Implantable pressure sensor and preparation method and application thereof

By constructing a three-layer structure implantable pressure sensor consisting of zwitterionic conductive hydrogel and microphase-separated copolymer hydrogel, the problems of compatibility and interface stability between implantable devices and biological tissues were solved, realizing an implantable pressure sensor with high sensitivity, long-term stability and biocompatibility, suitable for tissue engineering and physiological signal monitoring.

CN122282173AActive Publication Date: 2026-06-26TIANJIN UNIV
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Patent Information

Application Number
CN202610748100.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-05-28
Publication Date
2026-06-26
Estimated Expiration
2046-05-28

AI Technical Summary

Technical Problem

Existing implantable device materials differ significantly from biological soft tissues, which can easily lead to stress concentration, frictional stimulation, chronic inflammation, and signal distortion. Furthermore, the interfacial bonding stability is insufficient, making it difficult to maintain stable operation in complex in vivo environments over the long term.

Method used

An implantable pressure sensor with a three-layer structure was constructed using zwitterionic conductive hydrogel and microphase-separated copolymer hydrogel. Through molecular design and structural optimization, combined with encapsulation with aliphatic polyester materials, biocompatibility, mechanical compatibility and interfacial stability were improved.

Benefits of technology

The sensor exhibits high biocompatibility and adaptability to human soft tissue, reduces interfacial stress and chronic inflammation, demonstrates good long-term stability, high sensing sensitivity, and excellent linear response. It also possesses good in vivo biodegradability, making it suitable for applications in tissue engineering, physiological signal monitoring, and neuromodulation.

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Abstract

The invention belongs to the technical field of biomedical materials and flexible sensing, and particularly relates to an implantable pressure sensor and a preparation method and application thereof. The pressure sensor is of a three-layer parallel plate structure, an electrode layer is conductive hydrogel prepared from polymerizable zwitterionic monomers, a dielectric layer is microphase separation hydrogel formed by copolymerization of acrylamide monomers and acrylate monomers, and a packaging layer is a biocompatible polymer fiber membrane; by regulating and controlling the material composition, the polymerization condition and the structure, the device can be well matched with biological soft tissue in the aspects of water content, tissue adaptability and the like; in the aspect of functional characteristics, the implantable sensor has the advantages of sensitive pressure response, high cycling stability and the like, and can be applied to the fields of tissue engineering, physiological or pathological signal monitoring, nerve stimulation regulation and control, drug delivery and the like.
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