Low-dose liquid-free detection system, method and device
By using a low-dose liquid-free detection system, differential and derivative operations are employed to determine the current or voltage signal of the nebulizer, solving the detection problem of mesh nebulizers in low-dose vaccine nebulization, and achieving efficient use of nebulizers and ensuring vaccine activity.
Patent Information
- Application Number
- CN202511282784.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-09-09
- Publication Date
- 2025-11-14
AI Technical Summary
Existing mesh nebulizers cannot meet the nebulization requirements of low-dose vaccines. The amount of residual liquid in the nebulizer is large, making it difficult to judge the completion of nebulization by visual inspection, which affects the vaccine activity and the service life of the nebulizer.
A low-dose liquid-free detection system is adopted, including a data acquisition unit, an analysis unit, a calculation unit, and a data storage unit. It judges the changes in the current or voltage signal of the nebulizer through differential operation and derivative operation, so as to accurately judge the nebulization state with and without drug liquid, and executes system shutdown in the state of no drug liquid.
It improves the accuracy of liquid-free detection, ensures complete vaccine atomization and activity, enhances the convenience of vaccination and the lifespan of the nebulizer, and reduces overall costs.
Smart Images
Figure CN120939374A_ABST
Abstract
Description
Technical Field
[0001] This disclosure belongs to the field of intelligent medical device testing technology, and in particular relates to a low-dose liquid-free testing system, method and apparatus. Background Technology
[0002] The application of nebulized vaccines is becoming increasingly widespread, with its significant advantage being the reduction in drug dosage—only about one-fifth the amount required for injection. Currently available nebulized adenovirus vector recombinant COVID-19 vaccines require a single dose of only 0.1 ml. This characteristic not only eliminates the need for bottle packaging, solving the "bottleneck" problem in vaccine vial manufacturing, but also reduces the pressure on vaccine logistics and transportation.
[0003] However, most existing mesh nebulizers on the market are designed for chemical drugs, with liquid volumes typically ranging from 1-10 ml. Furthermore, the mist output direction is usually lateral or upward, resulting in a large residual liquid volume in the nebulizer plate, which cannot meet the nebulization requirements for extremely low vaccine doses. In addition, it is difficult to visually determine whether vaccine nebulization is complete. Failure to promptly instruct medical personnel may lead to aerosol precipitation and reduced vaccine activity, directly affecting the vaccination effect. More seriously, failing to stop energy output can shorten the nebulizer's lifespan and increase costs. Therefore, there is an urgent need to develop nebulization systems suitable for low doses. Summary of the Invention
[0004] The purpose of this disclosure is to provide a low-dose liquid-free detection system for a mesh nebulizer to solve the aforementioned problems. The system includes a data acquisition unit, an analysis unit, a calculation unit, a data storage unit, and an execution unit. The data storage unit stores data signals acquired or processed by the data acquisition unit, calculation unit, and analysis unit during operation, as well as pre-stored threshold data for the nebulizer plate. The data acquisition unit acquires current or voltage signals from the nebulizer plate over one or more cycles and sends them to the calculation unit. The calculation unit acquires the current or voltage signals sent by the data acquisition unit, obtains a fitting curve of the current or voltage signal change through differential calculation, and sends the fitting curve data to the analysis unit. The analysis unit receives the fitting curve data sent by the calculation unit, compares it with the pre-stored threshold data for the nebulizer plate in the data storage unit, makes a final judgment on whether the nebulizer is in a liquid-containing or liquid-free state, and sends the judgment result to the execution unit. The execution unit shuts down the system based on the final judgment of the analysis unit.
[0005] Specifically, the difference operation includes first-order derivative operation, second-order derivative operation and / or higher-order derivative operation.
[0006] Specifically, the first derivative operation involves the computing unit calculating the first derivative of the current signal, voltage signal, or operating frequency signal within one cycle to obtain the slope fitting curve of the current signal, voltage signal, or operating frequency signal.
[0007] Specifically, the second derivative operation of the difference is to calculate the second derivative of the difference between the current signal or voltage signal within one cycle by the computing unit, so as to obtain the fitting curve of the slope change rate of the current signal or voltage signal.
[0008] Specifically, the higher-order derivative operation of the difference is to calculate the higher-order derivative of the difference between the current signal or voltage signal within one cycle by the computing unit, so as to obtain the higher-order change fitting curve of the current signal or voltage signal.
[0009] Specifically, the nebulizer pre-stored threshold data in the data storage unit includes threshold data of the slope of change of the nebulizer current signal, voltage signal, or operating frequency signal within one cycle under the condition of having liquid medicine, and / or, threshold data of the slope of change rate of the nebulizer current signal or voltage signal within one cycle under the condition of having liquid medicine, and / or, threshold data of the higher-order derivative of the nebulizer current signal or voltage signal within one cycle under the condition of having liquid medicine.
[0010] Specifically, the liquid-free detection system also includes an initial judgment unit, which is used to make a preliminary judgment on whether the liquid is atomized or not by collecting the current or voltage signal of the atomizing plate within one or more cycles of the acquisition unit.
[0011] The final determination of whether there is drug atomization or not is specifically as follows: the analysis unit compares the first derivative operation with the slope threshold data of the atomizing plate current signal, voltage signal, or operating frequency signal in the data storage unit to determine whether it is a drug-free atomization state; or the analysis unit compares the first and second derivative operations with the slope threshold data and rate threshold data of the atomizing plate current signal or voltage signal in the data storage unit to determine whether it is a drug-free atomization state; or the analysis unit compares the first, second, and higher-order derivative operations with the slope threshold data, rate threshold data, and higher-order derivative threshold data of the atomizing plate current signal or voltage signal difference in the data storage unit to determine whether it is a drug-free atomization state.
[0012] Specifically, the final determination of whether there is drug atomization or not through current, voltage, or operating frequency signals includes:
[0013] The analysis unit continuously compares the result of the first derivative calculation with the pre-stored threshold data in the data storage unit to determine whether the atomization state is without medication. Specifically, if the result of the first derivative calculation exceeds the range of the pre-stored threshold data, it is considered that the current state is without medication, and execution stops. Or;
[0014] The analysis unit compares the first and second derivative calculations with the slope and rate of change threshold data of the nebulizer current or voltage signal in the data storage unit to determine whether the nebulization state is without medication. Specifically: if the first derivative calculation exceeds the pre-stored threshold data range, execution stops; if the first derivative calculation does not exceed the pre-stored threshold data range, the second derivative calculation is performed; if the second derivative calculation exceeds the pre-stored threshold data range, it is considered that the current state is without medication, and execution stops. Or;
[0015] The analysis unit compares the first-order, second-order, and higher-order derivative operations with the threshold data for the slope of change, the threshold data for the rate of change, and the threshold data for the higher-order derivative of the difference between the current or voltage signal of the nebulizer in the data storage unit to determine whether the nebulization state is without medication. The first-order, second-order, and higher-order derivative operations are continuously compared with the pre-stored threshold data in the data storage unit to determine whether the nebulization state is without medication. Specifically: if the first-order derivative operation exceeds the pre-stored threshold data range, the process stops; if the first-order derivative operation does not exceed the pre-stored threshold data range, the second-order derivative operation is performed; if the second-order derivative operation exceeds the pre-stored threshold data range, the current state is considered to be without medication, and the process stops; if the second-order derivative operation does not exceed the pre-stored threshold data range, the higher-order derivative operation is performed; if the higher-order derivative operation exceeds the pre-stored threshold data range, the process stops.
[0016] The present invention also provides a low-dose liquid-free detection method for a mesh nebulizer, comprising the following steps:
[0017] (1) The initial judgment of whether there is liquid atomization or no liquid atomization is made by collecting the current or voltage signal of the atomizing plate in one or more cycles of the acquisition unit.
[0018] (2) Acquire the current or voltage signal or operating frequency signal sent by the acquisition unit, and the calculation unit obtains the fitting curve of the change of the current or voltage signal through differential operation;
[0019] (3) Receive the change fitting curve data sent by the calculation unit, compare it with the threshold data of the atomizing plate in the data storage unit, make a final judgment on whether there is liquid atomization or no liquid atomization, and shut down the system based on the final judgment result;
[0020] (4) When it is determined that there is no liquid atomization or the state is unstable, an early warning will be issued and the process will be stopped.
[0021] Specifically, to further improve the detection system of the atomizing device, the detection system also includes: collecting atomization status information of the atomizing plate within one or more cycles; and determining whether the hardware is normal when the device is started by using the status of the operating frequency signal.
[0022] The present invention also provides a low-dose liquid-free detection device for a mesh nebulizer, comprising a system, an atomizing plate, a flexible circuit board, and the low-dose liquid-free detection system of the present invention.
[0023] The beneficial effects of this disclosure are that it improves the liquid-free detection system of the nebulizer by introducing an analysis unit, a calculation unit, and a data storage unit; it comprehensively analyzes and calculates the current or voltage signals of the nebulizer plate within one or more cycles, thereby improving the accuracy of liquid-free detection judgment; at the same time, it ensures complete vaccine nebulization and vaccine activity; the liquid-free detection system of this invention ensures the dosage of a single dose of vaccine and the activity of the nebulized vaccine, while also improving the ease of use for vaccination personnel, and increasing the service life of the nebulizer, thereby improving the overall cost, quality, and efficiency of nebulized vaccination. Attached Figure Description
[0024] Figure 1 This is a schematic diagram of the low-dose liquid-free detection circuit disclosed herein;
[0025] Figure 2 These are schematic diagrams of current waveforms under different operating conditions;
[0026] Figure 3 This is a schematic diagram of the current waveform from normal operating state to state without liquid medicine;
[0027] Figure 4 This is a schematic diagram of the voltage waveform from normal operating state to state without liquid medicine.
[0028] Figure 5 This is a schematic diagram of the operating frequency waveform from normal working state to the state without liquid medicine.
[0029] Figure 6 This is a flowchart of a low-dose liquid-free detection method disclosed herein;
[0030] Figure 7 This is a flowchart of the second low-dose liquid-free detection method disclosed herein;
[0031] Figure 8 This is a flowchart of the third low-dose liquid-free detection method disclosed herein. Detailed Implementation
[0032] The present application will now be described in further detail with reference to the accompanying drawings. It should be noted that the following specific embodiments are only used to further illustrate the present application and should not be construed as limiting the scope of protection of the present application. Those skilled in the art can make some non-essential improvements and adjustments to the present application based on the above application content.
[0033] like Figure 1As shown, a low-dose liquid-free detection system is disclosed, which includes a data acquisition unit, an analysis unit, an initial judgment unit, a calculation unit, and a data storage unit.
[0034] The acquisition unit is used to acquire atomization state information of the atomizing plate within one or more cycles and send it to the analysis unit. The atomization state information includes driving current signal, driving voltage signal, operating frequency signal, etc.
[0035] When the nebulizer is started, the electrical circuit consisting of PIN pins and a flexible circuit board outputs a high-frequency pulse signal to drive the nebulizer plate to resonate and vibrate, converting the liquid medicine into an aerosol.
[0036] During atomization, the acquisition unit monitors the atomizing plate in real time, including but not limited to the driving current, driving voltage, and operating frequency. The acquisition unit uses a current sensor, a voltage sensor, and an operating frequency sensor to acquire the driving current signal, driving voltage signal, and operating frequency signal in real time. The acquired signals are filtered to remove high-frequency noise by a low-pass filter circuit, converted into digital signals, and transmitted to the analysis unit.
[0037] The initial judgment unit is used to make a preliminary judgment on whether there is drug atomization or not by collecting the current or voltage signal of the atomizing plate of the acquisition unit. The main basis for the initial judgment unit to determine the drug atomization state is the driving current signal or voltage signal. The driving current or voltage is monitored and it is determined whether the current or voltage exceeds the threshold. If it exceeds the threshold, it is determined that there is no drug atomization state, the energy output is turned off, and a prompt is issued.
[0038] During the preprocessing process, based on the experimental results, the normal operating state threshold of the atomizer is stored in the data storage unit as threshold information for subsequent judgment.
[0039] like Figure 2 The operating state thresholds shown include a first operating state current threshold range [C1, C2], a second operating state current threshold range [C3, C4], and a third operating state current threshold range [C2, C3].
[0040] like Figure 3 The voltage threshold ranges for the first operating state [V1, V2], the second operating state [V3, V4], and the third operating state [V2, V3] are shown.
[0041] like Figure 4 The first operating state operating frequency threshold range [F1, F2], the second operating state voltage threshold range [F3, F4], and the third operating state voltage threshold range [F2, F3] are shown.
[0042] The current and voltage values within the threshold range of the second operating state represent the values of the state with drug atomization, while those within the threshold range of the first operating state represent the state without drug atomization. The current, voltage, and frequency values within the threshold range of the third operating state represent values requiring further judgment, which need to be analyzed using first-order derivative calculations, second-order derivative calculations, and higher-order derivative calculations.
[0043] Among them, C1, C2, C3, C4, V1, V2, V3, V4, F1, F2, F3, and F4 are all preset values based on materials, actual use, and working environment, that is, the threshold data of the atomizing plate pre-stored in the data storage unit.
[0044] The liquid-free detection system provided by this invention further includes an initial judgment unit. This initial judgment unit receives multiple time-point driving current or voltage signals sent by the acquisition unit, and then calculates the average current or voltage value from the received driving current signals. Specifically, the initial judgment unit compares the multiple average current or voltage values with operating state thresholds to determine whether the nebulizer is operating in a state with or without liquid atomization. If the average current or voltage value is within the first operating state current or voltage threshold range, it is determined to be in a state without liquid atomization, and the loop is exited, energy output is turned off, and the operating state is switched. If the average current or voltage value is within the second operating state current or voltage threshold range, it is determined to be in a state with liquid atomization, and the loop continues. If the average current or voltage value is within the third operating state current or voltage threshold range, all sampled values of the current and voltage signals are sent to the calculation unit.
[0045] The computing unit of the liquid-free detection system provided by this invention is used to acquire current or voltage signals or operating frequency signals sent by the acquisition unit, obtain a variation fitting curve of the current or voltage signals or operating frequency signals through differential operations, and send the variation fitting curve data to the analysis unit. The variation fitting curve data includes the slope of the current or voltage signals or operating frequency signals and / or the rate of change of the slope of the current or voltage signals and / or the higher-order derivative of the difference between the current or voltage signals within one period. The differential operations include first-order derivative operations, second-order derivative operations, or higher-order derivative operations. The first-order derivative operation involves the computing unit calculating the first derivative of the current or voltage signals or operating frequency within one period to obtain a slope fitting curve of the current or voltage signals or operating frequency, which is then sent to the analysis unit. The second-order derivative operation involves the computing unit calculating the second derivative of the difference between the current or voltage signals within one period to obtain a slope fitting curve of the current or voltage signals. The higher-order derivative operation of the difference is used by the computing unit to calculate the higher-order derivative of the difference between the current signal or voltage signal within one cycle, and obtain the higher-order change fitting curve of the current signal or voltage signal.
[0046] The liquid-free detection system of this invention can determine whether there is no drug liquid in the atomization state by using the first derivative of the current signal, voltage signal, or operating frequency signal. Specifically:
[0047] The first derivative of the current signal differential is: d(Cx-Cx') / d t2-t1 Where Cx is the current value at t1 and Cx' is the current value at t2.
[0048] The first derivative of the voltage signal differential is: d(Vx-Vx') / d t2-t1 Where Vx is the voltage value at t1 and Vx' is the voltage value at t2.
[0049] The first derivative of the operating frequency signal is: d(Fx-Fx') / d t2-t1 Where Fx is the operating frequency value of t1 and Fx' is the operating frequency value of t2.
[0050] Combination Figure 5 To illustrate the technical solution of this invention, the slope of the current change is used as an example. The slope of the current change over a fixed time interval is calculated (e.g., (AB) / (t1-t0)).
[0051] Compared with the slope threshold: If all slopes are within the current change slope threshold range, it indicates that the current change is stable and has not reached the liquid-free state standard. This invention can accurately determine the current change within the time interval t1-t0. Existing technologies cannot identify current or voltage changes in a short period of time, i.e., the third working state described above. Existing technologies can only identify when the device is stably in the first working state for a long time and then perform shutdown.
[0052] The liquid-free detection system of the present invention can determine whether the atomization state is without drug liquid by using the second derivative of the difference between the current signal and the voltage signal.
[0053] The second derivative of the differential current signal is: d 2 (Cx-Cx') / d t2-t1 2 Where Cx is the current value at t1 and Cx' is the current value at t2.
[0054] The second derivative of the voltage signal differential is: d 2 (Vx-Vx') / d t2-t1 2 Where Vx is the voltage value at t1 and Vx' is the voltage value at t2.
[0055] The analysis unit compares the results of the first and second derivative calculations with the slope threshold data and rate of change threshold data of the atomizing plate current signal or voltage signal in the data storage unit to determine whether it is a state of no drug atomization. Specifically: if the result of the first derivative calculation exceeds the range of the pre-stored threshold data, the process stops; if the result of the first derivative calculation does not exceed the range of the pre-stored threshold data, the second derivative calculation is performed; if the result of the second derivative calculation exceeds the range of the pre-stored threshold data, it is considered that the current state is a state of no drug atomization, and the process stops.
[0056] The liquid-free detection system of the present invention determines whether the atomization state is without drug liquid by comparing the results of first-order, second-order and higher-order derivative calculations with the data range of the slope threshold, rate of change threshold and higher-order derivative threshold data of the current or voltage signal of the atomizing plate in the data storage unit.
[0057] The higher-order derivative of the current signal differential is: d n (Cx-Cx') / d t2-t1 n Where Cx is the current value at t1 and Cx' is the current value at t2.
[0058] The second derivative of the voltage signal differential is: d n (Vx-Vx') / d t2-t1 nWhere Vx is the voltage value at t1 and Vx' is the voltage value at t2.
[0059] The analysis unit compares the results of the first-order, second-order, and higher-order derivative calculations with the threshold data for the slope and rate of change of the nebulizer current or voltage signal, and the threshold data range for the higher-order derivative of the current or voltage signal difference, stored in the data storage unit, to determine whether the nebulization is in a drug-free state. Specifically: if the first-order derivative calculation result exceeds the pre-stored threshold data range, the process stops; if the first-order derivative calculation result does not exceed the pre-stored threshold data range, the second-order derivative calculation is performed; if the second-order derivative calculation result exceeds the pre-stored threshold data range, the current state is considered to be drug-free, and the process stops; if the second-order derivative calculation result does not exceed the pre-stored threshold data range, the higher-order derivative calculation is performed; if the higher-order derivative calculation result exceeds the pre-stored threshold data range, the process stops.
[0060] This invention also provides a low-dose liquid-free detection method, specifically:
[0061] like Figure 6 As shown: Atomizer initialization; energy output, sampling module startup;
[0062] Sampling (driving current, driving voltage, frequency signal): Acquire atomization state information of the atomizing plate within one or more cycles and send it to the analysis unit. The atomization state information includes driving current signal, driving voltage signal, operating frequency signal, etc.
[0063] Specifically, when the nebulizer starts, an electrical circuit consisting of PIN pins and a flexible circuit board outputs a high-frequency pulse signal to drive the atomizing plate to resonate and vibrate, converting the liquid medicine into an aerosol. The sampling unit records extreme values and average values and transmits the data to the initial judgment unit. The initial judgment unit performs extreme value and average value judgments on the signals acquired by the sampling unit. If an abnormality is determined, energy is shut off, and nebulization stops.
[0064] If the condition is normal, the sampling unit monitors the atomizing plate in real time during the atomization process, including but not limited to signals such as drive current, drive voltage, and operating frequency. Using current sensors, voltage sensors, and operating frequency sensors, the drive current signal, drive voltage signal, and operating frequency signal are acquired in real time. After high-frequency noise is filtered out by a low-pass filter circuit, the acquired signals are converted into digital signals and transmitted to the computing unit.
[0065] The calculation unit is used to acquire the current or voltage signal or the atomizing plate operating frequency signal sent by the acquisition unit, obtain the change fitting curve of the current or voltage signal or the operating frequency signal through differential operation, and send the change fitting curve data to the analysis unit.
[0066] The analysis unit receives the variation fitting curve data sent by the calculation unit and compares it with the pre-stored threshold data of the atomizing plate in the data storage unit. It then makes a final judgment on whether the atomization state is with or without medication, and sends the final judgment result to the execution unit. Subsequently, the system shuts down based on the final judgment result. Specifically, the first derivative calculation result is continuously compared with the pre-stored threshold data in the data storage unit to determine whether the atomization state is without medication. If the first derivative calculation result exceeds the range of the pre-stored threshold data, the current state is considered to be without medication, and execution stops.
[0067] like Figure 7 As shown: Atomizer initialization; energy output, sampling module startup;
[0068] Sampling (driving current, driving voltage, frequency signal): Acquire atomization state information of the atomizing plate within one or more cycles and send it to the analysis unit. The atomization state information includes driving current signal, driving voltage signal, operating frequency signal, etc.
[0069] Specifically, when the nebulizer starts, an electrical circuit consisting of PIN pins and a flexible circuit board outputs a high-frequency pulse signal to drive the atomizing plate to resonate and vibrate, converting the liquid medicine into an aerosol. The sampling unit records extreme values and average values and transmits the data to the initial judgment unit. The initial judgment unit performs extreme value and average value judgments on the signals acquired by the acquisition unit. If an abnormality is determined, energy is shut off, and nebulization stops.
[0070] If the condition is normal, the sampling unit monitors the atomizing plate in real time during the atomization process, including but not limited to the driving current and driving voltage. Current and voltage sensors are used to acquire the driving current and driving voltage signals in real time. After high-frequency noise is filtered out by a low-pass filter circuit, the acquired signals are converted into digital signals and transmitted to the computing unit.
[0071] The calculation unit is used to acquire the current or voltage signal or the atomizing plate operating frequency signal sent by the acquisition unit, obtain the change fitting curve of the current or voltage signal through differential operation, and send the change fitting curve data to the analysis unit.
[0072] The analysis unit receives the variation fitting curve data sent by the calculation unit and compares it with the pre-stored threshold data of the atomizing plate in the data storage unit to make a final judgment on whether the atomization state is with or without medication, and sends the final judgment result to the execution unit. Subsequently, the system shuts down based on the final judgment result. Specifically, the results of the first derivative calculation and the second derivative calculation are continuously compared with the pre-stored threshold data in the data storage unit to determine whether it is a state without medication. Specifically: if the result of the first derivative calculation exceeds the range of the pre-stored threshold data, the execution stops; if the result of the first derivative calculation does not exceed the range of the pre-stored threshold data, the second derivative calculation is performed; if the result of the second derivative calculation exceeds the range of the pre-stored threshold data, it is considered that the current state is a state without medication, and the execution stops.
[0073] like Figure 8 As shown: Atomizer initialization; energy output, sampling module startup;
[0074] Sampling (driving current, driving voltage, frequency signal): Acquire atomization state information of the atomizing plate within one or more cycles and send it to the analysis unit. The atomization state information includes driving current signal, driving voltage signal, operating frequency signal, etc.
[0075] Specifically, when the nebulizer starts, an electrical circuit consisting of PIN pins and a flexible circuit board outputs a high-frequency pulse signal to drive the atomizing plate to resonate and vibrate, converting the liquid medicine into an aerosol. The sampling unit records extreme values and average values and transmits the data to the initial judgment unit. The initial judgment unit performs extreme value and average value judgments on the signals acquired by the acquisition unit. If an abnormality is determined, energy is shut off, and nebulization stops.
[0076] If the condition is normal, the sampling unit monitors the atomizing plate in real time during the atomization process, including but not limited to the driving current and driving voltage. Current and voltage sensors are used to acquire the driving current and driving voltage signals in real time. The acquired signals are filtered by a low-pass filter circuit to remove high-frequency noise, converted into digital signals, and transmitted to the computing unit.
[0077] The calculation unit is used to acquire the current or voltage signal or the atomizing plate operating frequency signal sent by the acquisition unit, obtain the change fitting curve of the current or voltage signal through differential operation, and send the change fitting curve data to the analysis unit.
[0078] The analysis unit receives the change fitting curve data sent by the calculation unit and compares it with the pre-stored threshold data of the atomizing plate in the data storage unit to make a final judgment on whether the atomization state is with or without medication, and sends the final judgment result to the execution unit. Subsequently, the system shuts down based on the final judgment result. Specifically, the results of the first-order derivative calculation, the second-order derivative calculation, and the higher-order derivative calculation are continuously compared with the pre-stored threshold data in the data storage unit to determine whether it is a state without medication. Specifically: if the first-order derivative calculation result exceeds the range of the pre-stored threshold data, execution stops; if the first-order derivative calculation result does not exceed the range of the pre-stored threshold data, the second-order derivative calculation is performed; if the second-order derivative calculation result exceeds the range of the pre-stored threshold data, it is considered that the current state is without medication, and execution stops; if the second-order derivative calculation result does not exceed the range of the pre-stored threshold data, the higher-order derivative calculation is performed; if the higher-order derivative calculation result exceeds the range of the pre-stored threshold data, execution stops.
[0079] This invention also provides a low-dose liquid-free detection device, including a system, an atomizing plate, a flexible circuit board, and the low-dose liquid-free detection system of this invention. The specific configuration is as follows:
[0080] (1) Ensure that the medicine cup is above the atomizing plate and the mist outlet is facing downwards.
[0081] (2) The mechanical structure at the atomization outlet should be designed to ensure the concentration of the liquid medicine, such as the angle of the wall of the liquid medicine cup, the size of the contact position between the liquid medicine cup and the atomizing plate, the material of the liquid medicine cup, and the addition of a lid to the liquid medicine cup, so as to ensure the atomization of low doses of liquid medicine.
[0082] The mechanical structure at the connection between the liquid cup and the atomizing plate can optimize the liquid concentration effect.
[0083] The angle of the medicine cup wall allows for precise control of the direction of medicine injection.
[0084] In particular, the size of the contact area between the medicine cup and the atomizing plate can be designed to prevent the medicine from dispersing.
[0085] Choosing the right material for the medicine cup can reduce the loss of medicine during adsorption.
[0086] Among the improvements, a lid was added to the medicine cup to reduce the evaporation of the medicine.
[0087] (3) The atomizing plate is connected by a flexible circuit board and is connected to the liquid-free detection system via a PIN pin.
[0088] The foregoing description illustrates and describes several preferred embodiments of the present invention. However, as previously stated, it should be understood that the present invention is not limited to the forms disclosed herein and should not be construed as excluding other embodiments. It can be used in various other combinations, modifications, and environments, and can be altered within the scope of the inventive concept described herein through the foregoing teachings or techniques or knowledge in related fields. Any modifications and variations made by those skilled in the art that do not depart from the spirit and scope of the present invention should be within the protection scope of the appended claims.
Claims
1. A low-dose liquid-free detection system for a mesh nebulizer, characterized in that, The system includes a data acquisition unit, an analysis unit, a calculation unit, a data storage unit, and an execution unit. The data storage unit stores data signals acquired or processed by the acquisition, calculation, and analysis units during operation, as well as pre-stored threshold data for the atomizing plate. The acquisition unit acquires current or voltage signals from the atomizing plate over one or more cycles and sends them to the calculation unit. The calculation unit acquires the current or voltage signals or the atomizing plate's operating frequency signals sent by the acquisition unit, obtains a variation fitting curve of the current or voltage signals or the operating frequency signals through differential operations, and sends the variation fitting curve data to the analysis unit. The analysis unit receives the variation fitting curve data sent by the calculation unit, compares it with the pre-stored threshold data for the atomizing plate in the data storage unit, makes a final judgment on whether the atomization state is with or without medication, and sends the judgment result to the execution unit. The execution unit shuts down the system based on the final judgment of the analysis unit.
2. The liquid-free detection system according to claim 1, characterized in that, The difference operations include first-order derivative operations, second-order derivative operations, and / or higher-order derivative operations.
3. The liquid-free detection system according to claim 2, characterized in that, The first derivative operation is to calculate the first derivative of the current signal, voltage signal, or operating frequency signal within one cycle by the computing unit, and obtain the slope fitting curve of the current signal, voltage signal, or operating frequency signal.
4. The liquid-free detection system according to claim 2, characterized in that, The second derivative operation of the difference is to calculate the second derivative of the difference between the current signal or voltage signal within one cycle by the computing unit, and obtain the slope change rate fitting curve of the current signal or voltage signal.
5. The liquid-free detection system according to claim 2, characterized in that, The higher-order derivative operation of the difference is used by the computing unit to calculate the higher-order derivative of the difference between the current signal or voltage signal within one cycle, and obtain the higher-order change fitting curve of the current signal or voltage signal.
6. The liquid-free detection system according to any one of claims 1-5, characterized in that, The pre-stored threshold data of the atomizing plate in the data storage unit includes threshold data of the slope of the change of the current signal, voltage signal or operating frequency signal of the atomizing plate in one cycle under the condition of having liquid medicine, and / or threshold data of the slope of the change rate of the current signal or voltage signal of the atomizing plate in one cycle under the condition of having liquid medicine, and / or threshold data of the higher-order derivative of the current signal or voltage signal of the atomizing plate in one cycle under the condition of having liquid medicine.
7. The liquid-free detection system according to any one of claims 1-6, characterized in that, It also includes an initial judgment unit, which is used to make a preliminary judgment on whether there is drug atomization or no drug atomization by collecting the current or voltage signal of the atomizing plate in one or more cycles of the acquisition unit.
8. The liquid-free detection system according to any one of claims 1-7, characterized in that, The final determination of whether there is a drug atomization state or not is specifically as follows: The analysis unit compares the first derivative calculation with the slope threshold data of the atomizing plate current signal, voltage signal, or operating frequency signal in the data storage unit to determine whether it is a state of no drug atomization; or The analysis unit compares the first and second derivative calculations with the slope threshold data and rate of change threshold data of the atomizing plate current signal or voltage signal in the data storage unit to determine whether it is a state of no drug atomization; or The analysis unit compares the first-order, second-order, and higher-order derivative operations with the data range of the slope threshold, rate of change threshold, and higher-order derivative threshold of the current or voltage signal difference of the atomizing plate in the data storage unit to determine whether it is a drug-free atomization state.
9. The liquid-free detection system according to claim 8, characterized in that, The result of the first derivative calculation is continuously compared with the pre-stored threshold data in the data storage unit to determine whether the state is one without drug atomization. Specifically: If the result of the first derivative calculation exceeds the range of the pre-stored threshold data, it is considered that the current state is one of no drug atomization, and the execution is stopped.
10. The liquid-free detection system according to claim 8, characterized in that, The results of the first and second derivative calculations are continuously compared with the pre-stored threshold data in the data storage unit to determine whether the atomization state is without medication. Specifically, if the result of the first derivative calculation exceeds the range of the pre-stored threshold data, the process stops; if the result of the first derivative calculation does not exceed the range of the pre-stored threshold data, the second derivative calculation is performed. If the result of the second derivative calculation exceeds the range of the pre-stored threshold data, the current state is considered to be without medication, and the process stops.
11. The liquid-free detection system according to claim 8, characterized in that, The step of continuously comparing the results of the first derivative, second derivative, and higher derivative calculations with the pre-stored threshold data in the data storage unit to determine whether the state is one without medication nebulization is as follows: if the result of the first derivative calculation exceeds the range of the pre-stored threshold data, the process stops; if the result of the first derivative calculation does not exceed the range of the pre-stored threshold data, the second derivative calculation is performed; if the result of the second derivative calculation exceeds the range of the pre-stored threshold data, then the current state is considered to be one without medication nebulization, and the process stops. If the result of the second derivative operation does not exceed the pre-stored threshold data range, the higher-order derivative operation is performed; if the result of the higher-order derivative operation exceeds the pre-stored threshold data range, the operation stops.
12. A low-dose liquid-free detection method for a mesh nebulizer, comprising the following steps: (1) The current or voltage signal of the atomizing plate is acquired by the acquisition unit to make a preliminary judgment on whether the liquid medicine is atomized or not. (2) Acquire the current or voltage signal or operating frequency signal sent by the acquisition unit, and the calculation unit obtains the fitting curve of the change of the current or voltage signal through differential operation; (3) Receive the change fitting curve data sent by the calculation unit, compare it with the threshold data of the atomizing plate in the data storage unit, make a final judgment on whether there is liquid atomization or no liquid atomization, and shut down the system based on the final judgment result; (4) If the state of no liquid medicine atomization is determined, an early warning will be issued and the process will be stopped.
13. A low-dose liquid-free detection device for a mesh nebulizer, comprising a system, an atomizing plate, a flexible circuit board, and a low-dose liquid-free detection system as claimed in any one of claims 1-11.