Sputum enrichment device and sputum enrichment method

Abstract

The invention relates to the field of medical detection instruments, and discloses a sputum enrichment device and a sputum enrichment method. The sputum enrichment device comprises a cup body, a negative pressure assembly, a liquid storage cover and an enrichment membrane assembly. One end of the cup body is provided with a liquefaction cavity, and the other end of the cup body is connected with the negative pressure assembly; the liquid storage cover is detachably arranged at one end of the cup body and used for blocking the liquefaction cavity, and a liquid storage cavity used for storing liquid in a sealed mode is formed in the liquid storage cover; the enrichment membrane assembly is arranged on the side, close to the filtering opening, of the liquid storage cover and used for covering the filtering opening; wherein a conducting structure is arranged in the liquefying cavity, and the conducting structure is used for conducting the liquid storage cavity and the liquefying cavity when the enrichment membrane assembly covers the filtering opening. According to the sputum enrichment device, sputum liquefaction treatment and enrichment treatment are integrated, the operation procedure is simplified, the labor intensity and the detection cost are reduced, and the risks of environment pollution caused by leakage and cross infection are avoided.

Description

Technical Field

[0001] The present application relates to the field of medical testing instruments, and in particular, to a sputum enrichment device and a sputum enrichment method. Background Art

[0002] During clinical treatment and disease screening, testing for certain pathogens often requires collecting sputum from patients for testing. Sputum collection typically requires the patient to cough deeply to produce sputum. Medical staff will provide the patient with a container, into which the patient coughs the sputum directly. Sometimes, if the patient is unable to produce sufficient sputum, medical staff may use an endotracheal or gastric tube to extract sputum. After sputum extraction, the sputum is liquefied and then enriched. Finally, the enriched sample is tested.

[0003] However, the sputum processing device provided in the prior art has a simple structure and is only used for the collection and liquefaction of sputum. The sputum enrichment process needs to be transferred to another process, thereby increasing the workload of medical workers, and thus the conditions for efficient processing cannot be achieved. In addition, the transfer process requires the use of disposable pipette tips and pipette guns as well as consumables for storing and transferring samples and reagents, which will also increase the corresponding testing costs; at the same time, in the packaging and transportation process of reagents and consumables before use, there will be corresponding storage, subpackaging, and matching use rules, making the test preparation process relatively cumbersome. In the transfer process, samples and reagents are at risk of leakage and contamination of the environment and cross infection, which will affect the accuracy of the test results and pose a major safety hazard. Summary of the Invention

[0004] The purpose of this application is to provide a sputum enrichment device and a sputum enrichment method to solve the problems of high labor intensity, high detection cost, complex detection process and safety hazards caused by separate operations of sputum liquefaction and enrichment treatment in the existing technology.

[0005] To achieve the above-mentioned purpose, in a first aspect, the present application provides a sputum enrichment device, comprising a cup body, a negative pressure component, a liquid storage cover and an enrichment membrane component;

[0006] One end of the cup body is provided with a liquefaction chamber, and the other end is connected to the negative pressure component, and the liquefaction chamber has a filter port connected to the negative pressure component;

[0007] The liquid storage cover is detachably provided at one end of the cup body for sealing the liquefaction cavity, and the liquid storage cover is provided with a liquid storage cavity for sealing and storing liquid;

[0008] The enrichment membrane assembly is arranged on a side of the liquid storage cover close to the filter port, and is used to cover the filter port;

[0009] Wherein, a conducting structure is provided in the liquefaction chamber, and the conducting structure is used to connect the liquid storage chamber with the liquefaction chamber when the enrichment membrane assembly covers the filter port.

[0010] As a further improvement of the above technical solution:

[0011] In a possible embodiment, the liquid storage cavity has an opening, the opening faces the filter port and is provided with a sealing member;

[0012] Wherein, the conductive structure is used to puncture or scratch the sealing member.

[0013] In a possible embodiment, the liquid storage cover cooperates with the cup body thread pair, the conducting structure is a scratching tooth, and the scratching tooth is provided on the wall of the liquefaction chamber;

[0014] Wherein, the enrichment membrane assembly is used to seal the filter port when the cutting teeth cut through the sealing member.

[0015] In one possible implementation, the liquid storage cap includes:

[0016] A cover body, matched with the threaded pair of the cup body;

[0017] a boss body, disposed on a side of the cover body facing the cup body, the liquid storage cavity being disposed in the boss body, and an opening of the liquid storage cavity being located on an end surface of the boss body; and

[0018] The connecting body is arranged on a side of the cover body facing the cup body and is connected to the enrichment membrane assembly.

[0019] In a possible embodiment, the inner peripheral wall of the cover body is provided with an internal thread, and the outer peripheral wall of the cup body is provided with an external thread matching the internal thread;

[0020] Wherein, the length of the internal thread is greater than the moving stroke of the enrichment membrane assembly covering the filter port.

[0021] In a possible embodiment, the enrichment membrane assembly is connected to the liquid storage cover by heat welding; or the enrichment membrane assembly and the liquid storage cover are an integral injection molding structure;

[0022] Wherein, a breakable connection portion is formed between the enrichment membrane assembly and the liquid storage cover.

[0023] In one possible embodiment, the enrichment membrane assembly includes:

[0024] A membrane frame connected to the liquid storage cover, wherein the membrane frame is provided with a plurality of hollow hole areas; and

[0025] The enrichment filter membrane is arranged on the membrane frame and covers all the hollow hole areas.

[0026] In a possible implementation, a tapered section for guiding flow is provided between the liquefaction chamber and the filter port.

[0027] In a possible embodiment, the other end of the cup body is provided with a piston cavity for accommodating the negative pressure assembly;

[0028] The negative pressure assembly includes a piston rod and a piston rubber head arranged on the piston rod, and the piston rubber head is interference fit with the piston cavity.

[0029] To achieve the above purpose, in a second aspect, the present application further provides a sputum enrichment method, which uses the sputum enrichment device provided according to the first aspect, and the sputum enrichment method comprises:

[0030] S100: loading sputum and liquefaction treatment liquid into the liquid storage cavity of the liquid storage cap, and installing the enrichment membrane assembly;

[0031] S200: Installing the liquid storage cover onto the cup body and assembling the negative pressure assembly;

[0032] S300: Covering the filter port with the enrichment membrane assembly, and then connecting the liquid storage chamber and the liquefaction chamber through a conducting structure, so that the liquid in the liquid storage chamber flows into the liquefaction chamber;

[0033] S400: shaking and mixing the entire sputum enrichment device to fully liquefy the sputum;

[0034] S500: sucking the liquefied liquid in the liquefaction chamber by the negative pressure assembly so that all the liquid passes through the enrichment membrane assembly for enrichment;

[0035] S600: Remove the liquid storage cover, then remove the enrichment membrane assembly, and proceed to the next treatment process.

[0036] Compared with the prior art, the present invention has the following advantages:

[0037] The present application provides a sputum enrichment device and a sputum enrichment method, wherein the sputum enrichment device stores sputum and liquefaction treatment liquid through the liquid storage chamber of the liquid storage cover, and the sputum is preliminarily liquefied in the liquid storage chamber, and then the liquid storage chamber and the liquefaction chamber are connected by the conduction structure, so that the liquid in the liquid storage chamber enters the liquefaction chamber for further liquefaction, at this time, the filter port is covered by the enrichment membrane assembly, and the liquefied liquid in the liquefaction chamber is sucked by the negative pressure assembly so that all the liquid is enriched by the enrichment membrane assembly, and finally the liquid storage cover is removed, and the enrichment membrane assembly that has completed the enrichment is removed to enter the next process. In this way, the sputum enrichment device provided by the present application integrates the sputum liquefaction treatment and enrichment treatment processes, without the need for separate operations, simplifying the operating procedures and processes, greatly reducing labor intensity, and at the same time the entire operation is completed in the liquid storage cover and the cup body, without contact with the outside world, thereby avoiding the risk of leakage pollution and cross infection, and the operation is more convenient, safer and more reliable.

[0038] Other features and advantages of the present application will be described in detail in the subsequent detailed description. BRIEF DESCRIPTION OF THE DRAWINGS

[0039] The accompanying drawings are used to provide a further understanding of the present application and constitute a part of the specification. Together with the following detailed description, they are used to explain the present application. It should be understood that the following drawings only illustrate certain embodiments of the present application and should not be considered as limiting the scope. A person of ordinary skill in the art can also derive other relevant drawings based on these drawings without inventive effort. In the drawings:

[0040] Figure 1 A front view of a sputum enrichment device provided in an embodiment of the present application is shown;

[0041] Figure 2 Shown Figure 1 Cross-sectional view along the AA axis;

[0042] Figure 3 Shown Figure 1 An exploded schematic diagram of the sputum enrichment device shown;

[0043] Figure 4 Shown Figure 3 A schematic diagram of the structure of the liquid storage cover in the sputum enrichment device shown;

[0044] Figure 5 Shown Figure 3 Schematic diagram of the local structure of the connection between the liquid storage cover and the enrichment membrane assembly in the sputum enrichment device shown.

[0045] Description of reference numerals:

[0046] 100, cup body; 110, liquefaction chamber; 111, gradually contracting section; 120, filter port; 130, scoring teeth; 140, external thread; 150, piston chamber; 151, gradually expanding section;

[0047] 200, liquid storage cover; 201, liquid storage chamber; 210, cover body; 211, internal thread; 220, boss body; 221, avoidance hole; 230, connector; 240, sealing member;

[0048] 300, enrichment membrane assembly; 301, connection portion; 310, membrane frame; 311, hollow hole area; 320, vertical pole; 330, enrichment filter membrane;

[0049] 400, negative pressure assembly; 410, piston rod; 420, piston rubber head. DETAILED DESCRIPTION

[0050] The following describes the specific implementation of the embodiment of the present application in detail with reference to the accompanying drawings. It should be understood that the specific implementation described herein is only used to illustrate and explain the embodiment of the present application and is not intended to limit the embodiment of the present application.

[0051] In the embodiments of the present application, it should be understood that the terms "center", "up", "down", "vertical", "horizontal", "top", "inside", "outside", "clockwise", "counterclockwise", etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present application.

[0052] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of the technical features being referred to. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the features. Throughout the description of this application, "plurality" means two or more, unless otherwise specifically defined.

[0053] In this application, unless otherwise expressly specified or limited, terms such as "mounted," "connected," "connect," and "fixed" should be understood in a broad sense. For example, they may refer to fixed connections, detachable connections, or integration; mechanical connections or electrical connections; direct connections or indirect connections through an intermediate medium; and internal connections between two components or interactions between two components. Those skilled in the art will understand the specific meanings of these terms in this application based on specific circumstances.

[0054] The present application will be described in detail below with reference to the accompanying drawings and in conjunction with exemplary embodiments.

[0055] Example

[0056] See also Figure 1 、 Figure 2 and Figure 3 This embodiment provides a sputum enrichment device that can be used for liquefaction of sputum and enrichment treatment after liquefaction.

[0057] The sputum collection device provided in this embodiment includes a cup body 100, a negative pressure assembly 400, a liquid storage cap 200, and an enrichment membrane assembly 300. One end of the cup body 100 is provided with a liquefaction chamber 110, and the other end is connected to the negative pressure assembly 400. The liquefaction chamber 110 has a filter port 120 that communicates with the negative pressure assembly 400. Thus, the negative pressure assembly 400 can draw air from the liquefaction chamber 110 through the filter port 120, creating a negative pressure in the liquefaction chamber 110 and facilitating the rapid flow of liquid from the liquefaction chamber 110 through the filter port 120.

[0058] It should be noted that, in normal use, the cup body 100 has one end of the liquefaction chamber 110 facing upward, and the upper end of the liquefaction chamber 110 is open, so that the liquid stored in the subsequent liquid storage cap 200 can enter the liquefaction chamber 110. Of course, the cup body 100 can also be used at a certain angle.

[0059] A liquid reservoir cap 200 is detachably mounted on one end of the cup body 100 and serves to seal the liquefaction chamber 110. This seals the opening of the liquefaction chamber 110, preventing it from contacting the outside world and contaminating the interior of the liquefaction chamber 110. It also prevents leakage of liquid that has entered the liquefaction chamber 110. Furthermore, the detachable structure facilitates removal and installation of the liquid reservoir cap 200, improving operational convenience.

[0060] The liquid storage cap 200 has a liquid storage cavity 201, which is used to store liquefied liquid and collected sputum (collectively referred to as liquid in this application).

[0061] The enrichment membrane assembly 300 is disposed on a side of the liquid storage cap 200 close to the filter port 120. The enrichment membrane assembly 300 is used to cover the filter port 120 to ensure that the liquid at the filter port 120 can be enriched by the enrichment membrane assembly 300.

[0062] Furthermore, a conductive structure is provided on the inner wall of the liquefaction chamber 110. The conductive structure is used to connect the liquid storage chamber 201 with the liquefaction chamber 110 when the enrichment membrane assembly 300 covers the filter port 120. After the liquid storage chamber 201 and the liquefaction chamber 110 are connected, the liquid in the liquid storage chamber 201 flows into the liquefaction chamber 110, and the liquefaction chamber 110 has a larger space, so that the liquefied liquid stored in the liquid storage chamber 201 and the collected sputum can enter the liquefaction chamber 110 for further mixing and liquefaction.

[0063] In some embodiments, the liquid storage chamber 201 and the liquefaction chamber 110 can be connected via a conductive structure by providing a valve at the opening of the liquid storage chamber 201, with the conductive structure controlling the opening of the valve. Specifically, for example, a magnetically controlled valve can be used to achieve contactless opening. Alternatively, a one-way ball valve can be used, with the cutoff direction directed from the liquid storage chamber 201 to the liquefaction chamber 110. In this way, the ball in the one-way ball valve is lifted by the conductive structure to allow liquid to flow into the liquefaction chamber 110.

[0064] In other embodiments, the conductive structure may also be provided on the liquid reservoir cover 200. Specifically, the conductive structure includes a pressing rod, one end of which is connected to the opening of the liquid reservoir chamber 201 by a spring, and the other end of which extends through the liquid reservoir cover 200 and is exposed to the outside. In this way, by applying pressure to the pressing rod, the pressing rod compresses the spring, thereby releasing the blockage of the opening of the liquid reservoir chamber 201, thereby allowing the liquid reservoir chamber 201 to communicate with the liquefaction chamber 110.

[0065] In this embodiment, the liquid storage chamber 201 is located on the side of the liquid storage cover 200 facing the filter port 120, and the liquid storage chamber 201 extends toward the filter port 120. A sealing member 240 is further provided at the opening of the liquid storage chamber 201, and the sealing member 240 can seal the liquid storage chamber 201. It can be understood that after the liquid storage chamber 201 is pre-loaded with liquefied liquid and sputum, it is sealed by the sealing member 240 to prevent the liquid storage cover 200 from spilling and leaking during movement, thereby avoiding leakage and polluting the environment. When the liquid storage cover 200 is in use, the sealed liquid storage cover 200 is turned over and installed on the cup body 100 so that the sealed opening of the liquid storage chamber 201 faces the filter port 120.

[0066] Furthermore, a conductive structure is provided on the inner wall of the liquefaction chamber 110 for puncturing or scratching the seal 240. The puncturing method may be to use a needle to puncture the seal 240, allowing the liquid in the liquid storage chamber 201 to flow out through the punctured opening. In this embodiment, scratching the seal 240 creates a larger opening in the seal 240, accelerating the outflow of the liquid and ensuring a more complete outflow.

[0067] Specifically, in this embodiment, the liquid storage cap 200 and the cup body 100 are threaded and connected. The structure is a cutting tooth 130, which is arranged on the inner wall of the liquefaction chamber 110. The top and side of the cutting tooth 130 are provided with a blade portion that can cut through the seal 240.

[0068] In this way, by rotating the liquid storage cover 200 , the liquid storage cover 200 can be rotated relative to the cup body 100 and simultaneously moved in the direction of the rotation axis, thereby facilitating the cutting teeth 130 to cut through the sealing member 240 .

[0069] It should be noted that in this embodiment, the enrichment membrane assembly 300 is used to cover the filter port 120 when the cutting teeth 130 cut through the seal 240. In other words, when the cutting teeth 130 cut through the seal 240, the enrichment membrane assembly 300 can form a blockage for the filter port 120 to facilitate subsequent enrichment operations.

[0070] Optionally, the sealing member 240 is a sealing film, wherein the sealing film is preferably an aluminum film or a tin film. Of course, other films that are easy to cut can also be used. It should be understood that the above is only an example and does not limit the scope of protection of this application.

[0071] Optionally, the sealing member 240 seals the opening of the liquid storage chamber 201 by heat welding or bonding, which has the advantages of easy production, high efficiency and good sealing performance.

[0072] In order to more clearly describe the technical solution of the present application, this embodiment describes the various structural components of the sputum enrichment device, as follows:

[0073] See also Figure 2 、 Figure 3 and Figure 4 The liquid storage cover 200 includes a cover body 210, a boss body 220 and a connector 230. The cover body 210 and the cup body 100 are threaded and the cover body 210 can move relative to the cup body 100 in the direction of the rotation axis. The boss body 220 is arranged on the side of the cover body 210 facing the cup body 100. A liquid storage cavity 201 is provided in the boss body 220. The opening of the liquid storage cavity 201 is located on the end face of the boss body 220 (i.e., the end away from the cover body 210). In this way, the opening of the liquid storage cavity 201 can be closer to the blade teeth 130, thereby reducing the rotation stroke of the cover body 210. The connector 230 is arranged on the side of the cover body 210 facing the cup body 100 and is connected to the enrichment membrane assembly 300.

[0074] Furthermore, the cover 210, the boss 220 and the connector 230 are integrally formed, and the connector 230 is located in the middle of the cover 210. The boss 220 is provided with a clearance hole 221 in the middle for circumventing the connector 230. The extension line of the connector 230 passes through the filter port 120.

[0075] In some embodiments, the inner circumferential wall of the lid 210 is provided with an internal thread 211, and the outer circumferential wall of the cup 100 is provided with an external thread 140 that mates with the internal thread 211. Furthermore, the length of the internal thread 211 is greater than the travel distance of the enrichment membrane assembly 300 to cover the filter port 120. Thus, when the lid 210 is tightened, the lid 210 can simultaneously rotate relative to the cup 100 and move along the axis of rotation. By controlling the travel distance of the enrichment membrane assembly 300 according to the tightening travel of the lid 210, a certain degree of synchronization can be ensured between the action of piercing the seal 240 and the action of the enrichment membrane assembly 300 covering the filter port 120.

[0076] Since the length of the internal thread 211 is greater than the moving stroke of the enrichment membrane assembly 300 to cover the filter port 120, sufficient margin can be reserved for the enrichment membrane assembly 300 to cover the filter port 120, so that after the enrichment membrane assembly 300 completes covering the filter port 120, the sealing around the filter port 120 is ensured, preventing liquid from passing through the gap, thereby improving the enrichment effect.

[0077] It is understood that, for example, when the cover 210 is rotated clockwise, the cover 210 moves toward the filter port 120. At this time, the cutting teeth 130 cut through the seal 240, the enrichment membrane assembly 300 covers the filter port 120, and the liquid in the liquid storage chamber 201 flows into the liquefaction chamber 110. When the cover 210 is rotated counterclockwise, the cover 210 moves away from the filter port 120, facilitating the removal of the entire liquid storage cover 200. It should be understood that the clockwise and counterclockwise rotations described above are merely examples and can be interchanged. Therefore, they are not intended to limit the scope of protection of this application.

[0078] In some embodiments, the connector 230 and the enrichment membrane assembly 300 are detachably connected, such as by snap-fitting, interference-fitting, or threaded connection, to facilitate installation and disassembly of the enrichment membrane assembly 300 and reduce the difficulty of disassembly.

[0079] See also Figure 2 、 Figure 4 and Figure 5 In this embodiment, the connector 230 and the enrichment membrane assembly 300 are welded, and a breakable connection portion 301 is formed at the connection between the enrichment membrane assembly 300 and the connector 230, making disassembly simpler and more convenient.

[0080] Specifically, the enrichment membrane assembly 300 includes a membrane frame 310 and an enrichment filter membrane 330. The membrane frame 310 has a vertical rod 320 connected to the connector 230 on the liquid storage cap 200. In this embodiment, the vertical rod 320 and the connector 230 are connected by heat welding, and a notch with stress concentration is formed at the connection, which is the connecting portion 301. In this way, under a certain frequency of vibration, the notch can be broken, thereby achieving the separation of the enrichment membrane assembly 300 from the connector 230. There is no need to use external tools to contact the enrichment membrane assembly 300, which is safe and hygienic, while reducing external interference in subsequent detection.

[0081] In some embodiments, the connector 230 and the membrane frame 310 of the enrichment membrane assembly 300 are integrally injection molded, with a breakable connection 301 formed between the connector 230 and the membrane frame 310. The structure of the breakable connection 301 is similar to the notch formed by a thermal weld and will not be further described here. It is understood that integral injection molding can further improve product yield compared to thermal welding.

[0082] Furthermore, the membrane frame 310 is provided with a plurality of hollowed-out areas 311. The enrichment filter membrane 330 is disposed on the membrane frame 310 and covers all of the hollowed-out areas 311. It will be appreciated that the provision of the plurality of hollowed-out areas 311 allows a support framework to be formed between two adjacent hollowed-out areas 311, thereby better supporting the enrichment filter membrane 330. Furthermore, the hollowed-out areas 311 can increase the filtration area of ​​the enrichment filter membrane 330, thereby improving the permeability of the liquid during filtration.

[0083] In some embodiments, the enrichment filter membrane 330 is adhesively connected to the membrane frame 310 .

[0084] See also Figure 2 and Figure 3 In this embodiment, a tapered section 111 for guiding flow is provided between the liquefaction chamber 110 and the filter port 120. The tapered section 111 is in a frustum shape, realizing the transition from the diameter of the liquefaction chamber 110 to the diameter of the filter port 120, so as to guide and converge the liquid to the filter port 120. Subsequently, suction is performed by the negative pressure component 400, so that all the liquid can pass smoothly through the enrichment filter membrane 330 located at the filter port 120.

[0085] Furthermore, the other end of the cup body 100 is provided with a piston chamber 150 for accommodating the negative pressure assembly 400. The negative pressure assembly 400 includes a piston rod 410 and a piston rubber head 420 arranged on the piston rod 410, and the piston rubber head 420 is interference fit with the piston chamber 150. In the initial state, the head of the piston rubber head 420 abuts against the liquid outlet side of the filter port 120 to seal the filter port 120 and prevent the liquid in the liquefaction chamber 110 from entering the piston chamber 150. During suction, the rubber head is driven by the piston rod 410 to move away from the filter port 120. At this time, negative pressure is formed in the liquefaction chamber 110. When all the liquid in the liquefaction chamber 110 is drawn into the piston chamber 150 through the enrichment filter membrane 330, the enrichment of sputum is completed.

[0086] It can be understood that after the sputum enrichment is completed, the entire liquid storage cap 200 can be removed, and the enrichment membrane assembly 300 will be taken out together with the liquid storage cap 200, and then the enrichment membrane assembly 300 will be separated from the liquid storage cap 200, and then the enrichment membrane assembly 300 will be processed in the next step, for example, the enrichment membrane assembly 300 will be placed in a cell preservation solution for the next step of processing.

[0087] In some embodiments, a gradually expanding section 151 is formed between the piston cavity 150 and the filter port 120. The gradually expanding section 151 is also frustoconical in shape, and the piston rubber head 420 has a structure that is compatible with the gradually expanding section 151. This reduces the movement resistance of the piston rubber head 420 in the piston cavity 150, facilitating the installation and advancement of the piston rubber head 420. Furthermore, in the initial state, the piston rubber head 420 and the piston cavity 150 are better fitted, improving the sealing performance, thereby preventing the liquid in the liquefaction chamber 110 from directly entering the piston cavity 150.

[0088] See also Figures 1 to 5 Furthermore, this embodiment also provides a sputum enrichment method, which uses the sputum enrichment device provided in this embodiment. In this embodiment, the sputum enrichment method includes the following steps:

[0089] S100: Sputum and liquefaction treatment liquid are loaded into the liquid storage cavity 201 of the liquid storage cap 200, and the enrichment membrane assembly 300 is installed.

[0090] Specifically, the sputum and the liquefied treatment liquid are loaded into the opening of the liquid storage chamber 201 , and then the opening of the liquid storage chamber 201 is sealed with the sealing member 240 , and at the same time, the enrichment membrane assembly 300 is installed at the other end of the cup body 100 .

[0091] S200: Install the liquid storage cover 200 onto the cup body 100 and assemble the negative pressure assembly 400 at the same time.

[0092] S300 : The filter port 120 is covered by the enrichment membrane assembly 300 , and then the liquid storage chamber 201 and the liquefaction chamber 110 are connected by the conducting structure, so that the liquid in the liquid storage chamber 201 flows into the liquefaction chamber 110 .

[0093] Specifically, by twisting the liquid storage cover 200 , the liquid storage cover 200 rotates and moves toward the filter port 120 , so that the cutting teeth 130 can cut through the seal 240 along the rotation direction of the liquid storage cover 200 , allowing the liquid in the liquid storage chamber 201 to flow into the liquefaction chamber 110 .

[0094] S400: The entire sputum enrichment device is shaken and mixed to fully liquefy the sputum. Specifically, the entire sputum enrichment device can be placed on a mixer and shaken and mixed to fully liquefy the sputum.

[0095] S500: The liquefied liquid in the liquefaction chamber 110 is sucked by the negative pressure assembly 400 so that all the liquid is enriched by the enrichment membrane assembly 300. Specifically, the piston rod 410 is pulled to drive the piston rubber head 420 to move downward.

[0096] S600: Remove the liquid storage cover 200 and then remove the enrichment membrane assembly 300 to proceed to the next treatment process.

[0097] Thus, compared with the prior art, the sputum enrichment device provided in this embodiment integrates the sputum liquefaction treatment and enrichment treatment processes, without the need for separate operations, simplifying the operating procedures and processes, and greatly reducing labor intensity. At the same time, the entire operation is completed in the liquid storage cover 200 and the cup body 100, without contact with the outside world, thereby avoiding the risk of leakage and pollution of the environment and cross infection, and the operation is more convenient, safer and more reliable.

[0098] It should be noted that all the above operations should be performed in a biosafety cabinet. After the enrichment is completed, the sputum enrichment device should be stored in a designated location and uniformly disposed of.

[0099] The above describes in detail the optional implementation methods of the embodiments of the present application in conjunction with the accompanying drawings. However, the embodiments of the present application are not limited to the specific details of the above implementation methods. Within the technical concept of the embodiments of the present application, various simple modifications can be made to the technical solutions of the embodiments of the present application, and these simple modifications all fall within the scope of protection of the embodiments of the present application.

[0100] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any appropriate manner unless there is any contradiction. In order to avoid unnecessary repetition, the embodiments of this application will no longer separately describe various possible combinations.

[0101] In addition, the various implementation methods of the embodiments of the present application can be arbitrarily combined, as long as they do not violate the ideas of the embodiments of the present application, they should also be regarded as the contents disclosed in the embodiments of the present application.

Claims

1. A sputum enrichment device, characterized in that: It comprises a cup body (100), a negative pressure assembly (400), a liquid storage cover (200) and an enrichment membrane assembly (300); One end of the cup body (100) is provided with a liquefaction chamber (110), and the other end is connected to the negative pressure component (400); the liquefaction chamber (110) has a filter port (120) communicating with the negative pressure component (400); The liquid storage cover (200) is detachably arranged at one end of the cup body (100) for sealing the liquefaction chamber (110), and the liquid storage cover (200) is provided with a liquid storage chamber (201) for sealing and storing liquid; The enrichment membrane assembly (300) is arranged on a side of the liquid storage cap (200) close to the filter port (120) to cover the filter port (120); A conducting structure is provided inside the liquefaction chamber (110), and the conducting structure is used to connect the liquid storage chamber (201) with the liquefaction chamber (110) when the enrichment membrane assembly (300) covers the filter port (120).

2. The sputum enrichment device according to claim 1, characterized in that: The liquid storage cavity (201) has an opening, the opening faces the filter port (120) and is provided with a sealing member (240); Wherein, the conductive structure is used to puncture or scratch the sealing member (240).

3. The sputum enrichment device according to claim 2, characterized in that: The liquid storage cover (200) is matched with the cup body (100) by a threaded pair, the conducting structure is a cutting tooth (130), and the cutting tooth (130) is arranged on the wall of the liquefaction chamber (110); Wherein, the enrichment membrane assembly (300) is used to seal the filter port (120) when the cutting teeth (130) puncture or scratch the sealing member (240).

4. The sputum enrichment device according to any one of claims 1 to 3, characterized in that: The liquid storage cap (200) comprises: The cover body (210) is matched with the thread pair of the cup body (100); a boss body (220) disposed on a side of the cover body (210) facing the cup body (100), wherein the liquid storage cavity (201) is disposed in the boss body (220), and an opening of the liquid storage cavity (201) is located at an end surface of the boss body (220); and A connecting body (230) is provided on a side of the cover body (210) facing the cup body (100) and is connected to the enrichment membrane assembly (300).

5. The sputum enrichment device according to claim 4, characterized in that: The inner peripheral wall of the cover body (210) is provided with an internal thread (211), and the outer peripheral wall of the cup body (100) is provided with an external thread (140) that matches the internal thread (211); The length of the internal thread (211) is greater than the movement stroke of the enrichment membrane assembly (300) covering the filter port (120).

6. The sputum enrichment device according to claim 1, characterized in that: The enrichment membrane assembly (300) is connected to the liquid storage cover (200) by heat welding; or, the enrichment membrane assembly (300) and the liquid storage cover (200) are an integral injection-molded structure; Wherein, a breakable connection portion (301) is formed between the enrichment membrane assembly (300) and the liquid storage cap (200).

7. The sputum enrichment device according to any one of claims 1 to 3 or 6, characterized in that: The enrichment membrane assembly (300) comprises: A membrane frame (310) is connected to the liquid storage cover (200), and a plurality of hollow hole areas (311) are provided on the membrane frame (310); and The enrichment filter membrane (330) is arranged on the membrane frame (310) and covers all the hollow hole areas (311).

8. The sputum enrichment device according to claim 1, characterized in that: A tapered section (111) for guiding flow is provided between the liquefaction chamber (110) and the filter port (120).

9. The sputum enrichment device according to claim 1, characterized in that: The other end of the cup body (100) is provided with a piston chamber (150) for accommodating the negative pressure assembly (400); The negative pressure assembly (400) comprises a piston rod (410) and a piston rubber head (420) arranged on the piston rod (410), and the piston rubber head (420) is interference-fitted with the piston cavity (150).

10. A sputum enrichment method, characterized in that: The sputum enrichment device according to any one of claims 1 to 9 is used, and the sputum enrichment method comprises: S100: Sputum and liquefaction treatment liquid are loaded into the liquid storage chamber (201) of the liquid storage cap (200) and the enrichment membrane assembly (300) is installed; S200: Installing the liquid storage cover (200) onto the cup body (100) and assembling the negative pressure assembly (400); S300: Covering the filter port (120) with the enrichment membrane assembly (300), and then conducting the liquid storage chamber (201) and the liquefaction chamber (110) through a conducting structure, so that the liquid in the liquid storage chamber (201) flows into the liquefaction chamber (110); S400: shaking and mixing the entire sputum enrichment device to fully liquefy the sputum; S500: sucking the liquefied liquid in the liquefaction chamber (110) through the negative pressure assembly (400), so that all the liquid passes through the enrichment membrane assembly (300) for enrichment; S600: Remove the liquid storage cover (200), then remove the enrichment membrane assembly (300), and proceed to the next treatment process.

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