sample analyser
By introducing a transfer container and two independent sample dispensing devices into the sample analyzer, the sample dispensing process is decoupled, enabling efficient, accurate, and miniaturized sample dispensing and detection.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SHENZHEN MINDRAY BIO MEDICAL ELECTRONICS CO LTD
- Filing Date
- 2024-12-25
- Publication Date
- 2026-06-26
AI Technical Summary
In existing sample analyzers, when two sample needles are used together to perform sample dispensing, it is difficult to balance the accuracy of the test results and the miniaturization of the instrument. Furthermore, existing solutions have the risk of air bubbles or limitations on the movement path.
The system employs a transfer container and two independent sample distribution devices. The first sample distribution device collects samples from the sample container and transfers them to the transfer container, while the second sample distribution device extracts samples from the transfer container and distributes them to the detection carrier. The transfer paths are spaced apart to avoid crossover, thus achieving decoupling of sample distribution.
It improves sample distribution and detection efficiency, eliminates the risk of air bubbles, ensures the accuracy of test results, and contributes to the miniaturization design of sample analyzers.
Smart Images

Figure CN122283111A_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of medical devices, and more particularly to a sample analyzer. Background Technology
[0002] A sample analyzer provided by related technology needs to perform the following sample dispensing actions: collecting samples from a sample container and dispensing the collected samples into the detection carrier. In this scheme, the actions of collecting samples from the sample container and dispensing the collected samples into the detection carrier are both performed by the same sample needle. Within one working cycle, this sample needle must sequentially perform the actions of collecting samples from the sample container, dispensing the collected samples into the detection carrier, and cleaning the inner and outer walls of the needle. This results in a long completion time for the entire working cycle of the sample needle, thus leading to a long detection cycle for the entire testing project and severely impacting the efficiency of the sample analyzer.
[0003] To address the aforementioned issues, relevant technical personnel further proposed a design scheme involving two sample needles: one sample needle (e.g., a sampling needle) is used to extract the sample from the sample container, and another sample needle (e.g., a spotting needle) is used to dispense the sample onto the color patch of the dry chemical detection carrier or dispense it into the formed element detection carrier. Among these, there are two methods for the sampling needle to deliver the sample to the spotting needle: tubing and needle-based. However, both methods have shortcomings in practical applications, specifically: (1) The tubing method uses a liquid-driven unit to directly deliver the sample from the sampling needle to the spotting needle through a tubing connecting the two sample needles. This method carries the risk of generating air bubbles, which can affect the sample detection results. (2) The needle-based method first dispenses the sample from the sampling needle into a container, and then the spotting needle removes the sample from this container. The movement paths of the sampling needle and the spotting needle in the needle-based method are designed with overlapping areas to ensure that both the sampling needle and the spotting needle can move to the location of the container. This greatly limits the overall layout, resulting in a larger size for the sample analyzer. Summary of the Invention
[0004] The first objective of this invention is to provide a sample analyzer that addresses the technical problem in related technologies where using two sample needles to perform sample dispensing operations makes it difficult to balance the accuracy of detection results with miniaturization.
[0005] To achieve the above objectives, the present invention provides a sample analyzer, comprising:
[0006] Transit container;
[0007] A first sample distribution device is configured to collect at least a portion of the samples from a sample container, move the collected samples along a first transfer path to the transfer container, and distribute all or part of the collected samples into the transfer container.
[0008] The second sample dispensing device is set independently of the first sample dispensing device, and the second sample dispensing device is used to draw at least a portion of the sample that was dispensed to the transfer container by the first sample dispensing device from the transfer container, and to move the drawn sample along the second transfer path to the sample dispensing position, and to dispense all or part of the drawn sample into the detection carrier located at the sample dispensing position;
[0009] A detection device for detecting a sample dispensed into the detection carrier by the second sample dispensing device;
[0010] A controller, wherein the controller is at least used to control the operation of the first sample dispensing device, the second sample dispensing device, and the detection device;
[0011] The first transfer path and the second transfer path are set at intervals.
[0012] In one embodiment, the sample analyzer further includes a sample introduction device, which is used to drive the sample container containing the sample to be transported along the sample introduction direction to the sampling position;
[0013] In the injection direction, the first transfer path and the second transfer path are spaced apart.
[0014] In one implementation, the second transfer path and the first transfer path are arranged sequentially in the injection direction.
[0015] In one implementation, the first transfer path includes a first horizontal movement path, and the second transfer path includes a second horizontal movement path;
[0016] The first horizontal movement path and the second horizontal movement path are spaced apart and parallel, and / or both the first horizontal movement path and the second horizontal movement path are perpendicular to the injection direction.
[0017] In one implementation, the first transfer path includes a first horizontal movement path, and the second transfer path includes a second horizontal movement path;
[0018] The first horizontal movement path and the second horizontal movement path are spaced apart and not parallel; and / or, the first horizontal movement path is set at an angle greater than 0° and less than 90° relative to the injection direction, and the second horizontal movement path is perpendicular to the injection direction.
[0019] In one implementation, the number of transfer containers is one, and the sample analyzer further includes a first driving device, which is used to drive the transfer container to move between a first transfer position and a second transfer position;
[0020] The first sample allocation device allocates all or part of the collected samples to the transfer container, including: the first sample allocation device allocates all or part of the collected samples to the transfer container located at the first transfer position;
[0021] The second sample dispensing device draws at least a portion of the sample that was dispensed to the transfer container by the first sample dispensing device from the transfer container, including: the second sample dispensing device draws at least a portion of the sample that was dispensed to the transfer container by the first sample dispensing device from the transfer container located at the second transfer position.
[0022] In one embodiment, the first driving device is used to drive the transfer container to move horizontally in a straight line or curve back and forth between the first transfer position and the second transfer position;
[0023] Alternatively, the first driving device is used to drive the transfer container to rotate horizontally between the first transfer position and the second transfer position.
[0024] In one embodiment, the number of the transfer container is one, the transfer container is a fixed and non-movable container, and the transfer container has an inner cavity, a discharge port and a suction port, the discharge port and the suction port are spaced apart on the top of the transfer container and are respectively connected to the inner cavity;
[0025] The first sample distribution device distributes all or part of the collected samples into the transfer container, including: the first sample distribution device distributes all or part of the collected samples into the transfer container through the discharge port;
[0026] The second sample dispensing device aspirates at least a portion of the sample that was dispensed into the transfer container by the first sample dispensing device from the transfer container, including: the second sample dispensing device aspirates at least a portion of the sample that was dispensed into the transfer container by the first sample dispensing device from the transfer container through the sampling port.
[0027] In one embodiment, the inner cavity includes a first sub-cavity, a second sub-cavity, and a third sub-cavity, wherein the first sub-cavity extends vertically downward from the sample suction port, and the second sub-cavity extends vertically downward from the sample discharge port;
[0028] The first sub-cavity extends vertically downward from the sampling port to a greater depth than the second sub-cavity extends vertically downward from the discharge port, and the third sub-cavity extends obliquely from the bottom of the second sub-cavity to the first sub-cavity; or, the first sub-cavity extends vertically downward from the sampling port to a depth equal to the second sub-cavity extends vertically downward from the discharge port, and the third sub-cavity extends horizontally from the bottom of the second sub-cavity to the bottom of the first sub-cavity.
[0029] In one implementation, there are multiple transit containers, including a first transit container and a second transit container, which are independently configured.
[0030] The first sample allocation device allocates all or part of the collected samples to the transfer container, including: the first sample allocation device allocates all or part of the collected samples to the first transfer container;
[0031] The sample analyzer further includes a transfer fluid path, which is connected between the first transfer container and the second transfer container. The transfer fluid path is used to transport all or part of the sample, which is at least partially dispensed to the first transfer container by the first sample dispensing device, to the second transfer container.
[0032] The second sample dispensing device draws at least a portion of the sample that was dispensed to the transfer container by the first sample dispensing device from the transfer container, including: the second sample dispensing device draws at least a portion of the sample that was dispensed to the transfer container by the first sample dispensing device from the second transfer container.
[0033] In one implementation, there are multiple transit containers, including a third transit container and a fourth transit container, which are independently configured.
[0034] The sample analyzer further includes a first driving device and a second driving device. The first driving device is used to drive the third transfer container to move between the first transfer position and the second transfer position, and the second driving device is used to drive the fourth transfer container to move between the third transfer position and the fourth transfer position.
[0035] The first sample allocation device is used to allocate all or part of the collected samples to the transfer container, including: the first sample allocation device is used to allocate all or part of the collected first samples to the third transfer container located at the first transfer position, and to allocate all or part of the collected second samples to the fourth transfer container located at the third transfer position;
[0036] The second sample dispensing device is used to draw at least a portion of the sample that was dispensed to the transfer container by the first sample dispensing device from the transfer container, including: the second sample dispensing device is used to draw at least a portion of the first sample that was dispensed to the third transfer container by the first sample dispensing device from the third transfer container located at the second transfer position, and is used to draw at least a portion of the second sample that was dispensed to the fourth transfer container by the first sample dispensing device from the fourth transfer container located at the fourth transfer position;
[0037] The first sample and the second sample are two different types of body fluid samples.
[0038] In one implementation, the first driving device and the second driving device are independently configured. The first driving device is used to drive the third transfer container to move horizontally and linearly back and forth between the first transfer position and the second transfer position. The second driving device is used to drive the fourth transfer container to move horizontally and linearly back and forth between the third transfer position and the fourth transfer position.
[0039] Alternatively, the first driving device and the second driving device are set independently of each other. The first driving device is used to drive the third transfer container to move back and forth in a curve between the first transfer position and the second transfer position, and the second driving device is used to drive the fourth transfer container to move back and forth in a curve between the third transfer position and the fourth transfer position.
[0040] Alternatively, the first driving device and the second driving device are the same driving device, which is used to drive the third transfer container and the fourth transfer container to rotate, so that the third transfer container rotates horizontally between the first transfer position and the second transfer position, and so that the fourth transfer container rotates horizontally between the third transfer position and the fourth transfer position.
[0041] In one embodiment, the sample analyzer further includes a reagent dispensing device;
[0042] The controller is configured to: upon receiving a detection instruction for the first sample, control the first sample dispensing device to collect at least a portion of the first sample from a first sample container containing the first sample; control the first sample dispensing device to move the collected first sample along the first transfer path to the third transfer container located at the first transfer position; control the first sample dispensing device to allocate all or part of the collected first sample to the third transfer container located at the first transfer position; control the first driving device to drive the third transfer container containing the first sample from the first transfer position to the second transfer position; control the second sample dispensing device to extract at least a portion of the first sample allocated to the third transfer container by the first sample dispensing device from the third transfer container located at the second transfer position; control the second sample dispensing device to move the extracted first sample along the second transfer path to the sample loading position; control the second sample dispensing device to allocate all or part of the extracted first sample to a first detection carrier located at the sample loading position; and control the detection device to detect the first sample allocated to the first detection carrier by the second sample dispensing device.
[0043] The controller is also configured to:
[0044] Upon receiving a detection command for the second sample, the reagent dispensing device is controlled to dispense staining reagent into a second sample container containing the second sample. The first sample dispensing device is controlled to draw at least a portion of a first mixture formed by mixing the second sample and the staining reagent from the second sample container. The first sample dispensing device is controlled to move the drawn first mixture along the first transfer path to a fourth transfer container located at the third transfer position. The first sample dispensing device then dispenses all or part of the drawn first mixture into the fourth transfer container located at the third transfer position. The second driving device is controlled to drive the container containing the first mixture... The fourth transfer container of the mixture moves from the third transfer position to the fourth transfer position, controls the second sample dispensing device to draw at least a portion of the first mixture that was dispensed to the fourth transfer container by the first sample dispensing device from the fourth transfer container located at the fourth transfer position, controls the second sample dispensing device to move the drawn first mixture along the second transfer path to the sample dispensing position, controls the second sample dispensing device to dispense all or part of the drawn first mixture into the second detection carrier located at the sample dispensing position, and controls the detection device to detect the first mixture dispensed by the second sample dispensing device into the second detection carrier;
[0045] Alternatively, upon receiving a detection command for the second sample, the system controls the first sample dispensing device to collect at least a portion of the second sample from the second sample container containing the second sample and to dispense all or part of the collected second sample into the staining pool; controls the reagent dispensing device to dispense staining reagent into the staining pool; controls the first sample dispensing device to draw at least a portion of the first mixture formed by mixing the second sample and the staining reagent from the staining pool; controls the first sample dispensing device to move the drawn first mixture along the first transfer path to the fourth transfer container located at the third transfer position; and controls the first sample dispensing device to dispense all or part of the drawn first mixture into the fourth transfer container located at the third transfer position. In the four transfer containers, the second driving device is controlled to drive the fourth transfer container containing the first mixture to move from the third transfer position to the fourth transfer position; the second sample dispensing device is controlled to draw at least a portion of the first mixture dispensed by the first sample dispensing device to the fourth transfer container located at the fourth transfer position; the second sample dispensing device is controlled to move the drawn first mixture along the second transfer path to the sample dispensing position; the second sample dispensing device is controlled to dispense all or part of the drawn first mixture into the second detection carrier located at the sample dispensing position; and the detection device is controlled to detect the first mixture dispensed by the second sample dispensing device into the second detection carrier.
[0046] Alternatively, upon receiving a detection command for the second sample, the first sample dispensing device is controlled to collect at least a portion of the second sample from a second sample container containing the second sample; the first sample dispensing device is controlled to move the collected second sample along the first transfer path to the fourth transfer container located at the third transfer position; the first sample dispensing device distributes all or part of the collected second sample into the fourth transfer container located at the third transfer position; the reagent dispensing device distributes staining reagent into the fourth transfer container located at the third transfer position; and the second driving device is controlled to drive a container loaded with a mixture of the second sample and the staining reagent. The fourth transfer container of the first mixture is moved from the third transfer position to the fourth transfer position. The second sample dispensing device is controlled to draw at least a portion of the first mixture formed by mixing the second sample and the staining reagent from the fourth transfer container located at the fourth transfer position. The second sample dispensing device is controlled to move the drawn first mixture along the second transfer path to the sample dispensing position. The second sample dispensing device is controlled to dispense all or part of the drawn first mixture into the second detection carrier located at the sample dispensing position. The detection device is controlled to detect the first mixture dispensed by the second sample dispensing device into the second detection carrier.
[0047] The first sample container and the second sample container are two independent sample containers;
[0048] The first detection vehicle and the second detection vehicle are two independent vehicles.
[0049] In one embodiment, the first sample dispensing device includes a first sample needle, which is a needle with puncture function; the second sample dispensing device includes a second sample needle, which is a needle without puncture function.
[0050] And / or, the sample analyzer further includes a physical detection device, wherein the first sample dispensing device includes a first sample needle, a sampling tube connected to the first sample needle, and a first suction and discharge power component connected to the sampling tube, wherein a portion of the sampling tube forms a physical property detection tube section; the first suction and discharge power component is used to drive the first sample needle to draw at least a portion of the sample from the sample container and to drive a portion of the sample drawn by the first sample needle to move to the physical property detection tube section, and the physical detection device is used to perform physical property detection on the first sample located in the physical property detection tube section.
[0051] In one embodiment, the detection device includes a dry chemical detection device and a formed element detection device;
[0052] The second sample dispensing device is used to dispense all or part of the aspirated sample onto the dry chemical detection carrier located at the first sample dispensing position and / or onto the formed element detection carrier located at the second sample dispensing position;
[0053] The dry chemistry detection device is used to perform dry chemistry detection on the sample dispensed by the second sample dispensing device onto the dry chemistry detection carrier;
[0054] The formed element detection device is used to perform formed element detection on the sample that is dispensed to the formed element detection carrier by the second sample dispensing device;
[0055] The second transfer path includes a second horizontal movement path, and the first and second sample application positions are distributed at intervals along the second horizontal movement path.
[0056] In one embodiment, the dry chemical detection carrier is a test strip, and the dry chemical detection device includes a test strip storage component, a test strip scheduling component, a test strip transmission component, and a result acquisition component. The test strip storage component stores the test strips. The test strip scheduling component schedules the test strips from the test strip storage component to the test strip transmission component along a first conveying direction. The test strip transmission component transmits the test strips to a first sample application position. A second sample dispensing device distributes all or part of the aspirated sample onto the test strip located at the first sample application position. The test strip transmission component also transmits the sampled test strips sequentially along the first conveying direction to a reaction position and a result acquisition position. The result acquisition component acquires the reaction result information of the sample on the test strip at the result acquisition position. The controller also obtains the chemical analysis result of the sample based on the reaction result information fed back by the result acquisition component.
[0057] The formed element detection carrier is a detection box with a cavity for containing the sample. The formed element detection device includes a carrier supply component, a carrier transmission component, and a formed element detection component. The carrier supply component supplies the detection box. The carrier transmission component transports the detection box from the carrier supply component to a second sample dispensing position along a second conveying direction. The second sample dispensing device dispenses all or part of the aspirated sample onto the detection box located at the second sample dispensing position. The carrier transmission component also transports the sampled detection box to the detection position along the second conveying direction. The formed element detection component performs formed element detection on the sample in the detection box located at the detection position. The controller outputs the analysis results of at least some of the formed elements in the sample based on the detection data obtained by the formed element detection component performing formed element detection on the sample.
[0058] The sample analyzer also includes a sample introduction device, which is used to drive the sample container containing the sample to be transported to the sampling position along the sample introduction direction;
[0059] The first conveying direction, the second conveying direction, and the sample injection direction are approximately parallel.
[0060] In one implementation, the first conveying direction, the second conveying direction, and the sample feeding direction are all approximately perpendicular to the second horizontal movement path;
[0061] And / or, in the direction of the second horizontal moving path, the sample introduction device, the first sample application position, and the second sample application position are arranged sequentially.
[0062] In one embodiment, the sample introduction device includes a loading area, an unloading area, and a sample scheduling component. The sample scheduling component is used to transport a sample container loaded with the sample from the loading area toward the unloading area along the sample introduction direction.
[0063] The test strip storage component, the carrier supply component, and the loading area are located on the same side near the sample analyzer.
[0064] In one embodiment, the dry chemical detection device further includes a first recovery component, and the test strip transmission component is further used to transmit the test strip, after acquiring the reaction result information, along the first conveying direction to the first recovery component;
[0065] The formed element detection device further includes a second recycling component, and the carrier conveying component is also used to convey the detection box after the formed element detection is completed to the second recycling component along the second conveying direction;
[0066] The first recycling component and the test strip storage component are respectively arranged close to opposite sides of the sample analyzer along the first conveying direction;
[0067] The second recovery component and the carrier supply component are respectively arranged close to opposite sides of the sample analyzer along the second conveying direction;
[0068] The first recycling component and the second recycling component are either the same recycling component or two independently configured recycling components.
[0069] In one embodiment, the detection device includes a dry chemistry detection device and a formed element detection device; the second sample dispensing device is used to dispense all or part of the aspirated sample into a dry chemistry detection carrier located at a first sample dispensing position; the sample analyzer further includes a third sample dispensing device, which is set independently of the first sample dispensing device and the second sample dispensing device, and is used to aspirate at least a portion of the sample dispensed by the first sample dispensing device into the transfer container from the transfer container, and move the aspirated sample along a third transfer path to a second sample dispensing position, and dispense all or part of the aspirated sample into a formed element detection carrier located at the second sample dispensing position; the dry chemistry detection device is used to perform dry chemistry detection on the sample dispensed by the second sample dispensing device into the dry chemistry detection carrier; the formed element detection device is used to perform formed element detection on the sample dispensed by the third sample dispensing device into the formed element detection carrier; the first transfer path, the second transfer path, and the third transfer path are arranged at intervals, or the first transfer path, the second transfer path, and the third transfer path are arranged at intersections;
[0070] Alternatively, the detection device includes a dry chemistry detection device; the second sample dispensing device is used to dispense all or part of the aspirated sample into a dry chemistry detection carrier located at a first sample dispensing position; the dry chemistry detection device is used to perform dry chemistry detection on the sample dispensed into the dry chemistry detection carrier by the second sample dispensing device;
[0071] Alternatively, the detection device includes a formed element detection device; the second sample dispensing device is used to dispense all or part of the aspirated sample into a formed element detection carrier located at the second sample dispensing position;
[0072] The formed element detection device is used to perform formed element detection on the sample allocated to the formed element detection carrier by the third sample allocation device.
[0073] In one embodiment, the sample analyzer further includes a first cleaning device and a second cleaning device. The first cleaning device is used to perform a cleaning action on the first sample dispensing device located at a first cleaning position. The first sample dispensing device is used to collect at least a portion of the sample from the sample container located at the sampling position. The first cleaning position is located between the sampling position and the transfer container along the first transfer path. The second cleaning device is used to perform a cleaning action on the second sample dispensing device located at a second cleaning position. The second cleaning position is located between the transfer container and the sample application position along the second transfer path.
[0074] And / or, the sample analyzer further includes a first driving device and a third cleaning device, wherein the first driving device is used to drive the transfer container to move between a first transfer position and a second transfer position; the first sample dispensing device is used to dispense all or part of the collected sample into the transfer container located at the first transfer position; the second sample dispensing device is used to aspirate at least a portion of the sample dispensed by the first sample dispensing device into the transfer container from the transfer container located at the second transfer position; and the third cleaning device is used to perform a cleaning action on the transfer container located at the second transfer position, or on the transfer container located at the first transfer position, or on the transfer container moving from the second transfer position toward the first transfer position.
[0075] A second objective of the present invention is to provide a sample analyzer comprising: a transfer container;
[0076] A first sample allocation device is configured to collect at least a portion of the samples from a sample container located at a sampling position and allocate all or part of the collected samples to the transfer container;
[0077] The second sample dispensing device is set independently of the first sample dispensing device, and the second sample dispensing device is used to aspirate at least a portion of the sample that has been dispensed into the transfer container by the first sample dispensing device from the transfer container, and to move the aspirated sample along a second transfer path to the first sample dispensing position and / or the second sample dispensing position, and to dispense all or part of the aspirated sample into the dry chemical detection carrier located at the first sample dispensing position and / or the formed element detection carrier located at the second sample dispensing position;
[0078] A dry chemical detection device, the dry chemical detection device being used to perform dry chemical detection on the sample dispensed by the second sample dispensing device to the dry chemical detection carrier;
[0079] A formed element detection device, wherein the formed element detection device is used to perform formed element detection on the sample dispensed by the second sample dispensing device to the formed element detection carrier;
[0080] A controller, wherein the controller is at least used to control the operation of the first sample dispensing device, the second sample dispensing device, the dry chemical detection device, and the formed element detection device;
[0081] The sampling bits and the second transfer path are set at intervals.
[0082] In one embodiment, the first sample dispensing device includes a first sample needle, a sampling tubing connected to the first sample needle, and a first suction-dispensing power component connected to the sampling tubing. The first suction-dispensing power component is used to drive the first sample needle to collect at least a portion of the sample from the sample container located at the sampling position, and to drive the first sample needle to dispense all or part of the collected sample into the transfer container. The second sample dispensing device includes a second sample needle, a suction tubing connected to the second sample needle, and a second suction-dispensing power component connected to the suction tubing. The second suction-dispensing power component is used to drive the second sample needle to aspirate at least a portion of the sample dispensed to the transfer container by the first sample dispensing device from the transfer container, and to drive the second sample needle to dispense all or part of the aspirated sample into a dry chemical detection carrier and / or a formed element detection carrier.
[0083] Alternatively, the first sample dispensing device includes a first sample needle, a sampling tubing connected to the first sample needle, and a first suction-dispensing power component connected to the sampling tubing. The sampling tubing is also connected to the transfer container. The first suction-dispensing power component is used to drive the first sample needle to collect at least a portion of the sample from the sample container located at the sampling position, and to drive the sampling tubing to dispense all or part of the sample collected by the first sample needle into the transfer container. The second sample dispensing device includes a second sample needle, a suction tubing connected to the second sample needle, and a second suction-dispensing power component connected to the suction tubing. The second suction-dispensing power component is used to drive the second sample needle to draw at least a portion of the sample dispensed to the transfer container by the first sample dispensing device from the transfer container, and to drive the second sample needle to dispense all or part of the drawn sample into a dry chemical detection carrier and / or a formed element detection carrier.
[0084] A third objective of this invention is to provide a sample analyzer comprising:
[0085] Transit container;
[0086] A first driving device is used to drive the transfer container to move between a first transfer position and a second transfer position;
[0087] A first sample distribution device is configured to collect at least a portion of the samples from a sample container and distribute all or part of the collected samples to the transfer container located at the first transfer position;
[0088] A second sample dispensing device is provided independently of the first sample dispensing device, and the second sample dispensing device is used to aspirate at least a portion of the sample that has been dispensed to the transfer container by the first sample dispensing device from the transfer container located at the second transfer position, and to dispense all or part of the aspirated sample to the detection carrier located at the sample dispensing position;
[0089] A detection device for detecting a sample dispensed into the detection carrier by the second sample dispensing device;
[0090] The controller is used to control the operation of the first driving device, the first sample distribution device, the second sample distribution device, and the detection device.
[0091] The sample analyzer provided by this invention, by setting up a transfer container and at least two sample distribution devices (a first sample distribution device and a second sample distribution device), decouples the sampling and sample loading actions. The first sample distribution device first collects at least a portion of the sample from the sample container and distributes the collected sample to the transfer container. Then, the second sample distribution device draws the sample from the transfer container and distributes the drawn sample to the detection carrier. This decouples the sampling and sample loading actions, allowing the first and second sample distribution devices to perform them separately. This shortens the working cycle of both the first and second sample distribution devices, thereby improving the efficiency of batch sample distribution and detection. In this invention, the transfer of samples between the first and second sample distribution devices is achieved through the transfer container. Compared to the pipeline transportation schemes of related technologies, this eliminates the risk of air bubble generation, which helps ensure the accuracy of the sample detection results. Furthermore, by designing the first transfer path of the first sample distribution device and the second transfer path of the second sample distribution device to be spaced apart, that is, the first transfer path of the first sample distribution device and the second transfer path of the second sample distribution device have no overlapping areas, the design of the detection device is not affected by the sampling path of the first sample distribution device. While meeting the accuracy and speed of sample detection results, this invention also facilitates the miniaturization of the sample analyzer and saves space in the department. Attached Figure Description
[0092] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on the structures shown in these drawings without creative effort.
[0093] Figure 1 This is a schematic diagram of the structure of a sample analyzer provided in an embodiment of the present invention, which has a first sample distribution device, a second sample distribution device, and a first transfer path and a second transfer path that are parallel to each other.
[0094] Figure 2 yes Figure 1 Schematic diagram of the structure of the dry chemical detection device, the formed element detection device, and the second sample distribution device;
[0095] Figure 3 This is a schematic diagram of the structure of a sample analyzer provided in an embodiment of the present invention, which has a first sample distribution device, a second sample distribution device, and a first transfer path and a second transfer path that are not parallel to each other.
[0096] Figure 4 This is a schematic diagram of a Y-shaped transfer container provided in an embodiment of the present invention;
[0097] Figure 5 This is another schematic diagram of a Y-shaped transfer container provided in an embodiment of the present invention;
[0098] Figure 6 This is a schematic diagram of a U-shaped transfer container provided in an embodiment of the present invention;
[0099] Figure 7 This is a schematic diagram of the structure of a sample analyzer provided in an embodiment of the present invention, which has a first sample distribution device, a second sample distribution device, and a third sample distribution device, and the first transfer path is parallel to the second transfer path and the third transfer path.
[0100] Figure 8 This is a schematic diagram of the structure of a sample analyzer provided in an embodiment of the present invention, which has a first sample allocation device, a second sample allocation device, and a third sample allocation device, and the first transfer path is not parallel to the second transfer path and the third transfer path;
[0101] Figure 9 This is a schematic diagram of the structure of a sample analyzer having a first sample distribution device, a second sample distribution device, a first transfer container, and a second transfer container, provided in an embodiment of the present invention;
[0102] Figure 10This is a schematic diagram of the structure of a sample analyzer having a first sample distribution device, a second sample distribution device, a third transfer container, and a fourth transfer container, provided in an embodiment of the present invention.
[0103] Reference numerals: 10, Sample analyzer; 100, Transfer container; 110, First transfer container; 120, Second transfer container; 130, Third transfer container; 140, Fourth transfer container; 150, Inner cavity; 151, First sub-cavity; 152, Second sub-cavity; 153, Third sub-cavity; 160, Sample outlet; 170, Sample suction port; 200, First sample dispensing device; 300, Second sample dispensing device; 400, Dry chemical detection device; 410, Test strip storage component; 420, Test strip transfer component; 430, Result acquisition component; 440, First recovery component; 500, Formed element detection device; 510, Carrier supply component; 520, Carrier transfer component; 530, Formed element detection component; 540, Second recovery component; 600, Sample injection device; 610 Loading area; 620 Unloading area; 700 First driving device; 800 Third sample dispensing device; 900 Second driving device; 901 Transfer liquid path; 101 First transfer position; 102 Second transfer position; 103 Sampling position; 104 First sample application position; 105 Second sample application position; 106 Third transfer position; 107 Fourth transfer position; 108 Fifth transfer position; 201 First transfer path; 2011 First horizontal movement path; 202 Second transfer path; 2021 Second horizontal movement path; 203 Third transfer path; 2031 Third horizontal movement path; 20 Sample container; 30 Dry chemical detection carrier; 40 Formed element detection carrier; X1 Sample injection direction; X2 First transport direction; X3 Second transport direction. Detailed Implementation
[0104] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.
[0105] The sample analyzer provided in this embodiment of the invention is suitable for scenarios that require testing samples collected from human or animal bodies and require at least two sample needles for speed improvement.
[0106] like Figures 1 to 10As shown, a sample analyzer 10 provided in a first aspect of the present invention includes a transfer container 100, a first sample dispensing device 200, a second sample dispensing device 300, a detection device, and a controller. The first sample dispensing device 200 is used to collect at least a portion of the sample from the sample container 20 and dispense all or part of the collected sample into the transfer container 100. The second sample dispensing device 300 is set independently of the first sample dispensing device 200; that is, the second sample dispensing device 300 and the first sample dispensing device 200 are not the same sample dispensing device, but two separate sample dispensing devices. The second sample dispensing device 300 is used to aspirate at least a portion of the sample dispensed into the transfer container 100 by the first sample dispensing device 200 from the transfer container 100 and dispense all or part of the aspirated sample into a detection carrier. The detection device is used to detect the sample dispensed into the detection carrier by the second sample dispensing device 300. The controller is used to control the operation of at least the first sample dispensing device 200, the second sample dispensing device 300, and the detection device. The transfer container 100 is mainly used to provide a place for sample transfer. The first sample dispensing device 200 is mainly used to perform sampling operations, that is, to collect samples from the sample container 20 and dispense the samples into the transfer container 100. The second sample dispensing device 300 is mainly used to perform sample addition operations, that is, to draw samples from the transfer container 100 and dispense the samples into the detection carrier. In this implementation scheme, the sample allocation action is decoupled into a sampling action and a sample loading action, which are performed by different sample allocation devices. During the sample allocation action, at least a portion of the sample is first collected from the sample container 20 by the first sample allocation device 200 and allocated to the transfer container 100. Then, the second sample allocation device 300 aspirates the sample from the transfer container 100 and allocates the aspirated sample to the detection carrier. This coordination between the first sample allocation device 200, the second sample allocation device 300, and the transfer container 100 helps to shorten the working cycle of both the first and second sample allocation devices (for clarity, the working cycle of the first sample allocation device 200 can be described as the sampling cycle, and the working cycle of the second sample allocation device 300 as the loading cycle), thereby improving the efficiency of batch sample allocation and detection. Furthermore, using the transfer container 100 for sample transfer, compared to using tubing, eliminates the risk of air bubbles forming in the tubing, thus ensuring the accuracy of the sample detection results.
[0107] In one implementation, the first sample dispensing device 200 is used to collect at least a portion of the sample from the sample container 20, move the collected sample along the first transfer path 201 to the transfer container 100, and dispense all or part of the collected sample into the transfer container 100. The second sample dispensing device 300 is used to aspirate at least a portion of the sample dispensed by the first sample dispensing device 200 from the transfer container 100, move the aspirated sample along the second transfer path 202 to the sample dispensing position, and dispense all or part of the aspirated sample into the detection carrier located at the sample dispensing position. The first transfer path 201 and the second transfer path 202 are spaced apart, meaning they do not overlap or intersect, and the first sample dispensing device 200 and the second sample dispensing device 300 will not move to the same position. This implementation scheme designs the first transfer path 201 of the first sample distribution device 200 and the second transfer path 202 of the second sample distribution device 300 to be spaced apart, which makes the design of the detection device unaffected by the sampling path of the first sample distribution device 200. While meeting the requirements of sample detection accuracy and detection speed, it also facilitates the miniaturization of the sample analyzer 10 and saves space in the department.
[0108] In one implementation, the controller is configured to: control the first sample dispensing device 200 to collect at least a portion of the sample from the sample container 20; control the first sample dispensing device 200 to distribute all or part of the collected sample to the transfer container 100; control the second sample dispensing device 300 to aspirate at least a portion of the sample that was dispensed to the transfer container 100 by the first sample dispensing device 200 from the transfer container 100; and control the second sample dispensing device 300 to distribute all or part of the aspirated sample to the detection carrier.
[0109] In one implementation, the sample analyzer 10 also includes a sample introduction device 600, which drives a sample container 20 containing a sample to be transported along the introduction direction X1 to the sampling position 103. The sample container 20 can be mounted on a sample rack or sample holder, and the sample introduction device 600 drives the sample container 20 to be transported along the introduction direction X1 to the sampling position 103 by driving the sample rack or sample holder. A first sample dispensing device 200 is used to collect samples from the sample container 20 located at the sampling position 103. The sample introduction device 600 is mainly used to realize the automatic sample introduction function for batch samples, without requiring the operator to hold the sample container 20 and place it at the sampling position 103.
[0110] In one implementation, the first transfer path 201 and the second transfer path 202 are spaced apart in the sample injection direction X1, that is, the second transfer path 202 and the first transfer path 201 are arranged one after the other in the sample injection direction X1. This arrangement allows the sample application position and the sampling position 103 of the detection device to be located on the same straight line perpendicular to the sample injection direction X1, meaning the sample application position and the sampling position 103 do not need to be aligned. This ensures that the setting of the detection device is not affected by the sampling position 103 and the first transfer path 201, thereby facilitating the miniaturization design of the sample analyzer 10.
[0111] In one implementation, the second transfer path 202 and the first transfer path 201 are sequentially arranged in the sample introduction direction X1. Since the size of the detection device is fixed, placing the sample application position of the detection device closer to the sample introduction start point of the sample introduction device 600 than the sampling position 103 can help reduce the size of the sample analyzer 10 in the sample introduction direction X1.
[0112] In one implementation, the first transfer path 201 includes a first horizontal movement path 2011, and the second transfer path 202 includes a second horizontal movement path 2021. Both the first sample allocation device 200 and the second sample allocation device 300 have a horizontal movement component.
[0113] In one embodiment of the first horizontal moving path 2011 and the second horizontal moving path 2021, the first horizontal moving path 2011 and the second horizontal moving path 2021 are arranged alternately and parallelly. This arrangement ensures that the first transfer path 201 and the second transfer path 202 will not overlap or intersect, and facilitates the arrangement of the detection device. This parallelism allows for a certain degree of error; for example, the first horizontal moving path 2011 and the second horizontal moving path 2021 can also have a small included angle.
[0114] As a further embodiment of the first implementation of the first horizontal moving path 2011 and the second horizontal moving path 2021 described above, both the first horizontal moving path 2011 and the second horizontal moving path 2021 are perpendicular to the sample injection direction X1. This perpendicularity is permissible with some error; for example, the angle formed by the first horizontal moving path 2011 and the second horizontal moving path 2021 and the sample injection direction X1 can be slightly greater than or slightly less than 90°.
[0115] In a second implementation of the first horizontal movement path 2011 and the second horizontal movement path 2021, the first horizontal movement path 2011 and the second horizontal movement path 2021 are arranged alternately and non-parallel. This arrangement also ensures that the first transfer path 201 and the second transfer path 202 do not overlap or intersect.
[0116] As a further embodiment of the second implementation of the first horizontal moving path 2011 and the second horizontal moving path 2021 described above, the first horizontal moving path 2011 is set at an angle greater than 0° and less than 90° relative to the sample injection direction X1, and the second horizontal moving path 2021 is perpendicular to the sample injection direction X1. The first horizontal moving path 2011 of the first sample dispensing device 200 is set at an angle relative to the sample injection direction X1, and the second horizontal moving path 2021 of the second sample dispensing device 300 is set perpendicular to the sample injection direction X1. This ensures that the first transfer path 201 and the second transfer path 202 do not overlap or intersect, and also facilitates the arrangement of the detection devices.
[0117] In one implementation, the number of transfer containers 100 may be one or more, or two or more.
[0118] In a first embodiment of the transfer container 100, the number of transfer containers 100 is one. The sample analyzer 10 also includes a first driving device 700, which drives the transfer container 100 to move between the first transfer position 101 and the second transfer position 102. The first sample dispensing device 200 dispenses all or part of the collected samples into the transfer container 100, including: the first sample dispensing device 200 dispensing all or part of the collected samples into the transfer container 100 located at the first transfer position 101. The second sample dispensing device 300 aspirates at least a portion of the samples dispensed by the first sample dispensing device 200 into the transfer container 100 from the transfer container 100, including: the second sample dispensing device 300 aspirating at least a portion of the samples dispensed by the first sample dispensing device 200 into the transfer container 100 located at the second transfer position 102. In this embodiment, the transfer container 100 is configured to be movable. This ensures that the working position of the first sample distribution device 200 distributing samples to the transfer container 100 is not the same as the working position of the second sample distribution device 300 absorbing samples from the transfer container 100. As a result, even when the second transfer path 202 of the second sample distribution device 300 is spaced apart from the first transfer path 201 of the first sample distribution device 200, both the second sample distribution device 300 and the first sample distribution device 200 can still interact with the transfer container 100. This guarantees that the first sample distribution device 200 can distribute samples to the transfer container 100, and the second sample distribution device 300 can absorb samples from the transfer container 100. The movable transfer container 100 allows the second sample dispensing device 300 to be free from the first transfer path 201 of the first sample dispensing device 200. This means that the second sample dispensing device 300 does not need to align with the sampling position 103 where the first sample dispensing device 200 collects samples from the sample container 20 when dispensing samples to the detection carrier. This facilitates the setting of the detection device without being affected by the sampling position 103, and thus facilitates the miniaturization design of the sample analyzer 10.
[0119] As a further embodiment of the first implementation of the transfer container 100 described above, the first driving device 700 is used to drive the transfer container 100 to reciprocate horizontally in a straight line or curve between the first transfer position 101 and the second transfer position 102, that is, the first driving device 700 can be a reciprocating push-pull device. Alternatively, as an alternative implementation, the first driving device 700 is used to drive the transfer container 100 to rotate horizontally between the first transfer position 101 and the second transfer position 102, that is, the first driving device 700 can be a turntable device.
[0120] In a second embodiment of the transfer container 100, there is only one transfer container 100. The transfer container 100 is a fixed, non-movable container, and it has an inner cavity 150, a sample discharge port 160, and a sample suction port 170. The sample discharge port 160 and the sample suction port 170 are spaced apart at the top of the transfer container 100 and communicate with the inner cavity 150 respectively. The first sample dispensing device 200 dispenses all or part of the collected sample into the transfer container 100, including: the first sample dispensing device 200 dispenses all or part of the collected sample into the transfer container 100 through the sample discharge port 160. The second sample dispensing device 300 draws at least a portion of the sample dispensed by the first sample dispensing device 200 into the transfer container 100 from the transfer container 100, including: the second sample dispensing device 300 draws at least a portion of the sample dispensed by the first sample dispensing device 200 into the transfer container 100 through the sample suction port 170. In this embodiment, the transfer container 100 is designed to be fixed. By optimizing the structure of the transfer container 100, the first sample allocation device 200 and the second sample allocation device 300 interact with different ports of the transfer container 100, thereby also meeting the design requirement that the first transfer path 201 and the second transfer path 202 will not overlap or cross.
[0121] As a further embodiment of the second embodiment of the above-mentioned transfer container 100, the inner cavity 150 includes a first sub-cavity 151, a second sub-cavity 152 and a third sub-cavity 153. The first sub-cavity 151 extends vertically downward from the sample suction port 170 and the second sub-cavity 152 extends vertically downward from the sample discharge port 160.
[0122] In one implementation, the first sub-cavity 151 extends vertically downward from the sample suction port 170 to a greater depth than the second sub-cavity 152 extends vertically downward from the sample discharge port 160, and the third sub-cavity 153 extends obliquely from the bottom end of the second sub-cavity 152 to the first sub-cavity 151. In this design, the transfer container 100 is Y-shaped.
[0123] Alternatively, as another implementation, the first sub-cavity 151 extends vertically downward from the sampling port 170 to a depth equal to the second sub-cavity 152 extends vertically downward from the discharge port 160, and the third sub-cavity 153 extends horizontally from the bottom end of the second sub-cavity 152 to the bottom end of the first sub-cavity 151. In this scheme, the transfer container 100 is U-shaped.
[0124] As a third embodiment of the transfer container 100, there are multiple transfer containers 100, including a first transfer container 110 and a second transfer container 120, which are independently arranged. The first sample distribution device 200 distributes all or part of the collected samples into the transfer container 100, including: the first sample distribution device 200 distributing all or part of the collected samples into the first transfer container 110. The sample analyzer 10 also includes a transfer liquid path 901, which is connected between the first transfer container 110 and the second transfer container 120. The transfer liquid path 901 is used to transport all or part of the sample, at least partially distributed to the first transfer container 110 by the first sample distribution device 200, to the second transfer container 120. The second sample dispensing device 300 draws at least a portion of the sample that was dispensed to the transfer container 100 by the first sample dispensing device 200 from the transfer container 100, including: the second sample dispensing device 300 drawing at least a portion of the sample that was dispensed to the transfer container 100 by the first sample dispensing device 200 from the second transfer container 120. In this embodiment, both the first transfer container 110 and the second transfer container 120 are stationary, and the samples are transferred between the first transfer container 110 and the second transfer container 120 via pipeline transport. Since the first sample distribution device 200 and the second sample distribution device 300 do not directly transport samples through pipelines, but rather the first sample distribution device 200 first discharges the sample into the first transfer container 110, and then transports the sample from the first transfer container 110 to the second transfer container 120 through pipelines, and the second sample distribution device 300 then draws the sample from the second transfer container 120, this scheme can also eliminate the influence of air bubbles generated in the pipeline on the sample detection results, and can also achieve the design purpose of ensuring that the first transfer path 201 of the first sample distribution device 200 and the second transfer path 202 of the second sample distribution device 300 do not intersect or overlap.
[0125] As a fourth embodiment of the transfer container 100, there are multiple transfer containers 100, including a third transfer container 130 and a fourth transfer container 140, which are independently arranged. The sample analyzer 10 also includes a first driving device 700 and a second driving device 900. The first driving device 700 is used to drive the third transfer container 130 to move between the first transfer position 101 and the second transfer position 102, and the second driving device 900 is used to drive the fourth transfer container 140 to move between the third transfer position 106 and the fourth transfer position 107. The first sample distribution device 200 is used to distribute all or part of the collected samples into the transfer containers 100, including: distributing all or part of the collected first samples into the third transfer container 130 located at the first transfer position 101, and distributing all or part of the collected second samples into the fourth transfer container 140 located at the third transfer position 106. The aforementioned second sample dispensing device 300 is used to aspirate at least a portion of the sample dispensed by the first sample dispensing device 200 from the transfer container 100, including: aspirating at least a portion of the first sample dispensing device 200 from the third transfer container 130 located at the second transfer position 102, and aspirating at least a portion of the second sample dispensing device 200 from the fourth transfer container 140 located at the fourth transfer position 107. The first and second samples are two different types of bodily fluid samples. This embodiment allows for the use of different transfer containers 100 for different types of samples, which helps avoid the influence of difficult-to-clean samples or reagents on the test results of other types of sample testing items.
[0126] As a further embodiment of the fourth implementation of the aforementioned transfer container 100, the first driving device 700 and the second driving device 900 are independently arranged. The first driving device 700 is used to drive the third transfer container 130 to move horizontally and linearly back and forth between the first transfer position 101 and the second transfer position 102, and the second driving device 900 is used to drive the fourth transfer container 140 to move horizontally and linearly back and forth between the third transfer position 106 and the fourth transfer position 107; or, the first driving device 700 and the second driving device 900 are independently arranged, and the first driving device 700 is used to drive the third transfer container 130 to move horizontally and linearly back and forth between the first transfer position 101 and the second transfer position 102. The first transfer container 101 and the second transfer container 102 move back and forth along a curve, and the second driving device 900 drives the fourth transfer container 140 to move back and forth along a curve between the third transfer container 106 and the fourth transfer container 107; or, the first driving device 700 and the second driving device 900 are the same driving device, and the same driving device drives the third transfer container 130 and the fourth transfer container 140 to rotate, so that the third transfer container 130 rotates horizontally between the first transfer container 101 and the second transfer container 102, and the fourth transfer container 140 rotates horizontally between the third transfer container 106 and the fourth transfer container 107.
[0127] As a further embodiment of the fourth implementation of the aforementioned transfer container 100, the sample analyzer 10 further includes a reagent dispensing device for dispensing reagents. The controller is configured to: upon receiving a detection command for the first sample, control the first sample dispensing device 200 to collect at least a portion of the first sample from the first sample container 20 containing the first sample; control the first sample dispensing device 200 to move the collected first sample along the first transfer path 201 to the third transfer container 130 located at the first transfer position 101; control the first sample dispensing device 200 to allocate all or part of the collected first sample to the third transfer container 130 located at the first transfer position 101; and control the first driving device 700 to drive the third transfer container 130 containing the first sample from the first transfer position 101. 101 moves to the second transfer position 102, and controls the second sample dispensing device 300 to draw at least a portion of the first sample dispensed by the first sample dispensing device 200 into the third transfer container 130 located at the second transfer position 102. The second sample dispensing device 300 then moves the drawn-up first sample along the second transfer path 202 to the sample application position. The second sample dispensing device 300 then applies all or part of the drawn-up first sample to the first detection carrier located at the sample application position. The detection device then performs detection on the first sample dispensed by the second sample dispensing device 300 into the first detection carrier. The first sample is a sample that does not require staining.
[0128] As a further embodiment of the fourth implementation of the aforementioned transfer container 100, the controller is further configured to: upon receiving a detection command for the second sample, control the reagent dispensing device to dispense staining reagent into the second sample container 20 containing the second sample; control the first sample dispensing device 200 to draw at least a portion of the first mixture formed by mixing the second sample and the staining reagent from the second sample container 20; control the first sample dispensing device 200 to move the drawn first mixture along the first transfer path 201 to the fourth transfer container 140 located at the third transfer position 106; control the first sample dispensing device 200 to dispense all or part of the drawn first mixture into the fourth transfer container 140 located at the third transfer position 106; and control... The second driving device 900 drives the fourth transfer container 140, which contains the first mixture, to move from the third transfer position 106 to the fourth transfer position 107. The second sample dispensing device 300 draws at least a portion of the first mixture dispensed by the first sample dispensing device 200 into the fourth transfer container 140 located at the fourth transfer position 107. The second sample dispensing device 300 moves the drawn first mixture along the second transfer path 202 to the sample application position. The second sample dispensing device 300 dispenses all or part of the drawn first mixture into the second detection carrier located at the sample application position. The detection device detects the first mixture dispensed by the second sample dispensing device 300 into the second detection carrier. The first sample container 20 and the second sample container 20 are two independent sample containers 20; the first detection carrier and the second detection carrier are two independent carriers. The second sample is the sample requiring staining. In this embodiment, the second sample is mixed with the staining reagent in the second sample container 20.
[0129] As a further embodiment of the fourth implementation of the aforementioned transfer container 100, the controller is further configured to: upon receiving a detection command for the second sample, control the first sample dispensing device 200 to collect at least a portion of the second sample from the second sample container 20 containing the second sample and dispense all or part of the collected second sample to the staining pool; control the reagent dispensing device to dispense staining reagents to the staining pool; control the first sample dispensing device 200 to draw at least a portion of the first mixture formed by mixing the second sample and the staining reagent from the staining pool; control the first sample dispensing device 200 to move the drawn first mixture along the first transfer path 201 to the fourth transfer container 140 located at the third transfer position 106; and control the first sample dispensing device 200 to dispense all or part of the drawn first mixture to the fourth transfer container 140 located at the third transfer position 106. In the fourth transfer container 140 of the third transfer station 106, the second driving device 900 drives the fourth transfer container 140, which contains the first mixture, to move from the third transfer station 106 to the fourth transfer station 107. The second sample dispensing device 300 draws at least a portion of the first mixture dispensed by the first sample dispensing device 200 into the fourth transfer container 140 located at the fourth transfer station 107. The second sample dispensing device 300 moves the drawn first mixture along the second transfer path 202 to the sample application station. The second sample dispensing device 300 dispenses all or part of the drawn first mixture into the second detection carrier located at the sample application station. The detection device detects the first mixture dispensed by the second sample dispensing device 300 into the second detection carrier. In this embodiment, the second sample and the staining reagent are mixed in a separate staining pool.
[0130] As a further embodiment of the fourth implementation of the aforementioned transfer container 100, the controller is further configured to: upon receiving a detection command for the second sample, control the first sample dispensing device 200 to collect at least a portion of the second sample from the second sample container 20 containing the second sample; control the first sample dispensing device 200 to move the collected second sample along the first transfer path 201 to the fourth transfer container 140 located at the third transfer position 106; control the first sample dispensing device 200 to allocate all or part of the collected second sample to the fourth transfer container 140 located at the third transfer position 106; control the reagent dispensing device to allocate staining reagent to the fourth transfer container 140 located at the third transfer position 106; and control the second driving device. A fourth transfer container 140, containing a first mixture formed by mixing the second sample and staining reagent, is moved from a third transfer position 106 to a fourth transfer position 107. A second sample dispensing device 300 is controlled to draw at least a portion of the first mixture formed by mixing the second sample and staining reagent from the fourth transfer container 140 located at the fourth transfer position 107. The second sample dispensing device 300 moves the drawn first mixture along a second transfer path 202 to a sample application position. The second sample dispensing device 300 distributes all or part of the drawn first mixture into a second detection carrier located at the sample application position. A detection device is controlled to detect the first mixture dispensed by the second sample dispensing device 300 into the second detection carrier. In this embodiment, the second sample and staining reagent are mixed in the fourth transfer container 140.
[0131] In one implementation, the first sample dispensing device 200 includes a first sample needle for drawing at least a portion of a sample from the sample container 20 and dispensing all or part of the drawn sample into the transfer container 100. A controller is configured to control the first sample dispensing device 200 to move to the transfer container 100 located at the first transfer position 101. Controlling the first sample dispensing device 200 to move to the transfer container 100 located at the first transfer position 101 includes: controlling the first sample needle to rise from the sampling position 103; controlling the first sample needle to move horizontally above the first transfer position 101; and controlling the first sample needle to descend and at least partially extend into the transfer container 100 located at the first transfer position 101.
[0132] In one embodiment, the first sample dispensing device 200 further includes a first moving drive component, which is tractively connected to the first sample needle to drive the first sample needle to move between the sampling position 103 and the first transfer position 101. The aforementioned control of the first sample needle rising from the sampling position 103, controlling the first sample needle to move horizontally above the first transfer position 101, and controlling the first sample needle to descend and at least partially extend into the transfer container 100 located at the first transfer position 101 includes: controlling the first moving drive component to drive the first sample needle to rise from the sampling position 103, controlling the first moving drive component to drive the first sample needle to move horizontally above the first transfer position 101, and controlling the first moving drive component to drive the first sample needle to descend and at least partially extend into the transfer container 100 located at the first transfer position 101.
[0133] In one implementation, the first sample dispensing device 200 further includes a sampling line connected to the first sample needle and a first suction / dispensing power component connected to the sampling line. The first suction / dispensing power component is used to drive the first sample needle to perform suction and dispensing actions. Specifically, the first suction / dispensing power component is used to drive the first sample needle to collect samples from the sample container 20 through the sampling line, and to dispense samples into the transfer container 100 through the sampling line.
[0134] In one implementation, the sample analyzer 10 also includes a physical detection device for detecting the physical properties of the sample. In this embodiment, the sample analyzer 10 integrates dry chemical detection, formed element detection, and physical property detection functions.
[0135] As one implementation method, the physical detection device is used to detect at least one of the following physical properties of a sample: conductivity, turbidity, color, specific gravity, osmotic pressure, and odor.
[0136] As one implementation method, the physical detection device is used to detect at least one of the following physical properties of a sample: conductivity, turbidity, and color.
[0137] In one implementation, a portion of the sampling pipeline is formed as a physical property detection section. A first suction and discharge power component drives a first sample needle to draw at least a portion of the sample from the sample container 20 and drives a portion of the sample drawn by the first sample needle to move to the physical property detection section. A physical detection device is used to perform physical property detection on the first sample located in the physical property detection section. In this embodiment, a portion of the sampling pipeline is used as the site for physical property detection, eliminating the need for an additional physical property detection carrier. During physical property detection, only a portion of the first sample collected by the first sample dispensing device 200 needs to be drawn into the physical property detection section via the first suction and discharge power component. This simple operation method improves the efficiency of physical property detection. Furthermore, by placing the sample dispensing for physical property detection in the first sample dispensing device 200, the sample volume drawn by the second sample dispensing device 300 can be reduced, and the operation time of the second sample dispensing device 300 can be shortened, thereby improving the working efficiency of the second sample dispensing device 300.
[0138] In one implementation, the sample analyzer 10 further includes a first cleaning device, which performs a cleaning action on the first sample dispensing device 200. After the first sample dispensing device 200 completes the collection of one sample, it needs to perform a cleaning action before performing the collection of the next sample, thereby helping to avoid cross-contamination between samples.
[0139] In one implementation, the sample analyzer 10 also forms a first cleaning position. The first cleaning device is used to perform a cleaning operation on the first sample dispensing device 200 located at the first cleaning position.
[0140] In one embodiment, the first cleaning device performs a cleaning operation on the first sample dispensing device 200, including: the first cleaning device performs a cleaning operation on the inner wall and outer wall of the first sample needle.
[0141] In one embodiment, the first cleaning device performs a cleaning operation on the first sample distribution device 200, and further includes: the first cleaning device performs a cleaning operation on the inner wall of at least a portion of the sampling pipeline.
[0142] In one implementation, the second sample dispensing device 300 includes a second sample needle for drawing at least a portion of a sample from the transfer container 100 and dispensing all or part of the drawn sample into a testing carrier. The controller is also configured to control the second sample dispensing device 300 to move to the transfer container 100 located at the second transfer position 102. Controlling the second sample dispensing device 300 to move to the transfer container 100 located at the second transfer position 102 includes: controlling the second sample needle to move horizontally from a second standby position to above the second transfer position 102, and controlling the second sample needle to descend and at least partially extend into the transfer container 100 located at the second transfer position 102.
[0143] In one embodiment, the second sample dispensing device 300 further includes a second movement driving component, which is tractively connected to the second sample needle to drive the second sample needle to move between the sample dispensing position and the second transfer position 102. The aforementioned control of the second sample needle to move horizontally from the second standby position to above the second transfer position 102, and control of the second sample needle to descend and at least partially extend into the transfer container 100 located at the second transfer position 102, includes: controlling the second movement driving component to drive the second sample needle to move horizontally from the second standby position to above the second transfer position 102, and controlling the second movement driving component to drive the second sample needle to descend and at least partially extend into the transfer container 100 located at the second transfer position 102.
[0144] In one embodiment, the second sample dispensing device 300 further includes a suction tubing connected to the second sample needle and a second suction / dispensing power component connected to the suction tubing. The second suction / dispensing power component is used to drive the second sample needle to perform suction and dispensing actions. Specifically, the second suction / dispensing power component is used to drive the second sample needle through the suction tubing to collect samples from the transfer container 100, and to dispense samples into the dry chemical detection carrier 30 and / or the formed element detection carrier 40 through the suction tubing.
[0145] In one implementation, the sample analyzer 10 also includes a second cleaning device, which performs a cleaning action on the second sample dispensing device 300. After the second sample dispensing device 300 completes the sample dispensing action, it needs to perform a cleaning action before performing the sample dispensing action for the next sample, thereby helping to avoid cross-contamination between samples.
[0146] In one embodiment, the second cleaning device performs a cleaning operation on the second sample dispensing device 300, including: the second cleaning device performs a cleaning operation on the inner wall and outer wall of the second sample needle.
[0147] In one embodiment, the second cleaning device performs a cleaning action on the second sample dispensing device 300, and further includes: a third cleaning device performing a cleaning action on the inner wall of at least a portion of the sample aspiration tube.
[0148] In one implementation, the first sample needle is a needle with puncture function, i.e., the first sample needle is a puncture needle. The second sample needle is a needle without puncture function, i.e., the second sample needle is a non-puncture needle.
[0149] In a first embodiment of the detection device and sample dispensing device, the detection device includes a dry chemistry detection device 400 and a formed element detection device 500. A second sample dispensing device 300 is used to dispense all or part of the aspirated sample onto the dry chemistry detection carrier 30 located at the first dispensing position 104 and / or onto the formed element detection carrier 40 located at the second dispensing position 105. The dry chemistry detection device 400 is used to perform dry chemistry detection on the sample dispensed onto the dry chemistry detection carrier 30 by the second sample dispensing device 300. The formed element detection device 500 is used to perform formed element detection on the sample dispensed onto the formed element detection carrier 40 by the second sample dispensing device 300. The second transfer path 202 includes a second horizontal movement path 2021, with the first dispensing position 104 and the second dispensing position 105 spaced apart along the second horizontal movement path 2021.
[0150] In one implementation, the dry chemistry detection carrier 30 is a test strip, and the dry chemistry detection device 400 includes a test strip storage component 410, a test strip scheduling component, a test strip transmission component 420, and a result acquisition component 430. The test strip storage component 410 is used to store test strips. The test strip scheduling component is used to schedule the test strips from the test strip storage component 410 to the test strip transmission component 420 along the first conveying direction X2. The test strip transmission component 420 is used to transmit the test strips to the first sample application position 104. The second sample dispensing device 300 is used to distribute all or part of the aspirated sample onto the test strip located at the first sample application position 104. The test strip transmission component 420 is also used to transmit the sampled test strips sequentially to the reaction position and the result acquisition position along the first conveying direction X2. The result acquisition component 430 is used to acquire the reaction result information of the sample on the test strip at the result acquisition position. The controller is also used to obtain the chemical analysis result of the sample based on the reaction result information fed back by the result acquisition component 430.
[0151] In one implementation, the dry chemistry detection carrier 30 includes a test strip with multiple color patches. A second sample needle is used to dispense portions of the aspirated sample one by one into each color patch of the test strip. This dispensing of the sample into the color patches of the test strip by the second sample needle can also be referred to as the spotting action of the second sample needle.
[0152] In one embodiment, the formed element detection carrier 40 is a detection box with a cavity for containing a sample. The formed element detection device 500 includes a carrier supply component 510, a carrier transfer component 520, and a formed element detection component 530. The carrier supply component 510 is used to supply the detection box. The carrier transfer component 520 is used to transfer the detection box from the carrier supply component 510 to the second sample application position 105 along the second transport direction X3. The second sample dispensing device 300 is used to dispense all or part of the aspirated sample onto the detection box located at the second sample application position 105. The carrier transfer component 520 is also used to transfer the sampled detection box to the detection position along the second transport direction X3. The formed element detection component 530 is used to detect the formed elements in the sample in the detection box located at the detection position. The controller outputs the analysis results of at least some of the formed elements in the sample based on the detection data obtained by the formed element detection component 530 detecting the formed elements in the sample.
[0153] In one implementation, the formed element detection carrier 40 includes a disposable detection cartridge with a cavity. A second sample needle is used to discharge a portion of the aspirated sample into the cavity of the detection cartridge. This discharge of the sample into the cavity by the second sample needle can also be referred to as the sample dispensing action of the second sample needle. The disposable detection cartridge is used only for the formed element detection of one sample, eliminating the need for cleaning and recycling, thereby improving detection efficiency. Of course, in specific applications, the formed element detection carrier 40 can also be a detection pool with a cavity, which can be cleaned and recycled.
[0154] In one implementation, the first conveying direction X2, the second conveying direction X3, and the sample injection direction X1 are substantially parallel.
[0155] In one implementation, the first conveying direction X2, the second conveying direction X3, and the sample injection direction X1 are all approximately perpendicular to the second horizontal movement path 2021.
[0156] In one implementation, the sample introduction device 600, the first sample application position 104, and the second sample application position 105 are arranged sequentially in the direction of the second horizontal moving path 2021.
[0157] In one implementation, the sample introduction device 600 includes a loading area 610, an unloading area 620, and a sample scheduling component. The sample scheduling component is used to transport the sample container 20 containing the sample from the loading area 610 towards the unloading area 620 along the injection direction X1. The test strip storage component 410, the carrier supply component 510, and the loading area 610 are arranged on the same side near the sample analyzer 10. This arrangement, with the loading of the dry chemical detection carrier 30, the formed element detection carrier 40, and the sample loading area 610 all located on the same side of the sample analyzer 10, facilitates operation by the operator.
[0158] In one embodiment, the dry chemical detection device 400 further includes a first recovery component 440, and the test strip transfer component 420 is further used to transfer the test strip after obtaining the reaction result information along the first transport direction X2 to the first recovery component 440. The formed element detection device 500 further includes a second recovery component 540, and the carrier transfer component 520 is further used to transfer the test box after the formed element detection is completed along the second transport direction X3 to the second recovery component 540. The first recovery component 440 and the test strip storage component 410 are respectively arranged close to opposite sides of the sample analyzer 10 along the first transport direction X2. The second recovery component 540 and the carrier supply component 510 are respectively arranged close to opposite sides of the sample analyzer 10 along the second transport direction X3. The first recovery component 440 and the second recovery component 540 may be the same recovery component or two independently arranged recovery components. In this embodiment, both the dry chemical detection carrier 30 and the formed element detection carrier 40 are disposable carriers and do not need to be cleaned and recycled within the sample analyzer 10.
[0159] In the above scheme, the sample loading actions required for dry chemistry detection and the sample loading actions required for formed element detection are performed by the same sample needle. Of course, in specific applications, as an alternative implementation scheme, the sample loading actions required for dry chemistry detection and the sample loading actions required for formed element detection can also be performed by different sample needles, and the specific schemes are described below.
[0160] As one implementation method for dry chemical detection and formed element detection, in which different sample needles perform sample dispensing actions, the detection device includes a dry chemical detection device 400 and a formed element detection device 500; a second sample dispensing device 300 is used to dispense all or part of the aspirated sample into the dry chemical detection carrier 30 located at the first sample dispensing position 104; the sample analyzer 10 also includes a third sample dispensing device 800, which is set independently of the first sample dispensing device 200 and the second sample dispensing device 300, and is used to aspirate at least a portion of the sample dispensed by the first sample dispensing device 200 into the transfer container 100 from the transfer container 100, and to drive the aspirated sample... The sample moves along the third transfer path 203 to the second sample dispensing position 105, and distributes all or part of the aspirated sample into the formed element detection carrier 40 located at the second sample dispensing position 105; the dry chemical detection device 400 is used to perform dry chemical detection on the sample dispensed by the second sample dispensing device 300 into the dry chemical detection carrier 30; the formed element detection device 500 is used to perform formed element detection on the sample dispensed by the third sample dispensing device 800 into the formed element detection carrier 40; the first transfer path 201, the second transfer path 202, and the third transfer path 203 are arranged alternately, or the first transfer path 201, the second transfer path 202, and the third transfer path 203 are arranged crosswise. The third sample dispensing device 800 includes a third sample needle. In this embodiment, the sample for dry chemical detection and the sample for formed element detection are dispensed by different sample needles.
[0161] In one implementation, the third transfer path 203 includes a third horizontal movement path 2031, which is arranged parallel to the second horizontal movement path 2021 at intervals, or the third horizontal movement path 2031 and the second horizontal movement path 2021 are arranged at intervals and non-parallel, for example, vertically.
[0162] In one implementation, the transfer container 100 is movable. A first driving device 700 is used to drive the transfer container 100 to move between the first transfer position 101, the second transfer position 102 and the fifth transfer position 108, and a third sample dispensing device 800 is used to draw samples from the transfer container 100 located at the fifth transfer position 108.
[0163] Alternatively, as another implementation, the transfer container 100 can also be fixed. The transfer container 100 has an inner cavity 150, a sample discharge port 160 and two sample suction ports 170. The second sample dispensing device 300 is used to draw samples from the transfer container 100 through one sample suction port 170, and the third sample dispensing device 800 is used to draw samples from the transfer container 100 through the other sample suction port 170.
[0164] In the above scheme, the sample is subjected to both dry chemical detection and formed element detection. Of course, in specific applications, there are also cases where the sample is only subjected to dry chemical detection or only formed element detection.
[0165] As one embodiment of the sample analyzer 10, which includes dry chemical detection function but does not include formed element detection function, the detection device includes a dry chemical detection device 400; a second sample dispensing device 300 is used to dispense all or part of the aspirated sample into the dry chemical detection carrier 30 located at the first sample dispensing position 104; the dry chemical detection device 400 is used to perform dry chemical detection on the sample dispensed into the dry chemical detection carrier 30 by the second sample dispensing device 300.
[0166] As one embodiment of the sample analyzer 10, which includes formed element detection function but not dry chemical detection function, the detection device includes a formed element detection device 500; a second sample dispensing device 300 for dispensing all or part of the aspirated sample into a formed element detection carrier 40 located at the second sample dispensing position 105; and a formed element detection device 500 for performing formed element detection on the sample dispensed into the formed element detection carrier 40 by the third sample dispensing device 800.
[0167] In one embodiment, the sample analyzer 10 further includes a first cleaning device and a second cleaning device. The first cleaning device is used to perform a cleaning action on a first sample dispensing device 200 located at a first cleaning position. The first sample dispensing device 200 is used to collect at least a portion of the sample from the sample container 20 located at the sampling position 103. The first cleaning position is located between the sampling position 103 and the transfer container 100 along a first transfer path 201. The second cleaning device is used to perform a cleaning action on a second sample dispensing device 300 located at a second cleaning position. The second cleaning position is located between the transfer container 100 and the sample application position along a second transfer path 202.
[0168] In one embodiment, the sample analyzer 10 further includes a first driving device 700 and a third cleaning device. The first driving device 700 is used to drive the transfer container 100 to move between a first transfer position 101 and a second transfer position 102. A first sample dispensing device 200 is used to dispense all or part of the collected sample into the transfer container 100 located at the first transfer position 101. A second sample dispensing device 300 is used to aspirate at least a portion of the sample dispensed by the first sample dispensing device 200 into the transfer container 100 from the transfer container 100 located at the second transfer position 102. The third cleaning device is used to perform a cleaning action on the transfer container 100. The third cleaning device performing a cleaning action on the transfer container 100 includes: the third cleaning device performing a cleaning action on the transfer container 100 located at the second transfer position 102, or on the transfer container 100 located at the first transfer position 101, or on the transfer container 100 during its movement from the second transfer position 102 towards the first transfer position 101.
[0169] As one implementation method, the parallel timing design scheme for simultaneous detection of dry chemistry, formed elements, and physical properties includes the following path for the sampling needle (first sample needle): insertion into sample container 20 → sample sampling → physical property detection → needle movement to transfer container 100 → sample discharge into transfer container 100 → needle movement to the first cleaning tank for cleaning; and the path for the dispensing needle (second sample needle): insertion into transfer container 100 → sample aspiration → needle movement to dry chemistry detection carrier 30 for sample dispensing → needle movement to formed element detection carrier 40 for sample dispensing → needle movement to the second cleaning tank for cleaning. The parallel timing of the two needles is achieved by adding the transfer container 100.
[0170] As one implementation method, the parallel timing design scheme for simultaneous detection of dry chemical and physical properties includes the following sampling needle path: needle insertion into sample container 20 → sample sampling → physical property detection → needle movement to transfer container 100 → sample discharge into transfer container 100 → needle movement to the first cleaning tank for cleaning; and the sample dispensing needle path: needle insertion into transfer container 100 → sample aspiration → needle movement to dry chemical detection carrier 30 for sample dispensing → needle movement to the second cleaning tank for cleaning. The addition of transfer container 100 enables parallel timing of the two needles.
[0171] As one implementation method, the parallel timing action design scheme for simultaneous detection of formed elements and physical properties includes the following steps: Sampling needle path: needle inserted into sample container 20 → sample sampling → physical property detection → needle moves to transfer container 100 → sample discharge to transfer container 100 → needle moves to the first cleaning tank for cleaning; Sample dispensing needle path: needle inserted into transfer container 100 → sample aspiration → needle moves to formed element detection carrier 40 for sample dispensing → needle moves to the second cleaning tank for cleaning. The addition of transfer container 100 enables parallel timing actions of the two needles.
[0172] In one implementation, the sample analyzer 10 is a urine analyzer. The urine analyzer can perform routine urine tests on urine samples. Routine urine analysis has significant diagnostic value in clinical testing. Routine urine tests in clinical testing include physical property testing, dry chemical testing, and formed element testing. Physical property testing is performed by independent functional units such as conductivity and physical modules. Dry chemical testing involves the sample being dropped sequentially onto multiple color patches on a test strip using a sampling needle (the aforementioned second sample needle), and the color change of the color patches is detected. Formed element testing involves the sample being added to a test cartridge using the second sample needle, and images are captured using a microscopic imaging device. The formed elements are then detected through image classification and recognition. Of course, in specific applications, the sample analyzer 10 is not limited to a urine analyzer. For example, the sample analyzer 10 can also be a gynecological microecological analyzer, a semen analyzer, a urine and gynecological microecological integrated machine, a urine and semen integrated machine, a semen and gynecological microecological integrated machine, or a urine, gynecological microecological, and semen integrated machine.
[0173] This embodiment proposes a layout scheme for the sample analyzer 10, which, while satisfying the requirements for detection results and detection speed, allows the sample analyzer 10 to be miniaturized as much as possible, thus saving space in the department. Specifically, this embodiment decouples the transfer paths of the first and second sample needles, ensuring that they do not intersect or overlap, allowing for more efficient use of internal space for layout, thereby achieving a miniaturized design in the length direction (sample injection direction X1) of the sample analyzer 10. In addition, the transport paths of the dry chemical detection carrier 30 and the formed element detection carrier 40 are arranged in parallel, one in front of the other, which facilitates a miniaturized design in the depth direction (parallel to the direction of the second horizontal movement path 2021) of the sample analyzer 10.
[0174] A second aspect of the present invention provides a sample analyzer 10, the sample analyzer 10 comprising:
[0175] 100 transit containers;
[0176] The first sample distribution device 200 is used to collect at least a portion of the samples from the sample container 20 located at the sampling position 103 and distribute all or part of the collected samples to the transfer container 100.
[0177] The second sample dispensing device 300 is set independently of the first sample dispensing device 200. The second sample dispensing device 300 is used to aspirate at least part of the sample dispensed to the transfer container 100 by the first sample dispensing device 200 from the transfer container 100, and to move the aspirated sample along the second transfer path 202 to the first sample dispensing position 104 and / or the second sample dispensing position 105, and to dispense all or part of the aspirated sample into the dry chemical detection carrier 30 located at the first sample dispensing position 104 and / or the formed element detection carrier 40 located at the second sample dispensing position 105.
[0178] Dry chemical detection device 400 is used to perform dry chemical detection on a sample dispensed by the second sample dispensing device 300 into the dry chemical detection carrier 30.
[0179] Formed element detection device 500 is used to perform formed element detection on a sample dispensed by the second sample dispensing device 300 into the formed element detection carrier 40.
[0180] The controller is used to control the operation of at least the first sample dispensing device 200, the second sample dispensing device 300, the dry chemical detection device 400, and the formed element detection device 500.
[0181] The sampling position 103 and the second transfer path 202 are set at intervals.
[0182] The sample analyzer 10 provided in the second aspect of the present invention focuses on a scheme in which a first sample dispensing device 200, a second sample dispensing device 300, and a transfer container 100 cooperate to complete the sample dispensing operation of a dry chemical detection device 400 and a formed element detection device 500. The first sample dispensing device 200 is used to sample and dispense from the sample container 20 to the transfer container 100, and the second sample dispensing device 300 is used to draw samples from the transfer container 100 and dispense them to the dry chemical detection carrier 30 and / or the formed element detection carrier 40.
[0183] In one embodiment, the first sample dispensing device 200 includes a first sample needle, a sampling tubing connected to the first sample needle, and a first suction and discharge power component connected to the sampling tubing. The first suction and discharge power component is used to drive the first sample needle to collect at least a portion of the sample from the sample container 20 located at the sampling position 103, and to drive the first sample needle to dispense all or part of the collected sample into the transfer container 100. The second sample dispensing device 300 includes a second sample needle, a suction tubing connected to the second sample needle, and a second suction and discharge power component connected to the suction tubing. The second suction and discharge power component is used to drive the second sample needle to aspirate at least a portion of the sample dispensed to the transfer container 100 by the first sample dispensing device 200 from the transfer container 100, and to drive the second sample needle to dispense all or part of the aspirated sample into the dry chemical detection carrier 30 and / or the formed element detection carrier 40. In this embodiment, the first sample dispensing device 200 discharges the sample into the transfer container 100 by needle delivery, and the second sample dispensing device 300 also draws the sample from the sample container 20 by needle delivery, which helps to avoid the risk of air bubbles in the sample dispensed by the second sample dispensing device 300.
[0184] Alternatively, as another implementation, the first sample dispensing device 200 includes a first sample needle, a sampling tubing connected to the first sample needle, and a first suction-dispensing power component connected to the sampling tubing. The sampling tubing is also connected to a transfer container 100. The first suction-dispensing power component is used to drive the first sample needle to collect at least a portion of the sample from the sample container 20 located at the sampling position 103, and to drive the sampling tubing to dispense all or part of the sample collected by the first sample needle into the transfer container 100. The second sample dispensing device 300 includes a second sample needle, a suction tubing connected to the second sample needle, and a second suction-dispensing power component connected to the suction tubing. The second suction-dispensing power component is used to drive the second sample needle to draw at least a portion of the sample dispensed to the transfer container 100 by the first sample dispensing device 200 from the transfer container 100, and to drive the second sample needle to dispense all or part of the drawn sample into the dry chemical detection carrier 30 and / or the formed element detection carrier 40. In this embodiment, the first sample dispensing device 200 discharges the sample into the transfer container 100 via pipeline transportation, and the second sample dispensing device 300 draws the sample from the sample container 20 via needle transportation, which also helps to avoid the risk of air bubbles in the sample dispensed by the second sample dispensing device 300.
[0185] Apart from the above, other parts of the sample analyzer 10 provided in the second aspect of the present invention can be referred to the sample analyzer 10 provided in the first aspect, and will not be described in detail here.
[0186] A third aspect of the present invention provides a sample analyzer 10, the sample analyzer 10 comprising:
[0187] 100 transit containers;
[0188] The first driving device 700 is used to drive the transfer container 100 to move between the first transfer position 101 and the second transfer position 102.
[0189] The first sample distribution device 200 is used to collect at least a portion of the samples from the sample container 20 and distribute all or part of the collected samples to the transfer container 100 located at the first transfer station 101.
[0190] The second sample dispensing device 300 is set independently of the first sample dispensing device 200, and the second sample dispensing device 300 is used to aspirate at least part of the sample dispensed to the transfer container 100 by the first sample dispensing device 200 from the transfer container 100 located at the second transfer position 102, and to dispense all or part of the aspirated sample to the detection carrier located at the sample application position.
[0191] The detection device is used to detect samples dispensed into the detection carrier by the second sample dispensing device 300;
[0192] The controller is used to control the operation of the first driving device 700, the first sample dispensing device 200, the second sample dispensing device 300, and the detection device.
[0193] The sample analyzer 10 provided in the third aspect of the present invention focuses on defining a scheme in which a first sample dispensing device 200, a second sample dispensing device 300 and a moving transfer container 100 cooperate to complete a sample dispensing action. The first sample dispensing device 200 is used to sample from the sample container 20 and dispense it to a transfer container 100 at a station (first transfer station 101). The transfer container 100 moves the sample to another station (second transfer station 102). The second sample dispensing device 300 is used to extract the sample from the transfer container 100 located at the other station (second transfer station 102) and dispense it to the detection carrier.
[0194] Apart from the above, other parts of the sample analyzer 10 provided in the third aspect of the present invention can be referred to the sample analyzer 10 provided in the first and second aspects above, and will not be described in detail here.
[0195] The above description is merely a preferred embodiment of the present invention and does not limit the patent scope of the present invention. Any equivalent structural transformations made using the contents of the present invention's specification and drawings under the inventive concept of the present invention, or direct / indirect applications in other related technical fields, are included within the patent protection scope of the present invention.
Claims
1. A sample analyzer, characterized in that: include: Transit container; A first sample distribution device is configured to collect at least a portion of the samples from a sample container, move the collected samples along a first transfer path to the transfer container, and distribute all or part of the collected samples into the transfer container. The second sample dispensing device is set independently of the first sample dispensing device, and the second sample dispensing device is used to draw at least a portion of the sample that was dispensed to the transfer container by the first sample dispensing device from the transfer container, and to move the drawn sample along the second transfer path to the sample dispensing position, and to dispense all or part of the drawn sample into the detection carrier located at the sample dispensing position; A detection device for detecting a sample dispensed into the detection carrier by the second sample dispensing device; A controller, wherein the controller is at least used to control the operation of the first sample dispensing device, the second sample dispensing device, and the detection device; The first transfer path and the second transfer path are set at intervals.
2. The sample analyzer as described in claim 1, characterized in that: The sample analyzer also includes a sample introduction device, which is used to drive the sample container containing the sample to be transported to the sampling position along the sample introduction direction; In the injection direction, the first transfer path and the second transfer path are spaced apart.
3. The sample analyzer as described in claim 2, characterized in that: In the injection direction, the second transfer path and the first transfer path are arranged sequentially.
4. The sample analyzer as described in claim 2 or 3, characterized in that: The first transfer path includes a first horizontal movement path, and the second transfer path includes a second horizontal movement path; The first horizontal movement path and the second horizontal movement path are spaced apart and parallel, and / or both the first horizontal movement path and the second horizontal movement path are perpendicular to the injection direction.
5. The sample analyzer as described in claim 2 or 3, characterized in that: The first transfer path includes a first horizontal movement path, and the second transfer path includes a second horizontal movement path; The first horizontal movement path and the second horizontal movement path are spaced apart and not parallel; and / or, the first horizontal movement path is set at an angle greater than 0° and less than 90° relative to the injection direction, and the second horizontal movement path is perpendicular to the injection direction.
6. The sample analyzer as described in claim 1, characterized in that: The number of the transfer container is one, and the sample analyzer further includes a first driving device, which is used to drive the transfer container to move between the first transfer position and the second transfer position; The first sample allocation device allocates all or part of the collected samples to the transfer container, including: the first sample allocation device allocates all or part of the collected samples to the transfer container located at the first transfer position; The second sample dispensing device draws at least a portion of the sample that was dispensed to the transfer container by the first sample dispensing device from the transfer container, including: the second sample dispensing device draws at least a portion of the sample that was dispensed to the transfer container by the first sample dispensing device from the transfer container located at the second transfer position.
7. The sample analyzer as described in claim 6, characterized in that: The first driving device is used to drive the transfer container to move horizontally in a straight line or curve between the first transfer position and the second transfer position; Alternatively, the first driving device is used to drive the transfer container to rotate horizontally between the first transfer position and the second transfer position.
8. The sample analyzer as described in claim 1, characterized in that: The number of transfer containers is one. The transfer container is a fixed and non-movable container. The transfer container has an inner cavity, a discharge port and a suction port. The discharge port and the suction port are spaced apart on the top of the transfer container and are respectively connected to the inner cavity. The first sample distribution device distributes all or part of the collected samples into the transfer container, including: the first sample distribution device distributes all or part of the collected samples into the transfer container through the discharge port; The second sample dispensing device aspirates at least a portion of the sample that was dispensed into the transfer container by the first sample dispensing device from the transfer container, including: the second sample dispensing device aspirates at least a portion of the sample that was dispensed into the transfer container by the first sample dispensing device from the transfer container through the sampling port.
9. The sample analyzer as described in claim 8, characterized in that: The inner cavity includes a first sub-cavity, a second sub-cavity, and a third sub-cavity. The first sub-cavity extends vertically downward from the sample suction port, and the second sub-cavity extends vertically downward from the sample discharge port. The first sub-cavity extends vertically downward from the sampling port to a greater depth than the second sub-cavity extends vertically downward from the discharge port, and the third sub-cavity extends obliquely from the bottom of the second sub-cavity to the first sub-cavity; or, the first sub-cavity extends vertically downward from the sampling port to a depth equal to the second sub-cavity extends vertically downward from the discharge port, and the third sub-cavity extends horizontally from the bottom of the second sub-cavity to the bottom of the first sub-cavity.
10. The sample analyzer as described in claim 1, characterized in that: The number of transit containers is multiple, including a first transit container and a second transit container, and the first transit container and the second transit container are set up independently of each other; The first sample allocation device allocates all or part of the collected samples to the transfer container, including: the first sample allocation device allocates all or part of the collected samples to the first transfer container; The sample analyzer further includes a transfer fluid path, which is connected between the first transfer container and the second transfer container. The transfer fluid path is used to transport all or part of the sample, which is at least partially dispensed to the first transfer container by the first sample dispensing device, to the second transfer container. The second sample dispensing device draws at least a portion of the sample that was dispensed to the transfer container by the first sample dispensing device from the transfer container, including: the second sample dispensing device draws at least a portion of the sample that was dispensed to the transfer container by the first sample dispensing device from the second transfer container.
11. The sample analyzer as described in claim 1, characterized in that: The number of transit containers is multiple, including a third transit container and a fourth transit container, and the third transit container and the fourth transit container are set up independently of each other; The sample analyzer further includes a first driving device and a second driving device. The first driving device is used to drive the third transfer container to move between the first transfer position and the second transfer position, and the second driving device is used to drive the fourth transfer container to move between the third transfer position and the fourth transfer position. The first sample allocation device is used to allocate all or part of the collected samples to the transfer container, including: the first sample allocation device is used to allocate all or part of the collected first samples to the third transfer container located at the first transfer position, and to allocate all or part of the collected second samples to the fourth transfer container located at the third transfer position; The second sample dispensing device is used to draw at least a portion of the sample that was dispensed to the transfer container by the first sample dispensing device from the transfer container, including: the second sample dispensing device is used to draw at least a portion of the first sample that was dispensed to the third transfer container by the first sample dispensing device from the third transfer container located at the second transfer position, and is used to draw at least a portion of the second sample that was dispensed to the fourth transfer container by the first sample dispensing device from the fourth transfer container located at the fourth transfer position; The first sample and the second sample are two different types of body fluid samples.
12. The sample analyzer as described in claim 11, characterized in that: The first driving device and the second driving device are independently configured. The first driving device is used to drive the third transfer container to move horizontally and linearly back and forth between the first transfer position and the second transfer position. The second driving device is used to drive the fourth transfer container to move horizontally and linearly back and forth between the third transfer position and the fourth transfer position. Alternatively, the first driving device and the second driving device are set independently of each other. The first driving device is used to drive the third transfer container to move back and forth in a curve between the first transfer position and the second transfer position, and the second driving device is used to drive the fourth transfer container to move back and forth in a curve between the third transfer position and the fourth transfer position. Alternatively, the first driving device and the second driving device are the same driving device, which is used to drive the third transfer container and the fourth transfer container to rotate, so that the third transfer container rotates horizontally between the first transfer position and the second transfer position, and so that the fourth transfer container rotates horizontally between the third transfer position and the fourth transfer position.
13. The sample analyzer as described in claim 11, characterized in that: The sample analyzer also includes a reagent dispensing device; The controller is configured to: upon receiving a detection instruction for the first sample, control the first sample dispensing device to collect at least a portion of the first sample from a first sample container containing the first sample; control the first sample dispensing device to move the collected first sample along the first transfer path to the third transfer container located at the first transfer position; control the first sample dispensing device to allocate all or part of the collected first sample to the third transfer container located at the first transfer position; control the first driving device to drive the third transfer container containing the first sample from the first transfer position to the second transfer position; control the second sample dispensing device to extract at least a portion of the first sample allocated to the third transfer container by the first sample dispensing device from the third transfer container located at the second transfer position; control the second sample dispensing device to move the extracted first sample along the second transfer path to the sample loading position; control the second sample dispensing device to allocate all or part of the extracted first sample to a first detection carrier located at the sample loading position; and control the detection device to detect the first sample allocated to the first detection carrier by the second sample dispensing device. The controller is also configured to: Upon receiving a detection command for the second sample, the reagent dispensing device is controlled to dispense staining reagent into a second sample container containing the second sample. The first sample dispensing device is controlled to draw at least a portion of a first mixture formed by mixing the second sample and the staining reagent from the second sample container. The first sample dispensing device is controlled to move the drawn first mixture along the first transfer path to a fourth transfer container located at the third transfer position. The first sample dispensing device then dispenses all or part of the drawn first mixture into the fourth transfer container located at the third transfer position. The second driving device is controlled to drive the container containing the first mixture... The fourth transfer container of the mixture moves from the third transfer position to the fourth transfer position, controls the second sample dispensing device to draw at least a portion of the first mixture that was dispensed to the fourth transfer container by the first sample dispensing device from the fourth transfer container located at the fourth transfer position, controls the second sample dispensing device to move the drawn first mixture along the second transfer path to the sample dispensing position, controls the second sample dispensing device to dispense all or part of the drawn first mixture into the second detection carrier located at the sample dispensing position, and controls the detection device to detect the first mixture dispensed by the second sample dispensing device into the second detection carrier; Alternatively, upon receiving a detection command for the second sample, the system controls the first sample dispensing device to collect at least a portion of the second sample from the second sample container containing the second sample and to dispense all or part of the collected second sample into the staining pool; controls the reagent dispensing device to dispense staining reagent into the staining pool; controls the first sample dispensing device to draw at least a portion of the first mixture formed by mixing the second sample and the staining reagent from the staining pool; controls the first sample dispensing device to move the drawn first mixture along the first transfer path to the fourth transfer container located at the third transfer position; and controls the first sample dispensing device to dispense all or part of the drawn first mixture into the fourth transfer container located at the third transfer position. In the four transfer containers, the second driving device is controlled to drive the fourth transfer container containing the first mixture to move from the third transfer position to the fourth transfer position; the second sample dispensing device is controlled to draw at least a portion of the first mixture dispensed by the first sample dispensing device to the fourth transfer container located at the fourth transfer position; the second sample dispensing device is controlled to move the drawn first mixture along the second transfer path to the sample dispensing position; the second sample dispensing device is controlled to dispense all or part of the drawn first mixture into the second detection carrier located at the sample dispensing position; and the detection device is controlled to detect the first mixture dispensed by the second sample dispensing device into the second detection carrier. Alternatively, upon receiving a detection command for the second sample, the first sample dispensing device is controlled to collect at least a portion of the second sample from a second sample container containing the second sample; the first sample dispensing device is controlled to move the collected second sample along the first transfer path to the fourth transfer container located at the third transfer position; the first sample dispensing device distributes all or part of the collected second sample into the fourth transfer container located at the third transfer position; the reagent dispensing device distributes staining reagent into the fourth transfer container located at the third transfer position; and the second driving device is controlled to drive a container loaded with a mixture of the second sample and the staining reagent. The fourth transfer container of the first mixture is moved from the third transfer position to the fourth transfer position. The second sample dispensing device is controlled to draw at least a portion of the first mixture formed by mixing the second sample and the staining reagent from the fourth transfer container located at the fourth transfer position. The second sample dispensing device is controlled to move the drawn first mixture along the second transfer path to the sample dispensing position. The second sample dispensing device is controlled to dispense all or part of the drawn first mixture into the second detection carrier located at the sample dispensing position. The detection device is controlled to detect the first mixture dispensed by the second sample dispensing device into the second detection carrier. The first sample container and the second sample container are two independent sample containers; The first detection vehicle and the second detection vehicle are two independent vehicles.
14. The sample analyzer as described in claim 1, characterized in that: The first sample dispensing device includes a first sample needle, which is a needle with puncture function; the second sample dispensing device includes a second sample needle, which is a needle without puncture function. And / or, the sample analyzer further includes a physical detection device, wherein the first sample dispensing device includes a first sample needle, a sampling tube connected to the first sample needle, and a first suction and discharge power component connected to the sampling tube, wherein a portion of the sampling tube forms a physical property detection tube section; the first suction and discharge power component is used to drive the first sample needle to draw at least a portion of the sample from the sample container and to drive a portion of the sample drawn by the first sample needle to move to the physical property detection tube section, and the physical detection device is used to perform physical property detection on the first sample located in the physical property detection tube section.
15. The sample analyzer according to any one of claims 1 to 14, characterized in that: The detection devices include dry chemical detection devices and formed element detection devices; The second sample dispensing device is used to dispense all or part of the aspirated sample onto the dry chemical detection carrier located at the first sample dispensing position and / or onto the formed element detection carrier located at the second sample dispensing position; The dry chemistry detection device is used to perform dry chemistry detection on the sample dispensed by the second sample dispensing device onto the dry chemistry detection carrier; The formed element detection device is used to perform formed element detection on the sample that is dispensed to the formed element detection carrier by the second sample dispensing device; The second transfer path includes a second horizontal movement path, and the first and second sample application positions are distributed at intervals along the second horizontal movement path.
16. The sample analyzer as described in claim 15, characterized in that: The dry chemical detection carrier is a test strip. The dry chemical detection device includes a test strip storage component, a test strip scheduling component, a test strip transmission component, and a result acquisition component. The test strip storage component stores the test strips. The test strip scheduling component schedules the test strips from the test strip storage component to the test strip transmission component along a first conveying direction. The test strip transmission component transmits the test strips to a first sample application position. A second sample dispensing device distributes all or part of the aspirated sample onto the test strip located at the first sample application position. The test strip transmission component also transmits the sampled test strips sequentially along the first conveying direction to a reaction position and a result acquisition position. The result acquisition component acquires the reaction result information of the sample on the test strip at the result acquisition position. The controller also obtains the chemical analysis result of the sample based on the reaction result information fed back by the result acquisition component. The formed element detection carrier is a detection box with a cavity for containing the sample. The formed element detection device includes a carrier supply component, a carrier transmission component, and a formed element detection component. The carrier supply component supplies the detection box. The carrier transmission component transports the detection box from the carrier supply component to a second sample dispensing position along a second conveying direction. The second sample dispensing device dispenses all or part of the aspirated sample onto the detection box located at the second sample dispensing position. The carrier transmission component also transports the sampled detection box to the detection position along the second conveying direction. The formed element detection component performs formed element detection on the sample in the detection box located at the detection position. The controller outputs the analysis results of at least some of the formed elements in the sample based on the detection data obtained by the formed element detection component performing formed element detection on the sample. The sample analyzer also includes a sample introduction device, which is used to drive the sample container containing the sample to be transported to the sampling position along the sample introduction direction; The first conveying direction, the second conveying direction, and the sample injection direction are approximately parallel.
17. The sample analyzer as described in claim 16, characterized in that: The first conveying direction, the second conveying direction, and the sample injection direction are all approximately perpendicular to the second horizontal movement path; And / or, in the direction of the second horizontal moving path, the sample introduction device, the first sample application position, and the second sample application position are arranged sequentially.
18. The sample analyzer as described in claim 16, characterized in that: The sample introduction device includes a loading area, an unloading area, and a sample scheduling component. The sample scheduling component is used to transport a sample container loaded with the sample from the loading area toward the unloading area along the sample introduction direction. The test strip storage component, the carrier supply component, and the loading area are located on the same side near the sample analyzer.
19. The sample analyzer as described in claim 18, characterized in that: The dry chemical detection device further includes a first recovery component, and the test strip transmission component is also used to transmit the test strip after obtaining the reaction result information to the first recovery component along the first conveying direction. The formed element detection device further includes a second recycling component, and the carrier conveying component is also used to convey the detection box after the formed element detection is completed to the second recycling component along the second conveying direction; The first recycling component and the test strip storage component are respectively arranged close to opposite sides of the sample analyzer along the first conveying direction; The second recovery component and the carrier supply component are respectively arranged close to opposite sides of the sample analyzer along the second conveying direction; The first recycling component and the second recycling component are either the same recycling component or two independently configured recycling components.
20. The sample analyzer according to any one of claims 1 to 14, characterized in that: The detection device includes a dry chemistry detection device and a formed element detection device; the second sample dispensing device is used to dispense all or part of the aspirated sample into the dry chemistry detection carrier located at the first sample dispensing position; the sample analyzer further includes a third sample dispensing device, which is set independently of the first sample dispensing device and the second sample dispensing device, and the third sample dispensing device is used to aspirate at least part of the sample dispensed by the first sample dispensing device into the transfer container from the transfer container, and to move the aspirated sample along a third transfer path to the second sample dispensing position, and to dispense all or part of the aspirated sample into the formed element detection carrier located at the second sample dispensing position; The dry chemical detection device is used to perform dry chemical detection on the sample dispensed by the second sample dispensing device into the dry chemical detection carrier; the formed element detection device is used to perform formed element detection on the sample dispensed by the third sample dispensing device into the formed element detection carrier; the first transfer path, the second transfer path, and the third transfer path are arranged at intervals, or the first transfer path, the second transfer path, and the third transfer path are arranged at intersections; Alternatively, the detection device includes a dry chemistry detection device; the second sample dispensing device is used to dispense all or part of the aspirated sample into a dry chemistry detection carrier located at a first sample dispensing position; the dry chemistry detection device is used to perform dry chemistry detection on the sample dispensed into the dry chemistry detection carrier by the second sample dispensing device; Alternatively, the detection device includes a formed element detection device; the second sample dispensing device is used to dispense all or part of the aspirated sample into a formed element detection carrier located at the second sample dispensing position; The formed element detection device is used to perform formed element detection on the sample allocated to the formed element detection carrier by the third sample allocation device.
21. The sample analyzer according to any one of claims 1 to 14, characterized in that: The sample analyzer further includes a first cleaning device and a second cleaning device. The first cleaning device is used to perform a cleaning action on the first sample dispensing device located at a first cleaning position. The first sample dispensing device is used to collect at least a portion of the sample from the sample container located at the sampling position. The first cleaning position is located between the sampling position and the transfer container along the first transfer path. The second cleaning device is used to perform a cleaning action on the second sample dispensing device located at a second cleaning position. The second cleaning position is located between the transfer container and the sample application position along the second transfer path. And / or, the sample analyzer further includes a first driving device and a third cleaning device, wherein the first driving device is used to drive the transfer container to move between a first transfer position and a second transfer position; the first sample dispensing device is used to dispense all or part of the collected sample into the transfer container located at the first transfer position; the second sample dispensing device is used to aspirate at least a portion of the sample dispensed by the first sample dispensing device into the transfer container from the transfer container located at the second transfer position; and the third cleaning device is used to perform a cleaning action on the transfer container located at the second transfer position, or on the transfer container located at the first transfer position, or on the transfer container moving from the second transfer position toward the first transfer position.
22. A sample analyzer, characterized in that: include: Transit container; A first sample allocation device is configured to collect at least a portion of the samples from a sample container located at a sampling position and allocate all or part of the collected samples to the transfer container; The second sample dispensing device is set independently of the first sample dispensing device, and the second sample dispensing device is used to aspirate at least a portion of the sample that has been dispensed into the transfer container by the first sample dispensing device from the transfer container, and to move the aspirated sample along a second transfer path to the first sample dispensing position and / or the second sample dispensing position, and to dispense all or part of the aspirated sample into the dry chemical detection carrier located at the first sample dispensing position and / or the formed element detection carrier located at the second sample dispensing position; A dry chemical detection device, the dry chemical detection device being used to perform dry chemical detection on the sample dispensed by the second sample dispensing device to the dry chemical detection carrier; A formed element detection device, wherein the formed element detection device is used to perform formed element detection on the sample dispensed by the second sample dispensing device to the formed element detection carrier; A controller, wherein the controller is at least used to control the operation of the first sample dispensing device, the second sample dispensing device, the dry chemical detection device, and the formed element detection device; The sampling bits and the second transfer path are set at intervals.
23. The sample analyzer as described in claim 22, characterized in that: The first sample dispensing device includes a first sample needle, a sampling tubing connected to the first sample needle, and a first suction-dispensing power component connected to the sampling tubing. The first suction-dispensing power component is used to drive the first sample needle to collect at least a portion of the sample from the sample container located at the sampling position, and to drive the first sample needle to dispense all or part of the collected sample into the transfer container. The second sample dispensing device includes a second sample needle, a suction tubing connected to the second sample needle, and a second suction-dispensing power component connected to the suction tubing. The second suction-dispensing power component is used to drive the second sample needle to aspirate at least a portion of the sample dispensed to the transfer container by the first sample dispensing device from the transfer container, and to drive the second sample needle to dispense all or part of the aspirated sample into a dry chemical detection carrier and / or a formed element detection carrier. Alternatively, the first sample dispensing device includes a first sample needle, a sampling tubing connected to the first sample needle, and a first suction-dispensing power component connected to the sampling tubing. The sampling tubing is also connected to the transfer container. The first suction-dispensing power component is used to drive the first sample needle to collect at least a portion of the sample from the sample container located at the sampling position, and to drive the sampling tubing to dispense all or part of the sample collected by the first sample needle into the transfer container. The second sample dispensing device includes a second sample needle, a suction tubing connected to the second sample needle, and a second suction-dispensing power component connected to the suction tubing. The second suction-dispensing power component is used to drive the second sample needle to draw at least a portion of the sample dispensed to the transfer container by the first sample dispensing device from the transfer container, and to drive the second sample needle to dispense all or part of the drawn sample into a dry chemical detection carrier and / or a formed element detection carrier.
24. A sample analyzer, characterized in that: include: Transit container; A first driving device is used to drive the transfer container to move between a first transfer position and a second transfer position; A first sample distribution device is configured to collect at least a portion of the samples from a sample container and distribute all or part of the collected samples to the transfer container located at the first transfer position; A second sample dispensing device is provided independently of the first sample dispensing device, and the second sample dispensing device is used to aspirate at least a portion of the sample that has been dispensed to the transfer container by the first sample dispensing device from the transfer container located at the second transfer position, and to dispense all or part of the aspirated sample to the detection carrier located at the sample dispensing position; A detection device for detecting a sample dispensed into the detection carrier by the second sample dispensing device; The controller is used to control the operation of the first driving device, the first sample distribution device, the second sample distribution device, and the detection device.