Mixing device and composite nanoparticle preparation method
Through the use of a mixing device and image analysis technology, the problem of sufficient mixing was solved, more accurate stirring control and improved production efficiency were achieved, and targeted hyaluronic acid-zein-curcumin composite nanoparticles were prepared, solving the problem of difficult stirring time control in the existing technology, improving production efficiency and enhancing drug targeting.
Patent Information
- Application Number
- CN202510716304.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-05-30
- Publication Date
- 2025-09-12
AI Technical Summary
In the prior art, the judgment of whether mixing and dissolution are sufficient relies on experience, resulting in excessively long stirring time, which is difficult to accurately control and affects production efficiency.
A mixing device, including a stirring shaft, a baffle, and a visual component, is used to determine the presence of solute particles through image analysis to ensure sufficient mixing and avoid excessive stirring. The preparation method of hyaluronic acid-zein-curcumin composite nanoparticles is used to combine electrostatic adsorption and physical cross-linking to improve drug targeting.
It achieves more intuitive and accurate control of the stirring process, avoids unnecessary stirring time, improves production efficiency, and prepares targeted composite nanoparticles.
Smart Images
Figure CN120618293A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of nano drug delivery, and in particular to a mixing device and a method for preparing composite nanoparticles. Background Art
[0002] Mixing is a common method used in pharmaceutical and chemical production, often used to blend or dissolve components. Currently, the adequacy of mixing and dissolution is often determined based on experience, such as by specifying specific mixing times or by manual observation. These methods fail to accurately determine the actual mixing effect and make it difficult to precisely control the mixing time.
[0003] In addition, in order to ensure sufficient mixing, the mixing time usually used is relatively long. Although this can avoid insufficient mixing to a certain extent, it also directly slows down the production progress.
[0004] In view of this, this application is hereby filed. Summary of the Invention
[0005] The first purpose of the present invention is to provide a mixing device that can control the actual stirring process more intuitively and accurately, facilitate more reasonable determination of the stirring time, and effectively avoid excessive stirring on the basis of ensuring sufficient mixing, thereby helping to avoid unnecessary stirring time and improving production efficiency.
[0006] A second object of the present invention is to provide a method for preparing hyaluronic acid-zein-curcumin composite nanoparticles. While ensuring thorough mixing, the method effectively avoids excessive stirring, helps eliminate unnecessary stirring time, and improves production efficiency. Furthermore, the method is simple and rapid, making it easy to implement. The prepared composite nanoparticles not only act as stabilizers to improve the efficiency of zein loading with curcumin, but also serve as target heads, specifically enhancing the drug's macrophage targeting, as they are physically cross-linked to the cationic zein surface via electrostatic adsorption.
[0007] The embodiment of the present invention is achieved as follows:
[0008] A mixing device comprises a mixing chamber, a stirring shaft, a stirring element, a first extension rod, a fixing seat, a baffle, a driving component, a visual component and a processor.
[0009] The stirring shaft is arranged along the depth direction of the mixing bin and is driven by a driver. The stirring member is connected to the stirring shaft. The first extension rod is connected to the stirring shaft and is arranged along the radial direction of the stirring shaft.
[0010] The fixing seat is cylindrical and fixedly connected to the first extension rod. The central axis of the fixing seat is arranged parallel to the central axis of the stirring shaft.
[0011] The baffle is arc-shaped, with the central axis of the cylindrical surface corresponding to the baffle being parallel to the central axis of the fixed base. The baffle is positioned adjacent to the sidewall of the fixed base and along its circumference. The baffle has opposing first and second ends, with the spacing between the first end and the fixed base greater than the spacing between the second end and the fixed base. The baffle is driven by a drive assembly to rotate along the circumference of the fixed base, with the first end positioned forward of the second end in the direction of rotation of the baffle. The baffle is made of an opaque material.
[0012] The side wall of the fixing seat is provided with a mounting groove which is arranged along the radial direction of the fixing seat. The visual component is installed in the mounting groove, and the mouth of the mounting groove is closed by a transparent window.
[0013] The visual component is electrically connected to the processor, and the processor is used to determine whether solute particles exist based on image data collected by the visual component, and then determine whether the solute particles are fully dissolved.
[0014] Furthermore, the processor is also used to determine whether there are foreign particles based on the image data collected by the visual component, and then determine whether the mixed phase is qualified.
[0015] Furthermore, the driving assembly includes: a second extension rod, a transmission wheel and a reference seat.
[0016] The base is fixedly connected to the inner bottom wall of the mixing bin, and the bottom end of the stirring shaft is rotatably matched with the base. The base has an annular flange, which is coaxially arranged with the stirring shaft and has an outer gear ring.
[0017] The second extension rod is fixedly connected to the agitator shaft and disposed radially along the agitator shaft. The second extension rod is disposed parallel to and juxtaposed with the first extension rod. A transmission wheel is rotatably coupled to the second extension rod, with the rotational axis of the transmission wheel being parallel to the central axis of the agitator shaft. The transmission wheel has an outer gear ring on its surface and engages with an annular flange.
[0018] The transmission wheel and the baffle are in transmission cooperation.
[0019] Furthermore, there are multiple fixing seats along the length direction of the first extension rod, and each fixing seat is correspondingly provided with a blocking piece.
[0020] There are multiple transmission wheels along the length direction of the second extension rod, and each baffle is correspondingly provided with a transmission wheel. The transmission wheels are meshed with each other in sequence, and the transmission wheel located at one end of the second extension rod near the stirring shaft is meshed with the annular flange.
[0021] Furthermore, the driving assembly also includes: a turntable.
[0022] The transmission wheel and the fixing seat are coaxially arranged.
[0023] A turntable is rotatably coupled to one side of the fixed seat close to the transmission wheel, and a rotation axis of the turntable coincides with a central axis of the fixed seat. A baffle is fixedly connected to the turntable.
[0024] The transmission wheel is coaxially fixedly connected with a transmission shaft, and the transmission shaft is fixedly connected to the turntable.
[0025] Furthermore, the transparent window is made of a convex lens.
[0026] A method for preparing hyaluronic acid-zein-curcumin composite nanoparticles comprises the following steps:
[0027] S1. Use the above-mentioned mixing device to completely dissolve the hyaluronic acid powder in distilled water to obtain a hyaluronic acid solution.
[0028] S2. Dissolve zein and curcumin in 70% ethanol using the above-mentioned mixing device to obtain a zein-curcumin-ethanol solution.
[0029] S3. While stirring, drop the zein-curcumin-ethanol solution into the hyaluronic acid solution, and stir to form a hyaluronic acid-zein solution encapsulating curcumin.
[0030] S4. Evaporating the ethanol in the hyaluronic acid-zein solution encapsulating curcumin, centrifuging the solution at room temperature, and washing the solution with distilled water to obtain hyaluronic acid-zein-curcumin composite nanoparticles.
[0031] The beneficial effects of the technical solutions of the embodiments of the present invention include:
[0032] During the mixing process of the mixing device provided by the embodiments of the present invention, the stirring shaft drives the stirring member to move, which directly stirs the mixed phase. Simultaneously, the stirring shaft also synchronously drives the first extension rod to rotate. During the rotation of the first extension rod, the drive assembly drives the baffle to move along the circumference of the fixed base.
[0033] On the one hand, the baffle can enhance the stirring effect. On the other hand, during the rotation process, the baffle can also guide the mixed phase around the fixed seat to the side wall of the fixed seat. When the baffle moves to the transparent window, the baffle can serve as a light-blocking backplane, making it easier for the light source of the visual component to fully illuminate the mixed phase between the baffle and the transparent window, thereby facilitating the lens of the visual component to collect image data at this location.
[0034] The processor performs image analysis based on the image data. If solute particles can still be identified in the image data, it means that the solute has not yet fully dissolved. If no solute particles are identified within a certain period of time, it means that the solute has achieved a good dissolution effect. This allows for more intuitive and accurate control of the actual dissolution process, thereby facilitating more reasonable management and control of the mixing time.
[0035] In general, the mixing device provided in the embodiment of the present invention can control the actual stirring process more intuitively and accurately, facilitate more reasonable determination of the stirring time, and effectively avoid excessive stirring on the basis of ensuring sufficient mixing, thereby helping to avoid unnecessary stirring time and improving production efficiency.
[0036] The method for preparing hyaluronic acid-zein-curcumin composite nanoparticles provided in the embodiments of the present invention effectively avoids excessive stirring while ensuring thorough mixing, helping to eliminate unnecessary stirring time and improving production efficiency. Furthermore, the method is simple and rapid, making it easy to promote and implement. The prepared composite nanoparticles not only act as stabilizers to improve the efficiency of zein loading with curcumin, but also serve as target heads, specifically enhancing the drug's macrophage targeting, through physical cross-linking to the cationic zein surface via electrostatic adsorption. BRIEF DESCRIPTION OF THE DRAWINGS
[0037] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for use in the embodiments. It should be understood that the following drawings only illustrate certain embodiments of the present invention and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other relevant drawings can be obtained based on these drawings without paying any creative work.
[0038] Figure 1 A schematic diagram of the overall structure of a mixing device provided in an embodiment of the present invention;
[0039] Figure 2 Schematic diagram of the coordination of the drive components;
[0040] Figure 3 This is a schematic diagram of the coordination of the stirring shaft, reference seat, fixed seat and transmission wheel;
[0041] Figure 4 Schematic diagram of the internal structure of the fixed seat.
[0042] Description of reference numerals:
[0043] Mixing chamber 100; stirring shaft 200; stirring member 210; first extension rod 220; fixing base 230; mounting groove 231; transparent window 232; baffle 233; first end 233a; second end 233b; driving assembly 240; second extension rod 241; transmission wheel 242; reference base 243; annular flange 244; transmission shaft 245; turntable 250; visual assembly 300; driver 400. DETAILED DESCRIPTION
[0044] To make the objectives, technical solutions, and advantages of the embodiments of the present invention more clear, the technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Generally, the components of the embodiments of the present invention described and shown in the drawings herein can be arranged and designed in various different configurations.
[0045] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the invention as claimed, but rather merely represents selected embodiments of the present invention. All other embodiments derived by persons of ordinary skill in the art based on the embodiments of the present invention without creative effort are intended to fall within the scope of protection of the present invention.
[0046] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, it does not need to be further defined or explained in subsequent drawings.
[0047] The terms “first”, “second”, etc. are only used for distinguishing descriptions and should not be understood as indicating or implying relative importance.
[0048] Furthermore, the terms "parallel" and "perpendicular" do not necessarily mean that the components must be absolutely parallel or perpendicular, but rather that they can be slightly tilted. For example, "parallel" simply means that the direction is more parallel than "perpendicular," not that the structure must be completely parallel, but rather that it can be slightly tilted.
[0049] In the description of the present invention, it should also be noted that, unless otherwise expressly specified or limited, the terms "disposed," "installed," and "connected" should be understood broadly. For example, they may refer to fixed connections, detachable connections, or integral connections; they may refer to direct connections, indirect connections through an intermediate medium, or internal connections between two components. Those skilled in the art will understand the specific meanings of the above terms in the present invention based on the specific circumstances.
[0050] In order to overcome the shortcomings of the existing technology, please refer to Figures 1-4This embodiment provides a mixing device, which includes: a mixing chamber 100, a stirring shaft 200, a stirring member 210, a first extension rod 220, a fixing seat 230, a baffle 233, a driving component 240, a visual component 300 and a processor (not shown in the figure).
[0051] The stirring shaft 200 is disposed along the depth direction of the mixing bin 100 and is driven by a driver 400 .
[0052] The stirring member 210 is connected to the stirring shaft 200 and is used to stir the mixed phase. The stirring member 210 can be a stirring rod, but is not limited thereto.
[0053] The first extension rod 220 is fixedly connected to the stirring shaft 200 and is disposed along the radial direction of the stirring shaft 200 .
[0054] The fixing seat 230 is cylindrical and fixedly connected to the first extension rod 220 . The central axis of the fixing seat 230 is parallel to the central axis of the stirring shaft 200 .
[0055] The baffle 233 is arc-shaped, and the central axis of the cylindrical surface corresponding to the baffle 233 is parallel to the central axis of the fixing base 230. The baffle 233 is arranged near the side wall of the fixing base 230 and along the circumference of the fixing base 230. The baffle 233 has a first end 233a and a second end 233b opposite each other. The distance between the first end 233a and the fixing base 230 is greater than the distance between the second end 233b and the fixing base 230. In other words, the distance between the baffle 233 and the fixing base 230 gradually decreases from the first end 233a to the second end 233b.
[0056] The blocking piece 233 is driven by the driving assembly 240 so that the blocking piece 233 can rotate along the circumference of the fixing seat 230. During the rotation of the blocking piece 233, the first end 233a is located in front of the second end 233b along the rotation direction of the blocking piece 233.
[0057] The blocking piece 233 is made of a light-proof material.
[0058] The side wall of the fixing base 230 is provided with a mounting groove 231, which is arranged along the radial direction of the fixing base 230. The visual component 300 is mounted in the mounting groove 231, and the opening of the mounting groove 231 is closed by a transparent window 232. The visual component 300 includes a lens and a light source for fill light.
[0059] The visual component 300 is electrically connected to the processor, and the processor is used to determine whether solute particles exist based on the image data collected by the visual component 300, and then determine whether the solute particles are fully dissolved.
[0060] During the mixing process, the stirring shaft 200 drives the stirring member 210 to move, and the stirring member 210 directly stirs the mixed phase. At the same time, the stirring shaft 200 also synchronously drives the first extension rod 220 to rotate. During the rotation of the first extension rod 220, the driving assembly 240 drives the blocking piece 233 to move along the circumference of the fixing base 230.
[0061] On the one hand, the baffle 233 can enhance the stirring effect. On the other hand, during the rotation process, the baffle 233 can also guide the mixed phase around the fixed base 230 to the side wall of the fixed base 230. When the baffle 233 moves to the transparent window 232, the baffle 233 can serve as a light-blocking backplane, so that the light source of the visual component 300 can fully illuminate the mixed phase between the baffle 233 and the transparent window 232, thereby facilitating the lens of the visual component 300 to collect image data at this location.
[0062] The processor performs image analysis based on the image data. If solute particles can still be identified in the image data, it means that the solute has not yet fully dissolved. If no solute particles are identified within a certain period of time, it means that the solute has achieved a good dissolution effect. This allows for more intuitive and accurate control of the actual dissolution process, thereby facilitating more reasonable management and control of the mixing time.
[0063] In general, the mixing device provided in this embodiment can control the actual stirring process more intuitively and accurately, facilitate more reasonable determination of the stirring time, and effectively avoid excessive stirring on the basis of ensuring sufficient mixing, thereby helping to avoid unnecessary stirring time and improving production efficiency.
[0064] It should be noted that the “solute particles” in the present application may be solid particles or liquid particles (droplets).
[0065] In this embodiment, the processor may also use the image data collected by the visual component 300 to analyze the impurity particles. By analyzing whether the impurity particles exist, it may be determined whether the purity of the mixed phase is qualified.
[0066] Furthermore, the driving assembly 240 includes a second extension rod 241 , a transmission wheel 242 and a reference seat 243 .
[0067] The base 243 is fixedly connected to the inner bottom wall of the mixing chamber 100, and the bottom end of the stirring shaft 200 is rotatably engaged with the base 243. The base 243 has an annular flange 244, which is coaxially arranged with the stirring shaft 200 and has an outer gear ring.
[0068] The second extension rod 241 is fixedly connected to the stirring shaft 200 and is disposed along the radial direction of the stirring shaft 200 . The second extension rod 241 is parallel to and arranged in parallel with the first extension rod 220 .
[0069] The transmission wheel 242 is rotatably coupled to the second extension rod 241 , and a rotation axis of the transmission wheel 242 is parallel to the central axis of the stirring shaft 200 .
[0070] The wheel surface of the transmission wheel 242 has an outer ring gear, and the transmission wheel 242 is engaged with the annular flange 244.
[0071] The transmission wheel 242 is in transmission cooperation with the blocking piece 233 .
[0072] When the stirring shaft 200 rotates, it can drive the transmission wheel 242 to move relative to the annular flange 244 along the circumference of the annular flange 244. Since the annular flange 244 is fixed and the transmission wheel 242 can rotate relative to the second extension rod 241, the transmission wheel 242 can rotate during this process, thereby driving the baffle 233 to rotate along the circumference of the fixed base 230.
[0073] In this embodiment, there are a plurality of fixing bases 230 along the length direction of the first extension rod 220 , and each fixing base 230 is correspondingly provided with a blocking piece 233 .
[0074] Along the length direction of the second extension rod 241, there are multiple transmission wheels 242, and each blocking piece 233 is correspondingly provided with a transmission wheel 242. The transmission wheels 242 are meshed with each other in sequence, and the transmission wheel 242 located at the end of the second extension rod 241 near the stirring shaft 200 is meshed with the annular flange 244.
[0075] Through this design, the transmission wheel 242 can not only serve as a transmission medium to realize power transmission in sequence and enable each baffle 233 to rotate smoothly, but also the meshing transmission wheels 242 and the meshing transmission wheels 242 and the annular flange 244 can crush the solute particles, thereby promoting faster and more complete dissolution of the solute and helping to shorten the time required for stirring.
[0076] The second extension rod 241 is located on a side of the first extension rod 220 close to the bottom of the mixing chamber 100 .
[0077] Furthermore, the driving assembly 240 also includes a turntable 250 .
[0078] The transmission wheel 242 is coaxially disposed with the fixing base 230 .
[0079] A rotating disk 250 is rotatably coupled to the side of the fixing base 230 close to the transmission wheel 242 , and the rotation axis of the rotating disk 250 coincides with the central axis of the fixing base 230 . The blocking piece 233 is fixedly connected to the rotating disk 250 .
[0080] The transmission wheel 242 is coaxially fixedly connected to a transmission shaft 245 , and the transmission shaft 245 is fixedly connected to the turntable 250 .
[0081] The turntable 250 can effectively alleviate the flow intensity around the fixing base 230 in the axial direction thereof, thereby making it easier for the visual component 300 to collect image data.
[0082] Optionally, the transparent window 232 may be a convex lens, so that the image can be further magnified with the help of the transparent window 232, which is more conducive to analyzing whether solute particles and impurity particles still exist.
[0083] This embodiment also provides a method for preparing hyaluronic acid-zein-curcumin composite nanoparticles, which comprises the following steps:
[0084] S1. Using the above-mentioned mixing device, completely dissolve the hyaluronic acid powder in distilled water to obtain a hyaluronic acid solution. During the dissolution process, the mixing device is used to determine whether the hyaluronic acid powder is completely dissolved, thereby more reasonably controlling the mixing condition.
[0085] S2. Dissolve zein and curcumin in 70% ethanol using the mixing device to obtain a zein-curcumin-ethanol solution. During the dissolution process, the mixing device is used to determine whether the zein and curcumin are fully dissolved, thereby more reasonably controlling the mixing condition.
[0086] S3. While stirring, drop the zein-curcumin-ethanol solution into the hyaluronic acid solution, and stir to form a hyaluronic acid-zein solution encapsulating curcumin.
[0087] S4. Evaporating the ethanol in the hyaluronic acid-zein solution encapsulating curcumin, centrifuging the solution at room temperature, and washing the solution with distilled water to obtain hyaluronic acid-zein-curcumin composite nanoparticles.
[0088] Optionally, in step S1, the dosage of hyaluronic acid powder and distilled water is: 0.1-0.2 mg hyaluronic acid powder / 1 ml distilled water.
[0089] Optionally, in step S2, the dosage of curcumin, zein and 70% ethanol is in the following ratio: 2 mg curcumin / 20-30 mg zein / 1 ml-3 ml 70% ethanol.
[0090] Optionally, in step S3, the stirring rate is 600 rpm, the stirring time is 3 h, and the stirring temperature is 50°C.
[0091] Optionally, in step S4, the centrifugal speed is 12000 rpm.
[0092] Optionally, in step S4, the number of times of washing with distilled water is 3 times.
[0093] In summary, the mixing device provided in the embodiment of the present invention can control the actual stirring process more intuitively and accurately, facilitate more reasonable determination of the stirring time, and effectively avoid excessive stirring on the basis of ensuring sufficient mixing, which helps to avoid unnecessary stirring time and improve production efficiency.
[0094] The method for preparing hyaluronic acid-zein-curcumin composite nanoparticles provided in the embodiments of the present invention effectively avoids excessive stirring while ensuring thorough mixing, helping to eliminate unnecessary stirring time and improving production efficiency. Furthermore, the method is simple and rapid, making it easy to promote and implement. The prepared composite nanoparticles not only act as stabilizers to improve the efficiency of zein loading with curcumin, but also serve as target heads, specifically enhancing the drug's macrophage targeting, through physical cross-linking to the cationic zein surface via electrostatic adsorption.
[0095] The foregoing description is merely a preferred embodiment of the present invention and is not intended to limit the present invention. Those skilled in the art will readily appreciate that various modifications and variations of the present invention are possible. Any modifications, equivalent substitutions, or improvements made within the spirit and principles of the present invention shall be included within the scope of protection of the present invention.
Claims
1. A mixing device, characterized in that: include: A mixing chamber, a stirring shaft, a stirring member, a first extension rod, a fixing seat, a baffle, a driving assembly, a visual assembly, and a processor; The stirring shaft is arranged along the depth direction of the mixing chamber and is driven by a driver; the stirring member is connected to the stirring shaft; the first extension rod is connected to the stirring shaft and is arranged along the radial direction of the stirring shaft; The fixing seat is cylindrical, the fixing seat is fixedly connected to the first extension rod, and the central axis of the fixing seat is arranged parallel to the central axis of the stirring shaft; The baffle is arc-shaped, and the central axis of the cylindrical surface corresponding to the baffle is arranged parallel to the central axis of the fixing base; the baffle is arranged close to the side wall of the fixing base and arranged along the circumference of the fixing base, the baffle has a first end and a second end opposite to each other, and the distance between the first end and the fixing base is greater than the distance between the second end and the fixing base; the baffle is driven by the driving assembly so that the baffle can rotate along the circumference of the fixing base, and along the rotation direction of the baffle, the first end is located in front of the second end; the baffle is made of opaque material; The side wall of the fixing seat is provided with a mounting groove, the mounting groove is arranged along the radial direction of the fixing seat, the visual component is installed in the mounting groove, and the mouth of the mounting groove is closed by a transparent window; The visual component is electrically connected to the processor, and the processor is used to determine whether solute particles exist based on image data collected by the visual component, and then determine whether the solute is fully dissolved.
2. The mixing device according to claim 1, characterized in that The processor is further configured to determine whether foreign particles exist based on the image data collected by the visual component, and further determine whether the mixed phase is qualified.
3. The mixing device according to claim 1, characterized in that The driving assembly includes: a second extension rod, a transmission wheel and a reference seat; The reference seat is fixedly connected to the inner bottom wall of the mixing bin, and the bottom end of the stirring shaft is rotatably engaged with the reference seat; the reference seat has an annular flange, which is coaxially arranged with the stirring shaft, and the annular flange has an outer gear ring; The second extension rod is fixedly connected to the stirring shaft and is arranged along the radial direction of the stirring shaft. The second extension rod is parallel to and arranged in parallel with the first extension rod. The transmission wheel is rotatably engaged with the second extension rod, and the rotation axis of the transmission wheel is arranged parallel to the central axis of the stirring shaft. The wheel surface of the transmission wheel has an outer ring gear, and the transmission wheel is engaged with the annular flange. The transmission wheel is in transmission cooperation with the blocking piece.
4. The mixing device according to claim 3, characterized in that Along the length direction of the first extension rod, there are a plurality of fixing seats, and each fixing seat is correspondingly provided with a blocking piece; Along the length direction of the second extension rod, there are multiple transmission wheels, and each baffle is correspondingly provided with a transmission wheel; the transmission wheels are engaged with each other in sequence, and the transmission wheel located at one end of the second extension rod close to the stirring shaft is engaged with the annular flange.
5. The mixing device according to claim 3, characterized in that The drive assembly further includes: a turntable; The transmission wheel is coaxially arranged with the fixing seat; A turntable is rotatably coupled to a side of the fixing seat close to the transmission wheel, and the rotation axis of the turntable coincides with the central axis of the fixing seat; the baffle is fixedly connected to the turntable; The transmission wheel is coaxially fixedly connected with a transmission shaft, and the transmission shaft is fixedly connected to the turntable.
6. The mixing device according to claim 1, characterized in that The transparent window is made of a convex lens.
7. A method for preparing hyaluronic acid-zein-curcumin composite nanoparticles, characterized in that: The steps include: S1. Using the mixing device according to any one of claims 1 to 6, completely dissolving hyaluronic acid powder in distilled water to obtain a hyaluronic acid solution; S2. Dissolving zein and curcumin in 70% ethanol using the mixing device according to any one of claims 1 to 6 to obtain a zein-curcumin-ethanol solution; S3. Under stirring, adding the zein-curcumin-ethanol solution dropwise into the hyaluronic acid solution, and stirring to form a hyaluronic acid-zein solution encapsulating curcumin; S4, evaporating the ethanol in the hyaluronic acid-zein solution encapsulating curcumin, then centrifuging at room temperature, and washing with distilled water to obtain hyaluronic acid-zein-curcumin composite nanoparticles.