Double-drug-loading self-emulsifying soluble micro-needle, needle solution, and preparation method and application of double-drug-loading self-emulsifying soluble micro-needle

By encapsulating benzbromarone and colchicine in self-emulsifying soluble microneedles (B&C-SE@DMNs) and combining this with ultrasound treatment, the problems of uric acid control and drug release rate in gout treatment were solved, achieving rapid drug penetration and stable release, thus improving treatment efficacy and patient compliance.

CN120960123APending Publication Date: 2025-11-18BENGBU MEDICAL COLLEGE
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Patent Information

Application Number
CN202510739434.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-06-04
Publication Date
2025-11-18

AI Technical Summary

Technical Problem

Existing technologies are insufficient to effectively control uric acid concentration in gout patients. Traditional drugs are prone to triggering acute attacks or side effects during administration, and soluble microneedles have insufficient solubility and drug release rate, affecting treatment efficacy and patient compliance.

Method used

The self-emulsifying soluble microneedles (B&C-SE@DMNs) are used to encapsulate two drugs, benzbromarone, which is poorly soluble in water, and colchicine, which is soluble in water, in soluble microneedles. Combined with ultrasound treatment, the penetration and release of the drugs in the skin are promoted, forming a self-emulsifying drug release system, which improves the penetration and stability of the drugs.

Benefits of technology

It achieves rapid dissolution and deep retention of drugs in the skin, avoids gastrointestinal reactions and liver and kidney damage caused by oral medications, improves treatment efficacy and patient compliance, and achieves controlled release and enhanced penetration.

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Abstract

The invention relates to a needle solution for a double-drug-loading self-emulsifying drug release system and a preparation method thereof.The needle solution is obtained by mixing an SE solution and a water phase, and the SE solution is prepared from an oil phase solution obtained by dissolving a water-insoluble drug 1 in an oil ester organic solvent and a hydrotropy solution, the hydrotropy solution is a mixed solution of an emulsifier and a co-emulsifier; the water phase is an aqueous solution obtained by dissolving a water-soluble medicine 2 into water, and HA, Dex or Chs are added into the aqueous solution. The invention also relates to a drug-loaded soluble microneedle obtained from the needle solution, and also provides an application of the double drug-loaded soluble microneedle in preparation of drugs for treating gouty arthritis. The double-drug-loading microneedle prepared by the invention can obviously improve the corrosion speed in the skin and quickly release the drug, can play a role in promoting the drug permeation after being combined with the ultrasonic action, and can play a role in controlled release by controlling the demulsification release of the drug by utilizing the mechanical action of the ultrasonic.
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Citation Information

Patent Citations

  • Colchicine soluble microneedle patch and preparation method thereof

    CN113133991A