A centrifugal oscillation device for rapid detection of veterinary drug residues based on magnetic particles

Abstract

The utility model discloses a centrifugal oscillation device for fast detection of veterinary drug residues based on magnetic corpuscle, it contains box and box lid, be provided with the guide column in the box, be provided with the sliding type vibration plate and fixed plate from below to top on the guide column, the spring is sleeved on the guide column between the fixed plate and vibration plate, the inner chamber bottom of box is provided with vibration motor, be provided with eccentric wheel on the power axle of vibration motor, the eccentric wheel can push the vibration plate up and down vibration, be provided with rotating electrical machine on the fixed plate, the power axle of rotating electrical machine is connected with the rotating disc through connecting shaft, be provided with the jack on the rotating disc, the jack can clamp the sample tube, be provided with locking bolt through the box, locking bolt can fasten or loosen the fixed plate. The utility model can centrifugal rotation and can also up and down oscillation, and centrifugal rotation and oscillation can be set apart, do not influence each other, improve sample mixing effect.

Description

Technical Field

[0001] This utility model relates to a drug residue detection technology, and in particular to a centrifugal oscillation device for rapid detection of veterinary drug residues based on magnetic microparticles. Background Technology

[0002] Colloidal gold immunoassay test strips are commonly used in routine food testing. Magnetic microparticles are colloidal composite materials that can be uniformly dispersed in a base solution. They are composed of magnetic materials (such as magnetite and ferric oxide) combined with polymer materials, possessing characteristics such as superparamagnetism, high specific surface area, and surface-modifiable functional groups. Their particle size is typically 10-100 nanometers. After being coated with materials such as chitosan and polylactic acid, they become hydrophilic, biocompatible, and non-immunogenic, and can immobilize substances such as antigens / antibodies, enzymes, nucleic acids, or drugs. The properties of magnetic microparticles allow for sample purification, making the process easy, quick, and convenient. Magnetic microparticle enrichment methods, as a novel rapid detection technology, are gradually replacing traditional testing methods, offering higher detection sensitivity compared to general test strips. When using magnetic microparticles to detect drug residues, the sample needs to be centrifuged and shaken to extract a qualified supernatant; therefore, a suitable centrifugation and shaking device is essential for improving detection results.

[0003] Authorization announcement number CN222567523U discloses a shaking device for exosome separation, including a base plate, a support plate on the top of the base plate, a set of C-shaped tubes fixedly connected to the top of the support plate, and a set of circular tubes fixedly connected to the bottom of the support plate. A circular rod is fixedly connected to the circular tubes by a spring, and the circular rod is slidably connected inside the circular tubes. The bottom of the circular rods is fixedly connected to the top of the base plate. A vibrating element is provided on the top of the base plate to drive the support plate to vibrate. A fixing component is provided on the support plate to fix the centrifuge tubes. This device addresses the problem that exosomes are extremely viscous and difficult to mix thoroughly with reagents, requiring manual shaking, which is time-consuming and labor-intensive. Insufficient shaking can lead to long exosome lysis times.

[0004] However, this technical solution has some shortcomings: 1. The power unit of the fixed component includes multiple rotating wheels, which has a complex structure and a high failure rate; 2. The vibration component includes a first motor, a Z-shaped rod, a rectangular block and a sliding groove, which has a complex structure and is not easy to replace and maintain. Utility Model Content

[0005] The technical problem to be solved by this utility model is to overcome the shortcomings of existing calibration technology and provide a centrifugal oscillation device for rapid detection of veterinary drug residues based on magnetic particles, which has a reasonable design, simple vibration structure and low maintenance cost.

[0006] The technical solution of this utility model is:

[0007] A centrifugal oscillation device for rapid detection of veterinary drug residues based on magnetic microparticles includes a housing and a lid. A guide column is installed inside the housing, and a vibrating plate and a fixed plate are mounted on the guide column from bottom to top. Both the fixed plate and the vibrating plate are slidably connected to the guide column via guide holes. A spring is fitted onto the guide column between the fixed plate and the vibrating plate. A vibration motor is installed at the bottom of the housing cavity, and an eccentric wheel is mounted on the power shaft of the vibration motor, which pushes the vibrating plate to vibrate up and down. A rotary motor is installed on the fixed plate, and its power shaft is connected to a rotating disk via a connecting shaft. The rotating disk has insertion holes for clamping sample tubes. A locking bolt penetrates the housing, and the inner end of the locking bolt can tighten or loosen the fixed plate.

[0008] Furthermore, a protective plate is provided on the lower surface of the vibrating plate, and the eccentric wheel contacts the protective plate to achieve pushing vibration.

[0009] Furthermore, the inner wall of the upper end of the box plate of the box body is provided with a stepped surface, and a positioning ring plate is provided on the stepped surface. The lower end of the positioning ring plate contacts the upper end of the guide post, and the upper end of the positioning ring plate contacts the lower end of the box cover through a positioning sleeve, so that the guide post can be positioned.

[0010] Furthermore, the outer side of the box is provided with two handles, which are symmetrically arranged to enable the box to be moved.

[0011] Furthermore: an elastic sleeve is provided inside the insertion hole to facilitate clamping the sample tube; the insertion hole is a cylindrical hole or a conical hole; the insertion hole is a through hole or a blind hole.

[0012] The beneficial effects of this utility model are:

[0013] 1. This utility model can both centrifuge and vibrate up and down, and the centrifugal rotation and vibration can be set separately so as not to affect each other, thereby improving the sample mixing effect.

[0014] 2. This utility model utilizes a rotary motor to drive the rotating disk to rotate, and can simultaneously drive multiple sample tubes to rotate, resulting in high working efficiency.

[0015] 3. This utility model utilizes an eccentric wheel to achieve periodic up-and-down vibration, while also providing a protective plate to prevent damage to the vibration plate. The protective plate can also be replaced, reducing usage costs.

[0016] 4. This utility model utilizes a combination of guide post, guide hole and spring to achieve elastic vibration while ensuring the consistency of vibration.

[0017] 5. This utility model is equipped with a positioning ring plate and a positioning sleeve, which can position the guide column and can also be disassembled and replaced.

[0018] 6. This utility model has a reasonable design, a simple vibration structure, and low maintenance costs. It is widely applicable to the centrifugation and vibration of test solutions, easy to promote and implement, and has good economic benefits. Attached Figure Description

[0019] Figure 1 This is a structural diagram of a centrifugal oscillation device for rapid detection of veterinary drug residues based on magnetic microparticles;

[0020] Figure 2 for Figure 1 Top view of the central rotating disk;

[0021] Figure 3 for Figure 1 Side view of the eccentric wheel. Detailed Implementation

[0022] Example 1: See Figure 1 -- Figure 3 In the figure, 1-box body, 2-guide column, 3-spring, 4-locking bolt, 5-handle, 6-positioning ring plate, 7-box cover, 8-rotating disk, 9-elastic sleeve, 10-sample tube, 11-positioning sleeve, 12-rotary motor, 13-fixed plate, 14-vibrating plate, 15-vibrating motor, 16-eccentric wheel, 17-protective plate.

[0023] A centrifugal oscillation device for rapid detection of veterinary drug residues based on magnetic particles includes a housing 1 and a housing cover 7 (the two can be connected by snap-fits or connecting bolts and can be disassembled). The housing 1 contains guide columns 2 (guide columns 2 are arranged on both sides, and one, two, or three can be installed depending on the size of the housing). Vibrating plates 14 and fixing plates 13 are arranged on the guide columns 2 from bottom to top. Both the fixing plate 13 and the vibrating plate 14 are slidably connected to the guide columns 2 through guide holes. A spring 3 is fitted on the guide column 2 between the fixing plate 13 and the vibrating plate 14. A vibration motor 15 is installed at the bottom of the inner cavity of the housing 1. The number of motors 15 is determined by the size of the housing (two are shown in the figure, but one or three are also possible). An eccentric wheel 16 is provided on the power shaft of the vibration motor 15. The eccentric wheel 16 can push the vibration plate 14 to vibrate up and down. A rotary motor 12 is provided on the fixed plate 13. The power shaft of the rotary motor 12 is connected to the rotating disk 8 through the connecting shaft. The rotating disk 8 is provided with a socket that can clamp the sample tube 10. A locking bolt 4 is provided through the housing 1. The inner end of the locking bolt 4 can tighten or loosen the fixed plate 13. There are at least two locking bolts 4, which are symmetrically arranged. Of course, four, six, etc. can also be provided, but not all are listed.

[0024] Preferred solution: A protective plate 17 is provided on the lower surface of the vibrating plate 14, and the eccentric wheel 16 contacts the protective plate 17 to realize the pushing vibration, so as to protect the vibrating plate 14.

[0025] Preferred solution: The inner wall of the upper part of the box plate of the box body 1 is provided with a stepped surface, and a positioning ring plate 6 is provided on the stepped surface. The lower end face of the positioning ring plate 6 contacts the upper end of the guide post 2, and the upper end face of the positioning ring plate 6 contacts the lower end of the box cover 7 through the positioning sleeve 11, so that the guide post 2 can be positioned. In the figure, the bottom of the box body 1 and the lower end face of the box cover 7 are respectively provided with grooves, and the upper and lower ends of the guide post 2 are respectively located in the grooves.

[0026] Preferred solution: The outer side of the box 1 is provided with handles 5. There are two handles 5, which are symmetrically arranged to enable the box 1 to be moved.

[0027] Preferred option: An elastic sleeve 9 is provided inside the insertion hole to facilitate clamping the sample tube 10. The insertion hole is a cylindrical hole or a conical hole; the insertion hole can be a through hole or a blind hole, depending on the actual situation.

[0028] In use, first, in the initial static position, screw in the locking bolt 4 to secure the inner end of the locking bolt 4 to the fixed plate 13, thus preventing the fixed plate 13 from moving up and down. Next, evenly place the sample tube 10 into the insertion hole of the rotating plate 8, start the rotating motor 12 to drive the rotating plate 8 to rotate, causing the sample in the sample tube 10 to undergo centrifugal motion. After a predetermined time, the rotating motor 12 stops, completing the centrifugal operation. Then, unscrew the locking bolt 4 to disengage the inner end of the connecting bolt 4 from the fixed plate 13, allowing the fixed plate 13 to move up and down. Start the vibration motor 15, causing the eccentric wheel 16 to rotate periodically, causing the vibrating plate 14 to move up and down periodically. The vibrating plate 14, spring 3, and fixed plate 13 constitute an oscillation mechanism, thereby causing the sample in the sample tube 10 to oscillate. Finally, turn off the vibration motor 15 to stop the oscillation, completing one working cycle.

[0029] Example 2: This example is basically the same as Example 1, and the similarities will not be repeated. The difference is that the lower end of the guide column is fixedly connected to the bottom plate of the inner cavity of the box, and the positioning ring plate and positioning sleeve are no longer set to simplify the structure.

[0030] The above description is merely a preferred embodiment of the present utility model and is not intended to limit the present utility model in any way. Any simple modifications made based on the technical essence of the present utility model shall still fall within the scope of the technical solution of the present utility model.

Claims

1. A centrifugal oscillation device for rapid detection of veterinary drug residues based on magnetic microparticles, comprising a housing and a lid, characterized in that: The chamber is equipped with guide columns, on which vibrating plates and fixed plates are mounted from bottom to top. Both the fixed plate and the vibrating plate are slidably connected to the guide columns through guide holes. A spring is fitted on the guide column between the fixed plate and the vibrating plate. A vibration motor is installed at the bottom of the chamber's inner cavity. An eccentric wheel is mounted on the power shaft of the vibration motor, which can push the vibrating plate to vibrate up and down. A rotary motor is installed on the fixed plate, and its power shaft is connected to a rotating disk through a connecting shaft. The rotating disk has insertion holes for clamping sample tubes. A locking bolt is installed through the chamber, and its inner end can tighten or loosen the fixed plate.

2. The centrifugal oscillation device for rapid detection of veterinary drug residues based on magnetic microparticles according to claim 1, characterized in that: The lower surface of the vibrating plate is provided with a protective plate, and the eccentric wheel contacts the protective plate to achieve pushing vibration.

3. The centrifugal oscillation device for rapid detection of veterinary drug residues based on magnetic microparticles according to claim 1, characterized in that: The inner wall of the upper part of the box plate of the box body is provided with a stepped surface, and a positioning ring plate is provided on the stepped surface. The lower end of the positioning ring plate contacts the upper end of the guide post, and the upper end of the positioning ring plate contacts the lower end of the box cover through a positioning sleeve, so that the guide post can be positioned.

4. The centrifugal oscillation device for rapid detection of veterinary drug residues based on magnetic microparticles according to claim 1, characterized in that: The outer side of the box is provided with two handles, which are symmetrically arranged to enable the box to be moved.

5. The centrifugal oscillation device for rapid detection of veterinary drug residues based on magnetic microparticles according to claim 1, characterized in that: An elastic sleeve is provided inside the insertion hole to facilitate clamping the sample tube. The insertion hole is a cylindrical hole or a conical hole; the insertion hole is a through hole or a blind hole.

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