Oral composition

Abstract

To provide an oral composition that contains a water-soluble copper salt and has a reduced metallic taste.SOLUTION: An oral composition contains a water-soluble copper salt, as well as Angelica acutiloba extract, Paeonia lactiflora extract, Salvia officinalis extract, and / or Panax ginseng extract, so that a metallic taste derived from the water-soluble copper salt is reduced, and a good feeling of use is achieved.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to an oral composition which contains a water-soluble copper salt and which has a reduced metallic taste. [Background technology]

[0002] Water-soluble copper salts such as copper gluconate are known to have a deodorizing effect and are widely used in oral compositions such as dentifrices and mouthwashes to prevent bad breath. On the other hand, oral compositions containing water-soluble copper salts have the disadvantage of leaving a metallic taste after use.

[0003] Therefore, various formulation techniques for suppressing the metallic taste in oral compositions containing water-soluble copper salts have been studied. For example, Patent Document 1 describes that an oral composition containing a water-soluble copper salt, benzyl alcohol, and xylitol and / or erythritol in a specific ratio can suppress the metallic taste. Patent Document 1 also describes that an oral composition containing a water-soluble copper salt and a propylene glycol alginate in a specific ratio has excellent durability of the effect of suppressing bad breath and can suppress the metallic taste.

[0004] The required functional properties of oral compositions are increasing year by year, and it is also necessary to respond to the diversification of formulations of oral compositions. Therefore, there is a demand for the development of new formulations that can suppress the metallic taste of oral compositions containing water-soluble copper salts. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] International Publication No. 2016 / 93279 [Patent Document 2] JP 2016-141661 A Summary of the Invention [Problem to be solved by the invention]

[0006] An object of the present invention is to provide an oral composition which contains a water-soluble copper salt and which has a reduced metallic taste. [Means for solving the problem]

[0007] The present inventors have conducted extensive research to solve the above problems and have found that by incorporating a water-soluble copper compound in an oral composition with an Angelica acutiloba extract, a peony root extract, a sage extract, and / or a carrot extract, the metallic taste caused by water-soluble copper salts can be suppressed and an excellent feeling of use can be imparted. The present invention was completed through further research based on this finding.

[0008] That is, the present invention provides the following aspects. Item 1. A composition for oral use comprising (A) a water-soluble copper salt and (B) at least one plant extract selected from the group consisting of Angelica acutiloba extract, peony root extract, sage extract, and carrot extract. Item 2. The oral composition according to Item 1, wherein the component (A) is copper gluconate. Item 3. A method for suppressing a metallic taste caused by a water-soluble copper salt in an oral composition containing the water-soluble copper salt, comprising: A method for suppressing a metallic taste, comprising blending an oral composition with (A) a water-soluble copper salt and (B) at least one plant extract selected from the group consisting of Angelica acutiloba extract, peony extract, sage extract, and carrot extract. Effect of the Invention

[0009] According to the present invention, in an oral composition containing a water-soluble copper salt, the metallic taste caused by the water-soluble copper salt is suppressed, and therefore an excellent feeling when used can be imparted. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0010] 1. Oral composition The oral composition of the present invention is characterized by containing (A) a water-soluble copper salt and (B) at least one plant extract selected from the group consisting of Angelica acutiloba extract, Peony root extract, Sage extract, and Carrot extract. The oral composition of the present invention will be described in detail below.

[0011] [Water-soluble copper salt] The oral composition of the present invention contains a water-soluble copper salt (sometimes referred to as component (A)). The water-soluble copper salt is a water-soluble organic acid salt or inorganic salt of copper.

[0012] The type of water-soluble copper salt used in the present invention is not particularly limited, so long as it is applicable to the oral cavity, and examples include copper gluconate, copper sulfate, copper chloride, copper citrate, copper nitrate, copper acetate, copper lactate, copper butyrate, copper formate, copper phosphate, copper malate, copper succinate, copper malonate, copper maleate, and the like.

[0013] These water-soluble copper salts may be used alone or in combination of two or more. Among these water-soluble copper salts, copper gluconate is preferred.

[0014] The content of component (A) in the oral composition of the present invention may be appropriately set depending on the form of the oral composition, the type of water-soluble copper salt used, the level of deodorizing effect to be imparted, etc., and may be, for example, 0.0001 to 5 wt %, preferably 0.0001 to 1 wt %, and more preferably 0.001 to 0.1 wt % in terms of the total amount of the water-soluble copper compound.

[0015] [Angelica extract, peony extract, sage extract, and / or carrot extract] The oral composition of the present invention contains at least one plant extract (sometimes referred to as component (B)) selected from the group consisting of Angelica acutiloba extract, Peony root extract, Sage extract, and Carrot extract, in addition to the water-soluble copper salt. In the oral composition of the present invention, these plant extracts play a role in suppressing the metallic taste caused by the water-soluble copper salt.

[0016] The scientific name of Angelica is Angela acutiloba, a perennial plant belonging to the Angelica genus of the Apiaceae family. Angelica extract can be obtained by extracting the roots of Angelica or its related plants (Umbelliferae) after removing the n-hexane and / or n-butanol soluble parts as necessary. That is, in the present invention, Angelica extract includes not only the extract of Angelica but also the extract of the related plants of Angelica.

[0017] Peony, scientific name Paeonia lactiflora, is a perennial plant of the genus Paeonia, family Paeoniaceae. Peony extract can be obtained by extracting the roots of peony or its related plants (Paeoniaceae). That is, in the present invention, peony extract includes not only extract of peony but also extract of related plants of peony.

[0018] Sage, whose scientific name is Salvia officinalis, is a perennial or evergreen shrub belonging to the Salvia genus of the Lamiaceae family. The sage extract used in the present invention can be obtained by subjecting the whole plant or leaves (preferably the leaves) of sage to an extraction treatment.

[0019] Carrot, scientific name Panax ginseng, also known as Panax ginseng (Japanese name), is a perennial plant belonging to the genus Panax in the family Araliaceae. Carrot extract can be obtained by extracting the whole plant or roots (preferably the roots) of carrot.

[0020] The extraction process for obtaining the plant extract may be a general extraction method used in the production of ordinary plant extracts. The plant raw material for the plant extract may be in a raw state as is, or may be subjected to pretreatment such as crushing, cutting, steaming, rolling, drying, roasting, etc., as necessary.

[0021] The extraction treatment can be carried out by solvent extraction treatment, supercritical extraction treatment, steam distillation treatment, etc. Among these, the solvent extraction treatment is preferable.

[0022] The extraction solvent used in the solvent extraction treatment may be appropriately selected according to the type of plant, and may include, for example, water; lower alcohols having 1 to 4 carbon atoms, such as methanol, ethanol, n-propanol, isopropanol, and n-butanol; polyhydric alcohols, such as propylene glycol and 1,3-butylene glycol; and mixtures thereof. More specifically, in the case of Angelica acutiloba extract, Peony root extract, and Carrot extract, the extraction solvent is preferably water, polyhydric alcohol, and mixtures thereof; more preferably water, 1,3-butylene glycol, and mixtures thereof; and even more preferably a mixture of water and 1,3-butylene glycol. In the case of sage extract, the extraction solvent is preferably water, lower alcohol, and mixtures thereof; more preferably water, ethanol, and mixtures thereof; and even more preferably a mixture of water and ethanol.

[0023] When a mixed solvent of water and a lower alcohol is used as the extraction solvent, the content of the lower alcohol in the mixed solvent is, for example, 10 to 99% by volume, preferably 20 to 99% by volume, more preferably 30 to 95% by volume, and even more preferably 40 to 95% by volume. When a mixed solvent of water and a polyhydric alcohol is used as the extraction solvent, the content of the polyhydric alcohol in the mixed solvent is, for example, 10 to 90% by volume, preferably 20 to 80% by volume, more preferably 30 to 70% by volume, and even more preferably 40 to 60% by volume.

[0024] The solvent extraction process may be carried out by immersing or refluxing the plant raw material in the extraction solvent. After the extraction process, the solid matter is removed by solid-liquid separation to obtain a plant extract. The obtained extract may be used as an extract as it is, or, if necessary, may be used as a concentrated extract or a dried extract after removing a part or all of the solvent.

[0025] In the oral composition of the present invention, as component (B), one may be selected from among angelica extract, peony extract, sage extract, and carrot extract and used alone, or two or more of these may be used in combination.

[0026] The content of the component (B) in the oral composition of the present invention may be appropriately set depending on the form of the oral composition, the type of plant extract used, etc., and may be, for example, 0.0001 to 1 wt% in terms of dry weight of the component (B). From the viewpoint of more effectively suppressing the metallic taste caused by the water-soluble copper salt, the content of the component (B) in the oral composition of the present invention (in terms of dry weight) is preferably 0.001 to 0.5 wt%, more preferably 0.01 to 0.2 wt%. In the present invention, the dry weight of the component (B) refers to the value obtained by converting the components derived from the plant raw material in the plant extract into the dry weight (dry solid content), and when the plant extract contains a solvent, excipient, etc., it refers to the value corresponding to the weight excluding these.

[0027] In the oral composition of the present invention, the ratio of component (A) to component (B) is determined depending on the respective contents of these two components, but for example, the amount of component (B) per 1 part by weight of component (A) is 0.001 to 100 parts by weight, preferably 0.1 to 50 parts by weight, and more preferably 1 to 20 parts by weight, calculated as dry weight.

[0028] [Other ingredients] The oral cavity composition of the present invention may contain other medicinal ingredients as necessary, in addition to the above-mentioned ingredients. Such medicinal ingredients are not particularly limited, as long as they can be incorporated into medicines, oral care products, etc., and examples thereof include bactericidal ingredients, bronchodilators, antitussives, expectorants, anti-inflammatory agents, glucosyltransferase inhibitors, plaque inhibitors, hypersensitivity inhibitors, tartar prevention agents, antipyretics, analgesics, antihistamines, bactericides, gastric mucosa protective agents, caffeines, vitamins, Chinese herbal medicines, and herbal ingredients.

[0029] In addition, the oral cavity composition of the present invention may contain a base or additive to obtain a desired formulation. Such base or additive is not particularly limited as long as it can be incorporated into pharmaceuticals, oral care products, etc., and examples thereof include aqueous solvents (water, lower alcohols, etc.), oily components, polyhydric alcohols, surfactants, refreshing agents, preservatives, thickeners, fragrances, flavoring agents, colorants, deodorizing components (other than water-soluble copper salts), pigments, buffers, pH adjusters, etc.

[0030] [Shape / Form of formulation] The form of the oral composition of the present invention is not particularly limited and may be any of liquid, semi-solid (gel, ointment, paste), or solid, but is preferably liquid or semi-solid.

[0031] The formulation of the oral composition of the present invention is not limited as long as it can be applied to the oral cavity and remain there for a certain period of time, and examples thereof include oral care products such as liquid dentifrice, toothpaste, mouthwash, oral spray (including throat spray), mouthwash, mouth freshener, oral paste, gum massage cream, etc. Among these, preferred are liquid dentifrice, toothpaste, mouthwash, and mouthwash, and more preferred are liquid dentifrice and toothpaste.

[0032] 2. How to reduce metallic taste The method for suppressing a metallic taste of the present invention is a method for suppressing a metallic taste caused by a water-soluble copper salt in an oral composition containing a water-soluble copper salt, and is characterized in that the oral composition is formulated with (A) a water-soluble copper salt and (B) at least one plant extract selected from the group consisting of Angelica acutiloba extract, peony extract, sage extract, and carrot extract.

[0033] In the method for suppressing metallic taste of the present invention, the types and amounts of the components used, the shape and formulation of the oral composition, etc. are as shown in the section "1. Oral composition" above. EXAMPLES

[0034] The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these.

[0035] The plant extracts used in the following Test Examples and Formulation Examples are as follows: The content of each plant extract shown in the following Tables 1 to 3 is the content as a liquid extract. · Angelica acutiloba extract : The roots of Angelica acutiloba are extracted with an aqueous solution containing approximately 50% by volume of 1,3-butylene glycol, and the dry solids are in the form of a liquid extract (dry solids content approximately 3.8 w / v%). Peony extract : A liquid extract (dry solid content approximately 4 w / v%) obtained by extracting peony root with an aqueous solution containing approximately 50% by volume of 1,3-butylene glycol. Sage extract : A liquid extract (dry solid content approximately 1 w / v%) obtained by extracting sage leaves with an aqueous solution containing approximately 90% ethanol by volume. Carrot extract : A liquid extract (dry solid content approximately 1.3 w / v%) obtained by extracting ginseng root with an aqueous solution containing approximately 50% by volume of 1,3-butylene glycol.

[0036] Test Example 1 The oral compositions (liquid) shown in Table 1 were prepared. The obtained oral compositions were evaluated for metallic taste by 10 trained subjects. Specifically, one drop of each oral composition was placed in the mouth with a dropper, and the metallic taste was evaluated by a questionnaire using a VAS (visual analogue scale). In the questionnaire, the left end of a 10 cm line was marked as "very strong metallic taste" and the right end was marked as "no metallic taste", and the subjects were asked to mark which position on the line corresponded to the sensation felt when each oral composition was placed in the mouth. The distance from the left end 0 cm of the marked position was taken as the VAS measurement value. The average of the obtained VAS measurement values ​​was taken as the evaluation result of the metallic taste.

[0037] The results are shown in Tables 1 and 2. In the oral composition containing copper gluconate alone, a strong metallic taste was felt (Comparative Example 1), and furthermore, even when the composition contained glycerin or sorbitol, which is a sweetener or masking agent, the metallic taste caused by copper gluconate could not be suppressed (Comparative Examples 2 and 3). In contrast, in the oral compositions containing copper gluconate together with Angelica acutiloba extract, Peony root extract, Sage extract, or Carrot extract, the metallic taste was suppressed, and an excellent feeling of use was observed (Examples 1 to 8).

[0038] [Table 1]

[0039] Prescription Examples A toothpaste having the composition shown in Table 2 and a liquid toothpaste having the composition shown in Table 3 were prepared. Both of these toothpastes and liquid toothpastes had a reduced metallic taste caused by water-soluble copper salts.

[0040] [Table 2]

[0041] [Table 3]

Claims

1. An oral composition comprising (A) a water-soluble copper salt and (B) a carrot extract.

2. The oral composition according to claim 1 , wherein the component (A) is copper gluconate.

3. A method for suppressing a metallic taste caused by a water-soluble copper salt in an oral composition containing the water-soluble copper salt, comprising: A method for suppressing metallic taste, comprising blending (A) a water-soluble copper salt and (B) a carrot extract into an oral composition.

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