Hydrogel patch with oral cavity restoration function

Abstract

The utility model relates to a hydrogel patch with an oral cavity restoration function, which comprises a gel layer, a composite layer arranged at the top of the gel layer, a polyvinyl alcohol layer arranged at the top of the composite layer, an anti-inflammatory layer arranged at the top of the polyvinyl alcohol layer, a polyethylene glycol diacrylate layer arranged at the top of the anti-inflammatory layer, and an anti-inflammatory layer arranged at the top of the polyethylene glycol diacrylate layer. A plurality of placing grooves are formed in the top of the polyvinyl alcohol layer, and micro-nano particles are arranged in inner cavities of the placing grooves. The oral cavity patch has the advantages of being good in stability and good in treatment effect, in the actual using process, the gel layer and the double-layer thiolated alginate layer are additionally arranged and used for providing enhanced adhesion, it is ensured that the patch can be tightly attached to the interior of the oral cavity, stability is kept, materials with higher adhesion are introduced, and the effect is good. Therefore, the patch can be firmly attached to a damaged part even in a humid environment; and a lasting moisturizing effect is provided through the hyaluronic acid layer.

Description

Technical Field

[0001] The utility model relates to the technical field of oral repair, in particular to a hydrogel patch with oral repair function. Background Art

[0002] Oral restoration, commonly known as dental prosthesis, is mainly aimed at the treatment of tooth defects and missing teeth, such as inlays, full crowns, dentures, etc. It also includes the use of artificial restorations to treat periodontal disease, temporomandibular joint disease and maxillofacial tissue defects, such as occlusal splints, periodontal splints, prostheses, artificial eyes, artificial ears, artificial noses, etc.

[0003] When applying hydrogel patches in oral treatment, first of all, one of the challenges faced when the hydrogel patch is applied to the inside of the patient's mouth is the abundant saliva secretion in the mouth. Saliva not only helps to moisten and clean the mouth, but it may become a potential obstacle when it comes into contact with the hydrogel patch. Due to the lubricating properties of saliva, it may make it difficult for the patch to fit stably on the damaged area, thereby affecting the therapeutic effect of the patch. Secondly, in addition to the stability of the patch in the mouth, the comfort of the patient is also an important factor to consider. The mouth is a highly sensitive area. Therefore, the hydrogel patch needs to have excellent therapeutic effects, such as anti-inflammatory and analgesic effects, to cope with the different symptoms and needs of patients.

[0004] Therefore, there is an urgent need for a hydrogel patch with oral repair function to solve the above problems. Utility Model Content

[0005] The purpose of the utility model is to provide a hydrogel patch with oral repair function, which has the advantages of good stability and good treatment effect, and solves the problems raised by the above-mentioned background technology.

[0006] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a hydrogel patch with oral repair function, comprising: a gel layer, a composite layer is arranged on the top of the gel layer, a polyvinyl alcohol layer is arranged on the top of the composite layer, an anti-inflammatory layer is arranged on the top of the polyvinyl alcohol layer, a polyethylene glycol diacrylate layer is arranged on the top of the anti-inflammatory layer, a plurality of placement grooves are opened on the top of the polyvinyl alcohol layer, micro-nano particles are arranged in the inner cavity of the placement grooves, and an acetaminophen layer is arranged in the inner cavity of the micro-nano particles.

[0007] The gel layer, the composite layer, the polyvinyl alcohol layer, the anti-inflammatory layer and the polyethylene glycol diacrylate layer together constitute a hydrogel patch.

[0008] A skeleton is arranged inside the polyvinyl alcohol layer.

[0009] Furthermore, as a preferred embodiment of the utility model, the skeleton comprises locking block one and locking block two, the locking block one and locking block two are staggered, the locking block one and locking block two are in contact with each other, the locking block one and locking block two are arranged in a rectangle, and are distributed around the micro-nano particles, and the skeleton is made of compound curcumin material.

[0010] Furthermore, as a preferred embodiment of the present invention, a patch backing is provided at the bottom of the gel layer, and the area of ​​the patch backing is larger than the area of ​​the gel layer.

[0011] Furthermore, as a preferred embodiment of the present invention, a plurality of through holes are provided on one side of the gel layer and the composite layer.

[0012] Furthermore, as a preferred embodiment of the present invention, the composite layer comprises a double-layer thiolated alginate layer, and a hyaluronic acid layer is disposed on one side of the double-layer thiolated alginate layer.

[0013] Furthermore, as a preferred embodiment of the present invention, the anti-inflammatory layer includes a prednisone layer, and a glucocorticoid layer is disposed on one side of the prednisone layer.

[0014] Beneficial effects. The technical solution of the present application has the following technical effects: the utility model has the advantages of good stability and good therapeutic effect. In actual use, a gel layer and a double-layer thiolated alginate layer are added to provide enhanced adhesion, ensuring that the patch can fit tightly in the oral cavity and maintain stability. Materials with stronger adhesion are introduced to ensure that the patch can be firmly attached to the damaged part even in a humid environment; a long-lasting moisturizing effect is provided through the hyaluronic acid layer, which helps to keep the oral environment moist and promote tissue repair; the hydrogel patch provides a strong anti-inflammatory effect through the prednisone layer and the glucocorticoid layer, which can quickly control the inflammatory response in the oral cavity and create a good environment for tissue repair; the hydrogel patch provides analgesic effect through the acetaminophen layer wrapped inside the micro-nanoparticles, which can relieve the patient's pain.

[0015] It should be appreciated that all combinations of the foregoing concepts, as well as additional concepts described in greater detail below, may be considered part of the inventive subject matter of the present disclosure, provided such concepts are not mutually inconsistent. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings:

[0017] Figure 1 It is a schematic diagram of the structure of the utility model;

[0018] Figure 2 This is a three-dimensional schematic diagram of the hydrogel patch of the utility model in a disassembled state;

[0019] Figure 3 For this utility model Figure 2 A partial enlarged view of middle A;

[0020] Figure 4 This is a schematic diagram of the three-dimensional structure of the polyvinyl alcohol layer of the utility model;

[0021] Figure 5 It is a schematic diagram of the three-dimensional structure of the micro-nano particles, acetaminophen layer and skeleton of the utility model;

[0022] Figure 6 It is a schematic diagram of the local structure of the composite layer of the utility model;

[0023] Figure 7 This is a schematic diagram of the local structure of the anti-inflammatory layer of the utility model.

[0024] In the figure, the meanings of the various reference numerals are as follows: 1. hydrogel patch; 11. gel layer; 12. composite layer; 121. double-layer thiolated alginate layer; 122. hyaluronic acid layer; 13. polyvinyl alcohol layer; 14. anti-inflammatory layer; 141. prednisone layer; 142. glucocorticoid layer; 15. polyethylene glycol diacrylate layer; 16. placement groove; 17. micro-nanoparticles; 18. acetaminophen layer; 2. skeleton; 21. locking block one; 22. locking block two; 3. patch backing; 4. through hole. DETAILED DESCRIPTION

[0025] In order to further explain the technical means and effects adopted by the present invention to achieve the predetermined purpose of the utility model, the specific implementation method, structure, characteristics and effects of the present invention are described in detail below in combination with the accompanying drawings and preferred embodiments.

[0026] As attached Figure 1 To Attachment Figure 7 As shown: This embodiment provides a hydrogel patch with oral repair function, including: a gel layer 11, a composite layer 12 is arranged on the top of the gel layer 11, a polyvinyl alcohol layer 13 is arranged on the top of the composite layer 12, an anti-inflammatory layer 14 is arranged on the top of the polyvinyl alcohol layer 13, a polyethylene glycol diacrylate layer 15 is arranged on the top of the anti-inflammatory layer 14, a plurality of placement grooves 16 are opened on the top of the polyvinyl alcohol layer 13, micro-nano particles 17 are arranged in the inner cavity of the placement grooves 16, and an acetaminophen layer 18 is arranged in the inner cavity of the micro-nano particles 17.

[0027] The gel layer 11 , the composite layer 12 , the polyvinyl alcohol layer 13 , the anti-inflammatory layer 14 and the polyethylene glycol diacrylate layer 15 together constitute the hydrogel patch 1 .

[0028] The skeleton 2 is provided inside the polyvinyl alcohol layer 13 .

[0029] Specifically, the skeleton 2 includes a locking block 1 21 and a locking block 22, the locking block 1 21 and the locking block 2 22 are staggered, the locking block 1 21 and the locking block 2 22 are in contact with each other, the locking block 1 21 and the locking block 2 22 are arranged in a rectangle, and are distributed around the micro-nano particles 17, and the skeleton 2 is made of the compound curcumin material.

[0030] In this embodiment: through the coordinated use of locking block 1 21 and locking block 2 22, support and stability are provided for the entire hydrogel patch 1, ensuring that the patch can maintain a certain shape and structure in the oral cavity, so as to better fit the damaged area, thereby ensuring that the drug can be released to the damaged area.

[0031] Specifically, a patch backing 3 is disposed at the bottom of the gel layer 11 , and the area of ​​the patch backing 3 is larger than the area of ​​the gel layer 11 .

[0032] In this embodiment: the patch backing 3 is provided to protect the patch and facilitate the use of the patch.

[0033] Specifically, a plurality of through holes 4 are formed on one side of the gel layer 11 and the composite layer 12 .

[0034] In this embodiment, the through hole 4 is provided to help release and diffusion of the drug in the patch, promote contact and absorption of the drug with oral tissue, and improve oral repair and treatment effects.

[0035] Specifically, the composite layer 12 includes a double-layer thiolated alginate layer 121 , and a hyaluronic acid layer 122 is disposed on one side of the double-layer thiolated alginate layer 121 .

[0036] In this embodiment: through the coordinated use of the double-layer thiolated alginate layer 121 and the hyaluronic acid layer 122, the double-layer thiolated alginate layer 121 increases the adhesion between the patch and the oral tissue, and also helps to stimulate the growth and regeneration of cells, which is very important for the repair and healing process of the oral tissue, while the hyaluronic acid layer 122 helps to keep the oral environment moist and promote tissue repair. Hyaluronic acid can also promote the proliferation and differentiation of epidermal cells, and scavenge oxygen free radicals, which helps to prevent and repair skin damage. In the oral environment, these effects are also applicable and can promote the repair and regeneration of damaged oral mucosa.

[0037] Specifically, the anti-inflammatory layer 14 includes a prednisone layer 141 , and a glucocorticoid layer 142 is disposed on one side of the prednisone layer 141 .

[0038] In this embodiment: through the coordinated use of the prednisone layer 141 and the glucocorticoid layer 142, the prednisone layer 141 is used to inhibit the production and release of inflammatory mediators, thereby reducing the inflammatory response, and the glucocorticoid layer 142 can quickly control inflammation and create a good environment for tissue repair.

[0039] The working principle and use process of this utility model:

[0040] When in use, the gel layer 11 serves as the base layer of the entire patch, providing stability and support for the patch so that the patch can fit tightly to the damaged part in the oral cavity; the composite layer 12 is located on top of the gel layer 11, providing the patch with additional adhesion and moisturizing functions, and the double-layer thiolated alginate layer 121 increases the adhesion between the patch and the oral tissue, and also helps stimulate cell growth and regeneration, which is very important for the repair and healing process of oral tissue, while the hyaluronic acid layer 122 helps keep the oral environment moist and promotes tissue repair. Hyaluronic acid can also promote the proliferation and differentiation of epidermal cells, as well as scavenge oxygen free radicals, which helps prevent and repair skin damage. In the oral environment, these effects are also applicable and can promote the repair of damaged oral mucosa. The polyvinyl alcohol layer 13 is used as a carrier of the micro-nano particles 17, and the placement groove 16 opened inside the polyvinyl alcohol layer 13 is used to store the micro-nano particles 17. The acetaminophen layer 18 wrapped inside the micro-nano particles 17 releases the drug when needed to provide analgesic effect; the anti-inflammatory layer 14 is arranged above the anti-inflammatory layer 14, and contains a prednisone layer 141 and a glucocorticoid layer 142. The prednisone layer 141 is used to inhibit the production and release of inflammatory mediators, thereby reducing the inflammatory response. The glucocorticoid layer 142 can quickly control inflammation and create a good environment for tissue repair; the polyethylene glycol diacrylate layer 15 is a protective functional layer, which provides a certain degree of protection and isolation to prevent further damage to the damaged tissue by external stimuli, and can provide comfort for the patch.

[0041] The above are only preferred embodiments of the present invention, and are not intended to limit the present invention in any form. Although the present invention has been disclosed as a preferred embodiment as above, it is not intended to limit the present invention. Any technical personnel in this field can make some changes or modify the technical contents disclosed above into equivalent embodiments without departing from the scope of the technical solution of the present invention. However, any brief modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention are still within the scope of the technical solution of the present invention.

Claims

1. A hydrogel patch with oral repair function, comprising: The gel layer (11) is characterized in that: a composite layer (12) is arranged on the top of the gel layer (11), a polyvinyl alcohol layer (13) is arranged on the top of the composite layer (12), an anti-inflammatory layer (14) is arranged on the top of the polyvinyl alcohol layer (13), a polyethylene glycol diacrylate layer (15) is arranged on the top of the anti-inflammatory layer (14), a plurality of placement grooves (16) are opened on the top of the polyvinyl alcohol layer (13), micro-nano particles (17) are arranged in the inner cavity of the placement grooves (16), and an acetaminophen layer (18) is arranged in the inner cavity of the micro-nano particles (17); The gel layer (11), the composite layer (12), the polyvinyl alcohol layer (13), the anti-inflammatory layer (14) and the polyethylene glycol diacrylate layer (15) together constitute a hydrogel patch (1); A skeleton (2) is arranged inside the polyvinyl alcohol layer (13).

2. The hydrogel patch with oral repair function according to claim 1, characterized in that: The skeleton (2) comprises a locking block 1 (21) and a locking block 2 (22), wherein the locking block 1 (21) and the locking block 2 (22) are arranged in a staggered manner, the locking block 1 (21) and the locking block 2 (22) are in contact with each other, the locking block 1 (21) and the locking block 2 (22) are arranged in a rectangular shape, and are distributed around the micro-nano particles (17), and the skeleton (2) is made of a compound curcumin material.

3. The hydrogel patch with oral repair function according to claim 1, characterized in that: A patch backing (3) is provided at the bottom of the gel layer (11), and the area of ​​the patch backing (3) is larger than the area of ​​the gel layer (11).

4. The hydrogel patch with oral repair function according to claim 1, characterized in that: A plurality of through holes (4) are provided on one side of the gel layer (11) and the composite layer (12).

5. The hydrogel patch with oral repair function according to claim 1, characterized in that: The composite layer (12) comprises a double-layer thiolated alginate layer (121), and a hyaluronic acid layer (122) is disposed on one side of the double-layer thiolated alginate layer (121).

6. The hydrogel patch with oral repair function according to claim 1, characterized in that: The anti-inflammatory layer (14) includes a prednisone layer (141), and a glucocorticoid layer (142) is disposed on one side of the prednisone layer (141).

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