Gas sampling system and medical gas transmission system

Abstract

The invention provides a gas sampling system and a medical gas transmission system, and relates to the field of sampling monitoring equipment. The gas sampling system comprises a sampling pipe, one end of the sampling pipe is communicated with an inspiration branch of a mechanical ventilation loop, the other end of the sampling pipe is communicated with a gas detection system, and nitric oxide gas is injected into the inspiration branch; the sampling pipe is used for leading gas containing nitric oxide in the gas suction branch to the gas detection system; at least one part of the sampling pipe is a water vapor permeable section, and the pipe wall of the water vapor permeable section is made of a water vapor permeable material; water content is reduced after gas passes through the sampling pipe. The gas sampling system provided by the invention solves the technical problems of inconvenience in use caused by frequent water pouring of a water collection cup or infection risk caused by bacterium breeding caused by long-time water collection of a large-capacity appliance in the prior art.

Description

Technical Field

[0001] This application relates to the field of sampling and monitoring equipment, and more specifically, to a gas sampling system and a medical gas transmission system. Background Technology

[0002] In mechanical ventilation therapy, it is usually necessary to collect and detect specific parameters in the ventilation gas to determine the quality of ventilation or its potential impact on the patient. In this process, a sampling line is usually used to collect a portion of the gas in the ventilation circuit and transmit it to a gas monitoring device for monitoring.

[0003] Since the ventilation gas needs to be introduced into the patient's lungs, the ventilation gas is a high-humidity gas. Currently, gas sampling and monitoring equipment on the market uses a sampling tube and a water collection cup for dehumidification. The high-humidity sample gas flows into the water collection cup through the sampling tube, and the liquid water droplets are blocked by the hydrophobic membrane inside the water collection cup and collected in the water collection cup. When the water collection cup is full, medical staff need to pour out the water. Frequent pouring of water increases the workload of medical staff and also creates a bad user experience.

[0004] Existing technologies involve adding a pump to the gas sampling and monitoring equipment to periodically pump the water from the collection cup into another large-capacity container, reducing the frequency of water emptying. However, there is a problem that long-term water storage in the large-capacity container can lead to the growth and reproduction of bacteria or viruses, posing health risks to patients and medical staff. Summary of the Invention

[0005] The purpose of this application is to provide a gas sampling system and a medical gas transmission system to alleviate the technical problems in the prior art, such as the inconvenience caused by the need to frequently empty the water collection cup, or the risk of infection caused by bacterial growth due to long-term water collection in large-capacity devices.

[0006] To solve the above-mentioned technical problems, the technical solution provided by the present invention is as follows: In a first aspect, the gas sampling system provided by the present invention includes a sampling tube; One end of the sampling tube is used to connect to the intake branch of the mechanical ventilation circuit, and the other end is used to connect to the gas detection system. Nitric oxide gas is injected into the intake branch. The sampling tube is used to pass the nitric oxide-containing gas in the intake branch to the gas detection system; At least a portion of the sampling tube is a water vapor permeable section, and the wall of the water vapor permeable section is made of a water vapor permeable material; The gas loses moisture content after passing through the sampling tube.

[0007] Furthermore, the moisture absorption rate of the water vapor permeable material is greater than 1%.

[0008] Furthermore, the water vapor permeable material includes one or more of the following: cellulose derivative materials, chitin derivative materials, polyvinyl alcohol and modified materials, amide group-containing materials, and water-absorbing resin materials.

[0009] Furthermore, the water vapor permeable material includes one or more of carboxymethyl cellulose, CA, CP, chitosan, polyvinyl alcohol, polyethylene glycol, polybutylene glycol, polyacrylic acid, perfluorosulfonic acid, PA6, PA11, PA12, PA46, PA66, PESU, PI, sodium polyacrylate, and EVOH.

[0010] Furthermore, the concentration of nitric oxide in the gas decreases by ≤2 ppm after passing through the sampling tube.

[0011] Furthermore, the total length of the water vapor permeable section is greater than or equal to 20 centimeters; The total length of the water vapor permeable section is set to be more than 10% of the total length of the sampling tube.

[0012] Furthermore, the inner diameter of the sampling tube is set to 1-5 mm.

[0013] Furthermore, the entire sampling tube is configured as a water vapor permeable section.

[0014] Furthermore, connector assemblies are installed at both ends of the water vapor permeable section.

[0015] Furthermore, the connector assembly includes a connector body and a limiting sleeve. The end of the water vapor permeable section is connected to the connector body, the limiting sleeve is fixedly connected to the connector body, and the limiting sleeve surrounds the outer periphery of the end of the water vapor permeable section.

[0016] Furthermore, the gas sampling system also includes a safety component connected between the sampling tube and the gas detection system.

[0017] Furthermore, the safety component includes an air inlet, a housing, a waterproof membrane, and an air outlet; The air intake component is provided with an air inlet, which is connected to the sampling tube; Along the gas flow direction, the air inlet, the container, the water-proof membrane, and the air outlet are connected in sequence.

[0018] In a second aspect, the medical gas transmission system provided by the present invention includes a nitric oxide generator, a gas detection system, a three-way connector, and a gas sampling system as described in any of the above. The gas output end of the nitric oxide generator is used to connect to the intake branch of the mechanical ventilation circuit; The three-way connector is installed in the intake branch along the gas flow direction, and the three-way connector is located downstream of the connection between the gas output end and the intake branch; In the gas sampling system, one end of the sampling tube is connected to the three-way connector, and the other end is connected to the gas detection system; The gas detection system is used to detect at least the concentration of nitric oxide in the gas transmitted via the gas sampling system.

[0019] Based on the above technical solutions, the technical effects achievable by this invention can be analyzed as follows: The gas sampling system provided by this invention includes a sampling tube; one end of the sampling tube is used to connect to the intake branch of a mechanical ventilation circuit, and the other end is used to connect to a gas detection system, wherein nitric oxide gas is injected into the intake branch; the sampling tube is used to pass the nitric oxide-containing gas in the intake branch to the gas detection system; at least a portion of the sampling tube is a water vapor permeable section, and the wall of the water vapor permeable section is made of a water vapor permeable material; the gas reduces its water content after passing through the sampling tube.

[0020] The requirement that at least a portion of the sampling tube is a water-permeable section means that at least a portion of the tube wall is made of a water-permeable material. For example, at least one-third of the tube wall may be made of this material; or at least half may be made of it; or the entire tube wall may be made of this material. The function of the water-permeable section is to reduce the water content of the gas as it flows through the sampling tube.

[0021] In this nitric oxide mechanical ventilation treatment scenario, the sampling tube is used to deliver nitric oxide-containing gas from the inspiratory branch of the mechanical ventilation circuit to the gas detection system. When the high-humidity gas passes through the sampling tube, it condenses on the tube wall and is then absorbed by the water-permeable material, evaporating into the surrounding environment through the tube wall thickness. This reduces the humidity of the sample gas reaching the water collection cup, thereby reducing the water removal pressure and avoiding the burden of frequent water emptying. Furthermore, if the water-permeable section is long enough, the water collection cup can be eliminated, completely eliminating the need for water emptying. It is worth noting that the sample gas introduced into the sampling tube is a high-humidity sample gas, with a humidity level far exceeding the ambient humidity. Attached Figure Description

[0022] To more clearly illustrate the technical solutions of the embodiments of this application, the accompanying drawings used in the embodiments of this application will be briefly introduced below. It should be understood that the following drawings only show some embodiments of this application and should not be regarded as a limitation of the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0023] Figure 1This is a schematic diagram of the gas sampling system provided in the embodiments of this application from a first-view perspective; Figure 2 This is a schematic diagram of the gas sampling system provided in the embodiments of this application from a second perspective; Figure 3 This is a schematic diagram of the connector assembly in the gas sampling system provided in the embodiments of this application; Figure 4 This is a schematic diagram of the gas sampling system provided in an embodiment of this application; Figure 5 This is a schematic diagram of the structure of the safety component in the gas sampling system provided in the embodiments of this application; Figure 6 Schematic diagram of the structure of the medical gas delivery system provided in the embodiments of this application Figure 1 ; Figure 7 Schematic diagram of the structure of the medical gas delivery system provided in the embodiments of this application Figure 2 .

[0024] icon: 1-Sampling tube; 10-Water vapor permeable section; 2-Connector assembly; 21-Connector body; 22-Limiting sleeve; 3-Safety component; 31-Inlet component; 311-Inlet port; 32-Container component; 33-Waterproof membrane; 34-Outlet component; 341-Outlet port; 4-Nitric oxide generator; 5-Gas detection system; 6-Mechanical ventilation circuit; 61-Intake branch; 62-T-connector; 7-Humidifier. Detailed Implementation

[0025] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. The components of the embodiments of this application described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0026] In the description of this application, it should be noted that the terms "inner" and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship commonly used when the product is in use. They are used only for the convenience of describing this application and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application. Furthermore, the terms "first," "second," etc., are used only to distinguish descriptions and should not be construed as indicating or implying relative importance.

[0027] In the description of this application, it should also be noted that, unless otherwise expressly specified and limited, the terms "setup" and "connection" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.

[0028] Example 1 Since the ventilation gas is introduced into the patient's lungs, it is usually a high-humidity gas. Currently, gas sampling and monitoring devices on the market typically use a sampling tube and a water collection cup for dehumidification. The high-humidity sample gas flows into the water collection cup through the sampling tube, and the small liquid water droplets are blocked by the hydrophobic membrane inside the water collection cup and collected in the water collection cup. When the water collection cup is full, medical staff need to empty the water. Frequent emptying of the water increases the workload of medical staff and also creates a poor user experience. Some products have made improvements to this, such as adding a pump to the device to periodically pump the water in the water collection cup to another large-capacity device, which can ensure that the water does not need to be emptied for a long time. However, this design has drawbacks. Because some sampling and monitoring occur in ICU wards, patients have various diseases. If the large-capacity device is not emptied for a long time, bacteria or viruses will grow and multiply in the large-capacity device, which will pose health risks to patients and medical staff.

[0029] Specifically, in nitric oxide inhalation therapy, nitric oxide gas is typically injected into the inspiratory circuit of a mechanical ventilation device (such as a ventilator), humidified by a humidifier, and then delivered to the patient's lungs as a highly humidified gas. During this process, medical staff usually need to understand the composition of the ventilation gas that is about to be delivered to the patient's lungs, such as the levels of nitric oxide, nitrogen dioxide, and oxygen. Therefore, it is necessary to monitor the composition of the gas as close as possible to the patient's location (because the data obtained in this way will be closer to the data of the gas entering the patient's lungs) in order to facilitate medical judgment.

[0030] In view of this, see Figure 1 and Figure 3The gas sampling system provided in this embodiment of the invention includes a sampling tube 1; one end of the sampling tube 1 is used to connect to the intake branch of the mechanical ventilation circuit, and the other end is used to connect to the gas detection system, wherein nitric oxide gas is injected into the intake branch; the sampling tube 1 is used to pass the nitric oxide-containing gas in the intake branch to the gas detection system; at least a portion of the sampling tube 1 is a water vapor permeable section 10, and the wall of the water vapor permeable section 10 is made of a water vapor permeable material; the gas reduces its water content after passing through the sampling tube 1.

[0031] Specifically, sampling tube 1 is formed by an extrusion process.

[0032] The phrase "at least a portion of the sampling tube 1 is a water-permeable section 10" means that at least a portion of the tube wall of the sampling tube 1 is made of a water-permeable material. For example, at least one-third of the tube wall of the sampling tube 1 is made of a water-permeable material; or, at least half of the tube wall of the sampling tube 1 is made of a water-permeable material; or, the entire tube wall of the sampling tube 1 is made of a water-permeable material. The function of the water-permeable section 10 is to reduce the water content after the gas flows through the sampling tube 1.

[0033] In the nitric oxide mechanical ventilation treatment scenario, sampling tube 1 is used to pass the gas in the mechanical ventilation circuit 6 to the gas detection system 5. When high-humidity gas passes through sampling tube 1, it condenses on the tube wall and is then absorbed by the water-permeable material, evaporating into the surrounding environment through the tube wall thickness. This reduces the humidity of the sample gas reaching the water collection cup, thereby reducing the dehumidification pressure and avoiding the burden of frequent water emptying. It is worth noting that the sample gas introduced into sampling tube 1 is high-humidity gas, with a humidity level far exceeding the ambient humidity. Furthermore, this gas sampling system can be used in nitric oxide mechanical ventilation treatment scenarios. By setting an appropriate length for the water-permeable material tube wall, it can effectively remove moisture from the sampled gas in the inhalation branch 61, thus replacing the function of the water collection cup in existing solutions. Dehumidification can be completed through sampling tube 1, eliminating the need for the water collection cup and completely solving the problem of water emptying. Furthermore, the gas sampling system has a simple structural design, requiring no complex hydrophobic or water-absorbing structures, resulting in lower production and processing costs and reducing the likelihood of clogging.

[0034] In the optional solutions provided in the embodiments of the present invention, the moisture absorption rate of the water vapor permeable material is greater than 1%.

[0035] The wall of the water vapor permeable section 10 is made of a water vapor permeable material with a moisture absorption rate of more than 1%, which reduces the water content of the gas after it flows through the sampling tube 1.

[0036] In the optional solutions provided in the embodiments of the present invention, the water vapor permeable material includes one or more of the following: cellulose derivative materials, chitin derivative materials, polyvinyl alcohol and modified materials, amide group-containing materials, and water-absorbing resin materials.

[0037] Examples include one or more of carboxymethyl cellulose, cellulose acetate (CA), cellulose propionate (CP), chitosan, polyvinyl alcohol (PVA), polyethylene glycol (PEG), polybutanediol (PTMG), polyacrylic acid (PAA), perfluorosulfonic acid (PFSA), polyamide 6 (PA6), polyundecylamide (PA11), polydodecyl lactam (PA12), polyadipamide (PA46), polyadipamide (PA66), polyethersulfone (PESU), polyimide (PI), sodium polyacrylate (ASAP), and ethylene-vinyl alcohol copolymer (EVOH). See Table 1 below, which shows (but is not exhaustive) some of the exemplary materials selected in this embodiment and their moisture absorption rates.

[0038] Table 1. Water vapor permeable materials and their moisture absorption rates

[0039] When a water vapor permeable material is set to have a moisture absorption rate greater than 1, it can achieve the effect of reducing gas humidity.

[0040] In the optional solution provided by the embodiments of the present invention, the water vapor permeable material will not react with nitric oxide, and the nitric oxide gas will not permeate out of the pipe wall through the water vapor permeable material.

[0041] Specifically, see Figure 6 and Figure 7 One end of the sampling tube 1 is connected to the intake branch 61 of the mechanical ventilation circuit 6. Nitric oxide gas is injected into the intake branch 61. The sampling tube 1 is used to pass the nitric oxide-containing gas in the intake branch 61 to the gas detection system 5.

[0042] When applied to mechanical ventilation for nitric oxide treatment, the water-permeable material does not react with NO, and NO gas does not permeate out of the tube wall through the water-permeable material. Therefore, the concentration of nitric oxide in the sampled gas does not decrease after passing through sampling tube 1.

[0043] In the optional solution provided by the embodiments of the present invention, the concentration of nitric oxide in the gas decreases by ≤2ppm after passing through sampling tube 1.

[0044] Specifically, the concentration reduction of nitric oxide in the gas after passing through sampling tube 1 is usually less than or equal to 2 ppm (the NO component in the sampling gas may react with components such as oxygen in the sampling gas, which may cause a decrease in NO concentration, but this is not caused by water vapor permeable materials); it will not affect the concentration of the component to be measured in the sample gas, thereby avoiding any impact on the detection results of the downstream gas detection system 5.

[0045] In the optional solution provided in the embodiments of the present invention, the total length of the water vapor permeable section 10 is greater than or equal to 20 centimeters.

[0046] Specifically, the length of the tube wall in sampling tube 1, made of a water vapor permeable material, is greater than or equal to 20 cm. In other words: First, at least a portion of sampling tube 1 being a water vapor permeable section 10 includes the following three cases: only a portion of sampling tube 1 is set as a water vapor permeable section 10; the entire sampling tube 1 is set as a water vapor permeable section 10; multiple portions of sampling tube 1 are set as water vapor permeable sections 10; then, when only a portion of sampling tube 1 is set as a water vapor permeable section 10, the length of the water vapor permeable section 10 is greater than or equal to 20 cm; when the entire sampling tube 1 is set as a water vapor permeable section 10, the overall length of sampling tube 1 is greater than or equal to 20 cm; when sampling tube 1 has multiple water vapor permeable sections 10, the cumulative length of the multiple water vapor permeable sections 10 is greater than or equal to 20 cm.

[0047] The total length of the water vapor permeable section 10 is greater than or equal to 20 cm, ensuring the effectiveness of the sampling tube 1 in reducing the humidity of the sample gas. Compared with the prior art, the sampling tube 1 in the prior art is only used to conduct the sampling gas, while the dehumidification task is completed by the downstream water collection cup. The water vapor in the sampling gas accumulates in the water collection cup, thus requiring frequent emptying. Moreover, bacteria can easily grow in the collected water, posing a risk of infection. If the water is not emptyed in time, it will affect the detection and the lifespan of the downstream detection system. This application can effectively remove water vapor from the sampling gas through the sampling tube 1, thereby replacing the original function of the water collection cup, solving the burden of frequent water emptying. At the same time, since a large amount of water vapor is removed when passing through the pipeline section, water accumulation is avoided, effectively reducing the risk of bacterial growth and protecting the health of patients and medical staff.

[0048] In the optional solution provided by the embodiments of the present invention, the proportion of the total length of the water vapor permeable section 10 to the total length of the sampling tube 1 is set to be more than 10%.

[0049] Specifically, in this embodiment, the total length of the water vapor permeable section 10 refers to: the length of the water vapor permeable section 10 when the sampling tube 1 has only one water vapor permeable section 10; and the sum of the lengths of the multiple water vapor permeable sections 10 when the sampling tube 1 has multiple water vapor permeable sections 10. Wherein, when all sampling tubes 1 are configured as water vapor permeable sections 10, there is only one water vapor permeable section 10, and the length of the water vapor permeable section 10 accounts for 100% of the length of the sampling tube 1, which is greater than 10%. In this embodiment, all of the sampling tubes 1 are configured as water vapor permeable sections 10. It is worth noting that: 10% or more means greater than or equal to 10%.

[0050] The length of the water vapor permeable section 10 in the sampling tube 1 is ≥10%, giving full play to the moisture absorption and dehumidification advantages of the water vapor permeable section 10. The tube wall of the conventional sampling tube 1 is usually made of PVC material, which can only play the role of transmitting sample gas. The water vapor in the sample gas cannot pass through the tube wall and be removed. The larger the length of the water vapor permeable section 10, the longer the dehumidification time of the sample gas water vapor, and thus the better the dehumidification effect.

[0051] In the optional solution provided in the embodiments of the present invention, the inner diameter of the sampling tube 1 is set to 1-5mm.

[0052] Specifically, the inner diameter of sampling tube 1 is set to 1-5mm. If the inner diameter of the water vapor permeable section 10 is too small, the air resistance of sampling tube 1 will be too large, which will place higher demands on the sample gas collection drive unit. It may also lead to insufficient sample gas volume, making it difficult for the detection unit downstream of sampling tube 1 to detect it. If the inner diameter of the water vapor permeable section 10 is too large, the sampling volume will be too large, which will affect the gas flow rate requirement in the normal passage. In addition, a large amount of sample gas will not be able to fully contact the tube wall, thereby reducing the dehumidification efficiency of the water vapor permeable section 10. Therefore, the inner diameter of the water vapor permeable section 10 is limited to a suitable range to ensure the optimal dehumidification effect.

[0053] In the optional solution provided by the embodiments of the present invention, connector assemblies 2 are installed at both ends of the water vapor permeable section 10.

[0054] Specifically, see Figures 1 to 3In this embodiment, the entire wall of the sampling tube 1 is made of a water-permeable material, and connector assemblies 2 are installed at both ends of the sampling tube 1. The connector assembly 2 includes a connector body 21 and a limiting sleeve 22. The end of the sampling tube 1 is connected to the connector body 21, and the limiting sleeve 22 is fixedly connected to the connector body 21, surrounding the outer periphery of the end of the sampling tube 1. Due to the hygroscopic properties of water-permeable materials, they tend to absorb water and swell when exposed to high-humidity gas for extended periods. Traditionally, pipes and connectors are fixed by direct adhesive bonding or by inserting the pipe end into the connector interface. However, in cases where the sampling tube 1 is made of a water-permeable material, especially when the end of the sampling tube 1 is also made of a water-permeable material, the swelling and hygroscopic nature of the material can cause the end of the pipe, fixed in a conventional way, to loosen from the connector. This can lead to interruptions in medical applications, affecting treatment. For this situation, see [link to relevant documentation]. Figure 3 The connector assembly 2 includes a connector body 21 and a limiting sleeve 22; the end of the water vapor permeable section 10 is connected to the connector body 21; the limiting sleeve 22 is fixedly connected to the connector body 21 and surrounds the outer side of the end pipe wall of the water vapor permeable section 10. Specifically, as follows... Figure 3 One end of the connector body 21 is a Luer connector, commonly used in medical piping connections, for connecting to a water collection cup or other piping interface that also has a Luer connector. The other end of the connector body 21 is a pagoda-shaped interface, which is inserted into the port of the water-permeable section 10. A limiting sleeve 22 is provided around the pagoda-shaped interface. Simultaneously, the limiting sleeve 22 is also fitted over the outer side of the port wall of the water-permeable section 10. Therefore, even if the wall material of the port of the water-permeable section 10 absorbs moisture and swells, the limiting sleeve 22 prevents it from falling off, ensuring the airtightness of the connection and preventing any impact on gas sampling and detection.

[0055] In the optional solution provided by the embodiments of the present invention, the entire sampling tube 1 is configured as a water vapor permeable section 10, and connector assemblies 2 are installed at both ends.

[0056] Specifically, the entire sampling tube 1 is a water vapor permeable section 10, maximizing the dehumidification effect. This allows it to replace the function of the water collection cup in existing solutions, enabling dehumidification solely through the sampling tube 1. This eliminates the need for the water collection cup, completely resolving the burden of emptying the water and the risk of bacterial growth in the collected water. The connector assemblies 2 at both ends of the sampling tube 1 are used for connection to other equipment pipelines.

[0057] In another embodiment, the sampling tube 1 includes a water vapor permeable section 10 and a normal section, which are connected by a connector assembly 2.

[0058] Specifically, the ordinary section is made of PVC. The sampling tube 1 includes a water vapor permeable section 10 and an ordinary section. Both ends of the water vapor permeable section 10 are equipped with connector assemblies 2. One connector assembly 2 connects to the ordinary section, and the other connector assembly 2 connects to other pipelines. Alternatively, both ends of the sampling tube 1 are water vapor permeable sections 10, with a single ordinary section in the middle. Both ends of the water vapor permeable section 10 are equipped with connector assemblies 2. Alternatively, both ends of the sampling tube 1 are water vapor permeable sections 10, and multiple ordinary sections are provided, with a water vapor permeable section 10 installed between adjacent ordinary sections. Alternatively, both ends of the sampling tube 1 are ordinary sections; there is one water vapor permeable section 10, and both ends are connected to the ordinary section via connector assemblies 2. Alternatively, both ends of the sampling tube 1 are ordinary sections; there are multiple water vapor permeable sections 10, and adjacent water vapor permeable sections 10 and ordinary sections are connected via connector assemblies 2.

[0059] The connector assembly 2 connects the water vapor permeable section 10 to the ordinary section, as well as to other pipelines. Of course, the use of connector assembly 2 to connect the ordinary section to other pipelines should also be within the scope of protection of this embodiment of the invention.

[0060] Among the optional solutions provided in the embodiments of the present invention, see [link to relevant documentation]. Figure 4 The gas sampling system also includes a safety component 3, which is connected between the sampling tube 1 and the gas detection system.

[0061] Specifically, when using this gas sampling system, the safety component 3 is located downstream of the sampling tube 1 along the gas flow direction. In some special cases (e.g., the sampling end of the sampling tube 1 is connected to the lowest point of the intake branch 61, where liquid water may accumulate), liquid water may be drawn from the sampling tube 1. The amount of liquid water may exceed the upper limit of the moisture absorption capacity of the water vapor permeable material tube wall. To address this, the safety component 3 is installed downstream of the sampling tube 1. The inlet 311 of the safety component 3 is connected to the end of the sampling tube 1, and the outlet 341 is connected to the gas detection system 5. The safety component 3 is used to intercept and collect any remaining water from the sampling tube 1.

[0062] By incorporating safety component 3, a double safety measure is added to the gas sampling system. When liquid is collected by sampling tube 1, safety component 3 effectively prevents the liquid from entering the downstream gas detection system 5, thus avoiding any impact on the lifespan and detection accuracy of the gas detection system 5. Compared with existing technologies, where sampling tube 1 is only used to conduct the sampling gas, and dehumidification is handled by the downstream water collection cup, water vapor in the sampling gas accumulates in the water collection cup, requiring frequent emptying. Furthermore, bacteria can easily grow in the collected water, posing an infection risk. Failure to empty the water in a timely manner can affect the detection and the lifespan of the downstream detection system. This gas sampling system effectively removes water vapor from the sampling gas through sampling tube 1, thus replacing the original water collection cup function and eliminating the burden of frequent emptying. Simultaneously, because a large amount of water vapor is removed as it passes through the pipeline, water accumulation is avoided, effectively reducing the risk of bacterial growth and protecting the health of patients and medical staff. Moreover, in the event of improper operation or special circumstances causing sampling tube 1 to inhale liquid, the safety component 3 provides double protection, effectively preventing any impact on the lifespan and detection accuracy of the gas detection system 5.

[0063] Among the optional solutions provided in the embodiments of the present invention, see [link to relevant documentation]. Figure 5 The safety component 3 includes an air inlet 31, a container 32, a water-proof membrane 33, and an air outlet 34; the air inlet 31 is provided with an air inlet 311, which is connected to the sampling tube 1; along the gas flow direction, the air inlet 31, the container 32, the water-proof membrane 33, and the air outlet 34 are connected in sequence.

[0064] Specifically, the air inlet 31 has an air inlet 311 that connects to the end of the sampling tube 1; the container 32 is located downstream of the air inlet 31 and is used to contain water vapor; the water-proof membrane 33 is located downstream of the container 32 and is used to block water vapor from passing through; the air outlet 34 is located downstream of the water-proof membrane 33 and has an air outlet 341 that connects to the gas detection system 5. For example, the container 32 is a cylindrical container with an open top, and the air inlet 31 is detachably fitted to the top of the container 32, for example, by means of a threaded connection. An air inlet channel is formed on the air inlet 31, with an air inlet 311 at one end, located on the side of the air inlet 31. The end of the air inlet 311 can be formed into a Luer connector to facilitate connection with the end of the sampling tube; an air outlet is formed at the other end of the air inlet channel, opening towards the container 32. A through hole is opened at the top of the air inlet 31, and a water-proof membrane 33 is placed above the through hole to seal it. The water-proof membrane 33 is made of a material with water-proof and air-permeable functions commonly used in the prior art, such as PTFE (polytetrafluoroethylene). Its characteristic is that it allows gas to pass through while blocking liquid from passing through. Therefore, in the fluid that enters the container 32 through the air inlet 311, only gas can pass through the water-proof membrane 33 to reach above it, while the liquid is blocked and left in the container 32. An air outlet 34 is arranged above the water-proof membrane 33. The air outlet 34 is connected to the air inlet 31, for example by snap-fit ​​or threaded connection. An air outlet channel is formed on the air outlet 34. An air outlet 341 is opened at one end of the air outlet channel. The air outlet 341 is located on the side of the air inlet 31 away from the air inlet 311. The end of the air outlet 341 can be formed into a quick plug to facilitate quick connection and disassembly with the gas detection system 5. An air outlet inlet is opened at the other end of the air outlet channel, which opens above the water-proof membrane 33.

[0065] Typically, gas detection systems have a driving force (e.g., provided by a pump installed in the system) to draw in sample gas. Under this driving force, the sample gas is drawn from the intake branch, passes through the sampling tube 1 and the safety assembly 3, and then enters the gas detection system. After entering the intake channel through the inlet 311 of the safety assembly 3, the sample gas enters the space of the container 32. Under the continuous drawing force, the sample gas in the container 32 flows through the water-proof membrane 33 towards the outlet channel. The liquid that has not been completely removed from the sampling tube 1 remains in the container 32 due to the obstruction of the water-proof membrane 33. Thus, only the gas is drawn into the gas detection system through the outlet 341.

[0066] Example 2 The medical gas transmission system provided in this embodiment of the invention includes the gas sampling system described in Embodiment 1, and therefore also possesses all the beneficial effects of Embodiment 1, which will not be repeated here.

[0067] Among the optional solutions provided in the embodiments of the present invention, see [link to relevant documentation]. Figure 6 and Figure 7 The medical gas delivery system includes a nitric oxide generator 4, a gas detection system 5, and a three-way connector 62. The gas output end of the nitric oxide generator 4 is used to connect to the intake branch 61 of the mechanical ventilation circuit 6. The three-way connector 62 is installed on the intake branch 61, and along the gas flow direction, the three-way connector 62 is located downstream of the connection between the gas output end and the intake branch 61. One end of the sampling tube 1 in the gas sampling system is connected to the three-way connector 62, and the other end is connected to the gas detection system 5. The gas detection system 5 is used to detect at least the concentration of nitric oxide in the gas transmitted via the gas sampling system.

[0068] Specifically, the nitric oxide generator 4 is used to output medical gas containing nitric oxide. The gas output end of the nitric oxide generator 4 is connected to the inhalation branch 61 of the mechanical ventilation circuit 6. A three-way connector 62 is installed on the inhalation branch 61 downstream of the connection between the gas output end and the inhalation branch 61. One end of the sampling tube 1 of the gas sampling system is connected to the three-way connector 62. The gas detection system 5 is in fluid communication with the sampling tube 1 and is used to detect at least the concentration of nitric oxide in the gas transmitted through the gas sampling system. A safety assembly 3 is installed between the gas detection system 5 and the sampling tube 1. Furthermore, a humidifier 7 is installed on the inhalation branch 61 upstream of the three-way connector 62.

[0069] This medical gas transmission system effectively reduces the moisture content of the gas when sampling and monitoring nitric oxide-containing gas in the inhalation branch 61. This reduces the burden of frequent water emptying of the downstream water collection cup without affecting the concentration of the analyte in the sample gas, thus helping to improve the detection accuracy of the downstream gas detection system 5. Simultaneously, because a large amount of water vapor is removed as it passes through the pipeline, it rarely accumulates in downstream enclosed equipment for extended periods, effectively reducing the risk of bacterial growth and protecting the health of patients and medical staff.

[0070] To further illustrate the present invention, the following application examples are given. It should be understood that these examples are provided for illustrative purposes and should not be construed as limiting the scope of this disclosure.

[0071] Example Comparison Example 1 The PVC material was extruded into a pipe with an inner diameter of 1.6 mm and an outer diameter of 3.6 mm, and a 2 m length was used to make a sampling tube.

[0072] Comparison Example 2 The silicone material was extruded into a tube with an inner diameter of 1.6 mm and an outer diameter of 3.6 mm, and a 2 m length was used to make a sampling tube.

[0073] Compare Example 3 Polypropylene material was extruded into a tube with an inner diameter of 1.6 mm and an outer diameter of 3.6 mm, and a 2 m length was used to make a sampling tube.

[0074] Example 1 Perfluorosulfonic acid material was extruded into a tube with an inner diameter of 1.6 mm and an outer diameter of 3.6 mm. A 2 m length was then used to make sampling tube 1.

[0075] Example 2 Polyundecylamide material was extruded into a tube with an inner diameter of 1.6 mm and an outer diameter of 3.6 mm. A 2 m length was taken to make sampling tube 1.

[0076] Example 3 Polydodecyl lactam material was extruded into a tube with an inner diameter of 1.6 mm and an outer diameter of 3.6 mm. A 2 m length was then used to make sampling tube 1.

[0077] Example 4 Polydodecyl lactam and polyethylene glycol were mixed (50:50) and extruded to form a tube with an inner diameter of 1.6 mm and an outer diameter of 3.6 mm. A 2 m length was then used to make sampling tube 1.

[0078] Example 5 Polydodecyl lactam and polybutane glycol were mixed (50:50) and extruded to form a tube with an inner diameter of 1.6 mm and an outer diameter of 3.6 mm. A 2 m length was then used to make sampling tube 1.

[0079] Example 6 Perfluorosulfonic acid material is extruded into a tube with an inner diameter of 1.6 mm and an outer diameter of 3.6 mm. A 0.2 m length is taken as the water vapor permeable section 10 of sampling tube 1. A 2 m length of sampling tube 1 is made by combining it with a PVC pipe section.

[0080] Example 7 Polyundecylamide material was extruded into a tube with an inner diameter of 1.6 mm and an outer diameter of 3.6 mm. A 0.2 m length was taken as the water vapor permeable section 10 of the sampling tube 1. A 2 m length of sampling tube 1 was made by combining it with a PVC pipe section.

[0081] Example 8 Polydodecyl lactam material was extruded into a tube with an inner diameter of 1.6 mm and an outer diameter of 3.6 mm. A 0.2 m length was taken as the water vapor permeable section 10 of the sampling tube 1. A 2 m length of sampling tube 1 was made by combining it with a PVC pipe section.

[0082] Example 9 Polydodecyl lactam and polyethylene glycol are mixed (50:50) and extruded to form a pipe with an inner diameter of 1.6 mm and an outer diameter of 3.6 mm. A 0.2 m length is taken as the water vapor permeable section 10 of sampling tube 1. A 2 m length of sampling tube 1 is made by combining it with a PVC pipe section.

[0083] Example 10 Polydodecyl lactam and polybutane glycol are mixed (50:50) and extruded to form a pipe with an inner diameter of 1.6 mm and an outer diameter of 3.6 mm. A 0.2 m length is taken as the water vapor permeable section 10 of sampling tube 1. A 2 m length of sampling tube 1 is made by combining it with a PVC pipe section.

[0084] Performance testing A. Dehumidification Test - A dehumidification test was conducted using the aforementioned medical gas transmission system. The sampling tubes of the gas sampling system were replaced with those of Examples 1 to 10, respectively. The humidity of the gas in the suction branch 61 was set to 100%, and the temperature to 36°C. The gas detection system sampled at a flow rate of 250 ml / min. After 100 hours of testing, the liquid volume in the containment 32 of the safety assembly 3 was observed. The test results are shown in Tables 2 and 3 below: Table 2

[0085] Table 3

[0086] Test results show that the sampling tubes of the prior art (comparative examples 1-3) contain 19 ml of liquid in the container 32 after 100 hours of testing. The sampling tubes 1 (examples 1-10) provided in this embodiment of the invention have obvious dehumidification effects compared with the sampling tubes of the prior art.

[0087] B. Nitric Oxide Absorption Test - A dehumidification test was conducted using the aforementioned medical gas delivery system. The sampling tubes of the gas sampling system were replaced with those from Examples 1 to 10, and the nitric oxide concentration in the inhalation branch was set to 20 ppm. The nitric oxide concentration detected by the gas detection system was observed to determine if there was any change. The test results are shown in Tables 4 and 5 below: Table 4

[0088] Table 5

[0089] Test results show that the sampling tube provided in this embodiment of the invention does not affect the detection results of NO.

[0090] It should be noted that, where there is no conflict, the features in the embodiments of this application can be combined with each other.

[0091] The above description is merely a preferred embodiment of this application and is not intended to limit this application. Various modifications and variations can be made to this application by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this application should be included within the protection scope of this application.

Claims

1. A gas sampling system, characterized in that, include: Sampling tube (1); One end of the sampling tube (1) is used to connect to the intake branch of the mechanical ventilation circuit, and the other end is used to connect to the gas detection system. Nitric oxide gas is injected into the intake branch. The sampling tube (1) is used to pass the gas containing nitric oxide in the intake branch to the gas detection system; At least a portion of the sampling tube (1) is a water vapor permeable section (10), and the wall of the water vapor permeable section (10) is made of a water vapor permeable material; The gas loses water content after passing through the sampling tube (1).

2. The gas sampling system according to claim 1, characterized in that, The moisture absorption rate of the water vapor permeable material is greater than 1%.

3. The gas sampling system according to claim 2, characterized in that, The water vapor permeable material includes one or more of the following: cellulose derivative materials, chitin derivative materials, polyvinyl alcohol and modified materials, amide group-containing materials, and water-absorbing resin materials.

4. The gas sampling system according to claim 3, characterized in that, The water vapor permeable material includes one or more of the following: carboxymethyl cellulose, CA, CP, chitosan, polyvinyl alcohol, polyethylene glycol, polybutylene glycol, polyacrylic acid, perfluorosulfonic acid, PA6, PA11, PA12, PA46, PA66, PESU, PI, sodium polyacrylate, and EVOH.

5. The gas sampling system according to claim 1, characterized in that, The concentration of nitric oxide in the gas decreases by ≤2ppm after passing through the sampling tube (1).

6. The gas sampling system according to claim 1, characterized in that, The total length of the water vapor permeable section (10) is greater than or equal to 20 centimeters; The total length of the water vapor permeable section (10) is set to be more than 10% of the total length of the sampling tube (1).

7. The gas sampling system according to claim 6, characterized in that, The inner diameter of the sampling tube (1) is set to 1-5 mm.

8. The gas sampling system according to any one of claims 1-7, characterized in that, The entire sampling tube (1) is configured as the water vapor permeable section (10).

9. The gas sampling system according to claim 1, characterized in that, The water vapor permeable section (10) is equipped with connector assemblies (2) at both ends.

10. The gas sampling system according to claim 9, characterized in that, The connector assembly (2) includes a connector body (21) and a limiting sleeve (22). The end of the water vapor permeable section (10) is connected to the connector body (21), and the limiting sleeve (22) is fixedly connected to the connector body (21). The limiting sleeve (22) surrounds the outer periphery of the end of the water vapor permeable section (10).

11. The gas sampling system according to claim 1, characterized in that, The gas sampling system also includes a safety component (3), which is connected between the sampling tube (1) and the gas detection system.

12. The gas sampling system according to claim 11, characterized in that, The safety component (3) includes an air inlet (31), a housing (32), a water-proof membrane (33), and an air outlet (34). The air intake component (31) is provided with an air inlet (311), which is connected to the sampling tube (1); Along the gas flow direction, the air inlet (31), the container (32), the water-proof membrane (33), and the air outlet (34) are connected in sequence.

13. A medical gas delivery system, characterized in that, It includes a nitric oxide generator (4), a gas detection system (5), a three-way connector (62), and a gas sampling system as described in any one of claims 1-12; The gas output end of the nitric oxide generator (4) is used to connect with the intake branch (61) of the mechanical ventilation circuit (6); The three-way connector (62) is installed on the intake branch (61) along the gas flow direction, and the three-way connector (62) is located downstream of the connection between the gas output end and the intake branch (61); One end of the sampling tube (1) in the gas sampling system is connected to the three-way connector (62), and the other end is connected to the gas detection system (5); The gas detection system (5) is used to detect at least the concentration of nitric oxide in the gas transmitted via the gas sampling system.

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