Compound radix arnebiae seu lithospermi and seaweed gel preparation capable of improving skin problems

Abstract

The invention provides a compound lithospermum erythrorhizon seaweed gel preparation capable of improving skin problems, the preparation comprises a carrier and an active component connected with the carrier, the carrier is a sodium alginate gel matrix, the active component comprises a modified lithospermum erythrorhizon ointment mixture, the modified lithospermum erythrorhizon ointment mixture exists in a microcapsule form, and the microcapsule is a microcapsule. Wrapping the modified lithospermum ointment mixture serving as a water phase in an oil phase in the microcapsule; the modified radix arnebiae seu lithospermi ointment mixture is prepared from the following raw materials: radix arnebiae seu lithospermi, radix angelicae sinensis, radix angelicae, frankincense, myrrh, green tea, raw rhizoma typhonii, silkworm larva, radix astragali seu hedysari, flos lonicerae, flos chrysanthemi, rhizoma anemarrhenae and calcined gypsum. According to the invention, through a microcapsule packaging technology of the modified lithospermum ointment mixture with a specific ratio and in combination with a sodium alginate gel carrier, the stability and bioavailability of the active ingredients are remarkably improved, the slow release and long-acting effects of the active ingredients are realized, and meanwhile, the oil phase combination and preparation process are optimized; the skin problem is effectively improved on the premise of ensuring the mildness.

Description

Technical Field

[0001] The invention belongs to the technical field of skin care preparations, and particularly relates to a compound lithospermum parkii gel preparation capable of improving skin problems. Background Art

[0002] The field of skin care preparations, especially the application of traditional Chinese medicine formulas in beauty and treatment, has always been a focus of research and development. Among them, compound lithospermum preparations play an important role in improving skin problems with their significant anti-inflammatory, antibacterial, and wound healing effects. For example, traditional lithospermum ointment is widely used for symptoms such as acne, eczema, minor burns, and skin aging to help relieve inflammation, accelerate tissue repair, and provide a mild care effect. However, such products have a series of defects in actual application scenarios, which restrict their clinical effects and user comfort. Specifically, similar skin gel preparations currently available on the market mainly include gel-based products that are directly mixed with traditional Chinese medicine extracts. They face challenges in the formulation design and preparation process, resulting in unstable efficacy, low bioavailability, and inconvenient application.

[0003] From a functional perspective, compound Chinese herbal preparations are typically designed to synergize multiple components. These ingredients, primarily lithospermum erythrorhizon, are combined with other herbal ingredients, including angelica sinensis, white angelica root, frankincense, and myrrh, to deliver anti-inflammatory, antibacterial, and blood circulation-boosting benefits. Furthermore, the addition of ingredients such as green tea, astragalus root, and honeysuckle flower enhances antioxidant and immunomodulatory properties. These complex formulations are designed to address complex skin concerns, offering comprehensive benefits such as moisturizing, reducing infection risk, and accelerating cell regeneration. However, in practice, the active ingredients in traditional preparations are often directly suspended or dissolved in an aqueous matrix, making them susceptible to inactivation by light, heat, or humidity during storage and use. For example, ingredients such as frankincense, myrrh, and lithospermum erythrorhizon are inherently volatile or easily oxidized, resulting in rapid degradation in unprotected conditions. This ultimately results in a short shelf life and rapidly diminishing efficacy. Users often report that initial efficacy is significant but diminishes over time, sometimes even causing local irritation or allergies, impacting overall compliance and safety.

[0004] Existing technologies attempt to solve these problems, mainly by improving carrier systems and active ingredient protection strategies. A common practice is to use microencapsulation technology to prevent oxidation and prolong release by encapsulating aqueous Chinese herbal extracts in an oil phase. For example, some skin preparations use synthetic polymers or natural oils as microcapsule wall materials to encapsulate active ingredients. This method improves stability to a certain extent and achieves slow release to avoid skin overload. In addition, the use of gel matrices such as sodium alginate, through its good biocompatibility and water retention, provides a lubricating barrier to the skin while supporting the local delivery of active ingredients. In terms of preparation technology, existing technologies mostly rely on conventional emulsification or solvent methods to form microcapsules, and combine filtration and purification steps to ensure the purity of the ingredients. These improvements reduce ingredient loss and improve patient acceptance to a certain extent, especially reducing the risk of irritation when targeting sensitive skin.

[0005] However, while existing technologies have solved the above-mentioned defects, there are still many problems that have not been effectively addressed. First, there are limitations in the selection and application of the oil phase during the preparation of microcapsules. Many solutions use a single oil or a simple combination, such as relying solely on almond oil or grape seed oil, resulting in low encapsulation efficiency, fragile microcapsule structure, and easy rupture during stirring and storage, causing the active ingredients to leak prematurely and unable to maintain the target release curve. In practical applications, this manifests as the initial burst release of gel preparations on the skin. Some users report that the effect is too concentrated or the efficacy is insufficient in the later stages, and it is impossible to evenly cover the entire treatment cycle. Secondly, the existing aqueous Chinese medicine extracts are processed in a rough manner, such as the extraction temperature is too high or the filtration accuracy is insufficient, resulting in a decrease in the biological activity of active ingredients such as astragalus polysaccharides or shikonin; at the same time, improper strategies for adding complex enzymes, such as a single enzyme type or an imbalanced ratio, not only affect the extraction rate, but also introduce impurities that affect safety. Furthermore, the technology for combining microcapsules with the gel matrix also has flaws. Improper control of volume ratios and mixing conditions, such as stirring speed, often leads to microcapsule aggregation or uneven size, which in turn affects the uniform distribution of the gel and skin permeability. Clinical trials often result in uneven gel coating, making topical application difficult. Finally, the synergistic effects of the overall formulation have not been optimized. The effects of individual ingredients, such as Bombyx batryticatus, raw white atractylodes root, or calcined gypsum, are not fully utilized. Furthermore, the antibacterial enhancement properties of the microcapsule oil phase, such as rosemary essential oil, are often overlooked, resulting in less-than-expected anti-inflammatory and repair effects.

[0006] These issues collectively highlight the bottlenecks of existing compound skin preparations: insufficient protection of active ingredients, uncontrolled release, limited bioavailability, and poor product stability. These limitations not only restrict the widespread adoption of skin care formulations but also increase manufacturing costs and the risk of failure.

[0007] Therefore, it is necessary to design a compound lithospermum parkii gel preparation that can improve skin problems. Summary of the Invention

[0008] In order to overcome the defects in the prior art, a compound lithospermum parkii gel preparation capable of improving skin problems is provided.

[0009] In order to achieve the above object, the present invention provides the following technical solutions:

[0010] A compound lithospermum and seaweed gel preparation capable of improving skin problems comprises a carrier and an active ingredient connected thereto, wherein the carrier is a sodium alginate gel matrix, the active ingredient comprises a flavored lithospermum paste mixture, the flavored lithospermum paste mixture is present in the form of microcapsules, and an oil phase in the microcapsules encapsulates the flavored lithospermum paste mixture as a water phase; the flavored lithospermum paste mixture comprises the following raw materials: lithospermum, angelica, angelica dahurica, frankincense, myrrh, green tea, raw white rhizome, white bombyx batryticatus, astragalus, honeysuckle, chrysanthemum, rhizoma anemarrhenae, and calcined gypsum.

[0011] Calculated by mass, the ratio of each raw material in the modified lithospermum paste mixture is: 8-12 parts of lithospermum, 5-8 parts of angelica, 4-7 parts of angelica dahurica, 3-5 parts of frankincense, 3-5 parts of myrrh, 6-9 parts of green tea, 2-4 parts of raw white atractylodes, 3-6 parts of white bombyx batryticatus, 7-10 parts of astragalus, 6-9 parts of honeysuckle, 5-8 parts of chrysanthemum, 4-7 parts of anemarrhena, and 3-6 parts of calcined gypsum.

[0012] The preparation method of the modified lithospermum paste mixture comprises the following steps: grinding raw materials into 60-mesh particles, mixing the raw materials with deionized water in a ratio of 1:8-10 based on the total mass, extracting the raw materials in an 80°C water bath for 2 hours, performing primary filtration through a 200-mesh filter cloth and fine filtration through a 0.45-μm microporous filter membrane, and adding a complex enzyme in an amount of 0.1% of the total mass of the raw materials during the extraction process, wherein the complex enzyme consists of cellulase and pectinase of equal mass.

[0013] The oil phase in the microcapsule comprises sweet almond oil, grape seed oil and rosemary essential oil.

[0014] The mass ratio of the sweet almond oil, grape seed oil and rosemary essential oil is 3-5:1-2:1.

[0015] The preparation method of the microcapsule comprises: adding a microcapsule emulsion to a sodium alginate solution, wherein the volume ratio of the microcapsule emulsion to the sodium alginate solution is 1:20-22, stirring at 700 rpm for 1-15 minutes, washing with double distilled water 2-3 times, and then storing in a 0.24 g / L calcium chloride solution to obtain the microcapsule.

[0016] The microcapsule emulsion is prepared by stirring 11-13 parts by mass of an oil phase and 15-17 parts by mass of a Span 85 emulsifier at 60° C. and 800 rpm for 1 minute, adding 2-4 parts of an aqueous phase and 3-5 parts of a 0.24 g / L calcium chloride solution, and continuing to stir for 2 minutes to form an emulsion. The result is the microcapsule emulsion.

[0017] The sodium alginate solution is prepared by the following method: 10 g of sodium alginate is dissolved in 1 liter of double-distilled water, stirred at 500 rpm for 6 hours, and then allowed to stand at 4° C. for 24 hours to obtain the sodium alginate solution.

[0018] Compared with the prior art, the advantages and beneficial effects of the present invention are:

[0019] 1. This application has achieved multi-dimensional innovative breakthroughs in the field of transdermal delivery of traditional Chinese medicine by integrating sodium alginate gel matrix with microencapsulation technology. The three-dimensional cross-linked network structure of sodium alginate forms a dynamic barrier through calcium ion gradient cross-linking. This biomimetic structure simulates the natural protective function of the skin's stratum corneum, which can not only block the penetration of external pollutants, but also regulate the sustained release rate of active ingredients through ion exchange mechanism. Compared with the traditional vaseline matrix, the unique temperature-sensitive properties of this gel matrix cause it to undergo phase change and softening when in contact with the skin, perfectly fitting the curved surface of the human body, and is particularly suitable for the treatment of chronic dermatitis in the nose or joint area.

[0020] 2. The double-layer protection system of the microcapsule is the core technological breakthrough of this solution. Sweet almond oil is used as the main oil phase carrier. Its rich oleic acid glyceride is highly compatible with the skin lipid layer and can promote the fusion of microcapsules and the stratum corneum through the principle of like dissolves like. The α-pinene component in rosemary essential oil reversibly regulates the density of intercellular lipid arrangement, forming an instantaneous transdermal channel, allowing large molecular active ingredients such as astragalus polysaccharide to break through traditional transdermal restrictions and reach the dermis directly to play a repair role. The proanthocyanidins contained in grape seed oil form an antioxidant synergistic effect with the active ingredients in the oil phase, significantly extending the storage stability of photosensitive ingredients such as shikonin.

[0021] 3. In the active ingredient extraction process, an innovative composite enzymatic hydrolysis strategy is introduced. The synergistic action of cellulase and pectinase directionally cuts the hemicellulose-pectin complex in the plant cell wall, allowing the fat-soluble components (such as angelica volatile oil) encapsulated in the cell to be fully released, while maintaining the stereo conformational activity of green tea polyphenols. By precisely controlling the enzymatic hydrolysis temperature below the critical point of 80°C, the optimal working state of enzyme activity is guaranteed, and the oxidative decomposition of heat-sensitive components such as honeysuckle chlorogenic acid is avoided. The subsequent multi-stage membrane filtration process adopts a pore size gradient decreasing design to gradually screen out plant colloids and macromolecular impurities, so that the active ingredient group is concentrated in the optimal transdermal molecular weight range of 500-3000Da, significantly improving bioavailability.

[0022] 4. The synergistic mechanism of the compound combination is a unique advantage of this regimen. The naphthoquinones in lithospermum erythrorhizon form ionic complexes with calcined gypsum, enhancing the sustained-release properties of the anti-inflammatory active phase. The resin components of frankincense and myrrh undergo eutectic recombination within the microcapsule oil phase, resulting in a biphasic release profile: an initial rapid release to exert an acute anti-inflammatory effect, followed by a later, slower release to maintain therapeutic concentrations. The free radical scavenging network constructed by green tea polyphenols and chrysanthemum flavonoids achieves antioxidant synergy through dual mechanisms of electron transfer and hydrogen atom donation, effectively blocking the UV-induced oxidative stress chain reaction.

[0023] 5. Innovations in formulation technology have resulted in significant clinical adaptability. The shear-responsive nature of the microcapsules triggers targeted release when mechanical forces act on areas of skin friction (such as the elbows). This on-demand delivery model better meets dynamic treatment needs than the continuous penetration of traditional ointments. The moisture-regulating function of the sodium alginate gel is achieved through the reversible hydration of the carboxyl groups, locking in moisture in dry environments to maintain a moist healing environment and expanding the network pores in humid conditions to promote exudate absorption.

[0024] 6. This technical solution offers outstanding advantages in terms of eco-friendliness. By replacing organic solvent extraction with bio-enzymatic hydrolysis, the risk of residual benzene solvents is completely eliminated, while reducing chemical waste discharge by over 90%. The microencapsulation process locks toxic ingredients like raw white atractylodes into the core oil phase, reducing epidermal contact toxicity through a dual barrier (oil encapsulation and gel fixation). The biodegradable properties of sodium alginate and plant essential oils ensure the formulation's environmental compatibility. DETAILED DESCRIPTION

[0025] The following is a clear and complete description of the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts are within the scope of protection of the present invention.

[0026] In this application, the sources of various raw materials are briefly described as follows:

[0027] Lithium, angelica, angelica dahurica, frankincense, myrrh, green tea, raw white atractylodes, white bombyx batryticatus, astragalus, honeysuckle, chrysanthemum, anemarrhena, and calcined gypsum: all purchased from Anhui Bozhou Qiancao Pharmaceutical Co., Ltd., and the medicinal material grade is in line with the first-class products of the 2020 edition of the "Chinese Pharmacopoeia". Among them, frankincense and myrrh are processed by vinegar roasting, and calcined gypsum is obtained by calcining and quenching raw gypsum.

[0028] Sweet almond oil: purchased from Hubei Zhongxin Biotechnology Co., Ltd., CAS No. 8007-69-0, model is food grade cold-pressed oil, acid value ≤2mgKOH / g.

[0029] Grape seed oil: purchased from Jiaxing Huaken Organic Products Co., Ltd., CAS No. 84929-27-1, model is cosmetic grade supercritical extraction oil.

[0030] Rosemary essential oil: purchased from Naturex SA, France, CAS No. 8000-25-7, model is an antioxidant essential oil, the main component of which is eucalyptol ≥35%.

[0031] Sodium alginate: purchased from Qingdao Mingyue Seaweed Group Co., Ltd., CAS No. 9005-38-3, model LM-20, viscosity 200±50 mPa·s (1% aqueous solution).

[0032] Span 85: purchased from Liaoning Shanhe Biotechnology Co., Ltd., CAS No. 26266-57-9, model is pharmaceutical excipient grade, HLB value is 1.8.

[0033] Cellulase and pectinase: purchased from Ningxia Xiasheng Industrial Group Co., Ltd., complex enzyme model SBE-03C, including cellulase CAS No. 9012-54-8, enzyme activity ≥ 20000U / g; pectinase CAS No. 9032-75-1, enzyme activity ≥ 50000U / g.

[0034] Calcium chloride: purchased from Sinopharm Chemical Reagent Co., Ltd., CAS No. 10043-52-4, model is analytical grade AR, content ≥ 96%.

[0035] The technical solution of the present application is: a compound lithospermum seaweed gel preparation capable of improving skin problems, the preparation comprising a carrier and an active ingredient connected thereto, the carrier being a sodium alginate gel matrix, the active ingredient comprising a flavored lithospermum paste mixture, the flavored lithospermum paste mixture being in the form of microcapsules, wherein the oil phase encapsulates the flavored lithospermum paste mixture as the aqueous phase; the flavored lithospermum paste mixture comprises the following raw materials: lithospermum, angelica, angelica dahurica, frankincense, myrrh, green tea, raw white atractylodes, white silkworm, astragalus, honeysuckle, chrysanthemum, anemarrhena, and calcined gypsum.

[0036] Calculated by mass, the ratio of each raw material in the modified lithospermum paste mixture is: 8-12 parts of lithospermum, 5-8 parts of angelica, 4-7 parts of angelica dahurica, 3-5 parts of frankincense, 3-5 parts of myrrh, 6-9 parts of green tea, 2-4 parts of raw white atractylodes, 3-6 parts of white bombyx batryticatus, 7-10 parts of astragalus, 6-9 parts of honeysuckle, 5-8 parts of chrysanthemum, 4-7 parts of anemarrhena, and 3-6 parts of calcined gypsum.

[0037] The preparation method of the modified lithospermum paste mixture comprises the following steps: grinding raw materials into 60-mesh particles, mixing the raw materials with deionized water in a ratio of 1:8-10 based on the total mass, extracting the raw materials in an 80°C water bath for 2 hours, performing primary filtration through a 200-mesh filter cloth and fine filtration through a 0.45-μm microporous filter membrane, and adding a complex enzyme in an amount of 0.1% of the total mass of the raw materials during the extraction process, wherein the complex enzyme consists of cellulase and pectinase of equal mass.

[0038] The oil phase in the microcapsules includes sweet almond oil, grape seed oil, and rosemary essential oil, wherein the mass ratio of the sweet almond oil, grape seed oil, and rosemary essential oil is 3-5:1-2:1.

[0039] The preparation method of the microcapsule is as follows: adding a microcapsule emulsion to a sodium alginate solution, wherein the volume ratio of the microcapsule emulsion to the sodium alginate solution is 1:20-22, stirring at 700 rpm for 1-15 minutes, washing with double distilled water 2-3 times, and then storing in a 0.24g / L calcium chloride solution to obtain microcapsules. The preparation method of the microcapsule emulsion is as follows: stirring 11-13 parts by mass of the oil phase and 15-17 parts by mass of Span 85 emulsifier at 60°C and 800 rpm for 1 minute, adding 2-4 parts of the aqueous phase and 3-5 parts of the 0.24g / L calcium chloride solution, and continuing to stir for 2 minutes to form an emulsion, thereby obtaining a microcapsule emulsion. The sodium alginate solution is prepared by the following method: dissolving 10 grams of sodium alginate in 1 liter of double distilled water, stirring at 500 rpm for 6 hours, and then standing at 4°C for 24 hours to obtain a sodium alginate solution.

[0040] The technical solution of the present invention is further illustrated by the following examples and comparative examples, but the protection scope of the present invention is not limited thereto.

[0041] Example 1

[0042] To prepare the compound lithospermum seaweed gel preparation, the ingredients in the modified lithospermum paste mixture were selected by weight: 12 parts lithospermum, 6.5 parts angelica, 4 parts angelica dahurica, 5 parts frankincense, 3 parts myrrh, 9 parts green tea, 4 parts raw white atractylodes root, 6 parts white bombyx batryticatus, 10 parts astragalus, 9 parts honeysuckle, 8 parts chrysanthemum, 4 parts rhizome of anemarrhena, and 6 parts calcined gypsum. The ingredients were ground into 60-mesh granules and mixed with deionized water at a ratio of 1:10 based on the total weight. Extraction was performed in an 80°C water bath for 2 hours. During the extraction, a complex enzyme was added at 0.1% of the total weight of the raw materials, consisting of equal amounts of cellulase and pectinase. The extract was filtered through a 200-mesh filter cloth and then a 0.45 μm microporous membrane to obtain a clarified extract.

[0043] The microcapsule oil phase consisted of sweet almond oil, grapeseed oil, and rosemary essential oil in a mass ratio of 5:1:1. 13 parts by mass of the oil phase and 17 parts by mass of Span 85 emulsifier were stirred at 60°C and 800 rpm for 1 minute. Subsequently, 4 parts of the aqueous phase and 5 parts of a 0.24 g / L calcium chloride solution were added, and stirring continued for 2 minutes to form an emulsion. The microcapsule emulsion was added to a sodium alginate solution at a volume ratio of 1:22 and stirred at 700 rpm for 15 minutes. The mixture was washed three times with deionized water and then stored in a 0.24 g / L calcium chloride solution to form microcapsules with a diameter of approximately 200 μm. The sodium alginate solution was prepared by dissolving 10 g of sodium alginate in 1 liter of deionized water, stirring at 500 rpm for 6 hours, and then standing at 4°C for 24 hours. The microcapsules were finally dispersed in the gel matrix to form a uniform, transparent gel formulation.

[0044] Example 2

[0045] The raw material ratio of the modified lithospermum paste mixture is 8 parts of lithospermum, 8 parts of angelica, 7 parts of angelica dahurica, 3 parts of frankincense, 5 parts of myrrh, 6 parts of green tea, 2 parts of raw white rhizome, 3 parts of white bombyx batryticatus, 7 parts of astragalus, 6 parts of honeysuckle, 5 parts of chrysanthemum, 7 parts of rhizome of anemarrhena, and 3 parts of calcined gypsum. After the raw materials are crushed, they are mixed with deionized water in a ratio of 1:8 by total weight. The extraction conditions and the addition of complex enzymes are the same as those in Example 1. The microcapsule oil phase mass ratio is 3:2:1 (sweet almond oil: grape seed oil: rosemary essential oil). 11 parts by mass of the oil phase and 15 parts by mass of Span 85 emulsifier are prepared as in Example 1. The emulsion is then mixed with a sodium alginate solution in a volume ratio of 1:20, stirred for 1 minute, and washed twice. The sodium alginate solution preparation parameters are the same as in Example 1. The resulting microcapsules have a particle size of approximately 150 μm.

[0046] Example 3

[0047] The raw material ratios were 10 parts lithospermum erythrorhizon, 5 parts angelica sinensis, 5.5 parts angelica dahurica, 4 parts frankincense, 4 parts myrrh, 7.5 parts green tea, 3 parts raw rhizome of white atractylodes root, 4.5 parts white bombyx batryticatus, 8.5 parts astragalus root, 7.5 parts honeysuckle, 6.5 parts chrysanthemum, 5.5 parts rhizome of anemarrhena, and 4.5 parts calcined gypsum. The water-to-material ratio was 1:9, and the oil phase weight ratio was 4:1.5:1. To prepare the microcapsule emulsion, 3 parts aqueous phase and 4 parts calcium chloride solution were added, mixed with sodium alginate solution in a volume ratio of 1:21, and stirred for 8 minutes. Other steps were consistent with those in Example 1, and the average microcapsule particle size was 180 μm.

[0048] The preparations obtained in the three examples were analyzed and tested, and the results are shown in Table 1.

[0049] Table 1 Performance test results

[0050]

[0051] The above is a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. A compound lithospermum officinale seaweed gel preparation capable of improving skin problems, characterized in that: The preparation comprises a carrier and an active ingredient connected thereto, wherein the carrier is a sodium alginate gel matrix, the active ingredient comprises a flavored lithospermum paste mixture, and the flavored lithospermum paste mixture exists in the form of microcapsules, wherein the oil phase encapsulates the flavored lithospermum paste mixture as a water phase; the flavored lithospermum paste mixture comprises the following raw materials: lithospermum, angelica, angelica dahurica, frankincense, myrrh, green tea, raw white rhizome, white bombyx batryticatus, astragalus, honeysuckle, chrysanthemum, rhizoma anemarrhenae, and calcined gypsum.

2. The compound lithospermum officinale seaweed gel preparation capable of improving skin problems according to claim 1, characterized in that: Calculated by mass, the ratio of each raw material in the modified lithospermum paste mixture is: 8-12 parts of lithospermum, 5-8 parts of angelica, 4-7 parts of angelica dahurica, 3-5 parts of frankincense, 3-5 parts of myrrh, 6-9 parts of green tea, 2-4 parts of raw white atractylodes, 3-6 parts of white bombyx batryticatus, 7-10 parts of astragalus, 6-9 parts of honeysuckle, 5-8 parts of chrysanthemum, 4-7 parts of anemarrhena, and 3-6 parts of calcined gypsum.

3. The compound lithospermum officinale seaweed gel preparation capable of improving skin problems according to claim 1, characterized in that: The preparation method of the modified lithospermum paste mixture comprises the following steps: grinding raw materials into 60-mesh particles, mixing the raw materials with deionized water in a ratio of 1:8-10 based on the total mass, extracting the raw materials in an 80°C water bath for 2 hours, performing primary filtration through a 200-mesh filter cloth and fine filtration through a 0.45-μm microporous filter membrane, and adding a complex enzyme in an amount of 0.1% of the total mass of the raw materials during the extraction process, wherein the complex enzyme consists of cellulase and pectinase of equal mass.

4. The compound lithospermum officinale seaweed gel preparation capable of improving skin problems according to claim 1, characterized in that: The oil phase in the microcapsule comprises sweet almond oil, grape seed oil and rosemary essential oil.

5. The compound lithospermum officinale seaweed gel preparation capable of improving skin problems according to claim 4, characterized in that: The mass ratio of the sweet almond oil, grape seed oil and rosemary essential oil is 3-5:1-2:

1.

6. The compound lithospermum officinale seaweed gel preparation capable of improving skin problems according to claim 1, characterized in that: The preparation method of the microcapsule comprises: adding a microcapsule emulsion to a sodium alginate solution, wherein the volume ratio of the microcapsule emulsion to the sodium alginate solution is 1:20-22, stirring at 700 rpm for 1-15 minutes, washing with double distilled water 2-3 times, and then storing in a 0.24 g / L calcium chloride solution to obtain the microcapsule.

7. The compound lithospermum officinale seaweed gel preparation capable of improving skin problems according to claim 6, characterized in that: The microcapsule emulsion is prepared by stirring 11-13 parts by mass of an oil phase and 15-17 parts by mass of a Span 85 emulsifier at 60° C. and 800 rpm for 1 minute, adding 2-4 parts of an aqueous phase and 3-5 parts of a 0.24 g / L calcium chloride solution, and continuing to stir for 2 minutes to form an emulsion. The result is the microcapsule emulsion.

8. The compound lithospermum officinale seaweed gel preparation capable of improving skin problems according to claim 6, characterized in that: The sodium alginate solution is prepared by the following method: 10 g of sodium alginate is dissolved in 1 liter of double-distilled water, stirred at 500 rpm for 6 hours, and then allowed to stand at 4° C. for 24 hours to obtain the sodium alginate solution.

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