Oil control composition for regulating sebaceous gland as well as preparation method and application of oil control composition

Abstract

The invention discloses an oil control composition for regulating sebaceous glands and a preparation method and application thereof, and belongs to the technical field of cosmetics, the oil control composition for regulating sebaceous glands comprises the following components in parts by mass: 0.5-10 parts of 10-hydroxydecanoic acid, 5-25 parts of sarcosine and 5-50 parts of an oil control agent, the oil control agent comprises a Thermus thermophilus fermentation product, the mass percentage content of the Thermus thermophilus fermentation product in the oil control agent is not less than 80%; the 10-hydroxydecanoic acid, the sarcosine and the oil control agent are combined according to the specific mass parts to obtain the composition with an excellent oil control effect, and the composition can effectively inhibit 5 alpha-reductase in sebaceous gland cells, reduce conversion of testosterone to dihydrotestosterone (DHT), inhibit sebaceous gland secretion and reduce grease accumulation on the skin surface, so that the sebaceous gland skin-care effect is improved, and the skin-care effect is improved. Pore blockage is reduced, the number of active sebaceous gland bodies is reduced, the secretion activity of the active sebaceous gland bodies is reduced, and skin grease is effectively reduced.

Description

Technical Field

[0001] This application relates to the field of cosmetic technology, specifically to an oil-controlling composition for regulating sebaceous glands, its preparation method, and its application. Background Technology

[0002] Oily skin is a common skin type characterized by excessive sebum secretion from the sebaceous glands. Excessive sebum production leads to shiny, rough skin on the face and other parts of the body, enlarged pores, and a tendency to develop skin problems such as blackheads, acne, and pimples. The development of oily skin is related to multiple factors, including genetics, environmental pollution, improper diet, and hormonal imbalances.

[0003] Traditional oil-control techniques often rely on the physical adsorption of single ingredients, such as mineral adsorbents like kaolin and bentonite, or achieve a temporary astringent effect through alcohol evaporation. However, these methods have the following drawbacks: 1. Adsorbents easily clog pores, leading to skin barrier damage with long-term use; 2. Alcohol disrupts the skin's hydrolipidic film, causing dryness and flaking; 3. They lack fundamental regulation of sebaceous gland secretion, making the oil-control effect difficult to sustain; 4. Single ingredients cannot address the complex problems associated with oily skin, such as the proliferation of Propionibacterium acnes and Malassezia infection.

[0004] Therefore, this application is submitted. Summary of the Invention

[0005] The purpose of this application is to overcome the shortcomings of the existing technology and provide an oil-controlling composition for regulating sebaceous glands, its preparation method and application, wherein the composition has excellent oil-controlling and anti-inflammatory effects.

[0006] To achieve the above objectives, the first aspect of this application provides an oil-controlling composition for regulating sebaceous glands, comprising the following components in parts by weight: 0.5 to 10 parts of 10-hydroxydecanoic acid, 5 to 25 parts of sarcosine, and 5 to 50 parts of an oil-controlling agent;

[0007] The oil-controlling agent contains at least 80% by mass of thermophilic bacteria fermentation products.

[0008] As an embodiment of this application, it includes the following components in parts by weight: 1 to 6 parts of 10-hydroxydecanoic acid, 8 to 20 parts of sarcosine and 8 to 30 parts of oil-controlling agent.

[0009] As an embodiment of this application, it includes the following components in parts by weight: 2-3 parts of 10-hydroxydecanoic acid, 12-18 parts of sarcosine and 12-20 parts of oil-controlling agent.

[0010] As an embodiment of this application, the 10-hydroxydecanoic acid in the oil-controlling composition for regulating sebaceous glands has a mass percentage content of not less than 4%.

[0011] As an embodiment of this application, the 10-hydroxydecanoic acid in the oil-controlling composition for regulating sebaceous glands has a mass percentage content of 4-12%.

[0012] As an embodiment of this application, the oil-controlling agent has a mass percentage content of no more than 60% in the oil-controlling composition for regulating sebaceous glands.

[0013] As an embodiment of this application, the oil-controlling agent has a mass percentage content of 47-59% in the oil-controlling composition for regulating sebaceous glands.

[0014] As an embodiment of this application, the creatine content in the oil-controlling composition for regulating sebaceous glands is 29-48% by mass.

[0015] As an embodiment of this application, the mass percentage of thermophilic bacteria fermentation product in the oil-controlling agent is 80-100%, preferably 80-96%.

[0016] As an embodiment of this application, the oil-controlling agent comprises the following components in weight percentage: 80-96% thermophilic bacteria fermentation product, 2-10% 1,2-hexanediol, and 2-10% glycerol.

[0017] The second aspect of this application provides the use of an oil-controlling composition that regulates sebaceous glands in the preparation of cosmetics.

[0018] As an embodiment of this application, the dosage form of the cosmetic is an aqueous solution, emulsion, cream, gel, or mask.

[0019] As an embodiment of this application, the oil-controlling composition for regulating sebaceous glands has a mass percentage content of 0.01-10% in cosmetics.

[0020] As an embodiment of this application, the oil-controlling composition for regulating sebaceous glands has a mass percentage content of 0.1% to 2% in cosmetics.

[0021] A third aspect of this application provides an essence lotion comprising the following components in parts by weight: 0.01 to 10 parts of an oil-controlling composition for regulating sebaceous glands, 0.01 to 0.1 parts of a chelating agent, 0.5 to 2 parts of a thickener, 2 to 10 parts of a moisturizer, 0.2 to 2 parts of a surfactant, 0.2 to 1 part of a penetration enhancer, and 70 to 90 parts of water; wherein the oil-controlling composition for regulating sebaceous glands comprises the oil-controlling composition for regulating sebaceous glands described above.

[0022] As an embodiment of this application, the essence lotion comprises the following components in parts by weight: 0.01 to 10 parts of an oil-controlling composition for regulating sebaceous glands, 0.01 to 0.1 parts of disodium EDTA, 0.5 to 2 parts of ammonium acryloyldimethyl taurate / VP copolymer, 4 to 8 parts of 1,3-propanediol, 0.5 to 2 parts of 1,2-hexanediol, 0.05 to 0.5 parts of ethylhexylglycerin, 0.5 to 4 parts of polydimethylsiloxane, 0.5 to 2 parts of panthenol, 0.5 to 2 parts of glyceryl glucoside, 0.2 to 2 parts of PEG / PPG-14 / 7 dimethyl ether, 0.2 to 1 part of isosorbide dimethyl ether, and 70 to 90 parts of water.

[0023] The beneficial effects of this application are as follows: This application combines 10-hydroxydecanoic acid, sarcosine, and an oil-controlling agent according to the specific mass proportions mentioned above, resulting in a composition with excellent oil-controlling and anti-inflammatory effects. The inventors speculate that the 10-hydroxydecanoic acid, sarcosine, and oil-controlling agent may interact through different mechanisms. Both 10-hydroxydecanoic acid and thermophilic bacteria fermentation products have excellent penetration-enhancing effects, effectively improving the penetration of other components, promoting skin absorption, and increasing raw material utilization. Sarcosine can improve the compatibility between formulations, effectively unclog keratinocytes, and tighten the skin, thus providing a better environment for the production of 10-hydroxydecanoic acid, sarcosine, and oil-controlling agents. The role of thermophilic bacteria fermentation products provides a basis, and the 10-hydroxydecanoic acid, sarcosine, and thermophilic bacteria fermentation products all have certain anti-inflammatory and antioxidant effects, which can reduce the production of inflammation and effectively inhibit the growth of Propionibacterium acnes, thereby effectively inhibiting 5α-reductase in sebaceous gland cells, reducing the conversion of testosterone to dihydrotestosterone (DHT), inhibiting sebaceous gland secretion, reducing the accumulation of oil on the skin surface, reducing pore blockage, reducing the number of active sebaceous glands and reducing their secretory activity, thus controlling oil secretion from the root cause, and effectively activating the AMPK oil-controlling pathway to effectively reduce skin oil. Attached Figure Description

[0024] Figure 1 The image shows the actual product of the essence lotion prepared in Example 3. Detailed Implementation

[0025] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions in the embodiments of this application will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of this application, not all embodiments. Based on the embodiments in this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0026] In this application, the technical features described in an open-ended manner include both closed technical solutions consisting of the listed features and open technical solutions that include the listed features.

[0027] In this application, numerical ranges are referred to as continuous unless otherwise specified, and include the minimum and maximum values ​​of the range, as well as every value between the minimum and maximum values. Furthermore, when the range refers to integers, it includes every integer between the minimum and maximum values ​​of the range. Additionally, when multiple ranges are provided to describe a feature or characteristic, the ranges may be merged. In other words, unless otherwise specified, all ranges disclosed herein should be understood to include any and all subranges to which they are incorporated.

[0028] In this application, there are no particular restrictions on the specific dispersion and mixing methods.

[0029] Unless otherwise specified, all components, raw materials, or instruments used in the embodiments and comparative examples of this application are commercially available, and the components and raw materials used in each parallel experiment are the same.

[0030] Among them, 10-hydroxydecanoic acid-1 is derived from Shenzhen Zhongke Xinyang Biotechnology Co., Ltd.

[0031] 10-Hydroxydecanoic acid-2: Derived from Dongfang Miaosen Biotechnology, brand name SebumBate.

[0032] Creatine-1: Sourced from Shenzhen Zhongke Xinyang Biotechnology Co., Ltd.

[0033] Creatine-2: Derived from BASF, brand name SCALPOSINE BC 10101.

[0034] Thermophilic bacteria fermentation product: derived from InnoFermeLIVE-TTF2-SCP, brand name InnoFermeLIVE-TTF2-SCP.

[0035] Ectoin: Sourced from Guangzhou Wanlu Biotechnology, brand name RonaCare Ectoin.

[0036] North American witch hazel water: sourced from Hefei Snout Biotechnology Co., Ltd.

[0037] Hydroxyapatite: sourced from Guangzhou Landai Biotechnology Co., Ltd., brand name Delacare Reco.

[0038] Inositol: Sourced from Guangzhou Yixin Technology.

[0039] All other raw materials are commercially available cosmetic grade.

[0040] This application provides an oil-controlling composition for regulating sebaceous glands, comprising the following components in parts by weight: 0.5-10 parts of 10-hydroxydecanoic acid, 5-25 parts of sarcosine, and 5-50 parts of oil-controlling agent;

[0041] The oil-controlling agent contains at least 80% by mass of thermophilic bacteria fermentation products.

[0042] Among them, sarcosine (listed in the 2021 edition of the Cosmetic Ingredient Catalogue, serial number 03143) can inhibit 5α-reductase in sebaceous gland cells, reducing the conversion of testosterone to dihydrotestosterone (DHT). DHT is a key hormone that stimulates sebaceous glands to secrete oil; by inhibiting its production, sarcosine can effectively reduce sebum secretion. Simultaneously, sarcosine can regulate the skin's water-oil balance, and by improving the skin's moisturizing ability, it can reduce excessive oil secretion caused by dehydration, keeping the skin fresh and non-greasy.

[0043] 10-Hydroxydecanoic acid (listed in the 2021 edition of the Cosmetic Raw Material Catalog, serial number 00014, 10-HDA) is a naturally occurring fatty acid, primarily derived from royal jelly secreted by bees. Royal jelly is a nutrient solution secreted by bees to feed queen bee larvae, containing rich nutrients including proteins, fatty acids, vitamins, and minerals. 10-Hydroxydecanoic acid possesses excellent anti-inflammatory effects, effectively reducing skin inflammation and decreasing the release of pro-inflammatory factors such as TNF-α and IL-6. It also exhibits excellent moisturizing effects, effectively preventing skin moisture loss, increasing skin hydration, effectively inhibiting sebaceous gland secretion, reducing oil accumulation on the skin surface, reducing pore blockage, decreasing the number of active sebaceous glands and their secretory activity, and effectively inhibiting the activity of 5α-reductase, thus controlling oil secretion at its source. Furthermore, it has specific antibacterial effects, effectively inhibiting the growth of Propionibacterium acnes, disrupting its biofilm structure, effectively preventing and alleviating acne, and balancing skin oil and water levels.

[0044] Among them, thermophilic thermophilic bacteria fermentation products (catalog of used cosmetic raw materials 2021 edition, serial number 06177) are products produced by thermophilic bacteria (such as thermophilic bacteria and acidophilic bacteria) growing in high-temperature environments through fermentation. They contain enzymes, organic acids, polysaccharides, and peptides as active ingredients. They have a significant inhibitory effect on 5α-reductase and can effectively activate the AMPK oil-controlling pathway. After activation, AMPK phosphorylates and inhibits acetyl-CoA carboxylase (ACC), which is the rate-limiting enzyme in fatty acid synthesis (catalyzing the conversion of acetyl-CoA to malonyl-CoA). Decreased ACC activity directly reduces fatty acid production. Simultaneously, AMPK can inhibit hydroxymethyl... Glutamic acid-CoA reductase (HMGCR) is a key rate-limiting enzyme in cholesterol synthesis. Inhibition of its activity reduces cholesterol synthesis, thereby effectively lowering lipid levels by reducing fatty acids and hydroxymethylglutaryl-CoA reductase. AMPK also indirectly inhibits the expression of lipid synthesis genes by affecting transcription factors: inhibiting sterol regulatory element-binding proteins (SREBPs). AMPK activation prevents SREBPs from entering the cell nucleus, thus preventing them from initiating the transcription of downstream lipid synthesis genes. Furthermore, the fermentation products of Thermophilic bacteria contain various antibacterial and anti-inflammatory components, which can effectively reduce skin inflammation caused by excessive sebum secretion and effectively repair the skin barrier.

[0045] This application creatively combines 10-hydroxydecanoic acid, sarcosine, and an oil-controlling agent in the aforementioned specific mass proportions to obtain a composition with excellent oil-controlling effects. Furthermore, the inventors have discovered that 10-hydroxydecanoic acid, sarcosine, and the oil-controlling agent also possess excellent anti-inflammatory effects. The applicant speculates that this may be due to the interaction of the 10-hydroxydecanoic acid, sarcosine, and thermophilic bacteria fermentation product through different mechanisms. Both 10-hydroxydecanoic acid and the thermophilic bacteria fermentation product have excellent penetration-enhancing effects, effectively improving the penetration of other components, promoting skin absorption, and increasing raw material utilization. Sarcosine can improve the compatibility of the formulation, effectively unclog keratinocytes, and tighten the skin, providing a basis for the effects of 10-hydroxydecanoic acid and the thermophilic bacteria fermentation product. Moreover, the 10-hydroxydecanoic acid... The acid, sarcosine, and thermophilic bacteria fermentation products all have certain anti-inflammatory and antioxidant effects, which can reduce the production of inflammation and effectively inhibit the growth of Propionibacterium acnes. This effectively inhibits 5α-reductase in sebaceous gland cells, reduces the conversion of testosterone to dihydrotestosterone (DHT), inhibits sebaceous gland secretion, reduces the accumulation of oil on the skin surface, reduces pore blockage, reduces the number of active sebaceous glands and reduces their secretory activity, thus controlling oil secretion from the root. At the same time, it effectively activates the AMPK oil-controlling pathway and effectively reduces skin oil. Based on the complex mechanism of action of 10-hydroxydecanoic acid, sarcosine, and thermophilic bacteria fermentation products, the selection and ratio of the three components also have high specificity. If the types in the composition are replaced or the ratio of the three components is changed, the oil-controlling and anti-inflammatory effects will be significantly reduced.

[0046] The amount of 10-hydroxydecanoic acid used is 0.5 to 10 parts, for example, it can be 0.5 parts, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts or any two of these values.

[0047] The amount of creatine used is 5 to 25 parts, for example, it can be 5 parts, 6 parts, 8 parts, 10 parts, 12 parts, 14 parts, 15 parts, 16 parts, 18 parts, 20 parts, 22 parts, 24 parts, 25 parts or any two of these values.

[0048] The amount of the oil-controlling agent is 5 to 50 parts, for example, it can be 5 parts, 6 parts, 8 parts, 10 parts, 12 parts, 14 parts, 15 parts, 16 parts, 18 parts, 20 parts, 22 parts, 24 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts, 50 parts, or any two of these values.

[0049] In one embodiment, the components include the following parts by weight: 1 to 6 parts of 10-hydroxydecanoic acid, 8 to 20 parts of sarcosine and 8 to 30 parts of oil-controlling agent. In particular, when the amount of each raw material is controlled within this range, the compatibility between the raw materials is better, and there is a better synergistic effect. It can further inhibit the secretion of skin oil and inhibit 5α-reductase in sebaceous gland cells, thereby further improving the oil-controlling effect.

[0050] In one embodiment, the components include the following parts by weight: 2 to 3 parts of 10-hydroxydecanoic acid, 12 to 18 parts of sarcosine and 12 to 20 parts of oil-controlling agent. In particular, when the amount of each raw material is within this range, it has the best synergistic effect and further improves the oil-controlling effect.

[0051] In one embodiment, the 10-hydroxydecanoic acid is present in a mass percentage of not less than 4% in the oil-controlling composition for regulating sebaceous glands.

[0052] In one embodiment, the mass percentage of 10-hydroxydecanoic acid in the sebaceous gland-regulating oil-controlling composition is 4-12%, for example, it can be 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, or any two of these values. By controlling the mass percentage of 10-hydroxydecanoic acid in the sebaceous gland-regulating oil-controlling composition within this range, the content of creatine is not too low, ensuring the inhibitory effect on dihydrotestosterone, effectively reducing the conversion of testosterone to dihydrotestosterone, reducing the secretion of sebum, and ensuring that the skin has a good astringent effect, effectively unclogging the stratum corneum, which is more conducive to the oil-controlling effect of 10-hydroxydecanoic acid and thermophilic bacteria fermentation products.

[0053] In one embodiment, the oil-controlling agent has a mass percentage content of no more than 60% in the oil-controlling composition for regulating sebaceous glands.

[0054] In one embodiment, the oil-controlling agent has a mass percentage content of 47-59% in the oil-controlling composition for regulating sebaceous glands. For example, it can be a range of 47%, 48%, 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or any two of these values. By controlling the mass percentage content of the thermophilic bacteria fermentation product in the oil-controlling composition within this range, the activation effect on the AMPK oil-controlling pathway and the inhibition effect on 5α-reductase can be guaranteed, promoting the penetration and absorption of each component, reducing skin inflammation caused by excessive sebum secretion, effectively repairing the skin barrier, and further improving the oil-controlling effect.

[0055] In one embodiment, the mass ratio of creatine to the oil-controlling agent is 1:(1-1.4), for example, it can be 1:1, 1:1.1, 1:1.2, 1:1.3, 1:1.4 or any two of these values. By controlling the mass ratio of creatine to the oil-controlling agent within this range, the inhibitory effect of testosterone to dihydrotestosterone conversion and the activation effect of the AMPK oil-controlling pathway can be balanced, and the inhibitory effect on 5α-reductase can be improved, so that the composition can exert a more ideal synergistic effect and further improve the oil-controlling effect.

[0056] In one embodiment, the creatine content in the sebaceous gland-regulating oil-controlling composition is 29% to 48% by mass, for example, it can be 29%, 30%, 31%, 32%, 35%, 36%, 38%, 40%, 42%, 45%, 48%, or any two of these values.

[0057] The oil-controlling agent contains 80-100% by mass of thermophilic bacteria fermentation products, preferably 80-96%.

[0058] In one embodiment, the oil-controlling agent contains 80-96% by mass of thermophilic bacteria fermentation products.

[0059] In one embodiment, the oil-controlling agent contains 90-94% by mass of thermophilic bacteria fermentation products.

[0060] In one embodiment, the oil-controlling agent comprises the following components by weight percentage: 80-96% *Thermophilicus thermophilus* fermentation product, 2-10% 1,2-hexanediol, and 2-10% glycerin. The oil-controlling agent, composed of *Thermophilicus thermophilus* fermentation product, 1,2-hexanediol, and glycerin in a specific ratio, utilizes 1,2-hexanediol to help dissolve oil, and glycerin's moisturizing effect to help the skin maintain proper hydration. The combination of these three components effectively reduces oil accumulation and secretion on the skin surface, maintains the skin's water-oil balance, and prevents dryness or oiliness. Furthermore, the addition of 1,2-hexanediol and glycerin provides a good foundation for the effects of *Thermophilicus thermophilus* fermentation product, 10-hydroxydecanoic acid, and sarcosine, thereby further enhancing the oil-controlling effect.

[0061] In one embodiment, the oil-controlling agent comprises the following components by weight percentage: 90-94% thermophilic bacteria fermentation product, 3-5% 1,2-hexanediol, and 3-5% glycerol.

[0062] In one embodiment, the oil-controlling composition for regulating sebaceous glands may also contain cosmetically acceptable excipients.

[0063] In one embodiment, the cosmetic excipients include, but are not limited to, at least one of solvents, thickeners, moisturizers, emollients, emulsifiers, preservatives, antioxidants, pH adjusters, penetration enhancers, chelating agents, surfactants, fragrances, and pigments.

[0064] In one embodiment, the oil-controlling composition for regulating sebaceous glands may include a solvent, and suitable solvents include, but are not limited to, at least one of butylene glycol, 1,3-propanediol, dipropylene glycol, and deionized water.

[0065] In one embodiment, the oil-controlling composition for regulating sebaceous glands may include a thickener, and suitable thickeners include, but are not limited to, xanthan gum, strychnine gum, Carrageenan extract, Sphingomonas fermentation product extract, hydroxyethyl cellulose, carbomer, acrylate / C10-30 alkanol acrylate crosspolymer, ammonium acryloyl dimethyl taurate / VP copolymer, and polyacrylate crosspolymer-6.

[0066] In one embodiment, the oil-controlling composition for regulating sebaceous glands may include a moisturizer, and suitable moisturizers include, but are not limited to, at least one of sodium hyaluronate, panthenol, hydroxyethyl urea, polyethylene glycol, xylitol, maltose, sodium polyglutamate, erythritol, sorbitol, mannitol, glucose, lactose, betaine, inositol, trehalose, and hydrogenated starch hydrolysate.

[0067] In one embodiment, the oil-controlling composition for regulating sebaceous glands may include an emollient, suitable emollients including but not limited to at least one of isododecane, isohexadecane, caprylic / capric triglyceride, pentaerythritol tetraisostearate, polydimethylsiloxane, isononyl isononanoate, diisostearate malate, phytosterol malate oleate, squalane, hexyl laurate, castor oil, hydrogenated polyisobutylene, octyl dodecyl alcohol, shea butter, dioctyl carbonate, jojoba oil, lanolin, sweet almond oil, dioctyl adipate, and cocoyl caprylate / capric ester.

[0068] In one embodiment, the oil-controlling composition for regulating sebaceous glands may include an emulsifier, suitable emulsifiers including but not limited to at least one of glyceryl stearate, polyglycerol-10 stearate, polyglycerol-10 laurate, polyglycerol-10 myristate, polyglycerol-5 trioleate, PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PPG-13-decyltetradecyl alcohol polyether-24, sodium stearoyl glutamate, stearyl alcohol polyether-2, stearyl alcohol polyether-21, and hydrogenated lecithin.

[0069] In one embodiment, the oil-controlling composition for regulating sebaceous glands may include an antioxidant, and suitable antioxidants include, but are not limited to, at least one of ascorbic acid and its derivatives, resveratrol, pentaerythritol tetra(bis-tert-butylhydroxyhydrocinnamic acid) ester, arbutin, tocopherol (vitamin E), and sodium metabisulfite.

[0070] In one embodiment, the oil-controlling composition for regulating sebaceous glands may include a pH adjuster, and suitable pH adjusters include, but are not limited to, at least one of arginine, tromethamine, aminomethylpropanol, tetrahydroxypropyl ethylenediamine, triethanolamine, citric acid, sodium citrate, sodium hydroxide, and potassium hydroxide.

[0071] In one embodiment, the oil-controlling composition for regulating sebaceous glands may include a colorant, and suitable colorants include, but are not limited to, at least one of the following colors: white, black, yellow, blue, green, pink, red, orange, purple, indigo, and brown.

[0072] In one embodiment, the oil-controlling composition for regulating sebaceous glands may include a preservative, suitable preservatives including but not limited to at least one of p-hydroxyacetophenone, 1,2-hexanediol, 1,2-pentanediol, isopentanediol, ethylhexylglycerin, caprylyl glycol, chlorphenesin, methylparaben, potassium sorbate, sodium benzoate, phenoxyethanol, caprylyl hydroxamic acid, and glyceryl caprylate.

[0073] One embodiment of this application provides the application of an oil-controlling composition that regulates sebaceous glands in the preparation of cosmetics.

[0074] In one embodiment, the cosmetic product is in the form of an aqueous solution, lotion, cream, gel, or mask.

[0075] In one embodiment, the oil-controlling composition for regulating sebaceous glands has a mass percentage of 0.01 to 10% in the cosmetic, for example, 0.01%, 0.05%, 0.1%, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, or 10%.

[0076] In one embodiment, the oil-controlling composition for regulating sebaceous glands has a mass percentage of 0.1% to 2% in the cosmetic.

[0077] One embodiment of this application provides an essence lotion comprising the following components in parts by weight: 0.01 to 10 parts of an oil-controlling composition for regulating sebaceous glands, 0.01 to 0.1 parts of a chelating agent, 0.5 to 2 parts of a thickener, 6.05 to 16.5 parts of a moisturizer, 0.2 to 2 parts of a surfactant, 0.2 to 1 part of a penetration enhancer, and 70 to 90 parts of water, wherein the oil-controlling composition for regulating sebaceous glands includes the oil-controlling composition for regulating sebaceous glands described above.

[0078] In one embodiment, the chelating agent in the essence emulsion includes at least one of disodium EDTA and tetrasodium EDTA.

[0079] In one embodiment, the thickener in the essence emulsion includes at least one of xanthan gum, strychnine gum, chondrus crispus extract, Sphingomonas fermentation product extract, hydroxyethyl cellulose, carbomer, acrylate / C10-30 alkanol acrylate crosspolymer, ammonium acryloyl dimethyl taurate / VP copolymer, and polyacrylate crosspolymer-6.

[0080] In one embodiment, the moisturizer in the essence lotion includes at least one of butylene glycol, 1,3-propanediol, dipropylene glycol, glycerin, 1,2-hexanediol, sodium hyaluronate, panthenol, ethylhexylglycerin, dimethicone, hydroxyethyl urea, polyethylene glycol, xylitol, maltose, sodium polyglutamate, erythritol, sorbitol, mannitol, glucose, lactose, betaine, inositol, trehalose, hydrogenated starch hydrolysate, and glyceryl glucoside.

[0081] In one embodiment, the surfactant in the essence lotion includes at least one of sodium C14-16 olefin sulfonate, sodium lauryl ether sulfate, sodium lauryl sulfate, cocamidopropyl betaine, lauryl hydroxysulfonyl betaine, octyl / decyl glucoside, decyl glucoside, cocoyl glucoside, and PEG / PPG-14 / 7 dimethyl ether.

[0082] In one embodiment, the penetration enhancer in the essence lotion includes at least one of isosorbide dimethyl ether, menthol, menthol, peppermint oil, azone, and oleic acid.

[0083] In one embodiment, the composition comprises the following components in parts by weight: 0.01 to 10 parts of oil-controlling composition, 0.01 to 0.1 parts of disodium EDTA, 0.5 to 2 parts of ammonium acryloyldimethyl taurate / VP copolymer, 4 to 8 parts of 1,3-propanediol, 0.5 to 2 parts of 1,2-hexanediol, 0.05 to 0.5 parts of ethylhexylglycerin, 0.5 to 4 parts of polydimethylsiloxane, 0.5 to 2 parts of panthenol, 0.5 to 2 parts of glyceryl glucoside, 0.2 to 2 parts of PEG / PPG-14 / 7 dimethyl ether, 0.2 to 1 part of isosorbide dimethyl ether, and 70 to 90 parts of water.

[0084] The following embodiments are provided to facilitate understanding of this application. These embodiments are provided not to limit the scope of the claims.

[0085] Examples 1-18

[0086] The formulations of the oil-controlling compositions for regulating sebaceous glands in Examples 1 to 18 of the present invention are shown in Table 1.

[0087] In Examples 1-6, the amount of each of the three raw materials was changed individually.

[0088] In Examples 3 and 7-9, the mass ratio of sarcosine and oil-controlling agent (the total amount of sarcosine and oil-controlling agent is the same in the oil-controlling composition) was changed individually.

[0089] The difference between Examples 10-13 and Example 3 is that the mass fraction of each raw material is within the range of this application (the total mass is the same as in Example 3). By adjusting the amount of each raw material, the proportion of it in the composition is adjusted (i.e., the mass percentage content deviates from the ideal range).

[0090] Example 14: The sources of 10-hydroxydecanoic acid and sarcosine were changed (10-hydroxydecanoic acid-1 was replaced with an equal amount of 10-hydroxydecanoic acid-2, and sarcosine-1 was replaced with an equal amount of sarcosine-2).

[0091] Examples 15-19 show variations in the composition of the oil-controlling agent, as detailed in Table 1.

[0092] The preparation method of the oil-controlling composition for regulating sebaceous glands in Examples 1-14 is as follows: Thermophilic bacteria fermentation product, 10-hydroxydecanoic acid and sarcosine are mixed evenly to obtain the oil-controlling composition.

[0093] The preparation method of the oil-controlling composition for regulating sebaceous glands in Examples 15-18 is as follows: Thermophilic bacteria fermentation product, 1,2-hexanediol and glycerol are first mixed evenly to obtain an oil-controlling agent, and then mixed evenly with 10-hydroxydecanoic acid and sarcosine to obtain an oil-controlling composition.

[0094] Table 1

[0095]

[0096] Comparative Examples 1-13

[0097] Thirteen comparative examples of the oil-controlling composition for regulating sebaceous glands described in this invention are provided, with the formulations of Comparative Examples 1-5 and 9-13 shown in Table 2 below. The mass fractions of Comparative Examples 1-2 are not within the scope of this application. Comparative Examples 3-5 differ from Example 3 in that they lack one component in their composition. Comparative Examples 9-12 use other components to replace one component in their composition, and Comparative Example 13 adjusts the component ratio of the oil-controlling agent.

[0098] Comparative Example 6 is a single 10-hydroxydecanoic acid.

[0099] Comparative Example 7 was a single creatine.

[0100] Comparative Example 8 was a fermentation product of a single thermophilic bacterium.

[0101] Table 2

[0102]

[0103]

[0104] Test case

[0105] I. 5α-reductase inhibition rate test

[0106] 1. Experimental Principle and Method

[0107] 1.1 Experimental Materials and Instruments

[0108] 1) Experimental materials: 5α-reductase preparation solution (extracted from the liver of male mice, protein concentration 0.08 mg / mL, Guangzhou Analysis and Testing Center, China), BCA protein concentration assay kit (Beyotime), testosterone (Sinopharm Chemical Reagent Co., Ltd.), reduced coenzyme II NADPH (Beijing Bailingwei Technology Development Co., Ltd.), anhydrous ethanol (Tianjin Kangkede Technology Co., Ltd.), sucrose (Zhejiang Tianyi Food Additives Co., Ltd.), dutasteride (DTS) (Tianjin Kangkede Technology Co., Ltd.), sodium nitrate (Sinopharm Chemical Reagent Co., Ltd.).

[0109] 2) Experimental instruments: microplate reader (Perkinelmer, Singapore, EnSight), mixer (SCILOGEX, USA, MX-S), water bath (Thermo Fisher Scientific, GP10), analytical balance (Sartorius, MCA224S-2CCN-I-QP99).

[0110] 1.2 Experimental Principle

[0111] 5α-Reductase catalyzes the conversion of testosterone to dihydrotestosterone, a process that requires the coenzyme NADPH. Reduced NADPH exhibits a characteristic absorption at 340 nm, and as the reaction proceeds, NADPH is converted to oxidized NADP. + The characteristic absorption at 340 nm will then disappear. The change in NADPH absorbance in the reaction system at 340 nm reflects the change in 5α-reductase activity. Inhibiting 5α-reductase to reduce dihydrotestosterone levels is an important way to alleviate excessive sebum secretion. This experiment evaluates the oil-controlling efficacy of the samples by testing their effect on 5α-reductase.

[0112] 1.3 Reaction System

[0113] 1) The reaction system is shown in Table 3.

[0114] Table 3

[0115]

[0116] 2) Blank control assay: Following the above reaction system, add 12 μL of 0.08 mg / mL liver homogenate, 108 μL of enzyme diluent, 60 μL of 2 mg / mL NADPH tetrasodium salt, 10 μL of 1 mg / mL testosterone, and 10 μL of phosphate buffer (pH 7.2 ± 0.2) to each well of a 96-well plate. After thorough mixing, measure the absorbance A0. Incubate at 37℃ for 20 min, then measure the absorbance A1. Obtain the NADPH absorbance change value ΔA0.

[0117] 3) Sample / Positive Group (0.5 mg / mL DTS) Determination: The sample (products from the above examples and comparative examples) was prepared into a 1 mg / mL test solution. Liver tissue homogenate, enzyme diluent, test solution, testosterone, and NADPH were added sequentially to a 96-well plate according to the above reaction system. After thorough mixing, the absorbance An was measured. After incubation at 37°C for 20 min, the absorbance was measured again, and the change in NADPH ΔAn was determined.

[0118] 4) The 5α-reductase inhibition rate was calculated as follows:

[0119] △A0=(A0-A1) / A0

[0120] △An=(A0-An) / A0

[0121] 5α-reductase inhibition rate (%) = [(△A0-△An) / △A0]*100%.

[0122] 5) The test results are shown in Table 4.

[0123] II. Volunteer Test

[0124] 1.1 155 volunteers were selected and randomly divided into 31 groups (31*5). The serums prepared using the compositions described in Examples 1-18 and Comparative Examples 1-13 were tested respectively. The specific preparation methods are as follows:

[0125] The sebaceous gland regulating compositions of Examples 1-18, Comparative Examples 1-5, and Comparative Examples 9-13 were all prepared into serums according to the following formulation ratios and methods: The serums comprised the following components in parts by weight: 0.5 parts of the sebaceous gland regulating oil-controlling composition, 0.05 parts of disodium EDTA, 1 part of ammonium acryloyl dimethyl taurate / VP copolymer, 5 parts of 1,3-propanediol, 1.5 parts of 1,2-hexanediol, 0.1 parts of ethylhexylglycerin, 2 parts of polydimethylsiloxane, 1 part of panthenol, 1 part of glyceryl glucoside, 0.5 parts of PEG / PPG-14 / 7 dimethyl ether, 0.5 parts of isosorbide dimethyl ether, and 87.82 parts of water.

[0126] The preparation methods of the serums in Examples 1-18, Comparative Examples 1-5, and Comparative Examples 9-13 are as follows: Disodium EDTA, ammonium acryloyl dimethyl taurate / VP copolymer, 1,3-propanediol, 1,2-hexanediol, ethylhexylglycerin, polydimethylsiloxane, panthenol, and water are stirred evenly at 200 rpm at 60°C. The mixture is then cooled to 40°C, and an oil-controlling composition for regulating sebaceous glands, glyceryl glucoside, PEG / PPG-14 / 7 dimethyl ether, and isosorbide dimethyl ether are added. The mixture is stirred evenly at 200 rpm to obtain the serum. A physical image of the serum in Example 3 is shown below. Figure 1 As shown.

[0127] Comparative Example 6 was prepared into an essence emulsion according to the following formulation and method: The essence emulsion comprises the following components in parts by weight: 0.5 parts 10-hydroxydecanoic acid-1, 0.05 parts disodium EDTA, 1 part ammonium acryloyldimethyl taurate / VP copolymer, 5 parts 1,3-propanediol, 1.5 parts 1,2-hexanediol, 0.1 parts ethylhexylglycerin, 2 parts polydimethylsiloxane, 1 part panthenol, 1 part glyceryl glucoside, 0.5 parts PEG / PPG-14 / 7 dimethyl ether, 0.5 parts isosorbide dimethyl ether, and 87.82 parts water.

[0128] The preparation method of the essence lotion described in Comparative Example 6 is as follows: Disodium EDTA, ammonium acryloyl dimethyl taurate / VP copolymer, 1,3-propanediol, 1,2-hexanediol, ethylhexylglycerin, polydimethylsiloxane, panthenol, and water are stirred evenly at 200 rpm at 60°C, cooled to 40°C, and then 10-hydroxydecanoic acid-1, glyceryl glucoside, PEG / PPG-14 / 7 dimethyl ether, and isosorbide dimethyl ether are added and stirred evenly at 200 rpm to obtain the essence lotion.

[0129] Comparative Example 7 was prepared into an essence emulsion according to the following formulation and method: The essence emulsion comprises the following components in parts by weight: 0.5 parts sarcosine-1, 0.05 parts disodium EDTA, 1 part ammonium acryloyl dimethyl taurate / VP copolymer, 5 parts 1,3-propanediol, 1.5 parts 1,2-hexanediol, 0.1 parts ethylhexylglycerin, 2 parts polydimethylsiloxane, 1 part panthenol, 1 part glyceryl glucoside, 0.5 parts PEG / PPG-14 / 7 dimethyl ether, 0.5 parts isosorbide dimethyl ether, and 87.82 parts water.

[0130] The preparation method of the essence lotion described in Comparative Example 7 is as follows: Disodium EDTA, ammonium acryloyl dimethyl taurate / VP copolymer, 1,3-propanediol, 1,2-hexanediol, ethylhexylglycerin, polydimethylsiloxane, panthenol, and water are stirred evenly at 200 rpm at 60°C, cooled to 40°C, and then sarcosine-1, glyceryl glucoside, PEG / PPG-14 / 7 dimethyl ether, and isosorbide dimethyl ether are added and stirred evenly at 200 rpm to obtain the essence lotion.

[0131] Comparative Example 8 was prepared into an essence emulsion according to the following formulation and method: The essence emulsion comprises the following components in parts by weight: 0.5 parts thermophilic bacteria fermentation product, 0.05 parts disodium EDTA, 1 part ammonium acryloyl dimethyl taurate / VP copolymer, 5 parts 1,3-propanediol, 1.5 parts 1,2-hexanediol, 0.1 parts ethylhexylglycerin, 2 parts polydimethylsiloxane, 1 part panthenol, 1 part glyceryl glucoside, 0.5 parts PEG / PPG-14 / 7 dimethyl ether, 0.5 parts isosorbide dimethyl ether, and 87.82 parts water.

[0132] The preparation method of the essence lotion described in Comparative Example 8 is as follows: Disodium EDTA, ammonium acryloyl dimethyl taurate / VP copolymer, 1,3-propanediol, 1,2-hexanediol, ethylhexylglycerin, polydimethylsiloxane, panthenol, and water are stirred evenly at 200 rpm at 60°C, cooled to 40°C, and then thermophilic bacteria fermentation product, glyceryl glucoside, PEG / PPG-14 / 7 dimethyl ether, and isosorbide dimethyl ether are added and stirred evenly at 200 rpm to obtain the essence lotion.

[0133] 1.2 Volunteer inclusion criteria: men and women aged 20-35 years with high sebum secretion who have not used hormone drugs or immunosuppressants in the past month; who have not participated in other clinical trials at the test site in the past 30 days; who can cooperate well with the trial; who can read and understand all the contents of the informed consent form, and who are willing to participate and sign the informed consent form; who agree not to use any cosmetics, drugs and health products that may affect the results during the trial, and who will maintain a light diet during the test period.

[0134] 1.3 Exclusion criteria: Individuals with open wounds or erosions; individuals with a high degree of allergy; individuals with a history of cosmetic allergies; women planning to become pregnant, pregnant, breastfeeding, or within 6 months postpartum; individuals with severe systemic diseases, immunodeficiency, or autoimmune diseases; individuals with dermatological diseases in the test area or currently receiving drug treatment; individuals with a cold, flu, or other acute illness at the start of the test that may affect the participation of the study participants; individuals who have undergone other tests on the test site in the past month; individuals deemed unsuitable for this test by the researcher.

[0135] 1.4 Criteria for Termination and Withdrawal: Failure to apply the test sample as required or failure to record follow-up information as required during the test; serious illness or serious adverse reaction during use.

[0136] 1.5 Test Method: During the test period, volunteers used the corresponding serum on their entire face after cleansing every morning and evening for 14 consecutive days. The sebum content of the volunteers' skin was tested using the Sebumeter, a skin sebum content tester manufactured by Courage+Khazaka (CK) in Germany, and the rate of decrease in skin sebum was calculated.

[0137] Skin oil reduction rate = [(S14-S0) / S0]*100%.

[0138] S14 represents the skin oil content after 14 days of use, and S0 represents the skin oil content on day 0.

[0139] 1.6 The test results are shown in Table 4.

[0140] Table 4

[0141]

[0142]

[0143] As can be seen from Table 4, the composition described in this application has excellent oil control effect.

[0144] Comparing Examples 1 and 6 with Examples 2 to 5, it can be seen that by controlling the amount of each raw material to 1 to 6 parts of 10-hydroxydecanoic acid, 8 to 20 parts of sarcosine and 8 to 30 parts of oil-controlling agent, this application can further improve the oil-controlling effect.

[0145] Comparing Examples 2 and 5 with Examples 3 and 4, it can be seen that this application can further improve the oil-controlling effect by controlling the amount of each raw material to: 2-3 parts of 10-hydroxydecanoic acid, 12-18 parts of sarcosine, and 12-20 parts of oil-controlling agent.

[0146] Comparing Examples 3 with Examples 7-9, it can be seen that by controlling the mass ratio of creatine to oil-controlling agent to 1:(1-1.4), this application can further improve the oil-controlling effect.

[0147] Comparing Example 3 with Examples 10-13, it can be seen that when the amount of each raw material is 0.5-10 parts of 10-hydroxydecanoic acid, 5-25 parts of sarcosine, and 5-50 parts of oil-controlling agent, the oil-controlling effect can be further improved by controlling the mass percentage content of sarcosine, oil-controlling agent, and 10-hydroxydecanoic acid in the composition to be 29-48%, 47-59%, and 4-12%, respectively.

[0148] Comparative Examples 15-19 show that by controlling the oil-controlling agent to include the following components by mass percentage: 80-96% thermophilic bacteria fermentation product, 2-10% 1,2-hexanediol, and 2-10% glycerol, the oil-controlling effect can be further improved.

[0149] Comparing Examples 1-6 with Comparative Examples 1-2, it can be seen that by controlling the amount of each raw material to 0.5-10 parts of 10-hydroxydecanoic acid, 5-25 parts of sarcosine and 5-50 parts of oil-controlling agent, this application can significantly improve the oil-controlling effect.

[0150] Comparing Example 3 with Comparative Examples 3-12, it can be seen that the sarcosine, thermophilic bacteria fermentation product, and 10-hydroxydecanoic acid described in this application have a significant synergistic effect in oil control. The absence of any one of them, or the substitution of any one of them with other components, will lead to a significant decrease in the oil control effect.

[0151] Comparing Examples 15-19 with Comparative Example 13, it can be seen that by controlling the mass percentage of thermophilic bacteria fermentation products in the oil-controlling agent to be no less than 80%, the oil-controlling effect is significantly improved.

[0152] III. TNF-α Inhibition Rate

[0153] To investigate the anti-inflammatory effect of the composition, the following anti-inflammatory experiments were conducted on the examples and comparative examples.

[0154] Log-phase RAW264.7 cells were seeded in 96-well plates at a cell density of 1 × 10⁻⁶ cells / well. 5 Cells / mL, 0.5mL per well. After plating, mark the top cover of the cell plate and incubate at 37℃ in a 5% CO2 incubator for 24h.

[0155] After 24 hours of cell incubation, the supernatant was aspirated, and 0.5 mL of the following samples were added: ① Blank control group: DMEM medium; ② LPS inflammation model group: LPS (1 μg / mL) + DMEM medium; ③ Positive control group: 0.001% dexamethasone + LPS (1 μg / mL) + DMEM medium; ④ Experimental group: 1% of the example or comparative composition + LPS (1 μg / mL) + DMEM medium. After 24 hours of incubation, the supernatant was pipetted into centrifuge tubes, centrifuged for 5 min, the precipitate was discarded, and the supernatant was collected. The TNF-α inflammatory factor content in the supernatant was detected using an ELISA kit. The TNF-α inhibition rate was calculated as follows: TNF-α inhibition rate % = (TNF-α amount in the model group - TNF-α amount in the experimental group) / TNF-α amount in the model group × 100%. The higher the TNF-α inhibition rate % is, the stronger the anti-inflammatory ability. The results are shown in Table 5.

[0156] Table 5

[0157]

[0158]

[0159] As can be seen from Table 5, the composition described in this application has excellent anti-inflammatory effects.

[0160] Comparing Examples 1 and 6 with Examples 2 to 5, it can be seen that by controlling the amount of each raw material to 1 to 6 parts of 10-hydroxydecanoic acid, 8 to 20 parts of sarcosine and 8 to 30 parts of oil-controlling agent, this application can further improve the anti-inflammatory effect.

[0161] Comparing Examples 2 and 5 with Examples 3 and 4, it can be seen that by controlling the amount of each raw material to 2-3 parts of 10-hydroxydecanoic acid, 12-18 parts of sarcosine, and 12-20 parts of oil-controlling agent, this application can further improve the anti-inflammatory effect.

[0162] Comparing Examples 3 with Examples 7-9, it can be seen that by controlling the mass ratio of creatine to oil-controlling agent to 1:(1-1.4), this application can further improve the anti-inflammatory effect.

[0163] Comparing Example 3 with Examples 10-13, it can be seen that when the amount of each raw material is 0.5-10 parts of 10-hydroxydecanoic acid, 5-25 parts of sarcosine, and 5-50 parts of oil-controlling agent, the anti-inflammatory effect can be further improved by controlling the mass percentage content of sarcosine, oil-controlling agent, and 10-hydroxydecanoic acid in the composition to be 29-48%, 47-59%, and 4-12%, respectively.

[0164] Comparing Examples 1-6 with Comparative Examples 1-2, it can be seen that by controlling the amount of each raw material to 0.5-10 parts of 10-hydroxydecanoic acid, 5-25 parts of sarcosine and 5-50 parts of oil-controlling agent, this application can significantly improve the anti-inflammatory effect.

[0165] Comparing Example 3 with Comparative Examples 3-12, it can be seen that the sarcosine, thermophilic bacteria fermentation product, and 10-hydroxydecanoic acid described in this application have a significant synergistic effect in oil control. The absence of any one of them, or the substitution of any one of them with other components, will lead to a significant decrease in the anti-inflammatory effect.

[0166] IV. Security Testing

[0167] Materials and methods

[0168] Test substance: The essence prepared in the examples and comparative examples.

[0169] Blank control: distilled water.

[0170] Subjects: Thirty healthy subjects aged 20-35 years with no history of skin diseases or allergies were selected to conduct human skin patch tests on the soothing lotions prepared in the examples and comparative examples. Each subject's arm was divided into 32 patch test areas (16 areas on the left arm and 16 areas on the right arm, each patch test area was 1cm*1cm in size, and each patch test area did not affect each other). Patch tests were conducted on each subject's patch test areas for the examples, comparative examples, and blank control.

[0171] Patch test method: Using qualified patch test equipment, a closed patch test method was employed. 0.020–0.025 g of the test substance was placed inside the patch tester, and the outside of the device was covered with hypoallergenic adhesive tape and applied to the subject's arm. The test substance was removed after 24 hours, and skin reactions were observed 24 hours later. The results were recorded according to the skin reaction grading standards in the "Cosmetic Safety Technical Specifications" (2015 edition). The scores are shown in Table 6, and the test results are shown in Table 7.

[0172] Table 6

[0173]

[0174] Table 7

[0175]

[0176]

[0177] As can be seen from Table 6, the oil-controlling composition described in this application has good safety and is mild and non-irritating.

[0178] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this application and are not intended to limit the scope of protection of this application. Although this application has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of this application without departing from the substance and scope of the technical solutions of this application.

Claims

1. An oil-controlling composition for regulating sebaceous glands, characterized in that, It includes the following components in parts by weight: 0.5 to 10 parts 10-hydroxydecanoic acid, 5 to 25 parts sarcosine and 5 to 50 parts oil-controlling agent; The oil-controlling agent includes thermophilic bacteria fermentation products, and the thermophilic bacteria fermentation products account for no less than 80% of the oil-controlling agent by mass.

2. The oil-controlling composition for regulating sebaceous glands according to claim 1, characterized in that, It includes the following components in parts by weight: 1-6 parts 10-hydroxydecanoic acid, 8-20 parts sarcosine and 8-30 parts oil control agent.

3. The oil-controlling composition for regulating sebaceous glands according to claim 1, characterized in that, It includes the following components in parts by weight: 2-3 parts 10-hydroxydecanoic acid, 12-18 parts sarcosine and 12-20 parts oil control agent.

4. The oil-controlling composition for regulating sebaceous glands according to claim 1, characterized in that, The 10-hydroxydecanoic acid in the oil-controlling composition for regulating sebaceous glands contains no less than 4% by mass.

5. The oil-controlling composition for regulating sebaceous glands according to claim 4, characterized in that, The 10-hydroxydecanoic acid is present in the sebaceous gland-regulating oil-controlling composition at a mass percentage of 4-12%.

6. The oil-controlling composition for regulating sebaceous glands according to claim 1, characterized in that, The oil-controlling agent has a mass percentage content of no more than 60% in the oil-controlling composition for regulating sebaceous glands.

7. The oil-controlling composition for regulating sebaceous glands according to claim 6, characterized in that, The oil-controlling agent has a mass percentage content of 47-59% in the oil-controlling composition for regulating sebaceous glands.

8. The oil-controlling composition for regulating sebaceous glands according to claim 1, characterized in that, The mass ratio of creatine to oil-controlling agent is 1:(1-1.4).

9. The oil-controlling composition for regulating sebaceous glands according to claim 1, characterized in that, The sarcosine content in the oil-controlling composition for regulating sebaceous glands is 29-48% by mass.

10. The oil-controlling composition for regulating sebaceous glands according to claim 1, characterized in that, The oil-controlling agent contains 80-100% by mass of thermophilic bacteria fermentation products, preferably 80-96%.

11. The oil-controlling composition for regulating sebaceous glands according to claim 1, characterized in that, The oil-controlling agent comprises the following components by weight percentage: 80-96% thermophilic bacteria fermentation product, 2-10% 1,2-hexanediol, and 2-10% glycerol.

12. The use of the oil-controlling composition for regulating sebaceous glands according to any one of claims 1 to 11 in the preparation of cosmetics, characterized in that, The cosmetics are available in the form of aqueous solution, lotion, cream, gel, or mask.

13. The application according to claim 12, characterized in that, The oil-controlling composition for regulating sebaceous glands has a mass percentage of 0.01-10% in the cosmetic.

14. An essence lotion, characterized in that, The composition comprises the following components in parts by weight: 0.01 to 10 parts of an oil-controlling composition for regulating sebaceous glands, 0.01 to 0.1 parts of a chelating agent, 0.5 to 2 parts of a thickener, 6.05 to 16.5 parts of a moisturizer, 0.2 to 2 parts of a surfactant, 0.2 to 1 part of a penetration enhancer, and 70 to 90 parts of water, wherein the oil-controlling composition for regulating sebaceous glands comprises the oil-controlling composition for regulating sebaceous glands as described in any one of claims 1 to 11.

15. The essence lotion according to claim 14, characterized in that, The product comprises the following components in parts by weight: 0.01–10 parts of an oil-controlling composition for regulating sebaceous glands, 0.01–0.1 parts of disodium EDTA, 0.5–2 parts of ammonium acryloyldimethyl taurate / VP copolymer, 4–8 parts of 1,3-propanediol, 0.5–2 parts of 1,2-hexanediol, 0.05–0.5 parts of ethylhexylglycerin, 0.5–4 parts of polydimethylsiloxane, 0.5–2 parts of panthenol, 0.5–2 parts of glyceryl glucoside, 0.2–2 parts of PEG / PPG-14 / 7 dimethyl ether, 0.2–1 part of isosorbide dimethyl ether, and 70–90 parts of water.

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