Micro-bubbling reaction system in field of synthesis

Abstract

The utility model discloses a microbubble reaction system in the field of synthesis, which comprises a microreactor, a reaction liquid circulating pump and a raw material liquid circulating kettle, the lower part of one side of the microreactor is provided with a reaction liquid inlet, the upper part of the other side of the microreactor is provided with a reaction liquid outlet, and the reaction liquid circulating pump is connected with the reaction liquid inlet through a pipeline; the reaction liquid outlet is connected with the raw material liquid circulating kettle through a pipeline, the microreactor comprises a reaction area, a second refrigerant jacket is arranged on the inner layer of the reaction area, light-transmitting glass is arranged on the inner layer of the second refrigerant jacket, a UV lamp cavity is formed in the inner layer of the light-transmitting glass, a UV light source is arranged in the UV lamp cavity, a first stainless steel refrigerant jacket is arranged on the outer layer of the reaction area, and a second stainless steel refrigerant jacket is arranged on the inner layer of the first stainless steel refrigerant jacket. The system disclosed by the utility model has the advantages of high heat and mass transfer efficiency, accurate and controllable reaction temperature and material retention time and the like.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the technical field of pharmaceutical chemical production device, specifically relates to a microbubble reaction system in synthetic field. BACKGROUND

[0002] In chemical industry, the mixing of two fluids is a common mass transfer process, and the commonly used reaction equipment includes mixing kettle, extraction tower and static mixer, which can meet the needs of large-scale production due to large processing capacity; however, in general, these mixing equipment provides macro-scale mixing for fluids, and has the disadvantages of low mixing efficiency, large power consumption and large equipment volume.

[0003] At present, photochemical reaction devices usually adopt two types of ways: (1) reaction kettle - batch synthesis; (2) continuous reaction device, such as falling film reactor and coil reactor.

[0004] The conventional reaction kettle device generally comprises a reaction kettle provided with heat exchange coil or jacket, a quartz glass lampshade installed in the kettle cavity, and a visible light or ultraviolet light source installed in the lampshade. The device is generally a batch reaction, that is, all substrates are reacted with the light source in the kettle within a certain time period. The defects are: (1) large amount of hazardous substances, which is easy to cause local concentration, material flushing and even burning and explosion; (2) a large amount of heat generated by strong exothermic chemical reaction cannot be discharged in time, which is easy to cause "flying temperature" phenomenon; and the above defects will become more and more obvious with the increase of the volume of the reaction kettle. The product content obtained by using the kettle type equipment is low, the yield is poor, the product quality is unstable, and the production expansion is limited.

[0005] Therefore, the utility model provides a microbubble reaction system in synthetic field which is high in safety and easy to operate. UTILITY MODEL CONTENT

[0006] In view of the problems in the prior art, the utility model aims to provide a microbubble reaction system in synthetic field, which has the characteristics of high heat and mass transfer efficiency, and accurate controllable reaction temperature and material residence time.

[0007] The technical scheme of the utility model is as follows:

[0008] The micro-bubbling reaction system in the synthetic field comprises a micro-reactor, a reaction liquid circulating pump and a raw material liquid circulating kettle, one side of the lower part of the micro-reactor is provided with a reaction liquid inlet, and the other side of the upper part of the micro-reactor is provided with a reaction liquid outlet, the reaction liquid circulating pump is connected with the reaction liquid inlet through a pipeline, and the reaction liquid outlet is connected with the raw material liquid circulating kettle through a pipeline, the micro-reactor comprises a reaction zone, the inner layer of the reaction zone is provided with a refrigerant jacket two, the inner layer of the refrigerant jacket two is provided with a light-transmitting glass, the inner layer of the light-transmitting glass is provided with a UV lamp cavity, the UV lamp cavity is provided with a UV light source, and the outer layer of the reaction zone is provided with a stainless steel refrigerant jacket one.

[0009] Further, the refrigerant jacket two is provided with a refrigerant two inlet close to one side of the lower end of the micro-reactor, and is provided with a refrigerant two outlet close to the other side of the upper end of the micro-reactor.

[0010] Further, the refrigerant in the refrigerant jacket two is deionized water, and a refrigerant two outlet thermometer is arranged on the refrigerant two outlet pipeline.

[0011] Further, the refrigerant jacket two is provided with a refrigerant two inlet close to one side of the lower end of the micro-reactor, and is provided with a refrigerant two outlet close to the other side of the upper end of the micro-reactor.

[0012] Further, the refrigerant in the refrigerant jacket two is deionized water, and a refrigerant two outlet thermometer is arranged on the refrigerant two outlet pipeline.

[0013] Further, the micro-reactor is provided with a nitrogen inlet at the lower end and is provided with a vent at the upper end, and the nitrogen inlet penetrates through the UV lamp cavity and the vent.

[0014] Further, a nitrogen flow meter is arranged on the pipeline of the nitrogen inlet.

[0015] Further, a reaction liquid outlet thermometer is arranged on the pipeline connected between the reaction liquid outlet and the raw material liquid circulating kettle.

[0016] Further, the light-transmitting glass adopts quartz glass, and the thickness of the light-transmitting glass is 7-10 mm.

[0017] Compared with the prior art, the beneficial effects of the micro-bubbling reaction system are as follows:

[0018] 1) The geometric size of the fluid channel of the system is micron level, and the retention amount of dangerous substances is small; the mass transfer and heat transfer efficiency of the micro-channel is high, a large amount of heat generated by a strong exothermic chemical reaction can be quickly led away, and the "flying temperature" phenomenon is avoided; the microstructure improves the explosion-proof performance of the device, the device can be designed according to the type of the system, the local concentration is prevented from being too large, the flying temperature, the material is prevented from being rushed, and even the safety problems such as burning and explosion are avoided, even if small-range burning or explosion occurs, the zero harm to the operator can be ensured, and continuous flow intrinsic safety production is realized;

[0019] 2) The system of this utility model increases the number of channels, that is, adopts a multi-channel parallel mode of amplification. The reaction conditions of each channel are the same, thereby greatly shortening the product development cycle. Based on the amplification mode and continuous production process of this system, the number of units can be flexibly increased or decreased in actual production to adjust the production scale to meet market demand and adapt to the ever-changing market;

[0020] 3) The system of this utility model has the advantages of high heat and mass transfer efficiency, precise control of reaction temperature and material residence time, etc., which can improve the purity of the target product, increase product yield and selectivity, reduce the total production cost, reduce the emission of "three wastes", and thus reduce the cost of "three wastes" treatment;

[0021] 4) The utility model realizes the process of photochemical reaction while transporting the reaction liquid by irradiating UV light into the transparent reactor during the flow of the reaction liquid in the reaction zone; the pressure in the reaction zone is controlled by controlling the outlet pressure of the reaction liquid circulation pump; the utilization rate of the light source is improved by designing the thickness of the transparent glass, and the cost and energy consumption of the LED light source are greatly reduced, thereby realizing industrial scale-up and mass production. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 This is a schematic diagram of the overall structure of the utility model system.

[0023] In the figure: 1. Microreactor; 11. Raw material liquid circulation kettle; 2. Reaction zone; 21. UV lamp cavity; 3. Translucent glass; 4. Reaction liquid inlet; 5. Reaction liquid outlet; 51. Reaction liquid outlet thermometer; 6. Nitrogen inlet; 61. Nitrogen flowmeter; 7. Vent; 8. Stainless steel refrigerant jacket 1; 81. Refrigerant inlet 1; 82. Refrigerant outlet 1; 9. Refrigerant jacket 2; 91. Refrigerant inlet 2; 92. Refrigerant outlet 2; 93. Refrigerant outlet thermometer 2; 10. Reaction liquid circulation pump; 11. Raw material liquid circulation kettle; 12. UV light source. DETAILED DESCRIPTION

[0024] The present invention will be further described below in conjunction with the accompanying drawings, but the scope of protection of the present invention is not limited to the described scope.

[0025] like Figure 1 As shown, a microbubble reaction system in the field of synthesis includes a microreactor 1, a reaction liquid circulation pump 10 and a raw material liquid circulation kettle 11. A reaction liquid inlet 4 is provided at the lower part of one side of the microreactor 1, and a reaction liquid outlet 5 is provided at the upper part of the other side. The reaction liquid circulation pump 10 is connected to the reaction liquid inlet 4 through a pipeline, and the reaction liquid outlet 5 is connected to the raw material liquid circulation kettle 11 through a pipeline.

[0026] The micro reactor 1 comprises a reaction zone 2, the reaction zone 2 is internally provided with a refrigerant jacket two 9, the refrigerant jacket two 9 is internally provided with a light-transmitting glass 3, the light-transmitting glass 3 is internally provided with a UV lamp cavity 21, and the UV lamp cavity 21 is internally provided with a UV light source 12 for irradiating ultraviolet light to the reaction zone 2.

[0027] During the flowing of the reaction liquid in the reaction zone 2, the reaction liquid is reacted by the UV light source 12 irradiating into the light-transmitting reaction zone 2, so that the process of photochemical reaction during conveying is realized.

[0028] The refrigerant jacket two 9 is provided with a refrigerant two inlet 91 on one side close to the lower end of the micro reactor 1, and is provided with a refrigerant two outlet 92 on the other side close to the upper end of the micro reactor 1.

[0029] In the embodiment, the refrigerant in the refrigerant jacket two 9 is deionized water.

[0030] The refrigerant two outlet 92 is provided with a refrigerant two outlet thermometer 93 on the pipeline, so as to monitor the cooling condition in real time.

[0031] The stainless steel refrigerant jacket one 8 is provided with a refrigerant one inlet 81 on one side close to the lower end of the micro reactor 1, and is provided with a refrigerant one outlet 82 on the other side close to the upper end of the micro reactor 1.

[0032] In the embodiment, the refrigerant in the stainless steel refrigerant jacket one 8 is 7° water.

[0033] The micro reactor 1 is provided with a nitrogen inlet 6 at the lower end, and is provided with a vent 7 at the upper end, the nitrogen inlet 6 is communicated with the UV lamp cavity 21 and the vent 7, and nitrogen is continuously introduced during the reaction to take away the heat generated by the UV light source 12.

[0034] The pipeline of the nitrogen inlet 6 is provided with a nitrogen flowmeter 61 for controlling the flow of nitrogen.

[0035] In the embodiment, the pipeline connected between the reaction liquid outlet 5 and the raw material liquid circulating kettle 11 is provided with a reaction liquid outlet thermometer 51.

[0036] The system of the utility model relates to the use of the UV light source 12 and nitrogen, and in industrial production, a separate room needs to be separately arranged, an exhaust fan, a combustible and oxygen content alarm device are arranged in the room, and the safety of personnel is ensured.

[0037] The light-transmitting glass 3 adopts a corrosion-resistant material, preferably quartz glass, meanwhile, the outlet pressure of the reaction liquid circulating pump 10 is controlled to be below 2 atm, so that the more harsh reaction conditions in industrialization are adapted, the stable operation of the device is realized, and the flowing and sufficient reaction of the reaction liquid are not affected. The thickness of the light-transmitting glass 3 is preferably 7-10 mm. In this way, the operation stability of the reaction device is ensured, and the utilization rate of the light source is improved.

[0038] In the embodiment, the system can operate in parallel mode amplification, and theoretically, there is no amplification effect, each reaction condition is the same, and industrial scale production is realized.

Claims

1. A microbubble reaction system in the field of synthesis, comprising a microreactor (1), a reaction liquid circulation pump (10) and a raw material liquid circulation kettle (11), wherein a reaction liquid inlet (4) is provided at the lower portion of one side of the microreactor (1), and a reaction liquid outlet (5) is provided at the upper portion of the other side thereof, the reaction liquid circulation pump (10) is connected to the reaction liquid inlet (4) via a pipeline, and the reaction liquid outlet (5) is connected to the raw material liquid circulation kettle (11) via a pipeline, characterized in that The microreactor (1) includes a reaction zone (2), the inner layer of the reaction zone (2) is provided with a second refrigerant jacket (9), the inner layer of the second refrigerant jacket (9) is provided with a light-transmitting glass (3), the inner layer of the light-transmitting glass (3) is provided with a UV lamp cavity (21), the UV lamp cavity (21) is provided with a UV light source (12), and the outer layer of the reaction zone (2) is provided with a stainless steel refrigerant jacket (8).

2. The microbubble reaction system according to claim 1, characterized in that A second refrigerant inlet (91) is provided on one side of the refrigerant jacket (9) close to the lower end of the microreactor (1), and a second refrigerant outlet (92) is provided on the other side of the refrigerant jacket (9) close to the upper end of the microreactor (1).

3. The microbubble reaction system of a synthesis field according to claim 2, characterized in that The refrigerant in the refrigerant jacket 2 (9) is deionized water; a refrigerant outlet 2 thermometer (93) is provided on the refrigerant outlet 2 (92) pipe.

4. The microbubble reaction system in the field of synthesis according to claim 1, characterized in that A refrigerant inlet (81) is provided on one side of the stainless steel refrigerant jacket (8) close to the lower end of the microreactor (1), and a refrigerant outlet (82) is provided on the other side of the stainless steel refrigerant jacket (8) close to the upper end of the microreactor (1).

5. The microbubble reaction system according to claim 1 or 4, characterized in that The refrigerant in the stainless steel refrigerant jacket (8) is 7° water.

6. The microbubble reaction system in the field of synthesis according to claim 1, characterized in that The microreactor (1) is provided with a nitrogen inlet (6) at its lower end and a vent (7) at its upper end, wherein the nitrogen inlet (6) is in communication with the UV lamp cavity (21) and the vent (7).

7. The microbubble reaction system for the synthesis field according to claim 6, characterized in that A nitrogen flow meter (61) is provided on the pipeline of the nitrogen inlet (6).

8. The microbubble reaction system in the field of synthesis according to claim 1, characterized in that A reaction liquid outlet thermometer (51) is provided on the pipeline connecting the reaction liquid outlet (5) and the raw material liquid circulation kettle (11).

9. The microbubble reaction system in the field of synthesis according to claim 1, characterized in that The light-transmitting glass (3) is made of quartz glass, and the thickness of the light-transmitting glass (3) is 7-10 mm.

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