A biochemical component analysis device for multi-form clinical samples

Abstract

The utility model discloses a kind of biochemical component analysis devices of multi-form clinical sample, comprising: POCT mass spectrometer, operation and display panel, heating controller and heating gasification device connected in turn electricity;Heating gasification device is used to heat the clinical sample of multiple states;POCT mass spectrometer is used to identify gas component;Heating controller is used to control heating gasification device work;Operation and display panel are used to send the operation signal of user to heating controller and POCT mass spectrometer, receive and show gas component analysis data;Heating gasification device includes: cavity heating body, sealing cover, gas cover, gas pipe and heating dish;Cavity heating body top opening, bottom is equipped with electric heating disc;Heating dish is placed on electric heating disc;Sealing cover is detachably sealed with the upper end of cavity heating body;Gas cover, its lower end opening and cover on heating dish.The utility model has portability and easy operation, can be used for gaseous, liquid, solid, semi-solid etc. Various clinical sample smell molecule analysis.

Description

Technical Field

[0001] This utility model relates to the field of odor diagnosis technology, and in particular to a biochemical component analysis device for multi-morphological clinical samples. Background Technology

[0002] The four diagnostic methods of Traditional Chinese Medicine (TCM): observation, auscultation, inquiry, and palpation, are the core and essence of basic TCM diagnosis. Auscultation refers to the method by which doctors understand a patient's health status and diagnose diseases by listening to sounds and distinguishing odors. Smell diagnosis specifically involves smelling and distinguishing the patient's body odor from the odor of the sickroom to diagnose diseases. According to literature reports, numerous studies both domestically and internationally have explored the correlation between human odor molecules and various diseases, such as heart failure, lung cancer, and colorectal cancer. With the development of modern science, smell diagnosis is gradually moving towards objectivity, digitization, and intelligence, forming the direction of "digitalized and intelligent TCM smell diagnosis." Currently, the main analytical techniques that can be used for digitalized and intelligent TCM smell diagnosis include chromatography, mass spectrometry (MS), spectroscopy, and ion mobility spectrometry (IMS).

[0003] While chromatography can separate mixtures, it relies on pretreatment and is time-consuming. Spectroscopy has limited ability to distinguish complex odor components, and ion mobility spectrometry has shortcomings in component selectivity and sensitivity. Mass spectrometry, with its high sensitivity, high resolution, and ability to simultaneously detect multiple components, can accurately detect trace amounts of volatile organic compounds (VOCs) in human body odor. It is suitable for multi-dimensional analysis of complex odor samples in traditional Chinese medicine olfactory diagnosis, has the potential to discover disease-related biomarkers, and provides a reliable basis for establishing objective diagnostic models.

[0004] However, traditional mass spectrometers are bulky, complex to operate, and expensive, making them unsuitable for dynamic, on-site testing scenarios. Point-of-Care Testing (POCT) mass spectrometers are small-scale testing systems that integrate rapid sample processing, real-time mass spectrometry analysis, and intelligent diagnosis. They extend the testing capabilities of traditional laboratory mass spectrometers to bedside, community healthcare, or home settings, making rapid and accurate digital TCM olfactory diagnosis possible and demonstrating great application potential. This technology not only compensates for the shortcomings of traditional mass spectrometers in qualitative and quantitative analysis, bringing mass spectrometry analysis from the laboratory to the clinical front line, but also contributes to the standardization, intelligentization, and digitalization of TCM olfactory diagnosis.

[0005] Currently, most POCT mass spectrometers can only detect gaseous or liquid substances individually, and cannot detect the biochemical components of multiple forms of clinical samples simultaneously. They also lack heating capabilities and cannot distinguish between mixed samples. Utility Model Content

[0006] This invention provides a biochemical component analysis device for multi-form clinical samples based on the principle of POCT mass spectrometry, which can analyze odor molecules in clinical samples of various states (such as gaseous, liquid, solid, semi-solid, etc.) to solve the technical problems existing in the prior art.

[0007] The technical solution adopted by this utility model to solve the technical problems existing in the prior art is as follows: A biochemical composition analysis device for multi-form clinical samples includes: a POCT mass spectrometer, an operation and display panel, a heating controller, and a heating vaporization device connected in sequence; the heating vaporization device is used to heat clinical samples of various forms; the POCT mass spectrometer is used to identify the gaseous components obtained after heating the clinical samples of various forms; the heating controller is used to control the operation of the heating vaporization device; the operation and display panel is used to send user operation signals to the heating controller and the POCT mass spectrometer, and to receive and display gaseous composition analysis data from the POCT mass spectrometer; The heating and vaporization device includes: a cavity heating element, a sealing cover, a gas-gathering hood, a gas outlet pipe, and a heating dish; the cavity heating element has an opening at the top and an electric heating plate at the bottom; the heating dish is used to hold clinical samples and is placed on the electric heating plate; the sealing cover is detachably and sealingly connected to the upper end of the cavity heating element; the gas outlet pipe sealably passes through the side wall of the cavity heating element; the gas-gathering hood is located inside the cavity heating element, has an opening at its lower end and covers the heating dish, and its cross-sectional area gradually decreases from bottom to top; its upper end has a gas outlet hole that connects to the gas outlet pipe; the heating controller receives signals from the operation and display panel and outputs a voltage signal to the electric heating plate.

[0008] Furthermore, the cavity heating body has a feed inlet on its side wall, and the heating and gasification device is equipped with a drawer-type feed door for opening and closing the feed inlet; the cavity heating body is equipped with double slide rails, and telescopic double slide rails are correspondingly provided in the double slide rails and slide in cooperation with the slide rails; the feed door is fixedly connected to the extended end of the double slide rails; the upper port of the heating dish is provided with an outwardly extending edge; the double slide rails are provided with a bracket that overlaps the outer edge of the heating dish; when the feed door is opened, the double slide rails extend from the slide rails and overlap the outer edge of the heating dish on the bracket; when the feed door is pushed in, the double slide rails retract into the slide rails, so that the feed door closes the feed inlet and moves the heating dish to the electric heating plate.

[0009] Furthermore, an electric shut-off valve is provided at the outlet end of the gas pipe of the heating and gasification device; the heating controller outputs an electrical signal to the electric shut-off valve to control the opening and closing of the electric shut-off valve.

[0010] Furthermore, the heating controller is equipped with multiple heating modes. The operation and display panel has a numeric keypad and / or a multi-position switch for selecting the heating mode. Each position of the multi-position switch corresponds to a heating mode. The multi-position switch can be a rotary multi-position switch or a binary DIP switch combination multi-position switch. The binary DIP switch combination multi-position switch includes multiple DIP switches. Each DIP switch is independently set to an on or off state. When the DIP switch is set to the on state, its binary code is 1; when the DIP switch is set to the off state, its binary code is 0. Different heating modes are represented by different combinations of DIP switches in different positions.

[0011] Furthermore, a temperature sensor is provided inside and / or on the surface of the electric heating plate; the temperature sensor is electrically connected to the heating controller, which includes a comparator. The two input terminals of the comparator are respectively input to the detected value of the temperature sensor and the temperature set value. The heating controller adjusts the voltage output to the electric heating plate according to the output signal of the comparator.

[0012] Furthermore, the operation and display panel is equipped with working status indicator lights and an LCD display; the heating controller outputs a digital temperature signal to the LCD display, which displays the internal or surface temperature of the electric heating plate.

[0013] Furthermore, the operation and display panel is a handheld panel, and the operation and display panel communicates wirelessly with the heating controller and the POCT mass spectrometer.

[0014] Furthermore, the operation and display panel is a human-machine interface.

[0015] Furthermore, a POCT mass spectrometer includes a sample introduction system, an ion source, an ion funnel, an ion trap, a detector, and a data processor; The sample introduction system is used to introduce the gas obtained after heating the clinical sample into the POCT mass spectrometer; the sample introduction system includes an inlet tube; Ion sources are used to ionize gas molecules into charged ions; Ion funnels are used to focus and transport ions; Ion traps are used to separate ions using electromagnetic fields; The detector is used to capture and measure the ion signal after separation by the ion trap; The data processor is used to process and analyze the data collected by the detector; The inlet end of the POCT mass spectrometer's gas inlet pipe is connected to the outlet end of the heating and vaporization device's gas outlet pipe.

[0016] Furthermore, the gas-concentrating hood includes a conical or pyramidal frame with an opening at the top, the frame being covered with a metal membrane inside or outside, and the gas-concentrating hood and the exhaust pipe being detachably assembled together.

[0017] The advantages and positive effects of this utility model are: This invention relates to a biochemical component analysis device for multi-form clinical samples. It is equipped with a heating and vaporization device that can heat odor molecules in clinical samples of various states (such as gaseous, liquid, solid, and semi-solid states). The device is then used to detect these molecules based on the analytical principle of POCT mass spectrometry. The detection signals are used for qualitative or quantitative analysis, thereby helping doctors understand the patient's physical condition and assisting in clinical diagnosis.

[0018] This utility model relates to a biochemical component analysis device for multi-form clinical samples. It is small in size, easy to operate, fast in analysis speed, and inexpensive. It can be used to analyze odor molecules in clinical samples in various states (such as gaseous, liquid, solid, and semi-solid). Through the operation and display panel, the heating parameters are set according to the boiling point differences of the compounds in the sample, and the compounds are separated in a time sequence by the boiling point differences. Attached Figure Description

[0019] Figure 1 This is a schematic diagram of the structure of a biochemical component analysis device for multi-morphological clinical samples according to this utility model.

[0020] Figure 2 This is a block diagram illustrating the control principle of a biochemical component analysis device for multi-morphological clinical samples according to this utility model.

[0021] In the diagram: 1. Sealing cap; 2. Electric shut-off valve; 3. Gas outlet pipe; 4. Gas gathering hood; 5. Heating dish; 6. Cavity heating element; 7. Electric heating plate; 8. POCT mass spectrometer inlet pipe; 9. Quick-connect tube connector; 10. POCT mass spectrometer. Detailed Implementation

[0022] The present invention will now be described in detail with reference to the accompanying drawings and embodiments. It should be understood that the preferred embodiments described herein are for illustration and explanation only and are not intended to limit the present invention.

[0023] In the description of this utility model, the terms "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," and "bottom," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this utility model and do not require that this utility model be constructed and operated in a specific orientation; therefore, they should not be construed as limitations on this utility model. The terms "connected" and "linked" used in this utility model should be interpreted broadly. For example, they can refer to a fixed connection or a detachable connection; a direct connection or an indirect connection through intermediate components; or an electrical connection or signal transmission. Those skilled in the art can understand the specific meaning of the above terms according to the specific circumstances.

[0024] Please see Figures 1 to 2 A biochemical composition analysis device for multi-form clinical samples includes: a POCT mass spectrometer 10, an operation and display panel, a heating controller, and a heating vaporization device connected in sequence; the heating vaporization device is used to heat clinical samples of various forms; the POCT mass spectrometer 10 is used to identify the gas components obtained after heating the clinical samples of various forms; the heating controller is used to control the operation of the heating vaporization device; the operation and display panel is used to send user operation signals to the heating controller and the POCT mass spectrometer 10, and to receive and display gas composition analysis data from the POCT mass spectrometer 10.

[0025] The heating and vaporization device includes: a cavity heating body 6, a sealing cover 1, a gas gathering hood 4, a gas outlet pipe 3, and a heating dish 5; the cavity heating body 6 has an opening at the top and an electric heating plate 7 at the bottom; the heating dish 5 is used to hold the sample and is placed on the electric heating plate 7; the sealing cover 1 is detachably and sealed to the upper end of the cavity heating body 6; the gas outlet pipe 3 passes through the side wall of the cavity heating body 6 in a sealed manner; the gas gathering hood 4 is located inside the cavity heating body 6, with an opening at the lower end covering the heating dish 5, and its cross-sectional area gradually decreases from bottom to top; its upper end has a gas outlet hole that connects to the gas outlet pipe 3.

[0026] The heating controller receives signals from the operation and display panel, such as start commands and heating temperatures, and outputs voltage signals to the electric heating plate 7. POCT mass spectrometry includes an ion funnel, ion trap, cooling fan, circuit board, and an inlet pipe connected to it; the inlet end of the POCT mass spectrometer inlet pipe is connected to the outlet end of the heating and vaporization device; the ion funnel, ion trap, cooling fan, and circuit board are located inside the mass spectrometer and are used to detect samples.

[0027] Preferably, the POCT mass spectrometer 10 may include a sample introduction system, an ion source, an ion funnel, an ion trap, a detector, and a data processor; The sample introduction system is used to introduce the gas obtained after heating the clinical sample into the POCT mass spectrometer 10; the sample introduction system includes an inlet tube.

[0028] An ion source is used to ionize gas molecules into charged ions.

[0029] Ion funnels are used to focus and transport ions.

[0030] Ion traps are used to separate ions using electromagnetic fields.

[0031] The detector is used to capture and measure the ion signal after separation by the ion trap.

[0032] The data processor is used to process and analyze the data collected by the detector.

[0033] The inlet end of the POCT mass spectrometer's gas inlet pipe 8 and the outlet end of the heating and vaporization device can be connected via a quick-connect pipe fitting 9.

[0034] The electric heating plate 7 can be embedded with an electric heating element. The electric heating element is electrically connected to the heating controller. The heating controller outputs the corresponding voltage to the electric heating element according to the heating temperature input on the operation and display panel.

[0035] The electric heating plate 7 can be embedded with a metal-ceramic heating element (MCH) ceramic heating element. The core principle of the metal-ceramic heating element (MCH) ceramic heating element is to embed the metal resistance heating layer into the ceramic substrate through high-temperature co-fired multilayer ceramic substrate technology, and to achieve efficient electrothermal conversion by utilizing the Joule effect generated by the current passing through the resistance material.

[0036] The system employs a detachable sealing connection between the sealing cap 1 and the upper end of the cavity heating element 6, and uses a heating dish 5 to hold the sample; this facilitates the cleaning of sample residues and sample replacement; it also facilitates the removal of residual gas from the sample, making it easier to perform component analysis on the next sample.

[0037] Preferably, the cavity heating element 6 has a feed inlet on its side wall, and the heating and vaporization device is equipped with a drawer-type feed door for opening and closing the feed inlet; the cavity heating element is equipped with double slide rails, and telescopic double slide rails are correspondingly provided in the double slide rails to slide with the slide rails; the feed door is fixedly connected to the extended ends of the double slide rails; the upper port of the heating dish has an outwardly extending edge; the double slide rails are equipped with brackets that overlap the outer edge of the heating dish; when the feed door is opened, the double slide rails extend from the slide rails and overlap the outer edge of the heating dish on the brackets; when the feed door is pushed in, the double slide rails retract into the slide rails, so that the feed door closes the feed inlet and transfers the heating dish to the electric heating plate. The bracket can be a square or round bracket, or it can be composed of two arc-shaped brackets.

[0038] Preferably, an electric shut-off valve 2 may be provided at the outlet end of the gas outlet pipe 3 of the heating and gasification device; the heating controller outputs an electrical signal to the electric shut-off valve 2 to control the opening and closing of the electric shut-off valve 2.

[0039] The electric shut-off valve 2 can utilize the German Memetis normally closed micro-valve. The Memetis normally closed micro-valve is only 5 mm wide, allowing for the integration of multiple valves within a small installation space, thus achieving a powerful fluid system. The current regulating valve offers noiseless switching, proportional control, and media separation. Its working principle is as follows: when the current is applied, the actuator acts on the spring element, releasing a ball from the valve opening, thus opening the pipeline. When the current is turned off, the spring element pushes the ball back onto the valve opening, closing the pipeline.

[0040] Preferably, the heating controller may include a comparator and an amplifier. The two input terminals of the comparator correspond to the detection value of the temperature sensor and the temperature set value. The comparator outputs a signal to the amplifier, and the amplifier outputs a voltage to the electric heating plate.

[0041] The heating controller can also be a PLC controller and a power pulse width modulator. The PLC controller takes heating process parameters from the operation and display panel as input and outputs control signals to the power pulse width modulator, which then changes the output voltage by adjusting the pulse width.

[0042] Preferably, the heating controller can be set to multiple heating working modes, and the operation and display panel can be equipped with a numeric keypad and / or a multi-position switch for selecting the heating working mode. Each position of the multi-position switch corresponds to a heating working mode. The multi-position switch can be a rotary multi-position switch or a binary DIP switch combination multi-position switch. The binary DIP switch combination multi-position switch can include multiple DIP switches. Each DIP switch is independently set to an on or off state. When the DIP switch is set to the on state, its binary code is 1; when the DIP switch is set to the off state, its binary code is 0. Different heating working modes are represented by different combinations of DIP switches in different positions.

[0043] Preferably, a temperature sensor may be provided inside the electric heating plate 7 and / or on the surface of the electric heating plate 7; the temperature sensor is electrically connected to the heating controller, and the detection signal of the temperature sensor can be used as a temperature feedback signal input to the heating controller. The heating controller includes a comparator, and the two input terminals of the comparator are respectively input to the detection value of the temperature sensor and the temperature set value. The heating controller adjusts the voltage output to the electric heating plate according to the output signal of the comparator.

[0044] Preferably, the operation and display panel includes a working status indicator light and an LCD display; the heating controller outputs a digital temperature signal to the LCD display, which displays the internal or surface temperature of the electric heating plate 7. The LCD display can also display the heating time and heating curve.

[0045] Preferably, the operation and display panel can be a text display with a numeric keypad, a human-machine interface, or other similar device.

[0046] Preferably, the operation and display panel is a handheld operation panel, and the operation and display panel communicates wirelessly with the heating controller and the POCT mass spectrometer 10. The operation and display panel can be a mobile phone, tablet, or other device, and can input heating process parameters to the heating controller through a built-in application.

[0047] Preferably, the device may also include a housing, with the heating controller and heating vaporization device all mounted on the housing, forming an integrated portable structure. A heat insulation layer is provided between the heating controller and the heating vaporization device. The housing is provided with an insulation sleeve made of heat-insulating material, and the cavity heating element 6 is located inside the insulation sleeve.

[0048] The insulation layer can be made of materials such as rock wool, glass wool, and expanded perlite. These materials not only have good insulation properties, but also good fire resistance and chemical stability.

[0049] Insulation materials can include glass wool, rock wool, and aluminum silicate fiber. These materials have good high-temperature resistance, chemical stability, and fire-retardant properties.

[0050] Preferably, the gas-gathering hood 4 may include a conical or pyramidal frame with a pipe opening at the top, the frame being covered with a metal membrane inside or outside, and the gas-gathering hood 4 and the gas outlet pipe 3 can be detachably assembled together.

[0051] The metal film can be made of stainless steel foil, aluminum foil, copper foil, or other metal films. A conical or pyramidal frame with an opening at the top can be made first, and the metal film can be attached to the frame to form a near-conical or near-pyramidal gas-gathering hood 4. The gas-gathering hood 4 and the exhaust pipe 3 can be detached and assembled. For example, the opening of the gas-gathering hood 4 has internal threads, and the exhaust pipe 3 has external threads. The two are connected by threads, and the height of the gas-gathering hood 4 can be adjusted.

[0052] This invention also provides a method for using the above-mentioned biochemical component analysis device for multi-morphological clinical samples, the method comprising the following steps: Place the heating dish 5 on the electric heating plate 7, and seal the sealing cover 1 to the upper end of the cavity heating body 6.

[0053] If a feed inlet and a drawer-type feed door are provided, open the feed door, attach the outer edge of the heating dish 5 to the bracket, push the feed door in, close the feed door, and transfer the heating dish 5 to the electric heating plate.

[0054] Connect the POCT mass spectrometer inlet pipe 8 to the outlet pipe 3 of the heating vaporization device; if an electric shut-off valve 2 is installed at the outlet end of the heating vaporization device outlet pipe 3, the heating controller outputs an electrical signal to the electric shut-off valve 2 to control the electric shut-off valve 2 to open. This connects the POCT mass spectrometer inlet pipe 8 to the heating vaporization device outlet pipe 3.

[0055] Heating parameters can be set on the operation and display panel based on the differences in boiling points of the compound components, and a heating start signal can be issued.

[0056] The heating controller outputs the corresponding voltage to the electric heating tube based on the heating process parameters and heating start signal input from the operation and display panel. The electric heating tube then starts working, heating the sample in the heating dish 5 and gradually vaporizing it.

[0057] The gas emitted from the sample enters the POCT mass spectrometer 10 for analysis; the time-sequential separation of compounds is achieved by the difference in boiling points of the components.

[0058] After the POCT mass spectrometry analysis is completed, open the sealing cap 1 and replace or clean the heating dish 5.

[0059] If a feed inlet and a drawer-type feed door are provided, the feed door can be opened, the heating dish 5 can be removed from the support, and the feed door can be pushed in to close the feed inlet.

[0060] The aforementioned cavity heating element 6, sealing cover 1, gas gathering hood 4, gas outlet pipe, heating dish 5, electric shut-off valve 2, POCT mass spectrometer, gas inlet pipe, power pulse width modulator, rotary multi-position switch, binary DIP combination multi-position switch, temperature sensor, PLC controller, operation and display panel, indicator light, liquid crystal display, housing, text display, human-machine interface, heat insulation layer, heat insulation sleeve, mobile phone, tablet, sample introduction system, ion source, ion funnel, ion trap, detector, data processor, etc. can all adopt the devices and structures applicable in the prior art, or adopt the devices, structures and software applicable in the prior art and construct and implement them using conventional technical means and instructions.

[0061] The embodiments described above are only used to illustrate the technical ideas and features of this utility model. Their purpose is to enable those skilled in the art to understand the content of this utility model and implement it accordingly. The patent scope of this utility model should not be limited by these embodiments. That is, any equivalent changes or modifications made to the spirit disclosed in this utility model still fall within the patent scope of this utility model.

Claims

1. A biochemical component analysis device for multi-morphological clinical samples, characterized in that, include: The POCT mass spectrometer, operation and display panel, heating controller and heating vaporization device are connected in sequence. The heating vaporization device is used to heat clinical samples in various states; the POCT mass spectrometer is used to identify the gas components obtained after heating clinical samples in various states; the heating controller is used to control the operation of the heating vaporization device; the operation and display panel is used to send user operation signals to the heating controller and POCT mass spectrometer, and to receive and display gas component analysis data from the POCT mass spectrometer. The heating and vaporization device includes: a cavity heating element, a sealing cover, a gas-gathering hood, a gas outlet pipe, and a heating dish; the cavity heating element has an opening at the top and an electric heating plate at the bottom; the heating dish is used to hold clinical samples and is placed on the electric heating plate; the sealing cover is detachably and sealingly connected to the upper end of the cavity heating element; the gas outlet pipe sealably passes through the side wall of the cavity heating element; the gas-gathering hood is located inside the cavity heating element, has an opening at its lower end and covers the heating dish, and its cross-sectional area gradually decreases from bottom to top; its upper end has a gas outlet hole that connects to the gas outlet pipe; the heating controller receives signals from the operation and display panel and outputs a voltage signal to the electric heating plate.

2. The multi-form clinical sample biochemical constituent analyzer of claim 1, wherein, The cavity heating element has a feed inlet on its side wall, and the heating and gasification device is equipped with a drawer-type feed door for opening and closing the feed inlet. The cavity heating element has double slides, and telescopic double slide rails that slide in conjunction with the slides are provided in the double slides. The feed door is fixedly connected to the extended ends of the double slide rails. The upper port of the heating dish has an outwardly extending edge. The double slide rails have a bracket that overlaps the outer edge of the heating dish. When the feed door is opened, the double slide rails extend from the slides and overlap the outer edge of the heating dish on the bracket. When the feed door is pushed in, the double slide rails retract into the slides, so that the feed door closes the feed inlet and the heating dish is transferred to the electric heating plate.

3. The multi-form clinical sample biochemical constituent analyzer of claim 1, wherein, An electric shut-off valve is installed at the outlet end of the gas pipe of the heating and gasification device; the heating controller outputs an electrical signal to the electric shut-off valve to control the opening and closing of the electric shut-off valve.

4. The multi-form clinical sample biochemical constituent analyzer of claim 1, wherein, The heating controller has multiple heating modes. The operation and display panel has a numeric keypad and / or a multi-position switch for selecting the heating mode. Each position of the multi-position switch corresponds to a heating mode. The multi-position switch can be a rotary multi-position switch or a binary DIP switch combination multi-position switch. The binary DIP switch combination multi-position switch includes multiple DIP switches. Each DIP switch is independently set to an on or off state. When the DIP switch is set to the on state, its binary code is 1; when the DIP switch is set to the off state, its binary code is 0. Different heating modes are represented by different combinations of DIP switches in different positions.

5. The apparatus of claim 1, wherein A temperature sensor is provided inside and / or on the surface of the electric heating plate; the temperature sensor is electrically connected to the heating controller, which includes a comparator. The two input terminals of the comparator are respectively input to the detected value of the temperature sensor and the temperature set value. The heating controller adjusts the voltage output to the electric heating plate according to the output signal of the comparator.

6. The multi-form clinical sample biochemical constituent analyzer of claim 5, wherein, The operation and display panel is equipped with working status indicator lights and an LCD display; the heating controller outputs a digital temperature signal to the LCD display, which displays the internal or surface temperature of the electric heating plate.

7. The apparatus of claim 1, wherein The operation and display panel is a handheld panel, and it communicates wirelessly with the heating controller and POCT mass spectrometer.

8. The multi-form clinical sample biochemical constituent analyzer of claim 1, wherein, The operation and display panel is a human-computer interface.

9. The multi-form clinical sample biochemical constituent analyzer of claim 1, wherein, A POCT mass spectrometer includes a sample introduction system, ion source, ion funnel, ion trap, detector, and data processor. The sample introduction system is used to introduce the gas obtained after heating the clinical sample into the POCT mass spectrometer; the sample introduction system includes an inlet tube; Ion sources are used to ionize gas molecules into charged ions; Ion funnels are used to focus and transport ions; Ion traps are used to separate ions using electromagnetic fields; The detector is used to capture and measure the ion signal after separation by the ion trap; The data processor is used to process and analyze the data collected by the detector; The inlet end of the POCT mass spectrometer's gas inlet pipe is connected to the outlet end of the heating and vaporization device's gas outlet pipe.

10. The apparatus of claim 1, wherein, The gas-concentrating hood includes a conical or pyramidal frame with an opening at the top, and the frame is covered with a metal membrane inside or outside. The gas-concentrating hood and the exhaust pipe can be detachably assembled together.

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