphor against Staphylococcus aureus is 12mm (agar diffusion method).

[0033] 3. Peppermint Extract

[0034] Main active ingredients: Menthol, Menthone

[0035] Pharmacological action:

[0036] Instant anti-itching: Menthol activates the skin's TRPM8 cold receptors, producing a cooling sensation and masking the itching sensation (onset time < 3 minutes).

[0037] Anti-inflammatory: Inhibits TNF-α and IL-6 secretion (IC50=15.2 μg / mL, LPS-induced macrophage model).

[0038] 4. Borneol

[0039] Chemical structure: Monoterpene alcohol

[0040] Pharmacological action:

[0041] Nerve calming: Enhances GABAa receptor activity and reduces itch signal transmission (reduced by 62% in mouse scratching test).

[0042] Promotes penetration: destroys the orderly arrangement of stratum corneum lipids, increasing the drug transdermal rate by 3.2 times (Franz diffusion cell test).

[0043] 5. Mint Ice

[0044] Difference from menthol: purity >99%, stronger effect

[0045] Pharmacological mechanism:

[0046] Vasoconstriction: It constricts capillaries through α1-adrenergic receptors, reducing edema after bites (diameter reduction of 40%, observed under confocal microscopy).

[0047] Antipruritic synergy: Combination with borneol can prolong the antipruritic time to 4 hours (vs 1.5 hours when used alone).

[0048] 6. Sweet almond oil

[0049] Key ingredients: Oleic acid (60%), linoleic acid (30%), vitamin E

[0050] Skin repair mechanism:

[0051] Barrier repair: Linoleic acid promotes ceramide synthesis and repairs the stratum corneum (TEWL value is reduced by 35%).

[0052] Anti-scarring: Vitamin E inhibits the TGF-β1 / Smad pathway and reduces excessive collagen deposition (rat wound model).

[0053] 7. Jojoba Oil

[0054] Unique properties: liquid wax ester (97% long-chain fatty acids + alcohols)

[0055] Pharmacological properties:

[0056] Sebum-like compatibility: 98% similar to human sebum, can regulate sebaceous gland secretion (sebum secretion is reduced by 22% after use on oily skin).

[0057] Anti-inflammatory: Reduces IL-1β expression through the PPAR-γ pathway (ELISA detection concentration decreased by 48%).

[0058] Analysis of synergistic effects of components:

[0059]

[0060] The advantages of the invention compared with the prior art are:

[0061] 1. Highly effective mosquito repellent, long-lasting protection

[0062] A blend of mugwort extract and peppermint extract creates a natural mosquito repellent barrier, repelling ≥95% of common mosquitoes (such as Aedes and Culex) within 4 hours. The protection lasts 4-6 hours, outperforming commercially available plant-based repellents (typically 2-3 hours). Camellia seed oil, used as a carrier oil, slows the evaporation of the plant's active ingredients and enhances their long-lasting effect.

[0063] 2. Rapid itching relief and strong analgesia

[0064] The synergistic effect of mint ice and borneol relieves itching within 5 minutes by constricting blood vessels (reducing redness and swelling) and inhibiting the transmission of itch signals to nerve endings (blocking the itch sensation). Clinically tested, this product has an efficacy rate of ≥90%. Compared to traditional wind oil (which contains camphor and may irritate the skin), this product is non-irritating and suitable for repeated application.

[0065] 3. Repair skin and reduce pigmentation

[0066] Sweet almond oil is rich in vitamin E, which fights free radicals, slows aging, and reduces fine lines. It can be added to daily face creams or serums to enhance skincare, promote the repair of bites, and reduce scarring and hyperpigmentation caused by scratching. It's also rich in vitamin E and fatty acids, which penetrate the skin to lock in moisture and improve dryness and roughness, making it particularly suitable for sensitive skin and autumn and winter skincare. Sweet almond oil also softens cuticles, relieves redness and tightness, and helps repair damaged skin barrier, such as those caused by sunburn or dryness.

[0067] Jojoba oil simulates human sebum, strengthens the skin barrier and prevents secondary infection after mosquito bites. DETAILED DESCRIPTION

[0068] The present invention is described in further detail below.

[0069] The present invention provides a mosquito repellent cream for rapid itching relief, a preparation method and an application thereof, which is composed of the following components in percentage by mass:

[0070] Camellia seed oil 1%-100%;

[0071] Mugwort extract 1%-50%;

[0072] Peppermint extract 1%-50%;

[0073] Borneol 1%-20%;

[0074] Mint ice 1%-20%;

[0075] Sweet almond oil 1%-20%;

[0076] Jojoba oil 1%-20%;

[0077] The mosquito repellent cream does not contain preservatives, artificial pigments and synthetic flavors, and achieves mosquito repellent, itching relief and skin repair functions through the synergistic effect of a plant oil matrix and plant active ingredients.

[0078] Example 1:

[0079] The best anti-itch mosquito repellent cream ratio: Camellia seed oil: 50%;

[0080] Artemisia annua extract (concentrated 5:1): 20%;

[0081] Peppermint extract (menthol content ≥30%): 20%;

[0082] Borneol (synthetic borneol): 5%;

[0083] Mint ice (purity ≥99%): 2%;

[0084] Sweet almond oil: 2%;

[0085] Jojoba oil: 1%.

[0086] Preparation process:

[0087] (1) Extraction of active ingredients from mugwort: Heat camellia seed oil to 70±2°C, add mugwort extract, stir at constant temperature for 1.5 hours, and filter to remove residue.

[0088] (2) Cooling and dissolving: Cool to below 40°C, add peppermint extract, borneol, and mint ice in sequence, and stir at 800 rpm until completely dissolved (about 20 minutes).

[0089] (3) Emulsification and homogenization: add sweet almond oil and jojoba oil, emulsify with a homogenizer (10000 rpm, 5 minutes), cool to room temperature and fill.

[0090] An anti-itching test was conducted using the mosquito repellent cream formulation of this embodiment. 30 volunteers applied the cream after being bitten by mosquitoes, and the itching relief rate within 3 minutes was 96.7%.

[0091] Example 2:

[0092] The composition of the anti-itch ointment for sensitive skin:

[0093] Camellia seed oil: 70%;

[0094] Mugwort extract: 10%;

[0095] Peppermint extract: 10%;

[0096] Borneol: 3%;

[0097] Mint Ice: 2%;

[0098] Sweet almond oil: 3%;

[0099] Jojoba oil: 2%.

[0100] This embodiment reduces the content of mint and borneol to reduce cold stimulation, increases the proportion of jojoba oil, and enhances barrier repair.

[0101] The usage test of this embodiment is as follows: 30 subjects with sensitive skin were given a 48-hour occlusive application, and none of them developed erythema or edema.

[0102] As a further elaboration of the invention, the mass ratio of the mugwort extract to the mint extract is 1:1, which synergistically exerts anti-inflammatory, mosquito repellent and instant cooling effects.

[0103] Example 3:

[0104] The ingredients of the long-lasting release anti-itch mosquito repellent cream for outdoor use are as follows:

[0105] Camellia seed oil: 40%;

[0106] Mugwort extract: 25%;

[0107] Peppermint extract: 25%;

[0108] Borneol: 4%;

[0109] Mint Ice: 3%;

[0110] Sweet almond oil: 1%;

[0111] Jojoba oil: 2%;

[0112] New sustained-release agent: beeswax 2% (extends the release of mosquito repellent ingredients).

[0113] The performance comparison table of this embodiment is as follows:

[0114] index This embodiment Commercially available DEET spray Mosquito repellent time (h) 6.5 8.0 Antipruritic effect (min) 2 No such feature Skin irritation none Mild stinging

[0115] Example 4:

[0116] The formula of the repair and anti-itch ointment for skin is adjusted as follows: sweet almond oil is increased to 5%, jojoba oil is increased to 5%, and 0.5% dipotassium glycyrrhizate is added (for anti-inflammatory assistance).

[0117] In order to enhance the anti-itching effect of the mosquito repellent cream, the borneol and menthol ice are compounded to form a fast-acting anti-itching system with a mass ratio of 1:1, which relieves itching through the dual mechanisms of local vasoconstriction and nerve ending sedation.

[0118] In order to quickly repair the skin barrier, the mass ratio of the sweet almond oil to the jojoba oil is 1:1, forming a skin repair matrix, and synergistically promoting the repair of the skin barrier after a bite through vitamin E, fatty acids and sebum-like components.

[0119] A method for preparing a mosquito repellent cream that quickly relieves itching, comprising the following steps:

[0120] a) heating camellia seed oil to 60-80° C., adding wormwood extract, and extracting at a constant temperature for 1-2 hours;

[0121] b) cooling to below 40° C., adding peppermint extract, borneol, and menthol ice in sequence and stirring until completely dissolved;

[0122] c) Finally, add sweet almond oil and jojoba oil, homogenize and cool to form.

[0123] Application of mosquito repellent cream:

[0124] (1) Used to prevent and repel mosquito bites;

[0125] (2) Used to relieve redness, swelling, pain and itching after insect bites;

[0126] (3) It can be used to promote skin repair at the bite site and reduce scar formation.

[0127] The above description of the present invention and its embodiments is non-limiting. In short, if a person skilled in the art is inspired by the above description and designs a similar structure and embodiment to the technical solution without departing from the purpose of the present invention, they should fall within the scope of protection of the present invention.

Claims

1. A mosquito repellent cream that quickly relieves itching, characterized in that: It is composed of the following components in percentage by mass: Camellia seed oil 1%-100%; Mugwort extract 1%-50%; Peppermint extract 1%-50%; Borneol 1%-20%; Mint ice 1%-20%; Sweet almond oil 1%-20%; Jojoba oil 1%-20%; The mosquito repellent cream does not contain preservatives, artificial pigments and synthetic flavors, and achieves mosquito repellent, itching relief and skin repair functions through the synergistic effect of a plant oil matrix and plant active ingredients.

2. A mosquito repellent cream for rapid itching relief according to claim 1, characterized in that: The mass ratio of the wormwood extract to the mint extract is 1:1, and they synergistically exert anti-inflammatory, mosquito repellent and instant cooling effects.

3. The mosquito repellent cream for rapid itching relief according to claim 1, characterized in that: The borneol and menthol ice are compounded to form a fast-acting antipruritic system, with a mass ratio of 1:1, which relieves itching through the dual mechanisms of local vasoconstriction and nerve ending sedation.

4. The mosquito repellent cream for rapid itching relief according to claim 1, characterized in that: The mass ratio of the sweet almond oil to the jojoba oil is 1:1, which constitutes a skin repair matrix and synergistically promotes the repair of the skin barrier after a bite through vitamin E, fatty acids and sebum-like components.

5. A method for preparing a mosquito repellent cream that quickly relieves itching, characterized in that: The method comprises the following steps: a) heating camellia seed oil to 60-80° C., adding wormwood extract, and extracting at a constant temperature for 1-2 hours; b) cooling to below 40° C., adding peppermint extract, borneol, and menthol ice in sequence and stirring until completely dissolved; c) Finally, add sweet almond oil and jojoba oil, homogenize and cool to form.

6. Application of the mosquito repellent cream according to any one of claims 1 to 4: (1) Used to prevent and repel mosquito bites; (2) Used to relieve redness, swelling, pain and itching after insect bites; (3) It can be used to promote skin repair at the bite site and reduce scar formation.

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