NEW PHARMACEUTICAL COMPOSITION FOR DRUG DISTRIBUTION

Abstract

According to the invention, there is provided a pharmaceutically acceptable composition which is preferably in the form of a spray-dried powder comprising a mixture of: (a) a pharmacologically acceptable dosage amount of at least one pharmaceutically acceptable compound; and (b) a pharmaceutically acceptable carrier material, which carrier material comprises a combination of a disaccharide and a polymeric material. The compositions are suitable for, for example, transmucosal drug delivery, including sublingual and nasal delivery. In the case of nasal delivery, the aforementioned compositions may be loaded into single-use or multiple-use nasal application devices. Preferred pharmaceutically acceptable carriers in this context include lactose or trehalose and dextrins (e.g. cyclodextrins or maltodextrins), which may be spray-dried together in combination.The compositions may further comprise one or more alkyl saccharides. Preferred alkyl saccharides include sucrose esters, such as sucrose monolaurate.