Traditional Chinese medicine feed additive for preventing respiratory diseases of piglets and application of traditional Chinese medicine feed additive

Abstract

The invention relates to the field of feed additives, and aims to provide a traditional Chinese medicine feed additive for preventing respiratory diseases of piglets and application of the traditional Chinese medicine feed additive. The additive takes scutellaria baicalensis and honeysuckle as monarch drugs, pulsatilla chinensis as a ministerial drug, and bighead atractylodes rhizome, radix paeoniae alba, elecampane and pericarpium citri reticulatae as adjuvant drugs; the traditional Chinese medicine composition is specifically prepared from the following raw materials in parts by weight: 170 to 190 parts of radix scutellariae, 170 to 190 parts of flos lonicerae, 140 to 160 parts of radix pulsatillae, 140 to 160 parts of rhizoma atractylodis macrocephalae, 110 to 130 parts of radix paeoniae alba, 110 to 130 parts of radix aucklandiae and 90 to 110 parts of pericarpium citri reticulatae. According to the invention, a compatibility strategy of eliminating evil, strengthening body resistance and treating qi, blood and phlegm is creatively adopted, and a multi-target synergistic effect is adopted to realize the purpose of preventing the respiratory diseases of the piglets, so that the limitation of simply treating the respiratory diseases is broken through. The traditional Chinese medicine composition can improve the structure of respiratory flora of piglets, reduce the abundance of harmful bacteria and enhance the immunity of the organism, so that the occurrence probability of respiratory diseases is effectively reduced.

Description

Technical Field

[0001] The present invention relates to the field of feed additives, and in particular to a traditional Chinese medicine feed additive for preventing respiratory diseases in piglets and an application thereof. Background Art

[0002] Respiratory diseases are one of the most significant challenges in modern intensive pig farming. They not only lead to direct economic losses such as mortality and forced slaughter, but also severely impact production performance, resulting in indirect economic losses such as reduced daily weight gain, increased feed-to-meat ratio, prolonged fattening periods, and increased treatment costs. Piglets' immune systems are immature, and the stress of weaning and intensive housing can easily trigger respiratory diseases, leading to coughing, wheezing, growth stagnation, and even death. Furthermore, respiratory diseases are often co-infected with other pathogens, making prevention and control difficult and increasing medication costs.

[0003] Existing traditional Chinese medicine has many shortcomings in the treatment of piglet respiratory diseases. First, the formula is single, and it is mainly composed of heat-clearing drugs such as Scutellaria baicalensis and Forsythia suspensa, which only target local inflammation of the respiratory tract and do not take into account the physiological characteristics of the weak spleen and stomach of piglets. Second, when facing mixed infections such as viruses, bacteria, and mycoplasma, it is not targeted enough and lacks the ability to synergize multi-target antiviral, antibacterial, and anti-inflammatory treatments. Third, the medication focuses on eliminating pathogens while neglecting to strengthen the body. There is a lack of drugs that strengthen the spleen and replenish qi, which makes it difficult to enhance the immunity of piglets and leads to repeated attacks of the disease. Fourth, some prescriptions contain too high a proportion of bitter and cold drugs such as rhubarb and coptis chinensis, or use strong diaphoretic drugs such as ephedra, which can easily damage the delicate internal organs of piglets and cause adverse reactions such as diarrhea and dehydration. They are unsafe and not suitable for long-term or preventive use.

[0004] Therefore, the development of a safe and efficient Chinese medicine feed additive to prevent piglet respiratory diseases, regulate respiratory health, and reduce mortality rates is of great significance for the practice of green farming. Summary of the Invention

[0005] The technical problem to be solved by the present invention is to overcome the deficiencies of the prior art and provide a traditional Chinese medicine feed additive for preventing respiratory diseases in piglets and its application.

[0006] To solve the technical problem, the solution of the present invention is:

[0007] Provided is a traditional Chinese medicine feed additive for preventing respiratory diseases in piglets. The additive uses scutellaria baicalensis and honeysuckle as main medicines, pulsatilla scabra as auxiliary medicine, and atractylodes macrocephala, white peony root, costus root, and dried tangerine peel as adjuvant medicines. The additive is specifically composed of the following raw materials in parts by weight: 170-190 parts of scutellaria baicalensis, 170-190 parts of honeysuckle, 140-160 parts of pulsatilla scabra, 140-160 parts of atractylodes macrocephala, 110-130 parts of white peony root, 110-130 parts of costus root, and 90-110 parts of dried tangerine peel.

[0008] As a preferred embodiment of the present invention, the invention is specifically composed of the following raw materials in parts by weight: 180 parts of scutellaria baicalensis, 180 parts of honeysuckle, 150 parts of pulsatilla, 150 parts of atractylodes, 120 parts of white peony root, 120 parts of costus root, and 100 parts of dried tangerine peel.

[0009] As a preferred embodiment of the present invention, the dosage form is a powder with a particle size ranging from 80 to 120 meshes.

[0010] The present invention further provides a method for preparing the aforementioned Chinese medicinal feed additive, comprising weighing the raw materials according to the weight proportions, drying the raw materials, crushing the raw materials, passing the raw materials through an 80-120 mesh sieve, and uniformly mixing the raw materials to obtain the feed additive product.

[0011] The present invention also provides the use of the above-mentioned traditional Chinese medicine feed additive in preparing feed for preventing respiratory diseases in piglets.

[0012] The present invention also provides the use of the aforementioned traditional Chinese medicine feed additive in preparing feed for improving the microbial flora structure of the respiratory tract of piglets.

[0013] The present invention further provides a feed for preventing respiratory diseases in piglets. The feed contains the aforementioned Chinese medicinal feed additive, and the mass percentage of the Chinese medicinal feed additive in the feed is 0.5% to 1%.

[0014] The present invention further provides a feed for improving the microbial flora structure of the respiratory tract of piglets. The feed contains the aforementioned Chinese medicinal feed additive, and the mass percentage of the Chinese medicinal feed additive in the feed is 0.5% to 1%.

[0015] As a preferred embodiment of the present invention, in addition to the Chinese medicinal feed additive, it also includes a basic diet suitable for piglets; the components of the basic diet include corn, soybean meal and fish meal.

[0016] The present invention further provides a method for using the feed, comprising: taking appropriate amounts of feed and drinking water, stirring them to uniformly mix the Chinese medicinal feed additive with the basic diet, and obtaining feed for piglets.

[0017] Description of the invention principle:

[0018] The traditional Chinese medicine feed additive of the present invention realizes a treatment system of "clearing heat to dispel pathogenic factors, strengthening the spleen to consolidate the foundation, and regulating qi to treat symptoms" through a unique and reasonable compatibility, which not only quickly relieves respiratory symptoms but also fundamentally enhances the disease resistance of piglets. The formula includes: scutellaria baicalensis and honeysuckle as the main herbs, which clear lung heat, detoxify and resist inflammation, targeting the cause of respiratory heat and toxins; pulsatilla striata as the assistant herbs, which assists the main herbs in cooling blood and detoxifying, clearing heat and toxins from the blood; atractylodes macrocephala and white peony root, which strengthen the spleen and replenish qi, and enhance immunity; costus root and dried tangerine peel, which regulate qi and resolve phlegm, relieve cough and relieve asthma, and serve as adjuvant herbs. The combination of these herbs clears heat and detoxifies to dispel pathogenic factors, strengthens the spleen and regulates qi to strengthen the body, and treats qi, blood and phlegm simultaneously. The herbs have a mild nature, are suitable for the delicate internal organs of piglets, and achieve the effect of treating both the symptoms and the root cause.

[0019] The traditional Chinese medicine feed additive of the present invention can be mixed with a basic diet suitable for piglets to prepare feed, which can reduce the mortality rate of piglet respiratory diseases, improve the immunity of weaned piglets, and improve the structure of respiratory microbial flora.

[0020] Compared with the prior art, the present invention has the following beneficial effects:

[0021] 1. The applicant has found through long-term research that respiratory diseases in piglets are multifactorial, often caused by viral and bacterial infections combined with stress factors and low immunity. The present invention adopts an innovative compatibility strategy that simultaneously dispels pathogenic factors and strengthens the body's resistance, and treats qi, blood, and phlegm. The provided Chinese medicine composition is composed of scutellaria baicalensis, honeysuckle, pulsatilla, atractylodes macrocephala, white peony root, costus root, and dried tangerine peel; among them, scutellaria baicalensis, honeysuckle, and pulsatilla clear away heat and detoxify, costus root and dried tangerine peel relieve cough and asthma, and atractylodes macrocephala and white peony root strengthen the spleen and replenish qi. The multi-target synergistic effect is adopted to achieve the purpose of preventing respiratory diseases in piglets, breaking through the limitation of treating respiratory diseases alone.

[0022] 2. The Chinese medicine composition of the present invention can improve the structure of the respiratory flora of piglets, reduce the abundance of harmful bacteria, enhance the body's immunity, and thus effectively reduce the incidence of respiratory diseases. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 This is the Venn diagram of respiratory microbial OTUs used in the validation experiment.

[0024] Figure 2 To verify the impact of Beta diversity of respiratory microbial communities based on PCoA analysis in the experiment.

[0025] Figure 3 To verify the impact of Beta diversity of respiratory microbial communities based on Anosim analysis in the experiment. DETAILED DESCRIPTION

[0026] The present invention will be further described below with reference to specific embodiments. The experimental methods in the examples are conventional methods unless otherwise specified, and the test materials used in the following examples are commercially available unless otherwise specified.

[0027] Part I Technical Solutions and Specific Examples of the Invention

[0028] 1. The Chinese medicinal feed additive for preventing respiratory diseases in piglets provided by the present invention is composed of the following raw materials in parts by weight: 170-190 parts of scutellaria baicalensis, 170-190 parts of honeysuckle, 140-160 parts of pulsatillae, 140-160 parts of atractylodes macrocephala, 110-130 parts of white peony root, 110-130 parts of costus root, and 90-110 parts of dried tangerine peel. The most preferred compatibility ratio is: 180 parts of scutellaria baicalensis, 180 parts of honeysuckle, 150 parts of pulsatillae, 150 parts of atractylodes macrocephala, 120 parts of white peony root, 120 parts of costus root, and 100 parts of dried tangerine peel.

[0029] The preparation method of the traditional Chinese medicine feed additive comprises: weighing various raw materials according to the weight parts, drying them, crushing them, passing them through an 80-120 mesh sieve, and mixing them evenly to obtain the feed additive product, which is in the form of a powder.

[0030] The Chinese medicinal feed additive of the present invention can be used to prepare feed for preventing respiratory diseases in piglets and / or improving the microbial flora structure of the piglet's respiratory tract. Specifically, the Chinese medicinal feed additive is added to a basal diet suitable for piglets, with the weight percentage of the Chinese medicinal feed additive in the feed being 0.5% to 1%. In this way, a feed for preventing respiratory diseases in piglets and / or improving the microbial flora structure of the piglet's respiratory tract is prepared. The method for using the feed comprises taking appropriate amounts of feed and drinking water, stirring the Chinese medicinal feed additive and the basal diet until uniformly mixed, and obtaining a feed for piglets.

[0031] The basic diet suitable for piglets can be selected from commercial products, and its components generally include nutritional components such as corn, soybean meal and fish meal. The present invention does not impose any specific restrictions on the formula and content of the basic diet.

[0032] Example 1

[0033] Preparation of a traditional Chinese medicine feed additive: 180 parts of scutellaria baicalensis, 180 parts of honeysuckle, 150 parts of pulsatilla, 150 parts of atractylodes macrocephala, 120 parts of white peony root, 120 parts of costus root, and 100 parts of dried tangerine peel. The raw materials are weighed according to the weight parts, dried, crushed, passed through an 80-mesh sieve, and uniformly mixed to obtain a feed additive product.

[0034] Prepare feed: add the Chinese medicinal feed additive to the basic diet, and the mass percentage of the Chinese medicinal feed additive in the feed is 0.5%.

[0035] Preparation of feed: Take appropriate amount of feed and drinking water, stir to mix the Chinese medicinal feed additive and basic diet evenly, and obtain feed for piglets.

[0036] Example 2

[0037] Preparation of a traditional Chinese medicine feed additive: 170 parts of scutellaria baicalensis, 190 parts of honeysuckle, 160 parts of pulsatilla, 160 parts of atractylodes macrocephala, 130 parts of white peony root, 130 parts of costus root, and 90 parts of dried tangerine peel. The raw materials are weighed according to the weight parts, dried, crushed, sieved through a 120-mesh sieve, and uniformly mixed to obtain a feed additive product.

[0038] Prepare feed: add the Chinese medicinal feed additive to the basic diet, and the mass percentage of the Chinese medicinal feed additive in the feed is 0.75%.

[0039] Preparation of feed: Take appropriate amount of feed and drinking water, stir to mix the Chinese medicinal feed additive and basic diet evenly, and obtain feed for piglets.

[0040] Example 3

[0041] Preparation of a traditional Chinese medicine feed additive: 190 parts of scutellaria baicalensis, 170 parts of honeysuckle, 140 parts of pulsatilla, 140 parts of atractylodes macrocephala, 110 parts of white peony root, 110 parts of costus root, and 110 parts of dried tangerine peel. The raw materials are weighed according to the weight parts, dried, crushed, sieved through a 100-mesh sieve, and uniformly mixed to obtain a feed additive product.

[0042] Prepare feed: add the Chinese medicinal feed additive to the basic diet, and the mass percentage of the Chinese medicinal feed additive in the feed is 1%.

[0043] Preparation of feed: Take appropriate amount of feed and drinking water, stir to mix the Chinese medicinal feed additive and basic diet evenly, and obtain feed for piglets.

[0044] Part II Verification Test and Result Analysis

[0045] Verification experiment 1: Effects of Chinese herbal feed additives on growth performance, immunity and respiratory flora structure of weaned piglets

[0046] 1 Materials and Methods

[0047] 1.1 Experimental design and breeding management

[0048] In the feed used in the experimental group, the specific components and addition amounts of the Chinese medicinal feed additives were as described in Example 1.

[0049] Experimental location: Zhejiang Jingdao Agriculture and Animal Husbandry Technology Co., Ltd. (Hangzhou, Zhejiang Province).

[0050] Experimental animals: 106 14-day-old weaned piglets (Du × Chang × Da) were selected and randomly divided into 3 groups, with 3 litters in each group. The control group was fed a basal diet, the experimental group added a Chinese herbal feed additive to the basal diet (accounting for 0.5% of the total feed weight), and the Western medicine group added tilmicosin to the basal diet (20% tilmicosin premix was selected, accounting for 0.1% of the total feed weight). The experimental period was 15 days. The daily management of the experimental site and the immunization measures for weaned piglets were carried out in accordance with the standard production procedures of the pig farm. During the experiment, the temperature, ventilation, lighting and other conditions of each group were kept consistent, and food and water were available ad libitum. After the experiment, blood was collected from the anterior vena cava, and the pigs were slaughtered and oropharyngeal samples were collected for subsequent testing.

[0051] 1.2 Test methods

[0052] (1) Growth performance

[0053] After fasting for 12 hours, the experimental pigs were weighed on an empty stomach in the morning of the 1st and 15th day of the experiment, and the initial and final weights of the piglets in each group were recorded to calculate the ADG (average daily gain). The daily feed intake was recorded during the entire experimental period to calculate the ADFI (average daily feed intake). The feed-to-gain ratio (F / G) was calculated based on the ADFI and ADG.

[0054] (2) Determination of blue ear antibodies

[0055] The levels of blue ear antibodies in serum samples were detected using the corresponding ELISA kits, and the results were calculated and determined according to the following method:

[0056] The formula for calculating the S / P ratio of blue ear antibodies is: S / P = (sample OD value - negative serum control OD mean) / (positive serum control OD mean - negative serum control OD mean), S / P ≥ 0.4 is considered positive.

[0057] (3) Absolute quantitative PCR assay

[0058] The 16S rRNA gene of Haemophilus parasuis was cloned into the pMD-18T vector and diluted 10-fold. The Ct values ​​of the standard and the oropharyngeal sample to be tested were measured using a fluorescent quantitative PCR instrument. A standard curve was constructed with the logarithmic value of the standard copy number as the abscissa and the measured Ct value as the ordinate. When quantifying the sample to be tested, the Ct value of the sample was used to determine the copy number of the sample in the standard curve.

[0059] (4) Analysis of microbial composition of respiratory tract contents

[0060] Oropharyngeal samples were sent to Hangzhou Lianchuan Biotechnology Co., Ltd. for 16S rDNA sequencing. The specific analysis process included the following operations.

[0061] Genomic DNA extraction and sample detection: A commercially available extraction kit was used to extract total microbiome DNA, and Qubit was used to quantify the DNA.

[0062] PCR amplification: 16S rDNA variable regions (V3 + V4) were amplified. PCR products were purified using AMPure XT beads and quantified using Qubit.

[0063] Library pooling and sequencing: The purified PCR products were evaluated using an Agilent 2100 bioanalyzer and an Illumina library quantification kit. Qualified sequencing libraries (index sequences were not repeatable) were serially diluted, mixed in the appropriate proportions according to the required sequencing volume, and denatured into single-stranded DNA using NaOH for sequencing. 2×250bp paired-end sequencing was performed using a NovaSeq 6000 sequencer.

[0064] Sequencing data processing: Paired-end sequencing data were split according to barcode information, and adapters and barcode sequences were removed. Sequences were spliced ​​into long tags using FLASH. High-quality tag data was then filtered through rigorous filtering, and chimeras were filtered using Vsearch. DADA2 was used for noise reduction and deduplication, generating ASV signature sequences and ASV abundance tables. Alpha and beta diversity were analyzed using QIIME.

[0065] 1.3 Data Analysis

[0066] The experimental data were analyzed by one-way analysis of variance using SPSS26.0 software, and the results were expressed as "mean ± standard error". P < 0.05 indicated a significant difference, and P > 0.05 indicated an insignificant difference.

[0067] 2 Test results

[0068] 2.1 Effects of Chinese herbal feed additives on growth performance of weaned piglets

[0069] The effect of adding the Chinese herbal composition to the feed on the growth performance of weaned piglets is shown in Table 1. As shown in Table 1, compared with the control group, the test group significantly increased ADG (P<0.001) and significantly reduced F / G, indicating that the Chinese herbal feed additive of the present invention can promote the growth of weaned piglets.

[0070] Table 1 Effects of Chinese herbal feed additives on growth performance of weaned piglets

[0071]

[0072] Note: In the same data, different lowercase letters with superscripts indicate significant differences (P<0.05), while no superscript or the same lowercase letters with superscripts indicate no significant differences (P>0.05).

[0073] 2.2 Effects of Chinese herbal feed additives on immunity of weaned piglets

[0074] The effects of the traditional Chinese medicine feed additive on the levels of blue ear antibodies in the serum of weaned piglets are shown in Table 2. Compared with the control group, both the experimental and Western medicine groups significantly increased blue ear antibody levels (P < 0.05), significantly increasing the antibody positivity rate. There were no significant differences between the experimental and Western medicine groups. These results demonstrate that the traditional Chinese medicine feed additive of the present invention can enhance the immune function of weaned piglets.

[0075] Table 2 Effects of Chinese herbal feed additives on blue ear antibodies in weaned piglets

[0076]

[0077] 2.3 Effects of Chinese herbal feed additives on respiratory pathogens in weaned piglets

[0078] As shown in Table 3, compared with the control group, the experimental group and the Western medicine group significantly reduced the absolute content of Haemophilus parasuis in the oropharynx of weaned piglets (P < 0.05). There was no significant difference between the experimental group and the Western medicine group. The results show that the Chinese herbal feed additive of the present invention can reduce the absolute content of major respiratory pathogens.

[0079] Table 3 Effects of Chinese herbal feed additives on the absolute content of Haemophilus parasuis in the respiratory tract of weaned piglets

[0080]

[0081] 2.4 Effects of Chinese herbal feed additives on the respiratory microbial composition of weaned piglets

[0082] 2.4.1 OTU division and diversity analysis

[0083] like Figure 1 As shown in the figure, a total of 1232 different OTUs were identified in the 10 samples, of which 950 OTUs were found in the control group (C), 583 OTUs were found in the experimental group (T), and there were 301 common OTUs.

[0084] 2.4.2 Alpha Diversity Analysis

[0085] Alpha diversity analysis is shown in Table 4. Goods coverage reflects the coverage of low-abundance OTUs in the sample. Goods coverage was close to 1 in both sample groups, indicating that the sequencing results cover most respiratory bacteria. The ace and Chao1 indices comprehensively reflect community richness; larger values ​​indicate a greater number of species. Both indices were significantly reduced in the experimental group (P < 0.01), indicating that the traditional Chinese medicine feed additive of the present invention can reduce the diversity of respiratory tract flora.

[0086] Table 4 Effects of Chinese herbal feed additives on the α diversity of respiratory microbial flora in weaned piglets

[0087]

[0088] 2.4.3 Beta Diversity Analysis

[0089] like Figure 2 As shown in Figure 2, principal coordinate analysis (PCoA) showed that the distances within the two groups of respiratory microbial samples were close, the distances between the groups were far, and the samples were well clustered. Figure 3 As shown, R>0, indicating that the distance within the group is smaller than the distance between groups, the grouping is effective, and the statistics are significant (P<0.01).

[0090] In summary, it can be seen that by adding the traditional Chinese medicine feed additive of the present invention to the basic diet, the diversity of respiratory tract flora can be significantly reduced, the absolute content of Haemophilus parasuis can be reduced, the body's immunity can be enhanced, and the growth performance can be improved.

[0091] Verification experiment 2: Preventive effect of Chinese herbal feed additives on respiratory diseases in piglets

[0092] The Chinese medicine composition of the present invention has reasonable compatibility of the various drugs, fully exerts the effect of each drug, and the drugs work together to enhance the efficacy. Due to the large amount of experimental data in the present invention, the prescription was adjusted and tested many times. Here, only the preventive effects of multiple prescriptions on piglet respiratory diseases are listed and compared with the prescription of the present invention.

[0093] The prescription of comparative example 1: 180 parts of scutellaria baicalensis, 180 parts of honeysuckle, 150 parts of atractylodes macrocephala, 120 parts of white peony root, 120 parts of costus root, and 100 parts of dried tangerine peel.

[0094] The prescription of comparative example 2: 180 parts of scutellaria baicalensis, 180 parts of honeysuckle, 150 parts of pulsatilla, 120 parts of costus root, and 100 parts of dried tangerine peel.

[0095] The prescription of comparative example 3: 180 parts of scutellaria baicalensis, 180 parts of honeysuckle, 150 parts of pulsatilla, 150 parts of atractylodes macrocephala, and 120 parts of white peony root.

[0096] The prescription of Example 1 of the present invention includes 180 parts of Scutellaria baicalensis, 180 parts of Honeysuckle, 150 parts of Pulsatilla chinensis, 150 parts of Atractylodes macrocephala, 120 parts of White Peony Root, 120 parts of Costus root, and 100 parts of Tangerine Peel.

[0097] 1. Trial subjects and groups

[0098] A piglet-to-pig experiment was conducted at a farm with a history of bacterial pneumonia. Four groups, each consisting of 60 piglets, were housed individually in separate pens. Groups I, II, III, and IV were designated for the study. Each group was released between 15 and 20 days of age and again between 35 and 40 days of age. The piglets were fed a feed containing additives once daily for five consecutive days, allowing them to eat freely. Free access to water was provided throughout the study. The piglets were observed from the time of release until 75 days of age, and the incidence and mortality rates were recorded.

[0099] Group I: According to the formula of comparative example 1, 0.5% of the total weight of feed additives were added to the basal diet;

[0100] Group II: According to the formulation of comparative example 2, 0.5% of the total weight of feed additives were added to the basal diet;

[0101] Group III: According to the formulation of comparative example 3, 0.5% of the total weight of feed additives were added to the basal diet;

[0102] Group IV: According to the formulation of Example 1 of the present invention, 0.5% of the total weight of the feed additives were added to the basal diet.

[0103] 2. Mortality

[0104] During the trial, pigs that developed typical symptoms and died, had characteristic lesions detected during autopsy, and had pathogenic bacteria isolated from relevant tissues were considered infected and died. The percentage of infected pigs to the total number of pigs in each group was the mortality rate for that group.

[0105] 3. Test results

[0106] The preventive effects of each group of piglets during the experimental period are shown in Table 5.

[0107] Table 5 Preventive effect of each group on respiratory diseases

[0108]

[0109] As can be seen from the table, the mortality rate in Group IV was significantly lower than in Groups I, II, and III. These results demonstrate that the ideal preventive effect cannot be achieved when any of the individual herbs in the Chinese herbal composition of the present invention are missing. This demonstrates that the Chinese herbal composition of the present invention is formulated using the principles of TCM dialectical treatment, leveraging the synergistic effects of the herbs, and that no single ingredient in the formula can be omitted.

[0110] The above describes specific embodiments of the present invention. It should be understood that the present invention is not limited to the specific embodiments described above, and those skilled in the art may make various variations or modifications within the scope of the claims without affecting the essence of the present invention. Any equivalent implementation or modification that does not depart from the scope of the present invention should be included within the scope of the technical solution of the present invention.

Claims

1. A Chinese medicinal feed additive for preventing respiratory diseases in piglets, characterized in that: The invention adopts scutellaria baicalensis and honeysuckle as main drugs, pulsatilla scutellariae as assistant drugs, and atractylodes macrocephala, white peony root, costus root and dried tangerine peel as adjuvant drugs. The invention specifically comprises the following raw materials in parts by weight: 170-190 parts of scutellaria baicalensis, 170-190 parts of honeysuckle, 140-160 parts of pulsatilla scutellariae, 140-160 parts of atractylodes macrocephala, 110-130 parts of white peony root, 110-130 parts of costus root and 90-110 parts of dried tangerine peel.

2. The Chinese medicinal feed additive according to claim 1, characterized in that Specifically, the invention is composed of the following raw materials in parts by weight: 180 parts of scutellaria baicalensis, 180 parts of honeysuckle, 150 parts of pulsatilla, 150 parts of atractylodes macrocephala, 120 parts of white peony root, 120 parts of costus root, and 100 parts of dried tangerine peel.

3. The Chinese medicinal feed additive according to claim 1, characterized in that The dosage form is powder with a particle size range of 80 to 120 mesh.

4. The method for preparing the Chinese medicinal feed additive according to any one of claims 1 to 3, characterized in that: The raw materials are weighed according to the weight proportions, dried, crushed, passed through an 80-120 mesh sieve, and uniformly mixed to obtain the feed additive product.

5. Use of the traditional Chinese medicine feed additive according to any one of claims 1 to 3 in preparing feed for preventing respiratory diseases in piglets.

6. Use of the traditional Chinese medicine feed additive according to any one of claims 1 to 3 in preparing feed for improving the microbial flora structure of the respiratory tract of piglets.

7. A feed for preventing respiratory diseases in piglets, characterized in that: The feed contains the Chinese medicinal feed additive according to any one of claims 1 to 3, and the mass percentage of the Chinese medicinal feed additive in the feed is 0.5% to 1%.

8. A feed for improving the microbial flora structure of the respiratory tract of piglets, characterized in that: The feed contains the Chinese medicinal feed additive according to any one of claims 1 to 3, and the mass percentage of the Chinese medicinal feed additive in the feed is 0.5% to 1%.

9. The feed according to claim 7 or 8, characterized in that In addition to traditional Chinese medicine feed additives, the invention also comprises a basic diet suitable for piglets; the components of the basic diet include corn, soybean meal and fish meal.

10. The method for using the feed according to claim 7 or 8, characterized in that: include: Take appropriate amounts of feed and drinking water, stir them to evenly mix the Chinese medicinal feed additive with the basic diet, and obtain feed for piglets.

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