Traditional Chinese medicine composition for treating thyroid nodule and application

Abstract

The invention relates to a traditional Chinese medicine composition for treating thyroid nodules and application, and belongs to the technical field of pharmacy, the formula of the traditional Chinese medicine composition comprises wild buckwheat rhizome, pseudo-ginseng, dysosma versipellis, kadsura longepedunculata, rhizoma cyperi, armadillidiam vulgare, paederia scandens and black ants, pseudo-ginseng has strong strength of promoting blood circulation to remove blood stasis and relieving swelling and pain, and has the effect of aiming at the core pathogenesis of diseases, namely blood stasis; the rhizoma fagopyri dibotryis has the effects of clearing away heat and toxic materials, promoting blood circulation, eliminating carbuncle, tonifying spleen and promoting diuresis, has good anti-hyperplasia and anti-tumor activity, and has a good effect of eliminating stagnation when cooperating with the pseudo-ginseng, and the monarch drug can play the effects of soothing liver and regulating qi, promoting blood circulation to remove blood stasis, softening hardness to dissipate stagnation, reducing phlegm and clearing damp when cooperating with other formula drugs, and has an obvious curative effect on thyroid nodules; the curative effect is also achieved on pulmonary nodules.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical technology, specifically to a traditional Chinese medicine composition for treating thyroid nodules and its application. Background Technology

[0002] The incidence of thyroid nodules in Chinese residents is approximately 32.4%, and this rate has been increasing year by year in recent years. This disease is more common in the elderly and women, and it has a serious impact on patients' normal lives and mental and physical health. Current clinical treatments for nodular goiter mainly include minimally invasive interventional therapy, surgical treatment, suppression therapy, and regular follow-up. Traditional Chinese medicine has thousands of years of experience in treatment and has good efficacy. It can improve patients' symptoms, suppress or shrink nodules, and reduce the risk of malignant transformation.

[0003] In Traditional Chinese Medicine (TCM) theory, thyroid nodules are mostly classified under the category of "goiter." Their pathogenesis is mainly related to the following factors: Qi stagnation and blood stasis: Long-term emotional distress (liver qi stagnation) leads to obstructed qi and blood circulation, causing stagnation in the neck. Phlegm accumulation: Spleen dysfunction leads to internal retention of dampness, which condenses into phlegm, and phlegm and qi stagnation accumulate in the front of the neck. Deficiency of vital energy: Liver and kidney yin deficiency or insufficient qi and blood reduces the body's regulatory capacity, making phlegm and blood stasis more likely to accumulate.

[0004] Liver qi stagnation is the core contributing factor. Traditional Chinese medicine believes that "the liver governs the free flow of qi," and prolonged emotional depression, anxiety, or excessive stress can lead to liver qi stagnation, hindering the smooth flow of qi. Qi stagnation obstructs the circulation of body fluids and blood, gradually forming phlegm and blood stasis, which accumulate in the neck (thyroid region), eventually developing into nodules. Therefore, the core treatment principle of thyroid nodules in traditional Chinese medicine is: soothing the liver and regulating qi, promoting blood circulation and removing blood stasis, softening and dispersing nodules, and resolving phlegm and dampness. Therefore, it is essential to disclose a traditional Chinese medicine composition for treating thyroid nodules and prepare it into a convenient Chinese medicine preparation. Summary of the Invention

[0005] To overcome the problems existing in the background art, the present invention discloses a traditional Chinese medicine composition for treating thyroid nodules. The traditional Chinese medicine composition is effective for thyroid nodules, especially nodules associated with Hashimoto's thyroiditis, which are closely related to local inflammation and immune disorders. Buckwheat is cool in nature and has a pungent and astringent taste. Its core functions are clearing heat and detoxifying, promoting blood circulation and eliminating carbuncles, and dispelling wind and dampness. The effects of buckwheat in "promoting blood circulation" and "detoxifying and dispersing nodules" directly target the "stasis" and "heat toxin" of the nodules. The active ingredients in buckwheat, such as flavonoids and tannins, can inhibit the release of inflammatory factors (such as TNF-α and IL-6), regulate the body's immune function, thereby reducing inflammatory damage to thyroid tissue and inhibiting nodule growth. The "blood-activating and stasis-removing" effects of buckwheat are reflected in its ability to improve local blood circulation, increase blood oxygen supply, promote the removal of metabolic waste, and help improve the environment around nodules and their absorption. The effective components in the roots and stems of buckwheat are a mixture of condensed tannins of proanthocyanidins, which have strong anti-cancer activity and can inhibit the lung metastasis and invasion of tumor cells. In the formula, woodlice have a significant analgesic effect, can inhibit the activity of monoamine oxidase in tissues, and inhibit the formation of collagen fibers. Podophyllum hexandrum has anti-inflammatory, antibacterial and blood-activating effects, and contains podophyllotoxin, which has anti-tumor activity.

[0006] To achieve the above objectives, the present invention is implemented through the following technical solution: The traditional Chinese medicine composition for treating thyroid nodules is characterized in that the composition comprises the following raw materials in parts by weight: buckwheat: 150-250 parts, Panax notoginseng: 50-150 parts, Podophyllum hexandrum: 50-150 parts, Spatholobus suberectus: 150-250 parts, Cyperus rotundus: 100-200 parts, Armadillidium vulgare: 50-150 parts, Paederia scandens: 150-300 parts, and black ants: 50-150 parts.

[0007] Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: buckwheat: 245 parts, Panax notoginseng: 125 parts, Podophyllum hexandrum: 125 parts, Spatholobus suberectus: 110 parts, Cyperus rotundus: 110 parts, Armadillidium vulgare: 85 parts, Paederia scandens: 110 parts, and black ants: 85 parts.

[0008] Preferably, the root and leaves of buckwheat are used together in the traditional Chinese medicine composition.

[0009] Preferably, the traditional Chinese medicine composition is prepared into capsules for later use.

[0010] Preferably, the method for preparing the capsules includes the following steps: (1) Preparation of medicinal slices: Five-spice vine, chicken dung vine, buckwheat, Da Hong Pao, Bupleurum, Panax notoginseng, Cyperus rotundus and Podophyllum hexandrum were selected, washed, cut and dried to obtain medicinal slices of five-spice vine, chicken dung vine, buckwheat, Da Hong Pao, Bupleurum, Panax notoginseng, Cyperus rotundus and Podophyllum hexandrum. (2) Preparation of thick extract: Mix the sliced ​​herbs of five-spice vine, chicken dung vine, buckwheat, Da Hong Pao, and Bupleurum, add 6-8 times the total amount of water to soak for 1.0-2.0 hours, decoct for 1.5-2.5 hours, filter to obtain filtrate, add 4-6 times the total amount of water to the dregs and decoct a second time for 1.5-2 hours, filter to obtain filtrate, discard the dregs and combine the filtrates, heat and concentrate to obtain thick extract.

[0011] (3) Grinding: The sliced ​​Panax notoginseng, sliced ​​Cyperus rotundus, and sliced ​​Podophyllum hexandrum were crushed and sieved to obtain fine powder of Panax notoginseng, fine powder of Cyperus rotundus, and fine powder of Podophyllum hexandrum; the woodlice and black ants were selected, crushed, sieved and sterilized to obtain fine powder of woodlice and fine powder of black ants. (4) Mixing and granulation: The thick extract is mixed with Panax notoginseng powder, Cyperus rotundus powder, Podophyllum hexandrum powder, Armadillidium vulgare powder and black ant powder, moistened with 85% ethanol, granulated, dried at 60-70℃, granulated, filled into capsules, and packaged to obtain capsules.

[0012] Preferably, the capsules are 1.6g / capsule.

[0013] As a preferred option, the dosage of the capsules is 1.6g each time, 3 times a day, for 30 consecutive days as one course of treatment.

[0014] Preferably, the traditional Chinese medicine composition is effective for thyroid nodules and pulmonary nodules.

[0015] The beneficial effects of this invention: The mechanism of action of the traditional Chinese medicine composition for treating thyroid nodules is as follows: The principal ingredients are buckwheat and Panax notoginseng. As the core of the formula, the principal ingredients have the effects of promoting blood circulation, removing blood stasis, dispersing nodules, and reducing swelling. Panax notoginseng has a strong effect of promoting blood circulation, removing blood stasis, reducing swelling, and relieving pain, and can target the core pathogenesis of the disease, "blood stasis". Buckwheat clears heat and detoxifies, promotes blood circulation, eliminates carbuncles, strengthens the spleen, and promotes diuresis. It has good anti-proliferation and anti-tumor activity, and works synergistically with Panax notoginseng to have a good effect of dispersing nodules. The assistant ingredients are Podophyllum hexandrum, Spatholobus suberectus, and Cyperus rotundus. The assistant ingredients assist the principal ingredients in achieving the effects of promoting qi and blood circulation, softening and dispersing nodules. Podophyllum hexandrum has the effects of clearing heat and detoxifying, promoting blood circulation, removing blood stasis, dispersing nodules, and relieving pain. It has a strong effect of dispersing nodules. Spatholobus suberectus has the effects of clearing heat and detoxifying, promoting blood circulation, removing blood stasis, dispersing nodules, and relieving pain. This formula has the effects of promoting qi and blood circulation, dispelling wind and dampness, and enhancing the overall effect of promoting qi and blood circulation. When qi flows, blood flows, and when blood flows, stagnation dissipates. Cyperus rotundus has the effects of soothing the liver and relieving depression, regulating qi and relieving chest congestion, regulating menstruation and relieving pain, and is effective for symptoms of "liver qi stagnation". The adjuvant herbs are woodlice and Paederia scandens, which have the effects of detoxification and pain relief. Woodlice has the effects of breaking up blood stasis and eliminating masses, and detoxification and pain relief. Woodlice is good at penetrating and can penetrate deep into the collaterals to break up stubborn blood stasis. Paederia scandens has the effects of dispelling wind and promoting blood circulation, relieving pain and detoxifying, and promoting digestion and relieving stagnation. The analgesic effect of Paederia scandens can effectively relieve the patient's pain symptoms, while also helping to eliminate masses. The guiding herb is black ant, which can play a role in removing blood stasis, clearing the collaterals, calming and anti-inflammatory effects. The interaction of the herbs in this Chinese medicine composition can play a role in soothing the liver and regulating qi, promoting blood circulation and removing blood stasis, softening and dispersing masses, and resolving phlegm and dampness, and has a significant therapeutic effect on thyroid nodules. Detailed Implementation

[0016] To make the above objectives, technical solutions, and beneficial effects clearer and more explicit, the present invention will be specifically described below in conjunction with embodiments.

[0017] Example 1: Preparation of capsules for treating thyroid nodules The preparation of capsules includes the following steps: (1) Preparation of medicinal slices: Take 150 parts of buckwheat, 150 parts of Panax notoginseng, 150 parts of Podophyllum hexandrum, 250 parts of Ficus pumila, 200 parts of Cyperus rotundus, 50 parts of woodlice, 150 parts of Paederia scandens, and 50 parts of black ants; select, wash, cut and dry Ficus pumila, Paederia scandens, buckwheat, Da Hong Pao (a type of herb), Bupleurum chinense, Panax notoginseng, Cyperus rotundus and Podophyllum hexandrum to obtain medicinal slices of Ficus pumila, Paederia scandens, buckwheat, Da Hong Pao, Bupleurum chinense, Panax notoginseng, Cyperus rotundus and Podophyllum hexandrum; (2) Preparation of thick extract: Mix the slices of five-spice vine, chicken dung vine, buckwheat, Da Hong Pao, and Bupleurum, add 6 times the amount of water of the total amount of the slices and soak for 1.0 hour, decoct for 1.5 hours, filter to obtain filtrate, add 4 times the amount of water of the total amount of the dregs and decoct a second time for 1.5 hours, filter to obtain filtrate, discard the filter residue and combine the filtrate, heat and concentrate to obtain thick extract.

[0018] (3) Grinding: The sliced ​​Panax notoginseng, sliced ​​Cyperus rotundus, and sliced ​​Podophyllum hexandrum were crushed and sieved to obtain fine powder of Panax notoginseng, fine powder of Cyperus rotundus, and fine powder of Podophyllum hexandrum; the woodlice and black ants were selected, crushed, sieved and sterilized to obtain fine powder of woodlice and fine powder of black ants. (4) Mixing and granulation: The thick extract is mixed with Panax notoginseng powder, Cyperus rotundus powder, Podophyllum hexandrum powder, Armadillidium vulgare powder and black ant powder, moistened with 85% ethanol, granulated, dried at 60℃, granulated, and filled into capsules at a specification of 1.6g / capsule, and packaged to obtain capsules.

[0019] Example 2: Preparation of capsules for treating thyroid nodules The preparation of capsules includes the following steps: (1) Preparation of medicinal slices: Take 245 parts of buckwheat, 125 parts of Panax notoginseng, 125 parts of Podophyllum hexandrum, 110 parts of five-spice vine, 110 parts of Cyperus rotundus, 85 parts of woodlice, 110 parts of chicken dung vine, and 85 parts of black ants respectively; select, wash, cut and dry the five-spice vine, chicken dung vine, buckwheat, Da Hong Pao, Bupleurum, Panax notoginseng, Cyperus rotundus and Podophyllum hexandrum to obtain the medicinal slices of five-spice vine, chicken dung vine, buckwheat, Da Hong Pao, Bupleurum, Panax notoginseng, Cyperus rotundus and Podophyllum hexandrum; (2) Preparation of thick extract: Mix the slices of five-spice vine, chicken dung vine, buckwheat, Da Hong Pao, and Bupleurum, add 7 times the amount of water of the slices and soak for 2.0 hours, decoct for 2.5 hours, filter to obtain filtrate, add 5 times the amount of water of the dregs and decoct a second time for 2 hours, filter to obtain filtrate, discard the dregs and combine the filtrate, heat and concentrate to obtain thick extract.

[0020] (3) Grinding: The sliced ​​Panax notoginseng, sliced ​​Cyperus rotundus, and sliced ​​Podophyllum hexandrum were crushed and sieved to obtain fine powder of Panax notoginseng, fine powder of Cyperus rotundus, and fine powder of Podophyllum hexandrum; the woodlice and black ants were selected, crushed, sieved and sterilized to obtain fine powder of woodlice and fine powder of black ants. (4) Mixing and granulation: The thick extract is mixed with fine powders of Panax notoginseng, Cyperus rotundus, Podophyllum hexandrum, Armadillidium vulgare, and black ant. The mixture is moistened with 85% ethanol, granulated, dried at 65°C, sized, filled into capsules, and packaged to obtain capsules. Capsules are filled and packaged at a specification of 1.6g / capsule to obtain capsules.

[0021] Example 3: Preparation of capsules for treating thyroid nodules The preparation of capsules includes the following steps: (1) Preparation of medicinal slices: Take 200 parts of buckwheat, 100 parts of Panax notoginseng, 100 parts of Podophyllum hexandrum, 170 parts of five-spice vine, 100 parts of Cyperus rotundus, 60 parts of woodlice, 60 parts of chicken dung vine, and 60 parts of black ants respectively; select, wash, cut and dry the five-spice vine, chicken dung vine, buckwheat, Da Hong Pao, Bupleurum, Panax notoginseng, Cyperus rotundus and Podophyllum hexandrum to obtain the medicinal slices of five-spice vine, chicken dung vine, buckwheat, Da Hong Pao, Bupleurum, Panax notoginseng, Cyperus rotundus and Podophyllum hexandrum; (2) Preparation of thick extract: Mix the slices of five-spice vine, chicken dung vine, buckwheat, Da Hong Pao, and Bupleurum, add 8 times the amount of water of the total amount of the slices and soak for 2.0 hours, decoct for 2.5 hours, filter to obtain filtrate, add 6 times the amount of water of the total amount of the dregs and decoct a second time for 2 hours, filter to obtain filtrate, discard the dregs and combine the filtrate, heat and concentrate to obtain thick extract.

[0022] (3) Grinding: The sliced ​​Panax notoginseng, sliced ​​Cyperus rotundus, and sliced ​​Podophyllum hexandrum were crushed and sieved to obtain fine powder of Panax notoginseng, fine powder of Cyperus rotundus, and fine powder of Podophyllum hexandrum; the woodlice and black ants were selected, crushed, sieved and sterilized to obtain fine powder of woodlice and fine powder of black ants. (4) Mixing and granulation: The thick extract is mixed with fine powders of Panax notoginseng, Cyperus rotundus, Podophyllum hexandrum, Armadillidium vulgare, and black ant. The mixture is moistened with 85% ethanol, granulated, dried at 70°C, sized, filled into capsules, and packaged to obtain capsules. Capsules are filled and packaged at a specification of 1.6g / capsule to obtain capsules.

[0023] Example 4: Verification of the efficacy of capsule formulation in rat experiments A rat model of nodular goiter was established by inducing the pathological state of nodular goiter in rats using a low-iodine diet. Seventy-two male SD rats weighing 120-140g and in good health were selected and housed in the laboratory in cages of six. All rats were fed a low-iodine diet and given deionized water. The rats were divided into six groups of 12 each and numbered 1#, 2#, 3#, 4#, 5#, and 6#. The low-iodine diet led to insufficient synthesis of thyroid hormones, resulting in elevated TSH and thyroid hyperplasia. Doppler observation showed that the rats had enlarged thyroid volume, follicular epithelial cell proliferation, interstitial angiogenesis, increased blood supply under TSH stimulation, and nodular structures with uneven proliferation, forming nodules of varying sizes.

[0024] Rats #1, #2, and #3 were the treatment group. They were fed normal rat feed and deionized water, and simultaneously given capsules prepared in Examples 1, 2, and 3. Rats #1 were given capsules prepared in Example 1, rats #2 were given capsules prepared in Example 3, and rats #3 were given capsules prepared in Example 3. The dosage and administration of the capsules in Examples 1, 2, and 3 were as follows: 1.6g each time, three times a day, for 30 days as one course of treatment. Rats #1, #2, and #3 received three courses of the capsules.

[0025] Rats #4, #5, and #6 served as the control group, and were fed normal rat feed and deionized water. The feeding change time for rats #4, #5, and #6 was synchronized with that of rats #1, #2, and #3. After 90 days, the thyroid glands of rats #1, #2, #3, #4, #5, and #6 were observed using Doppler ultrasound. Subsequently, the thyroid tissues of rats #1, #2, #3, #4, #5, and #6 were dissected and the results were recorded. The results are shown in Table 1. Example 4 established a rat model of nodular goiter and intervened with a traditional Chinese medicine composition that has the effects of resolving phlegm, dispersing nodules, and promoting blood circulation and removing blood stasis. This composition, specifically the capsules prepared in Examples 1, 2, and 3, effectively improved the tissue structure of the thyroid gland, reduced its weight, inhibited excessive proliferation of follicular epithelial cells, promoted colloid storage, reduced interstitial fibrosis and inflammatory infiltration, and restored the abnormal tissue structure to a normal morphology. It showed significant therapeutic effects on thyroid nodules in rats #1, #2, and #3.

[0026] Implementation 5: Clinical Trials Based on the experimental results of rat experiments in Example 4, it can be seen that the capsules prepared in Examples 1, 2 and 3 are effective against thyroid nodules in rats and have no obvious toxic reactions, so they can be used for clinical trials.

[0027] 120 patients with nodular goiter admitted to a hospital from March 2023 to March 2024 were selected as the subjects for this study. They were divided into a control group and an observation group, with 60 patients in each group, based on different treatment methods. The control group received additional treatment with Wei Dan Zhi Xiao Yao San, while the observation group received additional treatment with capsules prepared according to Examples 1, 2, and 3. In the control group, there were 35 males and 25 females, aged 40–48 years, with a mean age of (44.63±1.41) years. In the observation group, there were 36 males and 24 females, aged 41–48 years, with a mean age of (44.52±1.42) years. There were no statistically significant differences in general characteristics between the two groups (P>0.05). All patients were informed about the study, and the study was approved and supervised by the hospital's ethics committee.

[0028] Those meeting the relevant diagnostic criteria. Western Medicine Diagnostic Criteria: ① Normal thyroid function and hormone levels upon clinical examination; ② Thyroid ultrasound examination reveals nodules or tumor-like masses; ③ Thyroid examination shows unilateral or bilateral enlargement, with palpable, soft, non-tender, and well-defined borders, moving up and down with swallowing; ④ No symptoms of redness, swelling, heat, or pain, moving up and down with swallowing, but occasional shortness of breath or other discomfort. Traditional Chinese Medicine Diagnostic Criteria: Meets the TCM diagnostic criteria for "goiter," classified as qi stagnation and phlegm obstruction. Exclusion Criteria: ① Allergic to the treatment medication; ② Pregnant or breastfeeding; ③ Abnormal liver or kidney function; ④ Poor cooperation.

[0029] The control group received additional treatment with Jiawei Danzhi Xiaoyao San, decocting the medicine in cold water to 200mL, one dose per day, divided into two doses, morning and evening. Both groups received continuous treatment for 90 days. The treatment group also received the capsules described in Examples 1, 2, and 3, administered as follows: 1.6g per capsule, three times daily, for 30 days as one course of treatment. The treatment group received three courses of capsules. The treatment results were compared between the two groups. Marked effect: The mass was not palpable, and ultrasound examination showed a mass diameter <3cm, with symptoms disappearing; Effective: Ultrasound examination showed a mass diameter reduction of ≥60%, with significant symptom relief; Ineffective: No significant change. Effective rate = (Number of markedly effective + number of effective cases) / Total number of cases × 100%. The total symptom scores of the two groups were compared. The main symptoms included neck distension, phlegm in the throat, chest tightness, poor appetite, breast distension and pain, and stabbing pain in the chest and ribs. Symptoms or signs were classified into three levels: mild, moderate, and severe, scored as 2, 4, and 6 points respectively. If no such symptoms or signs were present, it was considered normal and scored as 0 points. Other symptoms included a dark red tongue or petechiae, a thin white or greasy white coating, and a suspended, slippery, or deep and hesitant pulse, scored as either present or absent, with a score of 1 or 0 points. The maximum score was 45 points. Data were recorded once before and once after treatment, with lower scores being better. Data were processed using SPSS 20.0 statistical software. Measurement data were expressed as (x-±s) and analyzed using t-tests; count data were expressed as [n (%)] and analyzed using chi-square tests. A p-value < 0.05 was considered statistically significant. The treatment results of the two groups of patients were compared as follows.

[0030] The effective rate of treatment in the treatment group was higher than that in the control group, and the difference was statistically significant (P<0.05); see Table 1.

[0031] The total symptom score of the treatment group was lower than that of the control group, and the difference was statistically significant (P<0.05); see Table 2.

[0032] Nodular goiter is a common clinical disease, falling under the category of "goiter" in Traditional Chinese Medicine (TCM). Currently, it is generally believed that blood stasis, phlegm accumulation, and qi stagnation are key aspects of its diagnosis and treatment, with qi stagnation being the most prominent, as it leads to phlegm accumulation and blood stasis. Some scholars believe that the pathogenesis of thyroid nodules lies in the liver, and treatment should focus on regulating the liver and spleen. Other scholars suggest that the disease is the result of the interaction of qi, phlegm, and blood stasis. The capsules prepared in Examples 1, 2, and 3 are effective formulas derived from years of experience by physicians. These capsules have the effects of clearing heat, soothing the liver, and relieving depression. In treating nodular goiter, they harmonize the liver and spleen, and soothe the liver and relieve depression. The spleen and stomach have a digestive function, and the liver has a regulating function. By eliminating phlegm accumulation and qi stagnation, the enlargement of nodules is further inhibited. The capsules prepared in Examples 1, 2, and 3 can further shrink and soften nodules.

[0033] The experimental results of Example 5 showed that the effective rate of treatment in the treatment group was higher than that in the control group, and the difference was statistically significant (P<0.05). The results also showed that the total symptom score in the study group was lower than that in the control group, and the difference was statistically significant (P<0.05). Therefore, the capsules prepared in Examples 1, 2, and 3 are significantly effective in treating nodular goiter, significantly reducing symptom scores and adverse reactions. In conclusion, the capsules prepared in Examples 1, 2, and 3 are significantly effective in treating nodular goiter and are worthy of clinical application.

[0034] Finally, it should be noted that the above preferred embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail through the above preferred embodiments, those skilled in the art should understand that various changes can be made to it in form and detail without departing from the scope defined by the claims of the present invention.

Claims

1. A traditional Chinese medicine composition for treating thyroid nodules, characterized in that, The traditional Chinese medicine composition comprises the following raw materials in parts by weight: buckwheat: 150-250 parts, Panax notoginseng: 50-150 parts, Podophyllum hexandrum: 50-150 parts, Spatholobus suberectus: 150-250 parts, Cyperus rotundus: 100-200 parts, Armadillidium vulgare: 50-150 parts, Paederia scandens: 150-300 parts, and black ants: 50-150 parts.

2. The traditional Chinese medicine composition for treating thyroid nodules according to claim 1, characterized in that, The traditional Chinese medicine composition comprises the following raw materials in parts by weight: buckwheat: 245 parts, Panax notoginseng: 125 parts, Podophyllum hexandrum: 125 parts, Spatholobus suberectus: 110 parts, Cyperus rotundus: 110 parts, Armadillidium vulgare: 85 parts, Paederia scandens: 110 parts, and black ants: 85 parts.

3. The traditional Chinese medicine composition for treating thyroid nodules according to claim 1, characterized in that: In the aforementioned traditional Chinese medicine composition, the roots and leaves of buckwheat are used together.

4. The traditional Chinese medicine composition for treating thyroid nodules according to claim 1, characterized in that: The traditional Chinese medicine composition is prepared into capsules for later use.

5. The traditional Chinese medicine composition for treating thyroid nodules according to claim 4, characterized in that: The method for preparing the capsules includes the following steps: (1) Preparation of medicinal slices: Five-spice vine, chicken dung vine, buckwheat, Da Hong Pao, Bupleurum, Panax notoginseng, Cyperus rotundus and Podophyllum hexandrum were selected, washed, cut and dried to obtain medicinal slices of five-spice vine, chicken dung vine, buckwheat, Da Hong Pao, Bupleurum, Panax notoginseng, Cyperus rotundus and Podophyllum hexandrum. (2) Preparation of thick extract: Mix the sliced ​​herbs of five-spice vine, chicken dung vine, buckwheat, Da Hong Pao, and Bupleurum, add 6-8 times the amount of water of the total amount of herbs and soak for 1.0-2.0 hours, decoct for 1.5-2.5 hours, filter to obtain filtrate, add 4-6 times the amount of water of the total amount of herbs and decoct a second time for 1.5-2 hours, filter to obtain filtrate, discard the filter residue and combine the filtrate, heat and concentrate to obtain thick extract; (3) Grinding: The sliced ​​Panax notoginseng, sliced ​​Cyperus rotundus, and sliced ​​Podophyllum hexandrum were crushed and sieved to obtain fine powder of Panax notoginseng, fine powder of Cyperus rotundus, and fine powder of Podophyllum hexandrum; the woodlice and black ants were selected, crushed, sieved and sterilized to obtain fine powder of woodlice and fine powder of black ants. (4) Mixing and granulation: The thick extract is mixed with Panax notoginseng powder, Cyperus rotundus powder, Podophyllum hexandrum powder, Armadillidium vulgare powder and black ant powder, moistened with 85% ethanol, granulated, dried at 60-70℃, granulated, filled into capsules, and packaged to obtain capsules.

6. The traditional Chinese medicine composition for treating thyroid nodules according to claim 5, characterized in that: The capsules are available in a specification of 1.6g / capsule.

7. The traditional Chinese medicine composition for treating thyroid nodules according to claim 4, characterized in that: The dosage and administration of the capsules are as follows: 1.6g each time, 3 times a day, for 30 consecutive days as one course of treatment.

8. The traditional Chinese medicine composition for treating thyroid nodules according to claim 1, characterized in that, The traditional Chinese medicine composition is effective for thyroid nodules and pulmonary nodules.

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