Endotoxin detection kit

Abstract

The utility model discloses an endotoxin detection kit, which relates to the field of biological detection kits, and comprises a detection kit, the top of the inner side of the detection kit is provided with a support frame, the top end of the support frame is uniformly provided with a plurality of clamping holes, and the inner side of each clamping hole is provided with a taking and sending assembly matched with the detection kit. Protective top covers are arranged at the top ends of the taking and sending assemblies; a kit cover matched with the supporting frame is arranged on one side of the top end of the detection kit. Under the matching action of the detection kit, the supporting frame, the clamping hole and the taking and conveying assembly, bacterial endotoxin in a biological product can be effectively detected and quantified, the quality and safety of the product are ensured, serious adverse reactions caused by the endotoxin are prevented, and the health of a patient is guaranteed; and meanwhile, the detection efficiency can be improved, the standardization degree of a laboratory working process is improved, and the method has important significance on pharmaceutical, medical and biological product industries.

Description

TECHNICAL FIELD

[0001] The utility model relates to biological detection box, specifically, relate to a endotoxin detection kit. BACKGROUND

[0002] Endotoxin detection kit is a kind of detection tool for detecting whether the bacteria endotoxin (lipopolysaccharide) in blood, drug or other biological products exists. It is usually based on limulus reagent detection technology, and can quantitatively or qualitatively determine the content of endotoxin in vitro by specific chemical reaction, which is of great significance to ensure the safety of biological products, meet the regulatory requirements and prevent serious adverse reactions caused by endotoxin.

[0003] During the use of endotoxin detection kit, ampoule is often used as the container for storing and transporting endotoxin detection kit. Because ampoule has good sealing property and chemical resistance, it can protect the reagents in the kit from external pollution and factors such as light and heat, ensure the stability of reagents and the accuracy of detection results, and thus plays an important role in endotoxin detection.

[0004] For example, Chinese patent number CN221252184U discloses an endotoxin detection kit, which comprises a box body, a storage rack, a placing groove, a locking assembly, a box cover, a fixing block, a rotating ball, a pull rope and a limiting rod. In the detection kit, the storage rack can be pulled upward when the box cover is opened, so that the storage rack carrying the ampoule moves upward, and the ampoule can be better taken.

[0005] However, during the use of the detection kit, it is difficult to avoid the knocking of other ampoules in the detection kit when the ampoule is taken out and put in for many times, which may cause the ampoule to break. The breakage of ampoule in endotoxin detection kit may cause reagent contamination, invalidation, cross contamination, increase operation risk and economic loss, and affect the accuracy of detection and the safety of laboratory.

[0006] At present, there is no effective solution to the problems in the related art. UTILITY MODEL CONTENT

[0007] In view of the problems in the related art, the utility model provides an endotoxin detection kit to overcome the above technical problems existing in the prior art.

[0008] Therefore, the utility model adopts the following specific technical solutions:

[0009] The utility model provides an endotoxin detection kit, including detection kit, the inside top of detection kit is provided with support frame, the top of support frame is evenly provided with a plurality of clamping holes, the inside of clamping hole is provided with with taking and sending subassembly that cooperates with detection kit, the top of taking and sending subassembly is provided with protective top cap, the top of detection kit one side is provided with reagent box cover that cooperates with support frame.

[0010] Further, in order to guarantee the stability of endotoxin ampoule during taking and placing, the clamping hole comprises a through hole formed in the top of the support frame, the bottom of the support frame is provided with an annular groove matched with the through hole, the inner top of the annular groove is uniformly provided with four groups of arc-shaped limiters, the arc-shaped limiters and the support frame have a gap, and the gap is left between the adjacent two groups of arc-shaped limiters; the arc-shaped limiters comprise arc-shaped limit blocks one symmetrically arranged at the inner top of the annular groove, the bottom of the two groups of arc-shaped limit blocks one is provided with arc-shaped inclined surfaces one in the same direction, and the two groups of arc-shaped limit blocks one are provided with limit inclined blocks matched with the arc-shaped inclined surfaces one, and the limit inclined blocks are provided with limit grooves matched with the through hole on one side.

[0011] Further, in order to avoid the collision of endotoxin ampoule during taking and placing, the taking and sending subassembly comprises a hollow cylindrical frame one arranged on the inner side of the through hole and matched with the protective top cap, the bottom of the hollow cylindrical frame one is arc-shaped sawtooth, and arc-shaped inclined surfaces two are formed on both sides of each sawtooth in the arc-shaped sawtooth; the outer side of the hollow cylindrical frame one is uniformly provided with a plurality of limit protrusions matched with the limit grooves, and the center surfaces of the plurality of limit protrusions are respectively parallel to the center surfaces of each sawtooth in the arc-shaped sawtooth; the inside of the hollow cylindrical frame one is provided with a clamping piece, and the bottom of the clamping piece is provided with a spring piece; the clamping piece comprises a hollow cylindrical frame two arranged in the inside of the hollow cylindrical frame one, the outer bottom of the hollow cylindrical frame two is provided with an annular block, the outer side of the annular block is uniformly provided with four groups of arc-shaped limit blocks two matched with the hollow cylindrical frame two, the top of the arc-shaped limit blocks two is provided with arc-shaped inclined surfaces three matched with the arc-shaped inclined surfaces one and the arc-shaped inclined surfaces two; the inner bottom of the hollow cylindrical frame two is provided with a limit plate matched with the spring piece; the spring piece comprises a spring arranged at the bottom of the hollow cylindrical frame two, and the bottom of the spring is provided with a fixing seat matched with the hollow cylindrical frame two and the detection kit.

[0012] Further, in order to improve the convenience of using the detection kit, the detection kit and the reagent box cover are connected through a hinge; the outer side of the protective top cap is provided with anti-skid lines.

[0013] The utility model discloses an endotoxin detection kit, including detection kit, the inside top of detection kit is provided with support frame, the top of support frame is evenly provided with a plurality of clamping holes, the inside of clamping hole is provided with with taking and sending subassembly that cooperates with detection kit, the top of taking and sending subassembly is provided with protective top cap, the top of detection kit one side is provided with reagent box cover that cooperates with support frame.

[0014] 1. The utility model discloses a detection kit, support frame, the cooperation of joint hole and fetches and send subassembly under, can effectively detect and quantitative biological product in bacterial endotoxin, ensures product quality and safety, prevents the serious adverse reaction caused by endotoxin, has guaranteed the health of patient, help to improve detection efficiency, improved the standardization degree of laboratory work process, has the important significance to pharmaceutical, medical and biological product industry.

[0015] 2. The utility model discloses the cooperation of joint hole, fetches and send subassembly and protective top cover under, can avoid the situation that the other ampoule bottle in detection kit is knocked when fetching and putting endotoxin ampoule bottle for many times in the process of using detection kit, reduced the operation risk, reduced the cost loss, and improved the accuracy of detection and the safety of laboratory. BRIEF DESCRIPTION OF DRAWINGS

[0016] In order to more clearly illustrate the technical scheme in the embodiment of the utility model or prior art, the following will be briefly introduced the drawing needed to be used in the embodiment, obviously, the drawing in the following description only some embodiments of the utility model, for ordinary skilled person in the art, under the premise of not paying creative labor, still can obtain other drawings according to these drawings.

[0017] Figure 1 It is the structure diagram of a kind of endotoxin detection kit according to the utility model embodiment;

[0018] Figure 2 It is the sectional view of a kind of endotoxin detection kit according to the utility model embodiment;

[0019] Figure 3 It is Figure 2 the local enlarged view of A in;

[0020] Figure 4 It is Figure 2 the local enlarged view of B in;

[0021] Figure 5 It is the three-dimensional assembly drawing of fetches and send subassembly in a kind of endotoxin detection kit according to the utility model embodiment;

[0022] Figure 6 It is Figure 5 the local enlarged view of C in.

[0023] In the drawing:

[0024] 1, detection kit; 2, support frame; 3, clamping hole; 301, through hole; 302, annular groove; 303, arc limiting piece; 3031, arc limiting block one; 3032, arc inclined surface one; 3033, limiting inclined block; 3034, limiting groove; 4, pick-and-place assembly; 401, hollow cylindrical frame one; 402, arc inclined surface two; 403, limiting protrusion; 404, clamping piece; 4041, hollow cylindrical frame two; 4042, annular block; 4043, arc limiting block two; 4044, arc inclined surface three; 4045, limiting plate; 405, spring piece; 4051, spring; 4052, fixing seat; 5, protective top cover; 6, kit cover; 7, non-slip pattern. DETAILED DESCRIPTION

[0025] To further illustrate the embodiments, the utility model provides drawings, these drawings are part of the utility model disclosure, it mainly used to illustrate the embodiment, and can cooperate with the relevant description of the specification to explain the operating principle of the embodiment, cooperate with reference to these contents, the person skilled in the art should be able to understand other possible implementation ways and the advantages of the utility model, the components in the drawing are not drawn according to scale, and similar component symbols are usually used to represent similar components.

[0026] According to the embodiments of the utility model, a kind of endotoxin detection kit is provided.

[0027] The utility model is further illustrated by combining with drawings and specific embodiments, as shown in Figures 1-6 According to the endotoxin detection kit of the embodiments of the utility model, the inside top of detection kit 1 is provided with support frame 2, the top of support frame 2 is evenly provided with several clamping holes 3, the inside of clamping hole 3 is provided with pick-and-place assembly 4 matched with detection kit 1, the top of pick-and-place assembly 4 is provided with protective top cover 5;The top side of detection kit 1 is provided with kit cover 6 matched with support frame 2;Detection kit 1 and kit cover 6 are connected by hinge;The outside of protective top cover 5 is provided with non-slip pattern 7.

[0028] With the cooperation of the test kit 1, the support frame 2, the clamping hole 3 and the taking and sending assembly 4, the bacteria endotoxin in the biological product can be effectively detected and quantified, the product quality and safety are ensured, the serious adverse reactions caused by the endotoxin are prevented, the health of the patient is ensured, meanwhile, the detection efficiency is improved, the standardization degree of the laboratory work process is improved, and the pharmaceutical, medical and biological product industries have important significance, under the cooperation of the clamping hole 3, the taking and sending assembly 4 and the protective top cover 5, when the endotoxin ampoule bottle is taken and placed for many times during the use of the test kit 1, the knocking phenomenon of other ampoule bottles in the test kit 1 is avoided, the operation risk is reduced, the cost loss is reduced, and the detection accuracy and the laboratory safety are improved.

[0029] In one embodiment, for the above-mentioned clamping hole 3, the clamping hole 3 comprises a through hole 301 opened at the top end of the support frame 2, the bottom end of the support frame 2 is provided with an annular groove 302 matched with the through hole 301, the inner top end of the annular groove 302 is uniformly provided with four groups of arc-shaped limiting pieces 303, the arc-shaped limiting pieces 303 and the support frame 2 are left with gaps, and the adjacent two groups of arc-shaped limiting pieces 303 are left with gaps; the arc-shaped limiting piece 303 comprises an arc-shaped limiting block one 3031 symmetrically arranged at the inner top end of the annular groove 302, the bottom end of the two groups of arc-shaped limiting block one 3031 is provided with arc-shaped inclined surfaces one 3032 in the same direction, the two groups of arc-shaped limiting block one 3031 are provided with limiting inclined blocks 3033 matched with the arc-shaped inclined surfaces one 3032, and the limiting inclined blocks 3033 are provided with limiting grooves 3034 matched with the through hole 301 on one side; so as to ensure the stability of the endotoxin ampoule bottle during taking and placing.

[0030] In an embodiment, for the above-mentioned taking and placing assembly 4, the taking and placing assembly 4 comprises a hollow cylindrical frame one 401 (the protective cover 5 is threadedly connected with the hollow cylindrical frame one 401) arranged inside the through hole 301 and matched with the protective cover 5, the bottom end of the hollow cylindrical frame one 401 is arc-shaped sawtooth, and both sides of each sawtooth in the arc-shaped sawtooth are formed with arc-shaped inclined surface two 402; the outer side of the hollow cylindrical frame one 401 is uniformly provided with a plurality of limiting protrusions 403 matched with the limiting grooves 3034, and the central surfaces of the plurality of limiting protrusions 403 are respectively parallel to the central surfaces of each sawtooth in the arc-shaped sawtooth; the inside of the hollow cylindrical frame one 401 is provided with a clamping piece 404, and the bottom end of the clamping piece 404 is provided with a spring piece 405; the clamping piece 404 comprises a hollow cylindrical frame two 4041 arranged inside the hollow cylindrical frame one 401, the outer bottom of the hollow cylindrical frame two 4041 is provided with an annular block 4042, the outer side of the annular block 4042 is uniformly provided with four groups of arc-shaped limiting blocks two 4043 matched with the hollow cylindrical frame two 4041, the top end of the arc-shaped limiting blocks two 4043 is provided with arc-shaped inclined surface three 4044 matched with the arc-shaped inclined surface one 3032 and the arc-shaped inclined surface two 402; the inner bottom of the hollow cylindrical frame two 4041 is provided with a limiting plate 4045 matched with the spring piece 405; the spring piece 405 comprises a spring 4051 arranged at the bottom end of the hollow cylindrical frame two 4041, and the bottom end of the spring 4051 is provided with a fixing seat 4052 matched with the hollow cylindrical frame two 4041 and the detection reagent kit 1; so as to avoid the collision of the endotoxin ampoule in the process of taking and placing.

[0031] The working principle of the taking and placing assembly 4 is as follows:

[0032] When the endotoxin ampoule placed on the top end of the limiting plate 4045 in the clamping part 404 needs to be taken out, the hollow cylindrical frame one 401 is vertically lowered along the limiting groove 3034 of the arc-shaped limiting part 303 in the clamping hole 3 by pressing the protective top cover 5, the arc-shaped inclined surface three 4044 is separated from the limiting inclined block 3033 by extrusion of the arc-shaped inclined surface two 402 on the arc-shaped inclined surface three 4044, and the hollow cylindrical frame two 4041 is extruded on the spring 4051 along the fixed seat 4052 in the spring part 405 by the arc-shaped inclined surface three 4044 and the arc-shaped inclined surface one 3032, until the arc-shaped inclined surface three 4044 is parallel to the arc-shaped inclined surface one 3032, at this time, the hollow cylindrical frame two 4041 is extruded under the action of the reset force of the spring 4051, and the hollow cylindrical frame two 4041 is rotated and rises under the cooperation of the arc-shaped inclined surface three 4044 and the arc-shaped inclined surface one 3032, in the rising process, the arc-shaped limiting block two 4043 moves along the gap between the two groups of arc-shaped limiting parts 303, until the arc-shaped limiting block two 4043 contacts with the top end of the limiting groove 3034, the endotoxin ampoule on the top end of the limiting plate 4045 is lifted by the rotation and rising of the hollow cylindrical frame two 4041, so that the endotoxin ampoule can be conveniently taken out.

[0033] When the endotoxin ampoule needs to be placed on the top end of the limiting plate 4045 in the clamping part 404, the hollow cylindrical frame one 401 is vertically lowered along the limiting groove 3034 of the arc-shaped limiting part 303 in the clamping hole 3 by pressing the protective top cover 5, the arc-shaped limiting block two 4043 is moved along the gap between the two groups of arc-shaped limiting parts 303 by extrusion of the arc-shaped inclined surface two 402 on the arc-shaped inclined surface three 4044, and the hollow cylindrical frame two 4041 is extruded on the spring 4051 along the fixed seat 4052 in the spring part 405 by the arc-shaped inclined surface three 4044 and the limiting inclined block 3033, until the arc-shaped inclined surface three 4044 is parallel to the limiting inclined block 3033, at this time, the hollow cylindrical frame two 4041 is extruded under the action of the reset force of the spring 4051, and the hollow cylindrical frame two 4041 is rotated and rises under the cooperation of the arc-shaped inclined surface three 4044 and the limiting inclined block 3033, in the rising process, the arc-shaped limiting block two 4043 moves along the gap between the two groups of arc-shaped limiting blocks one 3031, until the arc-shaped limiting block two 4043 is in complete contact with the limiting inclined block 3033, and the hollow cylindrical frame two 4041 is fixed by the cooperation of the arc-shaped limiting block one 3031 and the spring 4051, and the endotoxin ampoule is protected and stored.

[0034] In order to facilitate the understanding of the above technical scheme of the present application, the working principle or operation mode of the present application in the actual process will be described in detail.

[0035] In practical application, when the endotoxin ampoule placed on the top end of the limiting plate 4045 in the clamping part 404 needs to be taken out, the kit cover 6 is opened along the detection kit 1 under the cooperation of the hinge, and then the hollow cylindrical frame 1 401 is vertically lowered along the limiting groove 3034 of the arc-shaped limiting part 303 in the clamping hole 3 by pressing the protective top cover 5. The arc-shaped inclined surface three 4044 is separated from the limiting inclined block 3033 by the extrusion of the arc-shaped inclined surface two 402 on the arc-shaped inclined surface three 4044, and the hollow cylindrical frame two 4041 is extruded along the fixed seat 4052 in the spring part 405 to the spring 4051, until the arc-shaped inclined surface three 4044 is parallel to the arc-shaped inclined surface one 3032. At this time, the hollow cylindrical frame two 4041 is extruded under the action of the reset force of the spring 4051, so that the hollow cylindrical frame two 4041 is rotated and rises under the cooperation of the arc-shaped inclined surface three 4044 and the arc-shaped inclined surface one 3032. In the process of rising, the arc-shaped limiting block two 4043 moves along the gap between the two groups of arc-shaped limiting parts 303, until the arc-shaped limiting block two 4043 contacts with the top end of the limiting groove 3034. The endotoxin ampoule on the top end of the limiting plate 4045 is lifted by the rotation of the hollow cylindrical frame two 4041.

[0036] At this time, the protective top cover 5 is removed from the top end of the hollow cylindrical frame one 401 under the cooperation of the anti-skid lines 7, so as to facilitate the taking of the endotoxin ampoule on the top end of the limiting plate 4045.

[0037] When the endotoxin ampoule needs to be placed on the top end of the limiting plate 4045, the endotoxin ampoule is placed on the top end of the limiting plate 4045. Then, the protective top cover 5 is rotated and installed on the top of the hollow cylindrical frame one 401 under the cooperation of the anti-skid lines 7. Then, the hollow cylindrical frame one 401 is vertically lowered along the limiting groove 3034 of the arc-shaped limiting part 303 in the clamping hole 3 by pressing the protective top cover 5. The arc-shaped limiting block two 4043 moves along the gap between the two groups of arc-shaped limiting parts 303 by the extrusion of the arc-shaped inclined surface two 402 on the arc-shaped inclined surface three 4044, and the hollow cylindrical frame two 4041 is extruded along the fixed seat 4052 in the spring part 405 to the spring 4051, until the arc-shaped inclined surface three 4044 is parallel to the limiting inclined block 3033. At this time, the hollow cylindrical frame two 4041 is extruded under the action of the reset force of the spring 4051, so that the hollow cylindrical frame two 4041 is rotated and rises under the cooperation of the arc-shaped inclined surface three 4044 and the limiting inclined block 3033. In the process of rising, the arc-shaped limiting block two 4043 moves along the gap between the two groups of arc-shaped limiting blocks one 3031, until the arc-shaped limiting block two 4043 is in complete contact with the limiting inclined block 3033. The hollow cylindrical frame two 4041 is fixed by the cooperation of the arc-shaped limiting block one 3031 and the spring 4051, and the endotoxin ampoule is protected and stored.

[0038] The working principle of the pick-and-place assembly 4 is as shown above.

[0039] To sum up, by means of the above technical scheme of the utility model, the utility model can effectively detect and quantify bacterial endotoxin in biological products under the cooperation of the detection kit 1, the support frame 2, the clamping hole 3 and the pick-and-place assembly 4, ensure product quality and safety, prevent serious adverse reactions caused by endotoxin, and protect the health of patients; meanwhile, it helps to improve detection efficiency and improve the standardization degree of laboratory work processes, which has important significance for the pharmaceutical, medical and biological product industries; under the cooperation of the clamping hole 3, the pick-and-place assembly 4 and the protective top cover 5, the situation that other ampoules in the detection kit 1 are knocked during the use of the detection kit 1 and the taking and placing of the endotoxin ampoule bottle can be avoided, the operation risk is reduced, the cost loss is reduced, and the detection accuracy and the safety of the laboratory are improved.

[0040] In the utility model, unless there is definite provision and limitation, the terms "mounting", "setting", "connecting", "fixing", "screw connecting" and the like should be understood in a broad sense, for example, it can be fixed connection, or detachable connection, or integrated; it can be mechanical connection, or electrical connection; it can be direct connection, or indirect connection through an intermediate medium; it can be the communication inside two elements or the interaction relationship between two elements, unless there is definite limitation, the above terms in the utility model can be understood according to the specific meaning in the utility model by the ordinary skilled in the art.

[0041] The above is only the preferred embodiment of the utility model, and does not limit the utility model, any modification, equivalent replacement, improvement and the like within the spirit and principle of the utility model should be included in the protection scope of the utility model.

Claims

1. An endotoxin test kit comprising a test kit (1) characterized in that, The inner top of the detection kit (1) is provided with a support frame (2), the top end of the support frame (2) is uniformly provided with a plurality of clamping holes (3), the inner side of the clamping hole (3) is provided with a taking and sending assembly (4) matched with the detection kit (1), and the top end of the taking and sending assembly (4) is provided with a protective top cover (5). The top end of the detection kit (1) is provided with a kit cover (6) matched with the support frame (2).

2. The endotoxin test kit according to claim 1, wherein The clamping hole (3) comprises a through hole (301) formed in the top end of the support frame (2), and the bottom end of the support frame (2) is provided with an annular groove (302) matched with the through hole (301); the inner top of the annular groove (302) is uniformly provided with four groups of arc-shaped limiters (303); gaps are left between the arc-shaped limiters (303) and the support frame (2), and gaps are left between adjacent two groups of arc-shaped limiters (303).

3. The endotoxin test kit according to claim 2, wherein The arc-shaped limiters (303) comprise arc-shaped limit blocks one (3031) symmetrically arranged at the inner top of the annular groove (302); the bottom end of the two groups of arc-shaped limit blocks one (3031) is provided with arc-shaped inclined surfaces one (3032) with the same direction; the two groups of arc-shaped limit blocks one (3031) are provided with limit inclined blocks (3033) matched with the arc-shaped inclined surfaces one (3032); and one side of the limit inclined blocks (3033) is provided with a limit groove (3034) matched with the through hole (301).

4. The endotoxin test kit according to claim 3, wherein The taking and sending assembly (4) comprises a hollow cylindrical frame one (401) arranged in the inner side of the through hole (301) and matched with the protective top cover (5); the bottom end of the hollow cylindrical frame one (401) is arc-shaped and sawtooth-shaped, and arc-shaped inclined surfaces two (402) are formed on both sides of each sawtooth of the arc-shaped sawtooth-shaped; The outer side of the hollow cylindrical frame one (401) is uniformly provided with a plurality of limit protrusions (403) matched with the limit groove (3034), and the central surfaces of the plurality of limit protrusions (403) are respectively parallel to the central surfaces of each sawtooth of the arc-shaped sawtooth-shaped; The inner side of the hollow cylindrical frame one (401) is provided with a clamping piece (404), and the bottom end of the clamping piece (404) is provided with a spring piece (405).

5. The endotoxin test kit according to claim 4, wherein The clamping piece (404) comprises a hollow cylindrical frame two (4041) arranged in the inner side of the hollow cylindrical frame one (401); the outer bottom of the hollow cylindrical frame two (4041) is provided with an annular block (4042); the outer side of the annular block (4042) is uniformly provided with four groups of arc-shaped limit blocks two (4043) matched with the hollow cylindrical frame two (4041); and the top end of the arc-shaped limit blocks two (4043) is provided with arc-shaped inclined surfaces three (4044) matched with the arc-shaped inclined surfaces one (3032) and the arc-shaped inclined surfaces two (402); The inner bottom of the hollow cylindrical frame two (4041) is provided with a limit plate (4045) matched with the spring piece (405).

6. The endotoxin test kit according to claim 5, wherein The spring member (405) comprises a spring (4051) arranged at the bottom end of the hollow cylindrical frame two (4041), and the bottom end of the spring (4051) is provided with a fixing seat (4052) matched with the hollow cylindrical frame two (4041) and the detection kit (1).

7. The endotoxin test kit according to claim 1, wherein The detection kit (1) and the kit cover (6) are connected through a hinge; The outer side of the protective top cover (5) is provided with anti-skid lines (7).

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