Solid preparation hot-melt medicine pulverizing device

Abstract

The utility model relates to the technical field of medicine manufacturing, concretely to solid preparation hot melt medicine crushing device for applicable. Including: cooling extrusion roller, its inside is provided with cooling water channel, is used for the cooling water and is cooled and extrusion forming to hot melt material, transmission system, sets up in the discharge side of cooling extrusion roller, is used for the acceptance and delivery hot melt material, crushing system, sets up in the discharge side of transmission system, is used for the crushing to hot melt material, discharge port, with the discharge end of crushing system links to each other, is used for the discharge after the crushing of hot melt material. Cooling extrusion roller and transmission system between setting up cooling roller, its inside is provided with cooling water channel, is used for the cooling water and is cooled and delivery to hot melt material. It can solve the problem such as difficult processing of sticky material, heat sensitive component inactivation and uneven particle size distribution.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical manufacturing technology, specifically to a solid dosage form hot melt pharmaceutical pulverizing device. Background Technology

[0002] Current pharmaceutical pulverization processes face three major technical bottlenecks: First, handling highly viscous materials is difficult. Traditional mechanical pulverization equipment is prone to material adhesion to the inner wall of the pulverizing chamber and the surface of the blades when processing highly viscous materials such as traditional Chinese medicine extracts and soft capsule contents. This leads to poor material discharge, reduced efficiency, and cross-contamination. Second, heat-sensitive components are easily deactivated. Under high-speed mechanical impact and shearing, the mechanical heat generated during pulverization is difficult to dissipate effectively, causing a significant increase in the local temperature of the material. This results in the degradation or deactivation of heat-sensitive active ingredients such as proteins, peptides, and vitamins. Third, the finished product has a wide particle size distribution and poor uniformity. Traditional pulverization processes lack the precision to control particle size, making it difficult to meet the requirements of pharmaceutical formulation processes that have strict requirements for particle size and distribution.

[0003] In summary, existing pulverizing equipment still has significant shortcomings in terms of anti-adhesion, temperature control accuracy, and particle size distribution regulation when processing drug raw materials with high viscosity, heat sensitivity, and strict particle size control requirements, which restricts the preparation of high-quality drugs. Utility Model Content

[0004] In order to solve the technical problems existing in the background art, this utility model provides a solid dosage form hot melt drug pulverizing device, which can solve the problems of difficult handling of viscous materials, deactivation of heat-sensitive components and uneven particle size distribution.

[0005] The technical solution adopted by this utility model to solve its technical problem is: Suitable for solid dosage form hot melt pharmaceutical pulverizing devices, including: The cooling extrusion roller has a cooling water channel inside, which is used to introduce cooling water and cool and extrude the hot molten material. The transmission system, located on the discharge side of the cooling extrusion roller, is used to receive and transport hot melt materials; The crushing system, located on the discharge side of the transmission system, is used to crush hot-melt materials; The discharge port is connected to the discharge end of the crushing system and is used to discharge the crushed hot melt material.

[0006] Furthermore, a cooling roller is provided between the cooling extrusion roller and the transmission system. The cooling roller has a cooling water channel inside, which is used to introduce cooling water and cool and transport the hot melt material.

[0007] Furthermore, a cooling coil is installed below the transmission system, with a cooling water channel inside, for introducing cooling water and cooling the hot molten material on the transmission system.

[0008] Furthermore, a cooling system is installed above the transmission system. The cooling system is used to blow cooling airflow onto the hot molten material on the transmission system to achieve cooling.

[0009] Furthermore, a temperature probe is installed on the discharge side of the transmission system to detect the temperature of the hot-melt material.

[0010] Furthermore, a pre-crushing system is provided between the transmission system and the crushing system for preliminary crushing of the hot-melt material.

[0011] Furthermore, there are two cooling extrusion rollers, which are arranged opposite each other to form an extrusion channel for extruding hot melt materials.

[0012] The beneficial effects of this utility model are: (1) The hot melt material is initially cooled and extruded by the cooling extrusion roller, which transforms it from a viscous flow state into a solid sheet with a certain shape and strength. This effectively reduces the viscosity of the hot melt material and avoids the sticking and clogging problems in the subsequent conveying and crushing process, laying a solid foundation for the subsequent crushing process.

[0013] (2) Along the conveying path of the hot melt material, a cooling roller, a cooling coil below the transmission system, and a cold air system above are sequentially installed, forming a multi-dimensional, progressive cooling system from bottom contact cooling to top convection cooling. This significantly increases the cooling area and cooling efficiency, ensuring that the hot melt material can be uniformly and fully cooled to below the brittle temperature from the inside out before entering the crushing system, thereby greatly improving the crushing effect and product quality.

[0014] (3) By setting up a pre-crushing system, the cooled and shaped hot melt material can be initially crushed, breaking down large pieces of hot melt material into smaller particles. This achieves a reasonable division of labor between coarse and fine crushing, improves the overall crushing efficiency, reduces equipment wear, and makes the output particle size more uniform.

[0015] (4) By setting a temperature probe, the actual temperature of the hot melt material before entering the crushing system can be monitored in real time, thus achieving precise control of the process. This prevents the hot melt material from sticking to the blade or clumping due to insufficient cooling, and also avoids energy waste or even changes in the properties of the hot melt material caused by excessive cooling, ensuring the continuity and stability of the production process. Attached Figure Description

[0016] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0017] Figure 1 This is a schematic diagram of the structure of this utility model.

[0018] In the picture: 1. Cooling extrusion roller, 2. Cooling roller, 3. Transmission system, 4. Cooling air system, 5. Pre-crushing system, 6. Crushing system, 7. Discharge port, 8. Cooling coil, 9. Temperature probe. Detailed Implementation

[0019] The present invention will be further described in detail below with reference to the accompanying drawings.

[0020] like Figure 1 As shown, the specific structure of the solid dosage form hot-melt drug pulverizing device includes a cooling extrusion roller 1. The cooling extrusion roller 1 has a cooling water channel inside for introducing cooling water to cool and extrude the hot-melt material. In a specific embodiment, there are two cooling extrusion rollers 1, which are arranged opposite each other to form an extrusion channel for extruding the hot-melt material. The gap between the two cooling extrusion rollers 1 can be adjusted from 0.1mm to 10mm, allowing precise control of the thickness of the extruded hot-melt material. The working pressure of the forming unit composed of the two cooling extrusion rollers 1 is 3-35MPa, and the thickness fluctuation rate of the formed sheet is ≤±3%. A transmission system 3 is located on the discharge side of the cooling extrusion roller 1 to receive and transport the hot-melt material. A pulverizing system 6 is located on the discharge side of the transmission system 3 to pulverize the hot-melt material. A discharge port 7 is connected to the discharge end of the pulverizing system 6 to discharge the pulverized hot-melt material.

[0021] The hot-melt material is initially cooled and extruded by the cooling extrusion roller 1, which transforms it from a viscous flow state into a solid sheet with a certain shape and strength. This effectively reduces the viscosity of the hot-melt material and avoids adhesion and blockage problems in the subsequent conveying and crushing process, laying a solid foundation for the subsequent crushing process.

[0022] A cooling roller 2 is installed between the cooling extrusion roller 1 and the transmission system 3. The cooling roller 2 has internal cooling water channels for introducing cooling water to cool and convey the hot-melt material. A cooling coil 8 is installed below the transmission system 3, also with internal cooling water channels for introducing cooling water to cool the hot-melt material on the transmission system 3. A cold air system 4 is installed above the transmission system 3, blowing cooling airflow onto the hot-melt material on the transmission system 3 to achieve cooling. In a specific embodiment, the transmission system 3 can be a conveyor belt, with the cooling coil 8 located below the conveyor belt and the cold air system 4 located above it.

[0023] Along the conveying path of the hot-melt material, a cooling roller 2, a cooling coil 8 below the transmission system 3, and a cooling air system 4 above are sequentially installed, forming a multi-dimensional, progressive cooling system from bottom contact cooling to top convection cooling. This significantly increases the cooling area and cooling efficiency, ensuring that the hot-melt material can be uniformly and fully cooled to below its brittle temperature from the inside out before entering the crushing system 6, thereby greatly improving the crushing effect and product quality.

[0024] A temperature probe 9 is installed on the discharge side of the transmission system 3 to detect the temperature of the hot melt material.

[0025] By setting temperature probe 9, the actual temperature of the hot-melt material before entering the crushing system 6 can be monitored in real time, achieving precise process control. This prevents the hot-melt material from sticking to the blades and clumping due to insufficient cooling, and also avoids energy waste or even changes in the properties of the hot-melt material caused by over-cooling, ensuring the continuity and stability of the production process.

[0026] A pre-crushing system 5 is provided between the transmission system 3 and the crushing system 6 for preliminary crushing of the hot melt material.

[0027] By setting up the pre-crushing system 5, the cooled and shaped hot-melted material can be initially crushed, breaking down large pieces of hot-melted material into smaller particles. This achieves a reasonable division of labor between coarse and fine crushing, improves overall crushing efficiency, reduces equipment wear, and results in more uniform particle size of the output material.

[0028] This device also adopts an intelligent control system and an autonomous touch screen for visual operation, which enables precise control of material temperature, avoiding the decomposition of active ingredients in heat-sensitive drugs due to excessive temperature, and features high processing efficiency and stable molding.

[0029] Specific working methods: S1. After the hot-melt material is melted, it is extruded into a controllable thin sheet by the extrusion cooling roller 1; S2. The extrusion cooling roller 1 and transmission system 3 cooling technology achieve the glass transition of hot-melt materials; S3. Fine pulverization is carried out through the pre-pulverization system 5 and the pulverization system 6 to turn the hot melt material into controllable particles of 1-100μm; S4. Real-time control of the temperature of hot-melt materials is achieved through online temperature feedback technology composed of temperature probes 9.

[0030] Based on the above-described preferred embodiments of this utility model, and through the foregoing description, those skilled in the art can make various changes and modifications without departing from the technical concept of this utility model. The technical scope of this utility model is not limited to the contents of the specification, but must be determined according to the scope of the claims.

Claims

1. A hot-melt medicine pulverizing device for solid preparations, characterized by comprising: include: Cooling extrusion roller (1) has a cooling water channel inside for passing cooling water in and cooling and extruding hot melt material; The transmission system (3) is located on the discharge side of the cooling extrusion roller (1) and is used to receive and transport hot melt materials. The crushing system (6) is located on the discharge side of the transmission system (3) and is used to crush the hot melt material. The discharge port (7) is connected to the discharge end of the crushing system (6) and is used to discharge the crushed hot melt material.

2. The solid dosage form hot-melt pharmaceutical pulverizing device according to claim 1, characterized in that, A cooling roller (2) is provided between the cooling extrusion roller (1) and the transmission system (3), and a cooling water channel is provided inside the roller for introducing cooling water and cooling and conveying the hot melt material.

3. The solid dosage form hot-melt pharmaceutical pulverizing device according to claim 1, characterized in that, A cooling coil (8) is provided below the transmission system (3), and a cooling water channel is provided inside it for introducing cooling water and cooling the hot melt material on the transmission system (3).

4. The solid dosage form hot-melt pharmaceutical pulverizing device according to claim 1, characterized in that, A cooling system (4) is provided above the transmission system (3). The cooling system (4) is used to blow cooling airflow onto the hot melt material on the transmission system (3) to achieve cooling.

5. The solid dosage form hot-melt pharmaceutical pulverizing device according to claim 1, characterized in that, The transmission system (3) is equipped with a temperature probe (9) on the discharge side to detect the temperature of the hot melt material.

6. The solid dosage form hot-melt pharmaceutical pulverizing device according to claim 1, characterized in that, A pre-crushing system (5) is provided between the transmission system (3) and the crushing system (6) for preliminary crushing of the hot melt material.

7. The solid dosage form hot-melt pharmaceutical pulverizing device according to claim 1, characterized in that, The number of cooling extrusion rollers (1) is two, and the two cooling extrusion rollers (1) are arranged opposite to each other to form an extrusion channel for extruding the hot melt material.

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