Cold traditional Chinese medicine formula for preventing epidemic infection and bacterial infection

Abstract

The invention discloses a cold traditional Chinese medicine formula for preventing epidemic infection and bacterial infection. The formula comprises first-grade defense components: 12-15 parts of radix astragali, 10-12 parts of rhizoma atractylodis macrocephalae and 6-9 parts of radix saposhnikoviae; a secondary defense component: 10-12 parts of folium turpiniae and 8-10 parts of cyrtomium fortunei; a third-level defense component: 12-15 parts of honeysuckle, 10-15 parts of folium isatidis, 10-15 parts of wild chrysanthemum flower, 10-12 parts of houttuynia cordata and 10-15 parts of lalang grass rhizome; and a blending component: 5-6 parts of licorice. According to the method, multi-layer defense is constructed, the whole process from non-illness to illness is covered, the first-level defense enhances the external defense exterior consolidation capacity, the immunity of the organism is improved, and diseases are prevented from occurring in the past; secondary defense directly inhibits virus replication and release, and disease development is cut off; and the third-stage defense has the effects of clearing away heat and toxic materials, controlling inflammation and preventing secondary bacterial infection. And three-stage linkage covers all stages from the non-diseased stage to the diseased stage.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a cold traditional Chinese medicine formula for preventing epidemic infection and bacterial infection. BACKGROUND

[0002] Influenza is an acute respiratory infectious disease caused by influenza virus, which has the characteristics of fast transmission, high incidence and easy complications. Seasonal influenza and irregular influenza pandemics pose a serious threat to global public health every year. Influenza virus infection is often followed by bacterial infection, such as pneumonia and otitis media, which further aggravates the disease and increases the mortality rate.

[0003] In the prior art, the cold prevention and treatment formula of traditional Chinese medicine mainly focuses on a single mechanism, such as simply enhancing immunity or clearing heat and detoxifying, and lacks a comprehensive defense system with multiple levels and multiple targets. For example, some formulas mainly rely on Astragalus and Atractylodes to enhance the body's resistance, but have limited effect on viral and bacterial infection; other formulas focus on Honeysuckle and Forsythia to clear heat and detoxify, which can relieve symptoms but have poor preventive effect and may damage the spleen and stomach due to cold and cool nature.

[0004] Therefore, there is an urgent need in the art for a cold traditional Chinese medicine formula that can effectively integrate prevention, intervention and treatment functions, has a multi-level defense mechanism, and takes into account safety and compliance. SUMMARY

[0005] The present application provides a cold traditional Chinese medicine formula for preventing epidemic infection and bacterial infection, aiming to solve the problems existing in the prior art.

[0006] In a first aspect, a cold traditional Chinese medicine formula for preventing epidemic infection and bacterial infection is provided, which includes the following components: first defense component: Astragalus 12-15 parts, Atractylodes 10-12 parts, and Ledebouriella 6-9 parts; Second defense component: Mountain Camphor Leaf 10-12 parts and Rhizoma Anemarrhenae 8-10 parts; Third defense component: Honeysuckle 12-15 parts, Largeleaf Hedyys 10-15 parts, Wild Chrysanthemum 10-15 parts, Fishy Smell Grass 10-12 parts, and White Lotus Root 10-15 parts; Harmonizing component: Licorice 5-6 parts.

[0007] Optionally, the formula can also add Mint 3-5 parts.

[0008] Optionally, the formula can also add Patchouli Oil 1-2 parts.

[0009] The second aspect relates to a preparation method of the cold medicine for preventing epidemic infection and bacterial infection, which is applied to the cold medicine for preventing epidemic infection and bacterial infection, and comprises the following steps: S1: taking each medicinal piece according to the above proportion; S2: using water extraction method, decocting 2-3 times, and combining the filtrates; S3: concentrating the filtrate into thick paste, and drying the thick paste into dry extract under reduced pressure; S4: after the dry extract is crushed, adding appropriate amount of auxiliary materials, granulating, drying, and distributing.

[0010] Optionally, the auxiliary materials in S4 comprise dextrin and microcrystalline cellulose.

[0011] Optionally, the preparation method can also prepare the formula into capsules, tablets, and oral liquids.

[0012] The third aspect relates to an application of the cold medicine for preventing epidemic infection and bacterial infection, which is used for preventing and early treating viral influenza and secondary bacterial infection.

[0013] Optionally, when the cold medicine is used for prevention, it is taken once a day; and when the cold medicine is used for early intervention treatment, it is taken 2-3 times a day.

[0014] Compared with the prior art, the present application has at least the following beneficial effects: The present application covers the whole process from no disease to disease by constructing multiple levels of defense. The first level of defense (Huangqi, Baizhu, Fangfeng) enhances the ability of preventing external evil and strengthening the body surface, and improves the immunity of the body to prevent disease. The second level of defense (Shanxiangyuan leaves and Guanzhong) directly inhibits virus replication and release, and cuts off the development of the disease. The third level of defense (Jinyinhua, Daqingye, Yuxingcao, etc.) clears heat and detoxifies, controls inflammation, and prevents secondary bacterial infection. The three levels of defense cover all stages from no disease to disease.

[0015] The present application not only targets viruses (such as influenza A virus and respiratory syncytial virus), but also inhibits bacteria (such as Haemophilus influenzae, gram-positive and gram-negative bacteria) through Guanzhong and Yuxingcao, effectively preventing bacterial infection secondary to viral influenza, and constructing a double defense line of “anti-virus-anti-bacteria”. DETAILED DESCRIPTION

[0016] In order to make the purpose, technical scheme and advantages of the present application more clear, the present application is further described in detail below with examples.

[0017] This application provides a traditional Chinese medicine formula for preventing influenza and bacterial infections, the formula comprising: 12-15 parts Astragalus membranaceus, 10-12 parts Atractylodes macrocephala, 6-9 parts Saposhnikovia divaricata, 10-12 parts Clematis armandii, 8-10 parts Dryopteris crassirhizoma, 12-15 parts Lonicera japonica, 10-15 parts Isatis indigotica, 10-15 parts Chrysanthemum indicum, 10-12 parts Houttuynia cordata, 10-15 parts Imperata cylindrica, and 5-6 parts Glycyrrhiza uralensis; Specifically, the formula has a three-tiered defense system. The first-tier defense is to strengthen the body's defenses, which includes: Astragalus membranaceus, one of the principal herbs, which invigorates Qi and strengthens the body's defenses, enhances the level of immunoglobulin A in the respiratory mucosa and improves overall immunity, forming the foundation of the defense. Astragalus polysaccharides can significantly enhance the activity of macrophages and natural killer cells (NK cells), promote the proliferation and differentiation of T lymphocytes and B lymphocytes, comprehensively mobilize non-specific and specific immune functions, and induce the body to produce endogenous interferon to interfere with viral replication. Atractylodes macrocephala, as an assistant herb, strengthens the spleen and replenishes qi. Together with Astragalus membranaceus, it enhances the function of "defensive qi" and prevents "where evil gathers, qi must be deficient." Fangfeng, as an adjuvant herb, dispels wind and releases the exterior, assists Huangqi in dispelling pathogens, and prevents them from closing the door and keeping the enemy inside. Primary defense targets the pre-disease stage, enhancing mucosal and bodily immunity to prevent pathogen invasion; Secondary defense is to intercept and reverse the disease, which includes: Sedum morganianum leaf, which is a secondary medicine. Its flavonoid components have been proven to be neuraminidase inhibitors (similar in effect to Tamiflu), which can directly block the release of the virus and interrupt the disease in the early stage. Dryopteris crassirhizoma, used as an adjuvant herb, has a broad antiviral spectrum and inhibits Haemophilus influenzae type b (Hib) and other pathogens, thus constructing a dual defense against viruses and bacteria. Secondary defense targets the initial stages of the disease, directly inhibiting viral replication and release, and preventing the disease from progressing; Level 3 defense involves clearing heat and detoxifying, including honeysuckle, one of the principal herbs, which clears heat and detoxifies and is the first choice for treating febrile diseases. It also has antiviral (especially H1N1) and antibacterial properties. The main active ingredient in honeysuckle is chlorogenic acid, which has a direct inhibitory effect on H1N1 influenza virus, respiratory syncytial virus, etc.; at the same time, it has a broad-spectrum antibacterial effect. Isatis leaf, used as an assistant herb, clears heat and cools the blood, detoxifies and soothes the throat, and has a clear antiviral effect. When combined with honeysuckle, it powerfully combats invading pathogens. Wild chrysanthemum, used as an auxiliary medicine, clears heat and detoxifies, reduces inflammation and relieves pain. It is especially good at treating upper respiratory tract infections and relieving symptoms such as headache and sore throat. Houttuynia cordata, used as an adjuvant, clears heat and detoxifies, drains pus and reduces swelling, especially effective in clearing lung heat. It has antiviral and antibacterial properties and can prevent secondary lung infections. Its core component, houttuynin, has an inhibitory effect on a variety of Gram-positive and Gram-negative bacteria (including Haemophilus influenzae). It also has antiviral, anti-inflammatory, and immune-enhancing effects. When combined with honeysuckle and Dryopteris crassirhizoma, it strengthens the dual defense of "antiviral-antibacterial" in this formula. Rhizoma Imperatae, as a medicinal herb, clears heat and promotes diuresis, generates fluid and relieves cough, makes the pathogenic heat out of the urine, and provides an outlet for the pathogenic factors, at the same time, relieves fever and thirst; The three-level defense is aimed at early stage of the disease, rapid control of inflammation, relief of symptoms, and prevention of secondary bacterial infection; The last licorice is a medicinal herb, used to harmonize the various drugs, clear heat and detoxify, relieve the cold nature of the various drugs, and protect the spleen and stomach; The formula can also add 3-5 parts of mint, which has the effect of dispersing wind-heat, clearing the head and eyes, benefiting the throat, and can significantly improve the taste of oral preparations and improve the medication compliance of patients (especially children). The menthol contained in it can bring a cooling sensation and relieve throat discomfort; The formula can also add 1-2 parts of patchouli oil, which has the effect of resisting influenza A and B viruses, and as a volatile oil, 1-2 parts can fully exert its efficacy, while further enhancing the "aromatic and dispelling evil" power of the whole formula.

[0018] A preparation method of a cold traditional Chinese medicine for preventing epidemic infection and bacterial infection, the method comprising the following steps: S1: Take each piece of the above proportion; S2: Use water extraction method, decoct 2-3 times, and combine the filtrate; S3: Concentrate the filtrate into a thick paste, and dry it under reduced pressure into a dry extract; S4: After the dry extract is crushed, add appropriate amount of auxiliary materials such as dextrin and microcrystalline cellulose, granulate, dry, and pack; It can be made into granules, capsules, tablets or oral liquid; A cold traditional Chinese medicine for preventing epidemic infection and bacterial infection, the cold traditional Chinese medicine is used for preventing and early treating viral influenza and secondary bacterial infection; When the cold traditional Chinese medicine is used for prevention, it is taken once a day; when it is used for early intervention treatment, it is taken 2-3 times a day.

[0019] The technical features of the above embodiments can be combined in any way, and to make the description concise, not all possible combinations of the technical features in the above embodiments are described, however, as long as the combination of the technical features does not exist contradictory, it should be considered as the scope of the present disclosure.

Claims

1. A cold traditional Chinese medicine formula for preventing epidemic infection and bacterial infection, characterized in that, The formula includes, first defense component: Huangqi 12-15 parts, Baizhu 10-12 parts, Fangfeng 6-9 parts; Second defense component: Shanzhuyean leaves 10-12 parts, Guanzhong 8-10 parts; Third defense component: Jinyinhua 12-15 parts, Daqingye 10-15 parts, Yekuixue 10-12 parts, Baomao 10-15 parts; Harmonizing component: Gancao 5-6 parts.

2. The cold herbal formula for preventing epidemic infection and bacterial infection according to claim 1, characterized in that, The formula can also add peppermint 3-5 parts.

3. The cold herbal formula of claim 1, wherein the cold herbal formula is used for preventing epidemic infection and bacterial infection. The formula can also add Guanghuoshao oil 1-2 parts.

4. A preparation method of a cold traditional Chinese medicine for preventing epidemic infection and bacterial infection, applied to the cold traditional Chinese medicine formula for preventing epidemic infection and bacterial infection according to claims 1-3, characterized in that, The method includes the following steps: S1: Take each decoction piece in the above proportion; S2: Use water extraction method, decoct 2-3 times, combine the filtrate; S3: Concentrate the filtrate into thick paste, dry under reduced pressure into dry extract; S4: After crushing the dry extract, add appropriate amount of auxiliary materials, granulate, dry, and pack.

5. The preparation method of the cold traditional Chinese medicine for preventing epidemic infection and bacterial infection according to claim 4, characterized in that, The auxiliary materials in S4 include dextrin and microcrystalline cellulose.

6. The preparation method of the cold traditional Chinese medicine for preventing epidemic infection and bacterial infection according to claim 5, characterized in that, The preparation method can also prepare the formula into capsules, tablets, and oral liquids.

7. The application of the cold medicine of the Chinese medicine for preventing epidemic infection and bacterial infection, characterized in that, The cold medicine is used for preventing and early treating viral influenza and secondary bacterial infection.

8. The application of the cold medicine of preventing epidemic infection and bacterial infection according to claim 7, characterized in that, When used for prevention, the cold medicine is taken once a day; when used for early intervention treatment, the cold medicine is taken 2-3 times a day.