Medicinal and edible traditional Chinese medicine composition for clearing damp and reducing fat, preparation, application and preparation method of medicinal and edible traditional Chinese medicine composition

Abstract

The invention relates to a medicinal and edible traditional Chinese medicine composition for clearing damp and reducing fat, a preparation, application and a preparation method of the medicinal and edible traditional Chinese medicine composition for clearing damp and reducing fat, and the medicinal and edible traditional Chinese medicine composition is prepared from the following raw materials: rhizoma polygonati, dandelion, agastache rugosus, radix polygonati officinalis, lophatherum gracile, lalang grass rhizome, poria cocos, coix seeds, curcumin, black pepper and L-arabinose. The production process is simple, the cost is low, the implementation is strong, and large-scale industrial development is easy; the traditional Chinese medicine composition is used for improving the damp-heat environment, inflammation state and fat metabolism disorder of the body, the fat reducing effect is remarkable, the raw materials used in the formula are all medicine and food homologous traditional Chinese medicines, food additives and new resource food, safety is high, and patient compliance is good.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of traditional Chinese medicine, in particular to a dampness-removing and fat-reducing medicinal and edible traditional Chinese medicine composition, preparation, use and preparation method thereof. BACKGROUND

[0002] In today's society, the number of overweight and obese people is increasing, and the trend is rising. Obesity is a chronic metabolic disease, mainly characterized by excessive accumulation of fat in the body and overweight, and the factors causing obesity are diverse, such as genetic factors, environmental factors, endocrine regulation abnormalities, inflammation, intestinal flora, etc. Obesity has become the largest chronic disease in the world.

[0003] Modern traditional Chinese medicine believes that obesity is caused by chronic inflammatory reaction of immune system mucosal barrier or lipid metabolism disorder in the body due to latent wet factors in the body, and the wet factors are widely sourced, mainly generated by the interaction of modern diet, exercise, lifestyle and work methods. The latent wet factors in the body cells, tissues, organs and body fluids cause changes in the body's metabolic system, affect the normal physiological functions of cells, tissues, organs and body fluids, and cause the accumulation of harmful metabolites and chronic inflammatory reactions. If the dampness is blocked for a long time, it will become heat, and the body will be in a damp-heat state, the ecological environment in the body will deteriorate, the mucosal flora will undergo massive apoptosis, and chronic inflammatory reactions and lipid metabolism disorders will occur. Therefore, improving the body's damp-heat environment, inflammation and lipid metabolism disorder is the fundamental measure to effectively reduce fat and weight.

[0004] The medicinal and edible fat-reducing products on the market have not mentioned improving the body's damp-heat environment, inflammation and lipid metabolism disorder, and the effect of fat and weight loss is very small and easy to rebound. At the same time, because the generation of wet factors involves all aspects of people's daily life, almost covering the whole life cycle, it puts forward higher requirements for fat-reducing products, not only meeting the needs of people's daily conditioning, but also achieving the purpose of preventing the disease from changing.

[0005] In summary, it is of great significance to develop a safe (medicinal and edible) and effective (improving the body's damp-heat environment, inflammation and lipid metabolism disorder) formula. SUMMARY

[0006] Therefore, the present application aims to provide a dampness-removing and fat-reducing medicinal and edible traditional Chinese medicine composition, preparation, use and preparation method thereof, so as to improve the body's damp-heat environment, inflammation and lipid metabolism disorder by selecting appropriate medicinal material raw materials and ratio, and achieve the purpose of safe and effective fat reduction.

[0007] The purpose of the present application is achieved by the following technical solutions:

[0008] A kind of medicine food homologous traditional Chinese medicine composition for reducing weight, which contains a therapeutically effective amount of Huangjing, Pugongying, Huoxiang, curcumin, black pepper and L-arabinose.

[0009] In some embodiments, the traditional Chinese medicine composition further contains a therapeutically effective amount of Yuzhu, Danzhuye, Baomaren, Fuling and Yiyiren.

[0010] In some embodiments, the traditional Chinese medicine composition contains Huangjing 9-15 parts, Pugongying 10-15 parts, Huoxiang 3-10 parts, curcumin 500 mg, black pepper 0.6-1.5 parts and L-arabinose 500 mg.

[0011] In some embodiments, the traditional Chinese medicine composition further contains Yuzhu 6-12 parts, Danzhuye 6-10 parts, Baomaren 9-30 parts, Fuling 10-15 parts and Yiyiren 9-30 parts.

[0012] In some embodiments, the traditional Chinese medicine composition contains Huangjing 12 parts, Pugongying 12 parts, Huoxiang 6 parts, curcumin 500 mg, black pepper 1.2 parts and L-arabinose 500 mg.

[0013] In some embodiments, the traditional Chinese medicine composition further contains Yuzhu 9 parts, Danzhuye 9 parts, Baomaren 15 parts, Fuling 12 parts and Yiyiren 15 parts.

[0014] In some embodiments, the traditional Chinese medicine preparation is any one of decoction, tablet, pill, capsule, powder, paste, granule or oral liquid.

[0015] In another aspect, the present application also provides a traditional Chinese medicine composition and use of the preparation thereof in reducing weight.

[0016] In another aspect, the present application also provides a preparation method of traditional Chinese medicine preparation, which comprises the following steps:

[0017] Weigh the traditional Chinese medicine components (except curcumin, black pepper and L-arabinose) in the amounts as described above, add 8 times the amount of water, decoct for 1.5 hours, filter; add 6 times the amount of water to the residue, decoct for 1 hour, filter, mix the two filtrates; grind black pepper, and add curcumin and L-arabinose to the mixed filtrate, stir thoroughly, and then obtain the decoction; or further concentrate, dry and crush to obtain the powder; or add appropriate amount of dextrin and flavoring agent, granulate, package, and then obtain the granules; or fill into capsule shells to obtain the capsules, etc.

[0018] The wet-reducing and fat-reducing medicinal and edible Chinese medicine composition, preparation, use and preparation method provided by the present application have simple production process, low cost, strong implementation and are easy to be developed in large scale; the Chinese medicine composition can effectively improve the damp-heat environment, inflammation state and fat metabolism disorder of the body, has remarkable fat-reducing effect, and the raw materials used in the formula are all medicinal and edible Chinese medicine, food additive and new resource food, which are safe and have good patient compliance.

[0019] In addition, the medicinal and edible Chinese medicine in the formula is all developed around clearing heat and removing dampness, the food additive curcumin is matched with the new resource food L-arabinose in the formula, and the two have the effects of anti-inflammation and anti-oxidation, and the new resource food L-arabinose has the effects of inhibiting the absorption and metabolism of sucrose and fat generation, so that the damp-heat environment, fat metabolism disorder and inflammation of the body are improved, the pathogenic factors causing fat accumulation are fundamentally removed, and the purpose of fat reduction is achieved. DETAILED DESCRIPTION

[0020] In order to enable those skilled in the art to better understand the technical solutions of the present application, the specific technical solutions of the present application will be described clearly and completely in combination with embodiments, so as to help those skilled in the art to further understand the present application. Obviously, the embodiments described in the present application are only a part of the embodiments of the present application, not all the embodiments. It should be pointed out that, for those skilled in the art, the embodiments in the present application and the features in the embodiments can be combined with each other without departing from the concept of the present application and without being in conflict with each other. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor should belong to the disclosure and protection scope of the present application.

[0021] In order to improve the damp-heat environment, inflammation state and fat metabolism disorder of the human body and achieve the purpose of safe and effective fat reduction, the present application provides a wet-reducing and fat-reducing medicinal and edible Chinese medicine composition, and the specific implementation manner includes the following: Specific embodiment 1

[0023] 1.1 In an effective implementation manner, the formula of the wet-reducing and fat-reducing medicinal and edible Chinese medicine composition and the preparation process of the capsule thereof include: weighing 9g of rhizoma polygonati, 10g of herba euporbiae, 3g of agastache rugosa, 500mg of curcumin (to be taken separately), 0.6g of black pepper (to be ground into powder), 500mg of L-arabinose (to be taken separately), adding 8 times the amount of water, decocting for 1.5 hours, and filtering; adding 6 times the amount of water to the filter residue, decocting for 1 hour, filtering, mixing the two filtrates, adding curcumin, black pepper powder and L-arabinose into the mixed filtrate, stirring thoroughly, concentrating, drying, and loading into a capsule shell to obtain a capsule that meets the daily dosage of a normal adult.

[0024] 1.2 In an effective implementation, the composition and capsule preparation process of the damp-reducing and fat-reducing herbal medicine composition includes: weighing turmeric 12g, dandelion 12g, agastache 6g, curcumin 500mg (to be taken separately), black pepper 1.2g (to be ground separately), L-arabinose 500mg (to be taken separately), adding 8 times the amount of water, decocting for 1.5 hours, filtering; adding 6 times the amount of water to the residue, decocting for 1 hour, filtering, mixing the two filtrates, adding curcumin, black pepper powder, and L-arabinose into the mixed filtrate, stirring thoroughly, concentrating, drying, and filling into capsule shells to obtain the capsule that meets the daily dosage of a normal adult.

[0025] 1.3 In an effective implementation, the composition and capsule preparation process of the damp-reducing and fat-reducing herbal medicine composition includes: weighing turmeric 12g, dandelion 12g, agastache 6g, curcumin 500mg (to be taken separately), black pepper 1.2g (to be ground separately), L-arabinose 500mg (to be taken separately), adding 8 times the amount of water, decocting for 1.5 hours, filtering; adding 6 times the amount of water to the residue, decocting for 1 hour, filtering, mixing the two filtrates, adding curcumin, black pepper powder, and L-arabinose into the mixed filtrate, stirring thoroughly, concentrating, drying, and filling into capsule shells to obtain the capsule that meets the daily dosage of a normal adult.

[0026] The damp-reducing and fat-reducing herbal medicine composition in the above examples 1.1 to 1.3 contains a therapeutically effective amount of traditional Chinese medicine components and can be used to improve the body's damp-heat environment, inflammatory state, and fat metabolism disorder to reduce weight and fat. When used, the patient can take it orally, twice a day.

[0027] Specific embodiment 2, on the basis of the formula in embodiment 1, add: polygonatum, lophatheri, imperata, poria cocos, and coix seed, and make granules.

[0028] 2.1 In an effective implementation, the composition and granule preparation process of the damp-reducing and fat-reducing herbal medicine composition includes: weighing turmeric 12g, dandelion 12g, agastache 6g, curcumin 500mg (to be taken separately), black pepper 1.2g (to be ground separately), L-arabinose 500mg (to be taken separately), adding 8 times the amount of water, decocting for 1.5 hours, filtering; adding 6 times the amount of water to the residue, decocting for 1 hour, filtering, mixing the two filtrates, adding curcumin, black pepper powder, and L-arabinose into the mixed filtrate, stirring thoroughly, concentrating, drying, and filling into capsule shells to obtain the capsule that meets the daily dosage of a normal adult.

[0029] 2.2 In an effective embodiment, the preparation process of the composition of the damp-reducing and fat-reducing herbal medicine and granules includes: weighing: 12g of Rhizoma Polygonati, 12g of Herba Taraxaci, 6g of Agastache rugosa, 9g of Polygonatum odoratum, 9g of Folium Phyllostachy, 15g of Imperata cylindra, 12g of Poria cocos, 15g of Coix seed, 500mg of curcumin (to be taken separately), 1.2g of black pepper (to be ground separately), 500mg of L-arabinose (to be taken separately), adding 8 times the amount of water, decocting for 1.5 hours, filtering; adding 6 times the amount of water to the residue, decocting for 1 hour, filtering, mixing the two filtrates, adding curcumin, black pepper powder, and L-arabinose into the mixed filtrate, stirring thoroughly, concentrating, drying, adding appropriate amount of dextrin and flavoring agent, granulating according to the conventional process in the field, and packaging to obtain granules in accordance with the normal adult daily dosage.

[0030] 2.3 In an effective embodiment, the preparation process of the composition of the damp-reducing and fat-reducing herbal medicine and granules includes: weighing: 15g of Rhizoma Polygonati, 15g of Herba Taraxaci, 10g of Agastache rugosa, 12g of Polygonatum odoratum, 10g of Folium Phyllostachy, 30g of Imperata cylindra, 15g of Poria cocos, 30g of Coix seed, 500mg of curcumin (to be taken separately), 1.5g of black pepper (to be ground separately), 500mg of L-arabinose (to be taken separately), adding 8 times the amount of water, decocting for 1.5 hours, filtering; adding 6 times the amount of water to the residue, decocting for 1 hour, filtering, mixing the two filtrates, adding curcumin, black pepper powder, and L-arabinose into the mixed filtrate, stirring thoroughly, concentrating, drying, adding appropriate amount of dextrin and flavoring agent, granulating according to the conventional process in the field, and packaging to obtain granules in accordance with the normal adult daily dosage.

[0031] The damp-reducing and fat-reducing herbal medicine composition in the above examples 2.1 to 2.3 contains a therapeutically effective amount of traditional Chinese medicine composition, which can be further used to improve the body's damp environment, inflammatory state, and fat metabolism disorder to reduce fat and weight. When used, the patient can take it by infusion, taking it twice a day in the morning and evening.

[0032] Specific embodiment 3, on the basis of the formula in embodiment 1, add: Polygonatum odoratum, Folium Phyllostachy, Imperata cylindra, Poria cocos, and Coix seed, and make into a decoction.

[0033] 3.1 In an effective embodiment, the preparation process of the composition of the damp-reducing and fat-reducing herbal medicine and granules includes: weighing: 15g of Rhizoma Polygonati, 15g of Herba Taraxaci, 10g of Agastache rugosa, 12g of Polygonatum odoratum, 10g of Folium Phyllostachy, 30g of Imperata cylindra, 15g of Poria cocos, 30g of Coix seed, 500mg of curcumin (to be taken separately), 1.5g of black pepper (to be ground separately), 500mg of L-arabinose (to be taken separately), adding 8 times the amount of water, decocting for 1.5 hours, filtering; adding 6 times the amount of water to the residue, decocting for 1 hour, filtering, mixing the two filtrates, adding curcumin, black pepper powder, and L-arabinose into the mixed filtrate, stirring thoroughly, concentrating, drying, adding appropriate amount of dextrin and flavoring agent, granulating according to the conventional process in the field, and packaging to obtain granules in accordance with the normal adult daily dosage.

[0034] 3.2 In an effective implementation, the composition and its preparation process of the damp-reducing and fat-reducing medicinal and edible Chinese medicine composition include: taking 12g of rhizoma polygonati, 12g of herba taraxaci, 6g of agastache rugosa, 9g of polygonatum, 9g of lophatheri, 15g of imperata cylindrica, 12g of poria cocos, 15g of coix seed, 500mg of curcumin (to be taken separately), 1.2g of black pepper (to be ground into powder), 500mg of L-arabinose (to be taken separately), and adding 8 times the amount of water, decocting for 1.5 hours, and filtering; the filter residue is added with 6 times the amount of water, decocted for 1 hour, filtered, and the two filtrates are mixed, curcumin, black pepper powder, and L-arabinose are added into the mixed filtrate, stirred thoroughly, and a decoction is prepared according to conventional Chinese medicine preparation technology.

[0035] 3.3 In an effective implementation, the composition and its preparation process of the damp-reducing and fat-reducing medicinal and edible Chinese medicine composition include: taking 15g of rhizoma polygonati, 15g of herba taraxaci, 10g of agastache rugosa, 12g of polygonatum, 10g of lophatheri, 30g of imperata cylindrica, 15g of poria cocos, 30g of coix seed, 500mg of curcumin (to be taken separately), 1.5g of black pepper (to be ground into powder), 500mg of L-arabinose (to be taken separately), and adding 8 times the amount of water, decocting for 1.5 hours, and filtering; the filter residue is added with 6 times the amount of water, decocted for 1 hour, filtered, and the two filtrates are mixed, curcumin, black pepper powder, and L-arabinose are added into the mixed filtrate, stirred thoroughly, and a decoction is prepared according to conventional Chinese medicine preparation technology.

[0036] The damp-reducing and fat-reducing medicinal and edible Chinese medicine composition in the above examples 3.1 to 3.3 can be further used for improving the body's damp-heat environment, inflammatory state, and fat metabolism disorder to reduce fat and weight. When used, the patient can take orally, taking twice a day in the morning and evening.

[0037] The components of the above examples are all medicinal and edible Chinese medicine, food additives, and new resource food, which are safe and effective, and can meet the daily conditioning needs of modern people, prevent disease before it occurs, and prevent the spread of disease when it occurs.

[0038] In addition, one or more than one mixture of diluents, lubricants, binders, disintegrating agents, sweeteners, stabilizers, and preservatives can be added to the Chinese medicine formula preparation.

[0039] The damp-reducing and fat-reducing Chinese medicine composition can be prepared into any conventional oral preparation by using existing Chinese medicine preparation technology, for example, the above components can be obtained by water decoction method to obtain a decoction, and the damp-reducing and fat-reducing Chinese medicine formula can be prepared into any one of tablets, pills, capsules, powders, pastes, granules, and oral liquids by other existing Chinese medicine preparation technology.

[0040] The effects of the raw materials used in the present application are as follows:

[0041] Polygonatum sibiricum: Sweet, neutral. Enters the spleen, lung, and kidney meridians. Replenishes qi and nourishes yin, strengthens the spleen, moistens the lungs, and benefits the kidneys. Used for spleen and stomach qi deficiency, fatigue, stomach yin deficiency, dry mouth and poor appetite, lung deficiency and dry cough, hemoptysis caused by exertion, deficiency of essence and blood, soreness of the waist and knees, premature graying of hair, and internal heat and thirst.

[0042] Dandelion: Bitter, sweet, and cold. Enters the Liver and Stomach meridians. Clears heat and detoxifies, reduces swelling and resolves stagnation, and promotes diuresis and relieving stranguria. Used for carbuncle swelling, breast abscess, scrofula, conjunctivitis, sore throat, lung abscess, intestinal abscess, damp-heat jaundice, and painful stranguria caused by heat.

[0043] Patchouli: Pungent, slightly warm. It enters the spleen, stomach, and lung meridians. Its aromatic properties clear turbidity, soothe the stomach and stop vomiting, and relieve heatstroke. It is used for dampness and turbidity blocking the middle part of the body, abdominal distension and vomiting, symptoms of dampness and summer heat, the initial onset of damp-heat syndrome, fever and fatigue, chest tightness and discomfort, cold-dampness-induced summer heat, abdominal pain, vomiting and diarrhea, and sinusitis and headache.

[0044] Polygonatum odoratum: Sweet, slightly cold. Enters the Lung and Stomach meridians. Nourishes yin and moistens dryness, promotes fluid production and quenches thirst. Used for lung and stomach yin damage, dry-heat cough, dry throat and thirst, and internal heat and thirst.

[0045] Light bamboo leaves: sweet, light, cold. Entrance to the heart, stomach, small intestine meridians. Clears away heat and fire, relieves restlessness and thirst, and promotes urination and relieves stranguria. Used for heat

[0046] The patient suffers from thirst, short, red and painful urination, and ulcers in the mouth and tongue.

[0047] Imperata Rhizome: Sweet, cold. Enters the Lung, Stomach, and Bladder meridians. Cools blood and stops bleeding, clears heat and promotes urination. Used for hematemesis, epistaxis, hematuria, fever-induced thirst, damp-heat jaundice, edema, oliguria, and painful stranguria due to heat.

[0048] Poria: Sweet, mild, and neutral. It enters the Heart, Lung, Spleen, and Kidney meridians. It promotes diuresis and eliminates dampness, strengthens the spleen, and calms the mind. It is used for edema, oliguria, phlegm and fluid retention, dizziness and palpitations, spleen deficiency, poor appetite, loose stools and diarrhea, restlessness, palpitations, and insomnia.

[0049] Coix seed: Sweet, light, and cooling. It enters the spleen, stomach, and lung meridians. It promotes diuresis and eliminates dampness, strengthens the spleen and stops diarrhea, eliminates numbness, drains pus, and detoxifies and resolves lumps. It is used for edema, beriberi, dysuria, spleen deficiency diarrhea, dampness-induced stiffness and cramps, lung abscesses, intestinal abscesses, warts, and cancer.

[0050] Curcumin: has anti-inflammatory, antioxidant, lipid-lowering, anti-tumor, and choleretic effects.

[0051] Black pepper: Pungent and hot. Enters the stomach and large intestine meridians. Warms the middle and dispels cold, promotes the flow of qi, and eliminates phlegm. Used for stomach cold, vomiting, abdominal pain, diarrhea, loss of appetite, and epilepsy with excessive phlegm.

[0052] L-arabinose: inhibits the activity of sucrase in the human intestine, thereby inhibiting the absorption and metabolism of sucrose; controls blood pressure, inhibits fat production, promotes the proliferation of bifidobacteria, prevents constipation, relieves alcohol and protects the liver.

[0053] The beneficial effects of the present application are illustrated below in combination with clinical experimental data:

[0054] 1. General information

[0055] From May 2023 to November 2023, the inventor collected 105 obese outpatients.

[0056] Inclusion criteria: aged 18-75 years, diagnosed with metabolic obesity (BMI ≥ 28 kg / m² and body fat rate ≥ 25% for males and ≥ 30% for females) or central obesity (waist-to-hip ratio ≥ 0.90 for males and ≥ 0.85 for females), TCM syndrome differentiation belongs to damp-heat obstructing spleen syndrome (main symptoms: obesity, fatigue, sleepiness, sticky stool; secondary symptoms: abdominal distension, dry mouth, bitter taste, yellow and thick tongue coating), need to meet the abnormality of inflammation / metabolic indicators (serum CRP ≥ 5 mg / L or fasting insulin ≥ 15 μIU / mL), and complete follow-up.

[0057] Exclusion criteria: combined with severe heart failure (NYHA classification III-IV), liver and kidney dysfunction (ALT / AST > 3 times the upper limit or eGFR < 30 mL / min), tumor or immunodeficiency disease, pregnant / lactating women, allergic to any component in the formula (such as polygonatum, dandelion, curcumin), use of GLP-1 receptor agonists, orlistat and other weight loss drugs within the past month, other conditions deemed inappropriate by the researcher (such as mental disorders, anorexia nervosa).

[0058] Withdrawal criteria: occurrence of serious adverse events (such as allergic reactions, liver enzyme elevation > 5 times the upper limit), active withdrawal or loss of follow-up by the subject (3 consecutive times without receiving follow-up), termination of the trial by the researcher due to rapid deterioration of metabolic indicators (fasting blood glucose > 13.9 mmol / L or blood pressure > 180 / 110 mmHg), etc.

[0059] 2. Test method

[0060] Orally take the preparation prepared according to specific embodiments 1-3 of the present application, one course of treatment is 10 days, take 2-3 courses.

[0061] 3. Efficacy criteria and treatment results

[0062] 3.1 Efficacy criteria

[0063] Marked effect: significant weight loss, significant decrease in BMI index, and significant decrease in inflammatory factor level. Effective: weight loss, decrease in BMI index, and decrease in inflammatory factor level. Ineffective: no change in weight, BMI index, and inflammatory factor level.

[0064] 3.2 The treatment statistical results are shown in Table 1.

[0065] Table 1. Treatment results

[0066] Therefore, the prepared formula can effectively eliminate dampness and reduce fat.

[0067] 4. Typical cases:

[0068] Case 1

[0069] Wang, female, 35 years old. The main complaint is that the body weight continues to increase, the waist and abdominal fat accumulation is obvious, the daily food intake is normal but the limbs are easy to appear edema, the stool is sticky and unsmooth. Physical examination shows that the tongue is pale red, the thin yellow and slightly greasy fur, and the pulse is soft and slow. The diagnosis is metabolic retardation type fat accumulation caused by mild damp-heat accumulation. After taking the preparation formula of Example 1.1 of the present application for 14 days, the patient's body weight significantly decreases, the waist circumference is reduced, the body fat rate decreases, and the edema symptoms are obviously relieved.

[0070] Case 2

[0071] Zhang, male, 42 years old. The main complaint is long-term obesity accompanied by body fatigue and weakness, obvious abdominal distension after eating, and dry mouth and bitter symptoms. The conventional weight loss method has no effect. Physical examination shows that the tongue is large with obvious tooth marks at the edge, the thick yellow and greasy fur, and the pulse is slippery and rapid. The diagnosis is fat retention caused by damp-heat stagnation in the middle jiao and disorder of qi movement. After taking the preparation formula of Example 1.2 of the present application for 14 days, the body weight and BMI index significantly decrease, the abdominal distension and bitter symptoms basically disappear, and the physical state is improved.

[0072] It can be seen that the composition of the present application can relieve the symptoms related to damp-heat type obesity by eliminating dampness and resolving turbidity, and adjusting the metabolic mode. Huangjing and Pugongying are the monarch drugs. Huangjing supplements qi and nourishes yin, regulates sugar and lipid metabolism, and enhances insulin sensitivity to reduce body fatigue. Pugongying clears heat and resolves toxicity, and inhibits inflammation reaction of adipose tissue. Huoxiang promotes gastrointestinal peristalsis and improves abdominal distension. The core is the synergistic effect of curcumin (anti-inflammatory and liver protection), piperine (promoting absorption of curcumin), and L-arabinose (inhibiting intestinal sucrase): curcumin inhibits NF-κB pathway to reduce the secretion of inflammation factors in adipose tissue and reduce lipid deposition; piperine enhances the bioavailability of curcumin by 3-5 times and enhances its ability to regulate PPAR-γ pathway; L-arabinose blocks sugar absorption and reduces liver fat synthesis. The whole prescription can relieve abdominal distension and bitter taste, and improve physical strength by inhibiting lipid neogenesis, promoting energy consumption (about increasing basal metabolic rate by 8%-12%), and improving intestinal flora (increasing butyrate-producing bacteria abundance).

[0073] Case 3

[0074] Li, female, 48 years old. Complaints of severe obesity (BMI 31.4), feeling of heavy limbs, excessive oil secretion of the skin, and alternating constipation and diarrhea. Physical examination shows red and bright tongue, yellow and thick and greasy fur, and slippery and forceful pulse. Diagnosis of severe metabolic disorder caused by damp-heat accumulation and inflammation. After 14 days of treatment with the formulation of Example 1.3 of the present application, the body weight is significantly reduced, the inflammation index is improved, and the ultrasound examination shows that the degree of fatty liver is reduced.

[0075] Case Four

[0076] Patient Li, male, 52 years old, complains of long-term abdominal adipose tissue accumulation, continuous weight gain despite dietary control, and fatigue. Physical examination shows a large tongue, yellow and thick and greasy fur, and slippery pulse. Diagnosis of fatty metabolism disorder caused by damp-heat accumulation and spleen deficiency. Treatment with granules prepared according to the prescription of Example 2.1 of the present application, taken in the morning and evening. After 14 days of treatment, the body weight is reduced by 3.2 kg, the BMI is reduced from 28.1 to 26.9, the waist circumference is reduced by 5 cm, and the fatigue is significantly improved. The tongue fur is thin and white.

[0077] Case Five

[0078] Fan, female, 38 years old. Complaints of large belly and adipose tissue accumulation, and weight gain despite not eating much. Physical examination shows a large tongue, yellow and thick and greasy fur, and slippery pulse. Diagnosis: damp-heat stagnating the spleen leading to adipose tissue accumulation. Treatment: taking the formulation described in Example 2.2 of the present application for 14 days, the body weight is significantly reduced, and the BMI index is significantly reduced.

[0079] 2.2 Formula enhances diuresis and dampness, and invigorates the spleen and soothes the liver, and is specifically used for damp-heat stagnating the spleen type of adipose tissue accumulation. The addition of Polygonatum, Lophatherum gracile, Imperata cylindrica, Poria cocos, and Coix seed forms a "dampness-removing combination": Poria cocos and Coix seed activate the AMPK pathway to promote fatty acid oxidation, inhibit fatty acid synthase expression, and reduce visceral fat deposition; Imperata cylindrica diuresis and reduces jaundice, and promotes the excretion of uric acid and endogenous toxins (reduces serum triglycerides by 15-20%); Lophatherum gracile synergistically reduces lipids and regulates bile acid metabolism to improve greasy fur. Dextrin in granule form delays absorption and maintains drug concentration. Curcumin-black pepper system inhibits adipose tissue macrophage infiltration and reduces chronic inflammation (TNF-alpha decreases by about 30%); L-arabinose reduces dietary sugar energy supply, forcing the body to mobilize fat reserves. The whole formula significantly improves water and electrolyte metabolism disorder (yellow and thick and greasy fur disappears), reduces abdominal adipose tissue accumulation (reduces visceral fat area by about 10%), and naturally reduces body weight

[0080] Case Six

[0081] Patient Wang, female, 45 years old, complained of severe central obesity (BMI 32.4), abdominal circumference exceeding the standard with sticky and bitter mouth, and a long history of high-fat diet. Physical examination showed red and bright tongue, yellow and thick and sticky fur like accumulated powder, and slippery and rapid pulse. Diagnosis: stubborn fatty acid metabolism disorder caused by damp-heat and blood stasis, and difficulty in Qi transformation of Sanjiao. The patient was given the prescription granules of specific embodiment 2.3 twice a day. After 14 days of treatment, the patient's weight decreased by 5.8 kg, BMI decreased to 30.1, abdominal circumference decreased by 8 cm, and laboratory tests showed that the inflammation index (CRP) decreased by 42%. The thin white fur was revealed after the tongue fur was peeled off.

[0082] Case Seven

[0083] Patient Chen, male, 36 years old. Complaints: accumulation of fat in the waist and abdomen, increased appetite with dry and bitter mouth, and mild blood lipid abnormalities. Physical examination: tongue is slightly red, thin yellow and slightly greasy fur, and slippery and rapid pulse. Diagnosis: metabolic disorder caused by damp-heat accumulation in the stomach and intestines. Treatment: after taking the formula decoction of specific embodiment 3.1 of the present application for 30 days, the patient's weight decreased by 4.2 kg, BMI decreased from 26.8 to 25.1, waist circumference decreased by 6 cm, and blood lipid index improved.

[0084] Case Eight

[0085] Zhang, male, 53 years old. Complaints: beer belly, overweight, and moderate fatty liver. Physical examination: tongue is fat, tooth mark tongue, yellow and greasy fur, and slippery and rapid pulse. Diagnosis: fatty liver caused by damp-heat stagnation in liver meridians. Treatment: after taking the formula preparation of specific embodiment 3.2 of the present application for 30 days, the patient's weight decreased significantly, BMI index decreased significantly, and physical examination showed mild fatty liver.

[0086] For damp-heat stagnation in liver type fatty liver, the decoction form has the advantages of soothing liver and promoting bile secretion, and anti-fibrosis. The core mechanism is: curcumin activates Nrf2 pathway to improve liver antioxidant capacity, removes fatty oxidation products (MDA decreases by 40%), inhibits activation of hepatic stellate cells, and reduces fatty degeneration; dandelion contains chlorogenic acid to improve bile stasis and promote the decomposition of cholesterol into bile acid; triterpenes in Poria cocos inhibit TGF-β signaling pathway and delay the progression of liver fibrosis. The pharmacological substances are directly and rapidly absorbed through the decoction: polygonatum polysaccharides protect liver cell mitochondria function; volatile oil of agastache promotes gallbladder contraction and improves fat metabolism efficiency; imperata cylindrica reduces the toxicity of free fatty acids. The whole prescription comprehensively improves liver lipid metabolism disorder (reduces AST / ALT level by about 25%) and promotes fat mobilization (BMI decreases while fatty liver reverses), and cooperates with black pepper to enhance bioavailability and the "sugar blocking" effect of L-arabinose, to achieve synchronous improvement of body weight and liver damage.

[0087] Case Nine

[0088] Patient Wu, female, 57 years old. Complaint: severe central obesity (BMI 33.7), combined with abnormal fasting blood glucose, and obvious hard subcutaneous fat. Physical examination: tongue dark red, yellow thick and dry as accumulated powder, pulse stringy and astringent. Diagnosis: metabolic syndrome caused by damp-heat and blood stasis and toxin blocking liver and spleen meridians. Treatment: after taking the formula decoction of specific embodiment 3.3 of the application for 30 days, the body weight decreased by 8.5 kg, the BMI decreased to 30.9, the fasting blood glucose decreased from 6.8 mmol / L to 5.9 mmol / L, the subcutaneous fat softened, and the tongue fur turned thin yellow.

[0089] In summary, the formula of the present application all focuses on clearing heat and removing dampness. Curcumin, a food additive, is used for its anti-inflammatory and antioxidant effects. L-arabinose, a new resource food, is used for its effects of inhibiting the absorption and metabolism of sucrose and fat generation. The combination of the above-mentioned ingredients can synergistically improve the body's damp-heat environment, fat metabolism disorder and inflammation, fundamentally eliminate the pathogenic factors causing fat accumulation, and achieve the purpose of reducing fat. Moreover, the formula combines traditional Chinese medicine and western medicine, and the curative effect is better.

[0090] The above is only a preferred embodiment of the present application, and does not limit the present application in any form or substance. Any equivalent changes, modifications and evolution of the above-mentioned technical content made by those skilled in the art without departing from the scope of the technical solution of the present application are equivalent embodiments of the present application. Meanwhile, any equivalent changes, modifications and evolution of the above-mentioned technical content made by those skilled in the art without departing from the scope of the technical solution of the present application are equivalent embodiments of the present application.

Claims

1. A Chinese medicinal composition for removing dampness and reducing fat, comprising a therapeutically effective amount of polygonatum, dandelion, patchouli, curcumin, black pepper, and L-arabinose.

2. The Chinese medicine composition according to claim 1, further comprising Polygonatum odoratum, Bamboo Leaves, Imperata Rhizoma, Poria cocos, and Coix Seed.

3. The Chinese medicine composition according to claim 1, wherein the composition comprises, by weight, 9-15 parts of polygonatum, 10-15 parts of dandelion, 3-10 parts of patchouli, 500 mg of curcumin, 0.6-1.5 parts of black pepper, and 500 mg of L-arabinose.

4. The Chinese medicine composition according to claim 3, further comprising 6-12 parts of Polygonatum odoratum, 6-10 parts of Bamboo Leaves, 9-30 parts of Imperatae Rhizoma, 10-15 parts of Poria cocos, and 9-30 parts of Coix seeds, by weight.

5. The Chinese medicine composition according to claim 1, comprising, by weight, 12 parts of polygonatum, 12 parts of dandelion, 6 parts of patchouli, 500 mg of curcumin, 1.2 parts of black pepper, and 500 mg of L-arabinose.

6. The Chinese medicine composition according to claim 5, further comprising 9 parts of Polygonatum odoratum, 9 parts of Bamboo Leaves, 15 parts of Imperata cylindrica Rhizome, 12 parts of Poria cocos, and 15 parts of Coix seeds, by weight.

7. A Chinese medicine formula preparation, wherein the formula is the Chinese medicine composition according to any one of claims 1 to 6, wherein the Chinese medicine formula preparation is any one of a decoction, tablet, pill, capsule, powder, paste, granule or oral liquid.

8. Use of the Chinese medicine composition according to any one of claims 1 to 6, or the Chinese medicine formula preparation according to claim 7, in the preparation of a medicine for removing dampness and reducing fat.

9. A method for preparing a traditional Chinese medicine formula, comprising the following steps: The Chinese medicine composition according to any one of claims 1 to 6 is weighed, and 8 times the amount of water is added to the other drugs except curcumin, black pepper, and L-arabinose, and the mixture is decocted for 1.5 hours and filtered; 6 times the amount of water is added to the filter residue, and the mixture is decocted for 1 hour, filtered, and the two filtrates are mixed; the black pepper is ground into powder, and the curcumin and L-arabinose are added to the mixed filtrate and stirred thoroughly to obtain a decoction; or the decoction is further concentrated, dried, and crushed to obtain a powder; or an appropriate amount of dextrin and a flavoring agent are added, granulated, and packaged to obtain a granule; or the decoction is filled into a capsule shell to obtain a capsule.

Images