Nutrient composition for promoting muscle growth and preparation method, preparation and application thereof

Abstract

The invention provides a nutritional composition for promoting muscle growth and a preparation method, a preparation and application thereof, and the nutritional composition mainly comprises calcium beta-hydroxy-beta-methylbutyrate and mulberry extract in a weight ratio of 1: (0.5-50). According to the invention, the calcium beta-hydroxy-beta-methylbutyrate and the mulberry extract have a good synergistic effect, so that not only is the absorption efficiency of nutritional ingredients in the body significantly improved, but also the bioavailability of the calcium beta-hydroxy-beta-methylbutyrate is enhanced; therefore, more obvious muscle protection and overall physiological function regulation effects are realized; the calcium beta-hydroxy-beta-methylbutyrate preparation is especially suitable for middle-aged and elderly people, the mulberry extract is matched, the defects of a traditional calcium beta-hydroxy-beta-methylbutyrate preparation in the aspects of taste and taking compliance can be effectively overcome, and the compliance of long-term taking is remarkably improved; besides, sweet substances and flavor factors naturally existing in the mulberries can effectively cover bad taste possibly generated by the beta-hydroxy-beta-methyl calcium butyrate, so that the product is easier to accept by consumers, and the popularization value and application potential of the product in the market are further improved.

Description

Technical Field

[0001] The present invention relates to the technical field of food processing, and in particular to a nutrient composition for promoting muscle growth, a preparation method thereof, a preparation and use thereof. Background Art

[0002] Mulberries contain 19 kinds of amino acids, and the amino acid content is 4.0 to 6.5 times higher than that of stone fruits. They are rich in minerals and nutrients such as vitamin C, vitamin K, iron, potassium, dietary fiber, etc. They have antioxidant, immunity-enhancing and digestion-promoting effects.

[0003] Modern pharmacological research has revealed the various health benefits of mulberries, including antioxidant, anti-inflammatory, immune conditioning, hypoglycemic, hypolipidemic, anti-tumor, liver protection, cognitive improvement, and digestion-promoting effects.

[0004] Multiple studies have confirmed that calcium β-hydroxy-β-methylbutyrate (HMB calcium) has significant effects in improving athletic performance and endurance, post-exercise recovery, muscle gain and fat loss, as well as preventing and treating muscle wasting syndrome and promoting wound healing, and can meet the health needs of a variety of people.

[0005] As an effective nutritional intervention for preventing and treating sarcopenia, HMB calcium has been confirmed in numerous clinical studies. Supplementation with HMB calcium can help improve body composition in the elderly and effectively prevent and treat weight loss caused by prolonged bed rest or hospitalization. HMB calcium has also been clinically proven to accelerate wound healing and inhibit inflammation.

[0006] In the field of specialty medical dietary supplements, Abbott has developed a large number of products based on HMB calcium, achieving significant success. A full understanding of sarcopenia and proactive prevention and treatment are crucial for improving the quality of life of the elderly and reducing complications.

[0007] Some patents describe pharmaceuticals or health foods specifically for the elderly, those bedridden or hospitalized, and those suffering from sarcopenia. However, the elderly suffer from insufficient gastrointestinal absorption capacity, preventing them from fully absorbing the nutrients in these foods. Furthermore, existing HMB calcium health foods are limited in variety and have a poor taste, failing to fully meet the needs of the general public. Furthermore, no nutritional supplements have been found that combine mulberries with HMB calcium to synergistically promote muscle growth or prevent muscle decline in the elderly. Summary of the Invention

[0008] Therefore, the present invention provides a nutritional composition of HMB calcium and mulberry extract to solve the problem of insufficient HMB calcium absorption capacity of the elderly.

[0009] The present invention aims to solve the problem that the existing HMB calcium health food has a single style and cannot meet the needs of the public, and provides a nutritional composition preparation of HMB calcium and mulberry extract and a preparation method thereof.

[0010] According to an embodiment of the present application, in a first aspect, a nutritional composition for promoting muscle growth is provided, comprising calcium β-hydroxy-β-methylbutyrate and mulberry extract in a weight ratio of 1:0.5 to 50.

[0011] Calcium β-hydroxy-β-methylbutyrate (hereinafter referred to as HMB calcium) is an intermediate metabolite of the essential amino acid leucine. It significantly improves muscle mass and strength, effectively promoting muscle regeneration, increasing muscle strength, increasing protein synthesis, and preventing muscle loss. It also inhibits muscle protein degradation and protects muscle tissue. Supplementation with HMB calcium helps improve body composition in the elderly and effectively prevents weight loss caused by prolonged bed rest or hospitalization. HMB calcium has also been clinically proven to accelerate wound healing and inhibit inflammation.

[0012] Mulberry fruits are also rich in anthocyanins, flavonoids, polyphenols, resveratrol, dietary fiber, vitamins, amino acids and other ingredients. They have multiple functions and are known as "the best health fruit of the 21st century."

[0013] In the present invention, calcium β-hydroxy-β-methylbutyrate and mulberry extract have a good synergistic effect, which not only significantly improves the absorption efficiency of nutrients in the body, but also enhances the bioavailability of HMB calcium, thereby achieving more significant muscle protection and overall physiological function regulation effects; it is particularly suitable for middle-aged and elderly people. By combining with mulberry extract, it can effectively improve the shortcomings of traditional HMB calcium preparations in taste and compliance, and significantly improve long-term compliance; in addition, the naturally existing sweet substances and flavor factors in mulberries can effectively mask the unpleasant taste that may be caused by HMB calcium itself, making the product more easily accepted by consumers, thereby increasing its promotion value and application potential in the market.

[0014] As an embodiment of the present invention, the mulberry extract includes one or both of mulberry extract and concentrated mulberry juice.

[0015] As an embodiment of the present invention, the nutritional composition further comprises one or more of starch, lactose, sodium bicarbonate, and citric acid.

[0016] As an embodiment of the present invention, the nutritional composition comprises, by weight: 2 parts of calcium β-hydroxy-β-methylbutyrate and 100 parts of mulberry extract;

[0017] Alternatively, the nutritional composition comprises, by weight, 18 parts of calcium β-hydroxy-β-methylbutyrate, 10 parts of mulberry extract, 16 parts of soluble starch, 20 parts of lactose, 14 parts of sodium bicarbonate, and 12 parts of citric acid.

[0018] According to an embodiment of the present application, in a second aspect, the present application provides a method for preparing the above-mentioned nutritional composition, comprising: weighing raw materials according to a formula and mixing them.

[0019] As an embodiment of the present invention, calcium β-hydroxy-β-methylbutyrate and mulberry extract are weighed according to a ratio, added with water, and mixed to obtain the product;

[0020] Alternatively, calcium β-hydroxy-β-methylbutyrate and mulberry extract are weighed according to the ratio, the mulberry extract is granulated into whole particles, mixed with calcium β-hydroxy-β-methylbutyrate, and compressed to obtain the product.

[0021] According to an embodiment of the present application, in a third aspect, the present application provides a nutritional composition preparation, comprising the above nutritional composition, or a nutritional composition prepared by the above method.

[0022] As an embodiment of the present invention, the nutritional composition preparation includes a liquid preparation or a solid preparation;

[0023] As an embodiment of the present invention, the nutritional composition preparation further includes effervescent tablets, beverages, candies, and baked goods.

[0024] The nutritional composition formulation of the present invention has good application flexibility and palatability and can be processed into various dosage forms according to specific usage scenarios and consumer needs. The composition can be prepared into one or more of effervescent tablets, beverages, candies, or baked goods.

[0025] Effervescent tablets facilitate quantitative control and dissolve quickly, making them suitable for rapid nutritional supplementation. Beverages offer ready-to-drink consumption and are suitable for popular daily supplementation scenarios. Candy formulations are suitable for children or those who are not accustomed to swallowing tablets. Baked goods such as nutritional biscuits and energy bars help incorporate the nutritional composition into daily meals, increasing the convenience and enjoyment of ingestion. These diverse formulation methods enhance the application potential of the present composition in multiple fields, including nutrition and health, functional foods, and sports nutrition.

[0026] According to an embodiment of the present invention, in a fourth aspect, the present application provides the use of the above-mentioned nutritional composition or the nutritional composition prepared by the above-mentioned preparation method or the above-mentioned nutritional composition preparation in any of the following:

[0027] (1) Use of a nutritional preparation for promoting muscle growth and / or preventing muscle loss;

[0028] (2) Preparation of functional foods for enhancing immunity, anti-oxidation, nourishing the liver and kidneys, and / or promoting digestion;

[0029] (3) The use of the present invention in preparing a nutritional supplement for improving the absorption efficiency of calcium β-hydroxy-β-methylbutyrate and / or improving the taste.

[0030] The technical solution of the present invention has the following advantages:

[0031] The present invention provides a nutrient composition for promoting muscle growth, comprising calcium β-hydroxy-β-methylbutyrate and mulberry extract in a weight ratio of 1:0.5-50. This nutrient composition promotes muscle growth, inhibits muscle protein degradation, and protects muscle tissue. It is suitable for consumption by the elderly and those who are bedridden or hospitalized for a long time.

[0032] 2. The present invention provides a nutritional composition for promoting muscle growth, wherein the mulberry extract has the effects of nourishing the liver and kidneys, anti-oxidation, enhancing immunity and promoting digestion, which is beneficial to the human body's absorption of HMB calcium.

[0033] 3. The nutritional composition preparation for promoting muscle growth provided by the present invention has a better taste after adding mulberry extract and can be accepted by the public. DETAILED DESCRIPTION

[0034] The following examples are provided for a better understanding of the present invention and are not intended to limit the best mode of implementation. They do not limit the content and scope of protection of the present invention. Any product identical or similar to the present invention obtained by anyone under the guidance of the present invention or by combining the features of the present invention with other prior arts shall fall within the scope of protection of the present invention.

[0035] If no specific experimental steps or conditions are specified in the examples, the conventional experimental steps or conditions described in the literature in this field can be used. If the manufacturer of the reagents or instruments is not specified, they are all commercially available conventional reagents.

[0036] In the present invention, the mulberry extract used is not limited. It can be a commercially available mulberry extract, concentrated mulberry juice or other ready-made products, or it can be homemade.

[0037] The mulberry extracts used in the examples and comparative examples of the present invention were prepared according to the following method:

[0038] Take mulberry raw material, add water equivalent to 10 times its mass, and perform decoction extraction twice, heating for 1.5 hours each time; after combining the extracts, concentrate them to obtain mulberry concentrated juice with a mass of about 58% of the raw material, which is the mulberry extract.

[0039] Example 1

[0040] This embodiment provides an HMB calcium-mulberry effervescent tablet and a preparation method thereof. The effervescent tablet is composed of the following raw materials:

[0041] HMB calcium: 18g;

[0042] Mulberry extract: 10g;

[0043] Soluble starch: 16g;

[0044] Lactose: 20g;

[0045] Sodium bicarbonate: 14g;

[0046] Citric acid: 12g.

[0047] The preparation method comprises the following steps:

[0048] S1. Weigh soluble starch and lactose according to the ratio and mix thoroughly;

[0049] S2, adding mulberry extract to the mixture and granulating by wet method;

[0050] S3, the obtained wet granules are passed through an 18-mesh sieve, dried, and passed through an 18-mesh sieve again to size the granules;

[0051] S4. Add HMB calcium, sodium bicarbonate and citric acid to the granulated material and mix well.

[0052] S5. Prepare effervescent tablets using a tablet press. Each tablet weighs 3 g and contains approximately 0.6 g of HMB calcium.

[0053] The effervescent tablet prepared by the above method has good disintegration performance and taste, can effectively provide HMB calcium nutritional supplement, and combined with mulberry ingredients to play a conditioning auxiliary role.

[0054] Example 2

[0055] This embodiment provides an HMB calcium-mulberry juice beverage and a preparation method thereof. The beverage is composed of the following ingredients:

[0056] HMB calcium 2g;

[0057] Mulberry extract: 100g;

[0058] Purified water: add to a total volume of 500ml;

[0059] The preparation method comprises the following steps:

[0060] S1. Weigh 2g of HMB calcium and 100g of mulberry extract according to the ratio;

[0061] S2. Add the above raw materials into purified water and adjust the total volume to 500 ml;

[0062] S3. Stir and mix thoroughly to evenly disperse the HMB calcium to obtain a finished beverage.

[0063] This beverage has a simple preparation process and a pleasant taste, offering both nutritional benefits and flavor. HMB calcium provides the body with β-hydroxy-β-methylbutyrate, while mulberry juice, rich in natural polyphenols and anthocyanins, enhances the product's health benefits.

[0064] Example 3

[0065] This embodiment provides an effervescent tablet prepared by mixing calcium β-hydroxy-β-methylbutyrate (calcium HMB) and mulberry extract in a weight ratio of 1:0.5, and a preparation method thereof. The effervescent tablet is composed of the following raw materials:

[0066] HMB calcium: 20g;

[0067] Mulberry extract: 10g;

[0068] Soluble starch: 20g;

[0069] Lactose: 24g;

[0070] Sodium bicarbonate: 14g;

[0071] Citric acid: 12g;

[0072] The preparation method comprises the following steps:

[0073] S1. Weigh soluble starch and lactose in proportion and mix well;

[0074] S2, adding mulberry extract and adopting wet granulation;

[0075] S3, the wet granules are passed through an 18-mesh sieve, dried, and sieved again to form whole granules;

[0076] S4. Add HMB calcium, sodium bicarbonate and citric acid and mix well.

[0077] S5. The mixture is compressed into tablets. Each tablet weighs 3 g and contains approximately 0.61 g of HMB calcium.

[0078] This effervescent tablet has good disintegration properties and flavor, and is suitable for sports nutrition supplementation or daily health care purposes.

[0079] Example 4

[0080] This embodiment provides a beverage prepared by mixing HMB calcium and mulberry extract in a weight ratio of 1:25 and a preparation method thereof. The beverage is composed of the following ingredients:

[0081] HMB calcium: 4g;

[0082] Mulberry extract: 100g;

[0083] Purified water: add to a total volume of 500ml;

[0084] The preparation method comprises the following steps:

[0085] S1. Weigh 4 g of HMB calcium and 100 g of mulberry extract according to the ratio;

[0086] S2. Add the above raw materials into purified water and adjust the total volume to 500 ml;

[0087] S3. Stir and mix thoroughly to evenly disperse the HMB calcium to obtain a finished beverage.

[0088] This beverage has a simple preparation process and a pleasant taste, offering both nutritional benefits and flavor. HMB calcium provides the body with β-hydroxy-β-methylbutyrate, while mulberries, rich in natural polyphenols and anthocyanins, contribute to the product's health benefits.

[0089] Comparative Example 1

[0090] The only difference between this comparative example and Example 1 is that the mulberry extract is replaced with soluble starch of equal mass. The soluble starch is only used as a filler in the effervescent tablet provided by the present invention, and its role is to facilitate tableting during the preparation process. The details are as follows:

[0091] The raw materials of HMB calcium effervescent tablets include:

[0092] HMB calcium: 18g;

[0093] Soluble starch: 26g;

[0094] Lactose: 20g;

[0095] Sodium bicarbonate: 14g;

[0096] Citric acid: 12g.

[0097] The preparation method comprises the following steps:

[0098] S1. Weigh soluble starch and lactose according to the ratio and mix thoroughly;

[0099] S2, granulating the mixture by wet method;

[0100] S3, the obtained wet granules are passed through an 18-mesh sieve, dried, and passed through an 18-mesh sieve again to size the granules;

[0101] S4. Add HMB calcium, sodium bicarbonate and citric acid to the granulated material and mix well.

[0102] S5. Prepare effervescent tablets using a tablet press. Each tablet weighs 3 g and contains approximately 0.6 g of HMB calcium.

[0103] Comparative Example 2

[0104] The only difference between this comparative example and Example 1 is that HMB calcium is replaced with an equal mass of soluble starch. The soluble starch is used only as a filler in the effervescent tablet provided by the present invention, and its function is to facilitate tableting during the preparation process; the details are as follows:

[0105] The raw materials of mulberry effervescent tablets include:

[0106] Mulberry extract: 10g;

[0107] Soluble starch: 34g;

[0108] Lactose: 20g;

[0109] Sodium bicarbonate: 14g;

[0110] Citric acid: 12g.

[0111] The preparation method comprises the following steps:

[0112] S1. Weigh soluble starch and lactose according to the ratio and mix thoroughly;

[0113] S2, adding mulberry extract to the mixture and granulating by wet method;

[0114] S3, the obtained wet granules are passed through an 18-mesh sieve, dried, and passed through an 18-mesh sieve again to size the granules;

[0115] S4. Add sodium bicarbonate and citric acid to the granulated material and mix well;

[0116] S5. Prepare effervescent tablets using a tablet press, each tablet weighing 3 g.

[0117] Experimental Example 1:

[0118] This experiment was conducted by randomly dividing the subjects into groups. The experiment lasted for thirty days. The experimental group and the control group each took corresponding products. The subjects' weight, body fat percentage and muscle weight were tested using the DX200 super-strong body composition tester at the beginning and end of the experiment.

[0119] 1.1 Experimental subjects and products

[0120] The experimental subjects were people aged between 60 and 70 years old who were able to move independently. All subjects were randomly divided into the following experimental and control groups:

[0121] Experimental group A: 20 people (9 males, 11 females, aged 65.6±2.21 years) took the effervescent tablets obtained in Example 1 3 tablets / day;

[0122] Experimental group B: 20 ​​people (12 males, 8 females, aged 67.2±1.86 years) took 500 ml / day of the sports drink obtained in Example 2;

[0123] Control group A: 20 subjects (13 males, 7 females, aged 64.9±2.59 years) took purified water 500 ml / day;

[0124] Control group B: 20 ​​people in the control group (12 males, 8 females, aged 63.8±1.87 years) took 3 effervescent tablets prepared in Comparative Example 1 per day;

[0125] Control group C: 20 people in the control group (11 males, 9 females, aged 65.7±2.39 years) took 3 effervescent tablets prepared in Comparative Example 2 per day.

[0126] 1.2 Experimental methods

[0127] The experimental period is 30 days. During the experiment, all subjects maintain a uniform diet structure and daily routine, and are not allowed to use other nutritional supplements or health products to eliminate interfering factors.

[0128] Body composition test: At the beginning and end of the experiment, the subjects' weight, body fat percentage and muscle weight were tested using a DX200 super-strong body composition tester.

[0129] 1.3 Results Statistics

[0130] The data were processed using Excel and statistically analyzed using the t-test. P>0.05 was considered to have no significant difference, P<0.05 was considered to have a significant difference, and P<0.01 was considered to have an extremely significant difference.

[0131] 2. Experimental Results

[0132] 2.1 The changes in body weight, body fat percentage, and muscle weight of the subjects before and after the experiment are shown in Table 1;

[0133] Table 1:

[0134]

[0135]

[0136] Note: P < 0.05, statistically significant compared with the control group; P < 0.01, significant difference compared with the control group; The data listed in Table 1 are the average values ​​of body weight, body fat percentage and muscle weight of the subjects in each group before and after the experiment.

[0137] Before the experiment began, the initial data differences in body weight, body fat percentage, and muscle weight between experimental group A, experimental group B, and control group A, control group B, and control group C were small, and statistical analysis (P>0.05) showed that the differences were not statistically significant, indicating that the groups were highly comparable and suitable for subsequent effect evaluation.

[0138] After the experiment, there was no significant change in the weight of the subjects in experimental group A, experimental group B and control group A, control group B, and control group C, indicating that the intervention had little effect on weight.

[0139] However, both experimental groups A and B showed significant improvements in body fat percentage and muscle mass. Specifically, group A's body fat percentage decreased from 24.1% to 21.9%, while group B's decreased from 25.4% to 22.9%. The differences between the two groups were statistically significant (P<0.01). Furthermore, group A's muscle mass increased significantly from 22.13kg to 24.33kg, while group B's increased from 22.94kg to 25.06kg, also achieving statistical significance (P<0.01).

[0140] In contrast, the control group A showed no significant changes in body fat percentage and muscle weight, further verifying that the intervention measures adopted by the experimental group had a clear and effective effect in promoting body fat reduction and muscle growth.

[0141] Control group B took effervescent tablets lacking mulberry extract (corresponding to control group 1). Their body fat percentage decreased from 24.3% to 22.9%, and muscle weight increased from 22.45kg to 23.89kg. Although both indicators improved to a certain extent, the overall effect was relatively limited and did not show a significant advantage. This shows that in the absence of mulberry active ingredients, the effect of HMB calcium in regulating body fat and promoting muscle growth is weakened, suggesting that mulberry extract has a synergistic promoting effect in overall function.

[0142] Control group C, which took effervescent tablets lacking HMB calcium (corresponding to control group 2), saw a slight decrease in body fat percentage from 23.9% to 23.6%, and a slight increase in muscle mass from 21.97 kg to 22.06 kg, with minimal changes. These results suggest that the intervention effect of mulberry extract alone on body fat control and muscle growth is limited, and that significant nutritional regulation is difficult to achieve without HMB calcium.

[0143] The functional food or preparation, which combines HMB calcium and mulberries, promotes muscle growth and prevents muscle loss in the elderly. Mulberries, known for their liver and kidney nourishing, antioxidant, immune-boosting, and digestive-promoting properties, further enhance HMB calcium absorption. The addition of mulberries improves the product's taste and is therefore widely accepted.

[0144] Obviously, the above embodiments are merely examples for clarity of explanation and are not intended to limit the implementation methods. Those skilled in the art will readily appreciate that other variations or modifications based on the above descriptions are possible. It is not necessary and impossible to enumerate all implementation methods here. Obvious variations or modifications arising therefrom remain within the scope of protection of the present invention.

Claims

1. A nutritional composition for promoting muscle growth, characterized in that: The invention comprises calcium beta-hydroxy-beta-methylbutyrate and mulberry extract, wherein the weight ratio of calcium beta-hydroxy-beta-methylbutyrate to mulberry extract is 1:0.5-50.

2. A nutritional composition for promoting muscle growth according to claim 1, characterized in that: The mulberry extract comprises one or both of mulberry extract and concentrated mulberry juice.

3. A nutritional composition for promoting muscle growth according to claim 1 or 2, characterized in that: The nutritional composition further comprises one or more of starch, lactose, sodium bicarbonate and citric acid.

4. A nutritional composition for promoting muscle growth according to claim 3, characterized in that: In parts by weight, the nutritional composition comprises: 2 parts of calcium β-hydroxy-β-methylbutyrate and 100 parts of mulberry extract; Alternatively, the nutritional composition comprises, by weight, 18 parts of calcium β-hydroxy-β-methylbutyrate, 10 parts of mulberry extract, 16 parts of soluble starch, 20 parts of lactose, 14 parts of sodium bicarbonate, and 12 parts of citric acid.

5. A method for preparing the nutritional composition according to any one of claims 1 to 4, characterized in that: include: Weigh the raw materials according to the recipe and mix them.

6. The method for preparing a nutritional composition according to claim 5, wherein: Weigh β-hydroxy-β-methylbutyrate calcium and mulberry extract according to the ratio, add water, and mix; Alternatively, calcium β-hydroxy-β-methylbutyrate and mulberry extract are weighed according to the ratio, the mulberry extract is granulated into whole particles, mixed with calcium β-hydroxy-β-methylbutyrate, and compressed to obtain the product.

7. A nutritional composition preparation, characterized in that A nutritional composition comprising the nutritional composition according to any one of claims 1 to 4 or a nutritional composition prepared by the method for preparing the nutritional composition according to claim 5 or 6.

8. The nutritional composition preparation according to claim 7, characterized in that The nutritional composition preparation may be in the form of a liquid preparation or a solid preparation.

9. The nutritional composition preparation according to claim 8, characterized in that The nutritional composition preparation comprises one or more of effervescent tablets, beverages, candies, and baked goods.

10. Use of the nutritional composition according to any one of claims 1 to 4 or the nutritional composition prepared by the method for preparing the nutritional composition according to claim 5 or 6 or the nutritional composition preparation according to any one of claims 7 to 9 in any of the following: (1) Use of a nutritional preparation for promoting muscle growth and / or preventing muscle loss; (2) Preparation of functional foods for enhancing immunity, anti-oxidation, nourishing the liver and kidneys, and / or promoting digestion; (3) The use of the present invention in preparing a nutritional supplement for improving the absorption efficiency of calcium β-hydroxy-β-methylbutyrate and / or improving the taste.

Images