Temperature control device

Abstract

The utility model provides a temperature control device which comprises a barrel-shaped reaction component, a temperature control component and a temperature control component, the barrel-shaped reaction component comprises a barrel body and a coil pipe wound on the outer surface of the barrel body, and the coil pipe serves as a circulation channel of heated / cooled materials; the temperature control assembly is arranged on the outer side of the barrel-shaped reaction part; the temperature sensor is in contact with the barrel-shaped reaction part or the temperature control assembly; the control unit is connected with the temperature sensor and controls the temperature control assembly to work based on the target temperature and the temperature detected by the temperature sensor. According to the utility model, a brand-new pharmaceutical research and development device is designed, the temperature control precision can be improved, and the chemical reaction is ensured to be carried out at a specified temperature.

Description

Technical Field

[0001] The utility model relates to the technical field of drug research and development, and in particular to a temperature control device. Background Art

[0002] When developing drugs, different chemical substances need to be introduced into chemical reaction equipment for chemical reactions. Chemical reactions generally need to be carried out at a specific ambient temperature, ranging from -20°C to 150°C. When a high temperature environment is required, most oil baths (heated by an induction cooker) are used; when a low temperature environment is required, an external air compressor (outside the fume hood) is used in combination with dry ice or liquid nitrogen blowing to maintain a low temperature environment. However, this temperature control method is not precise. The entire set of equipment cannot be placed in a fume hood. If a leak occurs, it is easy to contaminate the laboratory environment and pose a safety hazard.

[0003] Therefore, how to optimize the structure of chemical reaction equipment, improve temperature control accuracy, and ensure that the chemical reaction is carried out at a specified temperature is a problem that needs to be solved at present. Utility Model Content

[0004] The utility model aims to provide a temperature control device, which can improve the temperature control accuracy and ensure that the chemical reaction is carried out at a specified temperature.

[0005] In order to achieve the above object, the utility model provides a temperature control device, comprising:

[0006] A barrel-shaped reaction component, comprising a barrel body and a coil wound on the outer surface of the barrel body, the coil serving as a flow channel for heated / cooled substances;

[0007] A temperature control component is arranged outside the barrel-shaped reaction component;

[0008] a temperature sensor in contact with the barrel-shaped reaction component or the temperature control component;

[0009] The control unit is connected to the temperature sensor and controls the temperature control component to operate based on the target temperature and the temperature detected by the temperature sensor.

[0010] In an optional solution, the top and the bottom of the barrel-shaped reaction component are sealed, and the internal space enclosed by the barrel body is vacuum or filled with insulation material.

[0011] In an optional solution, the bottom of the barrel-shaped reaction component is sealed, and a closed hollow insulating barrel is provided inside the space enclosed by the barrel body, and a gap is provided between the side wall of the hollow insulating barrel and the barrel body.

[0012] In an optional solution, the gap is filled with insulating material.

[0013] In an alternative embodiment, the top of the barrel-shaped reaction component is open, and the top of the hollow heat-insulating barrel is sealed with the top of the barrel-shaped reaction component through a sealing structure; or,

[0014] The barrel-shaped reaction component has a detachable top cover to cover the hollow heat-insulating barrel within the space enclosed by the barrel body.

[0015] In an alternative embodiment, the temperature control assembly includes a sidewall temperature control assembly and a bottom temperature control assembly; the sidewall temperature control assembly is arranged on the outer periphery of the sidewall of the barrel-shaped reaction component, and the bottom temperature control assembly is arranged below the bottom of the barrel-shaped reaction component.

[0016] In an alternative embodiment, the sidewall temperature control assembly includes a fixed-end component and a moving-end component; the fixed-end component is arranged on one side of the barrel-shaped reaction component, and the moving-end component is arranged on the other side of the barrel-shaped reaction component, and the moving-end component can clamp or move away from the barrel-shaped reaction component.

[0017] In an alternative embodiment, both the fixed-end component and the moving-end component include a heat conduction plate and a plurality of temperature control units arranged outside the heat conduction plate. Each temperature control unit includes: a first TEC chip, a first heat sink, a first fan, and a "C"-shaped partition;

[0018] The first TEC chip is attached to the outer surface of the heat conduction plate, and the inner surface of the heat conduction plate is attached to the outer surface of the sidewall of the barrel-shaped reaction component;

[0019] The first heat sink is arranged on the outer surface of the first TEC chip;

[0020] The "C"-shaped partition covers the first heat sink, and the area enclosed by it and the first heat sink forms a first air duct; the air outlet direction of the first air duct is from bottom to top, and the first fan is arranged at the upper end of the first air duct.

[0021] In an alternative embodiment, the bottom temperature control assembly includes a bottom plate, a second TEC chip, a second heat sink, a second fan, and a second air duct;

[0022] The upper surface of the bottom plate is attached to the bottom of the barrel-shaped reaction component;

[0023] The second TEC chip is arranged on the lower surface of the bottom plate;

[0024] The second heat sink is arranged below the second TEC chip;

[0025] The second air duct is "L"-shaped, its horizontal part is arranged below the second heat sink, and the opening of the vertical part faces upward;

[0026] The second fan is disposed at an end of the transverse portion, and the second air duct takes in air from the second fan and discharges air upward.

[0027] In an optional solution, the outer surface of the barrel body has a spirally ascending groove, and the coil is embedded in the groove.

[0028] The beneficial effects of the utility model are:

[0029] The temperature control device of the utility model can improve the temperature control accuracy of heated / cooled substances and ensure that chemical reactions are carried out at a specified temperature during pharmaceutical research and development.

[0030] Furthermore, by providing the side wall temperature control component and the bottom temperature control component, the temperature control component and the barrel-shaped reaction component have a larger contact area, which can speed up the temperature adjustment of the barrel-shaped reaction component.

[0031] Furthermore, the side wall temperature control assembly is split into a fixed end component and a moving end component, so that the barrel-shaped reaction component can be easily disassembled;

[0032] Furthermore, by using TEC sheets as the main components for temperature regulation, cooling and heating can be achieved by controlling the current direction of the TEC sheets, and precise temperature regulation can be achieved by controlling the current size of the TEC sheets, thereby improving the temperature regulation accuracy.

[0033] Furthermore, a heat insulation structure is provided inside the space enclosed by the barrel-shaped reaction component, which can reduce the speed of heat conduction and improve the efficiency of heating / cooling.

[0034] Furthermore, by providing the first air duct and the second air duct, the exhaust efficiency of hot air during the refrigeration process is improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] The above and other objects, features and advantages of the present invention will become more apparent through a more detailed description of exemplary embodiments of the present invention in conjunction with the accompanying drawings, in which the same reference numerals generally represent the same components.

[0036] Figure 1 It is a structural schematic diagram of a temperature control device in one embodiment of the utility model.

[0037] Figure 2 It is a partial structural schematic diagram of a temperature control device in one embodiment of the utility model.

[0038] Figure 3 It is a schematic structural diagram of a barrel-shaped reaction component in one embodiment of the utility model.

[0039] Figure 4This is a schematic structural diagram of the side wall temperature control component in an embodiment of the present utility model.

[0040] Figure 5 This is a schematic structural diagram of the second air duct in an embodiment of the present utility model.

[0041] Figure 6 This is a schematic structural diagram of the hollow heat insulation barrel in an embodiment of the present utility model.

[0042] Explanation of reference numerals:

[0043] 1 - Barrel-shaped reaction component; 2 - Side wall temperature control component; 20 - Heat conduction plate; 21 - Fixed end component; 22 - Moving end component; 23 - First heat sink; 24 - First fan; 25 - "C"-shaped partition board; 26 - First TEC chip; 27 - First air duct, 3 - Bottom temperature control component; 31 - Second air duct; 32 - Second fan; 4 - Hollow heat insulation barrel; 5 - Quick clamp. Detailed implementation manners

[0044] The following further elaborates on the present utility model in detail in conjunction with the accompanying drawings and specific embodiments. According to the following description and drawings, the advantages and features of the present utility model will be clearer. However, it should be noted that the concept of the technical solution of the present utility model can be implemented in various different forms and is not limited to the specific embodiments described herein. The accompanying drawings are all in very simplified forms and use non-precise scales, only for conveniently and clearly assisting in explaining the purpose of the embodiments of the present utility model.

[0045] It should be understood that when an element or layer is referred to as "on...", "adjacent to...", "connected to" or "coupled to" another element or layer, it can be directly on, adjacent to, connected or coupled to the other element or layer, or there may be intervening elements or layers. In contrast, when an element is referred to as "directly on...", "directly adjacent to...", "directly connected to" or "directly coupled to" another element or layer, there are no intervening elements or layers. It should be understood that although the terms first, second, third, etc. may be used to describe various elements, components, regions, layers and / or parts, these elements, components, regions, layers and / or parts should not be limited by these terms. These terms are only used to distinguish one element, component, region, layer or part from another element, component, region, layer or part. Therefore, without departing from the teachings of the present utility model, the first element, component, region, layer or part discussed below may be referred to as the second element, component, region, layer or part.

[0046] Spatially relative terms such as "under," "below," "below," "under," "above," "above," etc., may be used herein for ease of description to describe the relationship of an element or feature shown in the figures to other elements or features. It should be understood that in addition to the orientations shown in the figures, the spatially relative terms are intended to include different orientations of the device in use and operation. For example, if the device in the accompanying drawings is flipped, then the elements or features described as "under other elements" or "under" or "under" will be oriented as "on" the other elements or features. Therefore, the exemplary terms "under" and "under" may include both upper and lower orientations. The device may be oriented otherwise (rotated 90 degrees or other orientations) and the spatial descriptors used herein are interpreted accordingly.

[0047] The purpose of the terms used herein is only to describe specific embodiments and is not intended to be a limitation of the present invention. When used herein, the singular forms "one", "an" and "said / the" are also intended to include plural forms, unless the context clearly indicates otherwise. It should also be understood that the terms "consisting of" and / or "comprising" when used in this specification determine the presence of the features, integers, steps, operations, elements and / or parts, but do not exclude the presence or addition of one or more other features, integers, steps, operations, elements, parts and / or groups. When used herein, the term "and / or" includes any and all combinations of the relevant listed items.

[0048] Example

[0049] Reference Figures 1 to 6 , this embodiment provides a temperature control device, including:

[0050] A barrel-shaped reaction component 1, the barrel-shaped reaction component 1 comprises a barrel body and a coil wound on the outer surface of the barrel body, the coil serving as a flow channel for heated / cooled substances;

[0051] A temperature control component is arranged outside the barrel-shaped reaction component 1;

[0052] A temperature sensor, in contact with the barrel-shaped reaction component 1 or the temperature control component;

[0053] A control unit is connected to the temperature sensor and controls the temperature control component to operate based on a target temperature and a temperature detected by the temperature sensor.

[0054] Specifically, a two-way or three-way joint can be connected to the inlet of the coil to allow different chemical substances to enter. In the present embodiment, the barrel-shaped reaction component 1 is cylindrical, the coil is only wound around the side wall, and the bottom wall is not provided with a coil. In other embodiments, the barrel-shaped reaction component can also be rectangular. In the present embodiment, the outer surface of the barrel body has a spirally ascending groove, and the coil is embedded in the groove. In the preferred embodiment, the coil fills the entire groove, and the coil height is flush with the outer surface of the barrel body, so that the temperature control component, the coil and the barrel body are all tightly fitted to improve thermal conductivity. In the present embodiment, the coil can accommodate 50ml of liquid.

[0055] In this embodiment, the top of the barrel-shaped reaction component 1 is open and the bottom is sealed. A closed hollow insulated barrel 4 is provided inside the space surrounded by the barrel body to discharge the air in the middle of the barrel-shaped reaction component. There is a gap between the side wall of the hollow insulated barrel and the barrel body. The gap can be filled with air or insulation material. The gap should not be too large, otherwise it will increase heat loss, and the gap should not be too small, otherwise it will be unfavorable for the hollow insulated barrel 4 to be taken out. The hollow insulated barrel 4 can be an integral structure or a split structure. In this embodiment, the hollow insulated barrel 4 is a split structure, including a barrel body and a barrel cover. In an optional embodiment, a removable top cover is also provided above the barrel-shaped reaction component to cover the hollow insulated barrel 4 in the space surrounded by the barrel body. In other embodiments, the top cover may not be provided, and the top of the hollow insulated barrel and the top of the barrel-shaped reaction component are sealed by a sealing structure. In another example, the top and bottom of the barrel-shaped reaction component are sealed, and the internal space surrounded by the barrel body is vacuum or filled with insulation material. All of the above measures are aimed at reducing the heat conduction rate and improving the efficiency of heating / cooling.

[0056] In this embodiment, the temperature control component includes a side wall temperature control component 2 and a bottom temperature control component 3; wherein the side wall temperature control component 2 is arranged on the outer periphery of the side wall of the barrel-shaped reaction component 1, wrapping the barrel-shaped reaction component 1 from the side, and the bottom temperature control component 3 is arranged below the bottom of the barrel-shaped reaction component 1. By arranging the side wall temperature control component 2 and the bottom temperature control component 3, the temperature control component and the barrel-shaped reaction component 1 have a larger contact area, which can speed up the temperature adjustment of the barrel-shaped reaction component.

[0057] The side wall temperature control component 2 includes a fixed end component 21 and a moving end component 22; the fixed end component 21 is arranged on one side of the barrel-shaped reaction component 1, the moving end component 22 is arranged on the other side of the barrel-shaped reaction component 1, and the moving end component can clamp or move away from the barrel-shaped reaction component 1. In this embodiment, the fixed end component 21 and the moving end component 22 each account for half of the side wall of the barrel-shaped reaction component. The moving end component 22 can achieve the positioning and clamping between the moving end component 22 and the barrel-shaped reaction component 1 through a quick clamp 5 or other manual fixtures or pneumatic fixtures. This detachable way of the moving end component can facilitate the disassembly of the barrel-shaped reaction component 1 and the replacement of the coiled pipe.

[0058] In this embodiment, both the fixed end component 21 and the moving end component 22 include a heat conducting plate and a plurality of temperature control units arranged outside the heat conducting plate 20 (both the fixed end component and the moving end component are provided with 3 temperature control units in the figure); each temperature control unit includes: a first TEC chip 26, a first heat sink 23, a first fan 24 and a "C"-shaped partition 25; the first TEC chip 26 is attached to the outer surface of the heat conducting plate 20, and the inner surface of the heat conducting plate 20 is attached to the outer surface of the side wall of the barrel-shaped reaction component 1; the first heat sink 23 is arranged on the outer surface of the first TEC chip 26; the "C"-shaped partition 25 covers the first heat sink 23, and the area surrounded by the "C"-shaped partition 25 and the first heat sink 23 forms a first air duct 27; the air outlet direction of the first air duct 27 is from bottom to top, and the first fan 24 is arranged at the upper end of the first air duct 27.

[0059] It should be noted that in this embodiment, both the first TEC chip and the second TEC chip are semiconductor thermoelectric coolers (ThermoElectric Cooler, abbreviated as TEC), which are made by using the Peltier effect of semiconductor materials. The Peltier effect means that when an electric current flows through an electric couple composed of two different semiconductor materials, one end of the electric couple releases heat and the other end absorbs heat. If the direction of the current flowing in is changed, the heat-releasing and heat-absorbing ends will also be exchanged accordingly, and its structure and working process will not be elaborated here. In this implementation, the first TEC chip and the second TEC chip are off-the-shelf molded products, and each temperature control unit of the side wall temperature control component 2 includes 4 first TEC chips. In other embodiments, the TEC chip can be improved, such as increasing the length and / or width of the TEC chip and reducing the number of TEC chips used.

[0060] In this embodiment, the inner surface of the heat conducting plate 20 is coated with a flexible heat conducting material, such as silica gel, which can avoid rigid contact between the heat conducting plate 20 and the barrel-shaped reaction component 1, and enhance the fitting degree between the two, as well as the wrapping property and heat conductivity. In this embodiment, a heat conducting layer, such as a graphite sheet, is provided between the first TEC chip and the first heat sink 23. This can make the first TEC chip and the first heat sink 23 fit tightly and improve the heat conduction efficiency.

[0061] In this embodiment, the bottom temperature control component 3 includes a bottom plate, a second TEC sheet, a second heat sink, a second fan 32 and a second air duct 31; the upper surface of the bottom plate is in contact with the bottom of the barrel-shaped reaction component 1; the second TEC sheet is arranged on the lower surface of the bottom plate; the second heat sink is arranged below the second TEC sheet; the second air duct 31 is "L"-shaped, and its transverse portion is arranged below the second heat sink, and the opening of the longitudinal portion faces upward; the second fan 32 is arranged at the end of the transverse portion, and the second air duct 31 takes in air from the second fan 32 and discharges air upward. That is, the second air duct includes a horizontal direction and a vertical direction, and the second heat sink is arranged in the horizontal direction of the air duct. This embodiment designs the first air duct and the second air duct, which can limit the wind direction of the air inlet and outlet, increase the power of the heat sink, and then increase the power of the first TEC sheet and the first TEC sheet.

[0062] In this embodiment, a temperature sensor is provided at the heat conducting plate 20 and the bottom plate corresponding to each temperature control unit. The temperature sensor is connected to the control unit to monitor the temperature at multiple positions in real time. The current direction and current magnitude of the first TEC sheet / second TEC sheet, as well as the power of the first fan and the second fan are controlled by the relationship between the detected temperature and the target temperature. For example, in the heating stage, a large current is passed, and after the temperature reaches the target temperature, the current is reduced. In the temperature maintenance stage, a small current can be maintained for all first TEC sheets / second TEC sheets, and after reaching the target temperature, the number of working temperature control units can be flexibly adjusted, such as from 6 groups to 2 groups (suitable for chemical reactions that are not sensitive to temperature). When heat dissipation is required, the fan is turned on and the power of the fan is controlled as needed.

[0063] This embodiment uses the TEC sheet as the main component for temperature control. Cooling and heating can be achieved by controlling the current direction of the TEC sheet. The temperature can be precisely adjusted by controlling the current size of the TEC sheet, thereby improving the temperature adjustment accuracy.

[0064] The above description is only a description of the preferred embodiment of the utility model, and is not any limitation on the scope of the utility model. Any changes and modifications made by ordinary technicians in the field of the utility model based on the above disclosure shall fall within the scope of protection of the claims.

Claims

1. A temperature control device, characterized in that: Comprising: A barrel-shaped reaction component, which includes a barrel body and a coiled pipe wound around the outer surface of the barrel body. The coiled pipe serves as a circulation channel for the heat-absorbing / cooling substance. A temperature control assembly, arranged on the outside of the barrel-shaped reaction component. A temperature sensor, in contact with the barrel-shaped reaction component or the temperature control assembly. A control unit, connected to the temperature sensor, and based on the target temperature and the temperature detected by the temperature sensor, controls the operation of the temperature control assembly.

2. The temperature control device according to claim 1, characterized in that: Both the top and bottom of the barrel-shaped reaction component are sealed, and the internal space enclosed by the barrel body is vacuum or filled with heat-insulating material.

3. The temperature control device according to claim 1, characterized in that: The bottom of the barrel-shaped reaction component is sealed, and a closed hollow heat-insulating barrel is provided inside the space enclosed by the barrel body. There is a gap between the side wall of the hollow heat-insulating barrel and the barrel body.

4. The temperature control device according to claim 3, characterized in that: The gap is filled with heat-insulating material.

5. The temperature control device according to claim 3, characterized in that: The top of the barrel-shaped reaction component is open, and the top of the hollow heat-insulating barrel is sealed with the top of the barrel-shaped reaction component through a sealing structure; or, The barrel-shaped reaction component has a detachable top cover to cover the hollow heat-insulating barrel inside the space enclosed by the barrel body.

6. The temperature control device according to any one of claims 2 to 5, characterized in that: The temperature control assembly includes a side wall temperature control component and a bottom temperature control component; the side wall temperature control component is arranged on the outer periphery of the side wall of the barrel-shaped reaction component, and the bottom temperature control component is arranged below the bottom of the barrel-shaped reaction component.

7. The temperature control device according to claim 6, characterized in that: The side wall temperature control component includes a fixed-end component and a moving-end component; the fixed-end component is arranged on one side of the barrel-shaped reaction component, and the moving-end component is arranged on the other side of the barrel-shaped reaction component, and the moving-end component can clamp or move away from the barrel-shaped reaction component.

8. The temperature control device according to claim 7, characterized in that: Both the fixed-end component and the moving-end component include a heat-conducting plate and a plurality of temperature control units arranged outside the heat-conducting plate. Each temperature control unit includes: a first TEC chip, a first heat sink, a first fan, and a "C"-shaped partition. The first TEC chip is attached to the outer surface of the heat-conducting plate, and the inner surface of the heat-conducting plate is attached to the outer surface of the side wall of the barrel-shaped reaction component. The first heat sink is arranged on the outer surface of the first TEC chip. The "C"-shaped partition covers the first heat sink, and the area enclosed with the first heat sink forms a first air duct; the air outlet direction of the first air duct is from bottom to top, and the first fan is arranged at the upper end of the first air duct.

9. The temperature control device according to claim 6, characterized in that: The bottom temperature control component includes a bottom plate, a second TEC chip, a second heat sink, a second fan, and a second air duct. The upper surface of the bottom plate is attached to the bottom of the barrel-shaped reaction component. The second TEC chip is arranged on the lower surface of the bottom plate. The second heat sink is arranged below the second TEC chip. The second air duct is in an "L" shape, its horizontal part is arranged below the second heat sink, and the opening of the vertical part faces upward. The second fan is arranged at the end of the horizontal part, and the second air duct intakes air from the second fan and blows air upward.

10. The temperature control device according to claim 1, characterized in that: The outer surface of the barrel body has a helically rising groove, and the coiled pipe is embedded in the groove.

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