Skin-care hand sanitizer and preparation method thereof

Abstract

The invention discloses a skin-care hand sanitizer and a preparation method thereof, and relates to the technical field of sanitizers. According to the technical scheme, the cleaning agent is composed of the following components in percentage by mass: 1-5% of an emulsifier; 1-5% of an oil phase; 2-8% of a skin care component; 0.6%-3.5% of a sterilization component; 0.5%-2.5% of an improved film forming agent; 0.1 to 0.8 percent of a synergistic thickening agent; 0.05%-0.3% of a rheology modifier; 0.2 to 1% of organic modified clay; 0.5-2% of skin feeling adjusting powder; 1-3% of volatile silicone oil; 1-5% of an acid-base regulator; and the balance of water. The skin-care hand sanitizer prepared by the invention has the intelligent rheological characteristics of being stable in standing, smooth in rubbing and fresh and cool after being dried, and the skin-care hand sanitizer has an extremely skin feeling, and the effect is far better than that of a product obtained by simple mixing; and through a series of working procedures with a synergistic effect, the two long-standing technical problems of production efficiency and product skin feeling are successfully solved at the same time.

Description

Technical Field

[0001] The present invention relates to the technical field of disinfectants, in particular to a skin-protection hand disinfectant and a preparation method thereof. Background Art

[0002] In healthcare settings, frequent hand hygiene (such as handwashing and the use of alcohol-based disinfectants) is a key measure to prevent the spread of disease. However, the frequent use of alcohol-based disinfectants by healthcare workers can damage the skin barrier, leading to dryness, cracking, itching, and even dermatitis. Therefore, incorporating skincare functions into hand hygiene (such as using hand sanitizers or disinfectants containing moisturizing and repairing ingredients) is crucial.

[0003] Currently, disinfectant products containing moisturizers such as glycerin and sodium hyaluronate have emerged on the market to address skin problems. However, to suspend these ingredients and maintain system stability, large amounts of thickeners or film-forming agents (such as carbomer and HEC) are typically required, followed by prolonged stirring to achieve full swelling and hydration. This production process can take up to 4-6 hours, resulting in low production efficiency and increased costs. More importantly, while high-viscosity products offer excellent stability, they can also cause users to experience a heavy, sticky feeling, high resistance during application, and difficulty rubbing. Furthermore, they can also leave a strong filmy feel and lack of air permeability after use. Traditional products often exhibit poor immediate skin feel. For example, Chinese invention patent CN114306149A discloses a wash-free, antibacterial skin-care disinfectant gel and its preparation method. Using triethanolamine and carbomer for thickening, this method still suffers from the long time required for carbomer thickening. Furthermore, the high amount of carbomer used inevitably results in a heavy, sticky feeling and poor rubbing properties, without fundamentally improving the user experience. Therefore, the market urgently needs an efficient skin care disinfectant product that can be produced quickly and provide a refreshing, smooth and pleasant skin feel. Summary of the Invention

[0004] The technical problem to be solved by the present invention is to overcome the shortcomings of the existing technology and provide a skin-protecting hand disinfectant and a preparation method thereof. The prepared skin-protecting hand disinfectant has intelligent rheological properties such as stability when standing, smoothness when rubbed, and refreshing after drying, as well as an ultimate skin feel, and its effect is far superior to that of products obtained by simple mixing. Moreover, through a series of synergistic processes, the two long-standing technical problems of production efficiency and product skin feel are successfully solved at the same time.

[0005] The technical solution of the present invention is: In one aspect, the present invention provides a skin-protection hand disinfectant comprising the following components in percentage by mass: Emulsifier: 1-5%; Oil phase: 1-5%; Skin care ingredients: 2-8%; Bactericidal ingredients: 0.6-3.5%; Improved film-forming agent: 0.5-2.5%; Synergistic thickener: 0.1-0.8%; Rheology modifier: 0.05-0.3%; Organic modified clay: 0.2-1%; Skin feel adjustment powder: 0.5-2%; Volatile silicone oil: 1-3%; Acid-base regulator: 1-5%; The rest is water; The bactericidal component is one of 0.5-3% chlorhexidine gluconate, benzalkonium chloride, benzalkonium bromide, didecyldimethylammonium chloride and para-chloro-metaxylenol and 0.1-0.5% ε-polylysine; the synergistic thickener is a cross-linked polymer of acrylate and C10-30 alkyl acrylate in a mass ratio of (1-4):1.

[0006] Preferably, the emulsifier is glyceryl monostearate, polyglyceryl-3 diisostearate or lanolin alcohol.

[0007] Preferably, the oil phase is glyceryl stearate, capric triglyceride or isopropyl myristate.

[0008] Preferably, the skin care ingredient is one or more of glycerin, sodium hyaluronate, squalane, PEG-7 glyceryl cocoate and allantoin.

[0009] Preferably, the improved film-forming agent is hydrophobically modified hydroxyethyl cellulose; the rheology regulator is sodium magnesium silicate; and the organically modified clay is stearalkonium chloride bentonite.

[0010] Preferably, the skin feel regulating powder is boron nitride or silica; the volatile silicone oil is cyclopentasiloxane; and the acid-base regulator is sodium hydroxide, potassium hydroxide or triethanolamine.

[0011] In another aspect, the present invention provides a method for preparing the above-mentioned skin-protection hand disinfectant, comprising the following steps: S1 Preparation of aqueous base: Add 60-70 wt.% of water to the main reactor A and start stirring; add the synergistic thickener to the main reactor A and continue stirring to fully wet and disperse it without fish eyes or lumps; S2 instant activation thickening: Use the remaining water to prepare an acid-base regulator aqueous solution, and add it dropwise to the system within 2-4 minutes to adjust the pH of the system to 6.2-6.8. The system will become a gel base within 60-120 seconds. S3 Dissolve the main ingredients: Add the improved film-forming agent to the gel base and stir until it is completely dissolved. The high viscosity of the gel base can effectively prevent the light powder from flying and clumping. Then add the skin care ingredients and the bactericidal ingredients in sequence and stir until they are completely dissolved. S4 rheology adjustment: add rheology modifier and stir to fully hydrate and gel to obtain water phase; Preparation of S5 oil phase: Add the emulsifier and 0.5-3% of the oil phase by weight to reactor B. Heat to 58-62°C using a stepwise heating method, maintain the temperature and stir for 3-7 minutes, then continue heating to 76-80°C and stirring at 1000-1500 rpm for 3-5 minutes until the system becomes a transparent and uniform oil phase liquid. S6 Emulsification: The water phase in the main reactor A is cooled to 42-48°C and stirred. The oil phase liquid in the reactor B is injected into the water phase online through a pipeline shear emulsifier. This process ensures that the oil phase liquid is instantly sheared into micron-sized droplets to obtain a preliminary oil-in-water (O / W) emulsion. S7 Intelligent Rheology and Skin Feel Construction: Transfer the emulsion to a scraper-type stirred kettle and cool to 36-38°C. Add the pre-prepared organically modified clay pregel, which is prepared by stirring and dispersing the organically modified clay with the remaining oil phase. Then, stir at 40-60 rpm for 15-20 minutes. Under the same stirring conditions, add the skin feel adjustment powder and continue stirring for 20-30 minutes. S8 blending: cool the system to 26-30°C, add volatile silicone oil, and stir to make it evenly dispersed to obtain a skin care hand disinfectant.

[0012] Preferably, in step S1, the stirring speed is 450-550 rpm, and stirring is continued for 8-12 minutes after the synergistic thickener is added.

[0013] Preferably, in step S3, the stirring speed is 550-650 rpm, and the stirring time is 15-25 min; in step S4, the stirring speed is 800-1000 rpm, and the stirring time is 12-18 min.

[0014] Preferably, in step S6, the stirring speed is 600-800 rpm and the shear rate is 10000-15000 s -1 ; In step S7, the stirring speed during dispersion is 3000-4000rpm, and the stirring time is 8-12min; in step S8, the stirring speed is 30-50rpm, and the stirring time is 5-8min.

[0015] The mechanism of changes in the internal composition and skin feel of the skin-protecting hand disinfectant prepared by the present invention during storage, use, and post-use is as follows: Phase 1: Static Storage The synergistic thickener in skin-care hand sanitizers forms a weak network structure, acting as a synergistic building block. The rheology modifier provides stabilizing points, enhancing system stability. The organically modified clay builds a "house of cards" structure, serving as the main framework. Together, these components form a stable three-dimensional network that suspends and immobilizes the modified film-forming agent and skin-care ingredients, ensuring their stable encapsulation.

[0016] Stage 2: Kneading (applying shear force) The "House of Cards" structure instantly disintegrates under the action of shear force, resulting in a sharp drop in viscosity (shear thinning); the polymer network is oriented, allowing the volatile silicone oil to spread rapidly, bringing an instantaneous extremely smooth and easy-to-rub skin feel; at the same time, the skin feel regulating powder begins to adsorb, providing a lasting effect for the subsequent skin feel.

[0017] Stage 3: After kneading is completed (shear force disappears) Volatile silicone oil evaporates completely, leaving a refreshing, matte, non-greasy skin feel; the "House of Cards" structure is quickly rebuilt and the viscosity is instantly restored, ensuring that the product does not flow and is long-lasting and stable; the improved film-forming agent forms a protective film, providing long-lasting moisturizing and protective barrier; the polymer network restores entanglement, assisting in stabilizing the overall structure.

[0018] Compared with the prior art, the present invention has the following beneficial effects: 1. This invention constructs an oil-in-water (O / W) emulsion system with an alcohol-free bactericidal ingredient as its core, integrating an "intelligent rheological system" and a "skin feel optimization system." The intelligent rheological system, composed of an improved film-forming agent, a synergistic thickener, a rheology modifier, and an organically modified clay, achieves instant thickening and aging-free stability during production, significantly shortening the production cycle. The skin feel optimization system, composed of an organically modified clay, a volatile silicone oil, and a skin feel-modifying powder, imparts the product with intelligent properties: stability when standing, smooth when rubbed, and a refreshing feel after drying. The resulting hand disinfectant not only meets the standards of "GB 27950-2020 General Requirements for Hand Disinfectants," but also offers significant skincare benefits and an excellent user experience.

[0019] 2. This invention utilizes "instant gelation" technology: leveraging the rapid response of synergistic thickeners at a specific pH, it constructs a high-viscosity gel base within 2 minutes, replacing the traditional hours-long wait and improving production efficiency. This invention achieves "low-temperature precision emulsification": by controlling the aqueous phase temperature (42-48°C) and utilizing in-line shearing, emulsification is completed at temperatures far lower than the 70-80°C of traditional processes, significantly reducing energy consumption and protecting heat-sensitive ingredients in hand sanitizers. This invention also utilizes "clay pre-dispersion" technology: pre-dispersing the organically modified clay in the oil phase of the formulation itself, completely eliminating the problem of agglomeration and difficulty in uniform dispersion when directly added to the aqueous phase. This is key to achieving stable and uniform rheological properties. Furthermore, this invention utilizes a "ripening-free" process: through the synergistic combination of synergistic thickeners, rheology modifiers, and organically modified clay, a stable three-dimensional network structure is formed immediately after emulsification, eliminating the 24-48 hours of aging required by traditional processes and significantly shortening the process time. In addition, the addition of volatile silicone oil and skin feel regulating powder to the hand disinfectant of the present invention makes the sticky feeling of the product basically disappear within 1 minute after use, presenting a matte, dry, velvety touch.

[0020] 3. The present invention solves three core problems existing in existing hand disinfectants (especially those with high skin care ingredient content): (1) the problem of dry and allergic skin caused by alcohol ingredients; (2) the problem that the thickening and emulsification process in traditional production processes takes too long (up to several hours); and (3) the problem that the product has a high viscosity in pursuit of stability, resulting in stickiness, difficulty in rubbing, and poor skin feel during use. The skin care hand disinfectant prepared by the present invention has intelligent rheological properties of being stable when standing, smooth when rubbed, and refreshing after drying, as well as an ultimate skin feel, and its effect is far superior to products obtained by simple mixing. Moreover, the preparation method of the present invention is not a simple combination of conventional steps, but through a series of synergistic processes, it successfully solves the two long-standing technical problems of production efficiency and product skin feel. DETAILED DESCRIPTION

[0021] In order to enable those skilled in the art to better understand the technical solutions of the present invention, the technical solutions of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention.

[0022] Example 1 The skin care hand disinfectant of this embodiment is composed of the following components in percentage by mass: 1% glyceryl monostearate, 1% glyceryl stearate, 5% glycerol, 0.5% sodium hyaluronate, 1% squalane, 2% benzalkonium chloride, 0.3% ε-polylysine, 0.5% hydrophobically modified hydroxyethyl cellulose, 0.05% acrylate, 0.05% C10-30 alkyl acrylate crosspolymer Pemulen TR-2, 0.05% sodium magnesium silicate, 0.2% stearalkonium chloride bentonite, 0.5% boron nitride, 1% cyclopentasiloxane, 1.5% potassium hydroxide, and the remainder is deionized water.

[0023] The preparation method of the skin-protection hand disinfectant of this embodiment comprises the following steps: S1 Preparation of the aqueous base: Add 63 wt.% deionized water to the main reactor A and stir at 500 rpm. Add Pemulen TR-2, a crosslinked polymer of acrylate and C10-30 alkyl acrylate, to the main reactor A and stir for 10 minutes to ensure full wet dispersion without fish eyes or lumps. S2 instantaneous activation thickening: Use the remaining deionized water to prepare an aqueous solution of potassium hydroxide, and add it dropwise to the main reactor A within 3 minutes. The pH of the system is adjusted to 6.5, and the system becomes a gel base within 90 seconds. S3 Dissolve the main components: Add hydrophobically modified hydroxyethyl cellulose to the gel base and stir at 600 rpm for 20 minutes until dissolved; then add glycerin, sodium hyaluronate, squalane, benzalkonium chloride, and ε-polylysine in sequence and stir at 600 rpm for a total of 25 minutes; S4 rheological adjustment: add sodium magnesium silicate and stir at 900 rpm for 15 min to fully hydrate and gel to obtain an aqueous phase; Preparation of S5 oil phase: Glyceryl monostearate and glyceryl stearate (0.5% by weight of the total glyceryl stearate) were added to reactor B. The mixture was heated to 60°C using a stepwise heating method, stirred at this temperature for 5 minutes, and then heated to 78°C and stirred at 1200 rpm for 4 minutes to obtain a transparent and uniform oil phase liquid. S6 Emulsification: The water phase in the main reactor A was cooled to 45°C and stirred at 700 rpm; the oil phase in the reactor B was emulsified by a pipeline shear emulsifier (12000s -1 ) is injected into the aqueous phase online to obtain an emulsion; S7 Intelligent Rheology and Skin Feel Construction: The emulsion was transferred to a scraper-type stirred kettle and cooled to 37°C. A pre-prepared organically modified clay pregel (stearalkonium chloride bentonite and the remaining glyceryl stearate were stirred and dispersed at 3500 rpm for 8 minutes) was added and stirred at 50 rpm for 18 minutes to achieve uniform dispersion. Under the same stirring conditions, boron nitride was added and stirred for 25 minutes to ensure that the powder was completely wetted and dispersed, with no visible particles. S8 blending: cool the system to 28°C, add cyclopentasiloxane, and stir at 40 rpm for 7 minutes to uniformly disperse it to obtain a skin care hand disinfectant.

[0024] Example 2 The skin care hand disinfectant of this embodiment is composed of the following components in percentage by mass: 3% polyglyceryl-3 diisostearate, 3% isopropyl myristate, 2% squalane, 1% PEG-7 glyceryl cocoate, 0.2% allantoin, 1.5% chlorhexidine gluconate, 0.5% ε-polylysine, 2.5% hydrophobically modified hydroxyethyl cellulose, 0.6% acrylate, 0.2% Pemulen TR-2 (C10-30 alkyl acrylate crosspolymer), 0.3% sodium magnesium silicate, 1% stearalkonium chloride bentonite, 2% silica, 3% cyclopentasiloxane, 5% triethanolamine, and the remainder is deionized water.

[0025] The preparation method of the skin-protection hand disinfectant of this embodiment comprises the following steps: S1. Preparation of aqueous base: Add 60 wt.% deionized water to the main reactor A and stir at 550 rpm. Add Pemulen TR-2, a crosslinked polymer of acrylate and C10-30 alkyl acrylate, to the main reactor A and stir for 8 minutes to ensure full wet dispersion without fish eyes or lumps. S2 instantaneous activation thickening: triethanolamine was prepared into an aqueous solution with the remaining deionized water and added dropwise to the main reactor A within 2 minutes. The pH of the system was adjusted to 6.2, and the system became a gel base within 60 seconds. S3 Dissolve the main components: Add hydrophobically modified hydroxyethyl cellulose to the gel base and stir at 650 rpm for 15 minutes until dissolved; then add squalane, PEG-7 glyceryl cocoate, allantoin, chlorhexidine gluconate, and ε-polylysine in sequence and stir at 650 rpm for a total of 20 minutes; S4 rheological adjustment: sodium magnesium silicate was added and stirred at 1000 rpm for 12 min to fully hydrate and gel to obtain an aqueous phase; Preparation of S5 oil phase: Polyglyceryl-3 diisostearate and isopropyl myristate (3% by weight of the total isopropyl myristate) were added to reactor B. The mixture was heated to 62°C using a stepwise heating method, stirred at this temperature for 3 minutes, and then heated to 80°C and stirred at 1500 rpm for 3 minutes to obtain a transparent and uniform oil phase liquid. S6 Emulsification: The water phase in the main reactor A was cooled to 42°C and stirred at 800 rpm; the oil phase in the reactor B was emulsified by a pipeline shear emulsifier (15000s -1 ) is injected into the aqueous phase online to obtain an emulsion; S7 Intelligent Rheology and Skin Feel Construction: The emulsion was transferred to a scraper-type stirred kettle and cooled to 36°C. A pre-prepared organically modified clay pregel (made by stirring and dispersing stearalkonium chloride bentonite and the remaining isopropyl myristate at 4000 rpm for 8 minutes) was added and stirred at 60 rpm for 15 minutes to achieve uniform dispersion. Under the same stirring conditions, silica was added and stirring continued for 20 minutes to ensure that the powder was completely wetted and dispersed, with no visible particles. S8 blending: cool the system to 26°C, add cyclopentasiloxane, and stir at 50 rpm for 5 minutes to uniformly disperse it to obtain a skin care hand disinfectant.

[0026] Example 3 The skin care hand disinfectant of this embodiment is composed of the following components in percentage by mass: 5% lanolin alcohol, 5% capric triglyceride, 7.9% glycerol, 0.1% allantoin, 3% benzalkonium bromide, 0.1% ε-polylysine, 1.5% hydrophobically modified hydroxyethyl cellulose, 0.3% acrylate, 0.1% Pemulen TR-2 (C10-30 alkyl acrylate crosspolymer), 0.15% sodium magnesium silicate, 0.6% stearalkonium chloride bentonite, 1.2% boron nitride, 2% cyclopentasiloxane, 3% sodium hydroxide, and the remainder is deionized water.

[0027] The preparation method of the skin-protection hand disinfectant of this embodiment comprises the following steps: S1 Preparation of the aqueous base: Add 65 wt.% deionized water to the main reactor A and stir at 450 rpm. Add Pemulen TR-2, a crosslinked polymer of acrylate and C10-30 alkyl acrylate, to the main reactor A and stir for 12 minutes to ensure full wetness and dispersion without fish eyes or lumps. S2 instantaneous activation thickening: use the remaining deionized water to prepare an aqueous solution of sodium hydroxide, and add it dropwise to the main reactor A within 4 minutes, adjust the pH of the system to 6.8, and the system will become a gel base within 120 seconds; S3 Dissolve the main components: Add hydrophobically modified hydroxyethyl cellulose to the gel base and stir at 550 rpm for 25 minutes until dissolved; then add glycerol, allantoin, benzalkonium bromide, and ε-polylysine in sequence and stir at 550 rpm for a total of 30 minutes; S4 rheological adjustment: sodium magnesium silicate was added and stirred at 800 rpm for 18 min to fully hydrate and gel to obtain an aqueous phase; Preparation of S5 oil phase: Lanolin alcohol and 0.5% capric triglyceride by weight of the total capric triglyceride were added to reactor B. Using a stepwise heating method, the mixture was first heated to 58°C, stirred at this temperature for 7 minutes, and then heated to 76°C and stirred at 1000 rpm for 5 minutes to obtain a transparent and uniform oil phase liquid. S6 Emulsification: The water phase in the main reactor A was cooled to 48°C and stirred at 600 rpm; the oil phase in the reactor B was emulsified by a pipeline shear emulsifier (10000s -1 ) is injected into the aqueous phase online to obtain an emulsion; S7 Intelligent Rheology and Skin Feel Construction: The emulsion was transferred to a scraper-type stirred kettle and cooled to 38°C. A pre-prepared organically modified clay pregel (made by stirring and dispersing stearalkonium chloride bentonite and residual capric triglyceride at 3000 rpm for 12 minutes) was added and stirred at 40 rpm for 20 minutes to achieve uniform dispersion. Under the same stirring conditions, boron nitride was added and stirred for 30 minutes to ensure that the powder was completely wetted and dispersed, with no visible particles. S8 blending: cool the system to 30°C, add cyclopentasiloxane, and stir at 30 rpm for 8 minutes to uniformly disperse it to obtain a skin care hand disinfectant.

[0028] Example 4 The skin care hand disinfectant of this embodiment is composed of the following components in percentage by mass: 1% glyceryl monostearate, 1% glyceryl stearate, 2% glycerol, 0.5% para-chloro-metaxylenol, 0.1% ε-polylysine, 0.5% hydrophobically modified hydroxyethyl cellulose, 0.075% acrylate, 0.025% Pemulen TR-2 (C10-30 alkyl acrylate crosspolymer), 0.05% sodium magnesium silicate, 0.2% stearalkonium chloride bentonite, 0.5% silica, 1% cyclopentasiloxane, 1% potassium hydroxide, and the remainder is deionized water.

[0029] The preparation method of the skin-protection hand disinfectant of this embodiment comprises the following steps: S1 Preparation of the aqueous base: Add 60 wt.% deionized water to the main reactor A and stir at 500 rpm. Add Pemulen TR-2, a crosslinked polymer of acrylate and C10-30 alkyl acrylate, to the main reactor A and stir for 10 minutes to ensure full wet dispersion without fish eyes or lumps. S2 instantaneous activation thickening: Use the remaining deionized water to prepare an aqueous solution of potassium hydroxide, and add it dropwise to the main reactor A within 2 minutes. The pH of the system is adjusted to 6.2, and the system becomes a gel base within 60 seconds. S3 Dissolve the main components: Add hydrophobically modified hydroxyethyl cellulose to the gel base and stir at 600 rpm for 20 minutes until dissolved; then add glycerol, parachloro-metaxylenol, and ε-polylysine in sequence and stir at 600 rpm for a total of 25 minutes; S4 rheological adjustment: add sodium magnesium silicate and stir at 900 rpm for 15 min to fully hydrate and gel to obtain an aqueous phase; Preparation of S5 oil phase: Glyceryl monostearate and glyceryl stearate (2% by weight of the total glyceryl stearate) were added to reactor B. The mixture was heated to 60°C using a stepwise heating method, stirred at this temperature for 3 minutes, and then heated to 76°C and stirred at 1200 rpm for 4 minutes to obtain a transparent and uniform oil phase liquid. S6 Emulsification: The water phase in the main reactor A was cooled to 42°C and stirred at 600 rpm; the oil phase in the reactor B was emulsified by a pipeline shear emulsifier (10000s -1 ) is injected into the aqueous phase online to obtain an emulsion; S7 Intelligent Rheology and Skin Feel Construction: The emulsion was transferred to a scraper-type stirred kettle and cooled to 37°C. A pre-prepared organically modified clay pregel (made by stirring and dispersing stearalkonium chloride and the remaining glyceryl stearate at 3000 rpm for 10 minutes) was added and stirred at 50 rpm for 18 minutes to achieve uniform dispersion. Under the same stirring conditions, silica was added and stirred for 25 minutes to ensure that the powder was completely wetted and dispersed, with no visible particles. S8 blending: cool the system to 28°C, add cyclopentasiloxane, and stir at 40 rpm for 7 minutes to uniformly disperse it to obtain a skin care hand disinfectant.

[0030] Example 5 The skin care hand disinfectant of this embodiment is composed of the following components in percentage by mass: 5% polyglyceryl-3 diisostearate, 5% isopropyl myristate, 3% squalane, 3% PEG-7 glyceryl cocoate, 0.2% allantoin, 3% didecyldimethylammonium chloride, 0.5% ε-polylysine, 2.5% hydrophobically modified hydroxyethyl cellulose, 0.4% acrylate, 0.4% Pemulen TR-2 (C10-30 alkyl acrylate crosspolymer), 0.3% sodium magnesium silicate, 1% stearalkonium chloride bentonite, 2% boron nitride, 3% cyclopentasiloxane, 5% triethanolamine, and the remainder is deionized water.

[0031] The preparation method of the skin-protection hand disinfectant of this embodiment comprises the following steps: S1 Preparation of the aqueous base: Add 70% deionized water to the main reactor A and stir at 550 rpm. Add Pemulen TR-2, a crosslinked polymer of acrylate and C10-30 alkyl acrylate, to the main reactor A and stir for 12 minutes to ensure full wetness and dispersion without fish eyes or lumps. S2 instantaneous activation thickening: triethanolamine was prepared into an aqueous solution with the remaining deionized water and added dropwise to the main reactor A within 2 minutes. The pH of the system was adjusted to 6.8, and the system became a gel base within 120 seconds. S3 Dissolve the main ingredients: Add hydrophobically modified hydroxyethyl cellulose to the gel base and stir at 650 rpm for 25 minutes until dissolved; then add squalane, PEG-7 glyceryl cocoate, allantoin, didecyldimethylammonium chloride, and ε-polylysine in sequence and stir at 650 rpm for a total of 25 minutes; S4 rheological adjustment: sodium magnesium silicate was added and stirred at 1000 rpm for 18 min to fully hydrate and gel to obtain an aqueous phase; Preparation of S5 oil phase: Polyglyceryl-3 diisostearate and 0.5% isopropyl myristate by weight of the total isopropyl myristate were added to reactor B. Using a stepwise heating method, the mixture was first heated to 62°C, stirred at this temperature for 7 minutes, and then heated to 80°C and stirred at 1500 rpm for 5 minutes to obtain a transparent and uniform oil phase liquid. S6 Emulsification: The water phase in the main reactor A was cooled to 48°C and stirred at 800 rpm; the oil phase in the reactor B was emulsified by a pipeline shear emulsifier (15000s -1 ) is injected into the aqueous phase online to obtain an emulsion; S7 Intelligent Rheology and Skin Feel Construction: The emulsion was transferred to a scraper-type stirred kettle and cooled to 38°C. A pre-prepared organically modified clay pregel (made by stirring and dispersing stearalkonium chloride bentonite and the remaining isopropyl myristate at 4000 rpm for 12 minutes) was added and stirred at 50 rpm for 20 minutes to ensure uniform dispersion. Under the same stirring conditions, boron nitride was added and stirred for 30 minutes to ensure that the powder was completely wetted and dispersed, with no visible particles. S8 blending: cool the system to 28°C, add cyclopentasiloxane, and stir at 50 rpm for 8 minutes to uniformly disperse it to obtain a skin care hand disinfectant.

[0032] Comparative Example 1 The difference from Example 1 is that in the skin-protection hand disinfectant, an equal amount of water is used to replace the acrylate and C10-30 alkanol acrylate cross-linked polymer Pemulen TR-2.

[0033] Comparative Example 2 The difference from Example 1 is that in the skin-protection hand disinfectant, an equal amount of acrylate is used to replace the C10-30 alkyl acrylate cross-linked polymer Pemulen TR-2.

[0034] Comparative Example 3 The difference from Example 1 is that in the skin-protection hand disinfectant, an equal amount of C10-30 alkyl acrylate cross-linked polymer Pemulen TR-2 is used to replace acrylate.

[0035] Comparative Example 4 The difference from Example 1 is that in the skin care hand disinfectant, an equal amount of water is used to replace stearalkonium chloride bentonite.

[0036] Comparative Example 5 The difference from Example 1 is that in the skin-care hand disinfectant, an equal amount of water is used to replace sodium magnesium silicate.

[0037] Comparative Example 6 The difference from Example 1 is that in the skin-care hand disinfectant, an equal amount of benzalkonium chloride is used to replace ε-polylysine.

[0038] Comparative Example 7 The difference from Example 1 is that in step S5, a one-step heating method is used instead of a step heating method to directly heat the reactor B to 78°C.

[0039] Comparative Example 8 The difference from Example 1 is that in step S6, the oil phase liquid in the reactor B is directly added to the water phase without shearing through the pipeline shear emulsifier.

[0040] The hand disinfectants prepared in Examples 1-5 and Comparative Examples 1-8 were subjected to bactericidal effect tests and field tests. The tests were conducted with reference to "GB 27950-2020 General Requirements for Hand Disinfectants" and "WS / T 10009 Test Methods for Disinfectant Products". The test results are shown in Table 1: Table 1 Bactericidal effect test and field test results of the hand disinfectants prepared in Examples 1-5 and Comparative Examples 1-8

[0041] The production efficiency and product quality of Examples 1-5 and Comparative Examples 1-8 are shown in Table 2: Table 2 Production efficiency and product quality of Examples 1-5 and Comparative Examples 1-8

[0042] As can be seen in Table 1, the hand disinfectant products of Examples 1-5 and Comparative Examples 1-8 all exhibited excellent bacterial killing effects. However, Comparative Example 6, which lacked the bactericidal ingredient ε-polylysine, exhibited significantly lower logarithmic killing values ​​against Pseudomonas aeruginosa and Candida albicans than Example 1, demonstrating that ε-polylysine, when combined with other cationic bactericides, exhibits a key synergistic effect against fungi and Gram-negative bacteria.

[0043] As shown in Table 2, Examples 1-5 achieved instant thickening (<2 minutes) and no aging. Comparative Examples 2-3, using a single thickener, resulted in prolonged thickening times and required aging, demonstrating that the specific blend of synergistic thickeners employed in the present invention is key to achieving rapid production. Furthermore, delamination was observed in the products of Comparative Example 5, which lacked a rheology modifier, Comparative Example 7, which employed a one-step heating method, and Comparative Example 8, which lacked shear injection. This demonstrates that the rheology modifier, the step-by-step heating method for emulsification, and the shear injection process employed in the present invention are essential for forming a stable emulsion structure.

[0044] Table 2 also shows that the products of Examples 1-5 exhibit low shear viscosity and excellent freshness. However, Comparative Example 4, which lacks stearalkonium chloride bentonite, results in poor dispersion of boron nitride, resulting in a very poor skin feel and high shear viscosity. Comparative Examples 2, 3, and 5, due to poorly constructed rheological systems, exhibit high shear viscosity and a strong sticky feel. This demonstrates that the synergy of the components in the intelligent rheological system of the present invention is key to achieving a "statically thick, dynamically thin" skin feel.

[0045] Furthermore, Examples 1-5 used a pipeline shear emulsifier when injecting the oil phase into the water phase, resulting in a relatively fine product with a particle size of 1-10 μm. Comparative Example 8, however, did not use a pipeline shear emulsifier, resulting in a product with a particle size of 50-100 μm and a rough, granular appearance.

Claims

1. A skin-protection hand disinfectant, characterized in that: The following components are present in the following mass percentages: composition: Emulsifier: 1-5%; Oil phase: 1-5%; Skin care ingredients: 2-8%; Bactericidal ingredients: 0.6-3.5%; Improved film-forming agent: 0.5-2.5%; Synergistic thickener: 0.1-0.8%; Rheology modifier: 0.05-0.3%; Organic modified clay: 0.2-1%; Skin feel adjustment powder: 0.5-2%; Volatile silicone oil: 1-3%; Acid-base regulator: 1-5%; The rest is water; The bactericidal component is one of 0.5-3% chlorhexidine gluconate, benzalkonium chloride, benzalkonium bromide, didecyldimethylammonium chloride and para-chloro-metaxylenol and 0.1-0.5% ε-polylysine; the synergistic thickener is a cross-linked polymer of acrylate and C10-30 alkyl acrylate in a mass ratio of (1-4):

1.

2. The skin-protecting hand disinfectant according to claim 1, wherein The emulsifier is glyceryl monostearate, polyglyceryl-3 diisostearate or lanolin alcohol.

3. The skin-protection hand disinfectant according to claim 1, characterized in that: The oil phase is glyceryl stearate, capric triglyceride or isopropyl myristate.

4. The skin-protection hand disinfectant according to claim 1, wherein The skin care ingredients are one or more of glycerin, sodium hyaluronate, squalane, PEG-7 glyceryl cocoate and allantoin.

5. The skin-protection hand disinfectant according to claim 1, characterized in that: The improved film-forming agent is hydrophobically modified hydroxyethyl cellulose; the rheology regulator is sodium magnesium silicate; and the organic modified clay is stearalkonium chloride bentonite.

6. The skin-protection hand disinfectant according to claim 1, characterized in that: The skin feel regulating powder is boron nitride or silica; the volatile silicone oil is cyclopentasiloxane; and the acid-base regulator is sodium hydroxide, potassium hydroxide or triethanolamine.

7. The method for preparing the skin-protection hand disinfectant according to any one of claims 1 to 6, wherein: The following steps are involved: S1 Preparation of aqueous base: Add 60-70 wt.% of water to the main reactor A and start stirring; add the synergistic thickener to the main reactor A and continue stirring to fully wet and disperse it; S2 instant activation thickening: Use the remaining water to prepare an acid-base regulator aqueous solution, and add it dropwise to the system within 2-4 minutes to adjust the pH of the system to 6.2-6.

8. The system will become a gel base within 60-120 seconds. S3 Dissolve the main ingredients: Add the improved film-forming agent to the gel base and stir until it is completely dissolved; Then add the skin care ingredients and bactericidal ingredients in sequence and stir until completely dissolved; S4 rheology adjustment: add rheology modifier and stir to fully hydrate and gel to obtain water phase; Preparation of S5 oil phase: Add the emulsifier and 0.5-3% of the oil phase by weight to reactor B. Heat to 58-62°C using a stepwise heating method, maintain the temperature and stir for 3-7 minutes, then continue heating to 76-80°C and stirring at 1000-1500 rpm for 3-5 minutes until the system becomes a transparent and uniform oil phase liquid. S6 Emulsification: Cool the water phase in the main reactor A to 42-48°C and stir; inject the oil phase liquid in the reactor B into the water phase online through a pipeline shear emulsifier to obtain an emulsion; S7 Intelligent Rheology and Skin Feel Construction: Transfer the emulsion to a scraper-type stirred kettle and cool to 36-38°C. Add the pre-prepared organically modified clay pregel, which is prepared by stirring and dispersing the organically modified clay with the remaining oil phase. Then, stir at 40-60 rpm for 15-20 minutes. Under the same stirring conditions, add the skin feel adjustment powder and continue stirring for 20-30 minutes. S8 blending: cool the system to 26-30°C, add volatile silicone oil, and stir to make it evenly dispersed to obtain a skin care hand disinfectant.

8. The method for preparing the skin-protection hand disinfectant according to claim 7, wherein: In step S1, the stirring speed is 450-550 rpm, and stirring is continued for 8-12 minutes after the synergistic thickener is added.

9. The method for preparing the skin-protection hand disinfectant according to claim 7, wherein: In step S3, the stirring speed is 550-650 rpm, and the stirring time is 15-25 min; in step S4, the stirring speed is 800-1000 rpm, and the stirring time is 12-18 min.

10. The method for preparing the skin-protection hand disinfectant according to claim 7, wherein: In step S6, the stirring speed is 600-800 rpm and the shear rate is 10000-15000 s -1 ; In step S7, the stirring speed during dispersion is 3000-4000rpm, and the stirring time is 8-12min; in step S8, the stirring speed is 30-50rpm, and the stirring time is 5-8min.

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