Infant nutritional supplement and preparation method thereof

Abstract

The invention discloses an infant nutritional supplement and a preparation method thereof, and belongs to the technical field of nutritional preparations. The Korean ginseng, the codonopsis pilosula and the coix seed extract are mixed according to a specific mass ratio, and the optimal synergistic balance of the mild regulation effect on the intestinal smooth muscle of the infants, the enhancement effect on the intestinal immune barrier and the promotion effect on digestive enzymes can be achieved, so that the absorption of the infants on nutrient substances is promoted. Small molecule peptides (whey protein hydrolysis peptides and casein phosphopeptides) which are easier to digest and absorb are selected, so that the digestion burden of infants is reduced, and the small molecule peptides are highly consistent with the targets of conditioning the intestinal function and improving the absorption efficiency of a'micro-capsule system '.

Description

Technical Field

[0001] This invention belongs to the field of nutritional preparation technology, specifically relating to an infant nutritional supplement and its preparation method. Background Technology

[0002] Infancy is the period of fastest growth and development, but the digestive system is still immature, with low gastric acid secretion, low digestive enzyme activity, weak intestinal barrier function, and unstable flora. This leads to a common problem of low absorption rates of macronutrients such as protein and fat, as well as key micronutrients. Existing technology one (CN113397164A) provides a complete nutritional formula, but it is not specifically designed for the low absorption efficiency of infants and young children; it mainly focuses on providing comprehensive and balanced nutrients. Existing technology two (CN109965271A) focuses on adding known brain-boosting or digestive-promoting components, such as DHA, ARA, and dietary fiber like inulin. However, it usually involves simply stacking various functional ingredients without fully considering the interactions, stability, and synergistic effects of different components in the complex intestinal environment of infants and young children. For example, some brain-boosting or immune-boosting components may have unpleasant odors or poor stability; adding them directly would affect the product's taste and long-term effectiveness.

[0003] Therefore, there is an urgent need to develop an innovative infant nutritional supplement to systematically address the problems of poor nutrient absorption and weak intestinal function in infants and young children. Summary of the Invention

[0004] In view of the above-mentioned prior art, the present invention provides an infant nutritional supplement and its preparation method to solve the problems of poor nutrient absorption and weak intestinal function in infants.

[0005] To achieve the above objectives, the technical solution adopted by the present invention is to provide an infant nutritional supplement comprising the following components in parts by weight: 10-40 parts of hydrolyzed protein complex, 40-65 parts of carbohydrate complex, Functional compound plant microcapsules, 5-25 parts. 1-5 parts of DHA algal oil microcapsule powder Arachidonic acid microcapsule powder 0.5-3 parts, A prebiotic blend of inulin and galactooligosaccharides, 4-12 parts. Vitamin complex 0.5-5 parts, The functional composite plant microcapsules consist of a core material encapsulated by a wall material. The core material is a mixture of Korean ginseng extract, codonopsis extract, and coix seed extract in a mass ratio of 1.5~3.5:0.8~2.2:0.8~2.2. The wall material includes sodium alginate and maltodextrin, with sodium alginate accounting for 10%~35% of the total dry basis mass of the wall material.

[0006] Based on the above technical solution, the present invention can be further improved as follows.

[0007] Furthermore, the hydrolyzed protein complex is a mixture of whey protein hydrolysate, casein phosphopeptide, and potassium caseinate, with a mass ratio of 5~10:2~5:1.

[0008] Furthermore, the carbohydrate complex is a mixture of dextrin, anhydrous glucose, and fructooligosaccharides.

[0009] Furthermore, the mass ratio of dextrin, anhydrous glucose, and fructooligosaccharides in the carbohydrate complex is 10:1~3:2~5.

[0010] Furthermore, the wall material is composed of sodium alginate and maltodextrin, with a mass ratio of 1:2 to 4.

[0011] Furthermore, the mass ratio of Korean ginseng extract, codonopsis extract, and coix seed extract in the core material is 2~3:1:1.

[0012] Furthermore, the mass ratio of inulin to galactooligosaccharides in the compound prebiotic of inulin and galactooligosaccharides is 1:1.

[0013] Furthermore, the vitamin complex is composed of vitamin B, vitamin C and vitamin E mixed in a mass ratio of 3~5:2~4:1~3.

[0014] This invention also discloses a method for preparing the above-mentioned infant nutritional supplement, characterized by comprising the following steps: S1. Preparation of functional compound plant microcapsules: S11. Take Korean ginseng, codonopsis and coix seed, and prepare extracts by water extraction and alcohol precipitation, and mix the prepared extracts in proportion; S12. Dissolve sodium alginate and maltodextrin in water in the specified proportions to prepare a wall material solution; S13. The mixed extract obtained in step S11 is uniformly dispersed in the wall material solution obtained in step S12, and after homogenization and emulsification, it is spray-dried to obtain the functional composite plant microcapsules. S2. Weigh out the hydrolyzed protein complex, carbohydrate complex, functional compound plant microcapsules, DHA algal oil microcapsule powder, arachidonic acid microcapsule powder, compound prebiotics and vitamin complex according to the formula ratio. S3. All solid powder components weighed in step S2 are mixed in three dimensions under inert gas protection. After uniform mixing, the product is obtained.

[0015] Furthermore, in step S13, the inlet air temperature of the spray drying is 160~180℃, and the outlet air temperature is 70~85℃.

[0016] The beneficial effects of this invention are: 1. This invention mixes extracts of Korean ginseng, codonopsis, and coix seed in a specific mass ratio, which can achieve an optimal synergistic balance in the mild regulation of intestinal smooth muscle, the enhancement of intestinal immune barrier, and the promotion of digestive enzymes in infants and young children, thereby promoting the absorption of nutrients by infants and young children.

[0017] 2. This invention creatively selects sodium alginate and maltodextrin as composite wall materials. Sodium alginate is a pH-sensitive natural polysaccharide that remains stable in the acidic environment of an infant's stomach, preventing the active ingredients from being destroyed or inactivated by gastric acid. In the weakly alkaline environment of the intestines, it swells and releases in a controlled manner, ensuring that the active ingredients exert their maximum effect at the target sites in the intestines (ileum and colon). Maltodextrin provides the necessary film-forming properties and physical support. This combination of wall materials ensures both the encapsulation efficiency of the microcapsules and endows the product with the precise delivery capability tailored to the physiological characteristics of the infant's digestive tract.

[0018] 3. This invention selects small molecule peptides (whey protein hydrolyzed peptides and casein phosphopeptides) that are easier to digest and absorb, reducing the digestive burden on infants and young children, which is highly consistent with the goal of the "microcapsule system" to regulate intestinal function and improve absorption efficiency. Detailed Implementation

[0019] The specific embodiments of the present invention will be described in detail below with reference to examples.

[0020] Example 1 An infant nutritional supplement, comprising the following components in parts by weight: 20 parts of hydrolyzed protein complex, 45 parts of carbohydrate complex, 15 parts of functional compound plant microcapsules, 3 parts of DHA algal oil microcapsule powder, 2 parts of arachidonic acid microcapsule powder, 8 parts of inulin and galactooligosaccharide compound prebiotic, and 3 parts of vitamin complex. The hydrolyzed protein complex is a mixture of whey protein hydrolysate, casein phosphopeptide and potassium caseinate, with a mass ratio of 8:3:1. The carbohydrate complex is a mixture of dextrin, anhydrous glucose and fructooligosaccharides in a mass ratio of 10:2:3. The functional composite plant microcapsules consist of a core material encapsulated by a wall material; the core material is a mixture of Korean ginseng extract, codonopsis extract, and coix seed extract in a mass ratio of 2:1:1; the wall material is composed of sodium alginate and maltodextrin in a mass ratio of 1:3. The mass ratio of inulin to galactooligosaccharides in the compound prebiotic of inulin and galactooligosaccharides is 1:1. The vitamin complex is a mixture of vitamin B, vitamin C and vitamin E in a mass ratio of 4:3:2.

[0021] The infant nutritional supplement in this embodiment is prepared through the following steps: S1. Preparation of functional compound plant microcapsules: S11. Take Korean ginseng, codonopsis and coix seed, and prepare extracts by water extraction and alcohol precipitation, and mix the prepared extracts in proportion; S12. Dissolve sodium alginate and maltodextrin in water in a certain proportion to prepare a wall material solution; S13. The mixed extract obtained in step S11 is uniformly dispersed in the wall material solution obtained in step S12. After homogenization and emulsification, it is spray-dried to obtain the functional composite plant microcapsules. The inlet air temperature of the spray drying is 170℃ and the outlet air temperature is 75℃. S2. Weigh out the hydrolyzed protein complex, carbohydrate complex, functional compound plant microcapsules, DHA algal oil microcapsule powder, arachidonic acid microcapsule powder, compound prebiotics and vitamin complex according to the formula ratio. S3. All solid powder components weighed in step S2 are mixed in three dimensions under inert gas protection. After uniform mixing, the product is obtained.

[0022] Example 2 An infant nutritional supplement, comprising the following components in parts by weight: 10 parts hydrolyzed protein complex, 65 parts carbohydrate complex, 5 parts functional compound plant microcapsules, 5 parts DHA algal oil microcapsule powder, 0.5 parts arachidonic acid microcapsule powder, 12 parts inulin and galactooligosaccharide compound prebiotic, and 0.5 parts vitamin complex. The hydrolyzed protein complex is a mixture of whey protein hydrolysate, casein phosphopeptide and potassium caseinate, with a mass ratio of 5:2:1. The carbohydrate complex is a mixture of dextrin, anhydrous glucose and fructooligosaccharides in a mass ratio of 10:1:2. The functional composite plant microcapsules consist of a core material encapsulated by a wall material; the core material is a mixture of Korean ginseng extract, codonopsis extract, and coix seed extract in a mass ratio of 1.5:2.2:0.8; the wall material is composed of sodium alginate and maltodextrin in a mass ratio of 1:2. The mass ratio of inulin to galactooligosaccharides in the compound prebiotic of inulin and galactooligosaccharides is 1:1. The vitamin complex is a mixture of vitamin B, vitamin C and vitamin E in a mass ratio of 3:4:1.

[0023] The infant nutritional supplement in this embodiment is prepared through the following steps: S1. Preparation of functional compound plant microcapsules: S11. Take Korean ginseng, codonopsis and coix seed, and prepare extracts by water extraction and alcohol precipitation, and mix the prepared extracts in proportion; S12. Dissolve sodium alginate and maltodextrin in water in a certain proportion to prepare a wall material solution; S13. The mixed extract obtained in step S11 is uniformly dispersed in the wall material solution obtained in step S12. After homogenization and emulsification, it is spray-dried to obtain functional composite plant microcapsules. The inlet air temperature of the spray drying is 160℃ and the outlet air temperature is 70℃. S2. Weigh out the hydrolyzed protein complex, carbohydrate complex, functional compound plant microcapsules, DHA algal oil microcapsule powder, arachidonic acid microcapsule powder, compound prebiotics and vitamin complex according to the formula ratio. S3. All solid powder components weighed in step S2 are mixed in three dimensions under inert gas protection. After uniform mixing, the product is obtained.

[0024] Example 3 An infant nutritional supplement, comprising the following components in parts by weight: 40 parts of hydrolyzed protein complex, 40 parts of carbohydrate complex, 25 parts of functional compound plant microcapsules, 1 part of DHA algal oil microcapsule powder, 3 parts of arachidonic acid microcapsule powder, 4 parts of inulin and galactooligosaccharide compound prebiotic, and 5 parts of vitamin complex. The hydrolyzed protein complex is a mixture of whey protein hydrolysate, casein phosphopeptide and potassium caseinate, with a mass ratio of 10:5:1. The carbohydrate complex is a mixture of dextrin, anhydrous glucose and fructooligosaccharides in a mass ratio of 10:3:5. The functional composite plant microcapsules consist of a core material encapsulated by a wall material; the core material is a mixture of Korean ginseng extract, codonopsis extract, and coix seed extract in a mass ratio of 3.5:0.8:2.2; the wall material is composed of sodium alginate and maltodextrin in a mass ratio of 1:4. The mass ratio of inulin to galactooligosaccharides in the compound prebiotic of inulin and galactooligosaccharides is 1:1. The vitamin complex is a mixture of vitamin B, vitamin C and vitamin E in a mass ratio of 5:2:3.

[0025] The infant nutritional supplement in this embodiment is prepared through the following steps: S1. Preparation of functional compound plant microcapsules: S11. Take Korean ginseng, codonopsis and coix seed, and prepare extracts by water extraction and alcohol precipitation, and mix the prepared extracts in proportion; S12. Dissolve sodium alginate and maltodextrin in water in a certain proportion to prepare a wall material solution; S13. The mixed extract obtained in step S11 is uniformly dispersed in the wall material solution obtained in step S12. After homogenization and emulsification, it is spray-dried to obtain functional composite plant microcapsules. The inlet air temperature of the spray drying is 180℃ and the outlet air temperature is 85℃. S2. Weigh out the hydrolyzed protein complex, carbohydrate complex, functional compound plant microcapsules, DHA algal oil microcapsule powder, arachidonic acid microcapsule powder, compound prebiotics and vitamin complex according to the formula ratio. S3. All solid powder components weighed in step S2 are mixed in three dimensions under inert gas protection. After uniform mixing, the product is obtained.

[0026] Experimental Example I. Experimental Animals and Model Establishment: Forty 3-week-old SD mice (weighing 45-60g) were randomly divided into 5 groups of 8 mice each: normal control group, model control group, Example 1 group, control group 1, and control group 2.

[0027] The normal control group was fed a normal basal diet.

[0028] Model control group and other experimental groups: A malabsorption model of young SD rats was established by gavage with lincomycin combined with food restriction.

[0029] Control group 1: Feeded with commercially available regular infant formula milk powder.

[0030] Control group 2: Feeding with a control formula containing "conventional microcapsules" of the same plant extract (Korean ginseng extract) encapsulated in conventional vegetable oil (using only maltodextrin and sodium caseinate as wall materials).

[0031] II. Detection Indicators and Methods: Apparent digestibility: During the experiment (28 days), the crude protein (Kjeldahl method) and crude fat (Soxhlet extraction method) content in feed and feces were determined by the total manure collection method, and the apparent digestibility was calculated.

[0032] Serum biochemical indicators: At the end of the experiment, blood was drawn from the heart, serum was separated, and total protein (TP) and albumin (ALB) were tested to assess overall nutritional status, while diamine oxidase (DAO) and D-lactic acid were tested to assess intestinal permeability.

[0033] Intestinal histopathology and molecular biological indicators: Ileal tissue was taken from each group of rats. Part of the tissue was prepared into sections (HE staining) to observe the morphology and integrity of villi. The expression level of tight junction protein (Occludin, ZO-1) mRNA in another part was detected by qRT-PCR to assess intestinal barrier function.

[0034] Gut microbiota analysis (16S rRNA sequencing): The fecal microbiota of rats in each group was analyzed to assess the ratio of Lactobacillus / Bifidobacterium.

[0035] III. Expected Results (Compared with the model control group and the comparative group): The apparent digestibility of protein and fat in the Example 1 group was significantly higher than that in the model control group and the two comparative groups (P<0.05), and the serum total protein and albumin levels were the highest, while the DAO and D-lactic acid levels were the lowest, indicating that the product of the present invention can effectively improve nutrient absorption and improve intestinal barrier function.

[0036] In Example 1, the intestinal villi structure was the most complete, the expression level of tight junction protein mRNA was the highest, and the abundance of beneficial bacteria in the intestine was significantly improved, which verified the core synergistic effect of the "functional compound plant microcapsules".

[0037] The effect of control group 2 was significantly weaker than that of example group 1, which proves that the technical effect of using a specific wall material (containing sodium alginate) and a specific extract ratio is far superior to that of unconventional microencapsulation technology.

[0038] Although specific embodiments of the present invention have been described in detail with reference to examples, they should not be construed as limiting the scope of protection of this patent. Various modifications and variations that can be made by those skilled in the art without inventive effort within the scope described in the claims are still within the scope of protection of this patent.

Claims

1. An infant nutritional supplement, characterized in that, Components comprising the following parts by weight: 10-40 parts of hydrolyzed protein complex, 40-65 parts of carbohydrate complex, Functional compound plant microcapsules, 5-25 parts. 1-5 parts of DHA algal oil microcapsule powder Arachidonic acid microcapsule powder 0.5-3 parts, A prebiotic blend of inulin and galactooligosaccharides, 4-12 parts. Vitamin complex 0.5-5 parts, The functional composite plant microcapsules consist of a core material encapsulated by a wall material. The core material is a mixture of Korean ginseng extract, codonopsis extract, and coix seed extract in a mass ratio of 1.5~3.5:0.8~2.2:0.8~2.

2. The wall material includes sodium alginate and maltodextrin, wherein sodium alginate accounts for 10%~35% of the total dry basis mass of the wall material.

2. The infant nutritional supplement according to claim 1, characterized in that: The hydrolyzed protein complex is a mixture of whey protein hydrolysate, casein phosphopeptide and potassium caseinate, with a mass ratio of 5~10:2~5:

1.

3. The infant nutritional supplement according to claim 1, characterized in that: The carbohydrate complex is a mixture of dextrin, anhydrous glucose, and fructooligosaccharides.

4. The infant nutritional supplement according to claim 3, characterized in that: The mass ratio of dextrin, anhydrous glucose, and fructooligosaccharides in the carbohydrate complex is 10:1~3:2~5.

5. The infant nutritional supplement according to claim 1, characterized in that: The wall material is composed of sodium alginate and maltodextrin in a mass ratio of 1:2 to 4.

6. The infant nutritional supplement according to claim 1, characterized in that: The mass ratio of Korean ginseng extract, codonopsis extract, and coix seed extract in the core material is 2~3:1:

1.

7. The infant nutritional supplement according to claim 1, characterized in that: The mass ratio of inulin to galactooligosaccharides in the compound prebiotic of inulin and galactooligosaccharides is 1:

1.

8. The infant nutritional supplement according to claim 1, characterized in that: The vitamin complex is composed of vitamin B, vitamin C and vitamin E mixed in a mass ratio of 3~5:2~4:1~3.

9. A method for preparing the infant nutritional supplement according to any one of claims 1 to 8, characterized in that, Includes the following steps: S1. Preparation of functional compound plant microcapsules: S11. Take Korean ginseng, codonopsis and coix seed, and prepare extracts by water extraction and alcohol precipitation, and mix the prepared extracts in proportion; S12. Dissolve sodium alginate and maltodextrin in water in the specified proportions to prepare a wall material solution; S13. The mixed extract obtained in step S11 is uniformly dispersed in the wall material solution obtained in step S12, and after homogenization and emulsification, it is spray-dried to obtain the functional composite plant microcapsules. S2. Weigh out the hydrolyzed protein complex, carbohydrate complex, functional compound plant microcapsules, DHA algal oil microcapsule powder, arachidonic acid microcapsule powder, compound prebiotics and vitamin complex according to the formula ratio. S3. All solid powder components weighed in step S2 are mixed in three dimensions under inert gas protection. After uniform mixing, the product is obtained.

10. The preparation method according to claim 9, characterized in that: In step S13, the inlet air temperature of the spray dryer is 160~180℃ and the outlet air temperature is 70~85℃.