Binary compound insecticidal composition containing niclosamide and metaldehyde

Abstract

The invention relates to the field of agricultural chemistry, in particular to a binary compound insecticidal composition containing niclosamide and metaldehyde, which is used for solving the problems that the traditional single-component insecticide can cause drug resistance of pests after being used for a long time, so that the control effect is reduced, certain limitation exists, and the use cost is low. The effect is not obvious when facing other types of pests, so that the negative influence on the environment is caused; according to the insecticidal composition, the niclosamide and the metaldehyde are compounded to form dual attacks, the dual attacks act on a nervous system and a respiratory system respectively, the lethal speed is remarkably increased, binary compounding of the niclosamide and the metaldehyde has a remarkable synergistic interaction effect, the defect that a single component is insufficient in insecticidal effect on pests under special environmental conditions is overcome, and the insecticidal effect is good. The control effect is improved, the dosage is reduced, and the development of drug resistance is delayed.

Description

Technical Field

[0001] This invention relates to the field of agricultural chemistry, specifically to a binary compound insecticide composition containing molluscicide and metaldehyde. Background Technology

[0002] In the field of agricultural chemistry, the damage of crops to pests is a long-standing problem. Although traditional single-component insecticides have a certain effect on pests in the short term, long-term use will lead to the development of pesticide resistance in pests and have a negative impact on the environment. Therefore, the development of new and highly effective insecticidal compositions has become the focus of research.

[0003] Spirochloride, as a highly effective insecticide, has excellent effects in controlling pests such as aquatic mollusks and has been widely used in the agricultural field. However, although spirochloride exhibits good insecticidal performance, it still has certain limitations when used alone. For example, it is not very effective against other types of pests. In addition, the use of spirochloride alone may lead to a certain degree of resistance in pests, which limits its long-term effectiveness.

[0004] By combining two or more components with complementary chemical properties and mechanisms of action, insecticidal effects can be improved, pest resistance can be reduced, and environmental impact can be minimized. Therefore, developing a binary compound insecticidal composition containing molluscicide and metaldehyde is of great significance. Summary of the Invention

[0005] In order to overcome the above-mentioned technical problems, the present invention aims to provide a binary compound insecticidal composition containing molluscicide and metaldehyde and its application, which solves the problem that long-term use of existing traditional single-component insecticides will lead to the development of pesticide resistance in pests and have a negative impact on the environment.

[0006] The objective of this invention can be achieved through the following technical solutions:

[0007] In a first aspect, the present invention provides a binary compound insecticidal composition containing molluscicide and metaldehyde, comprising 5-70% by weight of active ingredient, with the remainder being excipients;

[0008] The active ingredients include a first active ingredient and a second active ingredient;

[0009] The first active ingredient is molluscicide;

[0010] The second active ingredient is metaldehyde;

[0011] The mass ratio of the first active ingredient to the second active ingredient is (10-60):(1-30).

[0012] As a further aspect of the present invention: the mass ratio of the first effective component to the second effective component is (20-40):(5-20).

[0013] As a further aspect of the present invention, the mass ratio of the first effective component to the second effective component is 40:20.

[0014] As a further aspect of the present invention, the formulation of the insecticidal composition includes, but is not limited to, wettable powder, suspension concentrate, granules, and emulsion.

[0015] As a further aspect of the present invention: the insecticidal composition is a wettable powder, wherein the excipients in the wettable powder include a dispersant, a wetting agent, an antiflocculating agent, a stabilizer, and a filler; the dispersant is one of dispersant SD-891, dispersant HY-2700S, dispersant T-36, dispersant SD-661, tea saponin, and a separating agent; the wetting agent is one of wetting agent K12, wetting agent EFW, and wetting agent wet-88; the antiflocculating agent is sodium tripolyphosphate; the stabilizer is activated carbon; and the filler is one of kaolin, diatomaceous earth, silica, and corn starch.

[0016] As a further aspect of the present invention: the insecticidal composition is a suspension concentrate, wherein the excipients in the suspension concentrate include a dispersant, a wetting agent, a thickener, an antifreeze agent, a defoamer, a preservative, and deionized water; the dispersant is one of sodium lignosulfonate, sodium polycarboxylate DP5040, dispersant MorwetD400, and dispersant MorwetD500; the wetting agent is one of sodium dodecylbenzenesulfonate and agricultural emulsion 2000; the thickener is one of xanthan gum and carboxymethyl cellulose; the antifreeze agent is one of ethylene glycol and propylene glycol; the defoamer is defoamer AT-930; and the preservative is Kathon.

[0017] As a further aspect of the present invention: the insecticidal composition is a granule, wherein the excipients in the granule include a binder, a disintegrant, a surfactant, a stabilizer, an attractant, and a carrier; the binder is one of sodium carboxymethyl cellulose, starch, paraffin wax, and polyethylene glycol PEG-600; the disintegrant is one of ammonium sulfate and silica; the surfactant is one of sodium dodecylbenzene sulfonate and betaine; the stabilizer is silica; the attractant is one of fish meal and honey; and the carrier is one of bentonite and diatomaceous earth.

[0018] Secondly, the present invention provides the application of a binary compound insecticidal composition containing molluscicide and metaldehyde in the control of agricultural pests.

[0019] As a further aspect of the present invention, the pests include, but are not limited to, golden apple snails, oncomelania, snails, slugs, and small borers.

[0020] The beneficial effects of this invention are:

[0021] This invention discloses a binary insecticidal composition containing molluscicide and metaldehyde. The combination of molluscicide and metaldehyde creates a dual attack, acting on the nervous and respiratory systems respectively, significantly increasing the lethal rate. The binary combination of molluscicide and metaldehyde exhibits a significant synergistic effect, overcoming the limitations of single-component insecticidal effects under specific environmental conditions and on specific pests, improving control efficacy, reducing dosage, and delaying the development of resistance. Molluscicide is a respiratory toxin that inhibits the oxidative phosphorylation process in mitochondria of mollusks, interfering with energy production and causing paralysis and suffocation death in pests. Metaldehyde has a strong attraction to snails and slugs, acting on the nervous system of mollusks, stimulating them to secrete large amounts of mucus, leading to paralysis and death due to excessive dehydration. Metaldehyde provides a rapid knockdown effect, while molluscicide provides a longer residual effect. The combination of the two results in superior overall control efficacy. Due to the synergistic effect, the dosage of a single agent required to achieve the same control effect may be reduced, helping to lower costs and reduce environmental impact. Detailed Implementation

[0022] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0023] Example 1:

[0024] This embodiment describes a method for preparing a binary compound insecticide composition containing molluscicide and metaldehyde, comprising the following steps:

[0025] Weigh the following components according to the following mass ratio: 40% active ingredient, 7% dispersant, 10% wetting agent, 1% antiflocculation agent, 0.1% stabilizer, and filler to 100%; wherein the mass ratio of the active ingredient, molluscicide and metaldehyde, is 20:5; the dispersant is SD-891; the wetting agent is K12; the antiflocculation agent is sodium tripolyphosphate; the stabilizer is activated carbon; and the filler is kaolin.

[0026] The active ingredients, dispersant, wetting agent, antiflocculation agent, stabilizer and filler are mixed evenly and then pulverized by air jet to obtain a binary compound insecticide composition containing molluscicide and metaldehyde in the form of wettable powder.

[0027] Example 2:

[0028] This embodiment describes a method for preparing a binary compound insecticide composition containing molluscicide and metaldehyde, comprising the following steps:

[0029] Weigh the following components according to the following mass ratio: 45% active ingredient, 8% dispersant, 15% wetting agent, 2% antiflocculation agent, 2% stabilizer, and filler to 100%; wherein the mass ratio of the active ingredient, molluscicide and metaldehyde, is 25:5; the dispersant is SD-891; the wetting agent is K12; the antiflocculation agent is sodium tripolyphosphate; the stabilizer is activated carbon; and the filler is kaolin.

[0030] The active ingredients, dispersant, wetting agent, antiflocculation agent, stabilizer and filler are mixed evenly and then pulverized by air jet to obtain a binary compound insecticide composition containing molluscicide and metaldehyde in the form of wettable powder.

[0031] Example 3:

[0032] This embodiment describes a method for preparing a binary compound insecticide composition containing molluscicide and metaldehyde, comprising the following steps:

[0033] Weigh the following components according to the following mass ratio: 50% active ingredient, 10% dispersant, 20% wetting agent, 3% antiflocculation agent, 3% stabilizer, and filler to 100%; wherein the mass ratio of the active ingredient, molluscicide and metaldehyde, is 40:20; the dispersant is SD-891; the wetting agent is K12; the antiflocculation agent is sodium tripolyphosphate; the stabilizer is activated carbon; and the filler is kaolin.

[0034] The active ingredients, dispersant, wetting agent, antiflocculation agent, stabilizer and filler are mixed evenly and then pulverized by air jet to obtain a binary compound insecticide composition containing molluscicide and metaldehyde in the form of wettable powder.

[0035] Example 4:

[0036] This embodiment describes a method for preparing a binary compound insecticide composition containing molluscicide and metaldehyde, comprising the following steps:

[0037] Weigh the following components according to the following mass ratio: 25% active ingredient, 3% dispersant, 1% wetting agent, 0.1% thickener, 3% antifreeze agent, 0.1% defoamer, 0.1% preservative, and deionized water to bring the total to 100%; wherein, the mass ratio of molluscicide and metaldehyde in the active ingredient is 20:5; the dispersant is sodium lignosulfonate; the wetting agent is sodium dodecylbenzenesulfonate; the thickener is xanthan gum; the antifreeze agent is ethylene glycol; the defoamer is defoamer AT-930; and the preservative is Kathon.

[0038] The active ingredients, dispersant, wetting agent, thickener, antifreeze, defoamer, preservative and deionized water are mixed evenly and ground in a sand mill to obtain a binary compound insecticide composition containing molluscicide and metaldehyde in the form of a suspension.

[0039] Example 5:

[0040] This embodiment describes a method for preparing a binary compound insecticide composition containing molluscicide and metaldehyde, comprising the following steps:

[0041] Weigh the following components according to the following mass ratio: 35% active ingredient, 10% dispersant, 5% wetting agent, 1% thickener, 4% antifreeze agent, 0.5% defoamer, 0.4% preservative, and deionized water to bring the total to 100%; wherein, the mass ratio of molluscicide and metaldehyde in the active ingredient is 25:5; the dispersant is sodium lignosulfonate; the wetting agent is sodium dodecylbenzenesulfonate; the thickener is xanthan gum; the antifreeze agent is ethylene glycol; the defoamer is defoamer AT-930; and the preservative is Kathon.

[0042] The active ingredients, dispersant, wetting agent, thickener, antifreeze, defoamer, preservative and deionized water are mixed evenly and ground in a sand mill to obtain a binary compound insecticide composition containing molluscicide and metaldehyde in the form of a suspension.

[0043] Example 6:

[0044] This embodiment describes a method for preparing a binary compound insecticide composition containing molluscicide and metaldehyde, comprising the following steps:

[0045] Weigh the following components according to the following mass ratio: 45% active ingredient, 15% dispersant, 10% wetting agent, 2% thickener, 5% antifreeze, 1% defoamer, 0.5% preservative, and make up to 100% with deionized water; wherein, the mass ratio of molluscicide and metaldehyde in the active ingredient is 40:20; the dispersant is sodium lignosulfonate; the wetting agent is sodium dodecylbenzenesulfonate; the thickener is xanthan gum; the antifreeze is ethylene glycol; the defoamer is defoamer AT-930; and the preservative is Kathon.

[0046] The active ingredients, dispersant, wetting agent, thickener, antifreeze, defoamer, preservative and deionized water are mixed evenly and ground in a sand mill to obtain a binary compound insecticide composition containing molluscicide and metaldehyde in the form of a suspension.

[0047] Example 7:

[0048] This embodiment describes a method for preparing a binary compound insecticide composition containing molluscicide and metaldehyde, comprising the following steps:

[0049] The following components are weighed according to the following mass ratio: 5% active ingredient, 1% binder, 1% disintegrant, 0.5% surfactant, 1% stabilizer, 1% attractant, and carrier to 100%; wherein, the mass ratio of molluscicide and metaldehyde in the active ingredient is 20:5; the binder is sodium carboxymethyl cellulose; the disintegrant is ammonium sulfate; the surfactant is sodium dodecylbenzene sulfonate; the stabilizer is silica; the attractant is fish meal; and the carrier is diatomaceous earth.

[0050] The active ingredients, binder, disintegrant, surfactant, stabilizer, attractant and carrier are mixed evenly, pulverized by air jet mill and dried to obtain a binary compound insecticide composition containing molluscicide and metaldehyde in granule form.

[0051] Example 8:

[0052] This embodiment describes a method for preparing a binary compound insecticide composition containing molluscicide and metaldehyde, comprising the following steps:

[0053] The following components are weighed according to the following mass ratio: 10% active ingredient, 3% binder, 4% disintegrant, 3% surfactant, 2% stabilizer, 5% attractant, and carrier to bring the total to 100%; wherein, the mass ratio of molluscicide to metaldehyde in the active ingredient is 25:5; the binder is sodium carboxymethyl cellulose; the disintegrant is ammonium sulfate; the surfactant is sodium dodecylbenzene sulfonate; the stabilizer is silica; the attractant is fish meal; and the carrier is diatomaceous earth.

[0054] The active ingredients, binder, disintegrant, surfactant, stabilizer, attractant and carrier are mixed evenly, pulverized by air jet mill and dried to obtain a binary compound insecticide composition containing molluscicide and metaldehyde in granule form.

[0055] Example 9:

[0056] This embodiment describes a method for preparing a binary compound insecticide composition containing molluscicide and metaldehyde, comprising the following steps:

[0057] The following components are weighed according to the following mass ratio: 20% active ingredient, 4% binder, 8% disintegrant, 5% surfactant, 3% stabilizer, 10% attractant, and carrier to bring the total to 100%; wherein, the mass ratio of molluscicide to metaldehyde in the active ingredient is 40:20; the binder is sodium carboxymethyl cellulose; the disintegrant is ammonium sulfate; the surfactant is sodium dodecylbenzene sulfonate; the stabilizer is silica; the attractant is fish meal; and the carrier is diatomaceous earth.

[0058] The active ingredients, binder, disintegrant, surfactant, stabilizer, attractant and carrier are mixed evenly, pulverized by air jet mill and dried to obtain a binary compound insecticide composition containing molluscicide and metaldehyde in granule form.

[0059] Comparative Example 1:

[0060] This comparative example illustrates a method for preparing an insecticidal composition containing molluscicide, comprising the following steps:

[0061] Weigh the following components according to the following mass ratio: 35% active ingredient, 10% dispersant, 5% wetting agent, 1% thickener, 4% antifreeze agent, 0.5% defoamer, 0.4% preservative, and deionized water to bring the total to 100%; wherein, the active ingredient is molluscicide; the dispersant is sodium lignosulfonate; the wetting agent is sodium dodecylbenzenesulfonate; the thickener is xanthan gum; the antifreeze agent is ethylene glycol; the defoamer is defoamer AT-930; and the preservative is Kathon.

[0062] The active ingredient, dispersant, wetting agent, thickener, antifreeze, defoamer, preservative and deionized water are mixed evenly and ground in a sand mill to obtain an insecticidal composition containing molluscicide in the form of a suspension.

[0063] Comparative Example 2:

[0064] This comparative example illustrates a method for preparing an insecticidal composition containing metaldehyde, comprising the following steps:

[0065] Weigh the following components according to the following mass ratio: 35% active ingredient, 10% dispersant, 5% wetting agent, 1% thickener, 4% antifreeze agent, 5% defoamer, 0.4% preservative, and make up to 100% with deionized water; wherein, the active ingredient is metaldehyde; the dispersant is sodium lignosulfonate; the wetting agent is sodium dodecylbenzenesulfonate; the thickener is xanthan gum; the antifreeze agent is ethylene glycol; the defoamer is defoamer AT-930; and the preservative is Kathon.

[0066] The active ingredient, dispersant, wetting agent, thickener, antifreeze, defoamer, preservative and deionized water are mixed evenly and ground in a sand mill to obtain an insecticidal composition containing tetraacetaldehyde in the form of a suspension.

[0067] The insecticidal compositions of Examples 1-9 and Comparative Examples 1-2 were tested for their insecticidal effects according to the "Field Efficacy Test Guidelines (II) Part 81: Control of Rice Golden Apple Snails with Molluscicides"; the test target was rice golden apple snails; the field trials were conducted during the main occurrence season, and the cultivation conditions (such as soil type, fertilizer and water management, tillage conditions, etc.) of all test plots were uniform. The paddy fields should be kept at a water depth of 3-5 cm, and the water retention time should be the same as the time of the last survey. The plot treatments of the test agents and control agents were arranged in a randomized block design, replicated 4 times. The plots were enclosed with nets 80 cm high and small ridges were built for independent irrigation and drainage to prevent water cross-contamination, and a walkway was provided; the plot area was 20 m². 2 Before releasing the snails, plant 25 rice clumps per square meter, with 4 plants per clump. One week after planting, release the snails. Collect live snails of similar size (medium or large) [medium snails are 2.0-2.5 cm in height (from mouth to top) and large snails are 2.6 cm or more] and pre-culture them for at least 48 hours. Release 10 snails per square meter, with evenly distributed sizes, and gently place them evenly on the soil surface during release. Dissolve the insecticide composition in the mixing tank and spray it evenly in the experimental area using a backpack motorized sprayer, using 1 L of water per square meter. 2 The effective dose of the drug is 0.5 g / m². 2 ; Investigate the mortality rate 7 days after drug administration. During the investigation, identify all released snails and check the number of live and dead snails (if the number is less than the original number, it is counted as escape).

[0068] Use the SAS statistical analysis system to find the regression equation and calculate LC. 50 The co-toxicity factor was calculated using the method proposed by Mansour: Co-toxicity factor = (Morbidity rate of the mixture - Expected mortality rate of the mixture) / Expected mortality rate of the mixture × 100; a co-toxicity factor above +20 indicates a synergistic effect, below -20 indicates an antagonistic effect, and between -20 and +20 indicates an additive effect; the mortality rate of the mixture was obtained by directly treating pests with a single dose or concentration of the mixture, decomposing the dose or concentration of the mixture according to the mixing ratio, and then calculating the mortality rates of the corresponding single agents from the regression equations of each single agent, and summing them up to obtain the expected mortality rate of the mixture;

[0069] The test results are shown in the table below:

[0070]

[0071]

[0072] Referring to the table above, based on the comparison between Examples 1-9 and Comparative Examples 1-2, it can be seen that the insecticidal effect of the binary compound insecticidal composition of spirochloride and metaldehyde on golden apple snails in rice is significantly greater than that of the single composition. The co-toxicity factor is above +20, indicating that the compound of spirochloride and metaldehyde has a synergistic effect.

[0073] In the description of this specification, references to terms such as "an embodiment," "example," "specific example," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the invention. In this specification, illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0074] The above description is merely an example and illustration of the present invention. Those skilled in the art can make various modifications or additions to the specific embodiments described or use similar methods to replace them, as long as they do not deviate from the invention or exceed the scope defined in this application, they should all fall within the protection scope of the present invention.

Claims

1. A binary compound insecticidal composition containing molluscicide and metaldehyde, characterized in that, It contains 5-70% active ingredients by weight, with the remainder being excipients; The active ingredients include a first active ingredient and a second active ingredient; The first active ingredient is molluscicide; The second active ingredient is metaldehyde; The mass ratio of the first active ingredient to the second active ingredient is (10-60):(1-30).

2. The insecticidal composition containing molluscicide and metaldehyde according to claim 1, characterized in that, The mass ratio of the first active ingredient to the second active ingredient is (20-40):(5-20).

3. The insecticidal composition containing molluscicide and metaldehyde according to claim 2, characterized in that, The mass ratio of the first active ingredient to the second active ingredient is 40:

20.

4. The insecticidal composition containing molluscicide and metaldehyde according to claim 1, characterized in that, The formulations of the insecticidal composition include wettable powder, suspension concentrate, granules, and emulsion.

5. The binary compound insecticidal composition containing molluscicide and metaldehyde according to claim 4, characterized in that, The insecticidal composition is a wettable powder, and the excipients in the wettable powder include dispersants, wetting agents, antiflocculation agents, stabilizers, and fillers; the dispersant is one of dispersant SD-891, dispersant HY-2700S, dispersant T-36, dispersant SD-661, tea saponin, and a spreading agent; the wetting agent is one of wetting agent K12, wetting agent EFW, and wetting agent wet-88; the antiflocculation agent is sodium tripolyphosphate; the stabilizer is activated carbon; and the filler is one of kaolin, diatomaceous earth, silica, and corn starch.

6. The insecticidal composition containing molluscicide and metaldehyde according to claim 4, characterized in that, The insecticidal composition is a suspension concentrate, and the excipients in the suspension concentrate include a dispersant, a wetting agent, a thickener, an antifreeze agent, a defoamer, a preservative, and deionized water; the dispersant is one of sodium lignosulfonate, sodium polycarboxylate DP5040, dispersant MorwetD400, and dispersant MorwetD500; the wetting agent is one of sodium dodecylbenzenesulfonate and agricultural emulsion 2000; the thickener is one of xanthan gum and carboxymethyl cellulose; the antifreeze agent is one of ethylene glycol and propylene glycol; the defoamer is defoamer AT-930; and the preservative is Kathon.

7. The binary compound insecticidal composition containing molluscicide and metaldehyde according to claim 4, characterized in that, The insecticidal composition is a granule formulation, wherein the excipients in the granule formulation include a binder, a disintegrant, a surfactant, a stabilizer, an attractant, and a carrier; the binder is one of sodium carboxymethyl cellulose, starch, paraffin wax, and polyethylene glycol PEG-600; the disintegrant is one of ammonium sulfate and silica; the surfactant is one of sodium dodecylbenzene sulfonate and betaine; the stabilizer is silica; the attractant is one of fish meal and honey; and the carrier is one of bentonite and diatomaceous earth.

8. The application of the binary compound insecticidal composition containing molluscicide and metaldehyde according to claim 1 in the control of agricultural pests.

9. The application of the binary compound insecticidal composition containing molluscicide and metaldehyde according to claim 8 in the control of agricultural pests, characterized in that, The pests include golden apple snails, oncomelania snails, snails, slugs, and small borer snails.

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