Connecting part for freeze-drying monitoring of lumbrukinase

Abstract

The utility model provides a connecting part for lumbrukinase freeze-drying monitoring, which comprises a vacuumizing pipeline used for connecting a drying box and a monitoring device, the vacuumizing pipeline comprises a first pipeline with one end used for connecting the drying box and a second pipeline with one end connected with the first pipeline and the other end connected with the monitoring device, a filter part is arranged between the first pipeline and the second pipeline and comprises a steel ring and a filter screen arranged on the steel ring, the outer side of the filter screen is fixedly connected with the inner ring side wall of the steel ring, one side of the steel ring extends outwards to form a limiting ring edge, the inner wall of the end, close to the first pipeline, of the second pipeline is sunken inwards to form a groove, and the groove is matched with the outer diameter of the steel ring and used for containing the steel ring. An annular groove matched with the limiting ring edge is formed in the bottom of the groove. According to the connecting part for the freeze-drying monitoring of the lumbrukinase, the problem that a connecting part for the freeze-drying monitoring of the lumbrukinase, which is high in sealing performance and capable of preventing impurities from entering a freeze-drying mass spectrometer, is lacked in the prior art is solved.

Description

Technical Field

[0001] The utility model relates to the technical fields of bioengineering and enzyme preparation, in particular to a connecting component for monitoring lumbrokinase freeze-drying. Background Art

[0002] Lumbrokinase is a group of proteins extracted from special earthworms and requires freeze-drying during production.

[0003] In the prior art, freeze-drying mass spectrometers are commonly used to monitor the freeze-drying process of lumbrokinase. Currently, the pipes connecting the freeze dryer and the freeze-drying mass spectrometer are typically connected using a metal bellows and a clamp. This clamp can easily loosen, leading to contamination of the lumbrokinase. Furthermore, the clamp's securement method provides poor sealing, potentially drawing impurities from the air outside the freeze dryer into the freeze-drying mass spectrometer, affecting the monitor's accuracy. Utility Model Content

[0004] Based on this, the purpose of the present invention is to provide a connecting component for monitoring the freeze-drying of lumbrokinase, aiming to solve the problem in the prior art of the lack of a connecting component for monitoring the freeze-drying of lumbrokinase that has high sealing performance and prevents impurities from entering the freeze-drying mass spectrometer.

[0005] The utility model proposes a connecting component for monitoring the freeze-drying of lumbrokinase, including a vacuum pipeline for connecting a drying box and a monitoring device, the vacuum pipeline including a first pipe for connecting to the drying box at one end, and a second pipe connected to the first pipe at one end and the monitoring device at the other end, a filter element is provided between the first pipe and the second pipe, the filter element includes a steel ring and a filter screen arranged on the steel ring, the outer side of the filter screen is fixedly connected to the inner ring side wall of the steel ring, one side of the steel ring extends outward to have a limiting ring edge, the inner wall of the second pipe near one end of the first pipe is recessed inward to form a groove, the groove is adapted to the outer diameter of the steel ring for accommodating the steel ring, and the bottom of the groove is provided with an annular groove adapted to the limiting ring edge.

[0006] The connecting components for monitoring lumbrokinase freeze-drying, by providing a filter within the vacuum line, prevent impurities from being drawn into the freeze-drying mass spectrometer and causing instrument malfunction or damage. Furthermore, the filter is positioned between the first and second pipes to facilitate removal and replacement of the filter. Furthermore, by providing corresponding connections between the two pipes, the mixing of clamps is avoided. Furthermore, since lumbrokinase freeze-drying is performed by extracting air from the drying oven via a condenser, the freeze-drying mass spectrometer monitors the air being extracted from the drying oven, requiring the extraction force to be greater than the extraction force of the condenser. The better the sealing properties of the pipe, the less force required for vacuum extraction. Therefore, by providing a groove and a retaining ring that cooperate with each other to achieve a metal seal between the two, the sealing effect is better than that achieved by sealing the clamp and the metal bellows with a rubber seal. This makes extraction and monitoring easier for the freeze-drying mass spectrometer, resulting in higher monitoring efficiency. The first and second pipes are connected by threads, preventing them from loosening and resulting in poor sealing. This, in turn, prevents impurities from the outside air from being drawn into the freeze-drying mass spectrometer, affecting the monitor's detection accuracy. Therefore, the present invention solves the problem of the prior art lacking a highly sealed connection component for lumbrokinase freeze-drying monitoring that prevents impurities from entering the freeze-drying mass spectrometer.

[0007] In addition, the connecting component for monitoring lyophilization of lumbrokinase according to the present invention may also have the following additional technical features:

[0008] Preferably, the first pipe is fixedly connected to one end thereof close to the second pipe with a threaded seat, the inner side of the threaded seat is provided with an internal thread, and the outer side of the second pipe is provided with an external thread adapted to the internal thread.

[0009] Preferably, the top of the first pipe near one end of the second pipe is recessed inward to form an annular limiting groove, and the end of the steel ring away from the limiting ring edge extends outward to form a limiting boss adapted to the annular limiting groove.

[0010] Preferably, an annular elastic member is provided in the annular limiting groove, and the sum of the volumes of the annular elastic member and the limiting boss is greater than the volume of the annular limiting groove.

[0011] Preferably, a sealing groove is provided on the outer side of the limiting boss, and a sealing ring is provided in the sealing groove.

[0012] Preferably, the inner ring diameter of the steel ring, the inner diameter of the first pipe and the inner diameter of the second pipe are all the same.

[0013] Preferably, the monitoring device further comprises a valve, and the valve is arranged on the first pipeline.

[0014] Preferably, the first pipe and the second pipe are both provided with anti-slip components at one end close to each other.

[0015] Preferably, the protective component on the first pipe is an anti-slip groove, and the anti-slip component on the second pipe is an anti-slip rib.

[0016] Preferably, a transition arc is provided at the connection between the steel ring and the limiting boss. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 This is a schematic diagram of the structure of the assembled connecting components for monitoring lyophilization of lumbrokinase proposed in one embodiment of the present invention;

[0018] Figure 2 This is an exploded view of the connection components for monitoring lyophilization of lumbrokinase, as proposed in one embodiment of the present invention, with the vacuum assembly, detection assembly, and filter hidden behind them;

[0019] Figure 3 This is a partial cross-sectional view of the connection component for monitoring lumbrokinase freeze-drying according to one embodiment of the present invention, after the vacuum assembly and the detection assembly are hidden;

[0020] Figure 4 This is a structural diagram of the first pipeline proposed in one embodiment of the present utility model;

[0021] Figure 5 This is a schematic structural diagram of a second pipeline proposed in one embodiment of the present utility model;

[0022] Figure 6 This is a schematic structural diagram of a steel ring proposed in one embodiment of the present utility model;

[0023] Figure 7 for Figure 6 Structural diagram from another perspective;

[0024] Description of main component symbols:

[0025] Vacuum pipeline 10 First pipeline 11 Second pipeline 12 Filters 20 steel rims 21 filter 22 Limiting ring edge 211 groove 121 Annular groove 122 Threaded seat 30 Annular limit groove 111 Limiting boss 212 Ring elastic member 40 sealing groove 213 sealing ring 50 Anti-slip parts 60 Monitoring device 70 drying oven 80

[0026] The following specific embodiments will further illustrate the present invention in conjunction with the above-mentioned drawings. DETAILED DESCRIPTION

[0027] To facilitate understanding of the present invention, a more comprehensive description of the present invention will be provided below with reference to the accompanying drawings. The drawings illustrate several embodiments of the present invention. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided to provide a more thorough and comprehensive understanding of the present invention.

[0028] It should be noted that when an element is referred to as being "fixed to" another element, it may be directly on the other element or there may be an intermediate element. When an element is referred to as being "connected to" another element, it may be directly connected to the other element or there may be an intermediate element. The terms "vertical," "horizontal," "left," "right," and similar expressions used herein are for illustrative purposes only.

[0029] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which this invention pertains. The terms used herein in the specification of this invention are intended only to describe specific embodiments and are not intended to limit the invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0030] See also Figures 1 to 7 , shown is a connecting component for monitoring lyophilization of lumbrokinase in an embodiment of the present invention, including a vacuum line 10 for connecting a drying oven 80 and a monitoring device 70, wherein:

[0031] The vacuum pipeline 10 includes a first pipe 11 at one end for connecting to the drying box 80, and a second pipe 12 with one end connected to the first pipe 11 and the other end connected to the monitoring device 70. A filter element 20 is provided between the first pipe 11 and the second pipe 12. The filter element 20 includes a steel ring 21 and a filter screen 22 arranged on the steel ring 21. The outer side of the filter screen 22 is fixedly connected to the inner ring side wall of the steel ring 21. One side of the steel ring 21 extends outward with a limiting ring edge 211. The inner wall of the second pipe 12 near one end of the first pipe 11 is recessed inward to form a groove 121. The groove 121 is adapted to the outer diameter of the steel ring 21 for accommodating the steel ring 21. The bottom of the groove 121 is provided with an annular groove 122 adapted to the limiting ring edge 211.

[0032] As can be understood, by providing a filter 20 within the vacuum line 10, impurities are prevented from being drawn into the freeze-drying mass spectrometer and causing instrument malfunction or damage. Furthermore, the filter 20 is disposed between the first pipe 11 and the second pipe 12 to facilitate removal and replacement of the filter 20. Furthermore, by providing corresponding connections between the two pipes, the mixing of clamps is avoided. Furthermore, since the lumbrokinase is freeze-dried by extracting air from the drying oven 80 for condensation via a condensing device, the freeze-drying mass spectrometer monitors the air extracted from the drying oven 80 for monitoring, requiring the extraction force to be greater than the extraction force of the condensing device. The better the sealing performance of the pipe, the less force required for vacuum extraction. Therefore, by providing a metal seal between the groove 121 and the limiting ring edge 211, a better sealing effect is achieved compared to sealing between the clamp and the metal bellows via a rubber sealing ring. This makes extraction and monitoring easier for the freeze-drying mass spectrometer, resulting in higher monitoring efficiency. Furthermore, the first pipe 11 and the second pipe 12 are connected by a thread, preventing them from becoming loose and resulting in poor sealing. This, in turn, prevents impurities from the outside air from being drawn into the freeze-drying mass spectrometer, affecting the monitor's detection accuracy. Therefore, the present invention solves the problem of the prior art lacking a highly sealed connection component for lumbrokinase freeze-drying monitoring that prevents impurities from entering the freeze-drying mass spectrometer.

[0033] In practice, the filter element 20 is secured within the second pipe 12 by providing a groove 121 that cooperates with the steel ring 21. The filter element 20 is then secured again by the retaining ring 211 that cooperates with the annular groove 122, securing the steel ring 21 in place and concentric with the second pipe 12. Furthermore, the retaining ring 211 and the annular groove 122 form an interference fit to ensure a secure connection, and the retaining ring 211 has a certain degree of elasticity to facilitate assembly and disassembly of the filter element 20. Furthermore, the pores on the filter screen 22 are uniformly sized and evenly distributed, ensuring consistent and parallel airflow after passing through the filter screen 22. This prevents turbulence that would require greater suction force for vacuuming, thereby improving detection efficiency.

[0034] Furthermore, a threaded seat 30 is securely mounted on the end of the first pipe 11 near the second pipe 12. The inner side of the threaded seat 30 has internal threads, and the outer side of the second pipe 12 near the first pipe 11 has external threads that mate with the internal threads. By providing the threaded seat 30 and mating the internal threads inside the threaded seat 30 with the external threads outside the second pipe 12, the first and second pipes 11, 12 are aligned and securely connected. Furthermore, this threaded mating facilitates disassembly between the first and second pipes 11, 12, and facilitates replacement of the filter element 20, avoiding the time-consuming and labor-intensive disassembly and assembly that could compromise overall efficiency.

[0035] In addition, the top of the first pipe 11 near one end of the second pipe 12 is recessed inward to form an annular limiting groove 111, and a limiting boss 212 is extended outward from the end of the steel ring 21 away from the limiting ring edge 211, which is adapted to the annular limiting groove 111. By providing the annular limiting groove 111 and the limiting boss 212 to cooperate with each other, the steel ring 21 and the first pipe 11 are fixedly connected to each other. In addition, since the positioning effect of the threaded connection is poor, the cooperation between the annular limiting groove 111 and the limiting boss 212 can also achieve a positioning effect, thereby ensuring that the second pipe 12, the filter element 20 and the first pipe 11 are all concentrically arranged, thereby making the air flow in the vacuum pipeline 10 smoother, thereby reducing the difficulty of air extraction by the monitoring device and improving detection efficiency.

[0036] By way of example and not limitation, in some optional embodiments, an annular elastic member 40 is disposed within the annular limiting groove 111, and the combined volume of the annular elastic member 40 and the limiting boss 212 is greater than the volume of the annular limiting groove 111. By disposing the annular elastic member 40 within the annular limiting groove 111, and ensuring that the combined volume of the annular elastic member 40 and the limiting boss 212 is greater than that of the annular limiting groove 111, the limiting boss 212 compresses the annular elastic member 40 during assembly of the vacuum pumping pipeline 10, thereby ensuring a seal at the connection between the first pipe 11 and the steel ring 21. Furthermore, the interference fit between the limiting ring edge 211 and the annular groove 122, coupled with the elasticity of the limiting ring edge 211, achieves a rigid seal between the second pipe 12 and the steel ring 21. This ensures the sealing of the vacuum pumping pipeline 10, reduces the difficulty of vacuuming the monitoring device, and improves detection efficiency.

[0037] Specifically, a sealing groove 213 is provided on the outside of the limiting boss 212, and a sealing ring 50 is provided in the sealing groove 213. Since the sealing effect of the elastic seal between the first pipe 11 and the steel ring 21 is slightly worse than the metal seal between the second pipe 12 and the steel ring 21, a secondary sealing effect between the steel ring 21 and the first pipe 11 is achieved by providing a sealing groove 213 on the outside of the limiting boss 212 and providing a sealing ring 50 in the sealing groove 213. In addition, since the sealing ring 50 is provided on the outside of the limiting boss 212, when the first pipe 11 and the second pipe 12 are separated, the sealing ring 50 can be directly removed for easy replacement. In addition, when the filter element 20 needs to be replaced, the sealing ring 50 can be removed and the sealing groove 213 can be used to assist in the disassembly of the filter element 20, thereby making it easy to disassemble and assemble the filter element 20, avoiding the trouble of disassembly and assembly taking too long, thereby affecting the detection effect of the freeze-drying effect.

[0038] In addition, the inner diameter of the steel ring 21, the inner diameter of the first pipe 11 and the inner diameter of the second pipe 12 are all the same. The same inner diameter of the three makes the interior of the vacuum pipe 10 smooth, thereby reducing the difficulty of vacuuming the monitoring device and improving detection efficiency.

[0039] Specifically, the monitoring device also includes a valve disposed on the first conduit 11. This valve isolates the drying chamber 80 from the monitoring device when the filter element 20 is replaced, thereby preventing any impact on the freeze-drying of the lumbrokinase and ensuring efficient freeze-drying. Furthermore, the valve is only opened when the monitoring device is activated to prevent interference with the condensation unit's suction and condensation operations, thereby ensuring the freeze-drying efficiency of the lumbrokinase.

[0040] Additionally, anti-slip components 60 are provided on the adjacent ends of the first and second pipes 11, 12. The provision of anti-slip components 60 facilitates assembly and disassembly of the first and second pipes 11, 12. By way of example and not limitation, in some optional embodiments, the threaded seat 30 of the first pipe 11 is provided with anti-slip grooves, and the outer side of the second pipe 12 is provided with polygonal anti-slip ribs to facilitate assembly and disassembly, avoiding time-consuming and inefficient disassembly.

[0041] Specifically, a transition arc is provided at the connection between the steel ring 21 and the limiting boss 212. Because the limiting boss 212 must constantly withstand the extrusion force of the annular elastic member 40, and the steel ring 21 and limiting boss 212 are offset and relatively weak, the provision of a transition arc strengthens the connection between the limiting boss 212 and the steel ring 21, preventing breakage between the limiting boss 212 and the steel ring 21. Furthermore, curved surfaces that align with the transition arc are provided on both the first and second pipes 11 and 12 to ensure a tight seal between the pipes and the steel ring 21.

[0042] In summary, by providing a filter element 20 in the vacuum line 10, impurities are prevented from being drawn into the freeze-drying mass spectrometer and causing instrument failure or damage. In addition, the filter element 20 is provided between the first pipe 11 and the second pipe 12 to facilitate the removal and replacement of the filter element 20. In addition, by providing a corresponding connection between the two pipes, the situation of mixing clamps is avoided. In addition, since the air in the drying box 80 is condensed by the condensing device when the lumbrokinase is freeze-dried, the air in the drying box 80 is extracted for monitoring by the freeze-drying mass spectrometer, and the extraction force needs to be greater than the extraction force of the condensing device. The better the sealing of the pipeline, the smaller the force required for vacuum extraction. Therefore, by providing a groove 121 and a limiting ring edge 211 to cooperate with each other, a metal seal between the two is achieved. Compared with the sealing between the clamp and the metal bellows through a rubber sealing ring, the sealing effect is better. As a result, the freeze-drying mass spectrometer is easier to extract and monitor, making the monitoring efficiency higher. Furthermore, the first pipe 11 and the second pipe 12 are connected by a thread, preventing them from becoming loose and resulting in poor sealing. This, in turn, prevents impurities from the outside air from being drawn into the freeze-drying mass spectrometer, affecting the monitor's detection accuracy. Therefore, the present invention solves the problem of the prior art lacking a highly sealed connection component for lumbrokinase freeze-drying monitoring that prevents impurities from entering the freeze-drying mass spectrometer.

[0043] Throughout this specification, reference to terms such as "one embodiment," "some embodiments," "examples," "specific examples," or "some examples" means that the specific features, structures, materials, or characteristics described in conjunction with that embodiment or example are included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

[0044] The above-described embodiments merely represent several implementation methods of the present invention. While the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the present invention. It should be noted that a person skilled in the art would be able to make various modifications and improvements without departing from the concept of the present invention, and these modifications and improvements fall within the scope of protection of the present invention. Therefore, the scope of protection of the present invention shall be determined by the appended claims.

Claims

1. A connecting component for monitoring lyophilization of lumbrokinase, characterized in that: It includes a vacuum pipeline for connecting a drying box and a monitoring device, the vacuum pipeline includes a first pipe at one end for connecting to the drying box, and a second pipe at one end connected to the first pipe and the other end connected to the monitoring device, a filter is provided between the first pipe and the second pipe, the filter includes a steel ring and a filter screen arranged on the steel ring, the outer side of the filter screen is fixedly connected to the inner ring side wall of the steel ring, one side of the steel ring extends outward to have a limiting ring edge, the inner wall of the second pipe near one end of the first pipe is recessed inward to form a groove, the groove is adapted to the outer diameter of the steel ring for accommodating the steel ring, and the bottom of the groove is provided with an annular groove adapted to the limiting ring edge.

2. The connecting component for monitoring lyophilization of lumbrokinase according to claim 1, characterized in that: The first pipe is provided with a threaded seat fixedly connected to one end thereof close to the second pipe, and an internal thread is provided on the inner side of the threaded seat. The second pipe is provided with an external thread matching the internal thread on the outer side thereof close to one end thereof.

3. The connecting component for monitoring lyophilization of lumbrokinase according to claim 2, characterized in that: The top of the first pipe near one end of the second pipe is recessed inward to form an annular limiting groove, and the end of the steel ring away from the limiting ring edge extends outward to form a limiting boss adapted to the annular limiting groove.

4. The connecting component for monitoring lumbrokinase freeze-drying according to claim 3, characterized in that: An annular elastic member is provided in the annular limiting groove, and the sum of the volumes of the annular elastic member and the limiting boss is greater than the volume of the annular limiting groove.

5. The connecting component for monitoring lyophilization of lumbrokinase according to claim 1, characterized in that: A sealing groove is provided on the outer side of the limiting boss, and a sealing ring is provided in the sealing groove.

6. The connecting component for monitoring lumbrokinase freeze-drying according to claim 2, characterized in that: The inner ring diameter of the steel ring, the inner diameter of the first pipe and the inner diameter of the second pipe are all the same.

7. The connecting component for monitoring lyophilization of lumbrokinase according to claim 1, characterized in that: The first pipeline is also provided with a valve.

8. The connecting component for monitoring lumbrokinase freeze-drying according to claim 1, characterized in that: The first pipe and the second pipe are both provided with anti-slip components at one end close to each other.

9. The connecting component for monitoring lumbrokinase freeze-drying according to claim 8, characterized in that: The protective component on the first pipe is an anti-slip groove, and the anti-slip component on the second pipe is an anti-slip rib.

10. The connecting component for monitoring lyophilization of lumbrokinase according to claim 3, characterized in that: A transition arc is provided at the connection between the steel ring and the limiting boss.

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