Lemon and mint flavored refreshing anti-fatigue chewing gum containing natural active ingredients

Abstract

The invention relates to lemon and mint flavored refreshing anti-fatigue chewing gum containing natural active ingredients, and belongs to the technical field of food. Through synergistic compounding of the rhodiola rosea extract, the sea-buckthorn extract, caffeine and the American ginseng extract, central nervous excitation and mitochondrial energy metabolism pathways are synchronously activated in the oral chewing process, and the dual effects of instant refreshing and long-acting fatigue resistance are achieved. Wherein the caffeine blocks an adenosine receptor to realize rapid wakeup, the rhodiola rosea and the American ginseng jointly enhance cell energy synthesis, the sea-buckthorn component protects neurons from oxidative damage, and ginseng and astragalus membranaceus extracts can be selected to improve cerebral blood flow supply. According to the product, lemon and mint flavor is adopted for optimizing experience, all components are selected from a medicinal and edible catalog, the stability of active substances is guaranteed through a fine processing technology, and finally, a functional food which is safe and independent and has instant refreshing and continuous anti-fatigue capabilities is formed.

Description

Technical Field

[0001] The invention relates to the technical field of food, in particular to a lemon-mint-flavored refreshing and anti-fatigue chewing gum containing natural active ingredients. Background Art

[0002] Technical bottlenecks of existing functional chewing gums: Currently available stimulating gums rely primarily on a single pathway of stimulation with high doses of caffeine (usually 0.2%-0.5%), which has three major drawbacks:

[0003] The duration of action is limited: it can only provide short-term nerve stimulation (about 30-60 minutes) and lacks the ability to continuously resist fatigue;

[0004] Significant side effects: long-term use can easily cause palpitations, dependence, and metabolic disorders;

[0005] Lack of optimized brain function: Unable to activate mitochondrial energy metabolism pathways or improve cerebral blood perfusion, making it difficult to cope with chronic fatigue syndrome.

[0006] Key obstacles to the application of natural ingredients Although natural active ingredients (such as ginseng and rhodiola) have been proven to have anti-fatigue potential, there are technical limitations: low bioavailability: traditional oral dosage forms (capsules, tablets) are difficult to be quickly absorbed through the oral mucosa; insufficient multi-pathway synergy: a single ingredient cannot simultaneously achieve neurotransmitter regulation (instantaneous awakening) and mitochondrial function optimization (long-term anti-fatigue).

[0007] Therefore need a kind of lemon mint flavor refreshing anti-fatigue chewing gum containing natural active ingredient to solve above-mentioned problem. Summary of the Invention

[0008] In order to solve the problems of the prior art, the present invention provides a lemon mint flavored refreshing and anti-fatigue chewing gum containing natural active ingredients.

[0009] In order to solve the above technical problems, the present invention is achieved through the following technical solutions:

[0010] In a first aspect, a lemon-mint flavored refreshing and anti-fatigue chewing gum containing natural active ingredients comprises a gum base, a sweetener, and an active ingredient mixture, wherein the active ingredient mixture includes rhodiola rosea extract, sea buckthorn extract, caffeine, and American ginseng extract, wherein the active ingredient mixture is configured to provide a refreshing effect by stimulating the central nervous system.

[0011] In this application, its core component, caffeine, quickly activates the dopaminergic neural pathway by blocking adenosine A2A receptors, significantly improving cortical wakefulness within 5-10 minutes; it synergistically amplifies the cAMP-PKA signaling pathway, enhancing the power of EEG beta waves by 50%. At the sustained effect level, American ginseng saponins and salidroside jointly activate the AMPK / PGC-1α pathway, promote mitochondrial biogenesis and increase cytochrome C oxidase activity. Continuous use for 7 days can increase ATP production efficiency by 35% and accelerate blood lactate clearance by 2.1 times; seabuckthorn flavonoids induce superoxide dismutase expression through the Nrf2 / ARE pathway, reducing cortisol-induced hippocampal neuron apoptosis by 67%, forming an antioxidant barrier; the newly added astragaloside IV synergistically enhances cerebral vascular eNOS synthesis, increasing cerebral blood flow by 40% (up to 58±6mL / 100g / min) after 20 minutes of chewing, continuously optimizing brain oxygen supply. All active ingredients strictly follow the catalog of medicinal and edible ingredients and the national standard (GB17399-2016), and the acute toxicity test LD 50 >15g / kg, providing dual time-effectiveness (instant alertness / long-lasting anti-fatigue) while ensuring physiological safety; natural monk fruit extract (mogroside) optimizes system performance through a dual synergistic mechanism: first, inhibiting α-glucosidase activity to reduce postprandial blood sugar fluctuations by 21%, eliminating the energy metabolism fault caused by a sudden drop in blood sugar; second, activating the Nrf2 pathway and synergizing with seabuckthorn flavonoids to enhance total antioxidant capacity (T-AOC) by 32%, and inhibiting NF-κB-mediated neuroinflammation (TNF-α in the hippocampus decreased by 38%), providing an anti-inflammatory protective barrier for caffeine's dopamine activation.

[0012] In a specific embodiment of the first aspect, the active ingredient mixture further comprises an additional ingredient that excites the central nervous system, and the additional ingredient is selected from at least one of a ginseng extract and an astragalus extract.

[0013] In a specific embodiment of the first aspect, the additional ingredients that excite the central nervous system include ginseng extract and astragalus extract to enhance physical strength and anti-fatigue effects.

[0014] In a specific embodiment of the first aspect, the chewing gum includes lemon mint flavoring, and the content of the lemon mint flavoring is 0.1% to 1.0% of the total mass of the chewing gum.

[0015] In a specific embodiment of the first aspect, the sweetener is natural monk fruit extract, i.e., mogroside, the content of which accounts for 0.02%-0.5% of the total mass of the chewing gum, and sorbitol also accounts for 40.5%-40.92% of the total mass of the chewing gum.

[0016] In a specific embodiment of the first aspect, the proportion of the active ingredient mixture satisfies the following range: Rhodiola rosea extract accounts for 1% to 5% of the total mass of the chewing gum, sea buckthorn extract accounts for 3% to 10%, caffeine accounts for 0.01% to 0.1%, and American ginseng extract accounts for 1% to 5%.

[0017] In a specific embodiment of the first aspect, all ingredients are from the "List of Substances that are Both Food and Medicine" published by the National Health Commission, and the chewing gum complies with GB17399-2016 "National Food Safety Standard Candy" and GB14758-2010 "Food Additive Caffeine Usage Requirements".

[0018] In a specific embodiment of the first aspect, the chewing gum further comprises auxiliary ingredients, wherein the auxiliary ingredients include at least one of B vitamins or electrolytes to improve nerve function.

[0019] In a second aspect, a method for preparing a lemon-mint flavored refreshing and anti-fatigue chewing gum containing natural active ingredients is provided, characterized in that the method comprises the following steps: heating the gum base to 40° C. to 60° C., mixing a sweetener and an active ingredient mixture, and adding a flavoring agent to form the gum.

[0020] In a third aspect, a method for using a lemon-mint flavored refreshing and anti-fatigue chewing gum containing natural active ingredients comprises releasing the active ingredients by chewing to provide a short-term refreshing effect within 10 minutes, and providing a long-term anti-fatigue effect after 14 days through continued use.

[0021] Synergistic effect of mogrosides in functional systems:

[0022] This product uses natural mogroside as the core sweetener (added at 0.02%-0.5%). Its value goes beyond traditional sweetening, achieving synergistic enhancement of throat moisturizing, voice protection, and nerve function through a triple mechanism:

[0023] Protective mechanism for the throat mucosa: Mogroside V in mogrosides, after being absorbed through the oral mucosa, selectively inhibits the activation of TRPV1 pain receptors in the throat (reduction rate up to 41%*), directly blocking the neurogenic inflammatory pathway and relieving vocal cord tension and dryness and itching.

[0024] Vocal cord anti-inflammatory and antioxidant barrier: synergistically activates the Nrf2 / ARE pathway with seabuckthorn flavonoids, increases the activity of SOD enzyme in the throat tissue, neutralizes the reactive oxygen species (ROS) produced by high-intensity voice use, and reduces the levels of inflammatory factors such as IL-6 in the vocal cord mucosa.

[0025] Neuro-metabolic linkage regulation: By inhibiting α-glucosidase, it delays blood sugar fluctuations and avoids the distraction caused by a sudden drop in blood sugar; it simultaneously reduces NF-κB-mediated brain inflammation and provides an anti-inflammatory base environment for caffeine's dopamine activation.

[0026] Deep synergy with the main function

[0027] Instantaneous effect optimization: Based on the cooling stimulation of lemon mint flavor, the monk fruit component promotes the sustained release of active ingredients by lowering the throat pain threshold and prolonging the comfortable chewing time by ≥40%.

[0028] Long-term anti-fatigue enhancement: blocks the vicious cycle of "throat discomfort to elevated cortisol to central fatigue". Continuous use for 14 days can increase salivary SIgA immunoglobulin and reduce the incidence of fatigue-related laryngitis in people who use their voice professionally.

[0029] The beneficial effects of the present invention are:

[0030] 1. Through the multi-target synergistic effect of the four active ingredients (Rhodiola rosea extract, sea buckthorn extract, caffeine, and American ginseng extract), it achieves a dual breakthrough in instantaneous refreshing and long-lasting anti-fatigue effects:

[0031] 5-10 minutes rapid awakening: Caffeine blocks adenosine A2A receptors, activates dopaminergic neural pathways, and significantly enhances cortical wakefulness through the cAMP-PKA signaling cascade. Within 30 seconds after chewing, the beta wave increases by 18.2±2.7% (p<0.01).

[0032] 14-day continuous anti-fatigue effect: American ginseng saponins and salidroside synergistically activate the AMPK / PGC-1α pathway, promote mitochondrial biogenesis, and simultaneously accelerate blood lactate clearance (the rate increases by 2.1 times); seabuckthorn flavonoids induce superoxide dismutase expression through the Nrf2 / ARE pathway, significantly inhibit cortisol-induced neuronal apoptosis, and build a neural antioxidant barrier.

[0033] 2. Double protection is achieved through brain function optimization based on medicinal and edible ingredients and industrial precision control:

[0034] Improved cerebral hemodynamics: Astragaloside IV enhances cerebral vascular eNOS synthesis. After 20 minutes of chewing, cerebral blood flow reaches 58±6mL / 100g / min, simultaneously optimizing cerebral oxygen metabolism and waste clearance.

[0035] Safety and efficacy verification: All ingredients comply with the "List of Substances that are Both Food and Drug", acute oral toxicity LD 50 >15g / kg; Continuous use for 14 days significantly improves cognitive ability and reduces physiological stress;

[0036] Breakthrough in process stability: Supercritical CO2 extraction technology retains ≥95% of seabuckthorn flavonoid activity, the two-step addition process of lemon mint flavor increases the flavor retention rate during shelf life by 32%, and the extrusion molding hardness is precisely controlled at 45-50N (determined by texture analyzer).

[0037] 3. Solve the shortcomings of traditional functional foods with low-dose, high-efficiency formulas:

[0038] Through the targeted complementarity of the quaternary active system, the caffeine dosage is only 0.01-0.1%, which is much lower than the single-ingredient refreshing products (conventional 0.2-0.5%).

[0039] Combining ginseng extract and astragalus extract to enhance physical strength and increase cerebral blood flow;

[0040] Adding B vitamins and electrolytes to assist nerve function, combined with lemon mint flavor (0.1-1.0%), enhances the user experience;

[0041] The finished product fully complies with the national standards GB17399-2016 and GB14758-2010, and has the triple advantages of rapid response (10 minutes), continuous anti-fatigue (14 days), and safety and non-dependence, filling the gap in industrial products with natural ingredients and dual-time reminders for brain function. DETAILED DESCRIPTION

[0042] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0043] A refreshing and anti-fatigue chewing gum with lemon mint flavor containing natural active ingredients.

[0044] 1. Preparation of basic raw materials

[0045] This embodiment requires the pre-preparation of the core active ingredient extract: the dried rhizome of Rhodiola rosea is crushed through a 60-mesh sieve, and reflux extraction is performed with a 70% ethanol solution at a solid-liquid ratio of 1:15. The temperature is controlled at 85°C for 2 hours, and the Rhodiola rosea extract (salidroside content ≥3%) is obtained after concentration and drying; the sea buckthorn fruit is frozen and crushed at -40°C, and the oil is separated by supercritical CO2 extraction (pressure 35MPa, temperature 55°C). The residue is extracted with hot water (solid-liquid ratio 1:10, 90°C / 1h), and spray-dried to obtain sea buckthorn powder (total flavonoids ≥40%); American ginseng is sliced ​​and ultrasonically extracted with 50% methanol (power 300W, 40kHz / 30min), concentrated and freeze-dried to obtain American ginseng extract (ginsenoside Rg1+Rb1 ≥5%). All extracts meet the standards of the 2020 edition of the Chinese Pharmacopoeia, with a moisture content of ≤8% and heavy metal lead ≤0.5mg / kg.

[0046] 2. Formulation composition and mixing process

[0047] The basic formula of the two chewing gums is composed of the following by mass percentage: gum base (polyvinyl acetate) accounts for 35%, mogroside 0.02%-0.5%, active mixture 7.5%, menthol 0.5%, sorbitol 40.5%-40.92%, and the balance is purified water. The active mixture has different configurations:

[0048] Lemon mint flavor: Rhodiola rosea extract 2.0%, sea buckthorn powder 4.0%, American ginseng extract 1.0%, caffeine (in compliance with GB14758-2010) 0.03%, lemon mint essence 0.4%, ginseng extract (saponins ≥ 80%) 1.0%, astragalus polysaccharide (molecular weight 10kDa) 1.07%.

[0049] 3. Key process control points

[0050] The lemon mint flavor is added in two steps: 50% is premixed with the solid ingredients, and the remaining 50% is injected into the gum base after it has cooled to 45°C to ensure flavor stability. During the extrusion process, tablet weight is controlled at 1.5±0.1g / tablet, with a hardness of 45-50N (as measured by a texture analyzer). The packaging environment humidity is maintained at ≤30% to prevent moisture absorption and sticking.

[0051] 4. Quality control and effect verification

[0052] The finished product is tested for microbial and physical and chemical indicators according to GB17399-2016, and its efficacy is verified by the following methods:

[0053] Instant refreshing effect: EEG monitoring of beta wave power changes after chewing showed a significantly higher increase of 18.2±2.7% in beta wave power within 30 seconds than the lemon mint version (p<0.01).

[0054] Sustained anti-fatigue ability: After taking the drug for 14 consecutive days, the error rates of the two groups in the cognitive ability test (IVA-CPT) decreased by 61.5% and 58.7%, respectively, and the salivary cortisol concentration decreased by 42.3% (ELISA method);

[0055] Safety index: acute oral toxicity test LD 50 >15g / kg, in compliance with food safety standards.

[0056] Example 1: Lemon mint flavored chewing gum

[0057] Step 1: Active ingredient pretreatment

[0058] Rhodiola rosea extract: Take 200 g of dried Rhodiola rosea rhizome, crush it and pass it through a 60-mesh sieve, add 3000 mL of 70% ethanol solution, reflux extract at 85°C for 2 hours, concentrate under reduced pressure to an extract, freeze-dry to obtain Rhodiola rosea extract (salidroside content 3.2%), grind it into powder for later use.

[0059] Sea buckthorn extract: After removing the seeds from the sea buckthorn fruit, take 500 g of pulp, quick-freeze and crush at -40°C, defatted by supercritical CO2 extraction (pressure 35 MPa, temperature 55°C), add 5000 mL of hot water (90°C) to the residue and soak for 1 hour, centrifuge, take the supernatant and spray dry to obtain sea buckthorn powder (total flavonoid content 42.1%).

[0060] American ginseng extract: 100 g of American ginseng slices were ultrasonically treated with 1500 mL of 50% methanol solution (power 300 W, 40 kHz) for 30 minutes, filtered, concentrated, and freeze-dried to obtain American ginseng extract (total ginsenoside Rg1+Rb1 content 5.5%).

[0061] Caffeine treatment: Food grade caffeine (GB14758-2010) was directly passed through a 100-mesh sieve and the dosage was controlled to 0.03% of the total mass.

[0062] Step 2: Preparation of auxiliary materials and flavor system

[0063] Base material composition: polyvinyl acetate gum base 350g (35.0%), mogroside 0.3g (0.03%), sorbitol 409.2g (40.92%), pure water 145.5g (14.55%).

[0064] Active mixture: Rhodiola rosea extract 20g (2.0%), sea buckthorn powder 40g (4.0%), American ginseng extract 10g (1.0%), caffeine 0.3g (0.03%), ginseng extract (saponins ≥ 80%) 10g (1.0%), astragalus polysaccharide 10.7g (1.07%).

[0065] Flavor addition: 4.0g (0.4%) of lemon mint flavor was added in two portions: 50% was premixed with the solid raw materials, and the remaining 50% was injected into the gum base when it was cooled to 45°C.

[0066] Step 3: Mixing and molding

[0067] Gum base melting: polyvinyl acetate gum base is melted in a water bath at 55±2℃.

[0068] Base material mixing: 409.2 g of sorbitol and 0.3 g of mogroside were added in sequence, and shear stirred at 1200 rpm for 15 minutes until homogeneous.

[0069] Active ingredient dispersion: Cool to 40°C, add active mixture and remaining mint essence, and degas under vacuum (-0.08 MPa, 10 minutes).

[0070] Extrusion cutting: Molded by twin-screw extruder, the tablet weight is controlled to 1.5g±0.1g, the hardness is 48±2N, and sealed and packaged after cooling.

[0071] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. A lemon-mint flavored, refreshing, anti-fatigue chewing gum containing natural active ingredients, comprising a gum base, a sweetener, and an active ingredient mixture, characterized by: The active ingredient mixture includes rhodiola rosea extract, sea buckthorn extract, caffeine and American ginseng extract, wherein the active ingredient mixture is configured to provide a refreshing effect by stimulating the central nervous system.

2. The lemon-mint flavored refreshing and anti-fatigue chewing gum containing natural active ingredients according to claim 1, characterized in that: The active ingredient mixture further comprises an additional ingredient for stimulating the central nervous system, wherein the additional ingredient is selected from at least one of a ginseng extract and an astragalus extract.

3. The lemon-mint flavored refreshing and anti-fatigue chewing gum containing natural active ingredients according to claim 1, characterized in that: The additional ingredients for stimulating the central nervous system include ginseng extract and astragalus extract to enhance physical strength and anti-fatigue effects.

4. The lemon-mint flavored refreshing and anti-fatigue chewing gum containing natural active ingredients according to claim 1, characterized in that: The chewing gum contains lemon mint flavoring agent, and the content of the lemon mint flavoring agent is 0.1% to 1.0% of the total weight of the chewing gum.

5. The lemon-mint flavored refreshing and anti-fatigue chewing gum containing natural active ingredients according to claim 1, characterized in that: The sweetener is natural monk fruit extract, namely mogroside, the content of which accounts for 0.02%-0.5% of the total weight of the chewing gum. The sweetener also includes sorbitol, which accounts for 40.5%-40.92% of the total weight of the chewing gum.

6. The lemon-mint flavored refreshing and anti-fatigue chewing gum containing natural active ingredients according to claim 1, characterized in that: The proportion of the active ingredient mixture meets the following range: Rhodiola rosea extract accounts for 1% to 5% of the total weight of the chewing gum, sea buckthorn extract accounts for 3% to 10%, caffeine accounts for 0.01% to 0.1%, and American ginseng extract accounts for 1% to 5%.

7. The lemon-mint flavored refreshing and anti-fatigue chewing gum containing natural active ingredients according to claim 1, characterized in that: All ingredients are from the "List of Substances that are Both Food and Medicine" published by the National Health Commission, and the chewing gum complies with GB17399-2016 "National Food Safety Standard Candy" and GB14758-2010 "Food Additive Caffeine Use Requirements".

8. The lemon-mint flavored refreshing and anti-fatigue chewing gum containing natural active ingredients according to claim 1, characterized in that: The chewing gum further comprises auxiliary ingredients, wherein the auxiliary ingredients include at least one of B vitamins or electrolytes to improve nerve function.

9. A method for preparing a lemon-mint flavored refreshing and anti-fatigue chewing gum containing natural active ingredients, characterized in that: The following steps are involved: Heat the gum base to 40-60°C, mix the sweetener and active ingredient mixture, and add flavoring to form the gum base.

10. A method for using a lemon mint flavored refreshing and anti-fatigue chewing gum containing natural active ingredients, characterized by: It releases the active ingredient by chewing to provide a short-term refreshing effect within 10 minutes and a long-term anti-fatigue effect after 14 days through continuous use.