Handheld nondestructive detector suction head and handheld nondestructive detector

Abstract

The invention discloses a handheld non-destructive detector suction head and a handheld non-destructive detector, and belongs to the technical field of experimental detection consumables and equipment.The suction head comprises a superfine circular tube, a flat storage area, an insertion cylinder and a filter, the superfine circular tube is located at the bottom of the flat storage area, the flat storage area is communicated with the superfine circular tube, and the insertion cylinder is connected with the filter. And the inserting cylinder is located at the top of the flat storage area and communicates with the flat storage area, and the filter is located at an opening in the tail end of the ultra-thin circular pipe. According to the invention, non-contact absorbance detection of a liquid sample is realized, and pollution is avoided; sample recovery after detection is supported, and the experiment cost is reduced; therefore, the method is especially suitable for detection of precious biological samples (such as DNA and antibodies).

Description

Technical Field

[0001] The invention belongs to the technical field of experimental detection consumables and detectors, and in particular relates to a handheld non-destructive detector suction head and a handheld non-destructive detector. Background Art

[0002] Handheld NDT tips are primarily used in various laboratories, working with handheld NDTs for quantitative liquid pipetting. Experiments in fields such as life sciences, chemistry, and medicine often require precise pipetting of small or trace amounts of liquid, placing high demands on the accuracy, sealing, and other performance characteristics of handheld NDT tips. Handheld NDTs primarily operate based on the air displacement or positive displacement method. The air displacement method utilizes a spring to retract and expand a piston, actuating the suction and discharge of liquids by varying the air pressure within the tip. This method is suitable for most common liquids.

[0003] In the existing testing of liquids, the liquid is generally adsorbed by a straw and then transferred to the testing equipment for testing. This requires at least two steps to test the liquid, and the testing operation is cumbersome and troublesome.

[0004] Furthermore, traditional pipette tip consumables are only used for liquid transfer in liquid absorbance testing, which leads to the following problems:

[0005] 1. The liquid to be tested is in direct contact with the testing equipment, resulting in sample contamination;

[0006] 2. The samples cannot be recovered after testing, resulting in waste of precious samples;

[0007] 3. Conventional pipette tips have a longer optical path and require more sample volume;

[0008] 4. Ordinary pipette tip consumables cannot be used directly for testing and require additional sample transfer. Summary of the Invention

[0009] The embodiments of the present invention provide a handheld non-destructive detector nozzle and a handheld non-destructive detector to solve the problems in the prior art.

[0010] An embodiment of the present invention adopts the following technical solution: a handheld non-destructive detector suction head, comprising a suction head, wherein the suction head includes an extremely fine circular tube, a flat storage area, a plug-in cylinder, and a filter, wherein the extremely fine circular tube is located at the bottom of the flat storage area, and the flat storage area is connected to the extremely fine circular tube; the plug-in cylinder is located at the top of the flat storage area, and the plug-in cylinder is connected to the flat storage area; and the filter is located at the end opening of the extremely fine circular tube.

[0011] According to a further technical solution, the thickness of the flat storage area is 1.2 mm.

[0012] According to a further technical solution, the outer side wall of the flat storage area is provided with a volume scale.

[0013] According to a further technical solution, the extremely thin round tube, the flat storage area and the plug-in cylinder are all made of transparent quartz or polystyrene (PS).

[0014] According to a further technical solution, the filter is a 0.22 μm filter.

[0015] A handheld nondestructive detector comprises a handheld nondestructive detector body for adsorbing and recovering samples, a housing, and a light-shielding shield. The handheld nondestructive detector body is located inside the housing, and the light-shielding shield is located at the bottom of the housing. A screen is provided on the housing, and a light source and a detector are provided on both side walls of the light-shielding shield, respectively. The light source and the detector are symmetrically arranged. A battery is provided within the housing for powering the handheld nondestructive detector body, screen, light source, and detector. The screen is electrically connected to the handheld nondestructive detector body, light source, and detector, and a control circuit board is provided on the screen.

[0016] According to a further technical solution, the light source and the detector correspond to the flat storage area to form a light path.

[0017] A further technical solution is that the handheld non-destructive detector body includes an adsorption head, an adsorption cylinder, a stepper motor, a screw and a piston, the adsorption cylinder is located inside the shell, the adsorption head is located below the adsorption cylinder and is connected to the adsorption cylinder, the stepper motor is located on the upper side of the adsorption cylinder, the screw is connected to the main shaft of the stepper motor, the piston is threadedly connected to the screw, and the piston moves up and down in the adsorption cylinder to adsorb and recover the sample.

[0018] According to a further technical solution, the suction tip is sealed and plugged into the adsorption head.

[0019] According to a further technical solution, a detachable light-shielding cover is provided on the light-shielding shield.

[0020] The at least one technical solution adopted in the embodiment of the present invention can achieve the following beneficial effects:

[0021] Pollution-free testing: Liquid only contacts the inside of the consumables, avoiding equipment contamination. Suitable for testing precious biological samples (such as DNA and antibodies).

[0022] Sample recovery: After testing, 100% of the sample is recovered into the original tube, reducing experimental costs. It is especially suitable for scarce samples (such as clinical puncture fluid).

[0023] Micro-volume detection: The optical path length of the flat storage area is ≤1.2mm, and the sample volume is only 1 / 5-1 / 10 of that of traditional cuvettes.

[0024] Detection accuracy: Quartz or PS materials have high light transmittance uniformity, and the accuracy can reach: ±1% (0-3Abs) @405nm;

[0025] ±2% (3-4Abs)@405nm.

[0026] Accuracy: CV < 0.2% (0-3 Abs), CV < 1.0% (3-4 Abs) @ 405 nm.

[0027] Convenience of operation: This consumable can be used directly to complete the entire process of aspiration-detection-recovery without transferring samples, improving efficiency by more than 30%. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] The drawings described herein are used to provide a further understanding of the present invention and constitute a part of the present invention. The exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation of the present invention. In the drawings:

[0029] Figure 1 This is a schematic diagram of the handheld non-destructive detector before testing in the present invention;

[0030] Figure 2 This is a schematic diagram of the handheld non-destructive detector during testing in the present invention;

[0031] Figure 3 For the present invention Figure 1 ;

[0032] Figure 4 for Figure 3 Sectional view along line AA;

[0033] Figure 5 For the present invention Figure 2 ;

[0034] Figure 6 for Figure 5 Cross-sectional view along line BB;

[0035] Figure 7 It is a schematic diagram of the three-dimensional structure of the present invention;

[0036] Figure 8 Schematic diagram of the three-dimensional structure of the handheld non-destructive detector body of the present invention;

[0037] Figure 9 Schematic diagram of the three-dimensional structure of the suction head of the present invention;

[0038] Reference numerals:

[0039] Suction tip 1, ultra-thin round tube 2, flat storage area 3, plug-in cylinder 4, handheld non-destructive detector body 5, suction head 6, suction cylinder 7, stepper motor 8, screw 9, piston 10, housing 11, light-shielding cover 12, screen 13, light source 14, detector 15, battery 16, light-shielding cover 17, control circuit board 18. DETAILED DESCRIPTION

[0040] To make the objectives, technical solutions, and advantages of the present invention more clear, the technical solutions of the present invention will be clearly and completely described below in conjunction with specific embodiments of the present invention and corresponding drawings. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0041] The following describes in detail a technical solution of a handheld non-destructive detector nozzle and a handheld non-destructive detector according to various embodiments of the present invention in conjunction with the accompanying drawings.

[0042] Reference Figures 1 to 9 As shown, an embodiment of the present invention provides a handheld non-destructive tester pipette tip, comprising a pipette tip 1, comprising an ultra-fine circular tube 2, a flat storage area 3, a plug-in cylinder 4, and a filter. The ultra-fine circular tube 2 is located at the bottom of the flat storage area 3, communicating with the flat storage area 3. The plug-in cylinder 4 is located at the top of the flat storage area 3, communicating with the flat storage area 3. The filter is located at the end opening of the ultra-fine circular tube 2. The ultra-fine circular tube 2 can accurately aspirate trace amounts of liquid (e.g., 5 μL) to reduce residue.

[0043] It should be noted that the sample tested is for tumor markers (such as ctDNA), and the sample consumables aspirate 5 μL of sample.

[0044] In this embodiment, the thickness of the flat storage area 3 is 1.2 mm, forming an extremely small optical path (≤1.2 mm), and the sample usage is only 1 / 5-1 / 10 of that of a traditional cuvette, or even lower.

[0045] In this embodiment, the outer side wall of the flat storage area 3 is provided with a volume scale, and the surface is marked with volume scales (such as 0 μL, 2 μL, 5 μL) to facilitate accurate measurement.

[0046] In this embodiment, the ultra-thin round tube 2, the flat storage area 3 and the plug-in cylinder 4 are all made of transparent polystyrene (PS) material, and the light transmission range covers 200-900nm, meeting the requirements of ultraviolet-visible-near infrared spectrum detection.

[0047] In this embodiment, the filter is a 0.22 μm filter to ensure one-way flow of the liquid. The filter can block the direct contact path between the liquid and the equipment / detection device.

[0048] A handheld nondestructive detector includes a handheld nondestructive detector body 5 for adsorbing and recovering samples, a housing 11, and a light-shielding shield 12. The handheld nondestructive detector body 5 is located inside the housing 11, and the light-shielding shield 12 is located at the bottom of the housing 11. A screen 13 is provided on the housing 11. A light source 14 and a detector 15 are provided on both sidewalls of the interior of the light-shielding shield 12, respectively. The light source 14 and the detector 15 are symmetrically arranged. A battery 16 is provided within the housing 11 for powering the handheld nondestructive detector body 5, screen 13, light source 14, and detector 15. The screen 13 is electrically connected to the handheld nondestructive detector body 5, light source 14, and detector 15, and a control circuit board 18 is provided on the screen 13. The control circuit board 18 can control the stepping motor 8, light source 14, and detector 15.

[0049] In this embodiment, the light source 14 and detector 15 correspond to the flat storage area 3, forming a light path; the light source 14 and detector 15 detect the sample within the flat storage area 3. The absorbance calculation process: Light from the light source 14 transmits light through the liquid (the sample being tested). The light is collected by the detector 15 and converted into an electrical signal. The electrical signal is then converted into a digital signal by the mainboard. The mainboard then calculates the absorbance based on the digital signal using the following calculation method: absorbance = -log10 (light intensity transmitted through the reagent / blank light intensity). The absorbance is then displayed directly on the screen 13.

[0050] In this embodiment, the handheld non-destructive detector body 5 includes an adsorption head 6, an adsorption cylinder 7, a stepper motor 8, a screw 9 and a piston 10. The adsorption cylinder 7 is located inside the shell 11, the adsorption head 6 is located below the adsorption cylinder 7 and is connected to the adsorption cylinder 7, the stepper motor 8 is located on the upper side of the adsorption cylinder 7, the screw 9 is connected to the main shaft of the stepper motor 8, and the piston 10 is threadedly connected to the screw 9. The piston 10 moves up and down in the adsorption cylinder 7 to adsorb and recover the sample.

[0051] During the sample adsorption process, by clicking the control button on the screen 13, the stepper motor 8 can be controlled to drive the screw 9 to rotate, thereby driving the piston 10 to move upward in the adsorption cylinder 7, so that the sample can be moved upward through the suction head 1 and adsorbed into the flat storage area 3, so that the sample can be subsequently detected non-contact by the light source 14 and the detector 15;

[0052] After the sample is tested, the stepper motor 8 drives the screw 9 to rotate, thereby driving the piston 10 to move downward in the adsorption cylinder 7, so that the sample returns from the flat storage area 3 to the original sample tube, thereby realizing the recovery of the sample.

[0053] In this embodiment, the suction tip 1 is sealed and plugged into the adsorption head 6. When performing a test, the suction tip 1 can be installed on the adsorption head 6 to adsorb the sample for testing. When not testing, the suction tip 1 can be removed from the adsorption head 6 for cleaning and disinfection.

[0054] In this embodiment, a detachable light-shielding cover 17 is provided on the light-shielding cover 12 to prevent external light from affecting the accuracy of the detection during the detection process.

[0055] Beneficial effects of the present invention:

[0056] Pollution-free testing: Liquid only contacts the inside of the consumables and the filter, avoiding equipment contamination. Suitable for testing precious biological samples (such as DNA and antibodies).

[0057] Sample recovery: After testing, 100% of the sample is recovered into the original tube, reducing experimental costs. It is especially suitable for scarce samples (such as clinical puncture fluid).

[0058] Micro-detection: Flat storage area 3 optical path ≤ 1.2mm, sample usage is only 1 / 5-1 / 10 of traditional methods, or even lower.

[0059] Detection accuracy: Quartz or PS materials have high light transmittance uniformity, and the accuracy can reach: ±1% (0-3Abs) @405nm;

[0060] ±2% (3-4Abs)@405nm.

[0061] Accuracy: CV < 0.2% (0-3 Abs), CV < 1.0% (3-4 Abs) @ 405 nm.

[0062] Convenience of operation: This consumable can be used directly to complete the entire process of aspiration-detection-recovery without transferring samples, improving efficiency by more than 30%.

[0063] The foregoing is merely an embodiment of the present invention and is not intended to limit the present invention. It will be apparent to those skilled in the art that various modifications and variations of the present invention are possible. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention are intended to be included within the scope of the claims of the present invention.

Claims

1. A handheld non-destructive detector nozzle, characterized in that: The suction head (1) comprises an extremely thin round tube (2), a flat storage area (3), a plug-in cylinder (4) and a filter. The very fine round tube (2) is located at the bottom of the flat storage area (3), and the flat storage area (3) and the very fine round tube (2) are connected. The plug-in cylinder (4) is located on the top of the flat storage area (3), and the plug-in cylinder (4) is connected to the flat storage area (3). The filter is located at the end opening of the very thin circular tube (2).

2. The handheld non-destructive detector nozzle according to claim 1, characterized in that: The thickness of the flat storage area (3) is 1.2 mm.

3. A handheld non-destructive detector nozzle according to claim 1 or 2, characterized in that: The outer side wall of the flat storage area (3) is provided with a marked volume scale.

4. The handheld non-destructive detector nozzle according to claim 1, characterized in that: The extremely thin circular tube (2), the flat storage area (3) and the plug-in cylinder (4) are all made of transparent polystyrene (PS) material.

5. The handheld non-destructive detector nozzle according to claim 1, characterized in that: The filter used is a 0.22 μm filter.

6. A handheld nondestructive detector comprising a handheld nondestructive detector tip as claimed in claim 1, characterized in that: The invention comprises a handheld non-destructive detector body (5) for adsorbing and recovering samples, a housing (11) and a light-proof shield (12). The handheld non-destructive detector body (5) is located inside the housing (11), the light-shielding shield (12) is located at the bottom of the housing (11), and a screen (13) is provided on the housing (11). A light source (14) and a detector (15) are respectively provided on both side walls of the interior of the light-shielding shield (12), and the light source (14) and the detector (15) are symmetrically arranged. The housing (11) is provided with a battery (16) for supplying power to the handheld nondestructive detector body (5), the screen (13), the light source (14) and the detector (15). The screen (13) is electrically connected to the handheld non-destructive detector body (5), the light source (14) and the detector (15), and a control circuit board (18) is provided on the screen (13).

7. The handheld nondestructive detector according to claim 6, characterized in that: The light source (14) and the detector (15) correspond to the flat storage area (3) to form a light path.

8. The handheld nondestructive detector according to claim 6, characterized in that: The handheld non-destructive detector body (5) comprises an adsorption head (6), an adsorption cylinder (7), a stepping motor (8), a screw (9) and a piston (10); the adsorption cylinder (7) is located inside a housing (11); the adsorption head (6) is located below the adsorption cylinder (7) and is connected to the adsorption cylinder (7); the stepping motor (8) is located on the upper side of the adsorption cylinder (7); the screw (9) is connected to the main shaft of the stepping motor (8); the piston (10) is threadedly connected to the screw (9); and the piston (10) moves up and down in the adsorption cylinder (7) to adsorb and recover the sample.

9. The handheld nondestructive detector according to claim 8, characterized in that: The suction head (1) is sealed and plugged into the adsorption head (6).

10. The handheld nondestructive detector according to claim 6, characterized in that: The light-shielding shield (12) is provided with a detachable light-shielding shield (17).

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