Optimization method for dosage and application time sequence of antibacterial dressing

Abstract

The invention relates to a method for optimizing the dosage and the application time sequence of an antibacterial dressing, which is based on the antibacterial dressing with a segmented enabled structure, the dressing comprises at least two antibacterial action sections, each section is preset with an antibacterial dosage and is isolated by a corresponding isolation part, and a load state indication area and a threshold identifier are arranged; the method comprises the following steps: S1, only starting a first section during laying, and keeping the rest sections isolated; s2, acquiring an indication state of the indication area in use and comparing the indication state with a threshold value; s3, when the threshold value is reached, removing the isolation of the next non-enabled section to enable the non-enabled section to be enabled, and updating the effective antibacterial dosage to the sum of the doses of the enabled sections; s4, repeating the steps S2-S3 until all the action sections are started; and S5, generating a replacement signal when indicating that the threshold value is reached again after all starting. Antibacterial dressings capable of being used in a segmented mode are adopted, load indication and threshold value judgment are combined, the antibacterial dosage is released step by step according to needs, the utilization rate is increased, and the use duration is prolonged; through double-region verification, hysteresis control and in-segment hierarchical regulation and control, false triggering is avoided, and time-space collaborative precise drug release is realized.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, specifically to a method for optimizing the dosage and application sequence of antibacterial dressings. Background Technology

[0002] Current technologies, such as the waterproof, antibacterial, and breathable dressing and its preparation method (publication number CN114392381A), while achieving a certain degree of antibacterial and sustained-release effects through structural elements such as a waterproof layer, an absorbent layer, and a dressing contact layer containing an antibacterial agent chitosan microsphere-calcium alginate fiber composite, still fundamentally rely on a one-time, integral loading, passive release structure. The basic composition of this dressing involves uniformly loading antibacterial agent chitosan microspheres into calcium alginate fibers, coating the absorbent layer, and then combining it with a waterproof and breathable membrane to form a complete dressing. During use, all antibacterial agents are within the same release system; there is no segmented isolation or graded activation structure, nor is there a dynamic triggering mechanism related to wound exudate load. Although it achieves a drug release curve with initial burst release and subsequent sustained release through microsphere encapsulation and alginate fiber carrier, this release process is essentially an inherent diffusion-controlled behavior of the material and cannot be actively adjusted according to changes in actual wound exudate, infection load, or environmental humidity. The drug release rate is largely determined upon application, lacking the ability to adjust the antibacterial dosage in real-time based on the wound's workload. If exudation suddenly increases at a certain stage, the existing release rate may be insufficient to manage the infection risk, while at lower exudation stages, drug resources may be prematurely depleted. Furthermore, the document lacks any indication of wound workload, threshold markers, or trigger mechanisms, leaving healthcare professionals to rely solely on experience to determine dressing replacement needs. This lack of quantitative data can easily lead to premature or delayed dressing changes, impacting treatment effectiveness and resource utilization efficiency.

[0003] While this technology emphasizes achieving a certain degree of sustained-release effect through chitosan microsphere particle size control, drug loading optimization, and composite structure enhancement, its overall drug layer is a single continuous structure, not divided into multiple independently usable antibacterial action segments, nor does it include an isolation section to control phased delivery. All drugs are in a state of being accessible to bodily fluids and participating in diffusion immediately after initial application, making true on-demand refill impossible. Even if there is a difference between burst release and sustained release phases, this difference stems solely from the material's internal diffusion kinetics, rather than from logical control based on load changes. This type of structure also suffers from the problem of difficulty in reversing or compensating for a large release of some drugs; if the risk of infection increases again later, there is no new independent dose reserve within the dressing that can be selectively activated. Furthermore, this approach lacks a mechanism for determining the spatial location of the penetration front, and does not include sequential trigger markers or irreversible state markers to determine whether the liquid has reached a specific area, thus failing to achieve directional matching between dose release and penetration path. While the document emphasizes waterproof and breathable performance and the selection of antibacterial agents, it does not establish a control logic related to the timing of use. The entire technical system is more focused on optimizing material formulation and preparation methods than on managing the dosage of antibacterial agents and controlling the application rhythm. Summary of the Invention

[0004] The purpose of this invention is to provide an optimized method for the dosage and application sequence of antibacterial dressings, thereby addressing some of the drawbacks and shortcomings pointed out in the background art.

[0005] The present invention addresses the aforementioned technical problems by employing the following technical solution: a method for optimizing the dosage and application sequence of antibacterial dressings, comprising: an antibacterial dressing with a segmented, operable structure, wherein the dressing includes at least two antibacterial action segments, each segment having a pre-set antibacterial dose and being isolated by a corresponding isolation section, and is equipped with a load status indicator area and a threshold indicator; the method includes:

[0006] S1. Only the first section is used during installation, and the remaining sections are kept isolated;

[0007] S2. During use, obtain the indication status of the indicator area and compare it with the threshold;

[0008] S3. When the threshold is reached, the isolation of the next unused segment is lifted to enable it, so that the effective antibacterial dosage is updated to the sum of the dosages of the already enabled segments;

[0009] S4. Repeat S2-S3 until all active segments are enabled;

[0010] S5. When all indicators are enabled, a replacement signal is generated when the threshold is reached again.

[0011] Furthermore, the load status indication area includes a main indication sub-area and a verification sub-area; in step S2, the indication status of the two are obtained respectively and a consistency judgment is performed; only when both reach or exceed the threshold mark and the consistency is established, S3 or S5 is executed, otherwise S2 is continued.

[0012] Furthermore, the threshold identifier includes a trigger threshold and a reset threshold, and the reset threshold is lower than the trigger threshold; after the next segment is enabled in step S3, step S2 will only allow the determination to be triggered again if the indicated state falls back to within the reset threshold or after a preset locking time.

[0013] Furthermore, the isolation section of each antibacterial action segment is divided into at least two independently releasable sub-isolation zones; in step S3, when the threshold is reached for the first time, only the first sub-isolation zone is released to enable the first dose portion; when the threshold is reached again in the partially enabled state of this segment, the second sub-isolation zone is released to enable the remaining dose portion.

[0014] Furthermore, the sub-isolation zones are arranged sequentially along the expected advance direction of the penetration front, such that the first sub-isolation zone corresponds to the area close to the load status indicator area and the second sub-isolation zone corresponds to the area far away from the load status indicator area; in step S3, the corresponding sub-isolation zones are released according to the arrangement order.

[0015] Furthermore, after the first sub-isolation zone is released for the first time, a locking determination is entered, and the release of the second sub-isolation zone is prohibited within a preset locking duration; the second sub-isolation zone is released to enable the remaining dose portion only when the indication status of the load status indicator zone still reaches or exceeds the threshold after the locking duration ends.

[0016] Furthermore, the load status indication area is provided with a direction mark consistent with the expected direction of advancement; during the laying in step S1, the direction mark is aligned with the preset main direction of penetration of the target coverage area, and if the laying direction is not adjusted according to the criteria.

[0017] Furthermore, a sequential trigger mark is set at the boundary between the first sub-isolation zone and the second sub-isolation zone; when the indication status is obtained in step S2, it is determined whether the penetration front reaches the sequential trigger mark; the second sub-isolation zone is allowed to be released only when the penetration front reaches the sequential trigger mark, otherwise the first sub-isolation zone is allowed to be released only.

[0018] Furthermore, the sequential triggering marker is a variable state marker, which includes an initial state and a triggering state; the variable state marker changes from the initial state to the triggering state when the penetration front arrives and remains irreversible; in step S2, whether the variable state marker is in the triggering state is used as the basis for determining whether the target has been reached.

[0019] Furthermore, the variable state marker includes a liquid absorption trigger layer and a communicating color development layer disposed at the boundary between the first sub-isolation zone and the second sub-isolation zone; when the permeation front reaches the liquid absorption trigger layer, the color development layer develops color to form the trigger state, and the liquid absorption trigger layer restricts liquid backflow through unidirectional barrier.

[0020] The beneficial effects of this invention are as follows: By designing the antibacterial dressing with a segmented, activatable structure and combining it with a load status indicator area and a threshold determination mechanism, dynamic matching between the antibacterial dosage and the actual usage load is achieved. Initially, only the first antibacterial action segment is activated, while the remaining segments remain isolated, allowing the antibacterial dosage to be released gradually as needed, avoiding waste caused by a one-time full-volume application. By continuously acquiring the indicator status and comparing it with the threshold during use, each additional dose is based on the actual load reaching a critical state, thereby extending the effective usage time of a single dressing and improving the efficiency of antibacterial resource utilization. Furthermore, by setting a main indicator sub-area and a verification sub-area for consistency judgment, and by setting a trigger threshold and a reset threshold to form a hysteresis control range, false triggering problems caused by instantaneous fluctuations or local anomalies can be effectively avoided, improving the stability and reliability of the activation determination.

[0021] Within each individual antibacterial action segment, independently releasable sub-isolation zones are incorporated, enabling a dual-regulation structure for dose release that combines inter-segment progression with intra-segment gradation. This, combined with preset lockout durations and sequential trigger markers, achieves coordinated control across both temporal and spatial dimensions. By arranging the sub-isolation zones along the expected direction of penetration, and incorporating irreversible variable state markers, as well as liquid absorption trigger layers and color development layers, the activation of the second sub-isolation zone must simultaneously meet both load intensity and penetration arrival conditions. This ensures that the antibacterial dose release sequence aligns with the actual liquid propagation path. Attached Figure Description

[0022] Figure 1 This is a logic diagram for determining the segmented activation and replacement of the antibacterial dressing of the present invention.

[0023] Figure 2 This is a schematic diagram of the main verification indicator signal threshold and segmented activation timing in Embodiment 1 of the present invention.

[0024] Figure 3 This is a schematic diagram of the dual-channel consistency judgment and false triggering suppression in Embodiment 1 of the present invention.

[0025] Figure 4 This is a diagram showing the bacterial load differential equation model and the cumulative antibacterial effect of segmented activation in Embodiment 1 of the present invention.

[0026] Figure 5 This is a time-of-arrival diagram of the diffusion-dominated penetration front and the sequential triggering markers in Embodiment 2 of the present invention.

[0027] Figure 6 This is a schematic diagram of the Z2 release window under the joint constraint of locking determination and sequential triggering in Embodiment 2 of the present invention.

[0028] Figure 7 This is a comparison diagram of the key release points and antibacterial effects of the graded release unit and the non-graded control in Embodiment 2 of the present invention. Detailed Implementation

[0029] The specific embodiments of the present invention will now be described in detail with reference to the accompanying drawings.

[0030] Combined with appendix Figure 1 This invention discloses a method for optimizing the dosage and application sequence of antibacterial dressings. The antibacterial dressing uses a segmented, activatable structure, comprising at least two sequentially arranged antibacterial action segments: a first antibacterial action segment, a second antibacterial action segment, and a third antibacterial action segment. Each antibacterial action segment has a pre-set antibacterial dosage, and the segments are initially isolated from each other by corresponding isolation sections to prevent unactivated portions from prematurely engaging in antibacterial action and wasting medication. The dressing also includes a load status indicator area and a corresponding threshold indicator. The load status indicator area reflects the dressing's response to changes in exudate, moisture level, or localized load during use, while the threshold indicator provides a criterion for determining whether to activate the next antibacterial action segment.

[0031] In step S1, when the user applies the antibacterial dressing to the target coverage area, only the first antibacterial action segment is activated, while the second and subsequent antibacterial action segments remain isolated. At this time, the first antibacterial action segment directly participates in the initial antibacterial treatment, forming the initial effective antibacterial dosage. Since the remaining antibacterial action segments are not yet connected to the working area, their pre-set antibacterial dosage will not be released initially. This allows the dressing to work with a lower but sufficient antibacterial dosage in the initial stage of use, thus avoiding the need to administer the entire antibacterial dosage at once when the exudate load is low. In step S2, during the use of the dressing, the operator continuously or intermittently obtains the indication status of the load status indicator area and compares this indication status with a threshold indicator. When the indication status has not yet reached the threshold indicator, it indicates that the currently activated antibacterial action segment can still meet the usage requirements, and the dressing continues to maintain its current activated state. At this time, there is no need to remove any new isolation sections, and the system maintains the current effective antibacterial dosage unchanged. When the indication status reaches the threshold, it means that the working capacity corresponding to the currently activated antibacterial dose has approached the load limit, and the existing antibacterial effect intensity is insufficient to cover the subsequent use needs, and a new antibacterial action segment needs to be added to work.

[0032] In step S3, when the comparison result shows that the indication state of the load status indicator area has reached the threshold, the isolation section of the next inactive antibacterial action segment is released, changing the segment from an isolated state to an active state. Taking the aforementioned three-segment structure as an example, when the first antibacterial action segment is active and the indication state reaches the threshold for the first time, the isolation section corresponding to the second antibacterial action segment is released, allowing the second antibacterial action segment to begin participating in antibacterial action. At this time, the effective antibacterial dosage of the dressing is updated to the sum of the preset dose of the first antibacterial action segment and the preset dose of the second antibacterial action segment. The updated effective antibacterial dosage does not simply represent the total amount of drug, but rather the total dose that has been permitted to participate in actual antibacterial work at the current moment. If, during subsequent use, the load status indicator area reaches the threshold again, the isolation section of the next inactive antibacterial action segment is released, enabling the third antibacterial action segment, and the effective antibacterial dosage is updated again to the sum of the doses of the first, second, and third antibacterial action segments.

[0033] In step S4, steps S2 and S3 are repeated until all antibacterial action segments are activated. At each stage, the current load status is first determined via the load status indicator area, and then the next antibacterial dose is released based on whether a threshold has been reached. This process embodies a phased, progressive antibacterial management logic. The dressing does not release all its antibacterial capacity at the start of application, but gradually expands its working range as the load changes during actual use, making it more suitable for wound environments where exudation levels change over time. After all antibacterial action segments are activated, step S5 continues to monitor the load status indicator area. If the indicator status reaches the threshold again, it indicates that even though all preset antibacterial doses have been used, the overall working capacity of the dressing is close to or has reached its upper limit. Continued use cannot guarantee the expected antibacterial effect and absorption capacity, thus generating a replacement signal. The replacement signal can use color warnings, text displays, labels, or other easily identifiable prompts to remind the user to replace the dressing in a timely manner.

[0034] The load status indication area includes a main indicator area and a verification area, both located within the visible area of ​​the dressing body and corresponding to the activation logic of the antibacterial action section. The main indicator area directly reflects changes in the wound exudate load or wetting expansion state, producing identifiable status changes in response to fluid infiltration, ion concentration changes, or pressure changes.

[0035] In step S2, instead of acquiring the state of a single indicator area, the indicator states of the main indicator sub-area and the verification sub-area are acquired separately. This acquisition can be done by visually observing the degree of color change, the area of ​​the exposed mark, or the liquid reaching the boundary position, or by using a simple reading device. After acquisition, the indicator state of the main indicator sub-area is compared with a threshold identifier, and simultaneously, the indicator state of the verification sub-area is compared with the same or corresponding threshold identifier.

[0036] Step S3 or S5 is executed only when the indication states of both the main indicator sub-area and the verification sub-area reach or exceed the threshold, and the consistency judgment is successful. If there are still unactivated antibacterial action segments at this time, step S3 is executed to release the isolation section of the next unactivated segment, enabling it and updating the effective antibacterial dosage. If all antibacterial action segments are activated, step S5 is executed when the above dual judgment is successful, generating a replacement signal. If, in step S2, it is found that only one of the main indicator sub-area and the verification sub-area reaches the threshold, or if both are close to the threshold but the degree of change is inconsistent, then consistency is considered not successful, step S3 or S5 is not executed, the current activated state is maintained, and step S2 is repeated for continuous monitoring.

[0037] The threshold identifier is no longer a single threshold, but includes a trigger threshold and a reset threshold, with the reset threshold being lower than the trigger threshold. The trigger threshold is used to determine whether the next antimicrobial action segment needs to be activated or whether a replacement signal needs to be generated, while the reset threshold is used to limit the preconditions for triggering the determination again after an activation action has been completed.

[0038] When the indicated state reaches or exceeds the trigger threshold, step S3 is executed according to the aforementioned logic to enable the next unactivated antimicrobial action segment, or step S5 is executed to generate a replacement signal if all antimicrobial action segments are already activated. After step S3 is completed, the system enters the restricted determination phase. At this time, even if the indicated state is still close to the trigger threshold, it is not immediately allowed to trigger the next segment activation operation again. Only when the indicated state in the load status indicator area falls back to within the reset threshold, indicating that the currently activated antimicrobial dose has effectively alleviated the load and the system has returned to a relatively stable range, is step S2 allowed to re-enter the trigger determination phase.

[0039] After the next antibacterial action segment is activated in step S3, the system enters a locking phase. During this preset locking period, step S2 continues to acquire the indication status but does not perform any new trigger determinations. Only after the locking period ends will step S2 allow the indication status to be effectively compared with the trigger threshold again. The locking period can be set based on the antibacterial agent release rate, dressing absorption and diffusion time, or clinical experience. Its purpose is to give the newly activated antibacterial action segment time to fully exert its effect and avoid re-triggering due to short-term fluctuations before a stable effect has been formed.

[0040] The isolation section of each antimicrobial action segment is no longer a single, monolithic area, but is divided into at least two independently releasable sub-isolation zones. For ease of explanation, we will use the example of dividing the isolation section of each antimicrobial action segment into a first sub-isolation zone and a second sub-isolation zone. The first sub-isolation zone corresponds to the first dose portion of the antimicrobial action segment, and the second sub-isolation zone corresponds to the remaining dose portion. Both sub-isolation zones are initially in a closed or blocked state, maintaining isolation between the corresponding antimicrobial dose portion and the working area.

[0041] During the execution of step S3, when the indication status of the load status indicator area reaches or exceeds the trigger threshold for the first time, the entire next antibacterial action segment is not immediately activated. Instead, only the first sub-isolation zone of that segment is deactivated, allowing the first dose portion to connect with the working interface of the dressing, thus forming a partially activated state. At this time, the antibacterial action segment only releases the first dose portion of its preset total dose, and the effective antibacterial dosage is updated to the sum of the doses of all previously activated segments and the first dose portion of this segment.

[0042] After the antibacterial action segment is in a partially activated state, the indication state of the load status indication area is obtained according to step S2 and compared with the trigger threshold. When the indication state reaches or exceeds the trigger threshold again in the partially activated state, it indicates that the first dose portion alone is still insufficient to meet the current load demand. At this time, the second sub-isolation zone is released, enabling the remaining dose portion of the antibacterial action segment, thereby putting the segment into a fully activated state.

[0043] Sub-isolation zones within each antibacterial action zone are arranged sequentially along the expected direction of the penetration front. The expected direction of the penetration front refers to the main expansion path formed in the absorbent or conductive layer after wound exudate or external fluid enters the dressing under normal use conditions. This direction can be predetermined based on the dressing structure design, material conductivity, and clinical usage habits.

[0044] The first sub-isolation zone is located near the load condition indicator zone. This zone is in initial contact with the permeation front, thus enabling earlier detection of load changes. The second sub-isolation zone is located further away from the load condition indicator zone, downstream or distal to the first sub-isolation zone. As the liquid gradually expands along the expected direction of propagation, it affects the side closest to the indicator zone and then gradually advances towards the side furthest from the indicator zone.

[0045] In step S3, when the load status indicator reaches the trigger condition, the corresponding sub-isolation zones are deactivated according to the above arrangement sequence. Upon initial triggering, only the first sub-isolation zone closest to the load status indicator is deactivated, allowing the corresponding first dose portion to participate in operation. If the trigger condition is met again while this segment is in a partially activated state, then the second sub-isolation zone furthest from the load status indicator is deactivated, allowing the remaining dose portion to be used.

[0046] When the load status indicator reaches or exceeds the trigger threshold for the first time, the first sub-isolation zone is released, allowing the antibacterial action segment to enter a partially enabled state. A preset lockout duration is calculated from the moment the first sub-isolation zone is released. Within this preset lockout duration, even if the load status indicator remains close to the trigger threshold, or briefly reaches the trigger threshold again, the second sub-isolation zone is not allowed to be released. Step S2 continues to acquire the indicator status during this period, but does not make an enable determination for the second sub-isolation zone, thus creating a time buffer.

[0047] After the preset lockout period ends, the system will allow triggering of the second sub-isolation zone again. At this time, the load status indicator needs to be retrieved again and compared with the trigger threshold. Only if the indicator status still reaches or exceeds the threshold after the lockout period ends, indicating that the first dose portion has failed to effectively reduce the load status to a safe range, will the system release the second sub-isolation zone, changing the antibacterial action segment from partially activated to fully activated, and then activating the remaining dose portion. If the indicator status has fallen below the trigger threshold by the end of the lockout period, the current partially activated state will be maintained, and the second sub-isolation zone will not be released.

[0048] The load status indication area is equipped with directional markers that correspond to the expected advance direction of the aforementioned penetration front. The directional markers can be arrow-shaped, linearly extending, or other graphic structures with clear directionality. They are preferably located in a visible area of ​​the dressing surface so that they can be directly identified by the operator during installation.

[0049] The intended direction of advancement is the main direction of fluid expansion determined during the dressing design phase based on the material's flow-guiding structure, absorbent layer distribution, and common clinical exudation pathways. To ensure that the graded release of the antibacterial dose corresponds to the penetration pathway, the directional markers must be aligned with the preset main penetration direction of the target coverage area during step S1 when applying the antibacterial dressing. The preset main penetration direction of the target coverage area refers to the main direction of exudate flow or diffusion determined based on wound morphology, the direction of gravity, and the patient's position.

[0050] During application, before covering the target area with the dressing, the operator should first observe the direction indicated by the directional markers and determine the main direction of penetration in the target area. Then, adjust the rotation angle of the dressing to ensure the direction indicated by the directional markers is roughly aligned with the main direction of penetration before applying and securing it. If the directional markers are not aligned with the preset main direction of penetration during initial placement, adjust the dressing's orientation until they are aligned before it is fully secured.

[0051] A sequential trigger marker is placed at the boundary between the first and second sub-isolation zones. The sequential trigger marker is positioned at the junction of the two sub-isolation zones, its location matching the expected advance direction of the aforementioned penetration front, thus serving as a spatial reference point for determining whether the penetration level has reached the second dose release condition. The sequential trigger marker can be a chromatic band, interface line, wettable developing layer, or other structural form capable of producing identifiable changes upon liquid arrival, its purpose being to provide a clear physical arrival criterion.

[0052] While obtaining the load status indication status in step S2, it is also necessary to determine the position of the permeation front. Determining whether the permeation front has reached the sequential trigger mark means observing whether the liquid wetting area has extended to that boundary position, or observing whether the sequential trigger mark has undergone a preset state change. If the permeation front has not yet reached the sequential trigger mark, it indicates that the liquid has not yet expanded to the area where the second sub-isolation zone is located. In this case, even if the load status indication zone reaches the trigger threshold, only the first sub-isolation zone is allowed to be deactivated to activate the first dose portion, but the second sub-isolation zone is not allowed to be deactivated.

[0053] When step S2 determines that the load status indication area has reached the trigger threshold, and simultaneously confirms that the penetration front has reached the sequence trigger mark, the second sub-isolation zone can be released, allowing the antibacterial action section to change from a partially activated state to a fully activated state. If only the threshold condition is met but the penetration arrival condition is not met, the activation condition is considered incomplete, and only the first sub-isolation zone remains in the released state.

[0054] The variable state marker has two states: an initial state and a triggered state. When the dressing is not used or the penetration front has not yet reached the location, the variable state marker is in the initial state. The initial state can be represented by a first color, a first pattern, or an unrevealed state. As the penetration front advances to the boundary between the first and second sub-isolation zones, the liquid comes into contact with the variable state marker, causing a change in its structure or material state, thus transitioning it from the initial state to the triggered state. The triggered state can be represented by a second color, a second pattern, or a revealed state that is clearly different from the initial state, allowing for visual identification by the operator.

[0055] The variable state marker remains irreversible after transitioning from the initial state to the triggered state. Irreversible means that even if subsequent liquid evaporation or a temporary decrease in load conditions occur, the variable state marker will not revert to the initial state but will continue to display the triggered state.

[0056] In step S2, while acquiring the load status indication area status, it is also necessary to determine the current status of the variable status marker. Specifically, this is done by observing whether the variable status marker is in a triggered state. Only when the load status indication area reaches the trigger threshold and the variable status marker is in a triggered state is the spatial condition for releasing the second sub-isolation zone considered met. If the variable status marker is still in the initial state, it indicates that the permeation front has not yet reached the boundary position. Even if the indication status reaches the threshold, releasing the second sub-isolation zone is not allowed; only the first sub-isolation zone remains active.

[0057] The variable state marker includes a liquid absorption trigger layer located at the boundary between the first and second sub-isolation zones, and a color-developing layer connected to it. The liquid absorption trigger layer is situated on the expected propagation path of the permeation front and is used to preferentially absorb exudate when the liquid reaches the boundary. A fluid connection is formed between the color-developing layer and the liquid absorption trigger layer, allowing the liquid absorbed by the liquid absorption trigger layer to be transferred to the color-developing layer region. The color-developing layer contains a color-developing material sensitive to the liquid or its components, producing a noticeable color change upon contact with the liquid.

[0058] During dressing application, before the penetration front reaches the boundary between the first and second sub-isolation zones, the absorbent trigger layer remains unwetted, and the chromogenic layer maintains its initial color or is unchromogenic. At this time, the variable state marker is in its initial state. When the penetration front advances to the boundary and contacts the absorbent trigger layer, the liquid is absorbed by the absorbent trigger layer and transferred to the chromogenic layer via the connecting path. The chromogenic layer undergoes a color reaction under the influence of the liquid, forming a color area distinctly different from the initial state, thus constituting the triggered state. This color change provides a clear visual contrast, facilitating identification and judgment by the operator in step S2.

[0059] To ensure the stability of the triggered state, the liquid absorption trigger layer is equipped with a unidirectional barrier structure. The unidirectional barrier structure can be achieved through material density gradient, microporous structure directionality, or hydrophilic-hydrophobic stacked structure, allowing the liquid to migrate from the first sub-isolation region towards the color development layer, while making it difficult for reverse backflow to occur.

[0060] Example 1:

[0061] The antibacterial dressing is a rectangular composite dressing with dimensions of 100mm × 100mm and a total effective contact area of ​​100cm². It comprises three antibacterial action sections, arranged sequentially along the length of the dressing. Each section has a pre-set antibacterial dose and is isolated by a corresponding isolation section. The isolation section is a combination of a tear-off isolation film and a heat-fused isolation line, isolating the antibacterial layer of unused sections from exudate. The pre-set antibacterial dose is 8mg for the first section, 6mg for the second, and 6mg for the third. The antibacterial agent is silver ion-loaded porous cellulose microparticles, uniformly dispersed within a hydrogel matrix and adhered to the absorbent layer within each section.

[0062] The dressing is equipped with a load status indicator area, located in the observation window near the edge of the first section of the dressing. This area includes a main indicator sub-area and a verification sub-area. The main indicator sub-area uses an impedance-type sensing layer with an initial impedance of 1200Ω, decreasing as the absorbent load increases. Sampling frequency is once every 30 minutes. The verification sub-area uses a colorimetric verification layer, representing the indicator status with grayscale values. The initial grayscale value is 30, increasing as the absorbent load increases. Sampling frequency is also once every 30 minutes. To ensure consistent judgment, a normalized indicator value for the main indicator is defined. Where Z is the real-time impedance, and the verification normalization indicator is defined. , where G is the real-time grayscale value and is limited to the range of 0 to 1.

[0063] Set a threshold indicator next to the indicator area, including the trigger threshold. With reset threshold ,and The physical meaning of the threshold is a comprehensive indication of the state when the liquid absorption load reaches a critical level. The critical liquid absorption capacity is defined as follows: mL, corresponding to an I value in the indicator area reaching or exceeding 0.80. The reset threshold corresponds to the aspiration load falling back to [value missing]. When the mL or equivalent indicator value falls back to within 0.65, the determination can be triggered again. Figure 2 It displays the curves of the main indicator and verification indicator changing over time, the trigger threshold and reset threshold, and the key activation and replacement points.

[0064] The consistency judgment rule is set to only when and and Only when the next inactive segment is enabled or a replacement signal is generated, is execution permitted. If any condition is not met, the read and compare operations will continue, and the isolation will not be lifted. Figure 3 The diagram shows the scatter distribution of the main indicator and the verification indicator in a two-dimensional plane, as well as the consistency band that meets the triggering conditions, thus intuitively expressing the difference between a false trigger being rejected and a valid trigger being established.

[0065] The application scenario is postoperative incision care in orthopedic wards. On the day of surgery (0h), nurses apply the dressing to the incision surface, using only the first section at a time; the second and third sections are kept separate. Nurses record the start time and read the indicator area every 30 minutes. The reading method involves measuring the main indicating impedance with a small bedside reader and using a mobile phone camera to read the grayscale of the verification sub-area, which is then converted to obtain... and The discrete key points were summarized into Table 1 as data points for reproducing the experimental records, and the continuous trends were used to plot... Figure 2 .

[0066] Between 0h and 8h, incision exudate gradually increased, and the dressing remained in place only during the first stage of treatment. At 8h, the impedance measured in the main indicator area decreased to 228Ω, corresponding to... The grayscale value of the verification sub-region is 122, corresponding to Although the main indicator reached the trigger threshold, the verification did not, and the difference between the two was 0.04, which did not constitute a simultaneous threshold exceedance by both channels. Based on this, the nurse determined it to be a false trigger and continued observation, without disabling the second isolation section. This process... Figure 3 The corresponding point is located near the trigger threshold boundary but has not entered the allowed triggering area, thus reflecting the rejection effect of consistency judgment on single-channel threshold crossing cases.

[0067] At 10h, the main indicating impedance further decreased to 204Ω, corresponding to The verification grayscale level increased to 129, corresponding to ,and Consistency is met. The nurse removes the second isolation membrane and activates the second stage; the effective antibacterial dosage is updated to... mg. Upon activation, a lock detection process is initiated immediately, with a preset lock duration. h, during the lock duration, prevents the activation and replacement judgment from being triggered again, and only records no action even if the indicator status is still high. Figure 2 The critical event line at 10h marks the point at which the second segment is activated.

[0068] During the 10-12 hour lockdown period, the indicator value remained high, and the record was made at 11 hours. , The nurse was initially not allowed to trigger the check according to the lockdown rules. After the 12-hour lockdown ended, the nurse was allowed to trigger the check again, but at that time... , The load has fallen below the trigger threshold and is close to the reset threshold range. The system determines that the load has been temporarily relieved and will continue to monitor it. The third stage will not be enabled.

[0069] Between 12 and 24 hours, the patient's nighttime turning over and changes in position led to a renewed increase in exudation. (24-hour reading) , If consistency is satisfied and both channels exceed the trigger threshold, the nurse removes the third isolation section and activates it, updating the effective antibacterial dosage to... mg. After 24 hours, it will enter the 2-hour lockout determination again. After the 26-hour lockout ends, if the indicator does not fall back to the reset threshold, it can still be triggered again, but at this time there will be no unused segments, and subsequent triggers will be used to replace the signal. Figure 2 The activation time of the third segment is marked by the critical event line at 24 hours.

[0070] Read in 36h , If consistency is met and both channels exceed the threshold, the system determines that the threshold has been reached again after all action segments have been activated, generating a replacement signal. The nurse replaces the dressing with a new one after 36.5 hours and completes the record. After replacement, the absorbed fluid volume of the removed dressing is weighed and in vitro antibacterial tests are performed to verify the effectiveness of the segmented activation strategy in optimizing dosage and application sequence. Figure 2 The replacement signal is marked by a critical event line at 36h, thus mapping the replacement logic to threshold-triggered behavior.

[0071] Table 1 shows the reading and action records summarized by key time points. The sampling frequency is consistent between the two tables and is reproducible.

[0072] time th Master Instruction check Are they consistent? Has it been achieved? action 0 0.02 0.01 yes no Only the first section was used for paving. 4 0.45 0.43 yes no Keep 8 0.81 0.77 yes no Accidental triggering was rejected and monitoring continues. 10 0.83 0.83 yes yes Enable the second segment and enter lockout for 2 hours. 11 0.84 0.85 yes yes During the lockout period, triggering is prohibited and only logging is allowed. 12 0.74 0.73 yes no Locking End Recovery Judgment Hold 20 0.78 0.79 yes no Keep 24 0.81 0.82 yes yes Enable the third segment and enter lockout for 2 hours. 26 0.76 0.75 yes no Locking End Hold 36 0.82 0.84 yes yes Once all are activated, a replacement signal is generated when the threshold is reached. 40 0.00 0.00 yes no New dressing replaced, timer reset

[0073] Table 2 shows the effective antibacterial dosage, absorption volume, and in vitro antibacterial results for the phased activation. In vitro antibacterial activity used a mixed bacterial suspension of Staphylococcus aureus ATCC6538 and Escherichia coli ATCC8739, with an initial inoculum volume of... CFU, with a sampling area of ​​10 cm² for each dressing, were incubated at 37°C for 24 hours and the counts were performed and the logarithmic decrease value was calculated.

[0074] Number of segments to enable n mg Aspirated volume QmL 24-hour colony count (CFU) logreduction 1 8 4.8 0.62 2 14 7.9 1.74 3 20 10.6 3.19

[0075] To quantify the correlation between the time to first threshold and the indication signal, a continuous model of aspirated volume versus time was established. ,in mL, Set the trigger threshold for liquid aspiration. If mL, then the theoretical time to first reach the trigger threshold is:

[0076]

[0077] Substitute to get h. Figure 2 This indicates that the theoretical first threshold time is consistent with the phenomenon in Table 1 where the main indicator first exceeds the threshold but the verification does not, around 8 hours. This shows that the dual-channel consistency determination can suppress false triggering caused by early single-channel noise and provide a basis for stable triggering at 10 hours.

[0078] Further statistical analysis of the discrete key points for consistency determination shows that the main indicator crossed the trigger threshold 5 times in the key sampling points in Table 1, the dual-channel threshold crossing and consistency conditions were met 4 times, and a single-channel threshold crossing situation similar to 8h occurred once. Figure 3 The constraints of the locking rules should be noted. Although the consistency judgment condition is met at 11h, the activation or replacement is not performed during the locking period, but only recorded. Therefore, the action decision is still subject to the joint constraints of the consistency judgment and the locking rules.

[0079] Furthermore, the antibacterial efficacy was characterized using differential equations to ensure that the bacterial load met the requirements. ,in , Take a piecewise constant that is proportional to the effective antibacterial dosage. , cm². Therefore:

[0080]

[0081] Taking the activation of the second segment at 10 hours and the activation of the third segment at 24 hours as the segmentation points, we have:

[0082]

[0083] correspond CFU, the logarithm decreased by approximately 0.42 over 24 hours. If the second segment is not activated before 24 hours and the first segment is maintained throughout, then... ,correspond CFU, the logarithm decreased by approximately 0.29 over 24 hours. Figure 4 The results showed that segmented activation increased the logarithmic decrease by approximately 0.13 compared to the control at 24 h, indicating that segmented activation increased the... The cumulative effect of the enhanced decay is consistent with the antibacterial enhancement trend brought about by the increase in the number of enabled segments shown in Table 2. At the same time, the main indicator and the verification consistency rule, as well as the trigger reset threshold and the lock duration, jointly suppressed the false triggering at 8h and avoided repeated triggering within the lock period after 10h.

[0084] Example 2:

[0085] The antibacterial dressing is a long, strip-shaped composite dressing with a total size of 120mm × 60mm and an effective contact area of ​​72cm². It consists of two antibacterial segments, Segment A and Segment B, arranged sequentially along the intended penetration direction of the dressing. Both Segment A and Segment B utilize a composite antibacterial layer of silver ion-loaded porous cellulose microparticles and a hydrogel matrix. Segment A has a pre-set antibacterial dose of 10mg, and Segment B has a pre-set antibacterial dose of 10mg. The isolation portion of each segment is divided into a first sub-isolation zone Z1 and a second sub-isolation zone Z2, separated by an independently removable isolation membrane. The isolation membrane employs a double isolation structure formed by a tearable polyethylene film and a dotted heat-sealed boundary, ensuring that removing either sub-isolation zone does not affect the sealing status of the other sub-isolation zone.

[0086] The sub-isolation zones are arranged sequentially along the expected direction of penetration, with Z1 closer to the load status indicator zone and Z2 further away. The load status indicator zone is located at the proximal observation window of the dressing and has a directional arrow pointing in the expected direction of penetration. For segment A, Z1 is located 0mm to 15mm proximal to the indicator zone; for segment A, Z2 is located 15mm to 30mm proximal to the indicator zone; for segment B, Z1 is located 30mm to 45mm proximal to the indicator zone; and for segment B, Z2 is located 45mm to 60mm proximal to the indicator zone. This arrangement prioritizes releasing Z1 closest to the indicator zone to form a proximal antimicrobial barrier upon initial threshold attainment, and subsequently releasing Z2 distally to extend the antimicrobial coverage area upon fulfillment of sequential conditions. Figure 5 The curves showing the position of the infiltration front over time under the diffusion-dominated model are presented, with boundary lines indicating the sequential triggering positions at 15 mm and 23 mm of the boundary of segment A and segment B, respectively, along with the corresponding theoretical arrival times.

[0087] To achieve sequential activation control, sequential trigger markers are set at the Z1 and Z2 boundaries of segment A and segment B, respectively. These sequential trigger markers are variable-state markers, possessing an initial state and a triggered state, with irreversible state changes. The variable-state markers include a liquid absorption trigger layer and a connected color-developing layer at the boundaries. The liquid absorption trigger layer is a fiber paper layer containing superabsorbent resin, and the color-developing layer is a porous coating with a fixed color-developing system. The color-developing system uses a pH-based system formed by bromothymol blue and buffer salt microcapsules; initially, it is light-colored, changing to a blue-green triggered state after liquid absorption and maintaining this state. A one-way barrier structure is set between the liquid absorption trigger layer and the main liquid absorption layer. This one-way barrier structure is formed by a combination of a hydrophobic gradient microporous membrane and a micro-check valve texture, allowing liquid to enter the liquid absorption trigger layer in the direction of the arrow while restricting backflow, thus ensuring that the triggered state is not reset due to liquid backflow.

[0088] The dressing is simultaneously equipped with threshold indicators for the load status indication area. The trigger threshold is set when the indication value reaches 0.80, and the reset threshold is set when the indication value falls back to within 0.65. The indication value I is the comprehensive load indication quantity, which can be obtained by normalizing the grayscale of the observation window or by normalizing the impedance. This embodiment uses the grayscale normalization reading method. The nursing staff reads and records the indication value I every 30 minutes, while observing whether the sequential trigger marker is in the triggered state. Only when the indication value I reaches or exceeds the trigger threshold and the variable status marker of the corresponding segment is in the triggered state and still reaches or exceeds the trigger threshold after the lockout period ends, is it allowed to release the second sub-isolation zone Z2 of that segment. Figure 6 The locked intervals of segment A and segment B, the marked trigger state intervals, and the moment when sampling point I reaches or exceeds 0.80 are shown, visually representing the Z2 release window under the joint constraints of locking determination and sequential triggering.

[0089] The application scenario is the nursing care of sports abrasions in a community sports medicine clinic. A patient suffered an abrasion on the lateral side of their lower leg during soccer training, with exudate flowing downwards due to gravity. At 0h, nursing staff cleaned the wound and applied a dressing, using only segment A and removing only Z1 of segment A, keeping Z2 of segment A separate from Z1 and Z2 of segment B. The nursing staff noticed that the patient had misaligned the dressing with the arrow pointing approximately 90 degrees to the main permeation direction, causing the drainage strip to not align with the preset main permeation direction. The dressing was then rotated and adjusted to align the direction arrow with the main permeation direction before being reapplied, ensuring the permeation front advanced in the expected direction and was consistent with the spatial position of the sequential trigger marker.

[0090] Between 0h and 2h, wound exudation gradually increases, and the indicator value I rises, reaching 0.82 at 2h, meeting the trigger threshold. At this time, the variable state flag corresponding to segment A is still in the initial state, indicating that the main aspirating layer's penetration front has not yet reached the Z1 and Z2 boundaries of segment A. Based on this, nursing staff only keep segment A's Z1 in the enabled state and are not allowed to deactivate segment A's Z2. After the nursing staff performs the first deactivation of segment A's Z1 at 2h, a lockout judgment is entered, with the lockout duration set to 6h. During the lockout duration, deactivation of segment A's Z2 is prohibited, and even if the indicator value I remains high, only inaction is recorded. Figure 6 The comparison between the locking interval of the middle segment A from 2h to 8h and the starting time of the marked trigger state of segment A shows that the locking determination can prevent premature release before the infiltration front crosses the boundary.

[0091] During the 2-8 hour lockdown period, the indicator value I fluctuated between 0.76 and 0.79. At 6 hours, the indicator value I was 0.78, still close to the trigger threshold, but because the lockdown had not yet ended, deactivating Z2 in segment A was still prohibited. At 8 hours, the lockdown ended, and the indicator value I was 0.81, still reaching the trigger threshold. Moreover, the variable state marker at the boundary of segment A had irreversibly changed from the initial state to the triggered state. Based on this, the nursing staff deactivated Z2 in segment A to enable the remaining dose, completing the upgrade of segment A from partial activation to full activation. Figure 5 The theoretical time for the infiltration front to reach the boundary of segment A is approximately 7.61 hours, which corresponds to the 8-hour trigger state in Table 3, supporting the arrival determination of the sequential trigger marker.

[0092] Between 8 and 12 hours, after full activation of Segment A, a wider antimicrobial coverage zone is formed, and the indicator value I drops back to around 0.70. At 12 hours, the indicator value I rises again to 0.82, and the nursing staff determines that the next stage of load increase has begun. Segment B's Z1 is deactivated to activate the first dose portion of Segment B, and the 6-hour lockout is re-entered. During the 12-18 hour lockout period, even if the indicator value I reaches 0.79 at 16 hours and continues to rise, deactivation of Segment B's Z2 is still prohibited. At the end of the 18-hour lockout, the indicator value I is 0.81, still reaching the trigger threshold, and the variable status marker at the Segment B boundary is in the triggered state. The nursing staff deactivates Segment B's Z2 to activate the remaining dose portion of Segment B, completing full activation of Segment B. Figure 5 The theoretical time for the penetration front to reach the boundary of segment B is approximately 17.89 hours, which corresponds to the 18-hour trigger state in Table 3, supporting the coupled logic of secondary triggering and sequential triggering.

[0093] After both segments A and B were fully activated, the nursing staff continued to read the indicator value I at the same sampling frequency. At 30 hours, the indicator value I reached 0.83 again, triggering the threshold. Since both segments were fully activated, the system generated a replacement signal. At 30.5 hours, the nursing staff replaced the dressing with a new one and recorded the amount of absorbent material and the antibacterial test results of the removed dressing to verify the effectiveness of the graded release and sequential triggering strategy.

[0094] Table 3 shows the recorded data consistent with the triggering logic described above. The permeation amount Q is the result of weighing and converting the same batch of materials removed from the table. The location of the permeation front is also shown. To determine the location of the main absorption layer permeation front calculated based on the diffusion-dominant model, the marked states of segment A and segment B represent the initial or triggered states of the variable state markers at the corresponding boundaries, respectively.

[0095] Time t (unit: h) Exudate volume Q (unit: mL) Penetration Front Unit mm Indicator value I Segment A marking status Segment B marking status action 0 0.0 0.00 0.20 initial initial Apply and correct arrow direction, only enable segment A and only deactivate segment A's Z1. 1 1.2 5.44 0.55 initial initial Keep 2 2.8 7.69 0.82 initial initial The threshold is reached and the marker does not trigger the release segment A in Z1, and the lock is entered for 6 hours, prohibiting the release segment A in Z2. 4 4.5 10.88 0.76 initial initial During the lockout period, Z2 of segment A cannot be released. 6 5.8 13.33 0.78 initial initial During the lockout period, Z2 of segment A cannot be released. 8 7.0 15.39 0.81 trigger initial The lock ended but the threshold was still reached, and the trigger for releasing segment A was marked in Z2. 10 7.8 17.19 0.70 trigger initial Keep 12 8.6 18.84 0.82 trigger initial Reaching the threshold release segment B's Z1 and entering the locked state for 6 hours prohibiting the release segment B's Z2. 16 9.8 21.77 0.79 trigger initial During the lockout period, Z2 of segment B is prohibited from being released. 18 10.5 23.07 0.81 trigger trigger The lock ended but the threshold was still reached, and the trigger for release segment B was marked as Z2. 22 11.2 25.52 0.72 trigger trigger Keep 30 12.4 29.78 0.83 trigger trigger Once all are activated, a replacement signal is generated when the threshold is reached.

[0096] Table 4 presents the key points of the graded release dose, in vitro release curves, and antibacterial data. The release curves were measured in phosphate buffer at 37°C. t50 and t90 represent the times required for cumulative release to reach 50% and 90%, respectively. The antibacterial test used a mixed culture of Staphylococcus aureus and Escherichia coli, with an initial inoculum size of [missing data]. CFU were counted and the logarithmic decrease was calculated after 24 hours. The control group was a non-fractionated single-release group with the same total dose as the fractionated group, but without distinction between Z1 and Z2. Figure 7 The logarithmic decrease of the fractionated release unit and the t50 and t90 were compared side-by-side to demonstrate the effect of fractionated release on antibacterial results and release rhythm.

[0097] Release unit Graded dosage unit mg t50 units h t90 units h 24-hour colony count (CFU) Logarithmic decrease Z1 of segment A 4 0.6 2.0 2.40 Z2 of segment A 6 3.5 8.0 3.05 Z1 of segment B 4 1.2 3.5 2.60 Z2 of segment B 6 5.0 12.0 3.22 Ungraded control group, total dose 20 mg 20 0.8 4.0 2.60

[0098] Combining Tables 3 and 4, the relationship between release and osmosis can be described in words, including the location of the osmosis front of the main absorbent layer. Approximate with time It is proportional and crosses the boundaries of segment A and segment B near 8h and 18h ​​respectively, thereby triggering the variable state flag to change from the initial state to the triggered state. The indicator value I shows an alternating process of step relief and re-rise when Z1 and Z2 are released, reflecting the phased buffering effect of graded activation on the load. Figure 7 The mean logarithmic decrease of the graded release unit over 24 hours was approximately 2.82, compared to 2.60 for the ungraded control, representing an increase of approximately 0.22. This indicates that graded release can improve the average level of antibacterial performance at the same total dose.

[0099] To validate the sequence of trigger marker positions and locking duration, this embodiment establishes a diffusion-dominated permeation front propagation model. The main adsorption layer is equivalent to a one-dimensional diffusion medium, and the concentration of the permeation marker satisfies the diffusion equation:

[0100]

[0101] Under the boundary condition that the proximal supply concentration is... In this case, its analytical solution can be written as:

[0102]

[0103] Penetration Frontier satisfy ,make Then we have:

[0104]

[0105] D=9 Every hour and ,

[0106]

[0107] Segment A boundary sequence trigger mark position acquisition mm, then arrival time:

[0108]

[0109] Segment B boundary sequence trigger mark position acquisition mm, then arrival time:

[0110]

[0111] With a lock duration of 6 hours, we can obtain... and This prevents Z2 from being released prematurely during the lockout period after Z1 is released, and Z2 is only released when the threshold is reached after the lockout ends and the flag trigger state is met at the same time, which is consistent with the secondary triggering actions at 8h and 18h ​​in Table 3. Figure 6 Further provide the satisfaction The minimum boundary position of the condition is:

[0112]

[0113] Segment A is designed with a 15mm margin for safety, while segment B is designed with a 23mm margin to release subsequent doses when the load accumulates at a deeper level, thereby reducing dose waste caused by early one-time release and improving the persistence of antibacterial activity in the later stages.

[0114] In summary, this embodiment achieves graded release by releasing Z1 only upon reaching the threshold for the first time and releasing Z2 upon reaching the threshold for the second time through segmented structures of segments A and B and independent isolation of Z1 and Z2 within each segment; it ensures that the direction of penetration propulsion is consistent with the structural layout through directional markings; it achieves sequential triggering and irreversible determination through variable state markers at the boundaries and unidirectional barrier structures; and it suppresses premature release through locking duration. Thus, it implements the technical solutions of graded activation of sub-isolation zones, arrangement along the propulsion direction, directional alignment, sequential trigger markings, variable state markings, and the combination of the liquid absorption trigger layer and the color development layer to limit backflow.

[0115] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of the present invention as claimed. The scope of protection of this invention is defined by the appended claims and their equivalents.

Claims

1. A method for optimizing the dosage and application sequence of antibacterial dressings, based on an antibacterial dressing with a segmented, operable structure, wherein the dressing includes at least two antibacterial action segments, each segment having a pre-set antibacterial dose and being isolated by a corresponding isolation section, and is equipped with a load status indicator area and a threshold indicator; the method includes: S1. Only the first section is used during installation, and the remaining sections are kept isolated; S2. During use, obtain the indication status of the indicator area and compare it with the threshold; S3. When the threshold is reached, the isolation of the next unused segment is lifted to enable it, so that the effective antibacterial dosage is updated to the sum of the dosages of the already enabled segments; S4. Repeat S2-S3 until all active segments are enabled; S5. When all indicators are enabled, a replacement signal is generated when the threshold is reached again.

2. The method for optimizing the dosage and application sequence of antibacterial dressings according to claim 1, characterized in that... The load status indication area includes a main indication sub-area and a verification sub-area; in step S2, the indication status of the two are obtained respectively and a consistency judgment is performed; only when both reach or exceed the threshold and the consistency is established, S3 or S5 is executed, otherwise S2 is continued.

3. The method for optimizing the dosage and application sequence of antibacterial dressings according to claim 1, characterized in that... The threshold identifier includes a trigger threshold and a reset threshold, and the reset threshold is lower than the trigger threshold. After the next segment is enabled in step S3, step S2 will only allow the determination to be triggered again if the indicated state falls back to within the reset threshold or after a preset locking time.

4. The method for optimizing the dosage and application sequence of antibacterial dressings according to claim 1, characterized in that... Each of the antibacterial action segments is divided into at least two independently releasable sub-isolation zones; in step S3, when the threshold is reached for the first time, only the first sub-isolation zone is released to enable the first dose portion; when the threshold is reached again in the partially enabled state of the segment, the second sub-isolation zone is released to enable the remaining dose portion.

5. The method for optimizing the dosage and application sequence of antibacterial dressings according to claim 4, characterized in that... The sub-isolation zones are arranged sequentially along the expected advance direction of the penetration front, such that the first sub-isolation zone corresponds to the area close to the load status indicator area and the second sub-isolation zone corresponds to the area far away from the load status indicator area; in step S3, the corresponding sub-isolation zones are released according to the arrangement order.

6. The method for optimizing the dosage and application sequence of antibacterial dressings according to claim 4, characterized in that... After the first sub-isolation zone is released for the first time, a lock determination is entered. The release of the second sub-isolation zone is prohibited within a preset lock duration. The second sub-isolation zone is released to enable the remaining dose portion only if the indication state of the load status indicator zone still reaches or exceeds the threshold after the lock duration ends.

7. The method for optimizing the dosage and application sequence of antibacterial dressings according to claim 5, characterized in that... The load status indication area is provided with a direction mark consistent with the expected direction of advancement; during the laying in step S1, the direction mark is aligned with the preset main direction of penetration of the target coverage area. If the laying direction is not adjusted according to the criteria, the laying direction will be adjusted accordingly.

8. The method for optimizing the dosage and application sequence of antibacterial dressings according to claim 5, characterized in that... A sequential trigger mark is set at the boundary between the first sub-isolation zone and the second sub-isolation zone; when the indication status is obtained in step S2, it is determined whether the penetration front reaches the sequential trigger mark; the second sub-isolation zone is allowed to be released only when the penetration front reaches the sequential trigger mark, otherwise the first sub-isolation zone is allowed to be released.

9. The method for optimizing the dosage and application sequence of antibacterial dressings according to claim 8, characterized in that... The sequential triggering marker is a variable state marker, which includes an initial state and a triggering state; the variable state marker changes from the initial state to the triggering state when the penetration front arrives and remains irreversible; in step S2, whether the variable state marker is in the triggering state is used as the basis for determining whether the target has been reached.

10. The method for optimizing the dosage and application sequence of antibacterial dressings according to claim 9, characterized in that... The variable state marker includes a liquid absorption trigger layer and a communicating color development layer disposed at the boundary between the first sub-isolation zone and the second sub-isolation zone; when the permeation front reaches the liquid absorption trigger layer, the color development layer develops color to form the trigger state, and the liquid absorption trigger layer restricts liquid backflow through unidirectional barrier.

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