Cleaning and repairing shampoo containing plant saponin foaming agent and preparation method thereof

Abstract

The invention relates to the field of traditional Chinese medicine daily chemical products, and provides cleaning and repairing shampoo based on plant saponin and a preparation method of the cleaning and repairing shampoo. According to the shampoo, soapnut saponin, tea saponin and saponin are compounded to serve as a core foaming agent, traditional Chinese medicine active ingredients such as cacumen biotae extract, polygonum multiflorum polysaccharide and curcumin lipidosome are matched, and the shampoo is prepared through a low-temperature step-by-step emulsification technology. The product keeps the safety of natural components, and solves the technical problems of poor stability and insufficient cleaning power of plant saponin foam. The traditional Chinese medicine active components synergistically act on scalp hair follicles to achieve dual effects of cleaning and repairing, and the shampoo is especially suitable for repairing hair damage caused by long-term chemical dyeing and perming.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine daily chemical products, and in particular to a cleaning and repairing shampoo containing a plant saponin foaming agent and a preparation method thereof. Background Art

[0002] Current shampoo products commonly use chemically synthesized surfactants as cleansing ingredients. While these surfactants produce rich foam, long-term use can disrupt the scalp's microbiome, leading to thinning of the stratum corneum and increased water loss. People with sensitive scalps, in particular, often experience adverse reactions such as itching and redness. Traditional chemical cleansing systems struggle to achieve both cleaning power and mildness.

[0003] Natural plant saponins have attracted attention as alternative cleansers, but they have significant drawbacks: single saponins have weak foaming power and rapid foam dissipation; they easily precipitate when combined with conditioning ingredients; and their active ingredients are susceptible to degradation at conventional preparation temperatures. Existing technologies have yet to address the stability issues of plant saponin systems in shampoo products, and there is also a lack of effective synergistic solutions with active ingredients from traditional Chinese medicines. Summary of the Invention

[0004] The purpose of this section is to summarize some aspects of the embodiments of the present invention and briefly introduce some preferred embodiments. Some simplifications or omissions may be made in this section and the abstract and title of this application to avoid obscuring the purpose of this section, the abstract and the title of the invention, and such simplifications or omissions should not be used to limit the scope of the present invention.

[0005] In view of the above problems in the prior art, the inventors proposed the present invention.

[0006] Therefore, the object of the present invention is to overcome the deficiencies in the prior art and provide a cleaning and repairing shampoo containing a plant saponin foaming agent and a preparation method thereof.

[0007] To solve the above technical problems, the present invention provides the following technical solution: a cleaning and repairing shampoo containing a plant saponin foaming agent, comprising the following components in percentage by mass: 5-8% of a plant saponin composite foaming agent, 6-12% of a traditional Chinese medicine active composition, 3-8% of a hair conditioner, 0.5-2% of a viscosity regulator, 0.1-0.5% of a chelating agent, 0.3-0.8% of a preservative, 0.1-0.3% of a pH regulator, and the balance being deionized water;

[0008] The plant saponin composite foaming agent is composed of soapberry saponin, tea saponin and saponin;

[0009] The traditional Chinese medicine active composition consists of Platycladus orientalis leaf extract, Polygonum multiflorum polysaccharide and curcumin liposome.

[0010] As a preferred embodiment of the cleaning and repairing shampoo containing a plant saponin foaming agent described in the present invention, the mass ratio of soapberry saponin, tea saponin and saponin in the plant saponin composite foaming agent is (4-6):(2-3):(1-2).

[0011] As a preferred embodiment of the cleaning and repairing shampoo containing a plant saponin foaming agent of the present invention, the Chinese medicinal active composition contains 3-5% Platycladus orientalis leaf extract, 2-4% Polygonum multiflorum polysaccharide, and 1-3% curcumin liposome.

[0012] As a preferred embodiment of the cleaning and repairing shampoo containing a plant saponin foaming agent of the present invention, the hair conditioning agent is selected from at least two of cationic guar gum, polyquaternium-7, and panthenol.

[0013] As a preferred embodiment of the cleaning and repairing shampoo containing a plant saponin foaming agent of the present invention, the viscosity modifier is xanthan gum or carbomer, and the chelating agent is disodium EDTA.

[0014] A method for preparing a cleaning and repairing shampoo containing a plant saponin foaming agent, comprising the following steps:

[0015] (1) mixing the plant saponin composite foaming agent with 60-65° C. deionized water to form a base liquid;

[0016] (2) adding the active Chinese medicine composition to the base liquid and emulsifying under vacuum conditions at 50-55° C.;

[0017] (3) Cooling to 38-42°C and adding hair conditioner;

[0018] (4) adding an aqueous solution of a viscosity modifier and a chelating agent;

[0019] (5) Adjust the pH to 5.5-6.5 with a pH regulator, add preservatives, and homogenize and fill.

[0020] As a preferred embodiment of the method for preparing a cleaning and repairing shampoo containing a plant saponin foaming agent according to the present invention, the emulsification time in step (2) is 20-30 minutes, and the vacuum degree is maintained at -0.06 to -0.08 MPa.

[0021] As a preferred embodiment of the method for preparing a cleaning and repairing shampoo containing a plant saponin foaming agent according to the present invention, the homogenization pressure in step (5) is 20-30 MPa, and the homogenization cycle is 2-3 times.

[0022] As a preferred embodiment of the method for preparing the cleaning and repairing shampoo containing a plant saponin foaming agent according to the present invention, the temperature during the preparation process does not exceed 55°C.

[0023] The invention provides an application of the cleaning and repairing shampoo containing a plant saponin foaming agent in repairing damaged hair and maintaining the scalp.

[0024] The present invention's beneficial effects: By combining soapberry saponins, tea saponins, and saponins in specific ratios, this product forms a stable micellar structure, achieving a long-lasting, dense foam at a low dosage, with cleaning power approaching that of chemical surfactants. The triple saponin combination remains stable in weakly acidic environments, avoiding the hydrolysis drawback of traditional saponin systems and significantly extending the product's shelf life.

[0025] Active ingredients from traditional Chinese medicines and a saponin system enhance synergy: Platycladus orientalis leaf extract promotes blood circulation in the scalp, Polygonum multiflorum polysaccharides form a protective film on the hair surface, and curcumin liposomes target and repair damaged hair follicles. These ingredients, thanks to a specialized preparation process, maintain their activity, achieving a triple benefit of cleansing, nourishing, and conditioning hair, with a particularly significant effect on repairing chemically damaged hair. DETAILED DESCRIPTION

[0026] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific implementation methods of the present invention are described in detail below in conjunction with the embodiments of the specification.

[0027] In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention may also be implemented in other ways different from those described herein. Those skilled in the art may make similar generalizations without violating the connotation of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0028] Secondly, the term "one embodiment" or "embodiment" herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The phrase "in one embodiment" appearing in various places throughout this specification does not necessarily refer to the same embodiment, nor does it constitute a separate or selective embodiment that is mutually exclusive with other embodiments.

[0029] Example 1

[0030] This embodiment provides a cleaning and repairing shampoo containing a plant saponin foaming agent and a preparation method thereof.

[0031] Specifically, the formula composition:

[0032] Plant saponin composite foaming agent: soapberry saponin (Xi'an Lvyuan, purity 82%) 4.5%, tea saponin (Hunan Jinhao, content 65%) 2.0%, saponin (Yunnan Tianbao, extract 70%) 1.0%;

[0033] Active ingredients of traditional Chinese medicine: ethanol extract of Platycladus orientalis leaves (from Shanghai, total flavonoids 35%) 4.0%, Polygonum multiflorum polysaccharide (homemade, molecular weight 20 kDa) 3.0%, curcumin liposomes (soybean lecithin carrier, encapsulation efficiency 93%) 1.5%;

[0034] Hair conditioning agent: cationic guar gum (Rhodia JC-HP) 2.5%, panthenol (DSM) 1.2%;

[0035] Auxiliary components: xanthan gum (Fufeng) 0.8%, disodium EDTA 0.3%, phenoxyethanol 0.6%, citric acid 0.2%, and deionized water to make up 100%.

[0036] Preferably, the preparation process is:

[0037] Formation of base solution: Add soapberry saponin, tea saponin and saponin into 52℃ deionized water and stir at 800r / min for 15min to form a uniform colloidal solution;

[0038] Active ingredient loading: Add the ethanol extract of Platycladus orientalis leaves and Polygonum multiflorum polysaccharide and emulsify at -0.07 MPa vacuum and 50°C for 25 minutes. Furthermore, this step was carried out under nitrogen protection, and the dissolved oxygen detection value was ≤1.8 ppm.

[0039] Liposome embedding: cool down to 40°C at a gradient of 1.5°C / min, add curcumin liposomes, cationic guar gum, and panthenol, and maintain stirring for 12 min;

[0040] Viscosity adjustment: Pre-disperse xanthan gum in 3 times the amount of glycerol and add it together with disodium EDTA aqueous solution (5% concentration) into the system;

[0041] pH adjustment and stabilization: adjust the pH to 6.0±0.1 with citric acid, add phenoxyethanol and then pass through a 25MPa homogenizer for two cycles;

[0042] Aging and filling: Aging at 28℃ for 24 hours before filling.

[0043] Example 2

[0044] This embodiment provides a cleaning and repairing shampoo containing a plant saponin foaming agent and a preparation method thereof.

[0045] As another embodiment, this example optimizes the formula for oily scalp needs:

[0046] Key points for formula adjustment:

[0047] Adjustment of plant saponin ratio: increase tea saponin to 2.8% (using its steroidal structure to regulate sebum activity);

[0048] Replacement of Chinese herbal medicine components: 1.2% Zanthoxylum bungeanum extract (supercritical CO2 extract) was used to replace the same amount of Platycladus orientalis leaf extract;

[0049] Functional additives: add 0.5% tea tree essential oil microcapsules (wall material: β-cyclodextrin);

[0050] Conditioner optimization: Part of the cationic guar gum was replaced with polyquaternium-7 (0.8%).

[0051] Improved preparation method:

[0052] Post-microcapsulation: Tea tree oil microcapsules are added after emulsification is complete (40°C) to prevent high-temperature capsule rupture; Polysaccharide enzymatic hydrolysis: Polygonum multiflorum polysaccharide is treated with cellulase (40°C, pH 5.0, 1h) to reduce the molecular weight to 8-10kDa to enhance scalp permeability;

[0053] Enhanced homogenization: The homogenization pressure is increased to 28MPa to eliminate the aggregation of microcapsules.

[0054] Effect verification data:

[0055] Oil control performance: After 4 weeks of use, 30 subjects showed that the scalp oil secretion decreased from the baseline value of 180±35μg / cm 2 Reduced to 106±28μg / cm 2 (p<0.01);

[0056] Anti-dandruff effect: dandruff coverage rate decreased from 23.5% to 4.2%;

[0057] Foam stability: The foam residual rate measured by Roche foam instrument after 5 minutes was 85.3%.

[0058] Example 3

[0059] This embodiment provides a cleaning and repairing shampoo containing a plant saponin foaming agent and a preparation method thereof.

[0060] As a preferred embodiment, this embodiment strengthens the hair follicle repair function:

[0061] Recipe-specific design:

[0062] Traditional Chinese medicine synergistic components: 1.0% of angelica water extract (ferulic acid ≥ 1.2%) and 0.5% of ginsenoside Rb1 (purity 98%);

[0063] Carrier optimization: Curcumin liposomes were increased to 2.0% and modified with biotin-PEG2000 (targeting hair follicle stem cells);

[0064] Penetration enhancer: Add 0.3% of Azone (to enhance the percutaneous absorption of saponin components).

[0065] Key preparation processes:

[0066] Saponin-saponin complex formation: Ginsenoside Rb1 and plant saponin were premixed (molar ratio 1:8) and aged at 60 °C for 30 min;

[0067] Cooling was performed in stages: 55°C → 45°C (rate 1°C / min) → 38°C (rate 0.5°C / min) to maintain the integrity of the liposome bilayer structure;

[0068] Targeted modification: Biotin-PEG2000 was inserted into the preformed liposome membrane by post-insertion method, with a modification density of 350-400 molecules / liposome;

[0069] Prolonged aging: After homogenization, age at 30°C in the dark for 48 hours to stabilize the system viscosity at 8500±300 cP.

[0070] Biological Validation:

[0071] Hair follicle cell experiment: Human dermal papilla cells were cultured in vitro and added with 0.1% shampoo extract:

[0072] Cell proliferation rate↑58.7%;

[0073] The Bcl-2 / Bax ratio was upregulated 2.3-fold;

[0074] Clinical trial: 45 patients with androgenic alopecia (grade II-III) used daily:

[0075] Hair density increased by 19.8 hairs / cm in 28 days 2 ;

[0076] The tensile test showed a 41.3% reduction in hair loss.

[0077] In summary, the core of the present invention lies in the construction of a "plant saponin-traditional Chinese medicine active ingredient" binary synergistic system, whose mechanism of action stems from the combination of the "monarch, minister, assistant and envoy" compatibility concept in traditional Chinese medicine and modern colloid chemistry. The plant saponin composite foaming agent, as the "monarch drug", undertakes the cleaning function. The triterpene hydrophobic skeleton of soapberry saponin penetrates grease and dirt, the steroidal structure of tea saponin enhances the elasticity of the foam liquid film, and the polysaccharide hydrophilic chain of saponin stabilizes the system through a hydrogen bond network. The mixed micelles formed by the three (dynamic light scattering confirms a particle size of 80-150nm) not only reduce the critical micelle concentration but also form a "vesicle-lamellar" multiphase structure at the microscopic level, providing carrier space for the active ingredients of traditional Chinese medicine. Platycladus orientalis leaf extract, as the "minister drug", plays a role in guiding the meridians. The quercetin aglycone contained in it can specifically bind to scalp keratin, guiding the targeted delivery of Polygonum multiflorum polysaccharides and curcumin to hair follicles. This synergistic combination of components breaks through the shackles of traditional natural shampoo products, which are "weak cleaning and scattered efficacy", and achieves the unified functions of cleansing and repairing.

[0078] The low-temperature step-by-step emulsification process used in the examples is essentially a modern interpretation of the principle of "maintaining efficacy and reducing losses" for traditional Chinese medicine preparations. Plant saponins are prone to glycosidic bond cleavage in an environment >60°C, resulting in a decrease in foaming power (thermogravimetric analysis shows that the weight loss rate increases by 3 times at 70°C); and the flavonoids in Platycladus orientalis leaves are sensitive to oxidation, and conventional open emulsification will cause the content of isoquercetin to drop by more than 40%. The present invention solves this problem through triple control: a vacuum environment (-0.06 to -0.08 MPa) reduces the dissolved oxygen to below 2 ppm, blocking the free radical chain reaction; a gradient cooling program (1-2°C / min) avoids the phase transition critical point (42°C) of curcumin liposomes; and inert gas protection maintains the three-dimensional configuration of heat-sensitive ingredients such as ginsenosides. In particular, in the preparation of biotin-PEG modified liposomes in Example 3, the post-insertion method avoids the destruction of the activity of the targeting molecule by high temperature, thereby improving the efficiency of hair follicle delivery.

[0079] Furthermore, Example 1 establishes a basic framework to demonstrate the universality of the plant saponin system in conventional hair care; Example 2 targets the pathogenesis of "seborrheic scalp" and introduces pepperamide and tea tree essential oil to form a synergistic anti-dandruff mechanism - pepperamide blocks the TRPV1 receptor to relieve itching, and terpinen-4-ol in tea tree essential oil destroys the β-glucan structure of the Malassezia biofilm, which is highly consistent with the traditional Chinese medicine principle of "clearing heat and drying dampness"; Example 3 focuses on the "blood deficiency and hair loss" syndrome, angelica extract promotes scalp capillary regeneration, and ginsenoside Rb1 upregulates the expression of β-catenin, a key protein in the Wnt pathway of hair papilla cells, reflecting the wisdom of "invigorating qi and promoting hair growth".

[0080] This plan fully considers the feasibility of production conversion. The raw materials for plant saponins are bulk agricultural and sideline products such as soapberry and camellia seed meal. The effective components can be obtained through conventional alcohol extraction, which is in line with the concept of recycling resources of traditional Chinese medicine; the process parameters are set in the range of 50-55°C, which is compatible with existing emulsification equipment and does not require the transformation of the production line; the preservative system adopts a combination of phenoxyethanol / ethylhexyl glycolic acid, which can inhibit microorganisms at a rate of up to 99.8% in a weakly acidic environment, meeting the three-year shelf life requirement. Especially in terms of quality control, with foam stability (5min residual rate>80%) and active ingredient retention rate (accelerated test>95%) as core indicators, a natural product evaluation system that is different from chemical shampoos is established. This technical design from laboratory to workshop enables the product to have both high innovation and industrial promotion.

[0081] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the spirit and scope of the technical solutions of the present invention, which should all be included in the scope of the claims of the present invention.

Claims

1. A cleaning and repairing shampoo containing a plant saponin foaming agent, characterized in that: The invention is composed of the following components in percentage by mass: 5-8% of a plant saponin composite foaming agent, 6-12% of a traditional Chinese medicine active composition, 3-8% of a hair conditioner, 0.5-2% of a viscosity regulator, 0.1-0.5% of a chelating agent, 0.3-0.8% of a preservative, 0.1-0.3% of a pH regulator, and the balance being deionized water; The plant saponin composite foaming agent is composed of soapberry saponin, tea saponin and saponin; The traditional Chinese medicine active composition consists of Platycladus orientalis leaf extract, Polygonum multiflorum polysaccharide and curcumin liposome.

2. The cleaning and repairing shampoo containing a plant saponin foaming agent according to claim 1, characterized in that: The mass ratio of soapberry saponin, tea saponin and saponin in the plant saponin composite foaming agent is (4-6):(2-3):(1-2).

3. The cleaning and repairing shampoo containing a plant saponin foaming agent according to claim 2, characterized in that: The active Chinese medicinal composition contains 3-5% of Platycladus orientalis leaf extract, 2-4% of Polygonum multiflorum polysaccharide and 1-3% of curcumin liposome.

4. The cleaning and repairing shampoo containing a plant saponin foaming agent according to claim 1, characterized in that: The hair conditioning agent is selected from at least two of cationic guar gum, polyquaternium-7, and panthenol.

5. The cleaning and repairing shampoo containing a plant saponin foaming agent according to claim 1, characterized in that: The viscosity regulator is xanthan gum or carbomer, and the chelating agent is disodium EDTA.

6. A method for preparing a cleaning and repairing shampoo containing a plant saponin foaming agent according to any one of claims 1 to 5, characterized in that: The following steps are involved: (1) mixing the plant saponin composite foaming agent with 60-65° C. deionized water to form a base liquid; (2) adding the active Chinese medicine composition to the base liquid and emulsifying under vacuum conditions at 50-55° C.; (3) Cooling to 38-42°C and adding hair conditioner; (4) adding an aqueous solution of a viscosity modifier and a chelating agent; (5) Adjust the pH to 5.5-6.5 with a pH regulator, add preservatives, and homogenize and fill.

7. The method for preparing a cleaning and repairing shampoo containing a plant saponin foaming agent according to claim 1, wherein: The emulsification time in step (2) is 20-30 minutes, and the vacuum degree is maintained at -0.06 to -0.08 MPa.

8. The method for preparing a cleaning and repairing shampoo containing a plant saponin foaming agent according to claim 1, characterized in that: The homogenization pressure in step (5) is 20-30 MPa, and the homogenization cycle is 2-3 times.

9. The method for preparing a cleaning and repairing shampoo containing a plant saponin foaming agent according to claim 1, wherein: The temperature during the preparation process does not exceed 55°C.

10. Use of the cleaning and repairing shampoo containing a plant saponin foaming agent as claimed in claim 1 in repairing damaged hair and caring for the scalp.