Traditional Chinese medicine composition for treating emaciation, weakness and drug resistance of tumor patients

Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating emaciation, weakness and drug resistance of tumor patients. The technical scheme is as follows: the traditional Chinese medicine composition for treating emaciation, weakness and drug resistance of tumor patients comprises proportioning components of the composition, the traditional Chinese medicine composition is a unique combined preparation capable of simultaneously solving the problems of weakness, emaciation and drug resistance of tumor patients, has a function of integrating multiple effects, is prepared from honeysuckle, dandelion and morinda citrifolia according to specific parts by weight, is prepared into an aqueous preparation by specific preparation methods such as three times of decoction, filtration, concentration and the like, and has the advantages of simple preparation process and low cost. The traditional Chinese medicine composition has the characteristics of improving physical ability, relieving mood, strengthening sleep quality and enhancing appetite, can quickly and effectively solve the problems occurring in the treatment period of tumor patients, and meanwhile, improves the treatment effect and prognosis, maintains the immune function of the patients, reduces complications, reduces the mortality risk caused by serious emaciation and improves long-term prognosis; in addition, drug resistance can be relieved, the effective treatment cycle and lifetime can be prolonged, and disease burden can be reduced.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and in particular to a traditional Chinese medicine composition for treating emaciation, weakness and drug resistance in cancer patients. Background Technology

[0002] The most feared problems during cancer treatment are: drug resistance, treatment side effects, tumor metastasis, and heterogeneity. These conditions are accompanied by a decline in tumor immune function, disease progression, and ultimately, painful death. Fatigue, weight loss, and drug resistance are very common among cancer patients during treatment. Although this varies due to different tumors, treatment regimens, and individual differences, fatigue is one of the most common and prevalent symptoms, occurring in approximately 60%-90% of patients in the early stages of treatment. Later, with the addition of drug side effects and changes in individual constitution, this phenomenon is almost universal, occurring in a high proportion and lasting for a long time, severely impacting quality of life and leading to patient deprivation. The patient is unable to perform daily activities such as eating, dressing, and walking, gradually losing the ability to care for themselves. This leads to interruption, delay, and reduced efficacy of treatment, causing anxiety, depression, and a vicious cycle of decreased immune function. The incidence of emaciation (weight loss ≥5%) is approximately 30%-80%, mostly occurring during treatment or in late-stage patients. Among these, 20%-40% will develop cachexia, such as in cases of stomach cancer, pancreatic cancer, and lung cancer. Due to the large-scale consumption of muscle and fat, immunity declines, resulting in organ damage, which seriously affects the continuity of treatment and prognosis, bringing endless panic and suffering to patients and their families. Moreover, this suffering increases significantly before death.

[0003] While existing Chinese medicine compositions can enhance nutrition, supplement nutritional preparations, or intervene with drugs, they suffer from drawbacks such as slow onset of action and temporary effectiveness. Furthermore, they cannot simultaneously and quickly (within three days) resolve issues such as fatigue, weight loss, and drug resistance experienced by cancer patients during treatment. If the patient's body cannot tolerate the medication, treatment must be temporarily or permanently discontinued. At the same time, treatments such as surgery and chemotherapy can cause reactions such as nausea, vomiting, and bone marrow suppression, affecting the patient's food intake and nutrient absorption, leading to nutritional deficiencies, weakened immune function, and decreased drug sensitivity, directly impacting the expected efficacy of the drugs.

[0004] To address the aforementioned issues, this treatment plan is currently the only combination formulation that can simultaneously resolve fatigue, weight loss, and drug resistance in cancer patients. It possesses multiple benefits and is composed of honeysuckle, dandelion, and noni fruit in specific weight proportions. Prepared through a specific process involving three decoctions, filtration, and concentration, it is formulated into an aqueous solution. This formulation enhances physical strength, soothes emotions, improves sleep quality, and increases appetite. It can quickly and effectively resolve problems encountered by cancer patients during treatment, ensuring the smooth progress of cancer treatment, improving fatigue and enhancing physical strength, helping patients resist the side effects of treatment, addressing weight loss and improving the patient's physical reserves, reducing treatment delays, dosage reductions, and treatment interruptions due to intolerance, and ensuring the smooth completion of the treatment course. Simultaneously, it improves treatment efficacy and prognosis, maintains the patient's immune function, reduces complications, lowers the risk of death due to severe weight loss, and improves long-term prognosis. Furthermore, it can alleviate drug resistance, prolong the effective treatment cycle and survival time, reduce the disease burden, provide more possibilities for subsequent treatments, optimize treatment plans, and create a virtuous cycle from improved physical fitness to active cooperation with treatment and ultimately, improved treatment efficacy. Summary of the Invention

[0005] To overcome the problems of fatigue, weight loss, and drug resistance that occur in cancer patients during treatment, existing Chinese medicine compositions, while able to enhance nutrition, supplement nutritional preparations, or intervene with drugs, suffer from drawbacks such as slow onset of action and temporary effectiveness. Furthermore, if the patient's body cannot tolerate the medication, treatment must be temporarily or permanently discontinued. At the same time, treatments such as surgery and chemotherapy can cause nausea, vomiting, and bone marrow suppression, affecting the patient's food intake and nutrient absorption, leading to nutritional deficiencies, weakened immune function, and decreased drug sensitivity, directly impacting the expected efficacy of the drugs.

[0006] The technical solution of the present invention is: a traditional Chinese medicine composition for treating emaciation, weakness and drug resistance in cancer patients, comprising the following raw materials in parts by weight: honeysuckle 2-5 parts, dandelion 1-3 parts, and noni fruit 3-8 parts.

[0007] Preferably, the composition comprises the following raw materials in parts by weight: 2-4 parts honeysuckle, 1-2 parts dandelion, and 3-6 parts noni fruit.

[0008] Preferably, the composition comprises the following raw materials in parts by weight: 3 parts honeysuckle, 2 parts dandelion, and 5 parts noni fruit.

[0009] As a preferred embodiment, a method for preparing a traditional Chinese medicine composition for treating emaciation, fatigue, and drug resistance in cancer patients includes the following steps:

[0010] S11: Weigh each raw material component precisely according to the preset weight ratio, and check whether the proportion of each component meets the formula requirements;

[0011] S12: Select a special decoction pot that conforms to the specifications for processing Chinese medicine, and preheat it evenly for 8-12 minutes under low heat to bring the pot to the appropriate decoction temperature.

[0012] S13: Select honeysuckle, dandelion and noni fruit that are 7 to 8 parts ripe, cut them into uniform pieces and put them into a preheated tank. Add 4 to 6 times the weight of the raw materials in purified water for the first time, stir thoroughly and then seal and soak for 60 to 90 minutes to allow the active ingredients to dissolve fully.

[0013] S14: Transfer the soaked material along with the decoction pot to the heating source, bring it to a boil quickly over high heat, then simmer over low heat for 30-60 minutes. Use a fine filter to separate the liquid from the residue, and place the liquid in a sterile container to cool naturally to room temperature.

[0014] S15: Perform a second decoction of the Chinese medicine decoction pot that has been cooled in S13. Add 3-5 times the weight of pure water to the remaining residue after filtering in S14 for the second decoction. First, bring the water to a boil over high heat, then simmer over low heat for 20-30 minutes. Filter out the liquid and residue with a strainer and let it cool temporarily.

[0015] S16: Perform a third decoction in the cooled Chinese medicine decoction pot of S14. Add 2-3 times the weight of pure water to the remaining filter residue after filtering in S15 for the third decoction. First, bring the water to a boil over high heat, then simmer over low heat for 20-30 minutes. Filter out the liquid and residue with a strainer and let it cool temporarily.

[0016] S17: Filter the liquid obtained from the decoctions in S14, S15 and S16 through a filter screen, mix the liquids and pour them into a Chinese medicine decoction pot. Heat over a low flame for 8-12 minutes with continuous stirring to concentrate the liquid to the required amount. Filter the liquid through a filter screen, cool it to room temperature, and package it into oral aqueous preparations according to dosage form requirements.

[0017] As a preferred option, in the raw material preparation stage of S11, honeysuckle and dandelion that meet the pharmacopoeia standards are selected first. The appearance of the raw materials is tested to see if they are clean, free of impurities and mold. Noni fruit should be selected with a maturity of seven to eight points. After slicing, it is placed in a cool and ventilated place to air dry naturally, avoiding direct sunlight. After air drying, it is washed with pure water to remove surface dust and impurities, and then drained for later use.

[0018] As a preferred method of administration, this traditional Chinese medicine composition is to be taken orally. The specific dosage and frequency of administration should be determined based on the individual patient's condition and under the guidance of a clinician.

[0019] As a preferred embodiment, the traditional Chinese medicine composition is used in the preparation of a drug for treating fatigue, emaciation, and drug resistance caused by immunodeficiency in cancer patients. The drug is characterized by enhancing the patient's energy, physical strength, appetite, and sleep quality by regulating the body's immune function.

[0020] As a preferred option, it can effectively and promptly control fatigue, weight loss, and drug resistance in cancer patients during the perioperative period, radiotherapy, chemotherapy, targeted therapy, and immunotherapy, and enable them to continue the course of treatment, increase the body's sensitivity to drugs, and prolong the time of drug resistance.

[0021] The beneficial effects of this invention are:

[0022] Currently, while existing traditional Chinese medicine (TCM) compositions can address the issues of fatigue, weight loss, and drug resistance experienced by cancer patients during treatment through nutritional support, supplementation, or drug intervention, these methods suffer from drawbacks such as slow onset of action and temporary effectiveness. Furthermore, if the patient's body cannot tolerate the medication, treatment must be temporarily or permanently discontinued. Simultaneously, treatments such as surgery and chemotherapy can trigger nausea, vomiting, and bone marrow suppression, affecting the patient's food intake and nutrient absorption, leading to nutritional deficiencies, weakened immune function, and decreased drug sensitivity, directly impacting the expected efficacy of drugs. This treatment plan is the only combination preparation that can simultaneously address the issues of fatigue, weight loss, and drug resistance in cancer patients. It possesses a multi-functional approach, composed of honeysuckle, dandelion, and noni fruit in specific weight proportions, prepared as an aqueous solution through a specific process involving three decoctions, filtration, and concentration. It features improved physical fitness, emotional relief, enhanced sleep quality, and increased appetite, effectively addressing problems encountered by cancer patients during treatment. It ensures the smooth progress of cancer treatment, improves fatigue and strengthens the body, helps patients resist treatment-related side effects, addresses emaciation and improves the body's reserves, reducing treatment delays, dosage reductions, and treatment interruptions due to intolerance, ensuring treatment is completed on schedule. Simultaneously, it improves treatment efficacy and prognosis, maintains the patient's immune function, reduces complications, lowers the risk of death due to severe emaciation, and improves long-term prognosis. Furthermore, it alleviates drug resistance, prolongs the effective treatment period and survival, reduces the disease burden, provides more possibilities for subsequent treatments, optimizes treatment plans, and fosters a positive cycle from improved physical fitness to active cooperation with treatment and enhanced treatment outcomes. Attached Figure Description

[0023] Figure 1 The diagram shows a preparation process of a traditional Chinese medicine composition for treating emaciation, weakness, and drug resistance in cancer patients according to the present invention. Detailed Implementation

[0024] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0025] Please see Figure 1 The present invention provides an embodiment of a traditional Chinese medicine composition for treating emaciation, weakness and drug resistance in cancer patients, comprising the following raw materials in parts by weight: honeysuckle 2-5 parts, dandelion 1-3 parts, and noni fruit 3-8 parts.

[0026] Preferably, the composition comprises the following raw materials in parts by weight: 2-4 parts honeysuckle, 1-2 parts dandelion, and 3-6 parts noni fruit.

[0027] Preferably, the composition comprises the following raw materials in parts by weight: 3 parts honeysuckle, 2 parts dandelion, and 5 parts noni fruit.

[0028] As a preferred embodiment, a method for preparing a traditional Chinese medicine composition for treating emaciation, fatigue, and drug resistance in cancer patients includes the following steps:

[0029] S11: Weigh each raw material component precisely according to the preset weight ratio, and check whether the proportion of each component meets the formula requirements;

[0030] S12: Select a special decoction pot that conforms to the specifications for processing Chinese medicine, and preheat it evenly for 8-12 minutes under low heat to bring the pot to the appropriate decoction temperature.

[0031] S13: Select honeysuckle, dandelion and noni fruit that are 7 to 8 parts ripe, cut them into uniform pieces and put them into a preheated tank. Add 4 to 6 times the weight of the raw materials in purified water for the first time, stir thoroughly and then seal and soak for 60 to 90 minutes to allow the active ingredients to dissolve fully.

[0032] S14: Transfer the soaked material along with the decoction pot to the heating source, bring it to a boil quickly over high heat, then simmer over low heat for 30-60 minutes. Use a fine filter to separate the liquid from the residue, and place the liquid in a sterile container to cool naturally to room temperature.

[0033] S15: Perform a second decoction of the Chinese medicine decoction pot that has been cooled in S13. Add 3-5 times the weight of pure water to the remaining residue after filtering in S14 for the second decoction. First, bring the water to a boil over high heat, then simmer over low heat for 20-30 minutes. Filter out the liquid and residue with a strainer and let it cool temporarily.

[0034] S16: Perform a third decoction in the cooled Chinese medicine decoction pot of S14. Add 2-3 times the weight of pure water to the remaining filter residue after filtering in S15 for the third decoction. First, bring the water to a boil over high heat, then simmer over low heat for 20-30 minutes. Filter out the liquid and residue with a strainer and let it cool temporarily.

[0035] S17: Filter the liquid obtained from the decoctions in S14, S15 and S16 through a filter screen, mix the liquids and pour them into a Chinese medicine decoction pot. Heat over a low flame for 8-12 minutes with continuous stirring to concentrate the liquid to the required amount. Filter the liquid through a filter screen, cool it to room temperature, and package it into oral aqueous preparations according to dosage form requirements.

[0036] As a preferred option, in the raw material preparation stage of S11, honeysuckle and dandelion that meet the pharmacopoeia standards are selected first. The appearance of the raw materials is tested to see if they are clean, free of impurities and mold. Noni fruit should be selected with a maturity of seven to eight points. After slicing, it is placed in a cool and ventilated place to air dry naturally, avoiding direct sunlight. After air drying, it is washed with pure water to remove surface dust and impurities, and then drained for later use.

[0037] As a preferred method of administration, this traditional Chinese medicine composition is to be taken orally. The specific dosage and frequency of administration should be determined based on the individual patient's condition and under the guidance of a clinician.

[0038] As a preferred embodiment, the traditional Chinese medicine composition is used in the preparation of a drug for treating fatigue, emaciation, and drug resistance caused by immunodeficiency in cancer patients. The drug is characterized by enhancing the patient's energy, physical strength, appetite, and sleep quality by regulating the body's immune function.

[0039] As a preferred option, it can effectively and promptly control fatigue, weight loss, and drug resistance in cancer patients during the perioperative period, radiotherapy, chemotherapy, targeted therapy, and immunotherapy, and enable them to continue the course of treatment, increase the body's sensitivity to drugs, and prolong the time of drug resistance.

[0040] Example 1

[0041] Background: Mr. Li, a patient with advanced non-small cell lung cancer undergoing chemotherapy, experienced a weight loss of 6 kg, severe fatigue, and chemotherapy resistance. He needed to improve his immune function to complete the course of treatment.

[0042] Implementation steps:

[0043] S21: Raw material preparation: 30g honeysuckle, 20g dandelion, 50g noni fruit (all meet the standard of no mold, noni fruit is 70% ripe, sliced, air-dried and then washed);

[0044] S22: Preheat the frying pot: Preheat over low heat for 10 minutes;

[0045] S23: First decoction: Soak in 300mL of purified water for 75 minutes, bring to a boil over high heat, then simmer over low heat for 45 minutes, and filter out the liquid;

[0046] S24: Second decoction: Add 200mL of purified water (4 times the amount of the residue), bring to a boil over high heat, then simmer over low heat for 25 minutes, and filter out the liquid;

[0047] S25: Third decoction: Add 100mL of purified water (2.5 times the amount of the residue), bring to a boil over high heat, then simmer over low heat for 25 minutes, and filter out the liquid;

[0048] S26: Concentration and Packaging: The mixture of liquids is heated and concentrated to 200mL, cooled, and then packaged for oral administration twice daily (100mL each time).

[0049] Data comparison table:

[0050]

[0051]

[0052] Example 2

[0053] Background: Zhang, a patient with advanced breast cancer, experienced a weight loss of 8 kg, persistent fatigue, and drug resistance after second-line chemotherapy, requiring improvement in treatment tolerance.

[0054] Implementation steps:

[0055] S31: Raw material preparation: 25g honeysuckle, 15g dandelion, 40g noni fruit (same as standard processing);

[0056] S32: Preheat the frying pot: Preheat over low heat for 8 minutes;

[0057] S33: First decoction: Add 240mL of purified water (6 times the amount of raw materials) and soak for 60 minutes. Bring to a boil over high heat, then simmer over low heat for 30 minutes.

[0058] S34: Second decoction: Add 120mL of purified water (3 times the amount of filtered residue), bring to a boil over high heat, then simmer over low heat for 20 minutes;

[0059] S35: Third decoction: Add 80mL of purified water (twice the amount of filtered residue), bring to a boil over high heat, then simmer over low heat for 20 minutes;

[0060] S36: Concentration and Packaging: The mixed juice is heated and concentrated to 180mL, and then packaged for oral administration twice daily (90mL each time).

[0061] Data comparison table:

[0062]

[0063]

[0064] The embodiments of the present invention have been described in detail above with reference to the accompanying drawings. However, the present invention is not limited to the above embodiments. Within the scope of knowledge possessed by those skilled in the art, various changes can be made without departing from the spirit of the present invention.

Claims

1. A traditional Chinese medicine composition for treating weight loss, fatigue, and drug resistance in cancer patients; characterized in that: The composition comprises the following raw materials in parts by weight: honeysuckle 2-5 parts, dandelion 1-3 parts, and noni fruit 3-8 parts.

2. The traditional Chinese medicine composition according to claim 1 for treating emaciation, fatigue, and drug resistance in cancer patients, characterized in that: The composition comprises the following raw materials in parts by weight: honeysuckle 2-4 parts, dandelion 1-2 parts, and noni fruit 3-6 parts.

3. The traditional Chinese medicine composition according to claim 2 for treating emaciation, fatigue, and drug resistance in cancer patients, characterized in that: The composition comprises the following raw materials in parts by weight: 3 parts honeysuckle, 2 parts dandelion, and 5 parts noni fruit.

4. A traditional Chinese medicine composition according to any one of claims 1-2 for treating emaciation, fatigue, and drug resistance in cancer patients, characterized in that: A method for preparing a traditional Chinese medicine composition for treating weight loss, fatigue, and drug resistance in cancer patients includes the following steps: S11: Weigh each raw material component precisely according to the preset weight ratio, and check whether the proportion of each component meets the formula requirements; S12: Select a special decoction pot that conforms to the specifications for processing Chinese medicine, and preheat it evenly for 8-12 minutes under low heat to bring the pot to the appropriate decoction temperature. S13: Select honeysuckle, dandelion and noni fruit that are 7 to 8 parts ripe, cut them into uniform pieces and put them into a preheated tank. Add 4 to 6 times the weight of the raw materials in purified water for the first time, stir thoroughly and then seal and soak for 60 to 90 minutes to allow the active ingredients to dissolve fully. S14: Transfer the soaked material along with the decoction pot to the heating source, bring it to a boil quickly over high heat, then simmer over low heat for 30-60 minutes. Use a fine filter to separate the liquid from the residue, and place the liquid in a sterile container to cool naturally to room temperature. S15: Perform a second decoction of the Chinese medicine decoction pot that has been cooled in S13. Add 3-5 times the weight of pure water to the remaining residue after filtering in S14 for the second decoction. First, bring the water to a boil over high heat, then simmer over low heat for 20-30 minutes. Filter out the liquid and residue with a strainer and let it cool temporarily. S16: Perform a third decoction in the cooled Chinese medicine decoction pot of S14. Add 2-3 times the weight of pure water to the remaining filter residue after filtering in S15 for the third decoction. First, bring the water to a boil over high heat, then simmer over low heat for 20-30 minutes. Filter out the liquid and residue with a strainer and let it cool temporarily. S17: Filter the liquid obtained from the decoctions in S14, S15 and S16 through a filter screen, mix the liquids and pour them into a Chinese medicine decoction pot. Heat over a low flame for 8-12 minutes with continuous stirring to concentrate the liquid to the required amount. Filter the liquid through a filter screen, cool it to room temperature, and package it into oral aqueous preparations according to dosage form requirements.

5. A traditional Chinese medicine composition according to claim 4 for treating emaciation, fatigue, and drug resistance in cancer patients, characterized in that: In the raw material preparation stage of S11, honeysuckle and dandelion that meet the pharmacopoeia standards are selected first. The appearance of the raw materials is tested to see if they are clean, free of impurities and mold. Noni fruit should be selected with a maturity of seven to eight points. After slicing, it is placed in a cool and ventilated place to air dry naturally, avoiding direct sunlight. After air drying, it is washed with pure water to remove surface dust and impurities, and then drained for later use.

6. A traditional Chinese medicine composition according to claim 3 for treating emaciation, fatigue, and drug resistance in cancer patients, characterized in that: This traditional Chinese medicine composition is administered orally. The specific dosage and frequency should be determined based on the individual patient's condition and under the guidance of a clinician.

7. A traditional Chinese medicine composition according to claim 3 for treating emaciation, fatigue, and drug resistance in cancer patients, characterized in that: The aforementioned traditional Chinese medicine composition is used in the preparation of a drug for treating fatigue, weight loss, and drug resistance caused by immunodeficiency in cancer patients. The drug is characterized by enhancing the patient's energy, physical strength, appetite, and sleep quality by regulating the body's immune function.

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