Skin care composition containing tussilago farfara leaf extract

Abstract

The invention belongs to the field of daily chemicals, and particularly relates to a tussilago farfara leaf extract-containing skin care composition, which is prepared from the following raw materials in percentage by weight: 0.01 to 10.0 percent of tussilago farfara leaf extract; 0.1 to 15.0% of a humectant; 0.1 to 2.0 percent of panthenol; 5.0 to 30.0% of grease; 1.0 to 10.0% of an emulsifier; 0.1 to 5.0 percent of a thickening agent; 0.5%-2.0% of a preservative; and the balance of pure water. The tussilago farfara leaf extract and panthenol can achieve a synergistic effect, the long-acting moisturizing, relieving and repairing effects of the composition on skin are improved together, meanwhile, adverse effects on a micro-ecosystem and a protective barrier effect of the skin cannot be generated, and the barrier function of the damaged skin can be repaired from the source.

Description

TECHNICAL FIELD

[0001] The present application belongs to the field of daily chemicals, and particularly relates to a skin care composition containing Ginkgo biloba leaf extract. BACKGROUND

[0002] With the development of society, the pace of life of people is accelerating, but the fast pace of life and high pressure environment are easy to cause endocrine disorder of human body. Excessive secretion of stress hormones such as cortisol can inhibit the normal differentiation of keratinocytes, cause the keratin layer to become thin, and reduce the water-locking ability, so that the skin becomes dry and even peels off. The increase of free radicals produced by human body in the high pressure environment can destroy unsaturated fatty acids in the cell membrane, induce inflammatory reaction, and increase the red area of the face and sensitive stinging. In addition, bad habits such as overtime work and irregular diet and pollutants in the environment can disturb sebum metabolism, further weakening the barrier function of the skin.

[0003] In order to adapt to the fast pace of life, people will also choose to use various skin care products to protect and repair the skin, so as to enhance the barrier function of the skin and also maintain a good mental outlook. However, some traditional skin care products currently have strong irritation and single function, and their efficacy often relieves the surface symptoms through occlusive moisturizing, which cannot repair the damaged skin barrier from the root, and long-term use may destroy the microecological balance of the skin. SUMMARY

[0004] The technical problem to be solved by the present application is to provide a skin care composition containing Ginkgo biloba leaf extract. The Ginkgo biloba leaf extract of the present application can synergistically enhance the effect of panthenol, and together improve the long-acting moisturizing, soothing and repairing effect of the composition on the skin, without adversely affecting the microecosystem and protective barrier function of the skin, and can repair the barrier function of the damaged skin from the root.

[0005] The technical scheme adopted by the present application to solve the above problems is as follows: A skin care composition containing Ginkgo biloba leaf extract, comprising the following preparation raw materials in percentage by weight: Ginkgo biloba leaf extract 0.01-10.0%; humectant 0.1-15.0%; panthenol 0.1-2.0%; oil 5.0-30.0%; emulsifier 1.0-10.0%; thickening agent 0.1-5.0%; preservative 0.5-2.0%; and the balance of pure water.

[0006] Through the above technical scheme, the Ginkgo biloba leaf extract has the functions of soothing sensitive skin, reducing skin red area and promoting skin repair, without negatively affecting the microecosystem and protective barrier of the skin, and can repair the barrier function of the damaged skin from the root. In addition, the overall stability of the composition is high and the compatibility is good.

[0007] Further, the preparation method of the leaf extract of Chrysanthemum paludosum, comprising the following steps: S1. washing, drying, crushing and sieving the leaf of Chrysanthemum paludosum to obtain a leaf powder; S2. adding an ethanol solution with a concentration of 60-80% to the leaf powder, the ratio of the leaf powder to the ethanol solution being 1 g of the leaf powder to 20-30 mL of the ethanol solution, and mixing to obtain a mixed solution; S3. placing the mixed solution in a microwave reactor for microwave reaction, the power of the microwave reactor being 600-1200 W, and the time being 10-30 min, and cooling to room temperature after the reaction to obtain a reaction solution; S4. water-bath concentrating the reaction solution, the temperature being 30-50 ℃, the rotation speed being 20-100 rpm, and the time being 1-3 h, and vacuum drying the concentrated sample, the temperature being 30-50 ℃, the vacuum degree being -0.08 to -0.1 MPa, and the time being 1-3 h, to obtain the leaf extract of Chrysanthemum paludosum.

[0008] Further, in step S1, the drying is air drying at room temperature.

[0009] Further, the humectant comprises at least one of glycerin, propylene glycol, 1,3-propanediol, 1,3-butanediol, hyaluronic acid, ceramide, xanthan gum, and sodium PCA.

[0010] By the above technical solution, the appropriate humectant can absorb moisture from the humid air, not only delaying the evaporation of the composition, but also improving the cracking of the composition, and when applied to the skin, the water content of the skin can be increased and the elasticity of the skin can be improved.

[0011] Further, the oil comprises at least one of vegetable oil, animal oil, mineral oil, and synthetic oil.

[0012] By the above technical solution, the vegetable oil is derived from plant seeds and fruits, and is natural, which can reduce the irritation of chemical synthetic reagents to the skin.

[0013] Further, the vegetable oil comprises at least one of olive oil, almond oil, jojoba oil, camellia seed oil, sunflower seed oil, oat kernel oil, shea nut oil, nut oil, and sea buckthorn fruit oil.

[0014] By the above technical solution, the sea buckthorn fruit oil is brownish red, uniform and transparent, and is a natural oil extracted from the fruits of the natural plant sea buckthorn. The main components of the sea buckthorn fruit oil are omega 6, 3 and 9, and in addition to containing unsaturated fatty acids, it is also rich in carotene, natural vitamins A, E, D, K, F and sterols and more than one hundred kinds of bioactive substances.

[0015] Furthermore, the mineral oil includes at least one of white mineral oil, petrolatum, C12-15 alkyl, and paraffin.

[0016] Furthermore, the synthetic oil comprises at least one of polydimethylsiloxane, caprylic / capric triglyceride, isododecane, isopropyl myristate, isopropyl palmitate, and isooctyl palmitate.

[0017] Further, the emulsifier includes at least one of anionic emulsifiers and nonionic emulsifiers; the anionic emulsifier includes at least one of sodium stearoyl glutamate and potassium cetyl phosphate; the nonionic emulsifier includes at least one of cetearyl alcohol ether-6, cetearyl alcohol ether-25, stearyl alcohol ether-2, stearyl alcohol ether-21, glyceryl stearate, PEG-100 stearate, cetearyl glucoside, methyl glucosesquistearate, PEG-20 methyl glucosesquistearate, cetearyl olive oil ester, and sorbitan olive oil ester.

[0018] Through the above methods, anionic and nonionic emulsifiers can increase the compatibility of other components in the composition and the stability of the composition. Anionic emulsifiers have strong emulsifying ability, while nonionic emulsifiers have wide applicability and are mild and have low irritation.

[0019] Furthermore, the thickener includes at least one of the following: acrylate / C10-30 alkanol acrylate crosslinking polymer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate / vinylpyrrolidone copolymer, xanthan gum, and carbomer polymer.

[0020] Through the above technical solution, the thickener can fully expand in water, increase the viscosity of the system, and optimize the appearance and user experience of the composition of the present invention.

[0021] Furthermore, the preservative includes at least two of p-hydroxyacetophenone, 1,2-hexanediol, 1,2-pentanediol, and ethylhexylglycerin.

[0022] The above technical solutions can broaden the antibacterial spectrum, cover more microorganisms, delay the development of microbial resistance, resist environmental interference, improve the stability of the composition, extend the shelf life of the composition, and reduce the amount of a single preservative, thus reducing the irritation of the preservative.

[0023] Furthermore, the above-mentioned skin care composition containing coltsfoot leaf extract also includes at least one of the following preparation ingredients by weight percentage: 0.01-5.0% auxiliary emulsifier; 0.005-0.2% chelating agent; 0.02-0.1% pH adjuster; and 0.01-3% fragrance.

[0024] Furthermore, the auxiliary emulsifier includes at least one of cetyl alcohol, stearyl alcohol, and cetearyl alcohol.

[0025] Furthermore, the chelating agent includes at least one of disodium EDTA, tetrasodium EDTA, tetrasodium glutamate diacetate, and trisodium ethylenediamine disuccinate.

[0026] Furthermore, the pH adjuster includes at least one of sodium hydroxide, potassium hydroxide, triethanolamine, aminomethylpropanol, and arginine.

[0027] Through the above technical solutions, auxiliary emulsifiers can further improve the stability of the system and improve the appearance of the cream emulsion system.

[0028] The present invention has the following beneficial effects: 1. The composition of this invention, through the rational compounding of raw materials, achieves the effects of soothing sensitive skin, reducing redness, and promoting skin repair. Coltsfoot leaf extract synergistically enhances the effects of panthenol, improving the long-lasting moisturizing, soothing, and repairing effects of the composition without adversely affecting the skin's micro-ecosystem and protective barrier function, thus repairing the damaged skin barrier function from the root.

[0029] 2. This invention uses coltsfoot leaves as the preparation material and employs solvent and microwave-assisted extraction to extract the main active ingredient, total flavonoids, thus preparing a coltsfoot leaf extract. The preparation method of the coltsfoot leaf extract in this invention improves the extraction efficiency of coltsfoot leaves, yielding active ingredients with high purity and strong selectivity. Furthermore, through further analysis of the active components, feasible and economically viable extraction and separation routes can be selected in the laboratory stage, providing data support for large-scale production and optimizing industrial production processes. Detailed Implementation

[0030] To make the technical problems, solutions, and advantages of this invention clearer, a detailed description will be provided below with reference to specific examples. However, the scope of protection of this invention is not limited to the following specific embodiments. The described embodiments are merely some, not all, of the embodiments of this invention, and are not intended to limit the invention. Based on the embodiments of this invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this invention.

[0031] Unless otherwise defined, all technical terms used herein have the same meaning as commonly understood by those skilled in the art. The technical terms used herein are for the purpose of describing particular embodiments only and are not intended to limit the scope of the invention.

[0032] Unless otherwise specified, all raw materials, reagents, instruments and equipment used in this invention can be purchased from the market or prepared by existing methods.

[0033] In the quantitative experiments in the following examples, three replicate experiments were set up, and the data are the average of the three replicate experiments or the average ± standard deviation.

[0034] Examples 1-4 and Comparative Examples 1-3 each provide a skin care composition, the specific components and contents of which are shown in Table 1, in units of weight percentage.

[0035] Table 1

[0036] Specifically, the preparation method of the coltsfoot leaf extract in the above embodiments and comparative examples includes the following steps: S1. Wash the coltsfoot leaves, dry them at room temperature, pulverize them, and pass them through a 40-60 mesh sieve to obtain coltsfoot leaf powder; S2. Add a 60% ethanol solution to the coltsfoot leaf powder, with a ratio of 1g coltsfoot leaf powder to 20mL ethanol solution. Mix well to obtain a mixed solution. S3. Place the mixed solution obtained in step S2 into a microwave reactor for microwave reaction. The microwave power is 600W and the time is 10min. After the reaction is completed, cool to room temperature to obtain the reaction solution. S4. The reaction solution is concentrated in a water bath at a temperature of 30°C, a rotation speed of 20 rpm, and a time of 1 hour to obtain a concentrated sample. The concentrated sample is then vacuum dried at a temperature of 30°C, a vacuum degree of -0.08 MPa, and a time of 1 hour to obtain coltsfoot leaf extract.

[0037] The method for preparing the skincare composition of the above embodiments includes the following steps: A1. Raw material preparation: Weigh out the oil and emulsifier as the oil phase, and the moisturizer, thickener and pure water as the water phase according to the formula. Weigh out the remaining raw materials. A2. Heating to dissolve: Heat the oil phase and water phase to 75-85℃ respectively, and stir to completely melt the oil phase components and fully disperse and dissolve the water phase components, keeping the temperature difference between the two phases ≤2℃; A3. Emulsification and homogenization: Under stirring, slowly pour the oil phase into the aqueous phase and homogenize with a homogenizer at 3000 r / min for 5 minutes to form a preliminary emulsion; A4. Cooling and Adding: Cool the emulsion to below 45°C while stirring. Add preservatives, coltsfoot leaf extract, panthenol, and fragrance. Stir at low speed until homogeneous. Cool to 35°C and add sodium hydroxide. Take a sample and dilute it with pure water at a ratio of 1:9. After measuring the pH value to 5-7, stop stirring to obtain the finished product.

[0038] The preparation method for the comparative example is similar; if there are any substances that should not be added, they can be removed in the corresponding preparation steps.

[0039] The above embodiments and comparative examples were evaluated by user sensory assessment and instrument efficacy evaluation. The specific test results are shown in Tables 2 and 3.

[0040] Test method: 1. Selecting volunteers Seventy volunteers aged 20-60 years were randomly divided into seven groups of ten. Groups 1-4 corresponded to Examples 1-4, and groups 5-7 corresponded to Comparative Examples 1-3.

[0041] The efficacy of the product was tested by measuring skin moisture content, skin a* value, transepidermal water loss, and subject self-reports before and after 7, 14, and 28 days of continuous use of the test product in a subject population following skin damage treatment.

[0042] 2. Inspection Principles Moisturizing: The test area showed a significant difference in skin moisture content before and after product use, indicating that the test sample has a moisturizing effect.

[0043] Repair: Before and after product use, compared with the control area, if the transepidermal water loss of the skin at any viewing point is significantly reduced, the a* value is significantly reduced, or the skin moisture content is significantly increased, it indicates that the test sample has a repair effect; otherwise, it does not have a repair effect.

[0044] Soothing effect: Before and after product use, if the a* value of any viewing point in the sample area is significantly reduced compared to the control area, or if the transepidermal water loss of the skin is significantly reduced or the skin moisture content is significantly increased, it indicates that the test sample has a soothing effect; otherwise, it does not have a soothing effect.

[0045] 3. Testing Process (1) No products (cosmetics or topical medications) should be used on the test area for 3 days prior to the test, and the area should not come into contact with water for 3 hours. Before the test, the test area should be cleaned uniformly by wiping it clean with a dry tissue. The skin on the arm was treated with 1% SLS (sodium lauryl sulfate) the day before the test. After 24 hours, the patch was removed, and the test was performed 30 minutes later. Before the test, the subjects should sit quietly for at least 20 minutes in a laboratory with a temperature of 20-22°C and a relative humidity of 40-60%, without drinking water or beverages, with the test area exposed and remaining relaxed. Baseline values ​​(T0d) of skin moisture content, transepidermal water loss, and a* value were collected from the test area.

[0046] (2) Sample application: Use (2.0±0.1) mg / cm³ in the sample area. 2 The test samples were used in the control area, while no product was used in the control area.

[0047] (3) After using the product, the transdermal water loss, skin moisture content and a* value of the test area were collected 7 days, 14 days and 28 days after using the product (T7d / T14d / T28d).

[0048] For the difference analysis, P value < 0.050 indicates a significant difference between before and after sample use; P ≥ 0.050 indicates no significant difference between before and after sample use.

[0049] Table 2

[0050] The test results from Examples 1-4 show that, with the proportional increase in the amount of *Lysimachia christinae* extract added in Examples 1-4, the highest average skin moisture content (18.55%), the highest significant reduction in transepidermal water loss (18.3%), and the highest significant reduction in a* value (23.97%) were observed in the test subjects after 7 days of continuous use of the test sample compared to before the experiment. After 14 days of continuous use of the test sample compared to before the experiment, the highest average skin moisture content (25.32%), the highest significant reduction in transepidermal water loss (28.28%), and the highest significant reduction in a* value (28.35%) were observed. After 28 days of continuous use of the test sample compared to before the experiment, the highest average skin moisture content (28.22%), the highest significant reduction in transepidermal water loss (36.32%), and the highest significant reduction in a* value (38.63%) were observed, indicating that the test sample has moisturizing, repairing, and soothing effects. When the amount of coltsfoot extract added is 5%, the effect of addition and efficacy is better.

[0051] Comparing the test results of Example 3 and Comparative Examples 1-3, it can be seen that Comparative Example 1 did not add coltsfoot leaf extract and panthenol, Comparative Example 2 only added coltsfoot leaf extract, and Comparative Example 3 only added panthenol. The experimental data shows that adding either coltsfoot leaf extract or panthenol alone resulted in lower moisturizing and soothing effects compared to adding both coltsfoot leaf extract and panthenol simultaneously. This indicates that coltsfoot leaf extract and panthenol have a synergistic effect, jointly enhancing the moisturizing, soothing, and repairing effects of the composition of the present invention. Further comparison of the 28-day data in Example 3 and Comparative Example 2 shows that when coltsfoot leaf extract and panthenol are used synergistically, they have long-lasting moisturizing, soothing, and repairing effects.

[0052] After using the sample from Example 3 for 28 days, the subjects performed self-evaluation on the sample from Example 3, and the specific results are shown in Table 3.

[0053] Table 3

[0054] The test data in Table 3 shows that 100.00% of the subjects were satisfied with the product's moisturizing effect; 100.00% of the subjects were satisfied with the product's long-lasting moisturizing effect; 96.66% of the subjects were satisfied with the product's soothing effect; 96.66% of the subjects were satisfied with the product's long-lasting soothing effect; 96.66% of the subjects were satisfied with the product's repairing effect; and 96.66% of the subjects were satisfied with the product's long-lasting repairing effect.

[0055] The preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the scope of the technical concept of the present invention, various simple modifications can be made to the technical solution of the present invention, and these simple modifications all fall within the protection scope of the present invention.

[0056] It should also be noted that the various specific technical features described in the above embodiments can be combined in any suitable manner without contradiction. To avoid unnecessary repetition, the present invention will not describe the various possible combinations separately.

[0057] Furthermore, various different embodiments of the present invention can be combined in any way, as long as they do not violate the spirit of the present invention, they should also be regarded as the content disclosed by the present invention.

Claims

1. A skin care composition comprising an extract of Ginkgo biloba leaves, characterized in that, The preparation raw materials include, by weight percentage: 0.01-10.0% of Ginkgo Leaf Extract; 0.1-15.0% of moisturizing agent; 0.1-2.0% of panthenol; 5.0-30.0% of oil; 1.0-10.0% of emulsifier; 0.1-5.0% of thickening agent; 0.5-2.0% of preservative; and the balance of pure water.

2. The skin care composition containing the extract of the leaves of Ginkgo biloba according to claim 1, characterized in that, The preparation method of the Ginkgo Leaf Extract comprises the following steps: S1. washing, drying, crushing and sieving the Ginkgo Leaf to obtain Ginkgo Leaf powder; S2. adding 60-80% ethanol solution to the Ginkgo Leaf powder, the ratio of the Ginkgo Leaf powder to the ethanol solution being 1g of the Ginkgo Leaf powder to 20-30mL of the ethanol solution, and mixing uniformly to obtain a mixed solution; S3. placing the mixed solution in a microwave reactor for microwave reaction, the power of the microwave reactor being 600-1200W, the time being 10-30min, and the reaction solution being cooled to room temperature after the reaction is completed; S4. water-bath concentrating the reaction solution, the temperature of the water-bath concentration being 30-50℃, the rotation speed being 20-100rpm, the time being 1-3h, vacuum drying the concentrated sample, the temperature of the vacuum drying being 30-50℃, the vacuum degree being -0.08--0.1MPa, and the time being 1-3h, to obtain the Ginkgo Leaf Extract.

3. The skin care composition containing the extract of the leaves of Ginkgo biloba according to claim 1, characterized in that, The moisturizing agent includes at least one of glycerin, propylene glycol, 1,3-propanediol, 1,3-butanediol, hyaluronic acid, ceramide, xanthan gum, and sodium PCA.

4. The skin care composition containing the extract of the leaves of Ginkgo biloba according to claim 1, characterized in that, The oil includes at least one of vegetable oil, animal oil, mineral oil, and synthetic oil.

5. The skin care composition containing the extract of the leaves of Ginkgo biloba according to claim 4, characterized in that, The vegetable oil includes at least one of olive oil, almond oil, jojoba oil, camellia seed oil, sunflower seed oil, oat kernel oil, shea nut butter, nut oil, and sea buckthorn fruit oil.

6. The skin care composition containing the extract of the leaves of Ginkgo biloba according to claim 4, characterized in that, The mineral oil includes at least one of white mineral oil, vaseline, C12-15 alkane, and paraffin.

7. The skin care composition containing the extract of the leaves of Ginkgo biloba as set forth in claim 4, characterized by The synthetic oil includes at least one of dimethicone, caprylic / capric triglyceride, isododecane, isopropyl myristate, isopropyl palmitate, and isooctyl palmitate.

8. The skin care composition containing the extract of the leaves of Ginkgo biloba as set forth in claim 1, characterized by The emulsifier includes at least one of anionic emulsifier and non-ionic emulsifier; the anionic emulsifier includes at least one of sodium stearoyl glutamate and potassium cetyl phosphate; and the non-ionic emulsifier includes at least one of ceteareth-6, ceteareth-25, steareth-2, steareth-21, glyceryl stearate, PEG-100 stearate, cetearyl glucoside, methyl glucose sesquistearate, PEG-20 methyl glucose sesquistearate, cetearyl olivate, and sorbitan olivate.

9. The skin care composition containing Ginkgo biloba leaf extract according to claim 1, characterized in that, The thickening agent includes at least one of acrylates / C10-30 alkyl acrylate crosspolymer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyltaurate / vinylpyrrolidone copolymer, xanthan gum, and carbomer polymer.

10. The skin care composition containing Ginkgo biloba leaf extract according to claim 1, characterized in that, The skin care composition containing the extract of the leaves of Ginkgo biloba L. also includes at least one of the following ingredients in a percentage by weight: an auxiliary emulsifier 0.01-5.0%; a chelating agent 0.005-0.2%; a pH adjuster 0.02-0.1%; and a perfume 0.01-3%.

Images