Brain vibration stimulation signal regulation and control method, system and device and storage medium

Abstract

The invention relates to the technical field of medical electronic systems, discloses a brain vibration stimulation signal regulation and control method and system, and is used for solving the problems that a brain vibration stimulation regulation and control system in the prior art is single in regulation and control method, regulation and control parameters cannot be adjusted according to needs, and the regulation and control cost is low. And the generated vibration stimulation signal cannot meet the requirement for diversity of nerve regulation and control. The method specifically comprises the steps of obtaining an intervention demand of brain vibration stimulation, and determining a vibration stimulation signal type according to the intervention demand; based on the vibration stimulation signal type, determining a vibration intervention unit distribution position required for generating the target vibration stimulation signal type and a vibration parameter of each vibration intervention unit; and controlling each vibration intervention unit to output a vibration signal based on the corresponding vibration parameter, and generating a brain vibration stimulation signal through interference cooperation of each vibration signal. According to the method, the brain vibration stimulation signal capable of meeting the nerve regulation diversity can be generated according to the stimulation requirement on the brain, and the efficiency of transmitting the subsequent vibration signal energy into the brain is improved.

Description

Technical Field

[0001] This invention relates to the field of medical electronic systems technology, and in particular to a method, system, electronic device, computer storage medium, and computer program product for modulating brain vibration stimulation signals. Background Technology

[0002] Vibration stimulation is widely used in neurophysiological and pathological interventions. For example, whole-body vibration stimulation can relieve stress, alleviate depression, and improve the motor abilities of patients with movement disorders; peripheral local vibration stimulation can inhibit pathological pain, and so on. In recent years, research has found that vibration can also be applied to the head. By targeting the brain with specific waveforms, interventional stimulation can achieve neuromodulation effects to some extent. Compared to other parts of the body, the brain is a mechanically sensitive organ, and the mechanomechanical properties of neurons are one of the important factors in maintaining their normal function. Mechanosensitive channels are widely distributed on the neuronal cell membrane. These channels respond to changes in the extracellular mechanical environment, mediating the influx of ions, activating intracellular biochemical circuits, and influencing neurophysiological / pathological processes (such as development and regeneration, neurovascular function, etc.). Several studies on vibration of brain neurons have shown that vibration can affect functional systems such as the immune system and mood; therefore, vibration stimulation of the brain is of great significance for the regulation of brain function.

[0003] In existing technologies, most solutions for regulating brain function through vibration stimulation are based on massage, typically using low-frequency mechanical vibration to achieve relaxation and pain relief. The overall vibration method is relatively simple, and the effects it can achieve are also relatively limited. It cannot provide a plastic vibration stimulation adjustment method, cannot respond to complex intervention and regulation needs, and the generated vibration signals do not match the diversity of neural activity, thus resulting in poor neuromodulation effects. Summary of the Invention

[0004] The main objective of this invention is to solve the technical problems of existing brain vibration stimulation modulation systems, which have relatively simple modulation methods, cannot adjust modulation parameters as needed, and cannot meet the diverse needs of neural modulation.

[0005] The first aspect of the present invention provides a method for modulating brain vibration stimulation signals, comprising: acquiring intervention requirements for brain vibration stimulation, and determining the type of vibration stimulation signal based on the intervention requirements;

[0006] Based on the vibration stimulation signal type, determine the distribution location of the vibration intervention units required to generate the target vibration stimulation signal type and the vibration parameters of each vibration intervention unit;

[0007] Each vibration intervention unit is controlled to output a vibration signal based on the corresponding vibration parameters, and a brain vibration stimulation signal is generated through the interference and coordination of the vibration signals.

[0008] Optionally, in a first implementation of the first aspect of the present invention, determining the distribution locations of the vibration intervention units required to generate the target vibration stimulation signal type based on the vibration stimulation signal type includes:

[0009] When the vibration stimulation signal type is a whole-brain dimension stimulation signal, the distribution position of the vibration intervention unit is determined based on the preset lead system;

[0010] When the vibration stimulation signal is a targeted stimulation signal for a specific brain region, a three-dimensional head model is constructed based on medical imaging data, and the distribution location of the vibration intervention unit is determined by simulation based on the three-dimensional head model.

[0011] Optionally, in a second implementation of the first aspect of the present invention, the step of constructing a three-dimensional head model based on medical imaging data and determining the distribution location of the vibration intervention unit through simulation based on the three-dimensional head model includes:

[0012] Obtain brain MRI images and then obtain the three-dimensional coordinates of the target area to be stimulated in the standard coordinate system through image registration.

[0013] Construct a multi-tissue conductivity model that includes the skull, cerebrospinal fluid, and brain tissue;

[0014] Based on the multi-tissue conductivity model provided by the user, the distribution of electric field intensity in the target area to be stimulated under different vibration module configurations is calculated, and the distribution position of the vibration intervention unit is determined according to the electric field intensity distribution.

[0015] Optionally, in a third implementation of the first aspect of the present invention, controlling each of the vibration intervention units to output vibration signals based on the corresponding vibration parameters, and generating brain vibration stimulation signals through the interference and coordination of the vibration signals, includes:

[0016] Each vibration intervention unit is controlled to output a first vibration signal and a second vibration signal based on the corresponding vibration parameters.

[0017] An envelope signal is generated by the interference superposition of the first vibration signal and the second vibration signal.

[0018] Optionally, in a fourth implementation of the first aspect of the present invention, the signal frequency parameters, amplitude parameters, and duty cycle of each vibration intervention unit are specified.

[0019] When the first vibration signal and the second vibration signal interfere and superimpose to generate the envelope signal, the expression for interference superposition is:

[0020]

[0021] f2 = f1 + Δf;

[0022] Where f1 and f2 are the frequency parameters of the first vibration signal and the second vibration signal, respectively, and A1 and A2 are the amplitude parameters of the first vibration signal and the second vibration signal, respectively. Δf is a rectangular pulse function used to control the range of stimulus duty cycle, where Δf is the frequency difference, and the value of the frequency difference ranges from 0 to 100 Hz.

[0023] Optionally, in a fifth implementation of the first aspect of the present invention, the intervention position of the vibration intervention unit is the left temporal region and the right temporal region or the left frontal pole and the right frontal pole.

[0024] A second aspect of the present invention provides a brain vibration stimulation signal modulation system, characterized in that it comprises:

[0025] The demand acquisition module is used to acquire the intervention demand for brain vibration stimulation and determine the vibration stimulation signal type based on the intervention demand.

[0026] The signal construction module is used to determine the distribution location of the vibration intervention units required to generate the target vibration stimulation signal type and the vibration parameters of each vibration intervention unit based on the vibration stimulation signal type.

[0027] The signal generation module is used to control each of the vibration intervention units to output vibration signals based on the corresponding vibration parameters, and to generate brain vibration stimulation signals through the interference and coordination of the vibration signals.

[0028] A third aspect of the present invention provides a brain vibration stimulation signal modulation device, comprising: a memory and at least one processor, wherein the memory stores instructions; the at least one processor invokes the instructions in the memory to cause the brain vibration stimulation signal modulation device to perform the steps of the brain vibration stimulation signal modulation method described above.

[0029] A fourth aspect of the present invention provides a computer-readable storage medium storing instructions that, when executed on a computer, cause the computer to perform the steps of the brain vibration stimulation signal modulation method described above.

[0030] A fifth aspect of the present invention provides a computer program product comprising a computer program / instructions, characterized in that, when the computer program / instructions are executed by a processor, the steps of the brain vibration stimulation signal modulation method described above are implemented.

[0031] The technical solution provided by this invention involves obtaining the intervention requirements for brain vibration stimulation, determining the type of vibration stimulation signal based on the intervention requirements, determining the distribution locations of vibration intervention units and the vibration parameters of each vibration intervention unit required to generate the target vibration stimulation signal type based on the vibration stimulation signal type, controlling each vibration intervention unit to output a vibration signal based on the corresponding vibration parameters, and generating a brain vibration stimulation signal through the interference and coordination of each vibration signal. This method can automatically adjust the vibration stimulation signal according to the stimulation requirements of the brain, and can generate signals that can meet the diversity of neural regulation. The system, electronic device, computer-readable storage medium, and computer program product provided by this invention also solve the corresponding technical problems. Attached Figure Description

[0032] The accompanying drawings, which are included to provide a further understanding of this application and form part of this application, illustrate exemplary embodiments and are used to explain this application, but do not constitute an undue limitation of this application. In the drawings:

[0033] Figure 1 This is a flowchart illustrating the first embodiment of the brain vibration stimulation signal modulation method according to the present invention.

[0034] Figure 2 This is a flowchart illustrating the second embodiment of the brain vibration stimulation signal modulation method in this invention.

[0035] Figure 3 This is a schematic diagram of the 10-20 international standard lead system for locating the vibration intervention unit in the brain vibration stimulation signal modulation method of this invention.

[0036] Figure 4 This is a schematic diagram illustrating a specific example of the memory intervention effect of the brain vibration stimulation signal modulation method in this invention.

[0037] Figure 5 This is a flowchart illustrating the third embodiment of the brain vibration stimulation signal modulation method in this invention.

[0038] Figure 6 This is a schematic diagram illustrating a specific example of the sleep intervention effect of the brain vibration stimulation signal modulation method in an embodiment of the present invention;

[0039] Figure 7 This is a schematic diagram of one embodiment of the brain vibration stimulation signal modulation system in this invention;

[0040] Figure 8 This is a schematic diagram of one embodiment of the brain vibration stimulation signal modulation device according to the present invention;

[0041] Figure 9This is a schematic diagram illustrating the principle of a computer-readable medium according to an embodiment of the present invention. Detailed Implementation

[0042] Exemplary embodiments of the invention will now be described more fully with reference to the accompanying drawings. However, these exemplary embodiments can be implemented in many forms and should not be construed as limiting the invention to the embodiments set forth herein. Rather, these exemplary embodiments are provided to make the invention more comprehensive and complete, and to facilitate a full communication of the inventive concept to those skilled in the art. The same reference numerals in the drawings denote the same or similar elements, components, or parts, and therefore repeated descriptions of them will be omitted.

[0043] Subject to the technical concept of this invention, the features, structures, characteristics or other details described in a particular embodiment may be combined in one or more other embodiments in a suitable manner.

[0044] In the description of specific embodiments, the features, structures, characteristics, or other details described in this invention are intended to enable those skilled in the art to fully understand the embodiments. However, it is not excluded that those skilled in the art can practice the technical solutions of this invention without one or more of the specific features, structures, characteristics, or other details.

[0045] The flowcharts shown in the accompanying drawings are merely illustrative and do not necessarily include all content and operations / steps, nor do they necessarily have to be performed in the described order. For example, some operations / steps can be broken down, while others can be combined or partially combined; therefore, the actual execution order may change depending on the specific circumstances.

[0046] The block diagrams shown in the accompanying drawings are merely functional entities and do not necessarily correspond to physically independent entities. That is, these functional entities can be implemented in software, in one or more hardware modules or integrated circuits, or in different network and / or processor devices and / or microcontroller devices.

[0047] The terms “and / or” or “and / or” include all combinations of any one or more of the listed items.

[0048] See also Figure 1 The first embodiment of the brain vibration stimulation signal modulation method in this invention includes:

[0049] S101. Obtain the intervention requirements for brain vibration stimulation, and determine the type of vibration stimulation signal based on the intervention requirements;

[0050] It is understood that the executing entity of this invention can be a brain vibration stimulation signal modulation system, a terminal, or a server; no specific limitation is made here. This embodiment of the invention will be described using a server as an example.

[0051] The brain vibration stimulation signal modulation method described in this embodiment is specifically used to regulate and intervene in brain function. It can be used to generate specific vibration stimulation signals for various different intervention needs. Therefore, before constructing and outputting specific signals, the intervention needs for brain vibration stimulation must first be obtained. The intervention needs for brain vibration stimulation can include whole-brain intervention and specific brain region intervention. Among them, whole-brain intervention can include vibration stimulation of the whole brain region, such as promoting sleep, and specific brain region intervention includes stimulation of local brain regions, such as the hippocampus region of Alzheimer's patients.

[0052] Therefore, the type of vibration stimulation signal to be generated can be determined based on the specific intervention requirements of this brain vibration stimulation. Before obtaining the specific intervention requirements, a pre-configured vibration stimulation signal type database is included, which pre-stores specific stimulation signal types corresponding to various intervention requirements. For example, specific intervention requirements for brain vibration stimulation can be input or uploaded to the server. These requirements can include various aspects such as "promoting sleep," "relieving anxiety," and "improving memory," and the corresponding vibration stimulation signal type can be searched in the pre-configured database based on the requirements.

[0053] In one specific implementation, the method in this embodiment can be implemented by a wearable device worn on the user's head and a control device that is communicatively linked to the wearable device. The control device can be a mobile terminal, and specifically, it can be implemented by installing an application to regulate various stimulation signals.

[0054] S102. Based on the type of vibration stimulus signal, determine the distribution location of vibration intervention units required to generate the target vibration stimulus signal type and the vibration parameters of each vibration intervention unit;

[0055] After obtaining the specific vibration stimulus type to be generated, this embodiment determines the distribution locations of vibration intervention units and the vibration parameters of each vibration intervention unit required to generate the target vibration stimulus signal type based on the selected specific vibration stimulus signal type. The vibration intervention unit can be a vibrator that contacts the user's head, providing single-point, single-area output with wide bandwidth (effective bandwidth of 0.1-1MHz) and high energy (0-50W) vibration stimulation. Each vibration intervention unit may include a conversion module and one or more vibrators. The conversion module receives the signal input and performs signal denoising, power amplification, and digital-to-analog conversion to generate a mechanical vibration signal, which is then output by the vibrator and transmitted to the human body.

[0056] Specifically, in this embodiment, the generation of the target vibration stimulus signal is achieved through a vibration intervention unit set on the user's wearable device. The distribution location of the target vibration intervention unit and the corresponding vibration parameters can be determined according to the specific type of vibration stimulus to be generated. Each vibration intervention unit can output vibration signals with different vibration parameters synchronously or in a time-sharing manner as needed. The vibration parameters include signal frequency parameters, amplitude parameters, and duty cycle.

[0057] The signal frequency parameters include three different types of signals, as detailed below:

[0058] (1) Low-frequency signals: The frequency range is 0.1-100Hz, which can regulate neuronal synchronization and enhance or inhibit specific neural activities;

[0059] (2) Intermediate frequency signal: The frequency range is 100-1kHz. It can suppress abnormal discharges in some diseases, including epilepsy, and can also be used as a signal input for difference frequency signal and carrier signal.

[0060] (3) High-frequency signal: The frequency range is 1kHz-1MHz. It can regulate neuronal activity through mechanical and thermal effects. At the same time, high-frequency signal has a better focusing effect than the other two types of signals.

[0061] The amplitude parameter is used to adjust the intensity of the vibration stimulation, and the duty cycle is used to adjust the effectiveness of the vibration stimulation. By dynamically adjusting the above parameters, the full frequency band requirements of neural activity can be covered, solving the problem of the single frequency band limitation of traditional technologies.

[0062] S103. Control each vibration intervention unit to output vibration signals based on the corresponding vibration parameters, and generate brain vibration stimulation signals through the interference and coordination of each vibration signal.

[0063] Subsequently, based on the specific vibration parameters obtained in the preceding steps, the vibration signals output by each vibration unit can be controlled, and brain stimulation signals can be generated based on the interference, synergistic effect, or a combination of both of the vibration signals. Furthermore, based on the control method described in this embodiment, various types of brain stimulation signals can be generated based on different control parameters to achieve the regulation and intervention of the brain and brain function.

[0064] In one specific embodiment, when the intervention requirement is "promoting sleep," a corresponding vibration stimulation signal type of whole-brain stimulation is found in a preset database. The required vibration intervention unit can then be set to all vibration units, with the vibration parameters being diffuse whole-brain stimulation, ensuring the vibration is not focused on a specific area, and adjusting the duty cycle to a preset sleep intervention level. During actual intervention, all vibration intervention units are controlled to output vibration signals based on the corresponding vibration parameters to work collaboratively, achieving diffuse stimulation of the whole brain, realizing sleep intervention, promoting user sleep, and regulating sleep quality.

[0065] In one specific embodiment, when the intervention requirement is "improving memory," a corresponding vibration stimulation signal type for a specific region is found in a preset database. The required vibration intervention unit can then select the target vibration unit based on the specific location of the stimulus, and the vibration parameters are calculated based on the actual parameters sensitive to the specific location of the stimulus. During actual intervention, the corresponding vibration intervention unit is controlled to output a specific vibration signal based on the corresponding vibration parameters, thereby stimulating brain and memory-related areas and promoting improved memory.

[0066] The solution in this invention can adjust and regulate the parameters of the vibration stimulation signal as needed according to the stimulation requirements of the brain, generating a variety of signals that can meet the diverse needs of neural regulation. This enables functional intervention under various frequency band requirements, including spatial distribution, energy, and rhythm in the superficial, middle, and deep parts of the brain. Furthermore, this solution integrates low, medium, and high frequency generation capabilities, generating intervention signals sensitive to specific regions according to specific needs, thereby improving the efficiency of energy transmission into the cranium and achieving neural regulation of the brain.

[0067] Please refer to Figure 2-Figure 4 The second embodiment of the brain vibration stimulation signal modulation method in this invention includes:

[0068] S201. Obtain the intervention requirements for brain vibration stimulation, and determine the type of vibration stimulation signal based on the intervention requirements;

[0069] The specific solution in S201 of this embodiment is basically the same as that in S101 of the previous embodiment, so it will not be repeated here. In particular, this embodiment takes the intervention need of "improving memory" for Alzheimer's patients as an example for explanation.

[0070] S202. When the vibration stimulation signal type is a targeted stimulation signal for a specific brain region, a three-dimensional head model is constructed based on medical imaging data, and the distribution position of the vibration intervention unit is determined by simulation based on the three-dimensional head model.

[0071] S203. Based on the type of vibration stimulus signal, determine the vibration parameters of each vibration intervention unit;

[0072] In this embodiment, when the intervention requirement is "improving memory", the brain function intervention requirement focuses on the hippocampus as a specific target area, and intervention for Alzheimer's disease can be achieved by stimulating the hippocampus with vibration.

[0073] Since this embodiment requires intervention on a specific hippocampal region, to ensure precise intervention locations for different users, specific hippocampal coordinates can be set for each user. The distribution of vibration intervention units is then determined based on these coordinates. Specifically, this includes: acquiring brain MRI images; obtaining three-dimensional coordinates of the target area under a standard coordinate system through image registration; constructing a multi-tissue conductivity model encompassing the skull, cerebrospinal fluid, and brain tissue; calculating the electric field intensity distribution of the target area under different vibration module configurations based on the user's multi-tissue conductivity model; and determining the distribution of vibration intervention units based on the electric field intensity distribution.

[0074] Specifically, 3D T1-weighted MRI can be used to scan high-resolution structural images of the patient's head, obtaining the distribution of the skull, cerebrospinal fluid, and gray or white matter, as well as the precise coordinates of the hippocampus. For example, in the MNI (Montreal Neurological Institute) coordinate system, one coordinate of the hippocampus can be (x, y, z), where x = 20 mm, y = -10 mm, and z = -20 mm. The MRI data is then imported into simulation software (such as COMSOL multiphysics simulation software) to generate a three-dimensional mesh model containing the skull, cerebrospinal fluid, and gray / white matter. Based on this three-dimensional mesh model, the conductivity of each tissue is set (e.g., brain tissue: 0.33 S / m, scalp: 0.465 S / m), while the scalp surface is set as an electrically insulating boundary to simulate the real physiological environment. Based on the simulated environment, brain stimulation signals are designed to generate a multi-tissue conductivity model of the brain.

[0075] In one specific implementation, after obtaining the multi-tissue conductivity model, a relationship model between the stimulation signal and envelope signal of the vibration intervention unit can be constructed based on the influence of the vibration signal generated by the actual vibration intervention unit on each part of the multi-tissue conductivity model. This model describes the influence relationship and connection between the stimulation signal and the output envelope signal of each vibration intervention unit. Specifically, various stimulation signals can be applied by each vibration intervention unit, and the influence of the stimulation signal on each part of the multi-tissue conductivity model can be determined based on the relationship model. This can be achieved by collecting samples from actual stimulation signals and training the relationship model based on the samples, or by combining a mathematical calculation model to establish the relationship model. Similarly, the vibration parameters of each vibration intervention unit can be determined in reverse based on this relationship model when a specific type of vibration stimulation signal is required.

[0076] In a specific example, a mathematical calculation model can be run using computational software to calculate the electric field intensity distribution at the hippocampus location in a multi-tissue conductivity model under different vibration intervention unit configurations. This determines the specific location of the vibration intervention unit and the corresponding vibration parameters required to generate a sufficiently strong 40Hz envelope electric field (e.g., ≥0.2V / m) in the hippocampus region.

[0077] S204. Control each vibration intervention unit to output the first vibration signal and the second vibration signal based on the corresponding vibration parameters.

[0078] S205. An envelope signal is generated by the interference superposition of the first vibration signal and the second vibration signal.

[0079] In one specific implementation, the desired envelope signal is generated by interfering with the first and second vibration signals input by different vibration intervention units. The following explanation focuses on generating a sufficiently strong 40Hz envelope signal in the hippocampal region:

[0080] Specifically, when generating the envelope signal through the interference superposition of the first and second vibration signals, the expression for interference superposition is:

[0081]

[0082] f2 = f1 + Δf;

[0083] Wherein, cos(2πf1t) and cos(2π(f2)t) represent two signals generated by the multi-band signal generation module, with cos(2πf1t) being the first signal and cos(2π(f2)t) being the second signal; f1 and f2 are the frequency parameters of the two vibration signals, with f1 representing the frequency parameter of the first signal and f2 representing the frequency parameter of the second signal; A1 and A2 are the amplitude parameters of the two vibration signals, with A1 representing the amplitude parameter of the first signal and A2 representing the amplitude parameter of the second signal, and the amplitude parameters of the vibration signals range from 10% to 100%. is a rectangular pulse function used to control the duty cycle range of the stimulus, specifically between 10% and 100%; Δf is the frequency difference between the frequency parameters of the first signal and the frequency parameters of the second signal, with the value of the frequency difference ranging from 0 to 100 Hz.

[0084] When Δf is 0, the two signals are identical, and no interference occurs between them. In this case, f1 can be set to a low frequency to provide diffuse stimulation to the whole brain. When Δf is not 0, the superposition of signals of different frequencies produces a difference frequency effect, or the amplitude of a high-frequency carrier is modulated by a low-frequency signal to generate a composite signal containing a low-frequency envelope. In one specific implementation scenario, f1 is set to 400Hz and f2 to 440Hz; in another specific implementation scenario, f1 is set to 2kHz and f2 to 2.04kHz. Based on the above interference superposition expression, a low-frequency envelope signal with an envelope signal of 40Hz can be generated at the corresponding location. Please refer to the appendix. Figure 3 The specific location of the vibration intervention unit can be determined based on the location shown in the international 10-20 system; in this embodiment, the left temporal region T3 and the right temporal region T4 can be selected as intervention sites.

[0085] In practical applications, because high-frequency stimulation can penetrate surface tissues and converge in deeper layers, thereby generating low-frequency modulated signals that neurons can respond to, signal interference can focus on activating deep brain regions without significantly affecting cortical function. In one specific implementation, the frequency, amplitude, and duty cycle of the signal can also be adjusted in real time according to user needs.

[0086] For details, please refer to the appendix. Figure 4 In this embodiment, memory intervention was also performed on test subjects. Memory tests were conducted on users in the control group without memory intervention and the intervention group with memory intervention, and scores were calculated to determine the memory improvement effect. It can be seen that vibration intervention improved users' memory to a certain extent.

[0087] The solution in this invention can automatically adjust the vibration stimulation signal according to the stimulation needs of the brain. It can combine vibration signal interference to generate signals that meet the intervention needs of specific brain regions, thereby achieving functional intervention on specific brain regions and functions. It can solve the problems of insufficient penetration depth and poor targeting in traditional techniques through interference and synergistic mechanisms, further addressing the technical problem of low energy transfer efficiency in existing intervention schemes. It can meet the needs of neuromodulation scenarios with different intervention requirements. Simultaneously, by adjusting multiple parameters, it overcomes the technical bottlenecks of existing schemes where the adjustment parameters are singular and cannot be adjusted in real time.

[0088] Please refer to Figure 3 , Figure 5 as well as Figure 6 The third embodiment of the brain vibration stimulation signal modulation method in this invention includes:

[0089] S301. Obtain the intervention requirements for brain vibration stimulation, and determine the type of vibration stimulation signal based on the intervention requirements;

[0090] The content of step S301 in this embodiment is basically the same as that of step S101 in the previous embodiment, so it will not be repeated here. In this embodiment, the intervention requirement is the whole brain dimension stimulation requirement as an example. The most typical intervention scenario is the need to "promote sleep". At this time, the vibration stimulation signal type is the whole brain dimension diffuse stimulation signal.

[0091] S302. When the vibration stimulation signal type is a whole-brain dimension stimulation signal, the distribution position of the vibration intervention unit is determined based on the preset lead system, and the vibration parameters of each vibration intervention unit are calculated according to the whole-brain dimension stimulation signal.

[0092] When the vibration stimulation signal is a diffuse stimulation signal of the whole brain dimension, there are no obvious requirements for the number and location of the vibration intervention units by default. All vibration intervention units are used by default. Alternatively, a specific number of vibration intervention units can be selected according to the user's tolerance. This is because sleep is a process in which the level of arousal gradually decreases. It is a macroscopic process that takes place in the whole brain and does not require focusing on a specific intervention location.

[0093] Please see the attached Figure 3 In one specific implementation, the specific location of the vibration intervention unit can be determined based on the locations shown in the international 10-20 system. However, in another specific implementation, the user's forehead can be preferred as the intervention location, with stimulation target points set at both the left and right frontal poles of the forehead to minimize the user's burden. Figure 3 The positions of Fp1 and Fp2.

[0094] When calculating the vibration parameters of each vibration intervention unit based on the whole-brain dimension stimulation signal, the vibration amplitude parameters can be adjusted in combination with the user's settings. In addition, in this embodiment, the vibration parameters with the best sleep intervention effect can also be selected based on the data collected from the pre-conducted sleep intervention test.

[0095] In one specific implementation, to generate diffuse stimulation of the whole brain, Δf is set to 0 so that the vibration module intervention does not focus on a specific area; the vibration amplitude parameter is preferably set to 60% to avoid side effects such as dizziness and nausea; the duty cycle is set to 50% to maximize the sleep intervention effect.

[0096] S303. Control each vibration intervention unit to output vibration signals based on the corresponding vibration parameters, and generate brain vibration stimulation signals through the interference and coordination of each vibration signal.

[0097] After obtaining the specific vibration parameters, each vibration intervention unit can be controlled to output vibration signals based on the corresponding vibration parameters, and the whole brain can be diffusely stimulated based on the synergy between the vibration signals, thereby performing sleep intervention.

[0098] See also Figure 6 In this embodiment, the specific method involves conducting pre-sleep vibration intervention on specific test subjects and collecting sleep reports. Adaptation records are kept from days 0 to 71, and a four-week vibration intervention is performed from days 8 to 35. According to... Figure 6 As shown in (a), vibration intervention effectively reduced nighttime wakefulness time. Figure 6 As shown in (b), vibration intervention effectively improved sleep efficiency, and according to... Figure 6 As shown in (c), vibration intervention effectively reduced the time to fall asleep.

[0099] The solution in this embodiment of the invention can automatically adjust the vibration stimulation signal according to the stimulation needs of the brain. It can combine the vibration signal to generate a signal that can meet the specific intervention needs of the brain, thereby realizing functional intervention of specific brain functions, while improving the efficiency of energy transmission into the cranium and realizing the neuromodulation of the brain.

[0100] The brain vibration stimulation signal modulation method in the embodiments of the present invention has been described above. The brain vibration stimulation signal modulation system in the embodiments of the present invention is described below. Please refer to [link / reference]. Figure 7 One embodiment of the brain vibration stimulation signal modulation system in this invention includes:

[0101] The demand acquisition module 701 is used to acquire the intervention demand for brain vibration stimulation and determine the vibration stimulation signal type based on the intervention demand.

[0102] The signal construction module 702 is used to determine the distribution location of the vibration intervention units required to generate the target vibration stimulation signal type and the vibration parameters of each vibration intervention unit based on the vibration stimulation signal type.

[0103] The signal generation module 703 is used to control each of the vibration intervention units to output vibration signals based on the corresponding vibration parameters, and to generate brain vibration stimulation signals through the interference and coordination of the vibration signals.

[0104] The system is capable of adjusting and regulating the parameters of the vibration stimulation signal as needed according to the stimulation requirements of the brain, and can generate a variety of signals that can meet the diversity of neural regulation.

[0105] In another embodiment of this application, the signal construction module 702 is specifically used for:

[0106] When the vibration stimulation signal type is a whole-brain dimension stimulation signal, the distribution position of the vibration intervention unit is determined based on the preset lead system;

[0107] When the vibration stimulation signal is a targeted stimulation signal for a specific brain region, a three-dimensional head model is constructed based on medical imaging data, and the distribution location of the vibration intervention unit is determined by simulation based on the three-dimensional head model.

[0108] In another embodiment of this application, the step of constructing a three-dimensional head model based on medical imaging data and determining the distribution location of the vibration intervention unit through simulation based on the three-dimensional head model includes:

[0109] Obtain brain MRI images and then obtain the three-dimensional coordinates of the target area to be stimulated in the standard coordinate system through image registration.

[0110] Construct a multi-tissue conductivity model that includes the skull, cerebrospinal fluid, and brain tissue;

[0111] Based on the multi-tissue conductivity model provided by the user, the distribution of electric field intensity in the target area to be stimulated under different vibration module configurations is calculated, and the distribution position of the vibration intervention unit is determined according to the electric field intensity distribution.

[0112] In another embodiment of this application, the signal generation module 703 is specifically used for:

[0113] Each vibration intervention unit is controlled to output a first vibration signal and a second vibration signal based on the corresponding vibration parameters.

[0114] An envelope signal is generated by the interference superposition of the first vibration signal and the second vibration signal.

[0115] In another embodiment of this application, the signal frequency parameters, amplitude parameters, and duty cycle of each vibration intervention unit are specified.

[0116] When the first vibration signal and the second vibration signal interfere and superimpose to generate an envelope signal, the expression for interference superposition is:

[0117]

[0118] f2 = f1 + Δf;

[0119] Where s(t) represents the generated envelope signal, f1 and f2 are the frequency parameters of the first vibration signal and the second vibration signal, respectively, and A1 and A2 are the amplitude parameters of the first vibration signal and the second vibration signal, respectively. Δf is a rectangular pulse function used to control the range of stimulus duty cycle, where Δf is the frequency difference, and the value of the frequency difference ranges from 0 to 100 Hz.

[0120] In another embodiment of this application, the intervention position of the vibration intervention unit is the left and right temporal regions or the left and right frontal poles.

[0121] Furthermore, the specific scheme of the system in this embodiment of the invention for executing the brain vibration stimulation signal modulation method can be found in the foregoing method embodiments, and therefore will not be repeated here.

[0122] The system in this embodiment of the invention can automatically adjust the vibration stimulation signal as needed according to the stimulation requirements of the brain, and can generate signals that can meet the diversity of neural regulation, thereby realizing functional intervention on the brain and brain function.

[0123] Based on the same inventive concept, this specification also provides an electronic device for modulating brain vibration stimulation signals. The electronic device for modulating brain vibration stimulation signals in this embodiment of the invention will be described in detail below from the perspective of hardware processing.

[0124] Figure 8 This is a schematic diagram of an electronic device provided as an embodiment of this specification. Refer to the following... Figure 8 To describe the electronic device 800 according to this embodiment of the invention. Figure 8 The electronic device 800 shown is merely an example and should not impose any limitations on the functionality and scope of use of the embodiments of the present invention.

[0125] like Figure 8 As shown, the electronic device 800 is presented in the form of a general-purpose computing device. The components of the electronic device 800 may include, but are not limited to: at least one processing unit 810, at least one storage unit 820, a bus 830 connecting different system components (including storage unit 820 and processing unit 810), a display unit 840, etc.

[0126] The storage unit stores program code that can be executed by the processing unit 810, causing the processing unit 810 to perform the steps described in the processing method section of this specification according to various exemplary embodiments of the present invention. For example, the processing unit 810 can perform, as follows: Figure 1 , 2 or Figure 5 The steps of the method shown.

[0127] The storage unit 820 may include a readable medium in the form of a volatile storage unit, such as a random access memory unit (RAM) 8201 and / or a cache storage unit 8202, and may further include a read-only memory unit (ROM) 8203.

[0128] The storage unit 820 may also include a program / utility 8204 having a set (at least one) program module 8205, such program module 8205 including but not limited to: an operating system, one or more application programs, other program modules and program data, each or some combination of these examples may include an implementation of a network environment.

[0129] Bus 830 can represent one or more of several types of bus structures, including a memory cell bus or memory cell controller, a peripheral bus, a graphics acceleration port, a processing unit, or a local bus using any of the various bus structures.

[0130] Electronic device 800 can also communicate with one or more external devices 100 (e.g., keyboard, pointing device, Bluetooth device, etc.), and with one or more devices that enable a user to interact with the electronic device 800, and / or with any device that enables the electronic device 800 to communicate with one or more other computing devices (e.g., router, modem, etc.). This communication can be performed via input / output (I / O) interface 850. Furthermore, electronic device 800 can also communicate with one or more networks (e.g., local area network (LAN), wide area network (WAN), and / or public networks, such as the Internet) via network adapter 860. Network adapter 860 can communicate with other modules of electronic device 800 via bus 830. It should be understood that, although... Figure 8 As not shown in the diagram, other hardware and / or software modules may be used in conjunction with the electronic device 800, including but not limited to: microcode, device drivers, redundant processing units, external disk drive arrays, RAID systems, tape drives, and data backup storage systems.

[0131] Through the above description of the embodiments, those skilled in the art will readily understand that the exemplary embodiments described in this invention can be implemented by software or by combining software with necessary hardware. Therefore, the technical solutions according to the embodiments of this invention can be embodied in the form of a software product, which can be stored in a computer-readable storage medium (such as a CD-ROM, USB flash drive, external hard drive, etc.) or on a network, including several instructions to cause a computing device (such as a personal computer, server, or network device, etc.) to execute the method described above according to this invention. When the computer program is executed by a data processing device, it enables the computer-readable medium to implement the steps of the method described above, i.e.: as... Figure 1 , 2 or Figure 5 The steps of the method shown.

[0132] Figure 8 This is a schematic diagram of a computer-readable medium provided for embodiments of this specification.

[0133] accomplish Figure 1 , 2 or Figure 5 The computer program of the method shown can be stored on one or more computer-readable media. A computer-readable medium can be a readable signal medium or a readable storage medium. A readable storage medium can be, for example, but not limited to, an electrical, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or any combination thereof. More specific examples of readable storage media (a non-exhaustive list) include: an electrical connection having one or more wires, a portable disk, a hard disk, random access memory (RAM), read-only memory (ROM), erasable programmable read-only memory (EPROM or flash memory), optical fiber, portable compact disk read-only memory (CD-ROM), optical storage device, magnetic storage device, or any suitable combination thereof.

[0134] The computer-readable storage medium may include a data signal propagated in baseband or as part of a carrier wave, wherein the readable program code is carried. The data signal propagated may take a variety of forms, including but not limited to electromagnetic signals, optical signals, or any suitable combination thereof. The readable storage medium may also be any readable medium other than a readable storage medium, which may send, propagate, or transmit a program for use by or in conjunction with an instruction execution system, device, or component. The program code contained on the readable storage medium may be transmitted using any suitable medium, including but not limited to wireless, wired, optical cable, RF, etc., or any suitable combination thereof.

[0135] Program code for performing the operations of this invention can be written in any combination of one or more programming languages, including object-oriented programming languages ​​such as Java and C++, and conventional procedural programming languages ​​such as C or similar languages. The program code can execute entirely on the user's computing device, partially on the user's device, as a standalone software package, partially on the user's computing device and partially on a remote computing device, or entirely on a remote computing device or server. In cases involving remote computing devices, the remote computing device can be connected to the user's computing device via any type of network, including a local area network (LAN) or a wide area network (WAN), or it can be connected to an external computing device (e.g., via the Internet using an Internet service provider).

[0136] In summary, this invention can be implemented in hardware, or as software modules running on one or more processors, or a combination thereof. Those skilled in the art will understand that in practice, general-purpose data processing devices such as microprocessors or digital signal processors (DSPs) can be used to implement some or all of the functions of some or all of the components according to the embodiments of the invention. The invention can also be implemented as a device or apparatus program (e.g., a computer program and computer program product) for performing part or all of the methods described herein. Such programs implementing the invention can be stored on a computer-readable medium or can take the form of one or more signals. Such signals can be downloaded from an Internet website, provided on a carrier signal, or provided in any other form.

[0137] The specific embodiments described above further illustrate the purpose, technical solution, and beneficial effects of the present invention. It should be understood that the present invention is not inherently related to any specific computer, virtual device, or electronic device, and various general-purpose devices can also implement the present invention. The above descriptions are merely specific embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

[0138] The various embodiments in this specification are described in a progressive manner. The same or similar parts between the various embodiments can be referred to each other. Each embodiment focuses on describing the differences from other embodiments.

[0139] If the technical solution of this application involves personal information, the product using this technical solution has clearly informed the user of the personal information processing rules and obtained the user's voluntary consent before processing the personal information. If the technical solution of this application involves sensitive personal information, the product using this technical solution has obtained the user's separate consent before processing the sensitive personal information, and also meets the requirement of "express consent". For example, at personal information collection devices such as cameras, clear and prominent signs are set up to inform users that they have entered the scope of personal information collection and that personal information will be collected. If an individual voluntarily enters the collection scope, it is deemed that they have agreed to the collection of their personal information; or on the personal information processing device, with clear signs / information informing users of the personal information processing rules, authorization is obtained from the individual through pop-up information or by asking the individual to upload their personal information; wherein, the personal information processing rules may include information such as the personal information processor, the purpose of personal information processing, the processing method, and the types of personal information processed.

[0140] The above description is merely an embodiment of this application and is not intended to limit the scope of this application. Various modifications and variations can be made to this application by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this application should be included within the scope of the claims of this application.

Claims

1. A method for modulating brain vibration stimulation signals, characterized in that, include: Obtain the intervention requirements for brain vibration stimulation, and determine the type of vibration stimulation signal based on the intervention requirements; Based on the vibration stimulation signal type, determine the distribution location of the vibration intervention units required to generate the target vibration stimulation signal type and the vibration parameters of each vibration intervention unit; Each vibration intervention unit is controlled to output a vibration signal based on the corresponding vibration parameters, and a brain vibration stimulation signal is generated through the interference and coordination of the vibration signals.

2. The method for modulating brain vibration stimulation signals according to claim 1, characterized in that, The determination of the vibration intervention unit distribution locations required to generate the target vibration stimulation signal type based on the vibration stimulation signal type includes: When the vibration stimulation signal type is a whole-brain dimension stimulation signal, the distribution position of the vibration intervention unit is determined based on the preset lead system; When the vibration stimulation signal is a targeted stimulation signal for a specific brain region, a three-dimensional head model is constructed based on medical imaging data, and the distribution location of the vibration intervention unit is determined by simulation based on the three-dimensional head model.

3. The method for modulating brain vibration stimulation signals according to claim 2, characterized in that, The process of constructing a three-dimensional head model based on medical imaging data and determining the distribution location of vibration intervention units through simulation based on the three-dimensional head model includes: Obtain brain MRI images and then obtain the three-dimensional coordinates of the target area to be stimulated in the standard coordinate system through image registration. Construct a multi-tissue conductivity model that includes the skull, cerebrospinal fluid, and brain tissue; Based on the multi-tissue conductivity model provided by the user, the distribution of electric field intensity in the target area to be stimulated under different vibration module configurations is calculated, and the distribution position of the vibration intervention unit is determined according to the electric field intensity distribution.

4. The method for modulating brain vibration stimulation signals according to claim 3, characterized in that, The control of each vibration intervention unit outputs a vibration signal based on the corresponding vibration parameters, and generates a brain vibration stimulation signal through the interference and coordination of the vibration signals. Each vibration intervention unit is controlled to output a first vibration signal and a second vibration signal based on the corresponding vibration parameters. An envelope signal is generated by the interference superposition of the first vibration signal and the second vibration signal.

5. The method for modulating brain vibration stimulation signals according to claim 4, characterized in that, The signal frequency parameters, amplitude parameters, and duty cycle of each vibration intervention unit; When the first vibration signal and the second vibration signal interfere and superimpose to generate an envelope signal, the expression for interference superposition is: f2 = f1 + Δf; Where f1 and f2 are the frequency parameters of the first vibration signal and the second vibration signal, respectively, and A1 and A2 are the amplitude parameters of the first vibration signal and the second vibration signal, respectively. Δf is a rectangular pulse function used to control the range of stimulus duty cycle, where Δf is the frequency difference, and the value of the frequency difference ranges from 0 to 100 Hz.

6. The method for modulating brain vibration stimulation signals according to any one of claims 1-5, characterized in that, The vibration intervention unit intervenes at the left and right temporal regions or the left and right frontal poles.

7. A brain vibration stimulation signal modulation system, characterized in that, include: The demand acquisition module is used to acquire the intervention demand for brain vibration stimulation and determine the vibration stimulation signal type based on the intervention demand. The signal construction module is used to determine the distribution location of the vibration intervention units required to generate the target vibration stimulation signal type and the vibration parameters of each vibration intervention unit based on the vibration stimulation signal type. The signal generation module is used to control each of the vibration intervention units to output vibration signals based on the corresponding vibration parameters, and to generate brain vibration stimulation signals through the interference and coordination of the vibration signals.

8. A brain vibration stimulation signal modulation device, characterized in that, The brain vibration stimulation signal modulation device includes: a memory and at least one processor, wherein the memory stores instructions; The at least one processor invokes the instructions in the memory to cause the brain vibration stimulation signal modulation device to perform the steps of the brain vibration stimulation signal modulation method as described in any one of claims 1-6.

9. A computer-readable storage medium storing a computer program / instructions thereon, characterized in that, When the program / instruction is executed by the processor, it implements the steps of the brain vibration stimulation signal modulation method as described in any one of claims 1-6.

10. A computer program product comprising a computer program / instructions, characterized in that, When the computer program / instructions are executed by the processor, the steps of the brain vibration stimulation signal modulation method as described in any one of claims 1-6 are implemented.

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