High-strength high-toughness silk fibroin-based material and preparation method and application thereof

By adding nanofibers to a silk fibroin precursor solution and subjecting it to chemical cross-linking and gradient ethanol treatment, a composite cross-linked network and a regular crystalline structure are formed, solving the problem of insufficient strength and toughness of silk fibroin-based materials in existing technologies. This enables the preparation and large-scale production of high-strength and high-toughness materials, which are suitable for biomedical materials.

CN120757812BActive Publication Date: 2025-11-11DONGHUA UNIV
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Patent Information

Application Number
CN202511256504.4
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-09-04
Publication Date
2025-11-11
Estimated Expiration
2045-09-04

AI Technical Summary

Technical Problem

Existing technologies make it difficult to prepare silk fibroin-based materials that combine high strength and high toughness. Furthermore, conventional preparation processes rely on high temperature and high pressure, resulting in high production costs and complex processes, which are not conducive to large-scale production.

Method used

By adding nanofiber dispersion to silk fibroin precursor solution, visible light is used to initiate chemical cross-linking to form a silk fibroin-nanofiber composite hydrogel with moderate cross-linking density. Gradient ethanol treatment and vacuum drying are then performed to form a composite cross-linking network and a regular β-sheet crystalline structure.

Benefits of technology

It achieves high strength and high toughness of silk fibroin-based materials, with simple process and suitable for large-scale production, and can be applied in the field of biomedical materials such as orthopedic implants.

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Abstract

This invention belongs to the field of biofunctional polymer materials technology, and relates to a high-strength, high-toughness silk fibroin-based material, its preparation method, and its applications. This material possesses a composite cross-linked network; the composite cross-linked network consists of a chemical cross-linked network formed between silk fibroin molecules and a physical cross-linked network formed by the entanglement of silk fibroin and nanofibers. The silk fibroin has a regular and uniform structure. β The material exhibits a folded crystalline structure with partially oriented nanofibers. It is prepared by adding a nanofiber dispersion to a silk fibroin precursor solution of specific composition and ratio, followed by uniform dispersion and then chemical cross-linking under visible light at 25–37°C to obtain a silk fibroin-nanofiber composite hydrogel. This hydrogel is then subjected to gradient ethanol treatment and vacuum drying. This material can be applied to biomedical materials such as biodegradable bone screws and plates. This invention achieves a balance between high strength and high toughness in silk fibroin-based materials.
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