Automatic cell subpackaging workstation

Abstract

The utility model discloses an automatic cell subpackaging work station which comprises a sterile isolation system, a conveying device and a control system for controlling the whole work station to operate, the sterile isolation system is a closed system, and a parallel rotating hanging frame, a sterile mechanical arm and an automatic cryopreservation bag filling machine are sequentially arranged in the sterile isolation system. The conveying device is arranged outside the sterile isolation system, during use, the conveying device is in butt joint with the automatic cryopreservation bag filling machine through a conveying belt, filled cryopreservation bags are conveyed to the outside of the sterile isolation system, the parallel rotating hanging frame comprises a base, an upper hanging frame body and a lower hanging frame body, the upper hanging frame body is arranged above the lower hanging frame body in parallel, and the upper hanging frame body and the lower hanging frame body are connected through supporting columns. According to the full-automatic cell preparation subpackaging machine, full-closed filling is adopted, environmental microorganisms can be effectively isolated, pollution is prevented, the cell preparation filling process is fully automatic, the time is short, the yield is high, the cell activity is high, and the whole subpackaging process meets the GMP (Good Manufacturing Practice) requirements.

Description

Technical Field

[0001] The utility model relates to the technical field of cell subpackaging, in particular to an automatic cell subpackaging workstation. Background Art

[0002] Cell therapy is recognized by the medical and biological communities as a mainstream medical method to overcome diseases in the future. Stem cells are called "universal cells" and have strong regeneration and repair capabilities. They can differentiate into a variety of human cells, tissues and organs, and repair damaged cells or tissues. As an active drug, cells need to be filled into packaging containers (cryostorage bags) in large quantities after production and preparation. At present, the traditional processing method is manual filling, which not only takes a long time to operate and cannot guarantee cell viability, but also has the risk of cell contamination. Therefore, it is urgent to develop an automatic cell packaging system to solve the above technical problems.

[0003] In view of this, the present utility model is proposed. Utility Model Content

[0004] The purpose of the utility model is to provide an automatic cell filling workstation, which adopts fully enclosed filling, can effectively isolate environmental microorganisms and prevent pollution. The cell preparation filling process is fully automatic, short in time, high in yield, and high in cell viability. The entire filling process complies with GMP requirements, the entire operation process can be recorded and traced throughout, has broad application prospects, and is conducive to popularization and application.

[0005] In order to achieve the above-mentioned purpose, the utility model provides a cell automatic packaging workstation, including a sterile isolation system, a transport device and a control system for controlling the operation of the entire workstation. The sterile isolation system is a closed system, and a parallel rotating rack, a sterile robotic arm and an automatic cryopreservation bag filling machine are sequentially arranged inside the system. The transport device is arranged outside the sterile isolation system. When in use, the transport device and the automatic cryopreservation bag filling machine are connected through a conveyor belt to transport the filled cryopreservation bags to the outside of the sterile isolation system. The parallel rotating rack includes a base, an upper rack and a lower rack. The upper rack is arranged parallel to the upper part of the lower rack, and the two are connected by a pillar. The upper rack and the lower rack are both composed of an upper rack plate, a middle rack plate and a lower rack plate. The upper rack plate, the middle rack plate and the lower rack are annular, and a plurality of card slots for hanging cryo bags are arranged on their outer edges. A card block is connected to the top of the cryo bag, and the card block is connected to the top of the card slot to fix the cryo bag on the upper rack and the lower rack. The lower rack is connected to a servo motor, and the servo motor is fixed in the base. The lower rack and the upper rack are driven to rotate synchronously by the servo motor.

[0006] Preferably, the servo motor is connected to the lower bracket via a speed reducer, the hollow portion of the lower bracket is connected to an output housing, and the output shaft of the speed reducer is connected to the bottom of the output housing.

[0007] Preferably, a bearing cover is provided outside the reducer bearing of the reducer.

[0008] Preferably, the model of the sterile robotic arm is TX2-40 Stericlean CS9.

[0009] Preferably, the control system is a control system that can record the entire operation process of the workstation and achieve full traceability.

[0010] The utility model provides an automatic cell packaging workstation, which has the following beneficial effects.

[0011] 1. The utility model adopts closed filling, which can effectively isolate environmental microorganisms and prevent pollution.

[0012] 2. The packing process of the utility model is fully automatic, with short time, high yield and high cell activity.

[0013] 3. The parallel rotating rack of the utility model can rotate automatically, accurately position, and transport the cryopreservation bags in linkage with the sterile mechanical arm, with high working efficiency.

[0014] 4. The entire packaging process of the utility model complies with GMP requirements, and the entire operation process can be recorded and traced throughout. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 This is a schematic diagram of the structure of an automatic cell dispensing workstation provided by the utility model;

[0016] Figure 2 A three-dimensional diagram of a parallel rotating rack of an automatic cell dispensing workstation provided by the utility model;

[0017] Figure 3 A front view of a parallel rotating rack of an automatic cell dispensing workstation provided by the utility model;

[0018] Figure 4 for Figure 3 Sectional view at AA;

[0019] Figure 5 The utility model provides a schematic diagram of the structure of a lower rack of an automatic cell dispensing workstation.

[0020] In the figure:

[0021] 1. Aseptic isolation system 2. Automatic cryopreservation bag filling machine 3. Aseptic robotic arm 4. Parallel rotating rack 401. Upper rack 402. Upper rack plate 403. Middle rack plate 404. Lower rack plate 405. Cryopreservation bag 406. Pillar 408. Output cover 407. Lower rack 409. Reducer bearing 410. Bearing cover 411. Reducer 412. Servo motor 413. Base 414. Slot 415. Block 5. Transport device. DETAILED DESCRIPTION

[0022] The present invention will be further described below in conjunction with specific embodiments and drawings to help understand the content of the present invention.

[0023] like Figure 1 The figure shows a schematic diagram of the structure of an automatic cell packaging workstation provided by the utility model. The automatic cell packaging workstation includes a sterile isolation system 1, a transport device 5, and a control system for controlling the operation of the entire workstation. The sterile isolation system 1 is a closed system, and a parallel rotating rack 4, a sterile mechanical arm 3, and an automatic cryopreservation bag filler 2 are sequentially arranged inside the system. The transport device 5 is arranged outside the sterile isolation system 1. When in use, the transport device 5 is connected to the automatic cryopreservation bag filler 2 through a conveyor belt to transport the filled cryopreservation bag 405 to the outside of the sterile isolation system 1.

[0024] like Figure 2-Figure 5The figures are respectively a stereoscopic view, a front view, a cross-sectional view and a schematic diagram of the structure of the lower rack of a parallel rotating rack of an automatic cell dispensing workstation provided by the utility model. The parallel rotating rack 4 comprises a base 413, an upper rack 401 and a lower rack 407. The upper rack 401 is arranged parallel to the upper part of the lower rack 407, and the two are connected by a support 406. The upper rack 401 and the lower rack 407 are both composed of an upper rack plate 402, a middle rack plate 403 and a lower rack plate 404. The upper rack plate 402, the middle rack plate 403 and the lower rack 407 are annular, and a plurality of A slot 414 for hanging a cryopreservation bag 405, a block 415 is connected to the top of the cryopreservation bag 405, and the block 415 is connected to the top of the slot 414, so that the cryopreservation bag 405 is fixed on the upper hanger 401 and the lower hanger 407, and the lower hanger 407 is connected to a servo motor 412, and the servo motor 412 is fixed in the base 413, and the lower hanger 407 is driven by the servo motor 412 to rotate synchronously with the upper hanger 401. The servo motor 412 is connected to the lower hanger 407 through a reducer 411, and an output housing 408 is connected to the hollow of the lower hanger 407, and the output shaft of the reducer 411 is connected to the bottom of the output housing 408. A bearing housing 410 is provided outside the reducer bearing 409 of the reducer 411. The model of the sterile robot arm 3 is TX2-40 Stericlean CS9.

[0025] The working principle of the utility model is:

[0026] During operation, the cryopreservation bag 405 is manually hung on the upper rack 401 and the lower rack 407 of the parallel rotating rack 4, the sterile robotic arm 3 clamps the cryopreservation bag 405 and passes it to the automatic cryopreservation bag filling machine 2, the automatic cryopreservation bag filling machine 2 fills the cell preparation into the cryopreservation bag 405 and heat-seals it, and uses the conveyor belt to transport the sealed cryopreservation bag 405 to the transportation device 5 outside the sterile isolation system 1.

[0027] The utility model adopts closed filling, which can effectively isolate environmental microorganisms and prevent contamination. The subpackaging process of the utility model is fully automatic, short in time, high in yield, and high in cell viability. The parallel rotating rack 4 of the utility model can automatically rotate, accurately position, and transport the cryopreservation bag 405 in conjunction with the sterile mechanical arm 3, with high working efficiency. The entire subpackaging process of the utility model meets GMP requirements, and the entire operation process can be recorded and traced throughout.

[0028] This article uses specific examples to explain the concept of the utility model in detail, and the description of the above embodiments is only used to help understand the core idea of ​​the utility model. It should be pointed out that for ordinary technicians in this technical field, any obvious modifications, equivalent substitutions or other improvements made without departing from the concept of the utility model should be included in the scope of protection of the utility model.

Claims

1. A cell automatic packaging workstation, characterized in that: The invention comprises a sterile isolation system, a transport device and a control system for controlling the operation of the entire workstation. The sterile isolation system is a closed system, and a parallel rotating rack, a sterile robotic arm and an automatic cryopreservation bag filling machine are sequentially arranged inside the system. The transport device is arranged outside the sterile isolation system. When in use, the transport device and the automatic cryopreservation bag filling machine are connected through a conveyor belt to transport the filled cryopreservation bags to the outside of the sterile isolation system. The parallel rotating rack comprises a base, an upper rack and a lower rack. The upper rack is arranged parallel to the lower rack. Above the rack, the two are connected by a pillar, the upper rack and the lower rack are both composed of an upper rack plate, a middle rack plate and a lower rack plate, the upper rack plate, the middle rack plate and the lower rack are annular, and a plurality of card slots for hanging cryo bags are arranged on their outer edges, the top of the cryo bag is connected with a card block, and the card block is connected to the top of the card slot to fix the cryo bag on the upper rack and the lower rack, the lower rack is connected to a servo motor, and the servo motor is fixed in the base, and the lower rack is driven by the servo motor to rotate synchronously with the upper rack.

2. The automatic cell dispensing workstation according to claim 1, characterized in that: The servo motor is connected to the lower bracket via a speed reducer, an output housing is connected to the hollow portion of the lower bracket, and an output shaft of the speed reducer is connected to the bottom of the output housing.

3. The automatic cell dispensing workstation according to claim 2, characterized in that: A bearing cover is arranged outside the reducer bearing of the reducer.

4. The automatic cell dispensing workstation according to claim 3, characterized in that: The model of the sterile robotic arm is TX2-40 Stericlean CS9.

5. The automatic cell dispensing workstation according to claim 4, characterized in that: The control system is a control system that can record the entire operation process of the workstation and achieve full traceability.

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