Qiyuan qi-tonifying blood-enriching oral liquid and production process thereof

Abstract

The invention discloses a qi-tonifying and blood-enriching oral liquid and a production process, and relates to the technical field of health-care food, the qi-tonifying and blood-enriching oral liquid comprises the following components: 100g of astragalus membranaceus, 100g of angelica sinensis, 20g of longan aril, 300mL of hydrolyzed protein liquid, 200g of sucrose and 0.3 g of ethylparaben. According to the qi-tonifying and blood-enriching oral liquid for Qiyuan and the production process, through multiple times of decoction, active ingredients in medicinal materials such as radix astragali and radix angelicae sinensis are fully released, and active ingredient residues are avoided; the filtrate is concentrated into clear paste with the relative density of 1.10, so that the volume of the liquid medicine is reduced, the subsequent alcohol precipitation operation is facilitated, part of moisture is removed while effective components are reserved, the ethanol consumption during alcohol precipitation is reduced, and the cost is saved; water-soluble impurities such as polysaccharide, protein and tannin in liquid medicine are precipitated through ethyl alcohol, effective components such as flavone, saponin and small molecule glycoside are reserved, complete precipitation is ensured by standing for 12 hours at normal temperature, and the purity of the components is effectively improved after alcohol precipitation.

Description

Technical Field

[0001] The present invention relates to the technical field of health-care foods, in particular to an Qiyuan Qi-invigorating and blood-tonifying oral liquid and a production process thereof. Background Art

[0002] Blood is a red, opaque, viscous liquid that flows through the human body's blood vessels and heart. It performs four functions: transportation, regulating body temperature, defense, and regulating osmotic pressure and acid-base balance. A sufficient blood supply results in a rosy complexion, clear vision, firm and muscular structure, lustrous skin and hair, strong tendons and bones, and flexible sensation and movement. A blood deficiency, in addition to impaired organ and tissue function, can also manifest as a sallow complexion, blurred vision, pale lips and nails, withered skin and fur, wasting muscles, weakened tendons and bones, numbness in limbs, and limited mobility.

[0003] Currently, there are products on the market specifically for blood tonification. Most of these products simply supplement iron, or add inorganic or organic iron to conventional blood-tonifying traditional Chinese medicine preparations. These products have a certain effect on iron-deficiency anemia, but have little effect on nutritional anemia. To address this issue, the present invention provides a Qiyuan Yiqi Buxue Oral Liquid and a production process to address the above-mentioned problems. Summary of the Invention

[0004] In view of the deficiencies in the prior art, the present invention provides a Qiyuan Yiqi Buxue oral liquid and a production process, which solves the problems mentioned in the above background technology.

[0005] To achieve the above objectives, the present invention is implemented through the following technical scheme: a Qiyuan Yiqi Buxue oral liquid, comprising the following components: 100g of astragalus, 100g of angelica, 20g of longan meat, 300mL of hydrolyzed protein liquid, 200g of sucrose, and 0.3g of ethyl hydroxybenzoate.

[0006] A production process of Qiyuan Yiqi Buxue oral liquid comprises the following steps:

[0007] Step 1: Pre-treatment of medicinal materials: Select the astragalus and angelica, remove the non-medicinal parts, wash them, take them out and cut them into sections, and remove impurities and non-medicinal parts from the longan flesh;

[0008] Step 2, extraction: Pour the processed astragalus, angelica and longan meat into an extraction tank, add water and boil three times, and then filter the liquid through a double filter and combine it in a liquid storage tank;

[0009] Step 3: Primary concentration: The filtrate in the liquid storage tank is pumped into the concentrator and concentrated to a clear paste with a relative density of 1.10;

[0010] Step 4: Alcohol precipitation: Cool the paste to below 40°C at room temperature, then place it in an alcohol precipitation tank. Slowly add ethanol while stirring. Continue stirring for 30 minutes after adding ethanol, and then let it stand at room temperature for 12 hours.

[0011] Step 5: Secondary concentration: Filter through a pipeline filter with 200-mesh filter cloth to a concentrator and concentrate to a clear paste with a relative density of 1.22;

[0012] Step 6. Collect the paste: Add 350mL of water to the clear paste, stir well, let it stand for 12 hours and then filter. Add hydrolyzed protein solution, sucrose, and ethylparaben to the filtrate, boil and dissolve, add water to adjust the total amount to 1000mL, stir well, fill, and sterilize.

[0013] Preferably, in step 1, the astragalus and angelica are cut into small segments of 5 to 15 cm.

[0014] Preferably, in step 2, 5 times the amount of water is added for the first time and boiled for 1.5 hours, 5 times the amount of water is added for the second time and boiled for 1 hour, and 5 times the amount of water is added for the third time and boiled for 1 hour.

[0015] Preferably, in step 2, the boiling temperature is 100±5° C.; the steam pressure is less than 0.3 MPa; and the filter cloth mesh size is 200 mesh.

[0016] Preferably, in step 3, the concentration parameter requirements are: steam pressure less than 0.2 MPa; vacuum degree of the first effect is -0.04 to -0.08 MPa; vacuum degree of the second effect is -0.06 to -0.08 MPa; temperature of the first effect is 60 to 90°C; temperature of the second effect is 50 to 80°C.

[0017] Preferably, in step 4, the amount of ethanol added to the solution system is 65%.

[0018] Preferably, in step five, the concentration parameter requirements are: steam pressure of 0.02 to 0.1 MPa; temperature of 60 to 90° C.; and vacuum degree of -0.02 to -0.06 MPa.

[0019] Beneficial effects

[0020] The present invention provides a Qiyuan Qi-tonifying and blood-replenishing oral liquid and its production process. Compared with the prior art, it has the following beneficial effects:

[0021] (1) The Qiyuan Yiqi Buxue oral liquid and its production process, through multiple decoctions, fully release the active ingredients in the medicinal materials such as Astragalus and Angelica, and avoid the residue of the active ingredients; the filtrate is concentrated to a clear paste with a relative density of 1.10, reducing the volume of the liquid, facilitating the subsequent alcohol precipitation operation, and while retaining the active ingredients, removing part of the water, reducing the amount of ethanol used during the alcohol precipitation, and saving costs.

[0022] (2) The Qiyuan Yiqi Buxue oral liquid and its production process use ethanol to precipitate water-soluble impurities such as polysaccharides, proteins, and tannins in the liquid, while retaining effective ingredients such as flavonoids, saponins, and small molecule glycosides. The liquid is left to stand at room temperature for 12 hours to ensure complete precipitation. The purity of the ingredients is effectively improved after alcohol precipitation. At the same time, the alcohol precipitation step can remove impurities and reduce turbidity and precipitation during the storage of the preparation, thereby improving product stability and reducing possible gastrointestinal irritation after taking the liquid. Combined with secondary concentration to a clear paste with a relative density of 1.22, the concentration of the effective ingredients is further increased, laying the foundation for the subsequent addition of excipients (such as sucrose and hydrolyzed protein liquid) to adjust the taste and dosage. This concentration can not only ensure the fluidity of the paste, but also avoid the difficulty of filling due to excessive viscosity.

[0023] (3) The Qiyuan Yiqi Buxue oral liquid and its production process supplement amino acids through hydrolyzed protein liquid, which works synergistically with the qi-tonifying and blood-nourishing components of astragalus and angelica to enhance the tonic effect; sucrose improves the taste, reduces the bitterness of traditional Chinese medicine, and improves patient compliance; ethylparaben is used as a preservative to inhibit microbial growth and ensure the sterility of the product during its shelf life; water is added to adjust the total volume to 1000 mL and the liquid is sealed and sterilized to ensure the accurate dosage of each bottle, which meets the hygiene standards of oral liquid preparations. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 The present invention provides a production process flow chart. DETAILED DESCRIPTION

[0025] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0026] Example 1

[0027] A production process of Qiyuan Yiqi Buxue oral liquid comprises the following steps:

[0028] Step 1: Pre-treatment of medicinal materials: Select the astragalus and angelica, remove the non-medicinal parts, wash them, and then cut them into 5cm small pieces to remove impurities and non-medicinal parts of the longan flesh;

[0029] Step 2, extraction: Pour the processed 100g of astragalus, 100g of angelica and 20g of longan meat into an extraction tank, add water and boil three times: add 5 times the amount of water for the first time, boil for 1.5 hours, add 5 times the amount of water for the second time, boil for 1 hour, add 5 times the amount of water for the third time, boil for 1 hour, the boiling temperature is 95°C, the steam pressure is less than 0.3MPa, the filter cloth mesh number is 200 mesh, and the liquid is filtered with a double filter into a liquid storage tank for merging;

[0030] Step 3: Primary concentration: The filtrate in the liquid storage tank is pumped into the concentrator and concentrated to a clear paste with a relative density of 1.10 (80°C). The concentration parameter requirements are: steam pressure 0.05Mpa; vacuum degree of the first effect is -0.04Mpa; vacuum degree of the second effect is -0.06Mpa; temperature of the first effect is 60°C; temperature of the second effect is 50°C;

[0031] Step 4: Alcohol precipitation: Cool the paste to 25°C at room temperature, then place it in an alcohol precipitation tank. Slowly add ethanol while stirring. Continue stirring for 30 minutes after adding ethanol, and then let it stand at room temperature for 12 hours.

[0032] For this explanation, when the ethanol recovered from the previous batch is not enough for the current batch of alcohol precipitation, 95% ethanol is used to make up for it. The order of addition is to add low-concentration ethanol first, then add 95% ethanol;

[0033] Step 5: Secondary concentration: Use a pipeline filter with 200 mesh filter cloth to filter into a concentrator and concentrate to a clear paste with a relative density of 1.22 (80°C). The concentration parameter requirements are: steam pressure 0.02Mpa; temperature 60°C; vacuum degree -0.02MPa;

[0034] Step 6. Collect the paste: Add 350mL of water to the clear paste, stir well, let it stand for 12 hours and then filter. Add 300mL of hydrolyzed protein solution, 200g of sucrose, and 0.3g of ethyl paraben to the filtrate, boil and dissolve, add water to adjust the total amount to 1000mL, stir well, fill and sterilize.

[0035] Example 2

[0036] A production process of Qiyuan Yiqi Buxue oral liquid comprises the following steps:

[0037] Step 1: Pre-treatment of medicinal materials: Select the astragalus and angelica, remove the non-medicinal parts, wash them, and then cut them into 10cm small pieces to remove impurities and non-medicinal parts of the longan flesh;

[0038] Step 2, extraction: Pour the processed 100g of astragalus, 100g of angelica and 20g of longan meat into an extraction tank, add water and boil three times: add 5 times the amount of water for the first time, boil for 1.5 hours, add 5 times the amount of water for the second time, boil for 1 hour, add 5 times the amount of water for the third time, boil for 1 hour, the boiling temperature is 100°C, the steam pressure is 0.2MPa, the filter cloth mesh number is 200 mesh, and the liquid is filtered with a double filter into a liquid storage tank for merging;

[0039] Step 3: Primary concentration: The filtrate in the liquid storage tank is pumped into the concentrator and concentrated to a clear paste with a relative density of 1.10 (82°C). The concentration parameter requirements are: steam pressure 0.1Mpa; vacuum degree of the first effect is -0.06Mpa; vacuum degree of the second effect is -0.07Mpa; temperature of the first effect is 75°C; temperature of the second effect is 65°C;

[0040] Step 4: Alcohol precipitation: Cool the paste to 30°C at room temperature, then place it in an alcohol precipitation tank. Slowly add ethanol while stirring. Continue stirring for 30 minutes after adding ethanol, and then let it stand at room temperature for 12 hours.

[0041] For this explanation, when the ethanol recovered from the previous batch is not enough for the current batch of alcohol precipitation, 95% ethanol is used to make up for it. The order of addition is to add low-concentration ethanol first, then add 95% ethanol;

[0042] Step 5: Secondary concentration: Use a pipeline filter with 200 mesh filter cloth to filter into a concentrator and concentrate to a clear paste with a relative density of 1.22 (82°C). The concentration parameter requirements are: steam pressure 0.06Mpa; temperature 75°C; vacuum degree -0.04MPa;

[0043] Step 6. Collect the paste: Add 350mL of water to the clear paste, stir well, let it stand for 12 hours and then filter. Add 300mL of hydrolyzed protein solution, 200g of sucrose, and 0.3g of ethyl paraben to the filtrate, boil and dissolve, add water to adjust the total amount to 1000mL, stir well, fill and sterilize.

[0044] Example 3

[0045] A production process of Qiyuan Yiqi Buxue oral liquid comprises the following steps:

[0046] Step 1: Pre-treatment of medicinal materials: Select the astragalus and angelica, remove the non-medicinal parts, wash them, and then cut them into 15cm small pieces to remove impurities and non-medicinal parts of the longan flesh;

[0047] Step 2, extraction: Pour the processed 100g of astragalus, 100g of angelica and 20g of longan meat into an extraction tank, add water and boil three times: add 5 times the amount of water for the first time, boil for 1.5 hours, add 5 times the amount of water for the second time, boil for 1 hour, add 5 times the amount of water for the third time, boil for 1 hour, the boiling temperature is 105°C, the steam pressure is 0.25MPa, the filter cloth mesh number is 200 mesh, and the liquid is filtered with a double filter into a liquid storage tank for merging;

[0048] Step 3: Primary concentration: The filtrate in the liquid storage tank is pumped into the concentrator and concentrated to a clear paste with a relative density of 1.10 (85°C). The concentration parameter requirements are: steam pressure 0.15Mpa; vacuum degree of the first effect is -0.08Mpa; vacuum degree of the second effect is -0.08Mpa; temperature of the first effect is 90°C; temperature of the second effect is 80°C;

[0049] Step 4: Alcohol precipitation: Cool the paste to 35°C at room temperature, then place it in an alcohol precipitation tank. Slowly add ethanol while stirring. Continue stirring for 30 minutes after adding ethanol, and then let it stand at room temperature for 12 hours.

[0050] For this explanation, when the ethanol recovered from the previous batch is not enough for the current batch of alcohol precipitation, 95% ethanol is used to make up for it. The order of addition is to add low-concentration ethanol first, then add 95% ethanol;

[0051] Step 5: Secondary concentration: Use a pipeline filter with 200 mesh filter cloth to filter into a concentrator and concentrate to a clear paste with a relative density of 1.22. The concentration parameter requirements are: steam pressure 0.1Mpa; temperature 90℃; vacuum degree -0.06MPa;

[0052] Step 6. Collect the paste: Add 350mL of water to the clear paste, stir well, let it stand for 12 hours and then filter. Add 300mL of hydrolyzed protein solution, 200g of sucrose, and 0.3g of ethyl paraben to the filtrate, boil and dissolve, add water to adjust the total amount to 1000mL, stir well, fill and sterilize.

[0053] Comparative Example 1

[0054] Compared with Example 1, the difference is that the alcohol precipitation and secondary concentration steps are deleted, and the rest remain unchanged.

[0055] In this technical solution, the calculation formula for the amount of ethanol required to achieve 65% (V / V) alcohol precipitation is:

[0056]

[0057] Where, - Weight of clear paste; - Add the first ethanol weight; -The weight of the second ethanol to be added;

[0058] - relative density of the clear paste; - Add the first ethanol density; - Add a second ethanol density;

[0059] - adding a first ethanol concentration; - Add a second ethanol concentration.

[0060] Usage and dosage: Take about 10 grams of the herbal medicine twice a day after meals.

[0061] Criteria for judging efficacy:

[0062] Recovery: clinical symptoms such as dizziness and fatigue disappear, Hb (hemoglobin)>110g / L, red blood cells (RBC) ≥3.5×10 12 / L; effective: clinical symptoms such as dizziness and fatigue were significantly improved, RBC increased but did not reach the normal range, and the increase in Hb before and after treatment was ≥20g / L; ineffective: clinical symptoms did not change significantly, RBC did not increase, and the increase in Hb before and after treatment was <20g / L.

[0063] 60 patients were divided into 4 groups and taken the ointments of Example 1, Example 2, Example 3 and Comparative Example 1 respectively. After taking the ointments for 8 consecutive weeks, the patients were observed and the average values ​​of the indicators were taken. The results are shown in Table 1.

[0064] Table 1

[0065]

[0066] As shown in Table 1, the conditions of the patients who took the ointments of Examples 1-3 were significantly improved.

[0067] Meanwhile, the contents not described in detail in this specification belong to the prior art known to those skilled in the art.

[0068] It should be noted that, in this document, relational terms such as first and second, etc., are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprises," "comprising," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that includes a list of elements includes not only those elements but also other elements not explicitly listed, or elements inherent to such process, method, article, or apparatus.

[0069] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. A Qiyuan Yiqi Buxue Oral Liquid, characterized in that: The invention comprises the following components: 100g of astragalus, 100g of angelica, 20g of longan meat, 300mL of hydrolyzed protein liquid, 200g of sucrose and 0.3g of ethyl hydroxybenzoate.

2. A production process of the Qiyuan Yiqi Buxue oral liquid according to claim 1, characterized in that: The following steps are involved: Step 1: Pre-treatment of medicinal materials: Select the astragalus and angelica, remove the non-medicinal parts, wash them, take them out and cut them into sections, and remove impurities and non-medicinal parts from the longan flesh; Step 2: Extraction: Pour the processed astragalus, angelica and longan pulp into an extraction tank, add water and boil three times, and then filter the liquid through a double filter and combine it in a liquid storage tank; Step 3: Primary concentration: The filtrate in the liquid storage tank is pumped into the concentrator and concentrated to a clear paste with a relative density of 1.10; Step 4: Alcohol precipitation: Cool the paste to below 40°C at room temperature, then place it in an alcohol precipitation tank. Slowly add ethanol while stirring. Continue stirring for 30 minutes after adding ethanol, and then let it stand at room temperature for 12 hours. Step 5: Secondary concentration: Filter through a pipeline filter with 200-mesh filter cloth to a concentrator and concentrate to a clear paste with a relative density of 1.22; Step 6. Collect the paste: Add 350mL of water to the clear paste, stir well, let it stand for 12 hours and then filter. Add hydrolyzed protein solution, sucrose, and ethylparaben to the filtrate, boil and dissolve, add water to adjust the total amount to 1000mL, stir well, fill, and sterilize.

3. The production process of the Qiyuan Yiqi Buxue oral liquid according to claim 2, characterized in that: In the step 1, the astragalus and angelica are cut into small segments of 5 to 15 cm.

4. The production process of the Qiyuan Yiqi Buxue oral liquid according to claim 2, characterized in that: In the step 2, add 5 times the amount of water for the first time and boil for 1.5 hours, add 5 times the amount of water for the second time and boil for 1 hour, and add 5 times the amount of water for the third time and boil for 1 hour.

5. The production process of the Qiyuan Yiqi Buxue oral liquid according to claim 2, characterized in that: In the step 2, the boiling temperature is 100±5° C.; the steam pressure is less than 0.3 MPa; and the filter cloth mesh size is 200 meshes.

6. The production process of the Qiyuan Yiqi Buxue oral liquid according to claim 2, characterized in that: In step 3, the concentration parameter requirements are: steam pressure less than 0.2 MPa; vacuum degree of the first effect is -0.04 to -0.08 MPa; vacuum degree of the second effect is -0.06 to -0.08 MPa; temperature of the first effect is 60 to 90° C.; temperature of the second effect is 50 to 80° C.

7. The production process of the Qiyuan Yiqi Buxue oral liquid according to claim 2, characterized in that: In the step 4, the ethanol added to the solution system has an alcohol content of 65%.

8. The production process of the Qiyuan Yiqi Buxue oral liquid according to claim 2, characterized in that: In the step 5, the concentration parameters are as follows: steam pressure of 0.02 to 0.1 MPa; temperature of 60 to 90° C.; and vacuum degree of -0.02 to -0.06 MPa.

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